Relevant bibliographies by topics / Histology, Pathological – Technique

Academic literature on the topic 'Histology, Pathological – Technique'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Histology, Pathological – Technique"

1

Zulli, Anthony, and James J. Liu. "A Novel Immunohistochemical Semiquantitative Technique for Endothelial Constitutive Nitric Oxide Synthase Immunoreactivity in Rat Coronary Artery." Journal of Histochemistry & Cytochemistry 46, no. 2 (February 1998): 257–62. http://dx.doi.org/10.1177/002215549804600215.

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It has been difficult to quantify protein production in small pathological specimens by conventional techniques. We describe a new method for semiquantification of immunohistochemical staining, which involves application of the enzyme-labeled avidin (LAB) technique, coupled with an ultra-sensitive and fast chemiluminescent substrate for alkaline phosphatase. The entire procedure can be completed in less than 3 hr. The final step involves X-ray film exposure for 30 min, and the optical density of the subsequent images is examined with a microcomputer imaging device. The optical densities are translated into relative protein concentrations by a reference standard curve, obtained via an immunoblot. To establish a model for semiquantification of endothelial constitutive nitric oxide synthase (eNOS) protein, we compared the coronary arteries of WKY rats fed a normal chow diet to the coronary arteries of WKY rats fed a cholesterol diet. Using this technique, we have found a relative 130-fold decrease in eNOS in the cholesterol-fed group compared to the normal chow-fed group.
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Montironi, Rodolfo, Antonio Lopez Beltran, Roberta Mazzucchelli, Liang Cheng, and Marina Scarpelli. "Handling of Radical Prostatectomy Specimens: Total Embedding with Large-Format Histology." International Journal of Breast Cancer 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/932784.

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A problem when handling radical prostatectomy specimens (RPS) is that cancer is often not visible at gross examination, and the tumor extent is always underestimated by the naked eye. The challenge is increased further by the fact that prostate cancer is a notoriously multifocal and heterogeneous tumor. For the pathologist, the safest method to avoid undersampling of cancer is evidently that the entire prostate is submitted. Even though whole mounts of sections from RPS appear not to be superior to sections from standard blocks in detecting adverse pathological features, their use has the great advantage of displaying the architecture of the prostate and the identification and location of tumour nodules more clearly, with particular reference to the index tumour; further, it is easier to compare the pathological findings with those obtained from digital rectal examination (DRE), transrectal ultrasound (TRUS), and prostate biopsies. We are in favour of complete sampling of the RPS examined with the whole mount technique. There are reasons in favour and a few drawbacks. Its implementation does not require an additional amount of work from the technicians’ side. It gives further clinical significance to our work of uropathologists.
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Crocetti, Laura, Paola Scalise, Elena Bozzi, Daniela Campani, Piercarlo Rossi, Rosa Cervelli, Irene Bargellini, Davide Ghinolfi, Paolo De Simone, and Roberto Cioni. "Microwave Ablation of Very-Early- and Early-Stage HCC: Efficacy Evaluation by Correlation with Histology after Liver Transplantation." Cancers 13, no. 14 (July 8, 2021): 3420. http://dx.doi.org/10.3390/cancers13143420.

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Microwave (MW) ablation is a worldwide-diffused technique for the percutaneous ablation of hepatocellular carcinoma (HCC). Nevertheless, the efficacy of this technique still needs to be confirmed in pathological specimens. The purpose of this study was to evaluate the efficacy of MW ablation by correlation with histology in excised liver samples at the time of liver transplantation (LT). All patients with MW-ablated HCC who subsequently underwent LT between 2012 and 2020 were retrospectively evaluated. In the explanted livers, the treated lesions were evaluated at pathology, and the necrosis was classified as complete or partial. Thirty-six HCCs were ablated in 30 patients (20.9 ± 6.1 mm, a range of 10–30 mm). Ablations were performed with a single insertion of a MW antenna under ultrasound or CT guidance. A complete radiological response was demonstrated in 30/36 nodules (83.3%) in 24/30 patients (80%) at imaging performed one-month after MW ablation. At pathology, of the 36 treated nodules, 28 (77.8%) showed a complete necrosis, and 8 (22.2%) showed a pathological partial necrosis. Good agreement was found between the imaging performed one-month after treatment and the complete pathological response (Cohen’s k = 0.65). The imaging accuracy in detecting a complete response to treatment was 88.9%. All lesions with complete necrosis did not show recurrence at follow-up imaging until transplantation. The rad-path correlation in the explanted livers showed that MW ablation achieved a high rate of complete necrosis if a macroscopical complete ablation was obtained.
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Jonsson, R., A. L. Karlsson, and R. Holmdahl. "Demonstration of immunoreactive sites on cartilage after in vivo administration of biotinylated anti-type II collagen antibodies." Journal of Histochemistry & Cytochemistry 37, no. 2 (February 1989): 265–68. http://dx.doi.org/10.1177/37.2.2911008.

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Administration of biotinylated monoclonal antibodies provides the basis of a simple technique for identifying immunoreactive sites in vivo. Biotinylated anti-type II collagen antibodies were injected intraperitoneally into normal DBA/1 mice. The mice were sacrificed after 96 hr and the front paws removed and decalcified to allow tissue sectioning before snap-freezing. Binding of antibodies in vivo was visualized with affinity cytochemical staining using avidin-biotin-peroxidase complexes. Specific binding of antibodies to cartilaginous structures was seen after injection of 20-500 micrograms biotinylated monoclonal or polyclonal anti-type II collagen antibodies, but not after injection of a biotinylated control antibody. This technique should further the detection and localization studies of tissue components involved in the dynamics of physiological and pathological processes.
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Tuson, J. R., E. W. Pascoe, and D. A. Jacob. "A novel immunohistochemical technique for demonstration of specific binding of human monoclonal antibodies to human cryostat tissue sections." Journal of Histochemistry & Cytochemistry 38, no. 7 (July 1990): 923–26. http://dx.doi.org/10.1177/38.7.2355173.

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We describe a novel immunohistochemical technique which permits the detection of specific binding of human monoclonal antibodies (MAb) to cryostat sections of human tissues. The technique overcomes the problem of background staining caused by the presence of endogenous immunoglobulins in tissue sections. This is achieved by the formation of a molecular complex of the primary antibody (a human MAb), horseradish peroxidase-conjugated goat anti-human immunoglobulin, and normal human serum. This complex is then incubated with cryostat sections of human tissue, and binding of the complex is demonstrated using diaminobenzidine/hydrogen peroxide. The method is suitable for immunohistochemical screening of small samples of tissue culture supernatant for the presence of human MAb of potential interest, and for determining the pattern of binding of such MAb to a wide range of normal and pathological human tissues.
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Cauda, Franco, Andrea Nani, Donato Liloia, Gabriele Gelmini, Lorenzo Mancuso, Jordi Manuello, Melissa Panero, Sergio Duca, Yu-Feng Zang, and Tommaso Costa. "Interhemispheric co-alteration of brain homotopic regions." Brain Structure and Function 226, no. 7 (June 25, 2021): 2181–204. http://dx.doi.org/10.1007/s00429-021-02318-4.

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AbstractAsymmetries in gray matter alterations raise important issues regarding the pathological co-alteration between hemispheres. Since homotopic areas are the most functionally connected sites between hemispheres and gray matter co-alterations depend on connectivity patterns, it is likely that this relationship might be mirrored in homologous interhemispheric co-altered areas. To explore this issue, we analyzed data of patients with Alzheimer’s disease, schizophrenia, bipolar disorder and depressive disorder from the BrainMap voxel-based morphometry database. We calculated a map showing the pathological homotopic anatomical co-alteration between homologous brain areas. This map was compared with the meta-analytic homotopic connectivity map obtained from the BrainMap functional database, so as to have a meta-analytic connectivity modeling map between homologous areas. We applied an empirical Bayesian technique so as to determine a directional pathological co-alteration on the basis of the possible tendencies in the conditional probability of being co-altered of homologous brain areas. Our analysis provides evidence that: the hemispheric homologous areas appear to be anatomically co-altered; this pathological co-alteration is similar to the pattern of connectivity exhibited by the couples of homologues; the probability to find alterations in the areas of the left hemisphere seems to be greater when their right homologues are also altered than vice versa, an intriguing asymmetry that deserves to be further investigated and explained.
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Péley, G., J. Tóth, O. Csuka, I. Sinkovics, E. Farkas, and I. Köves. "Immunohistochemistry and Reverse Transcriptase Polymerase Chain Reaction on Sentinel Lymph Nodes can Improve the Accuracy of Nodal Staging in Breast Cancer Patients." International Journal of Biological Markers 16, no. 4 (January 2001): 227–32. http://dx.doi.org/10.1177/172460080101600401.

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In this study the nodal staging sensitivity of sentinel lymph node biopsy (SLNB) with detailed pathological and molecular biological examination has been investigated and compared to that of axillary lymph node dissection (ALND) with routine histological evaluation. Sentinel lymph nodes (SLNs) were removed by the dual-agent injection technique in 68 patients with primary, clinically node-negative breast cancer. Forty-seven patients had negative SLNs according to hematoxylin and eosin (H&E) staining. These H&E-negative SLNs were serially sectioned and examined at 250 μm levels by anticytokeratin immunohistochemistry (IHC). In 14 patients the SLNs were also investigated by cytokeratin 20 (CK20) reverse transcriptase polymerase chain reaction (RT-PCR). SLNB with IHC increased the node-positive rate by 26% (by 40% in tumors less than or equal to 2 cm in size (pT1) and by 9% in tumors more than 2 cm but less than or equal to 5 cm in size (pT2)). The sensitivity of SLNB with IHC was superior to that of ALND with routine histology in pT1 tumors and identical in pT2 tumors. The concordance between histology and RT-PCR was only 21%, and in two of three cases with positive histological results RT-PCR was negative. In conclusion, SLNB with detailed pathological and/or molecular biological evaluation can improve the sensitivity of regional staging. ALND can probably be abandoned in patients with pT1 SLN-negative breast cancer. Further prospective studies are required to determine the clinical significance of these detailed SLN evaluation techniques, but at present these methods are still investigational.
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Chilosi, M., A. Mombello, L. Montagna, A. Benedetti, M. Lestani, G. Semenzato, and F. Menestrina. "Multimarker immunohistochemical staining of calgranulins, chloroacetate esterase, and S100 for simultaneous demonstration of inflammatory cells on paraffin sections." Journal of Histochemistry & Cytochemistry 38, no. 11 (November 1990): 1669–75. http://dx.doi.org/10.1177/38.11.2212622.

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Mac387 monoclonal antibody (MAb) recognizes two calcium binding, myeloid-associated proteins, now termed calgranulins, expressed at high levels by neutrophils and monocytes. Calgranulins are related to migration inhibitory factor (MIF) and are lost in a few days from monocytes differentiated in vitro. This marker is therefore potentially useful to analyze macrophage heterogeneity and turnover in tissue sections. In this study, we developed an immunohistochemical multimarker technique, including calgranulin demonstration, suitable for analyzing different inflammatory cells on paraffin-embedded material. The technique was carried out in subsequent steps demonstrating (a) naphthol AS-D chloroacetate esterase (CAE); (b) S100 immunoreactivity using a rabbit antibody in peroxidase-antiperoxidase (PAP) staining; and (c) Mac387 immunoreactivity using the alkaline phosphatase-anti-alkaline phosphatase (APAAP) technique. CAE staining was introduced in this method to distinguish Mac387+/CAE- macrophages from Mac387+/CAE+ neutrophils, and Mac387-/CAE+ mast cells. S100 protein is strongly expressed within lymphoid tissues by dendritic accessory cells and was then applied to distinguish these cells from S100-macrophages. We have also verified the possibility of reducing the staining time for this time-consuming procedure by use of microwave irradiation. The technique was applied to a representative variety of normal and pathological samples to assess its usefulness for study of cell heterogeneity. Our results showed the multimarker technique to be highly informative in the study of inflammatory lesions (e.g., rheumatoid arthritis, sarcoid and cat-scratch granulomas, dermathopathic lymphadenopathy), and is of wide potential value as an aid to histopathological diagnosis of several diseases.
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9

Dinneen, Eoin, Aiman Haider, and Greg Shaw. "NeuroSAFE technique—pathological considerations and practical implications for guiding nerve‐sparing surgery in prostate cancer patients." Histopathology 77, no. 4 (September 17, 2020): 536–38. http://dx.doi.org/10.1111/his.14183.

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10

Benini, E., R. Silvestrini, M. G. Daidone, and S. Canova. "Detection of P53 expression and S-phase cell fraction in paraffin-embedded tissue by a double-labeling technique." Journal of Histochemistry & Cytochemistry 43, no. 10 (October 1995): 999–1003. http://dx.doi.org/10.1177/43.10.7560890.

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TP53 is a gene that normally regulates cell growth and division. Alterations to it may induce a proliferative advantage and confer an aggressive phenotype. In breast cancer, we observed a poor correlation (rs = 0.17) between P53 expression and proliferative activity evaluated as [3H]-thymidine ([3H]-dT) labeling index and an independent prognostic relevance of the two variables. We used a double-labeling technique to simultaneously evaluate the fraction of P53-positive and [3H]-dT-labeled cells to analyze the degree of association between the two markers on individual cells in order to understand their biological significance. The study was performed on a series of 44 P53-positive (P53+) breast cancers. Histological sections were immunostained for P53 with monoclonal antibody (MAb) PAb1801 and then processed for autoradiography. A weak direct relation between P53 positivity and [3H]-dT incorporation (rs = 0.4) was observed on the overall series of P53+ tumors and was maintained in subgroups defined by several biological and pathological features, except for estrogen receptor-negative tumors. The simultaneous presence of P53 expression and [3H]-dT incorporation was directly and significantly proportional to the fraction of S-phase cells of the tumor (rs = 0.7). Conversely, the fraction of cells expressing only P53 was inversely related to cell proliferation (rs = -0.66). These findings support the hypothesis that P53 has biological functions other than cell cycle regulation.
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Books on the topic "Histology, Pathological – Technique"

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Carson, Freida L. Histotechnology: A self instructional text. Chicago: ASCP Press, 1990.

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Carson, Freida L. Histotechnology: A self-instructional text. 2nd ed. Chicago: ASCP Press, 1997.

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3

Jumer, Patricia A. Microwave modified procedures for the histotechnician in an hour or less. Anchorville, Mich: I.S.A.C. Technologies, 1994.

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Sheehan, Dezna C. Theory and practice of histotechnology. 2nd ed. Columbus, Ohio: Battelle Press, 1987.

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5

Luna, Lee G. Histopathologic methods and color atlas of special stains and tissue artifacts. Gaitheresburg, MD: American Histolabs, 1992.

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6

W, Hamilton Peter, and Allen Derek C, eds. Quantitative clinical pathology. Oxford [England]: Blackwell Science, 1995.

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7

Jasani, Bharat. Immunocytochemistry in diagnostic histopathology. Edinburgh: Churchill Livingstone, 1993.

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W, Schmid Kurt, ed. Immunocytochemistry in diagnostic histopathology. Edinburgh: Churchill Livingstone, 1993.

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9

Lowe, D. G. Macro techniques in diagnostic histopathology. London: Wolfe Medical Publications, 1990.

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10

C, Cook H., ed. Manual of histological techniques and their diagnostic applications. Edinburgh: Churchill Livingstone, 1994.

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Book chapters on the topic "Histology, Pathological – Technique"

1

Fitzpatrick, John, Asif Muneer, Jean de la Rosette, and Thomas Powles. "Genitourinary cancers." In Oxford Textbook of Oncology, 602–27. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0045.

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Genitourinary cancers include tumors of the penis, bladder, prostate, testes, kidneys and ureters. Penile cancer is a rare malignancy and the diagnosis is often delayed due to patient embarrassment. Penile-preserving surgical techniques have been developed to preserve penile length. Urothelial cell carcinoma is more often encountered in bladder (95%) than in the upper urinary tract (5%). This chapter will be divided according to the two main urothelial cell carcinoma topographies: bladder and upper urinary tract. Prostate cancer is second as far as cause of cancer death is concerned, and surgical, radiotherapeutic and hormonal treatments are discussed. Most testicular cancers that arise are germ cell tumours. Renal cell carcinoma has a number of distinct pathological types. The commonest is clear cell histology which is intrinsically linked to Von Hippel-Lindau (VHL) mutations. New targeted therapies for renal carcinomas will be described in detail.
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Bhindi, Ravinay, and Keith M. Channon. "Virtual histology intravascular ultrasound and optical coherence tomography in percutaneous coronary intervention." In Oxford Textbook of Interventional Cardiology, 174–82. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199569083.003.011.

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The inadequacies of angiography to identify and characterize coronary atherosclerosis were not fully appreciated until pathologic studies revealed that coronary atherosclerosis in patients with fatal myocardial infarction was typically diffuse and in many cases was accompanied by positive remodelling, without luminal stenosis. Pathologic studies also identified the critical pathophysiogical role of plaque rupture in coronary thrombosis, and the appreciation that plaque biology and composition, rather than luminal stenosis alone, were more critical determinants of plaque behaviour. Clinical and experimental studies have shown that the vulnerable plaque, prone to rupture, is characterized by a large lipid core rich in inflammatory cells, a thin fibrous cap, and by positive remodelling. The development of novel intracoronary imaging techniques has enabled a greater appreciation of plaque composition in the pathogenesis of coronary artery disease in living patients. In particular, advances in intravascular ultrasound (IVUS) to provide ‘virtual histology’ of coronary plaque components, and optical coherence tomography (OCT) to define plaque composition in exquisite detail have provided new insights into the relationships between coronary plaque, the risk of clinical events, and the response of the vessel wall to percutaneous intervention.
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