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Journal articles on the topic 'Histologie quantitative'

Author: Grafiati

Published: 25 May 2024

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1

Boly, H., MT Hochereau-de Reviers, P. Humblot, and M. Thibier. "Effets pathogènes de Trypanosoma congolense sur le testicule des taurins Baoulé : histologie quantitative et morphométrique." Reproduction Nutrition Development 33, no. 6 (1993): 541–50. http://dx.doi.org/10.1051/rnd:19930605.

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Marek, W., S. Krampe, N. J. Dickgreber, L. Nielsen, A. Muti, B. Khanavkar, K. M. Müller, Z. Atay, Th Topalidis, and J. A. Nakhosteen. "Automatisierte quantitative Image-Zytometrie bronchialer Spülflüssigkeiten bei Verdacht auf broncho-pulmonale Tumoren: Vergleich mit Zytologie, Histologie und klinischer Diagnose." Pneumologie 53, no. 12 (December 1999): 583–95. http://dx.doi.org/10.1055/s-1999-9047.

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Neuerburg, J., U. Fabry, U. Cremerius, G. Wagenknecht, D. Hellwig, R. Osieka, R. Günther, U. Büll, and R. Thill. "Vergleich der Befunde von 18-FDG- PET und CT beim prätherapeutischen Staging maligner Lymphome." Nuklearmedizin 36, no. 07 (1997): 234–39. http://dx.doi.org/10.1055/s-0038-1629839.

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Zusammenfassung Ziel: Vergleich der diagnostischen Aussagekraft von FDG-PET und CT zum Staging vor Therapie unter Berücksichtigung von Lokalisation, Durchmesser und Histologie der Läsion sowie Erfassung des FDG-Uptakes. Methoden: CT- und FDG-PET-Untersuchungen bei 27 Patienten mit histologisch gesichertem malignen Lymphom als Erstmanifestation oder Rezidiv wurden retrospektiv und unabhängig voneinander ausgewertet. CT-positive nodale Läsionen waren im Querdurchmesser (DCT) >15 mm. Bei visueller Auswertung in iterativ rekonstruierten PET-Studien gefundene fokale, unphysiologische FDG-Speicherungen wurden positiv gewertet und hinsichtlich Läsionsgröße (DPET) und partial-volumenkorrigierten standardisierten Uptake-Werten (SUV) quantifiziert. Eine Unterteilung der Läsionen erfolgte nach Histologie und Qualität (abgrenzbarer Lymphknoten, Konglomerattumor, extranodale Läsion). Ergebnis: CT beschrieb bei 26 Patienten 78 Läsionen, alle auch durch PET bestätigt. PET lokalisierte darüber hinaus weitere 18 Läsionen (+23%), bei hochmalignen Non-Hodgkin-Lymphomen (NHL) sogar +25%. Im Bereich des Halses sowie bei Lungenläsionen waren die Verfahren gleichwertig, bei der Beurteilung der übrigen Lymphknotenregionen sowie von Leber und Milz wies PET mehr Läsionen nach. Der SUV war bei hochmalignen NHL (19,0) signifikant höher als bei niedrigmalignen NHL und M. Hodgkin (10,6 bzw. 11,1). DCT und DPET korrelierten bei abgrenzbaren Lymphknoten signifikant (r = 0,75). Schlußfolgerung: FDG-PET ist der CT im Staging maligner Lymphome vor Therapie ebenbürtig bis überlegen. Hierzu ist eine qualitative Befundung ausreichend. Die zusätzliche quantitative Auswertung kann bei NHL einen Hinweis auf den Malignitätsgrad geben.

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Schröder, W., S. Wolters, U. Cremerius, W. Rath, U. Büll, and M. Zimny. "18F-Fluordeoxyglukose PET beim Ovarialkarzinom: Methodik und erste Ergebnisse." Nuklearmedizin 36, no. 07 (1997): 228–33. http://dx.doi.org/10.1055/s-0038-1629838.

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Zusammenfassung Ziel der vorliegenden Studie war die Evaluierung der PET mit 18F-Fluor-deoxyglukose in der Primär- und Rezidivdiagnostik von Ovarialkarzino-men. Methoden: Untersucht wurden 26 Patientinnen mit Verdacht auf primäres Ovarialkarzinom (n = 17) bzw. Rezidiwerdacht (n = 9). Die PET-Untersuchung von Abdomen und Becken erfolgte mit einem ECAT 953/15-Scanner beginnend 45 min nach i.v. Applikation von im Mittel 245 MBq 18FDG. Die PET-Ergebnisse wurden anhand von intraoperativem Befund, Histologie und Zytologie validiert. Ergebnisse: Der richtige Nachweis eines primären, malignen Ovarialtumors bzw. eines Rezidivs gelang in 16 von 19 Fällen, der Malignomausschluß in sechs von sieben Fällen. Falsch negative PET-Befunde wurden bei zwei Borderline-Karzinomen und einem gut differenzierten, serös-muzinösen Ovarialkarzinom erhoben. Ein falsch positiver PET-Befund ergab sich bei einer abszedierenden Salpingoophoritis. Die quantitative Analyse erbrachte einen SUV von 6,8 ± 2,3 für primäre, epitheliale Ovarialkarzinome gegenüber 2,6 ± 1,2 bei benignen, nicht entzündlichen Raumforderungen (p <0,05). Schlußfolgerung: Diese vorläufigen Ergebnisse zeigen, daß PET mit 18FDG zwar geeignet ist zur Rezidivdiagnostik von Ovarialkarzinomen, jedoch limitiert ist in der Differenzierung von Borderline-Karzinomen gegenüber benignen Veränderungen sowie malignen Tumoren des Ovars gegenüber entzündlichen Prozessen. Die quantitative Bildanalyse führt hierbei nicht zu einer Verbesserung der diagnostischen Genauigkeit.

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Bozzato, Alessandro, Johannes Zenk, Holger Greess, Joachim Hornung, Frank Gottwald, Christina Rabe, and Heinrich Iro. "Potential of ultrasound diagnosis for parotid tumors: Analysis of qualitative and quantitative parameters." Otolaryngology–Head and Neck Surgery 137, no. 4 (October 2007): 642–46. http://dx.doi.org/10.1016/j.otohns.2007.05.062.

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Objective Histology of parotid tumors determines the extent of surgery. The aim was to test ultrasound (US) contrast enhancer-kinetics to identify histologic entities, possibly being superior to qualitative morphological parameters. Study Design In a cross-sectional assessment of ultrasound diagnosis, the subjective US-classification was compared with contrast analysis with histology as gold standard. Subjects and Methods A total of 64 male and 61 female patients with a mean age of 54 years were included, with 13 malignant tumors. These were classified with US morphology, then time-dependent contrast medium analysis. Results A total of 92.8% of tumors were classified correctly as malignant or benign. The sensitivity, specificity, positive- and negative-predictive values were 66.7%, 86.3%, 60.6%, and 89.1% for differentiating Warthin tumors, but only 46.2%, 98.2%, 75%, and 94% for malignant lesions. Contrast parameters yielded significant parameters for benign tumors, not for malignant entities. Conclusion Although contrast medium analysis provided statistical criteria, these, however, do not possess the ability to improve the diagnostic prediction of tumor histology. Neither the morphologic classification nor contrast medium analysis was able to identify a malignant lesion sufficiently.

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Khalil, Farah, Hernani Cualing, Julia Cogburn, and Lili Miles. "The Criteria for Bone Marrow Recovery Post–Myelosuppressive Therapy for Acute Myelogenous Leukemia: A Quantitative Study." Archives of Pathology & Laboratory Medicine 131, no. 8 (August 1, 2007): 1281–89. http://dx.doi.org/10.5858/2007-131-1281-tcfbmr.

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Abstract Context.—Although the early post–myelosuppressive chemotherapy pathologic changes of the marrow have been described, the rate and the histologic definition of recovery are not defined. Objective.—To study the rate of recovery of bone marrow in patients given myelosuppressive therapy for acute myelogenous leukemia, establish the histologic criteria of recovered marrow, and correlate the recovery pattern with those patients who received a bone marrow transplant by using histology, peripheral blood, immunophenotyping, and computerized morphometry and mathematical slope equation. Design.—We studied the post–myelosuppression recovery of the bone marrow to determine patterns and rate of recovery in 135 serial bone marrow biopsies of 51 patients. These patients were divided into 2 groups: 1 group of 28 cases diagnosed with acute myeloid leukemia, the majority treated with cytarabine (Ara-C) infusion for 7 days and daunorubicin intravenously daily for 3 days (7+3 regimen), and the other control group of 23 cases treated with chemotherapy or allogeneic bone marrow transplantation for a variety of hematologic malignancies. All biopsies during the recovery period were obtained before consolidation regimen. We used morphometry to calculate the cellularity and myeloid to erythroid ratio and quantified megakaryocytes CD10 versus time from day 14 onward. The absolute neutrophil and platelet counts for 28 cases were related to histologic recovery. Results.—From day 14, we noted a differential slope of recovery of these patients with no difference in male and female patients, P = .45, but a difference between younger and older patients (>58.5 years), P = .03. After regenerative hyperplasia, the cellularity plateaus, the myeloid to erythroid ratio, and the megakaryocytes even out with platelet normalization, and the early CD10+ B cells rise from day 40 onward, P = .01. The patterns of recovery after day 60 of postchemotherapy and posttransplantation patients are similar. Complete histologic and peripheral blood recovery is noted at day 38 and thereafter. Conclusions.—By linear equation using at least 2 trephine biopsy specimens, the projected rate of cellular recovery may be determined, and 5 histologic features are associated with complete histologic recovery.

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Fabregas, Neus, Antoni Torres, Mustafa El-Ebiary, Josep Ramirez, Carmen Hernandez, Julia Gonzalez, Jorge Puig de la Bellacasa, Jimenez de Anta, and Robert Rodriguez-Roisin. "Histopathologic and Microbiologic Aspects of Ventilator-associated Pneumonia." Anesthesiology 84, no. 4 (April 1, 1996): 760–71. http://dx.doi.org/10.1097/00000542-199604000-00002.

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Background The relationship between microbiology and histology in patients with ventilator-associated pneumonia has been sparsely described. Methods Twenty-five patients who died in the intensive care unit after their lungs had been mechanically ventilated for 72 h were studied. Twenty of the 25 died with clinical suspicion of pulmonary infection. A total of 375 immediate postmortem pulmonary biopsies were obtained after death and processed for quantitative microbiology and histology. Four evolutionary stages of pneumonia were defined: early, intermediate, advanced, and resolution. Results At least one specimen with histologic evidence of pneumonia was found in all but two patients (92%). Histologic pneumonia was a widespread and frequent process (46%) of biopsies examined) involving predominantly the lower lobes (55% of all biopsies with pneumonia) and showing different histopathologic stages of progression coexisting in the same lung lobes. Lung cultures were frequently polymicrobial (149 of 375, 40% of the pulmonary biopsy cultures, and 20 of 25, 80% of the cases) and not always yielding the same pathogen (19 microorganisms) when comparing one lung to the other. Histopathology and microbiologic biopsy cultures showed a weak relationship (28% and 49% of species had counts > or = 10(3) cfu/g in samples without pneumonia from patients with and without prior antibiotic treatment, respectively). Histopathologic evolutionary stages were not associated with any differences in quantitative culture results of pulmonary biopsies, independently of prior administration of antibiotics. Higher bacterial concentrations of biopsy cultures were associated with the absence of prior antibiotic treatment. Conclusions Ventilator-associated pneumonia is a frequent diffuse and polymicrobial process showing different coexisting degrees of evolution and involving preferentially the lower lobes. Microbiology and histology can be dissociated even in the absence of prior antibiotic treatment. Lung histology appears more reliable than bacteriology as a diagnostic reference test.

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Fitzgerald, Tamara N., Akihito Muto, Fabio Akimaro Kudo, Jose Mario Pimiento, Robert Todd Constable, and Alan Dardik. "Emerging Vascular Applications of Magnetic Resonance Imaging: A Picture is Worth More than a Thousand Words." Vascular 14, no. 6 (November 2006): 366–71. http://dx.doi.org/10.2310/6670.2006.00062.

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Vascular applications of magnetic resonance (MR) imaging are reviewed, with emphasis on algorithms that use nonpictorial information contained in the MR data set. Current clinical vascular practice generally limits use of MR angiography and three-dimensional vessel images to qualitative pictorial rendering without routinely using the available quantitative information contained within the MR data. This review is dedicated to recent advances that include characterization of vessel histology, assessment of carotid plaque vulnerability, characterization of blood flow dynamics, quantitative analysis of disease severity, and prediction of vascular intervention outcome. Examples from histologic preparation, in vitro and in vivo experiments, are discussed, with an emphasis on potential clinical applications and advances in acquisition technology.

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Hendricks, James B. "Quantitative Histology by Laser Scanning Cytometry." Journal of Histotechnology 24, no. 1 (March 2001): 59–62. http://dx.doi.org/10.1179/his.2001.24.1.59.

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Allan Johnson, G., Alexandra Badea, and Yi Jiang. "Quantitative Neuromorphometry Using Magnetic Resonance Histology." Toxicologic Pathology 39, no. 1 (November 30, 2010): 85–91. http://dx.doi.org/10.1177/0192623310389622.

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Paulus, Werner, and Juergen Peiffer. "Intratumoral histologic heterogeneity of gliomas. A quantitative study." Cancer 64, no. 2 (July 15, 1989): 442–47. http://dx.doi.org/10.1002/1097-0142(19890715)64:2<442::aid-cncr2820640217>3.0.co;2-s.

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Klencki, Mariusz, Dorota Słowińska-Klencka, and Andrzej Lewiński. "Multifarious System for Quantitative Analysis of Histologic Compartments." Computers and Biomedical Research 30, no. 2 (April 1997): 165–69. http://dx.doi.org/10.1006/cbmr.1997.1443.

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Sampedro, Andres, Cesar A. Alvarez, Carlos Suarez, and Angel M. Nistal. "Quantitative Pathology of the Intraepithelial Laryngeal Neoplasia." Otolaryngology–Head and Neck Surgery 110, no. 2 (February 1994): 185–94. http://dx.doi.org/10.1177/019459989411000208.

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A clinical-histologic and morphometric study on 32 patients with precancerous laryngeal lesions was carried out. Two biopsies taken at different times were studied, and the cases in which carcinoma developed were compared with those cases in which it did not. The only clinical-histologic variable with prognostic value, related with evolution to carcinoma, was severe dysplasia. The Malignancy Grading System, which grouped together 13 clinical-histologic variables, had both high sensitivity and high specificity. On the other hand, quantitative microscopy was a more sensitive and objective method. Through the relationship between the parameters of orientation/nuclearity and Histometric Progression Index, we could separate those cases in which invasive carcinoma developed from those cases in which it did not with a sensitivity of 100% and a specificity of 82%.

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Argani, Pedram, and Emma E. Furth. "Intrahepatic Iron Variation May Greatly Affect the Hepatic Iron Index." International Journal of Surgical Pathology 3, no. 4 (April 1996): 263–66. http://dx.doi.org/10.1177/106689699604030406.

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The quantitative hepatic iron index is considered the gold standard for the diagnosis of primary hemochromatosis. While intrahepatic variability in the amount of stainable iron in histologic sections of liver is well known, the quantitative variability has not been addressed. Eight native livers removed at transplantation for cirrhosis associated with hepatitis C were studied. Iron-stained sections from multiple different areas of each liver were examined, and small areas were graded for iron content on a scale of 0 to 4. The fragments of liver corresponding to these were then cut out of the corresponding section of the paraffin block and sent for iron quantitation. We found that marked quantitative heterogeneity in iron content (>260%) can exist in a given liver, leading, in two cases, to false positive results for the diagnosis of hemochromatosis. In addition, it was found that quantitative iron content did indeed linearly correlate with histologic grading. Thus, intrahepatic variation in iron content in a given liver is yet another reason to interpret the hepatic iron index with caution.

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Kirkwood, J. K., and N. F. Kember. "Comparative quantitative histology of mammalian growth plates." Journal of Zoology 231, no. 4 (December 1993): 543–62. http://dx.doi.org/10.1111/j.1469-7998.1993.tb01937.x.

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Gerstner, Andreas O. H., Christine Trumpfheller, Paul Racz, Pavel Osmancik, Klara Tenner-Racz, and Attila Tárnok. "Quantitative histology by multicolor slide-based cytometry." Cytometry Part A 59A, no. 2 (May 17, 2004): 210–19. http://dx.doi.org/10.1002/cyto.a.20054.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavare, and E. T. Hedley-Whyte. "Quantitative Histologic Factors for Grouping Childhood Supratentorial Neuroglial Tumors." Fetal and Pediatric Pathology 17, no. 5 (September 1, 1997): 729–54. http://dx.doi.org/10.3109/15513819709168598.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavare, E. T. Hedley-Whyte, L. Rorke, L. Adelman, and R. Sobel. "Quantitative Histologic Factors for Grouping Childhood Infratentorial Neuroglial Tumor." Fetal and Pediatric Pathology 17, no. 5 (September 1, 1997): 809–34. http://dx.doi.org/10.3109/15513819709168602.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavare, and E. T. Hedley-Whyte. "QUANTITATIVE HISTOLOGIC FACTORS FOR GROUPING CHILDHOOD SUPRATENTORIAL NEUROGLIAL TUMORS." Pediatric Pathology & Laboratory Medicine 17, no. 5 (September 1, 1997): 729–54. http://dx.doi.org/10.1080/107710497174453.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavare, E. T. Hedley-Whyte, L. Rorke, L. Adelman, and R. Sobel. "QUANTITATIVE HISTOLOGIC FACTORS FOR GROUPING CHILDHOOD INFRATENTORIAL NEUROGLIAL TUMORS." Pediatric Pathology & Laboratory Medicine 17, no. 5 (September 1, 1997): 809–34. http://dx.doi.org/10.1080/107710497174499.

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Gilles, F. H., MD Sobel, PhD Leviton, SM Tavare, Biostatistics, E. T. Hedley-Whyte, MD Rorke, MD Adelman, and MD Sobel. "QUANTITATIVE HISTOLOGIC FACTORS FOR GROUPING CHILDHOOD INFRATENTORIAL NEUROGLIAL TUMORS." Fetal and Pediatric Pathology 17, no. 5 (September 1, 1997): 809–34. http://dx.doi.org/10.1080/713601328.

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Gilles, F. H., MD Sobel, PhD Leviton, C. J. Tavare, and E. T. Hedley-Whyte. "QUANTITATIVE HISTOLOGIC FACTORS FOR GROUPING CHILDHOOD SUPRATENTORIAL NEUROGLIAL TUMORS." Fetal and Pediatric Pathology 17, no. 5 (September 1, 1997): 729–54. http://dx.doi.org/10.1080/713601333.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavaré, and E. T. Hedley-Whyte. "Quantitative Histologic Factors for Grouping Childhood Supratentorial Neuroglial Tumors." Pediatric Pathology & Laboratory Medicine 17, no. 5 (January 1997): 729–54. http://dx.doi.org/10.1080/15513819709168598.

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Gilles, F. H., E. L. Sobel, A. Leviton, C. J. Tavaré, E. T. Hedley-Whyte, L. Rorke, L. Adelman, and R. Sobel. "Quantitative Histologic Factors for Grouping Childhood Infratentorial Neuroglial Tumor." Pediatric Pathology & Laboratory Medicine 17, no. 5 (January 1997): 809–34. http://dx.doi.org/10.1080/15513819709168602.

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Origuchi, Yoshihiro, Isematsu Eda, Shin-ichi Matsumoto, and Akio Furuse. "Quantitative histologic study of sural nerves in xeroderma pigmentosum." Pediatric Neurology 3, no. 6 (November 1987): 356–59. http://dx.doi.org/10.1016/0887-8994(87)90007-5.

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Sucipto, Kathleen, Archit Khosla, Michael Drage, Yilan Wang, Darren Fahy, Mary Lin, Murray Resnick, et al. "QUANTITATIVE AND EXPLAINABLE ARTIFICIAL INTELLIGENCE (AI)-POWERED APPROACHES TO PREDICT ULCERATIVE COLITIS DISEASE ACTIVITY FROM HEMATOXYLIN AND EOSIN (H&E)-STAINED WHOLE SLIDE IMAGES (WSI)." Inflammatory Bowel Diseases 29, Supplement_1 (January 26, 2023): S22—S23. http://dx.doi.org/10.1093/ibd/izac247.042.

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Abstract BACKGROUND Microscopic inflammation has been shown to be an important indicator of disease activity in ulcerative colitis (UC). However, manual histologic scoring is semi-quantitative and subject to interobserver variation, and AI-based solutions often lack interpretability. Here we report two distinct quantitative approaches to predict disease activity scores and histological remission using AI-powered digital pathology. Both the random forest classifier (RFC) and graph neural network (GNN) further provide explainability and biological insight by identifying histological features informing model predictions. METHODS Convolutional neural networks (CNNs) were developed using >162k annotations on 820 WSI of H&E-stained colorectal biopsies for pixel-level identification of tissue regions (e.g. crypt abscesses, erosion/ulceration) and cell types (e.g. neutrophils, plasma cells). All WSI were scored by 5 board-certified pathologists using the Nancy Histological Index (NHI) to establish consensus ground truth. A rich, quantitative set of human interpretable features that capture CNN predictions of the tissue region and cell type across each WSI was extracted and used to train a RFC to predict slide-level NHI score. To test the hypothesis that tissue region spatial relationships and cellular composition can inform AI-based predictions of disease activity, a separate GNN was trained, using nodes defined by spatially-resolved CNN model-generated outputs, to predict NHI score. The RFC and GNN also predicted histologic remission (NHI<2). Feature importance was calculated for all combinations of RFC (Fig. 1), and the GNNExplainer was applied to locate important interactions between regions in the tissue and identify features significantly contributing to GNN predictions (Fig. 2). RESULTS The RFC and GNN both predicted histologic remission with high accuracy (weighted kappa 0.87 and 0.85, respectively). Both models also identified histologic features relevant to disease activity predictions. Some features are well established, e.g. infiltrated epithelium or neutrophil cell features distinguish cases with histologic remission. The models also identified features beyond those assessed by the NHI, e.g. area proportion of basal plasmacytosis associated with predictions of NHI 2 and 3. Other features not previously implicated in UC disease activity were also identified, e.g. intraepithelial lymphocytes differentiate cases with NHI 3. CONCLUSIONS We report quantitative and interpretable AI-powered approaches for UC histological assessment. CNN identification of UC histology was used as input to two distinct disease activity classifiers that showed strong concordance with consensus pathologist scoring. Both approaches provide interpretable features that explain model predictions and that may be used to inform biomarker selection and clinical development efforts.

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Troyer, Dean A., Jeffrey R. Shuster, and Raymond S. Lance. "Metabolomics and histology on exactly the same ex vivo prostate biopsy." Journal of Clinical Oncology 30, no. 5_suppl (February 10, 2012): 166. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.166.

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166 Background: Histopathology is the standard method for diagnosis and histological grading and staging of cancer. Molecular biomarkers are associated with cancer aggressiveness. One drawback to some molecular studies is that the portion of the tissue to be analyzed is processed in a manner that is destructive to the tissue. We present here a new method for performing analysis of small molecule biomarkers and histology in exactly the same biopsy tissue. The process, molecular Preservation by Extraction and Fixation (mPREF), allows traditional histological examination to be combined with qualitative and quantitative analysis of small molecule biomarkers. Methods: 18 gauge core biopsies were obtained ex vivo from prostatectomy specimens. One core biopsy/specimen container was immersed in aqueous alcohol. After 12-24 hrs, biopsies were transferred to UMFIX, and the original alcohol retained. Histologic sections of biopsies were stained by routine methods and the immunohistochemical (IHC) stain, PIN4. Small molecular weight molecules in the retained alcohol were examined by a mass spectrometry-based method. Results: Light Microscopy: Tumor and grade were evaluable and IHC for PIN4 performed well. Metabolomics of Retained Alcohol: From a single core biopsy, 260 named biochemical compounds and their relative concentrations WERE detected. 83 were different between the cancer and non-cancer biopsy extracts (p< .05). 18 of the 20 common amino acids, and a number of long chain fatty acids and phospholipids were increased. Highest fold changes, 4- to 6-fold, were observed in cysteine, dihomo-linoleate, docosapentaenoate, N-acetylaspartate, N-acetylglucosamine, uracil, xanthine, and 1-stearoylglycerophosphoinositol. A sub-set of candidate biomarkers were differentially expressed in pT3 vs pT2 disease. Conclusions: MPREF allows for both histology and detection of small molecules in exactly the same tissue. The results suggest a higher metabolic state in cancer as compared with non-cancer containing biopsy tissues. Differential expression of small molecules from pT2 vs pT3 disease suggests that quantitative prognostic molecular and histologic data can be obtained from a single core biopsy.

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Cushner, Fred D., David F. La Rosa, Vincent J. Vigorita, Giles R. Scuderi, W. Norman Scott, and John N. Insall. "A quantitative histologic comparison: ACL degeneration in the osteoarthritic knee." Journal of Arthroplasty 18, no. 6 (September 2003): 687–92. http://dx.doi.org/10.1016/s0883-5403(03)00256-0.

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Warren, Raphael, Vladimir Gartstein, Albert M. Kligman, William Montagna, Richard A. Allendorf, and Gregg M. Ridder. "Age, sunlight, and facial skin: A histologic and quantitative study." Journal of the American Academy of Dermatology 25, no. 5 (November 1991): 751–60. http://dx.doi.org/10.1016/s0190-9622(08)80964-4.

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Bechrakis, Nikolaos E. "Transformation of Cell Type in Uveal MelanomasA Quantitative Histologic Analysis." Archives of Ophthalmology 118, no. 10 (October 1, 2000): 1406. http://dx.doi.org/10.1001/archopht.118.10.1406.

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Hendricks, James B., and Eva M. Wojcik. "Quantitative cytology and histology by laser scanning cytometry." Clinical Immunology Newsletter 18, no. 3 (March 1998): 21–26. http://dx.doi.org/10.1016/s0197-1859(00)89168-2.

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Komitwoski, Dymitr. "Quantitative image analysis in caneer cytology and histology." Differentiation 33, no. 3 (February 1987): 280. http://dx.doi.org/10.1111/j.1432-0436.1987.tb01568.x.

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Buglioni, Alessia, Ruifeng Guo, Kandelaria M. Rumilla, Mark A. Edgar, Svetomir N. Markovic, and Gang Zheng. "An Unexpected Diagnosis Uncovered by Quantitative Molecular Findings: A Case Report." Journal of the National Comprehensive Cancer Network 21, no. 8 (August 2023): 787–91. http://dx.doi.org/10.6004/jnccn.2023.7014.

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A 74-year-old male presented with rectal pain; workup uncovered an anal mass, and a diagnosis of melanoma was rendered via histologic examination and immunohistochemical (IHC) studies. Droplet digital PCR (ddPCR)–based BRAF testing was performed and revealed the presence of BRAF V600E, which is a common targetable genetic alteration in melanoma. Interestingly, the ratio of mutant to wild-type copy number was low (0.3%), whereas tumor cell percentage on tissue slides was 90%. With additional workup, BRAF V600E IHC confirmed a very small subset of BRAF V600E–positive cells, and a next-generation sequencing (NGS) panel revealed a pathogenic KIT variant, p.L576P, with an allele frequency of 63%. It was initially hypothesized that the main driver of the melanoma was the KIT alteration, whereas a small subclone (not detected by NGS, which has a 5% limit of detection) was driven by the BRAF V600E detected by ddPCR. To determine whether there were morphologic differences between the 2 clones, a careful review of the histology was performed and revealed distinct morphology of the BRAF V600E–positive cells, including pale cytoplasm, nuclear grooves, and infiltrating eosinophils. Additional IHC workup of the BRAF V600E–positive cells showed coexpression of CD1a, Langerin, and S100, diagnostic of Langerhans cell histiocytosis (LCH). This diagnosis was unexpected and would have been missed without highly sensitive molecular testing; yet it is of clinical importance for the patient. This case raises interesting biology questions regarding the relationship between melanoma and LCH; moreover, it highlights the importance of integrating quantitative information in molecular data interpretation.

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Aeffner, Famke, Hibret A. Adissu, Michael C. Boyle, Robert D. Cardiff, Erik Hagendorn, Mark J. Hoenerhoff, Robert Klopfleisch, et al. "Digital Microscopy, Image Analysis, and Virtual Slide Repository." ILAR Journal 59, no. 1 (2018): 66–79. http://dx.doi.org/10.1093/ilar/ily007.

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Abstract Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtual slide repositories and to be viewed via computers instead of microscopes. Easier and faster sharing of histologic images for teaching and consultation, improved storage and preservation of quality of stained slides, and annotation of features of interest in the digital slides are just a few of the advantages of this technology. Combined with the development of software for digital image analysis, digital slides further pave the way for the development of tools that extract quantitative data from tissue-based studies. This review introduces digital microscopy and pathology, and addresses technical and scientific considerations in slide scanning, quantitative image analysis, and slide repositories. It also highlights the current state of the technology and factors that need to be taken into account to insure optimal utility, including preanalytical considerations and the importance of involving a pathologist in all major steps along the digital microscopy and pathology workflow.

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Uemura, Marc Isamu, Wei Qiao, Keith F. Fournier, Jeffrey Morris, Paul F. Mansfield, Cathy Eng, Richard Eldon Royal, Robert A. Wolff, Kanwal Pratap Singh Raghav, and Michael J. Overman. "Retrospective study of non-mucinous appendiceal adenocarcinomas: Role of systemic chemotherapy and cytoreductive surgery." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 263. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.263.

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263 Background: The majority of studies evaluating appendiceal epithelial neoplasms have focused on those with mucinous histology. Few studies have reported on non-mucinous appendiceal adenocarcinomas. We performed the largest single-center study to investigate this histologic subtype, in order to describe the natural history and impact of both cytoreductive surgery (CRS) and systemic chemotherapy. Methods: We retrospectively reviewed 172 pts with non-mucinous appendiceal adenocarcinoma evaluated at the UT-MD Anderson Cancer Center between 1990 and 2015. Patient demographics, tumor characteristics, therapy received, and outcomes were recorded. Response assessment was semi-quantitative (response vs. no response) according to the treating physician. Overall survival (OS) and time to progression (TTP) were calculated using Kaplan Meier product-limit method and survival rates compared using the log rank test. Results: Median age at diagnosis was 52.9 yrs (M:F 1:1). Most pts presented with advanced stage: stage I (1.7%), stage II (32.5%), stage III (14.5%), and stage IV (51.2%). No patient had well-differentiated histology. 56% had moderate and 44% poor histology. Median OS by stage was 90.9m [95% CI: 70.8 to 172.9] for stage II, 52.1m [95% CI: 28.9 to NA] for stage III and 28.3m [95% CI: 22.9 to 31.9] for stage IV, (p < 0.0001). In pts with metastatic disease (n = 128) CRS was attempted in 20 (15.6%) and was complete (CCS 0/1) in 12. The median OS for pts achieving complete CRS was 48.6m. Systemic chemotherapy was administered to 92% (118/128) of metastatic pts. The median TTP was 9.4m [95% CI: 8.0 to 11.5] and semi-quantitative response rate was 54%. The majority of pts received either oxaliplatin-based, 57%, or irinotecan-based, 23%, first-line chemotherapy regimens. No statistical difference in TTP (p = 0.9) or OS (p = 0.07) between different chemotherapies was seen. Conclusions: In contrast to mucinous appendiceal neoplasms, non-mucinous appendiceal adenocarcinomas rarely present with low-grade (well-differentiated) histology. Treatment approaches appear more akin to colorectal cancer with most metastatic pts undergoing systemic chemotherapy and a minority undergoing CRS.

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Meyramov, Gabit, Karl-Dietrich Kohnert, Vladimir Korchin, Altinay Shaibek, Gulmira Tusupbekova, and Anar Abdraimova-Meyramova. "Histophotometric complex for quantitative estimation of Insulin and Zinc Content in Pancreatic B-cells." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 100, no. 4 (December 30, 2020): 106–11. http://dx.doi.org/10.31489/2020bmg4/106-111.

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It is presented a developed and constructed histophotometric complex for quantitative evaluation in relative units of content of deposited insulin and zinc in insulin-producing B-cells of histologic preparations of pancreas. The method previously used in similar studies was based on a visual assessment of the results of coloring the preparations, or a more accurate quantitative one under the conditions of using universal complexes, including a microscope with built-in measuring devices (photometers), the disadvantage of which is, as a rule, a very high cost limiting the possibility of their use. In addition, such complexes, in connection with their universality, are not suitable for studies related to the study of the functional state of pancreatic B cells using highly specific histochemical methods for detecting insulin. The authors aimed to develop and create a studyoriented histophotometric complex of zinc and insulin in B cells, created using inexpensive components, which would help make quantitative analysis significantly more accessible to researchers working in the field of experimental diabetology.

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Foti, Pietro Valerio, Corrado Inì, Giuseppe Broggi, Renato Farina, Stefano Palmucci, Corrado Spatola, Maria Chiara Lo Greco, et al. "Quantitative Diffusion-Weighted MR Imaging: Is There a Prognostic Role in Noninvasively Predicting the Histopathologic Type of Uveal Melanomas?" Cancers 15, no. 23 (November 29, 2023): 5627. http://dx.doi.org/10.3390/cancers15235627.

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Histopathologically, uveal melanomas (UMs) can be classified as spindle cell, mixed cell and epithelioid cell type, with the latter having a more severe prognosis. The aim of our study was to assess the correlation between the apparent diffusion coefficient (ADC) and the histologic type of UMs in order to verify the role of diffusion-weighted magnetic resonance imaging (DWI) as a noninvasive prognostic marker. A total of 26 patients with UMs who had undergone MRI and subsequent primary enucleation were retrospectively selected. The ADC of the tumor was compared with the histologic type. The data were compared using both one-way analysis of variance (ANOVA) (assessing the three histologic types separately) and the independent t-test (dichotomizing histologic subtypes as epithelioid versus non-epithelioid). Histologic type was present as follows: the epithelioid cell was n = 4, and the spindle cell was n = 11, the mixed cell type was n = 11. The mean ADC was 1.06 ± 0.24 × 10−3 mm2/s in the epithelioid cells, 0.98 ± 0.19 × 10−3 mm2/s in the spindle cells and 0.96 ± 0.26 × 10−3 mm2/s in the mixed cell type. No significant difference in the mean ADC value of the histopathologic subtypes was found, either when assessing the three histologic types separately (p = 0.76) or after dichotomizing the histologic subtypes as epithelioid and non-epithelioid (p = 0.82). DWI-ADC is not accurate enough to distinguish histologic types of UMs.

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Sanchis-Alfonso, Vicente, Esther Roselló-Sastre, Carlos Monteagudo-Castro, and José Esquerdo. "Quantitative Analysis of Nerve Changes in the Lateral Retinaculum in Patients with Isolated Symptomatic Patellofemoral Malalignment." American Journal of Sports Medicine 26, no. 5 (September 1998): 703–9. http://dx.doi.org/10.1177/03635465980260051701.

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Neural damage in 16 lateral retinacula excised at the time of Insall proximal realignments or isolated lateral retinacular releases performed in patients with symptomatic patellofemoral malalignment was evaluated by means of conventional histology and immunohistochemical and morphometric analyses. A relationship between clinical and histologic findings was found. An increase in the proportion of innervated tissue was correlated with anterior knee pain syndrome. We found a significant relationship between total neural area and pain. The group with moderate pain had the highest number of nerves and the highest neural area. In reference to total neural area and pain, there was a significant difference only between the patients with moderate pain and those with light pain, but not between patients with severe pain and those with moderate pain. The group with severe pain also showed a high neural area, although with a lower number of nerves. The severe-pain group had the largest nerves (24% of nerve fibers surpassing 25 m diameter) in a zonal disposition, in which there were groups of nerve fibers in some fields and no nerve fibers in others. The group with moderate pain had an increase in medium and small nerve fibers (mean diameter, 18 m), predominantly of tiny perivascular fibers. Moreover, we believe that instability in patients with patellofemoral malalignment can be explained in part because of loss of proprioception due to neural damage.

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Ettema, Sandra L., and David P. Kuehn. "A Quantitative Histologic Study of the Normal Human Adult Soft Palate." Journal of Speech, Language, and Hearing Research 37, no. 2 (April 1994): 303–13. http://dx.doi.org/10.1044/jshr.3702.303.

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This study was designed to re-examine the same soft palates studied qualitatively in a previous investigation (Kuehn and Kahane, 1990), using a true-color image analysis system. The quantified measures of the areas of specific tissue types are reported. The results indicate that: (a) tendinous tissue is prominent anteriorly and comprises about 10% of total tissue in that region, (b) the relative proportion of glandular and connective tissue is fairly uniform across the length of the soft palate, averaging 22% and 36% respectively, (c) muscle tissue shows a pattern of increasing then decreasing amount from anterior to posterior with a maximum proportion of 23% in the midportion of the soft palate, (d) adipose tissue comprises 22% of total tissue area in the anterior segment and 17% of total tissue area in the posterior segment of the soft palate, (e) other tissue, primarily epithelium and vascular tissue, was found to be fairly constant anteriorly and increased in relative proportion to almost 30% of the total tissue area at the uvular base. The functional implications of these findings are discussed.

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Kamat, Brinda R., Stephen J. Galli, A. Clifford Barger, Lewis L. Lainey, and Kenneth J. Silverman. "Neovascularization and coronary atherosclerotic plaque: Cinematographic localization and quantitative histologic analysis." Human Pathology 18, no. 10 (October 1987): 1036–42. http://dx.doi.org/10.1016/s0046-8177(87)80220-4.

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Cook, Stephen D., Robert L. Barrack, Kevin A. Thomas, and Ray J. Haddad. "Quantitative histologic analysis of tissue growth into porous total knee components." Journal of Arthroplasty 4 (January 1989): S33—S43. http://dx.doi.org/10.1016/s0883-5403(89)80005-1.

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Zhang, Gu-Mu-Yang, Hao Sun, Bing Shi, Zheng-Yu Jin, and Hua-Dan Xue. "Quantitative CT texture analysis for evaluating histologic grade of urothelial carcinoma." Abdominal Radiology 42, no. 2 (September 8, 2016): 561–68. http://dx.doi.org/10.1007/s00261-016-0897-2.

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Origuchi, Yoshihiro, Sanji Miyoshino, Katsuhiro Mishima, and Kazunori Mine. "Quantitative histologic study of the sural nerve in Lesch-Nyhan syndrome." Pediatric Neurology 6, no. 5 (September 1990): 353–55. http://dx.doi.org/10.1016/0887-8994(90)90031-u.

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Hadlock, Tessa A., Sang W. Kim, Julie S. Weinberg, Christopher J. Knox, Marc H. Hohman, and James T. Heaton. "Quantitative Analysis of Muscle Histologic Method in Rodent Facial Nerve Injury." JAMA Facial Plastic Surgery 15, no. 2 (March 1, 2013): 141–46. http://dx.doi.org/10.1001/jamafacial.2013.430.

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Chamgoulov, Ravil, Pierre Lane, and Calum MacAulay. "Optical Computed-Tomographic Microscope for Three-Dimensional Quantitative Histology." Analytical Cellular Pathology 26, no. 5-6 (January 1, 2004): 319–27. http://dx.doi.org/10.1155/2004/209579.

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A novel optical computed‐tomographic microscope has been developed allowing quantitative three‐dimensional (3D) imaging and analysis of fixed pathological material. Rather than a conventional two‐dimensional (2D) image, the instrument produces a 3D representation of fixed absorption‐stained material, from which quantitative histopathological features can be measured more accurately. The accurate quantification of these features is critically important in disease diagnosis and the clinical classification of cancer. The system consists of two high NA objective lenses, a light source, a digital spatial light modulator (DMD, by Texas Instrument), an x–y stage, and a CCD detector. The DMD, positioned at the back pupil‐plane of the illumination objective, is employed to illuminate the specimen with parallel rays at any desired angle. The system uses a modification of the convolution backprojection algorithm for reconstruction. In contrast to fluorescent images acquired by a confocal microscope, this instrument produces 3D images of absorption stained material. Microscopic 3D volume reconstructions of absorption‐stained cells have been demonstrated. Reconstructed 3D images of individual cells and tissue can be cut virtually with the distance between the axial slices less than 0.5 μm.

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Coerdt, Wiltrud, Helga Rehder, Irene Gausmann, Reiner Johannisson, and Alfred Gropp. "Quantitative Histology of Human Fetal Testes in Chromosomal Disease." Pediatric Pathology 3, no. 2-4 (January 1985): 245–59. http://dx.doi.org/10.3109/15513818509078785.

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47

SIFRE, L., J. P. COTON, B. ANDRÉ, and Z. ŘEZÁČOVÁ-LUKÁŠKOVÁ. "Optimization of a quantitative method for muscle histology assessment." Journal of Microscopy 250, no. 1 (February 14, 2013): 50–56. http://dx.doi.org/10.1111/jmi.12016.

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Fan, Rong, David Grignon, Erol E. Gulcicek, Philip Faught, and Liang Cheng. "Proteomic studies of Anaplasia in Wilms Tumor." Proteomics Insights 4 (January 2011): PRI.S7466. http://dx.doi.org/10.4137/pri.s7466.

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Wilms tumor is the most common malignant tumor in the pediatric kidney. Anaplasia, focal or diffuse as defined by histological criteria, is the most important parameter to guide the clinical treatment plan. We sought to identify and characterize potential useful biomarkers associated with anaplasia and provide insight into the peculiar molecular biology of Wilms tumor with unfavorable histology. Utilizing isobaric tagging technology for relative and absolute quantitation, coupled with tandem mass spectrometry, we identified proteins that are differently regulated in different Wilms tumor histologies. Four Wilms tumor specimens were selected, including two with classic favorable histology, one with focal anaplasia, and one with diffuse anaplasia. A total of 256 proteins with a Protein Score >1.0 are identified from all samples (proteins with >90% confidence). Compared with classic favorable morphology: in the focal anaplasia group, we identified a total of 26 proteins of which six were underexpressed and 20 were overexpressed; in the diffuse anaplasia group, we identified a total of 20 proteins of which eight were underexpressed and 12 were overexpressed. With a total of 39 involved proteins, seven were common to both the focal and diffuse anaplasia cases, and clearly seemed to have a similar regulation. The newly identified potential markers for Wilms tumor with unfavorable histology include ENO1, GAPDH, ALDOA, SLC25A6, LDHA, PGAM1, MIF, RBP1, HBA, HP, COL1A1, CFL1, and FSCN1 etc. In Wilms tumors, though there are unfavorable histology differences (focal or diffuse anaplasia), the protein expression seems to be similarly dysregulated compared with the favorable histology group. The newly identified potential markers may provide insights into the molecular biology of Wilms tumor and may have practical implications.

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Kim, Dong-Eog, Jeong-Yeon Kim, Dawid Schellingerhout, Soo-Min Shon, Sang-Wuk Jeong, Eo-Jin Kim, and Woo Kyung Kim. "Molecular Imaging of Cathepsin B Proteolytic Enzyme Activity Reflects the Inflammatory Component of Atherosclerotic Pathology and Can Quantitatively Demonstrate the Antiatherosclerotic Therapeutic Effects of Atorvastatin and Glucosamine." Molecular Imaging 8, no. 5 (September 1, 2009): 7290.2009.00027. http://dx.doi.org/10.2310/7290.2009.00027.

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Inflammation in atherosclerotic plaques causes plaque vulnerability and rupture, leading to thromboembolic complications. Cathepsin B (CatB) proteases secreted by macrophages play a major role in plaque inflammation. We used a CatB-activatable near-infrared fluorescence (NIRF) imaging agent to demonstrate the inflammatory component in mice atheromata and the atherosclerosis-modulating effects of atorvastatin or glucosamine treatments. Apolipoprotein E knockout mice ( n = 35) were fed normal chow, a Western diet, a Western diet + atorvastatin, a Western diet + glucosamine, or a Western diet + atorvastatin + glucosamine for 14 weeks. Twenty-four hours after the intravenous injection of a CatB-activatable probe, ex vivo NIRF imaging of the aortas and brains was performed, followed by histology. The CatB-related signal, observed in the aortas but not in the cerebral arteries, correlated very well with protease activity and the presence of macrophages on histology. Animals on Western diets could be distinguished from animals on a normal diet. The antiatherosclerotic effects of atorvastatin and glucosamine could be demonstrated, with reduced CatB-related signal compared with untreated animals. Plaque populations were heterogeneous within individuals, with some plaques showing a high and others a lower CatB-related signal. These differences in signal intensity could not be predicted by visual inspection of the plaques but did correlate with histologic evidence of inflammation in every case. This suggests that vulnerable inflamed plaques can be identified by optical molecular imaging.

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Delano, E. Olutayo, Don Tyndall, John B. Ludlow, Martin Trope, and Claus Lost. "Quantitative radiographic follow-up of apical surgery: A radiometric and histologic correlation." Journal of Endodontics 24, no. 6 (June 1998): 420–26. http://dx.doi.org/10.1016/s0099-2399(98)80025-3.

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