Dissertations / Theses on the topic 'Hip structure analysis'
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Khoo, Benjamin Cheng Choon. "Clinical and phantom-based studies of the validity and value of quantitative radiological hip structural analysis." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0189.
Full textCaliskan, Fatma. "Electromagnetic Analysis of Planar Layered Structures." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5116.
Full textBehrens, Anna-Janina. "Fine structure of the HIV-1 glycan shield." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:3cec0ef7-c305-411e-a76b-125d5e7e9954.
Full textVidimar, Vania. "Characterization of the anticancer properties of Ruthenium-derived compounds : mode of action, optimization and development of experimental tools." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ105.
Full textIn recent years, a new class of anticancer ruthenium-based drugs, called RDCs (Ruthenium-Derived Compounds), has been developed to overcome the limitations of classic platinum chemotherapeutics. Unlike the latter, the anticancer activity of RDCs is in part independent of DNA interaction. Therefore, the main objective of my thesis work was to elucidate the molecular mechanisms involved in RDCs anticancer and antimetastatic activity beyond DNA damage. I demonstrated that RDC11, unlike cisplatin, affects the HIF-1 and mTOR signaling pathways, two pathways that play a key role in cellular metabolism and that are frequently altered in cancer cells. In parallel, I performed a structure/activity analysis to select new RDCs endowed with better chemical and pharmacological properties than RDC11. This study allowed to identify two novel RDCs that reduce tumor growth in vivo at much lower doses than RDC11 and that induce cancer cell death by an overproduction of reactive oxygen species and activation of caspase 8. In conclusion, my work led to the identification of new mechanisms underlying the anticancer activity of RDC11 that could explain some of the differences between the mode of action of RDC11 and cisplatin. In addition, it allowed to select two novel RDCs which are more effective than RDC11. These results have a significant impact on the development of new anticancer or antimetastatic therapies
Zeffman, Amanda Tracey. "NMR analysis of the three-dimensional structure of the HIV-1 encapsidation signal." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621828.
Full textAbrams, Nicola Elaine. "The structure & desorption of molecular species from single crystal metal surfaces." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387862.
Full textDubanchet, Vincent. "Modélisation et contrôle d’un robot spatial flexible pour la capture d’un débris en rotation." Thesis, Toulouse, ISAE, 2016. http://www.theses.fr/2016ESAE0022/document.
Full textOn-orbit debris are currently causing deep concern for space agencies, related companies, and also among the population. ¿is is evidenced by the numerous scientific articles and recent movies on the matter. Indeed, these objects pose a serious threat for the astronauts on mission and for operational satellites. Among the various technical concepts already designed to address these threats, this thesis focuses on space robotics. Tools and methods are thus introduced for the modeling and control of a chaser satellite equipped with a manipulator. Dynamic models and optimized simulation schemes are developed to handle any multi-body system made up of amoving base embedding various appendages, either rigid or flexible. ¿en, a trajectory planner is designed to ensure acceleration continuity with the natural motion of the debris in order to perform a soft capture. ¿is reference trajectory is tracked by the end-effector of the chaser using a two-level control law, which is tuned by the structured H1 synthesis. A robustness analysis is also presented to assess the stability and the performances of the closed-loop system with respect to the motion of the robotic arm. Finally, the outcome of the thesis is validated by a twofold approach: by numerical means with a highfidelity simulator, and by practical ones with a robotic test bench including physical components in real time
Cirino, Nick Mario. "Structure-function analysis of the ribonuclease-H domain of human immunodeficiency virus type-1 reverse transcriptase." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062096231.
Full textMathu, Alexander Muchugia Nganga. "Structural analysis of effects of mutations on HIV-1 subtype C protease active site." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004073.
Full textTie, Yunfeng. "Crystallographic Analysis and Kinetic Studies of HIV-1 Protease and Drug-Resistant Mutants." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_diss/2.
Full textNnyanzi, David. "The Role of Structural Factors in HIV Transmission in Uganda: a Multi-Level Analysis." Thesis, Boston College, 2011. http://hdl.handle.net/2345/2365.
Full textSince the early 1980s, Uganda has been in the spotlight of global concerns about the HIV/AIDS epidemic that has almost brought the country to its knees. Consequently, a number of social epidemiologists and researchers from different social science fields have, over the past two and half decades, focused their attention on Uganda, attempting to identify the risk factors that expose people to HIV infection in order to inform intervention policy. Although studies coming out of this effort have provided important insights into risks of HIV infection, they have been criticized for almost entirely focusing on individual behavioral factors, such as prostitution and inconsistent condom use, as the primary causal factors of HIV infection, without comprehending the contextual background in which HIV infection takes place. Using the 2000/01 Uganda Demographic and Health Survey and employing multilevel logistic regression methods, I address this concern by investigating the influence of contextual factors on three behaviors related to the risk of HIV infection (HIV testing, multiple sexual partnering, and inconsistent condom use). Analyses reveal that educational attainment, socioeconomic status, and religion significantly predict HIV testing, multiple sexual partnering, and condom use for both men and women - and at both the individual and neighborhood levels. Analyses also reveal that age has an inverted U-shaped association with HIV testing and multiple sexual partnering for both men and women at the individual level. Despite important gains in slowing HIV infection rates over the past two decades, Uganda's increasing burden of the HIV/AIDS epidemic - amid faltering healthcare and other social services investments - is inevitable. It is apparent that there are formidable obstacles to effectively eradicating HIV/AIDS, unless essential social services - such as education, accessible healthcare services - are enhanced, and policies are introduced to improve socioeconomic status of individuals and entire neighborhoods
Thesis (PhD) — Boston College, 2011
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Sociology
Aschman, Nicolas. "Analyses structurelles et fonctionnelles de l'intéraction de la tétherine avec le récepteur ILT7." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV064/document.
Full textHuman immunodeficiency virus 1 (HIV-1) specifically infects CD4+ T cells, thereby preventing an appropriate activation of cytotoxic T cells and B cells in response to opportunistic pathogens. In addition, HIV-1 antagonises host restriction factors, including tetherin. In the absence of the viral protein Vpu, tetherin potently inhibits virus particle release from infected cells. Tetherin also triggers proinflammatory signaling upon sensing virus assembly, and activates the dendritic cell receptor ILT7. The principal objective of this thesis was to elucidate the structural details underlying the interaction of tetherin with ILT7. Despite difficulties in the production of recombinant ILT7, the crystal structure of the N-terminal ILT7 domain could be determined. Furthermore, binding of tetherin to full-length ILT7, but not to the N-terminal domain, could be confirmed by SPR. These results provide a solid basis for the more detailed characterisation of the interaction
Münter, Sylvia Gabriele. "Analysing the role of a cellular mechanism in HIV infection and evaluation of novel antiviral compounds." Paris 11, 2004. http://www.theses.fr/2004PA112103.
Full textHIV is the causative agent of the acquired immunodeficiency syndrome (AIDS). For the development of novel antiviral compounds, understanding of the lifecycle as well as the molecular mechanisms of host pathogen interactions are a prerequisite. A particular feature of lentiviruses is the active transport of the pre-integration complex (PIC) into the nucleus. The mechanism remains elusive, yet in the case of HIV Vpr is one candidate possibly implicated in the process. The protein stays associated to the PIC until nuclear translocation. It has been shown, that Vpr binds to the nuclear pore complex. This interaction might therefore be the link mediating import of the PIC. Moreover the cytoskeleton has been shown to play a major role in cytoplasmic transport of viral particles. In this context, we observed the nuclear envelope (NE) to be embedded in a perinuclear actin shell and displaying highly dynamic nuclear invaginations. We developed a novel approach to visualize actin inside living cells and thus we could show a high turnover actin pool around the NE and inside NE invaginations of living cells. Although reported in different cell types, the possible role of perinuclear actin filaments in the dynamic structural plasticity of the NE remains unresolved. We could show that NE-membranes alone are sufficient to nucleate polymerizing actin filaments in vitro, involving both actin recruitment to their surface, and filament growth. Accordingly, our results demonstrate that perinuclear actin dynamics are orchestrated by the NE itself. By binding of Vpr to the NPC, the virus could possibly exploit this pool of polymerizing actin as a new strategy to overcome the nuclear membrane
St, Pierre Valessa. "Quality of Life in Older African American Men Living with HIV/AIDS: A Structural Equation Analysis." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1308261830.
Full textJames, Colin Hugh. "X-ray structure analysis of HIV-1 and SIV proteinase co-crystallized with isovaleryl pepstatin : conformational variability among inhibitor complexes." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312710.
Full textStephenson, James David. "Structural analysis of the HIV-1 5' untranslated region RNA by single molecule FRET and molecular modelling." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610361.
Full textRoyer, Loic. "Unraveling the Structure and Assessing the Quality of Protein Interaction Networks with Power Graph Analysis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-62562.
Full textBennett, A. E. "Structural analysis of an HIV-neutralizing protein and its complex with native viral gp120 : implications for antiviral drug design." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596573.
Full textZhao, Zhong. "Part I. Structure-function studies of adenylate kinase with unnatural amino acids. Part II. Structure-function studies of phosphatidylinositol-specific phospholipase C: Kinetic analysis and the roles of His-32 and Asp-274 /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794273980584.
Full textYang, LIngchun. "NMR analysis of structural features of the HIV-1 nucleocapsid protein in response to mutation and interaction with RNA and drug candidates." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.
Full textSheik-Amamuddy, Olivier. "Structural analysis of proteases from South African HIV-1 (subtype C) patients undergoing Lopinavir treatment, using comparative modeling, ligand-docking and molecular dynamics." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/4931.
Full textSchürig, Margitta Verfasser], and Wulf [Akademischer Betreuer] [Blankenfeldt. "Efficient expression of viral surface proteins by transient gene expression in Hi5 insect cells for functional and structural analysis / Margitta Schürig ; Betreuer: Wulf Blankenfeldt." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1176701274/34.
Full textZheng, Yue. "Identification d'une plante médicinale africaine par le DNA barcoding et étude de composés à activité anti-HIV de cette plante." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ095/document.
Full textMy thesis project deals with the identification, by DNA barcoding, of an African medicinal plant and the study of anti-HIV compounds from this plant. A first analysis of the ITS2 marker sequence determined from DNA extracted from the wood suggested that the plant could belong to the Cassia or the related Senna genus. A further analysis of ITS2 as well as of trnH-psbA spacer sequences from about 50 species of the two genera allowed me to identify the plant as Cassia abbreviata. The sequence alignments, which reveal unique features present in the Cassia but not the Senna sequences, were used to construct phylogenetic trees showing the clear separation of the species of the Cassia and the Senna genus. The two markers therefore allow a quick discrimination between the species of the Cassia and the Senna genus and appear to be excellent barcode markers for identification of these species. Following the identification of the plant I have tested the crude ethanol extract as well as 57 purified compounds from the plant for an anti-HIV activity. The extract, as well as one of the compounds, namely piceatannol, showed a broad spectrum of antiviral activities for HIV and HSV. They inhibited HIV-1 infection at the early stage against various reference strains and resistant clinical isolates independent of the co-receptor usage (IC50: 10.47-40.77 μg/ml, CC50>1000 μg/ml; IC50: 8.04-47.46 μM,CC50>300 μM, respectively). Neither the crude extract nor piceatannol had an effect on CD4 and CCR5/CXCR4. The crude extract blocked CD4-gp120 interaction while piceatannol did not, indicating that CE may target gp120 and piceatannol may act as a non-specific viral attachment inhibitor. Moreover, piceatannol inhibited HIV infection of TZM-Bl target cells in an in vitro female genital tract model and did not activate PBMCs, suggesting that it may represent a good candidate as microbicide. Other anti-HIV compounds found in Cassia abbreviata include oleanolic acid, palmitic acid, taxifolin and three other compounds the structure of which is presently being elucidated
Delmotte, Nausicaa. "Identifications croisées multi-longueurs d'ondes : Application aux populations stellaires des nuages de Magellan et aux étoiles jeunes de notre galaxie." Phd thesis, Université Louis Pasteur - Strasbourg I, 2003. http://tel.archives-ouvertes.fr/tel-00004238.
Full textMu-ChunYang and 楊牧君. "Stress Analysis Application of Additive Manufactured Hip Prosthesis with Porous Structures." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/r43mws.
Full text國立成功大學
材料科學及工程學系
106
For patients recovering from total hip replacement surgery, the stress shielding effect, which is caused by a difference in Young’s modulus between the hip prosthesis and human bone, can lead to prosthesis loosening or dislocation. Additive manufacturing technology, such as electron beam melting (EBM), is mature enough to fabricate porous structures made of Ti6Al4V alloy. This thesis studies the mechanical properties of porous structures and their application to artificial hip prostheses using the finite element method. The study is divided into two parts. The first part establishes the simulation method and the second part discusses the application of the simulation results to hip prostheses. The simulation and experimental results of the Young’s modulus of carbon steel show a very small deviation of about 0.7%. Porous samples with various pore geometries show the trend that higher relative density is accompanied by higher Young’s modulus in both simulation and experiments. Several unit cell structures were chosen for further mechanical simulation. The diagonal unit cell was found to be the most stable. Various compression load, Young’s modulus of cement, hip prosthesis outlook were simulated based on ISO 7206-4. The results show that when the porous structures were applied in a hip prosthesis, the stress concentration value decreased.
Huang, Yi-Han, and 黃奕涵. "Analysis of WLAN Dual - band Antenna with HIS Structure." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/22862421143171455582.
Full text國立雲林科技大學
電機工程系碩士班
101
In recently years, smart phones and tablet PCs have become more and more popular because of the fast development of wireless networks. Because of the almost ubiquitous wireless local area networks (WLANs) in urban areas, more and more wireless products support the communication through WLANs. These wireless products will be inevitable to generate electromagnetic waves that may cause adverse effects on human bodies. Hence, how to reduce undesirable electromagnetic radiations has become an important research topic in the area of electromagnetic compatibility (EMC). The thesis proposes a dual-band electromagnetic protection sheet that can be used for the 2.45- and 5.25-GHz WLAN applications. The proposed electromagnetic protection sheet, which is a high-impedance surface (HIS), can be used in conjunction with a dual-band antenna to reduce the radiation in undesired directions while not to downgrade the radiation in the desired direction. The dual-band monopole antenna and dual-band HIS were both designed using the simulator Ansoft HFSS. The reflection coefficient, radiation pattern, total radiated power (TRP), horizon radiated power (HRP), and near-horizon partial radiated power (NHPRP) are all simulated with and without the presence of the HIS. To verify that the designed dual-band monopole antenna in the presence of the dual-band HIS can indeed reduce adverse effects on human bodies, we established a human-head model to simulate the specific absorption rate (SAR). The resulting SAR values are found to be lower than the limits specified by the regulations. In comparison with other types of electromagnetic protection sheets, it is also found that HISs are more valuable in practical applications.
Shang, Lei active 2013. "Improving secondary structure prediction with covariation analysis and structure-based alignment system of RNA sequences." 2013. http://hdl.handle.net/2152/23111.
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Patel, Siddharth. "Computational Analyses of Protein Structure and Immunogen Design." Thesis, 2015. http://etd.iisc.ernet.in/2005/3979.
Full textBrucz, Kimberly Anne. "HIF prolyl 4-hydroxylase (PHD) activity and the structure analysis blueprints for development of specific substrate inhibitors /." 2005. http://wwwlib.umi.com/dissertations/fullcit/1426751.
Full textTitle from PDF title page (viewed on Feb. 3, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: L. Wayne Schultz. Includes bibliographical references.
Baharuddin, Aida [Verfasser]. "Crystallographic analysis of the molecular evolution of HIV-1 proteinase : structure correlates with viral fitness / vorgelegt von Aida Baharuddin." 2007. http://d-nb.info/986506664/34.
Full textSong, Kyung Tae Kevin. "Saccharomyces cerevisiae: A Platform for Structure-activity Relationship Analysis and High-throughput Candidate Prioritization." Thesis, 2013. http://hdl.handle.net/1807/35690.
Full textRoyer, Loic. "Unraveling the Structure and Assessing the Quality of Protein Interaction Networks with Power Graph Analysis." Doctoral thesis, 2010. https://tud.qucosa.de/id/qucosa%3A24399.
Full textChen, Langtao. "Essays on Health Information Technology: Insights from Analyses of Big Datasets." 2016. http://scholarworks.gsu.edu/cis_diss/60.
Full textΓαλανάκης, Πέτρος. "Αποτίμηση των καθοριστικών παραγόντων της δομής και της αλληλεπίδρασης πεπτιδικών τμημάτων της HIV-1 gp120 V3 περιοχής και του CCR5 συνυποδοχέα των Τ-λεμφοκυττάρων με χρήση φασματοσκοπίας NMR." Thesis, 2009. http://nemertes.lis.upatras.gr/jspui/handle/10889/4107.
Full textThe obstruction of a cell infection by HIV is succeeded either by inhibiting the interaction between the viral gp120 and the CD4 cell receptors or by preventing the gp41 action and deterring the conjuction of gp120 with the CXCR4 and CCR5 chemokine receptors. The role that chemokines and their receptors play at the process of signal transmission, through which the apoptotic mechanisms of non HIV infected cells are activated, appoints the gp120-CCR5/CXCR4 interaction as a highly attractive scientific target for the design of HIV-1 life cycle inhibitors. According to numerous immunological, physicochemical and structural studies the PND V3 region of gp120 and the extracellular N-terminal peptide fragment of CCR5 coreceptor constiture the primary regions that are involved in the interactions of occurring between the two proteins. The sequence variation of the PND V3 region and its correlation with the adopted conformation, the dependence of the position and type of amino-acid with the intensity of the interaction and the linkage of viral tropism with the peptides biologically active conformation comprise fundamental stages in the process of understanding the mechanism of gp120 – CCR5 interaction and the elements that designate it. The thesis interest was oriented towards this direction while its primary targets were the evaluation of the interaction determinants by using peptide fragments, the designation of the interaction type and the calculation of the specific peptides structures through the use of Nuclear Magnetic Resonance Spectroscopy. As expected for free peptides in solution, the peptides representing the PND V3 region of gp120 exhibit conformational flexibility, but they exhibited a large number of NOEs which allowed convergence to a specific conformation. The PND V3 peptides retain the U-turn conformation observed in the crystal structures of gp120 complexes independently of CCR5 presence. The interaction of different regions of the CCR5Nt peptide is gradually increasing proportionally to the positive charge increase in the V3 peptides. The data demonstrate that the PND V3 and CCR5Nt peptide sequences have propensities for interaction and that their binding and selectivity is determined by simple electrostatic attraction mechanisms. The thesis conclusions combined to those extracted by many biological, biochemical and physicochemical studies bring forth new data that can be used in the rational design of inhibitors that will exhibit increased binding affinity for CCR5 co-receptor.
Jeffrey, Annah Mandu. "A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy." Thesis, 2006. http://hdl.handle.net/2263/30379.
Full textThesis (PhD)--University of Pretoria, 2006.
Electrical, Electronic and Computer Engineering
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