Dissertations / Theses on the topic 'High susceptibility'
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Wharton, Samuel James. "Susceptibility mapping in high field MRI." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/13074/.
Full textBulow, Barbara A. "HIV susceptibility among high-risk adolescents." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115725.
Full textDepartment of Educational Psychology
Pathmanathan, N. "A.C. magnetic susceptibility of high-Tc superconductors." Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332772.
Full textEl-Abbar, Abdallah Abdulwanis. "AC susceptibility studies of high-Tâ†c superconductors." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357929.
Full textSalim, Maan. "The AC magnetic susceptibility of high temperature superconductors." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270233.
Full textFigueroa-Gordon, Douglas J. "Hydrogen re-embrittlement susceptibility of ultra high strength steels." Thesis, Cranfield University, 2005. http://dspace.lib.cranfield.ac.uk/handle/1826/1433.
Full textTruong, Trong-Kha. "Susceptibility effects in ultra-high field magnetic resonance imaging of the human brain." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1093830567.
Full textJönsson, Johan. "High precision Ac susceptibility : a probe to exchange bias, and flux creep in high-Tc materials /." Stockholm, 1998. http://www.lib.kth.se/abs98/jons1211.pdf.
Full textParboosingh, Jillian S. "Biochemical and molecular analysis of monoamine oxidase in alcoholics, high risk subjects and low risk controls." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61088.
Full textSutton, Benjamin James. "Solidification Behavior and Hot Cracking Susceptibility of High Manganese Steel Weld Metals." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366302517.
Full text俞大風 and Tai-fung Yu. "An analysis of electrical transport and magnetic susceptibility properties of YBa2Cu3O7-[delta] and La2-xSrxCuO4 high Tcsuperconductors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31238014.
Full textDI, MECO ANTONIO. "EFFECT OF GESTATIONAL HIGH FAT DIET ON ALZHEIMER’S DISEASE SUSCEPTIBILITY IN THE OFFSPRING." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/598730.
Full textPh.D.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting over five million people in the US alone. Causes for the most common sporadic form of the disease are still obscure and no therapeutic approach is available to halt the progression of AD. Subjects whose mothers were affected by sporadic AD are three times more susceptible to develop the disease later in life compared to subject from sporadic AD fathers. However, the mechanisms of maternal transmissibility for sporadic AD are unknown. Lifestyle and nutrition are important risk factors for sporadic AD. Direct exposure to saturated fats and cholesterol is positively correlated to AD development later in life. We hypothesized that maternal exposure to high-fat diet throughout gestation would affect AD susceptibility in the offspring later in life. To tackle this biological question, triple transgenic (3xTg) dams carrying human APP (KM670/671NL), PSEN1 (M146V) and MAPT (P301L) mutations together with wild type da
Temple University--Theses
Yu, Tai-fung. "An analysis of electrical transport and magnetic susceptibility properties of YBa2Cu3O7-[delta] and La2-xSrxCuO4 high Tc superconductors /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19036607.
Full textLabreche, Karim. "Genetic Susceptibility and Molecular Characterization of Glioma." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS161/document.
Full textGliomas are the most common adult malignant primary tumour of the central nervous system. Thus far, no environmental exposures has been linked to risk except for ionizing radiation, which only accounts for a very small number of cases. Direct evidence for inherited predisposition to glioma is provided by a number of rare inherited cancer syndromes, such as Turcot's and Li–Fraumeni syndromes, and neurofibromatosis. Even collectively, these diseases however account for little of the twofold increased risk of glioma seen in first-degree relatives of glioma patients. My research was centred on two complementary research activities: Identifying susceptibility genes for glioma to delineate key biological pathways contributing to disease pathogenesis and to identify new recurrent mutated genes for glioma to provide for further insights into glial oncogenesis and suggesting targets for novel therapeutic strategies. Collectively the findings in this thesis provide increased insight into the nature of genetic predisposition to glioma and substantiate the often distinct associations between susceptibility variants and glioma molecular groups. In addition the discovery of a new mutated gene in glioma offers the potential to support drug development and advance precision medicine for this tumours
Bracanovic, Darko. "Ac susceptibility and resistivity studies of YBaâ†2Cuâ†3Oâ†7â†-â†#delta# high-temperature superconductors." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302027.
Full textFlinkfeldt, Linnea. "High throughput pipeline for rapid antibiotic susceptibility testing and ID of bacteria from blood cultures." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-388251.
Full textMånsson, Daniel. "Intentional electromagnetic interference (IEMI) : Susceptibility investigations and classification of civilian systems and equipment." Doctoral thesis, Uppsala universitet, Elektricitetslära, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9264.
Full textJahn, Peter Thomas [Verfasser], Guy D. [Akademischer Betreuer] Moore, and Jens [Akademischer Betreuer] Braun. "The Topological Susceptibility of QCD at High Temperatures / Peter Thomas Jahn ; Guy D. Moore, Jens Braun." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1201820626/34.
Full textBlanco-Vogt, Ángela. "Methodology for high resolution spatial analysis of the physical flood susceptibility of buildings in large river floodplains." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-201193.
Full textIn vielen Städten nehmen die Auswirkungen von Hochwasser auf Gebäude aufgrund immer extremerer Wetterereignisse, unkontrollierbarer Siedlungsbauten und der steigenden Vulnerabilität von Besitztümern stetig zu. Es existieren zwar bereits Ansätze zur Beurteilung von Wasserschäden an Gebäuden und Infrastrukturknotenpunkten. Doch ist es bisher schwierig, diese Methoden großräumig anzuwenden, da es an einer präzisen Klassifizierung und Charakterisierung von Gebäuden und anderen baulichen Anlagen fehlt. Zu diesem Zweck sollen in dieser Arbeit erstens ein Konzept für ein genaueres Verständnis der physischen Vulnerabilität von Gebäuden gegenüber Hochwasser dargelegt, zweitens ein methodisches Verfahren zur Kombination der bestehenden Methoden und Hilfsmittel mit dem Ziel einer großräumigen und hochauflösenden Analyse erarbeitet und drittens diese Methode an drei Pilotstandorten mit unterschiedlichem Ausbauzustand erprobt werden. Die Rahmenbedingungen des Konzepts grenzen die Begriffe der Vulnerabilität, der physischen Vulnerabilität und der physischen Anfälligkeit gegenüber Hochwasser ein und erörtern deren Beziehung zur sozialen und ökonomischen Vulnerabilität. Es werden die Merkmale der physischen Anfälligkeit von Gebäuden gegenüber Hochwasser als Bestandteil der Vulnerabilität definiert. Das methodische Verfahren umfasst drei Module: (i) Methoden zur Erstellung einer Gebäudetypologie, (ii) Methoden zur Bewertung der Anfälligkeit repräsentativer Gebäude jedes Gebäudetyps und (iii) die Kombination der beiden Module mit Hilfe technologischer Hilfsmittel. Das erste Modul zur Gebäudetypologie basiert auf der Klassifizierung von Fernerkundungsdaten und GIS-Analysen anhand von sieben Gebäudeparametern, die sich für die Klassifizierung von Gebäuden bezüglich ihres Risikopotenzials bei Hochwasser als wichtig erweisen. Daraus ergibt sich ein Ansatz zur Gebäudeklassifizierung. Die anschließende Ermittlung repräsentativer Gebäude beruht auf statistischen Analysen und Zugehörigkeitsfunktionen. Das zweite Modul zur Anfälligkeit repräsentativer Gebäude beruht auf der Ableitung von Funktion von Wasserstand und physischer Einwirkung. Es setzt die relevanten Gebäudemerkmale, darunter Höhe, Maße und Materialien, in Beziehung zum erwartbaren Schaden bei unterschiedlichen Wasserständen. Die Materialanfälligkeit wird aufgrund internationaler Studien zur Festigkeit von Baustoffen sowie durch Anwendung eines Fuzzy-Logic-Expertensystems eingeschätzt. Anschließend werden Wasserstand-Schaden-Funktionen unter Einbeziehung der Hauptgebäudekomponenten berechnet, die durch unterschiedliche Wasserstände in Mitleidenschaft gezogen werden können. Funktion von Wasserstand und physischer Einwirkung dienen hier dazu, den jeweiligen Wasserstand und die physischen Auswirkung in Beziehung zueinander zu setzen. Das dritte Modul stellt die zur Umsetzung der Methoden notwendigen Hilfsmittel vor. Zur Unterstützung des automatisierten Verfahrens dienen Hilfsmittel, die die Gebäudetypologie mit der Funktion von Wasserstand und physischer Einwirkung für Gebäude in Hochwassergebieten kombinieren. Die Methoden wurden anschließend in drei hochwassergefährdeten Pilotstandorten getestet: (i) in den Siedlungsgebieten von Barrio Sur in Magangué und (ii) von La Pena in Cicuco, zwei Überschwemmungsgebiete des Magdalenas in Kolumbien, und (iii) im Stadtgebiet von Dresden, das an der Elbe liegt. Das Testverfahren umfasst die Beschreibung der Datenverfügbarkeit und genauigkeit, die einzelnen Schritte zur Analyse der. Funktion von Wasserstand und physischer Einwirkung repräsentativer Gebäude sowie die Darstellung der räumlichen Verteilung der physischen Anfälligkeit für Hochwasser. In der Diskussion wird der Beitrag dieser Arbeit zur Beurteilung der Erkenntnisse der getesteten Methoden anhand der Ziele dieser Dissertation analysiert. Die Folgerungen beleuchten abschließend die Fortschritte und auch Grenzen der Forschung hinsichtlich methodischer und empirischer Entwicklungen sowie deren allgemeine Anwendbarkeit im Bereich des Hochwasserschutzes
El impacto de las inundaciones sobre los edificios en zonas urbanas es cada vez mayor debido a la intensificación de los fenómenos meteorológicos extremos, asentamientos no controlados o no planificados y su creciente vulnerabilidad. Hay métodos disponibles para evaluar los daños por inundación en edificios e infraestructuras críticas. Sin embargo, es muy difícil implementar estos métodos sistemáticamente en grandes áreas debido a la falta de clasificación y caracterización de estructuras construidas en resoluciones detalladas. Para superar este obstáculo, este trabajo se enfoca, en primer lugar, en desarrollar un marco conceptual para comprender la vulnerabilidad y susceptibilidad física de edificios por inudaciones, en segundo lugar, en desarrollar un marco metodológico para la combinación de los métodos y herramientas para una análisis de alta resolución y en tercer lugar, la prueba de la metodología en tres sitios experimentales, con distintas condiciones de desarrollo. El marco conceptual se enfoca en comprender la vulnerabilidad y susceptibility de las edificaciones frente a inundaciones, y su relación con la vulnerabilidad social y económica. En él se describen las principales características físicas de la susceptibilidad de edificicaiones como un componente de la vulnerabilidad. El marco metodológico consta de tres módulos: (i) métodos para la derivación de topología de construcciones, (ii) métodos para evaluar la susceptibilidad de edificios representativos y (iii) la integración de los dos módulos a través herramientas tecnológicas. El primer módulo de topología de construcciones se basa en una clasificación de datos de sensoramiento rémoto y procesamiento SIG para la extracción de siete parámetros de las edficaciones. Este módulo parece ser aplicable para una clasificación de los edificios en relación con los posibles impactos de las inundaciones. El resultado es una taxonomía de las edificaciones y una posterior identificación de edificios representativos que se basa en análisis estadísticos y funciones de pertenencia. El segundo módulo consiste en el análisis de susceptibilidad de las construcciones representativas a través de funciones de profundidad del impacto físico. Las cuales relacionan los principales componentes de la construcción, incluyendo sus alturas, dimensiones y materiales con los impactos físicos a diferentes niveles de agua. La susceptibilidad del material se calcula con base a estudios internacionales sobre la resistencia de los materiales y un análisis a través de sistemas expertos difusos. Aquí, las funciones de profundidad de impacto físico son considerados como un medio para la interrelación entre el nivel del agua y los impactos físicos. El tercer módulo proporciona las herramientas necesarias para la aplicación de la metodología. Estas herramientas tecnológicas consisten en la arquitectura para la alimentación de los datos relacionados a la tipología de construcciones con las funciones de profundidad del impacto físico apoyado en procesos automáticos. La metodología es probada en tres sitios piloto: (i) en el Barrio Sur en Magangué y (ii) en la barrio de La Peña en Cicuco situado en la llanura inundable del Río Magdalena, Colombia y (iii) en barrio Kleinzschachwitz de la ciudad de Dresden, situado a orillas del río Elba, en Alemania. Las pruebas de la metodología abarca la descripción de la disponibilidad de los datos y la precisión, los pasos a seguir para obtener las funciones profundidad de impacto físico de edificios representativos y la presentación final de la distribución espacial de la susceptibilidad física frente inundaciones El discusión analiza las aportaciones de este trabajo y evalua los resultados de la metodología con relación a los objetivos. Las conclusiones del trabajo, muestran los aportes y limitaciones de la investigación en términos de avances metodológicos y empíricos y la aplicabilidad general de gestión del riesgo de inundaciones
Watkins, James Robert. "Evaluating the susceptibility of electronic components assembled with leaded solder to flexural failures, with high rate considerations." College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8861.
Full textThesis research directed by: Dept. of Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Sabahfar, Nassim. "Use of high-volume reclaimed asphalt pavement (RAP) for asphalt pavement rehabilitation." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/15107.
Full textDepartment of Civil Engineering
Mustaque Hossain
Because of recent rises in asphalt binder prices, state agencies and contractors are now willing to use higher volumes of reclaimed asphalt pavement (RAP). In this project, the effects of increasing RAP percentage and using fractionated RAP (FRAP) in hot-mix asphalt (HMA) mixtures have been studied. Fractionation involved processing and separating of RAP materials into at least two sizes, typically a coarse fraction and a fine fraction. This study evaluated the effects of increasing the proportions of RAP and FRAP on moisture resistance, rutting, and fatigue cracking of Superpave mixtures. Furthermore, the effect of using different sources of RAP in the mix has been investigated. HMA mixtures with five varying RAP and FRAP contents (20, 30, and 40% RAP, and 30 and 40% FRAP) were studied. The Hamburg wheel-tracking device (HWTD) test (TEX-242-F), the Kansas standard test method no. 56 (KT-56), or modified Lottman test, and the dynamic modulus test (AASHTO TP: 62-03) were used to predict moisture damage, rutting potential, and fatigue cracking resistance of the mixes. HMA specimens were made based on Superpave HMA mix design criteria for 12.5-mm (1/2-inch) nominal maximum aggregate size (NMAS) and compacted using the Superpave gyratory compactor. For the first source of RAP, results of this study showed that although mixture performance declined as the percentage of RAP increased, mixtures with even 40% RAP met minimum performance requirements. The second source of RAP, however, almost failed to meet minimum requirements even at 20% RAP. Results proved the maximum percentage of RAP allowed in the mix is highly influenced by its source. Although some improvements have been observed, especially for the second source of RAP, when RAP is compared to FRAP, FRAP does not seem to considerably affect performance of the HMA mixture.
Islam, R. S. "Influence of hole content and controlled disorder on the magnetic susceptibility, isotope exponents and resistivity of high-Tc cuprates." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604969.
Full textSmith, Brian Donald. "The influence of high temperature stress and herbicides on the susceptibility of creeping bentgrass (Agrostis palustris) to Curvularia lunata." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/74538.
Full textMaster of Science
Marin, Córdoba Roberto. "Chromium carcinogenesis characterization of DNA damaging intermediates by EPR ³¹P NMR, HPLC, ESI-MS and magnetic susceptibility /." Ohio : Ohio University, 2010. http://www.ohiolink.edu/etd/view.cgi?ohiou1261417590.
Full textKaskar, Rafee'ah. "Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97868.
Full textENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem. It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance and an increased disposition for the development of cardiovascular disease. Elucidation of the pathophysiological mechanisms underlying obesity and its relationship with metabolic and cardiovascular diseases is essential for prevention and management of these disorders. Melatonin, the pineal gland hormone, is a powerful antioxidant and has been shown to protect the myocardium against ischaemia/reperfusion (I/R) injury. Long- as well as shortterm melatonin treatment also reversed several of the harmful effects of obesity in an animal model of hyperphagia-induced obesity (DIO). However, its effects on myocardial I/R injury and intracellular signalling in obesity induced by a high fat diet (HFD) are still unknown. Aims of study: (i) To evaluate the ability of a high fat diet (HFD) to induce obesity in rats. Apart from evaluating its effects on the biometric parameters and resistance to ischaemia/reperfusion injury (as indicated by infarct size in regional ischaemia and functional recovery after global ischaemia), special attention will be given on the interplay between adiponectin, AMPK, leptin, and FFA in this model. (ii) To evaluate the effect of daily oral administration of melatonin to rats on the HFD as well as their littermate controls, on the parameters listed above as well as on the development of obesity. In this study melatonin will be administered from the onset of the feeding of the high fat diet. Methods: Male Wistar rats were divided into 4 groups: (i) control rats (receiving normal rat chow) (C); (ii) control rats receiving melatonin (CM); (iii) obese rats (receiving HFD) (HFD); (iv) obese rats receiving melatonin (HM). Animals were kept on the diet for 16 weeks and melatonin treatment (10mg/kg/day, added to the drinking water) started at the onset of the feeding. Following feeding and treatment, the animals were grouped into fasted/ non-fasted of which biometric parameters were recorded and blood collected at the time of sacrifice for metabolic and biochemical assays. Hearts were perfused in the working mode for evaluation of myocardial function and infarct size determination after exposure to 35min regional ischaemia/60min reperfusion. For study of intracellular signaling, hearts were perfused in the working mode, subjected to 20min global ischaemia/10min reperfusion and freeze-clamped for Western blotting. Plasma leptin, adiponectin, free fatty acid, triglycerides, total cholesterol, phospholipids, conjugated dienes and thiobarbituric reactive substances (TBARS) levels were determined. Several kinases were investigated including, the RISK (reperfusion injury salvage kinase) (PKB/Akt and ERK p44/42) and SAFE (survivor activating factor enhancement) (STAT-3) pathways, AMPK and JNK under baseline conditions or following 10 min reperfusion. In addition, expression of UCP-3 and PGC1-α was determined. Results: Significant increases in body weight, visceral fat, blood glucose, insulin, HOMA index and leptin and a reduction in adiponectin levels were observed in the fasted high fat diet (HFD) group when compared with controls (C). Significant increases in free fatty acid and triglyceride levels were also noted the HFD group while other serum lipid parameters, including TBARS, remained unchanged. No differences in functional recovery during reperfusion or infarct size after exposure to 35 min regional ischaemia, as well as functional recovery during reperfusion after 20 min global ischaemia were observed between the control and HFD groups. Baseline and 10 min reperfusion data were similar for the RISK and SAFE pathway kinases for the control vs HFD groups. The HFD also had no effect on the expression and phosphorylation of myocardial AMPK and JNK, as well as on the expression of UCP-3 and PGC1-α, when compared to the controls. Treatment with melatonin significantly reduced body weight, visceral fat, blood glucose, HOMA index and serum leptin levels in HFD treated groups, while having no effect on the lipid profile. Although melatonin significantly reduced infarct size in both control [% of area at risk: 20.59 ± 2.29 (CM) vs 38.08 ± 2.77 (C)] and high-fat diet groups [% of area at risk: 11.43 ± 2.94 (HM) vs 38.06 ± 3.59 (H)], it was without effect on myocardial functional recovery during reperfusion. Melatonin had no effect on the intracellular signaling pathways studied. Conclusions: The HFD proved to be a useful model of diet-induced obesity with a more pronounced impact on biometric and metabolic changes compared to the DIO model. Long-term melatonin treatment successfully prevented the development of metabolic abnormalities associated with the high fat diet and obesity as well as significantly reduced myocardial infarct size. The mechanisms involved in melatonin-induced cardioprotection in obesity have not been fully elucidated in this study and require further investigation. However, the anti-obesogenic and cardioprotective properties of melatonin were very significant indeed and support the suggestion of this hormone as a potential tool in the treatment of obesity and associated cardiovascular complications.
AFRIKAANSE OPSOMMING: Inleiding: Vetsug (obesiteit) het wêreldwyd epidemiese afmetings aangeneem en word tans as ‘n ‘n ernstige gesondheidsprobleem beskou. Vetsug word geassosieer met metaboliese afwykings, oksidatiewe stres, hipertensie, insulienweerstandigheid en is‘n belangrike risikofaktor vir die ontwikkeling van kardiovaskulêre siekte. Ten spyte hiervan, het onlangse studies ‘n gunstige effek van vetsug op die uitkomste van miokardiale infarksie in pasiënte gerapporteer, die sg obesiteitsparadoks. Kennis van die patofisiologiese meganismes onderliggend aan vetsug en die ontstaan van metaboliese afwykinge en hartsiekte is noodsaaklik vir die voorkoming en behandeling van hierdie toestande. Melatonien, die hormoon afgeskei deur die pineaalklier, is ‘n kragtige antioksidant en vry radikaal opruimer. Dit is voorheen aangetoon dat dit die hart teen iskemie/herperfusie (I/H) besering kan beskerm en sommige van die skadelike gevolge van vetsug in diermodelle kan omkeer. Die effek van melatonien op miokardiale I/H besering en intrasellulêre seintransduksie prosesse in vetsug geïduseer deur ‘n hoë vet dieet is egter nog onbekend. Doelstellings: (i) Die ontwikkeling en karakterisering van ‘n nuwe model van vetsug en insulienweerstandigheid geïnduseer deur 'n hoë vet dieet (HVD) en die evaluering van die effek daarvan op miokardiale I/H besering en die gepaardgaande intrasellulêre seintransduksieprosesse; (ii) Bepaling van die effek van daaglikse toediening van melatonien aan rotte op die HVD sowel as aan kontroles op ‘n standard dieet, op die ontwikkeling van dieet-geïnduseerde metaboliese veranderinge, miokardiale infarktgrootte en funksionele herstel na koronêre arterie afbinding, sowel as intrasellulêre seintransduksie. Metodiek: Vier groepe van manlike Wistar rotte is bestudeer: (i) kontrole rotte (op‘n standaard dieet) (K); (ii) kontrole rotte op ‘n standard dieet plus melatonien (KM); (iii) dieetrotte (op‘n HVD); (iv) HVD rotte wat melatonien ontvang (HM). Die HVD en melatonien (10mg/kg/dag in die drinkwater) is vir 16 weke toegedien. Na die periode van behandeling, is die diere in vastende en nie-vastende groepe verdeel, die biometriese parameters genoteer en bloedmonsters vir metaboliese en biochemiese bepalings versamel, tydens verwydering van die harte. Harte is geperfuseer volgens die werkhartmodel vir bepaling van miokardiale funksie en infarktgrootte na blootstelling aan 35min streeksiskemie. Vir evaluering van intrasellulêre seintransduksie, is geperfuseerde werkende rotharte blootgestel aan 15min globale iskemie/10 min herperfusie en gevriesklamp vir latere analises volgens die Western kladtegniek.hart. Serum leptien, adiponektien, vryvetsure, trigliseried, totale cholesterol, fosfolipiede, gekonjugeerde diene en tiobarbituursuur reaktiewe stowwe (TBARS) is bepaal. Met gebruik van Western kladtegniek, is die aktivering en/of uitdrukking van die RISK (PKB/ Akt en ERK p44/42) en SAFE (STAT-3) seintransduksiepaaie, AMPK, JNK, UCP-3 en PGC1-α, onder basislyn toestande of na 10 min herperfusie bestudeer. Resultate:‘n Beduidende toename in liggaamsgewig, visserale vet, die HOMA indeks, insulien en leptien vlakke is in die HVD groep waargeneem vergeleke met die kontrole (K) rotte. Adiponektien vlakke was laer in die HVD groep. Die HVD groep is ook gekenmerk deur ‘n beduidende styging in serum vryvetsuur en trigliseried vlakke, terwyl die ander lipied parameters, insluitende die TBARS vlakke, onveranderd was. Infarktgrootte en funksionele herstel tydens herperfusie na blootstelling aan 35 min streeksiskemie, asook funksionele herstel tydens herperfusie na 20 min globale iskemie het nie verskil tussen harte van die kontrole en HVD rotte nie. Aktivering van PKB/Akt, ERK p44/p42, STAT3, AMPK en JNK by basislyn en na 10 min herperfusie was soortgelyk in die kontrole en HFD groepe. Die HVD het ook geen effek op die uitdrukking van UCP-3 en PGC1-α in vergelyking met die kontrole gehad nie. Behandeling met melatonien het die liggaamsgewig, visserale vet, bloedglukose, HOMA indeks en serum leptien vlakke in die HVD groepe statisties beduidend verlaag, terwyl dit geen invloed op die lipiedprofiel gehad het nie. Melatonien behandeling het die miokardiale infarktgrootte beduidend en tot dieselfde mate verminder in beide kontrole [20.59 ± 2.29 (KM) vs 38.08 ± 2.77% (K)] en HVD groepe [11.43 ± 2.94 (HM) vs 38.06 ± 3.59% (HVD)]. Geen verskille is egter tussen die funksionele herstel gedurende herperfusie van die behandelde en onbehandelde kontrole en HVD groepe waargeneem nie. Melatonien het ook geen uitwerking op die intrasellulêre seintransduksiepaaie gehad nie. Gevolgtrekkings: Die resultate het getoon dat die HFD 'n goeie model van dieetgeïnduseerde vetsug en insulien weerstandigheid ontlok, met 'n meer uitgesproke impak op biometriese en metaboliese veranderinge as die voorheen gebruikte hoë-sukrose dieet. Langtermyn melatonien- behandeling het die ontwikkeling van metaboliese abnormaliteite geassosieer met die HVD, voorkom, asook miokardiale infarktgrootte na koronêre afbinding beduidend verminder. Die meganismes betrokke in melatonien-geïnduseerde miokardiale beskerming moet egter in meer detail ondersoek word. Die resultate verkry steun die voorstel dat melatonientoediening voordelig sal wees in die behandeling van vetsug en sy kardiovaskulêre komplikasies.
Farmer, Samantha. "Analysis and Risk Estimation of High Priority Unstable Rock Slopes in Great Smoky Mountains National Park, Tennessee and North Carolina." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3953.
Full textCevik, Gul. "Investigation Of The Effect Of Orientation And Heat Treatment On The Stress Corrosion Cracking Susceptibility Of 7050 Aluminum Alloy." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/3/12605220/index.pdf.
Full textWokoma, Ekanem C. W. "The effects of high temperature stress and nutrient release from maize (Zea mays L.) leaves on susceptibility to Bipolaris maydis (Nisikado) Shoemaker /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487323583623123.
Full textKasch, Juliane [Verfasser], and Susanne [Akademischer Betreuer] Klaus. "Impact of maternal high-fat consumption on offspring exercise performance, skeletal muscle energy metabolism, and obesity susceptibility / Juliane Kasch ; Betreuer: Susanne Klaus." Potsdam : Universität Potsdam, 2018. http://d-nb.info/1218403527/34.
Full textLe, Poul Nicolas. "Charge transfer at the high-temperature superconductor/liquid electrolyte interface." Thesis, University of Exeter, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391279.
Full textNwabueze, Christian, Liang Wang, Fenose Osedeme, Michelle McNabb, Joshua Yang, Rafie Boghozian, David Wood, and Hadii Mamudu. "Understanding the association between susceptibility to smoke e-cigarettes and the actual use of e-cigarette among school-going youths in rural appalachia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/7675.
Full textFahlström, Karl. "Laser welding of boron steels for light-weight vehicle applications." Licentiate thesis, Högskolan Väst, Forskningsmiljön produktionsteknik(PTW), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-7263.
Full textRau, Mandy Kim [Verfasser], and Sotirios [Akademischer Betreuer] Bisdas. "Comparative Evaluation of Prognostic Value of Arterial Spin Labelling and Dynamic Susceptibility Contrast-Enhanced MR Imaging in High-Grade Gliomas / Mandy Kim Rau ; Betreuer: Sotirios Bisdas." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1198972548/34.
Full textLenzo, Jansen C. Lenzo. "Evaluation of the Effect of Tungsten and Boron Additions on the Microstructure and Solidification Cracking Susceptibility of Fe-Mn-C Filler Metals." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1470829433.
Full textBlanco-Vogt, Ángela [Verfasser], Jochen [Akademischer Betreuer] Schanze, Norbert [Akademischer Betreuer] Haala, and Elmar [Gutachter] Csaplovics. "Methodology for high resolution spatial analysis of the physical flood susceptibility of buildings in large river floodplains / Ángela Blanco-Vogt. Betreuer: Jochen Schanze ; Norbert Haala. Gutachter: Elmar Csaplovics." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://d-nb.info/1102086258/34.
Full textVallée, Maxime. "Design of an internet tool to assess variants of uncertain clinical significance in high-risk breast cancer genes BRCA1 and BRCA2." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10193.
Full textGermline mutations in major breast cancer susceptibility genes BRCA1 and BRCA2 are responsible for the disease for high-risk patients (patients with early onset and familial history of breast cancer). Around 15% of screened women for BRCA1 and BRCA2 mutations carry one clearly pathogenic mutation in one of those two genes. However, variants of uncertain clinical significance (VUS) are detected in 5% to 15% of tested patients. To assess clinical significance of VUS, the Breast cancer Information Core (BIC) has developed a Bayesian integrated model, based on observational data. Align-GVGD, an algorithm evaluating damage of missense substitutions based on the evolutionary history of the protein, is providing the prior probability of the model. However, whenever a silent substitution arise, it is firstly treated as neutral by the in silico assessment. Indeed, a mutation at the mRNA level can disrupt the splicing machinery by two main means: damaging wild-type splice sites, or creating exonic de novo splice sites. Our first goal is to be a central repository of already published variants, to re-analyze them using the unified integrated evaluation model. We would like to extract the most variants from the original published status of VUS to a more informative status, with associated clinical recommendations. Then we would like to extend the model to be able to evaluate more variants more precisely by adding the splicing damages assessment in the integrated evaluation. In the end, we will be able to provide these informations freely on Internet, via a widely use web interface, a Leiden Open Variation Database (LOVD)
Ghazanfari, Nader. "Effects Of Nb2o5 Addition On The Formation And Properties Of Bi-based Superconductors." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607468/index.pdf.
Full textCunha, Henrique Noguez da. "Avaliação da suscetibilidade à erosão da bacia hidrográfica do Alto Camaquã - RS." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/140931.
Full textThe excessive exploration of natural resources and the uncontrolled use of the territory, seeking a maximum profitability of the systems, has caused an intense concern about the environmental implications arising from lack of management of the natural areas. The environmental degradation processes are analyzed by the physical environment elements and the land covers and land uses included in the process, when data are integrated by geographical information systems and spatial models. In this sense, the objective of this study was to evaluate the susceptibility to erosion in the watershed of the Upper Camaquã river based on geotechnology, with emphasis in remote sensing and Geographic Information Systems. We evaluated the physical and anthropic aspects of the watershed according to the degree of susceptibility to erosion The Upper Camaquã watershed showed "stability/median susceptibility" with 3.111,5 square kilometers (60,7%) and lower representation of classes "Stable" with 138.4 km² ( 2.7%) “Moderately Stable " with 1358.4 square kilometers (26.5%) , " Moderately Susceptible" with 389.5 km² (7.6%) and "Susceptible" with 128.2 square kilometers (2.5%), however, two regions occurred when the physical and anthropogenic components were considered separately: (1) The western region with stable physical aspects, susceptible anthropogenic aspects and agricultural mechanization on flat to gently rolling terrains; (2) the eastern region with susceptible physical environment, stable land use, where terrain has largely, steep slopes and hilly terrains with rocky outcrop, unfit conditions to intensive agricultural activities.
Xu, Jinghao. "Alloy Design and Characterization of γ′ Strengthened Nickel-based Superalloys for Additive Manufacturing." Licentiate thesis, Linköpings universitet, Konstruktionsmaterial, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173042.
Full textAdditional funding agencies: Agora Materiae Graduate School for multidisiplinary PhD students at Linköping University, and Stiftelsen Axel Hultgren.
Fresneau, Brice. "Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant Investigating the Heterogeneity of Alkylating Agents' Efficacy and Toxicity Between Sexes: A Systematic Review and Meta-Analysis of Randomized Trials Comparing Cyclophosphamide and Ifosfamide (MAIAGE Study) Is Alpha-Fetoprotein Decline a Prognostic Factor of Childhood Non-Seminomatous Germ Cell Tumours? Results of the French TGM95 Study New Insight into Severe Ototoxicity after Childhood Cancer. Is there an Impact of Melphalan and Busulfan? A French Childhood Cancer Survivor Study A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated with High-Dose Methotrexate: Data from the OS2006/Sarcoma-09 Trial." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS034.
Full textTherapeutic advances in pediatric oncology have improved survival rates reaching over 80%. In order to increase cure rates and decrease complications and treatment sequelae, international collaborative efforts led to the development of therapeutic trials stratified on major prognostic factors including biological factors. However, treatment adaptation to individual patient characteristics remains marginal.In this thesis, our objective was to better understand how somatic (tumor-related) and constitutional (patient-related) characteristics could modify efficacy and toxicity of anticancer therapies used in pediatric oncology. Several works were performed: 1- Prognostic analysis of tumor markers: assessment of the alpha-foetoprotéine (AFP) decline prognostic value in childhood malignant germ cell tumors; 2- Prognostic analysis of constitutional factors: (i) assessment of the interaction between gender and type of alkylating agents on efficacy and acute toxicity; (ii) assessment of the efficacy and toxicity impact of genetic polymorphisms in patients with osteosarcoma treated with high-dose methotrexate; 3- Risk factors analysis of long-term toxicities: analysis of severe ototoxicity in the French Childhood Cancer Survivors Study (FCCSS)
Druaux, Fabrice. "Etude de la relation entre la cristallisation et l'évolution du magnétisme dans des couches minces désordonnées Ni-Ag riches en Ag." Rouen, 1986. http://www.theses.fr/1986ROUES039.
Full textBarilero, Gilles. "Etude de quelques proprietes magnetooptiques et magnetiques des semiconducteurs semimagnetiques zn : :(1-x)mn::(x)te et hg::(1-x)mn::(x)te." Paris 6, 1987. http://www.theses.fr/1987PA066084.
Full textGriveau, Jean-Christophe. "Etude de composés fermions lourds supraconducteurs sous hautes pressions : CECU2SI2 et UPD2AL3." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10252.
Full textRekik, Mahmoud. "Mesure et modélisation du comportement magnéto-mécanique dissipatif des matériaux ferromagnétiques à haute limite élastique sous chargement multiaxial." Thesis, Cachan, Ecole normale supérieure, 2014. http://www.theses.fr/2014DENS0019/document.
Full textThe research presented in this thesis is motivated by the design of rotors for high speed rotating machines. The increased power density of these devices requires a higher rotation speed, leading to higher levels of centrifugal forces and stress in the rotor. A first point is to ensure good mechanical strength of the materials. A second point is to take into account changes in the magnetic behavior (and ultimately torque) when they are subjected to a multiaxial stress state. The present study aims at exploring the influence of biaxial stress states on the magnetic behavior of the materials of the rotor. The challenge lies in the development of methods for the characterization of the magneto-mechanical dissipative uniaxial and multiaxial behavior of metal sheets developed by Aperam Alloy and used by Thales Avionics for their aeronautical applications (in FeCo-2V and non-oriented Fe-3%Si). Non conventional experiments are performed on cross-shaped samples in order to apply biaxial stress representative of the loadings experienced by rotors of rotating machines. These experiments are performed on a multiaxial testing machine, Astrée. Stress level is estimated thanks to digital image correlation and X-ray diffraction Both anhysteretic and dissipative magnetic responses to magneto-mechanical loadings have been recorded. On the other hand, a multi-scale multiaxial model describing the behavior of a RVE from the energy balance at the microscopic scale is presented. The approach is based on a comparison of the free energy of each domain. A probabilistic comparison is made to determine the volume fraction of domains used as internal variables. Different strategies for modeling the static dissipation are discussed. Then we present the chosen magneto-elastic approach, improving the description of the effect of stress on ferromagnetic materials behavior
Opagiste, Christine. "Synthèse et étude des propriétés magnétiques des composés supraconducteurs surdopés à base de thallium." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10097.
Full textBillon, Bertrand. "Etude microcalorimétrique et magnétique du diagramme de phase des composés YBa2Cu3O(7-(delta)) et HgBa2CuO(4+(delta)." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10132.
Full textGautier, Eric. "Etude des propriétés structurales et physiques de la famille d'oxycarbonates supraconducteurs (Cu,C)Ba2Ca(n-1)CunOy." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10281.
Full textCheaito, Bassam. "Contribution à l'étude de la supraconductivité anormale du composé EuMo6S8." Grenoble 1, 1986. http://www.theses.fr/1986GRE10100.
Full textAlmasri, Hanine. "Toxicologie des mélanges de pesticides chez des abeilles exposées à un agent pathogène : action combinée de l'agent pathogène Nosema ceranae, de l'insecticide imidaclopride, du fongicide difénoconazole et de l'herbicide glyphosate Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees Toxicity of the pesticides imidacloprid, difenoconazole and glyphosate alone and in binary and ternary mixtures to winter honey bees: effects on survival and antioxidative defenses Toxicological status changes the susceptibility of the honey bee Apis mellifera to a single fungicidal spray application Physiological effects of the interaction between Nosema ceranae and sequential and overlapping exposure to glyphosate and difenoconazole in the honey bee Apis mellifera." Thesis, Avignon, 2020. http://www.theses.fr/2020AVIG0722.
Full textCurrent scientific findings suggest a decline in the diversity and abundance of insects, including the honey bee Apis mellifera. The latter are facing high colony losses in several regions of the world such as Western Europe and the United States. Numerous studies suggest that the origin of bee colony decline is multi-causal and identify pesticides and pathogens as the main contributors to this decline. Co-exposure of honey bees to multiple pesticides and infection by multiple pathogens are common phenomena. However, research on the effects of pesticide mixtures has not been extensively developed. Thus, the thesis work has focused on determining the toxicity of pesticide mixtures, applied at environmental exposure levels, in the presence of pathogens. The choice was made to study the interactions between a neonicotinoid insecticide, imidacloprid, an azole fungicide, difenoconazole, and a herbicide, glyphosate, in the presence of the pathogen Nosema ceranae. The results of the different studies, carried out during this thesis, reveal the complexity of the studies on pesticide mixtures. The work allowed us to notice that the effects of a pesticide mixture can vary according to the concentrations of the pesticides constituting the mixture. The increase of the number of substances and the level of exposure does not necessarily induce an increase of the toxicity of the mixture. Furthermore, the effects of the mixture may vary depending on the sequence of exposure to the different pesticides and the health status of the honey bees. Pesticide mixtures affect the physiological state of individuals as a result of a systemic response related to disturbances of general mechanisms such as oxidative stress. However, these three pesticides, alone and in mixtures, have no effect on the installation of the intestinal microbiota at environmental exposure levels
Thomas, Amandine. "Hypoxie intermittente et homéostasie glucidique : étude des mécanismes d'action cellulaire A hybrid model to study pathological mutations of the human ADP/ATP carriers Visceral white fat remodeling contributes to intermittent hypoxia-induced atherogenesis The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system The Impact of Sleep Disorders on Glucose Metabolism: Endocrine and Molecular Mechanisms Endoplasmic reticulum stress as a novel inducer of hypoxia inducible factor-1 activity: its role in the susceptibility to myocardial ischemia-reperfusion induced by chronic intermittent hypoxia Chronic intermittent hypoxia improves whole-body glucose tolerance by activating skeletal muscle AMP-activated protein kinase in mice Prolyl-4-hydroxylase 1 (PHD1) deficiency impairs whole-body glucose tolerance and insulin sensitivity in mice but does not worsen high-fat diet-induced metabolic dysfunctions Specific transcriptomic signature in response to intermittent hypoxia exposure in liver and fat tissue." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV044.
Full textIntermittent hypoxia (IH), induced by sleep apnea, leads to alterations in insulin sensitivity and glucose homeostasis but the mechanisms involved remains poorly understood. The objective of this work was to study the effects and the underlying mechanisms of chronic exposure to IH on glucose homeostasis. IH induces both systemic and tissue-specific insulin resistance , as well as improved glucose tolerance associated with an activation of muscle AMPK. IH also causes a change in the pattern of gene expression in liver and adipose tissue and an increased risk of vascular pathologies such as atherosclerosis development. Finally, the deletion of PHD1, a regulatory protein of HIF-1, leads to insulin resistance associated with hepatic steatosis, making HIF-1 a possible target involved in the metabolic changes induced by IH