Journal articles: 'High integration'

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York, Ashley. "High-order integration." Nature Reviews Microbiology 15, no. 3 (January 23, 2017): 133. http://dx.doi.org/10.1038/nrmicro.2017.3.

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ZHEN, YI, LIU ZHAO, and ZHANYING YANG. "INTEGRATING SUPER-LIOUVILLE SYSTEM WITHOUT INTEGRATION." Modern Physics Letters A 15, no. 09 (March 21, 2000): 617–28. http://dx.doi.org/10.1142/s0217732300000621.

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Explicit solutions of super-Liouville equation are obtained by the use of a super-extension of the so-called Drinfeld–Sokolov construction. Such solutions can be proved to be local and super-periodic using earlier results of Toppan on exchange algebras based on super-Drinfeld–Sokolov linear systems and of Babelon et al. on the proof of locality and periodicity of ordinary Toda field theories.

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Sukhi, Y., Y. Jeyashree, S. Anita, A. Jenifer, and A. Fayaz Ahamed. "High Step Up Converter with Transformerless Inverter for Grid Integration." Indian Journal Of Science And Technology 15, no. 34 (September 13, 2022): 1655–65. http://dx.doi.org/10.17485/ijst/v15i34.1131.

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Gao, Xin, and Raymond J. Carroll. "Data integration with high dimensionality." Biometrika 104, no. 2 (May 9, 2017): 251–72. http://dx.doi.org/10.1093/biomet/asx023.

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Summary We consider situations where the data consist of a number of responses for each individual, which may include a mix of discrete and continuous variables. The data also include a class of predictors, where the same predictor may have different physical measurements across different experiments depending on how the predictor is measured. The goal is to select which predictors affect any of the responses, where the number of such informative predictors tends to infinity as the sample size increases. There are marginal likelihoods for each experiment; we specify a pseudolikelihood combining the marginal likelihoods, and propose a pseudolikelihood information criterion. Under regularity conditions, we establish selection consistency for this criterion with unbounded true model size. The proposed method includes a Bayesian information criterion with appropriate penalty term as a special case. Simulations indicate that data integration can dramatically improve upon using only one data source.

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Yant, Stephen R., Xiaolin Wu, Yong Huang, Brian Garrison, Shawn M. Burgess, and Mark A. Kay. "High-Resolution Genome-Wide Mapping of Transposon Integration in Mammals." Molecular and Cellular Biology 25, no. 6 (March 15, 2005): 2085–94. http://dx.doi.org/10.1128/mcb.25.6.2085-2094.2005.

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ABSTRACT The Sleeping Beauty (SB) transposon is an emerging tool for transgenesis, gene discovery, and therapeutic gene delivery in mammals. Here we studied 1,336 SB insertions in primary and cultured mammalian cells in order to better understand its target site preferences. We report that, although widely distributed, SB integration recurrently targets certain genomic regions and shows a small but significant bias toward genes and their upstream regulatory sequences. Compared to those of most integrating viruses, however, the regional preferences associated with SB-mediated integration were much less pronounced and were not significantly influenced by transcriptional activity. Insertions were also distinctly nonrandom with respect to intergenic sequences, including a strong bias toward microsatellite repeats, which are predominantly enriched in noncoding DNA. Although we detected a consensus sequence consistent with a twofold dyad symmetry at the target site, the most widely used sites did not match this consensus. In conjunction with an observed SB integration preference for bent DNA, these results suggest that physical properties may be the major determining factor in SB target site selection. These findings provide basic insights into the transposition process and reveal important distinctions between transposon- and virus-based integrating vectors.

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Kolchugina, M. "International Integration in High Education Sphere." World Economy and International Relations, no. 11 (2005): 55–64. http://dx.doi.org/10.20542/0131-2227-2005-11-55-64.

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Maerkl, Sebastian J. "Integration column: Microfluidic high-throughput screening." Integr. Biol. 1, no. 1 (2009): 19–29. http://dx.doi.org/10.1039/b819762h.

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Havemann, R. H., and J. A. Hutchby. "High-performance interconnects: an integration overview." Proceedings of the IEEE 89, no. 5 (May 2001): 586–601. http://dx.doi.org/10.1109/5.929646.

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Takhtamyshev, George, Bart Vandewoestyne, and Ronald Cools. "Quasi-random integration in high dimensions." Mathematics and Computers in Simulation 73, no. 5 (January 2007): 309–19. http://dx.doi.org/10.1016/j.matcom.2006.04.001.

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Roudaia, E., P. J. Bennett, and A. B. Sekuler. "High-contrast contour integration and aging." Journal of Vision 8, no. 6 (March 26, 2010): 418. http://dx.doi.org/10.1167/8.6.418.

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Schlier, Ch, and A. Seiter. "High-order symplectic integration: an assessment." Computer Physics Communications 130, no. 1-2 (July 2000): 176–89. http://dx.doi.org/10.1016/s0010-4655(00)00011-4.

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Tyler, Matthew, and John J. Naughton. "High Volt Mixed Signal Integration Challenges." ECS Transactions 11, no. 6 (December 19, 2019): 461–66. http://dx.doi.org/10.1149/1.2778402.

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Na, Yoon-Soo, Tae-Young Lim, Jin-Ho Kim, Hyo-Soon Shin, Jong-Hee Hwang, and Yong-Soo Cho. "Low k Materials for High Frequency High Integration Modules." Journal of the Korean Ceramic Society 46, no. 4 (July 31, 2009): 413–18. http://dx.doi.org/10.4191/kcers.2009.46.4.413.

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Aziz, Bakhtiar Qader, and Peshawa Mohammad Ali. "Karst cavity detection in carbonate rocks by integration of high resolution geophysical methods." Journal of Zankoy Sulaimani - Part A 15, no. 1 (December 17, 2012): 159–71. http://dx.doi.org/10.17656/jzs.10240.

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Brick Larkin, Gabriella, and Daniel D. Kurylo. "Perceptual Grouping and High-Order Cognitive Ability." Journal of Individual Differences 34, no. 3 (August 1, 2013): 153–58. http://dx.doi.org/10.1027/1614-0001/a000110.

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High-order cognitive functions require the integration of information across functionally related modules. This relationship suggests that cognitive ability is related to the efficiency and processing speed of basic integrative function. In order to examine individual differences for this relationship, we compared standardized tests of intelligence to visual perceptual grouping abilities, which represents a basic process of integration. Sixty participants discriminated perceived grouping of dot patterns based upon similarity in luminance. Psychophysical measurements were made of the functional limits and processing speed of grouping. We assessed cognitive abilities with the Wechsler Abbreviated Scale of Intelligence (WASI) and found that measures of grouping efficiency as well as speed varied considerably across subjects, indicating substantial individual differences at this relatively early level of visual processing. Faster grouping speed was associated with higher scores on all WASI subtests, whereas grouping ability, when not restricted by time, was associated only with the performance IQ components. These results demonstrate an association between a basic integrative function, in which cognitive and motoric factors were minimized, with measures of high-order cognition, which include both verbal and spatial cognitive components.

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Wu, Cen, Fei Zhou, Jie Ren, Xiaoxi Li, Yu Jiang, and Shuangge Ma. "A Selective Review of Multi-Level Omics Data Integration Using Variable Selection." High-Throughput 8, no. 1 (January 18, 2019): 4. http://dx.doi.org/10.3390/ht8010004.

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High-throughput technologies have been used to generate a large amount of omics data. In the past, single-level analysis has been extensively conducted where the omics measurements at different levels, including mRNA, microRNA, CNV and DNA methylation, are analyzed separately. As the molecular complexity of disease etiology exists at all different levels, integrative analysis offers an effective way to borrow strength across multi-level omics data and can be more powerful than single level analysis. In this article, we focus on reviewing existing multi-omics integration studies by paying special attention to variable selection methods. We first summarize published reviews on integrating multi-level omics data. Next, after a brief overview on variable selection methods, we review existing supervised, semi-supervised and unsupervised integrative analyses within parallel and hierarchical integration studies, respectively. The strength and limitations of the methods are discussed in detail. No existing integration method can dominate the rest. The computation aspects are also investigated. The review concludes with possible limitations and future directions for multi-level omics data integration.

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Bedwell, Gregory J., Sooin Jang, Wen Li, Parmit K. Singh, and Alan N. Engelman. "rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo." Nucleic Acids Research 49, no. 13 (June 24, 2021): 7330–46. http://dx.doi.org/10.1093/nar/gkab514.

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Abstract HIV-1 integration favors recurrent integration gene (RIG) targets and genic proviruses can confer cell survival in vivo. However, the relationship between initial RIG integrants and how these evolve in patients over time are unknown. To address these shortcomings, we built phenomenological models of random integration in silico, which were used to identify 3718 RIGs as well as 2150 recurrent avoided genes from 1.7 million integration sites across 10 in vitro datasets. Despite RIGs comprising only 13% of human genes, they harbored 70% of genic HIV-1 integrations across in vitro and patient-derived datasets. Although previously reported to associate with super-enhancers, RIGs tracked more strongly with speckle-associated domains. While depletion of the integrase cofactor LEDGF/p75 significantly reduced recurrent HIV-1 integration in vitro, LEDGF/p75 primarily occupied non-speckle-associated regions of chromatin, suggesting a previously unappreciated dynamic aspect of LEDGF/p75 functionality in HIV-1 integration targeting. Finally, we identified only six genes from patient samples—BACH2, STAT5B, MKL1, MKL2, IL2RB and MDC1—that displayed enriched integration targeting frequencies and harbored proviruses that likely contributed to cell survival. Thus, despite the known preference of HIV-1 to target cancer-related genes for integration, we conclude that genic proviruses play a limited role to directly affect cell proliferation in vivo.

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Wang, Zehua, Xiqian Ye, Yuenan Zhou, Xiaotong Wu, Rongmin Hu, Jiachen Zhu, Ting Chen, et al. "Bracoviruses recruit host integrases for their integration into caterpillar’s genome." PLOS Genetics 17, no. 9 (September 7, 2021): e1009751. http://dx.doi.org/10.1371/journal.pgen.1009751.

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Some DNA viruses infect host animals usually by integrating their DNAs into the host genome. However, the mechanisms for integration remain largely unknown. Here, we find that Cotesia vestalis bracovirus (CvBV), a polydnavirus of the parasitic wasp C. vestalis (Haliday), integrates its DNA circles into host Plutella xylostella (L.) genome by two distinct strategies, conservatively and randomly, through high-throughput sequencing analysis. We confirmed that the conservatively integrating circles contain an essential “8+5” nucleotides motif which is required for integration. Then we find CvBV circles are integrated into the caterpillar’s genome in three temporal patterns, the early, mid and late stage-integration. We further identify that three CvBV-encoded integrases are responsible for some, but not all of the virus circle integrations, indeed they mainly participate in the processes of early stage-integration. Strikingly, we find two P. xylostella integrases (PxIN1 and PxIN2) are highly induced upon wasp parasitism, and PxIN1 is crucial for integration of some other early-integrated CvBV circles, such as CvBV_04, CvBV_12 and CvBV_24, while PxIN2 is important for integration of a late-integrated CvBV circle, CvBV_21. Our data uncover a novel mechanism in which CvBV integrates into the infected host genome, not only by utilizing its own integrases, but also by recruiting host enzymes. These findings will strongly deepen our understanding of how bracoviruses regulate and integrate into their hosts.

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Balla, A., M. Beretta, P. Branchini, P. Ciambrone, G. Corradi, E. De Lucia, P. De Simone, et al. "A 32 channels charge integrating ADC based on digital signal integration." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 562, no. 1 (June 2006): 141–45. http://dx.doi.org/10.1016/j.nima.2006.03.011.

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Fujiyoshi, Motohiro, Yutaka Nonomura, and Hidemi Senda. "High-sensitivity Leak-testing Method with High-Resolution Integration Technique." IEEJ Transactions on Sensors and Micromachines 132, no. 8 (2012): 240–45. http://dx.doi.org/10.1541/ieejsmas.132.240.

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Rajaby, Ramesh, Yi Zhou, Yifan Meng, Xi Zeng, Guoliang Li, Peng Wu, and Wing-Kin Sung. "SurVirus: a repeat-aware virus integration caller." Nucleic Acids Research 49, no. 6 (January 14, 2021): e33-e33. http://dx.doi.org/10.1093/nar/gkaa1237.

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Abstract A significant portion of human cancers are due to viruses integrating into human genomes. Therefore, accurately predicting virus integrations can help uncover the mechanisms that lead to many devastating diseases. Virus integrations can be called by analysing second generation high-throughput sequencing datasets. Unfortunately, existing methods fail to report a significant portion of integrations, while predicting a large number of false positives. We observe that the inaccuracy is caused by incorrect alignment of reads in repetitive regions. False alignments create false positives, while missing alignments create false negatives. This paper proposes SurVirus, an improved virus integration caller that corrects the alignment of reads which are crucial for the discovery of integrations. We use publicly available datasets to show that existing methods predict hundreds of thousands of false positives; SurVirus, on the other hand, is significantly more precise while it also detects many novel integrations previously missed by other tools, most of which are in repetitive regions. We validate a subset of these novel integrations, and find that the majority are correct. Using SurVirus, we find that HPV and HBV integrations are enriched in LINE and Satellite regions which had been overlooked, as well as discover recurrent HBV and HPV breakpoints in human genome-virus fusion transcripts.

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Hajduk, Philip J., and David J. Burns. "Integration of NMR and High-Throughput Screening." Combinatorial Chemistry & High Throughput Screening 5, no. 8 (December 1, 2002): 613–21. http://dx.doi.org/10.2174/1386207023329996.

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Kazashi, Y., F. Y. Kuo, and I. H. Sloan. "Derandomised lattice rules for high dimensional integration." ANZIAM Journal 60 (November 16, 2019): C247—C260. http://dx.doi.org/10.21914/anziamj.v60i0.14110.

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We seek shifted lattice rules that are good for high dimensional integration over the unit cube in the setting of an unanchored weighted Sobolev space of functions with square-integrable mixed first derivatives. Many existing studies rely on random shifting of the lattice, whereas here we work with lattice rules with a deterministic shift. Specifically, we consider 'half-shifted' rules in which each component of the shift is an odd multiple of \(1/(2N)\) where \(N\) is the number of points in the lattice. By applying the principle that there is always at least one choice as good as the average, we show that for a given generating vector there exists a half-shifted rule whose squared worst-case error differs from the shift-averaged squared worst-case error by a term of only order \({1/N^2}\). We carry out numerical experiments where the generating vector is chosen component-by-component (CBC), as for randomly shifted lattices, and where the shift is chosen by a new `CBC for shift' algorithm. The numerical results are encouraging. References J. Dick, F. Y. Kuo, and I. H. Sloan. High-dimensional integration: The quasi-Monte Carlo way. Acta Numer., 22:133–288, 2013. doi:10.1017/S0962492913000044. J. Dick, D. Nuyens, and F. Pillichshammer. Lattice rules for nonperiodic smooth integrands. Numer. Math., 126(2):259–291, 2014. doi:10.1007/s00211-013-0566-0. T. Goda, K. Suzuki, and T. Yoshiki. Lattice rules in non-periodic subspaces of sobolev spaces. Numer. Math., 141(2):399–427, 2019. doi:10.1007/s00211-018-1003-1. F. Y. Kuo. Lattice rule generating vectors. URL http://web.maths.unsw.edu.au/ fkuo/lattice/index.html. D. Nuyens and R. Cools. Fast algorithms for component-by-component construction of rank-1 lattice rules in shift-invariant reproducing kernel Hilbert spaces. Math. Comput., 75:903–920, 2006. doi:10.1090/S0025-5718-06-01785-6. I. H. Sloan and S. Joe. Lattice methods for multiple integration. Oxford Science Publications. Clarendon Press and Oxford University Press, 1994. URL https://global.oup.com/academic/product/lattice-methods-for-multiple-integration-9780198534723. I. H. Sloan and H. Wozniakowski. When are quasi-Monte Carlo algorithms efficient for high dimensional integrals? J. Complex., 14(1):1–33, 1998. doi:10.1006/jcom.1997.0463. I. H. Sloan, F. Y. Kuo, and S. Joe. On the step-by-step construction of quasi-Monte Carlo integration rules that achieve strong tractability error bounds in weighted Sobolev spaces. Math. Comput., 71:1609–1641, 2002. doi:10.1090/S0025-5718-02-01420-5.

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Xiang, Chao, Warren Jin, Duanni Huang, Minh A. Tran, Joel Guo, Yating Wan, Weiqiang Xie, et al. "High-Performance Silicon Photonics Using Heterogeneous Integration." IEEE Journal of Selected Topics in Quantum Electronics 28, no. 3 (May 2022): 1–15. http://dx.doi.org/10.1109/jstqe.2021.3126124.

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Su, Han. "A high-integration on-chip reconfigurable monopole." IEICE Electronics Express 19, no. 2 (January 25, 2022): 20210462. http://dx.doi.org/10.1587/elex.18.20210462.

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Peng, Tony Chia-Yu, John H. Lau, Cheng-Ta Ko, Paul Lee, Eagle Lin, Kai-Ming Yang, Bruce Puru Lin, et al. "High-Density Hybrid Substrate for Heterogeneous Integration." IEEE Transactions on Components, Packaging and Manufacturing Technology 12, no. 3 (March 2022): 469–78. http://dx.doi.org/10.1109/tcpmt.2022.3151848.

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Stohlmann, Micah. "STEM Integration for High School Mathematics Teachers." Journal of Research in STEM Education 6, no. 1 (July 27, 2020): 52–63. http://dx.doi.org/10.51355/jstem.2020.71.

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The discipline of mathematics in science, technology, engineering, and mathematics (STEM) integration has not yet been consistently connected in a clear way for a large amount of high school mathematics teacher to implement STEM integration well. In response to this I have proposed a focus on integrated steM education; the integration of STEM subjects with an explicit focus on mathematics. There are benefits to integrated steM education in a mathematics classroom including increased motivation, interest, and achievement for students. Integrated steM integration can also prepare students with the needed proficiencies and knowledge bases to be productive and impactful members of society. This article discusses three methods that high school mathematics teachers can utilize for integrated steM education. By focusing on open-ended problems through engineering design challenges, mathematical modeling, and mathematics integrated with technology high school students are more likely to see mathematics as meaningful and valuable. Examples of each method are discussed along with common instructional elements among the methods.

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Razak, F. N. A., M. S. A. Talip, M. F. M. Yakub, A. S. M. Khairudin, T. F. T. M. N. Izam, and F. H. K. Zaman. "High speed numerical integration algorithm using FPGA." Journal of Fundamental and Applied Sciences 9, no. 4S (January 23, 2018): 131. http://dx.doi.org/10.4314/jfas.v9i4s.7.

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Hou, Zhao Ming, Jia Wei Yao, and Chun Yan Zhao. "Functional Integration of Contemporary High-Rise Buildings." Applied Mechanics and Materials 174-177 (May 2012): 1763–66. http://dx.doi.org/10.4028/www.scientific.net/amm.174-177.1763.

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Due to the continuous upgrading technology of high-rise buildings, function expansion of high-rise buildings has unlimited possibilities, in the specific performance of function system’s optimization and function model’s integration. Function expansion make high-rise buildings’ image become various with a variety of features, internal use space become more efficient, convenient, thus for mankind to create a more comfortable space.

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Ray, Navamita, Duo Wang, Xiangmin Jiao, and James Glimm. "High-Order Numerical Integration over Discrete Surfaces." SIAM Journal on Numerical Analysis 50, no. 6 (January 2012): 3061–83. http://dx.doi.org/10.1137/110857404.

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Bajorath, Jürgen. "Integration of virtual and high-throughput screening." Nature Reviews Drug Discovery 1, no. 11 (November 2002): 882–94. http://dx.doi.org/10.1038/nrd941.

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Shefketi, Batije, and Mentor Hamiti. "Challenges of Facebook Integration in High Education." SEEU Review 14, no. 1 (July 1, 2019): 207–25. http://dx.doi.org/10.2478/seeur-2019-0012.

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Abstract Currently, the Internet has become a part of the everyday life of human beings. The way of communication between people has changed and social networks are dominating in the lives of everyone. One of the most used social networks is Facebook, but besides that it is used for communication and entertainment, Facebook can also be used for learning. Therefore, the main issue of this paper is the use of Facebook for educational approaches by students and teachers. Case studies are the challenges of integration of Facebook in High Education in the municipality of Kumanovo in the Republic of North Macedonia in 2016. Special emphasis is devoted in usage of Facebook in schools as the main questions were whether students use Facebook to ask for help for assignments or any material, and do teachers use Facebook to post assignments and to communicate with students. To understand this, there are conducted two questionnaires, one to students and one to teachers and interviews with school principals, and finally responses of people who participated have been analyzed. The result is that by joining Facebook in education, students are more motivated to learn, Facebook helps students to learn by sharing knowledge with each other and by using Facebook at school, teachers will find it easier to inform students.

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ROSS, JOHN F. L. "High-speed Rail: Catalyst for European Integration?" JCMS: Journal of Common Market Studies 32, no. 2 (June 1994): 191–214. http://dx.doi.org/10.1111/j.1468-5965.1994.tb00493.x.

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Erickson, Amy K. "Clinical integration leads to high-value care." Pharmacy Today 19, no. 12 (December 2013): 8. http://dx.doi.org/10.1016/s1042-0991(15)31049-5.

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Bailey, D. H., and J. M. Borwein. "High-precision numerical integration: Progress and challenges." Journal of Symbolic Computation 46, no. 7 (July 2011): 741–54. http://dx.doi.org/10.1016/j.jsc.2010.08.010.

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Liu, Liu, Zhanghua Han, and Sailing He. "Novel surface plasmon waveguide for high integration." Optics Express 13, no. 17 (2005): 6645. http://dx.doi.org/10.1364/opex.13.006645.

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Fukushima, K., R. M. O'Donnell, K. Fujiwara, H. Kai, E. Okunishi, M. Kawasaki, M. Kersker, and M. Naruse. "Computer Controlled High-Throughput Integration System: FasTEM." Microscopy and Microanalysis 6, S2 (August 2000): 1144–45. http://dx.doi.org/10.1017/s1431927600038216.

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IntroductionFor the nano-area analysis of materials, it is necessary to evaluate all data obtained by HRTEM, EDS, EELS, and/or Energy Filter. Up till now, each analytical/imaging instrument required its original computer control system. Thus, the total operational environment for the nano-area analysis was not convenient for us. Recent progress of computer technology provides the ability to build a high performance environment for seamless operation by Client/Server design.We have developed computer controlled high-throughput integration system based on PC, called FasTEM system, having seamless integration function and real-time remote control function of all instruments related to nano-area analysis. The FasTEM system is composed of Windows NT based Server PC System that is connected to the target TEM via RS232C for integrated operation, and Client PC SYSTEM connected to the Server PC via TCP/IP for remote operation (Fig.l).Seamless Integration FunctionAll user interfaces of the analytical/imaging instruments, such as HRTEM, STEM BF/DF, EDS, PEELS and GIF can be seamlessly integrated into the Server PC.

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Edwards High Vacuum. "Integration of Temescal into Edwards high vacuum." Vacuum 38, no. 8-10 (January 1988): 963. http://dx.doi.org/10.1016/0042-207x(88)90552-0.

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Novotny, V. J. "Mechanical integration of high recording density drives." IEEE Transactions on Magnetics 32, no. 3 (May 1996): 1826–31. http://dx.doi.org/10.1109/20.492872.

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Badila, Marian, Gheorghe Brezeanu, Florin Mitu, Gheorghe Dilimot, and Cecilia Codreanu. "Integration technique for high frequency bipolar circuits." Microelectronics Journal 29, no. 10 (October 1998): 721–25. http://dx.doi.org/10.1016/s0026-2692(98)00039-1.

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Rudzewski, Stephen. "Lightweight Roof Module With High Functional Integration." ATZ worldwide 116, no. 11 (October 2014): 18–23. http://dx.doi.org/10.1007/s38311-014-0237-5.

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Palmer, P. L., S. J. Aarseth, S. Mikkola, and Yoshi Hashida. "High Precision Integration Methods for Orbit Propagation." Journal of the Astronautical Sciences 46, no. 4 (December 1998): 329–42. http://dx.doi.org/10.1007/bf03546385.

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Chasserio, N., S. Guillemet-Fritsch, T. Lebey, and S. Dagdag. "Ceramic Substrates for High-temperature Electronic Integration." Journal of Electronic Materials 38, no. 1 (October 7, 2008): 164–74. http://dx.doi.org/10.1007/s11664-008-0571-8.

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Möller, Peter W. "High-order hierarchicalA- andL-stable integration methods." International Journal for Numerical Methods in Engineering 36, no. 15 (August 15, 1993): 2607–24. http://dx.doi.org/10.1002/nme.1620361507.

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Li, Hui, Ruifen Zhang, Yupin Cai, Yuan Li, Xuemei Cheng, Baoli Zhu, Yi Yang, and Yang Xiang. "Determination of Integrated HPV58 Sequences in Cervical Lesions." International Journal of Gynecologic Cancer 22, no. 7 (September 2012): 1234–37. http://dx.doi.org/10.1097/igc.0b013e31825d4716.

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Integration of high-risk HPV in host genome is an important event in cervical cancer development. This study was aimed to analyze the integration of HPV58, a high-risk type that is prevalent in cervical lesions from southeastern Asia. Detection of integrated papillomavirus sequences by ligation-mediated polymerase chain reaction followed by DNA sequencing revealed 8 integrations in 5 samples, and virus integration was found present in 2 samples with early lesion. Sequence analysis of the viral-cellular junctions showed that E1 disruption in virus genome was an early and common event during HPV58 infection. In 6 integrations, DNA fragments of HPV58 genome integrated into the repetitive element sequences of host genome.

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Yuan, Zhaoyang, Qingxin Yang, Xian Zhang, Xianjie Ma, Zhixin Chen, Ming Xue, and Pengcheng Zhang. "High-Order Compensation Topology Integration for High-Tolerant Wireless Power Transfer." Energies 16, no. 2 (January 5, 2023): 638. http://dx.doi.org/10.3390/en16020638.

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Wireless power transfer (WPT) has been a promising way to transfer power wirelessly over certain distances through the mutual inductance (MI) of the magnetically coupled transmitter and receiver coils, providing significant benefits of convenience, safety, and feasibility to special occasions. The stable output and efficiency cannot be maintained due to the load variation and the inevitable misalignment between the magnetic couplers. High-order compensation topologies that are highly flexible in design due to more compensation elements are essential for the WPT to suppress the load variation and misalignment effects. However, due to core loss and thermal management, high-power-level and high-frequency inductor design have always been challenging for WPT systems. Space occupation and cost are other aspects to be considered for inductor design. Thus integrating these additional bulky inductors into the main coils has been a critical trial. As a result, the compensation topologies’ original input and output profiles will change or even disappear. This paper reviews the existing high-order compensation topologies and their integration principles and implementation for the WPT to obtain high misalignment tolerance. The design objectives and challenges of the integrated compensation topology in terms of misalignment tolerance capability are discussed. The relevant control systems to cope with coil misalignment and load variations are investigated. Challenges and future development of the high-tolerant WPT are discussed.

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López de Maturana, Evangelina, Lola Alonso, Pablo Alarcón, Isabel Adoración Martín-Antoniano, Silvia Pineda, Lucas Piorno, M. Luz Calle, and Núria Malats. "Challenges in the Integration of Omics and Non-Omics Data." Genes 10, no. 3 (March 20, 2019): 238. http://dx.doi.org/10.3390/genes10030238.

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Omics data integration is already a reality. However, few omics-based algorithms show enough predictive ability to be implemented into clinics or public health domains. Clinical/epidemiological data tend to explain most of the variation of health-related traits, and its joint modeling with omics data is crucial to increase the algorithm’s predictive ability. Only a small number of published studies performed a “real” integration of omics and non-omics (OnO) data, mainly to predict cancer outcomes. Challenges in OnO data integration regard the nature and heterogeneity of non-omics data, the possibility of integrating large-scale non-omics data with high-throughput omics data, the relationship between OnO data (i.e., ascertainment bias), the presence of interactions, the fairness of the models, and the presence of subphenotypes. These challenges demand the development and application of new analysis strategies to integrate OnO data. In this contribution we discuss different attempts of OnO data integration in clinical and epidemiological studies. Most of the reviewed papers considered only one type of omics data set, mainly RNA expression data. All selected papers incorporated non-omics data in a low-dimensionality fashion. The integrative strategies used in the identified papers adopted three modeling methods: Independent, conditional, and joint modeling. This review presents, discusses, and proposes integrative analytical strategies towards OnO data integration.

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Cattoglio, Claudia, Danilo Pellin, Ermanno Rizzi, Giulietta Maruggi, Giorgio Corti, Francesca Miselli, Daniela Sartori, et al. "High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors." Blood 116, no. 25 (December 16, 2010): 5507–17. http://dx.doi.org/10.1182/blood-2010-05-283523.

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Abstract Integration of retroviral vectors in the human genome follows nonrandom patterns that favor insertional deregulation of gene expression and increase the risk of their use in clinical gene therapy. The molecular basis of retroviral target site selection is still poorly understood. We used deep sequencing technology to build genomewide, high-definition maps of > 60 000 integration sites of Moloney murine leukemia virus (MLV)– and HIV-based retroviral vectors in the genome of human CD34+ multipotent hematopoietic progenitor cells (HPCs) and used gene expression profiling, chromatin immunoprecipitation, and bioinformatics to associate integration to genetic and epigenetic features of the HPC genome. Clusters of recurrent MLV integrations identify regulatory elements (alternative promoters, enhancers, evolutionarily conserved noncoding regions) within or around protein-coding genes and microRNAs with crucial functions in HPC growth and differentiation, bearing epigenetic marks of active or poised transcription (H3K4me1, H3K4me2, H3K4me3, H3K9Ac, Pol II) and specialized chromatin configurations (H2A.Z). Overall, we mapped 3500 high-frequency integration clusters, which represent a new resource for the identification of transcriptionally active regulatory elements. High-definition MLV integration maps provide a rational basis for predicting genotoxic risks in gene therapy and a new tool for genomewide identification of promoters and regulatory elements controlling hematopoietic stem and progenitor cell functions.

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Huang, Weihong, Haoxuan Jiao, Qiuyue Huang, Jiaona Zhang, and Min Zhang. "Ultra-high drivability, high-mobility, low-voltage and high-integration intrinsically stretchable transistors." Nanoscale 12, no. 46 (2020): 23546–55. http://dx.doi.org/10.1039/d0nr05486k.

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Realizing intrinsically stretchable transistors with high current drivability, high mobility, small feature size, low power and the potential for mass production is essential for advancing stretchable electronics a critical step forward.

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Kurashige, H., T. Taniguchi, and Y. Yoribayashi. "A high-resolution and high-stability charge-integration ADC for high-rate experiments." IEEE Transactions on Nuclear Science 35, no. 3 (June 1988): 1018–21. http://dx.doi.org/10.1109/23.3695.

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Journal articles on the topic 'High integration'

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