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1

Salim, Ali, and Matthew Martin. "High-frequency percussive ventilation." Critical Care Medicine 33, Supplement (March 2005): S241—S245. http://dx.doi.org/10.1097/01.ccm.0000155921.32083.ce.

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2

Martin, Matthew J., and Ali Salim. "High-Frequency Percussive Ventilation." Critical Care Medicine 33, no. 9 (September 2005): 2155–56. http://dx.doi.org/10.1097/01.ccm.0000179011.89720.c2.

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3

Lucangelo, Umberto, Vittorio Antonaglia, Antonino Gullo, and Walter A. Zin. "High-Frequency Percussive Ventilation." Critical Care Medicine 33, no. 9 (September 2005): 2155. http://dx.doi.org/10.1097/01.ccm.0000179024.47543.fe.

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4

Boscolo, Annalisa, Arianna Peralta, Fabio Baratto, Sandra Rossi, and Carlo Ori. "High-Frequency Percussive Ventilation." A & A Case Reports 4, no. 7 (April 2015): 79–84. http://dx.doi.org/10.1213/xaa.0000000000000131.

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5

Allan, Patrick F., Erik C. Osborn, Kevin K. Chung, and Sandra M. Wanek. "High-Frequency Percussive Ventilation Revisited." Journal of Burn Care & Research 31, no. 4 (July 2010): 510–20. http://dx.doi.org/10.1097/bcr.0b013e3181e4d605.

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6

Kunugiyama, Sujen K., and Christine S. Schulman. "High-Frequency Percussive Ventilation Using the VDR-4 Ventilator." AACN Advanced Critical Care 23, no. 4 (October 1, 2012): 370–80. http://dx.doi.org/10.4037/nci.0b013e31826e9031.

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High-frequency percussive ventilation (HFPV) has been used for patients with severe respiratory compromise refractory to conventional mechanical ventilation. It frequently results in equivalent or improved oxygenation and ventilation at lower peak pressures than conventional ventilation, thus minimizing secondary ventilator-associated lung injury. The only ventilator currently available that delivers HFPV is the volume diffusive respirator (VDR-4; Percussionaire Corp, Sandpoint, Idaho). High-frequency percussive ventilation is delivered via a pneumatically powered, pressure-limited, time-cycled, high-frequency flow interrupter and provides small tidal volumes with 300 to 700 oscillations per minute. Following transition to HFPV, respiratory status often stabilizes or improves within a few hours. The unique gas flow mobilizes significant volumes of pulmonary secretions, further facilitating gas exchange. This article reviews the operating principles of HFPV, the functional components of the VDR-4, and the special nursing care considerations to include sedation, hemodynamic assessment, skin and oral care, nutrition, and weaning from ventilation.
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7

Kunugiyama, Sujen K., and Christine S. Schulman. "High-Frequency Percussive Ventilation Using the VDR-4 Ventilator." AACN Advanced Critical Care 23, no. 4 (2012): 370–80. http://dx.doi.org/10.1097/nci.0b013e31826e9031.

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8

Gallagher, T. James, Philip G. Boysen, Dwight D. Davidson, James R. Miller, and Steven B. Leven. "HIGH FREQUENCY PERCUSSIVE VENTILATION COMPARED WITH CONVENTIONAL MECHANICAL VENTILATION." Critical Care Medicine 13, no. 4 (April 1985): 312. http://dx.doi.org/10.1097/00003246-198504000-00075.

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9

GALLAGHER, T. JAMES, PHILIP G. BOYSEN, DWIGHT D. DAVIDSON, JAMES R. MILLER, and STEVEN B. LEVEN. "High-frequency percussive ventilation compared with conventional mechanical ventilation." Critical Care Medicine 17, no. 4 (April 1989): 364–66. http://dx.doi.org/10.1097/00003246-198904000-00013.

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10

Starnes-Roubaud, Margaret, Elizabeth A. Bales, Alex Williams-Resnick, Philip D. Lumb, Joe A. Escudero, Linda S. Chan, and Warren L. Garner. "High frequency percussive ventilation and low FiO2." Burns 38, no. 7 (November 2012): 984–91. http://dx.doi.org/10.1016/j.burns.2012.05.026.

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11

Benn, Francis, Ashwad Afzal, Berhane Worku, Felix Khusid, Bashar H. Fahoum, and Iosif Gulkarov. "Use of High-Frequency Percussive Ventilation to Expand Organ Donor Pool." Journal of Intensive Care Medicine 33, no. 4 (May 19, 2017): 267–69. http://dx.doi.org/10.1177/0885066617709969.

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A 34-year-old woman was brought in to the emergency department after a motor vehicle accident. She had signs of traumatic head injury with Glasgow Coma Scale score of 3, and her neurological examination was consistent with brain death. She was persistently hypoxic on conventional mechanical ventilation and high-frequency percussive ventilation was initiated. The patient’s oxygenation improved and was sustained long enough to provide time for organ procurement. This is the first case portraying high-frequency percussive ventilation as a bridge for donors failing on conventional mechanical ventilation.
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12

Allan, Patrick, Sahar Abouchahine, Gregory Ruff, Michael Van de Kieft, and Jefferson Thurlby. "PULSATILE INSPIRATORY:EXPIRATORY RATIOS AND FREQUENCY AFFECTS VENTILATION DURING HIGH FREQUENCY PERCUSSIVE VENTILATION." Critical Care Medicine 33 (December 2005): A110. http://dx.doi.org/10.1097/00003246-200512002-00392.

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13

Barillo, MD, FACS, FCCM, COL David J., Evan M. Renz, MD, SFC Gabriel R. Wright, CRT, MAJ Kristine P. Broger, CCRN, LTC Kevin K. Chung, MD, Charles K. Thompson, PA-C, and Leopoldo C. Cancio, MD, FACS. "High-frequency percussive ventilation for intercontinental aeromedical evacuation." American Journal of Disaster Medicine 6, no. 6 (November 1, 2011): 369–78. http://dx.doi.org/10.5055/ajdm.2011.0075.

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14

KEARS, ALAYNNA, CHRISTOPHER LENIVY, KAITLYN MUSCO, ROSHUN SANGANI, and DANIEL SCHWED LUSTGARTEN. "USE OF HIGH FREQUENCY PERCUSSIVE VENTILATION FOR ARDS." Chest 160, no. 4 (October 2021): A951. http://dx.doi.org/10.1016/j.chest.2021.07.886.

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15

Hiller, Kenneth N., and Christopher K. Morgan. "High-frequency Percussive Ventilation for Severe Inhalation Injury." Anesthesiology 120, no. 4 (April 1, 2014): 998. http://dx.doi.org/10.1097/aln.0b013e31828ce85c.

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16

Ray, Kristi L., Robert J. Apsey, Jeff L. Heltborg, Chae L. Bliss, and Enoch T. Huang. "Performance characteristics of high-frequency percussive ventilation under hyperbaric conditions." Undersea and Hyperbaric Medicine 03, no. 01 (March 1, 2021): 157–68. http://dx.doi.org/10.22462/03.04.2021.6.

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Introduction: Safe administration of critical care hyperbaric medicine requires specialized equipment and advanced training. Equipment must be tested in order to evaluate function in the hyperbaric environment. High-frequency percussive ventilation (HFPV) has been used in intensive care settings effectively, but it has never been tested in a hyperbaric chamber. Methods: Following a modified U.S. Navy testing protocol used to evaluate hyperbaric ventilators, we evaluated an HFPV transport ventilator in a multiplace hyperbaric chamber at 1.0, 1.9, and 2.8 atmospheres absolute (ATA). We used a test lung with analytical software for data collection. The ventilator uses simultaneous cyclic pressure-controlled ventilation at a pulsatile flow rate (PFR)/oscillatory continuous positive airway pressure (oCPAP) ratio of 30/10 with a high-frequency oscillation percussive rate of 500 beats per minute. Inspiratory and expiratory times were maintained at two seconds throughout each breathing cycle. Results: During manned studies, the PFR/oCPAP ratios were 26/6, 22/7, and 22.5/8 at an airway resistance of 20cm H2O/L/second and 18/9, 15.2/8.5, and 13.6/7 at an airway resistance of 50 cm/H2O/L/second at 1, 1.9, and 2.8 ATA. The resulting release volumes were 800, 547, and 513 mL at airway resistance of 20 cm H2O/L/sec and 400, 253, and 180 mL at airway resistance of 50 cm/H2O/L/sec at 1, 1.9, and 2.8 ATA. Unmanned testing showed similar changes. The mean airway pressure (MAP) remained stable throughout all test conditions; theoretically, supporting adequate lung recruitment and gas exchange. A case where HFPV was used to treat a patient for CO poisoning was presented to illustrate that HFPV worked well under HBO2 conditions and no complications occurred during HBO2 treatment. Conclusion: The HFPV transport ventilator performed adequately under hyperbaric conditions and should be considered a viable option for hyperbaric critical care. This ventilator has atypical terminology and produces unique pulmonary physiology, thus requiring specialized training prior to use.
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17

Galustanian, Lusanik. "High Frequency Percussive Ventilation, a County Medical Center Experience." Chest 148, no. 4 (October 2015): 304A. http://dx.doi.org/10.1378/chest.2271736.

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18

Hall, Jason J., John L. Hunt, Brett D. Arnoldo, and Gary F. Purdue. "Use of High-Frequency Percussive Ventilation in Inhalation Injuries." Journal of Burn Care & Research 28, no. 3 (May 2007): 396–400. http://dx.doi.org/10.1097/bcr.0b013e318053d2d6.

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19

Allan, Patrick F., Cindy A. Codispoti, Shannon G. Womble, Michael L. Overton, Sandra M. Wanek, John H. Sherner, Raymond Fang, and Steven V. Silvey. "Inhaled Prostacyclin in Combination With High-Frequency Percussive Ventilation." Journal of Burn Care & Research 31, no. 2 (March 2010): 347–52. http://dx.doi.org/10.1097/bcr.0b013e3181d0f5a1.

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20

CIOFFI, WILLIAM G., THERESA A. GRAVES, WILLIAM F. McMANUS, and BASIL A. PRUITT. "High-frequency Percussive Ventilation in Patients with Inhalation Injury." Journal of Trauma: Injury, Infection, and Critical Care 29, no. 3 (March 1989): 350–54. http://dx.doi.org/10.1097/00005373-198903000-00012.

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21

Hall, J. J., G. F. Purdue, B. D. Arnoldo, and J. L. Hunt. "Use of High Frequency Percussive Ventilation in Inhalation Injuries." Journal of Burn Care & Research 27, Supplement (March 2006): S75. http://dx.doi.org/10.1097/01253092-200603001-00054.

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22

Sala, Ina M., Girish B. Nair, Beverly Maurer, and Thomas M. Guerrero. "High frequency percussive ventilation for respiratory immobilization in radiotherapy." Technical Innovations & Patient Support in Radiation Oncology 9 (March 2019): 8–12. http://dx.doi.org/10.1016/j.tipsro.2018.11.001.

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23

Sala, I. M., B. A. Maurer, N. K. Myziuk, C. W. Stevens, and T. M. Guerrero. "High Frequency Percussive Ventilation for Chest Wall Motion Immobilization." International Journal of Radiation Oncology*Biology*Physics 102, no. 3 (November 2018): S206. http://dx.doi.org/10.1016/j.ijrobp.2018.07.113.

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24

Wong, Ivan, Berhane Worku, Jeremy A. Weingarten, Alexander Ivanov, Felix Khusid, Ashwad Afzal, Robert F. Tranbaugh, and Iosif Gulkarov. "High-frequency percussive ventilation in cardiac surgery patients failing mechanical conventional ventilation†." Interactive CardioVascular and Thoracic Surgery 25, no. 6 (July 21, 2017): 937–41. http://dx.doi.org/10.1093/icvts/ivx237.

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25

Platteau, S., L. Foubert, F. Van Praet, G. Cammu, J. Coddens, and T. Deloof. "High-frequency percussive ventilation during one-lung ventilation for robotically enhanced MIDCAB." European Journal of Anaesthesiology 21, Supplement 32 (June 2004): 78. http://dx.doi.org/10.1097/00003643-200406002-00283.

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26

Velmahos, George C., Linda S. Chan, Raymond Tatevossian, Edward E. Cornwell, William R. Dougherty, Joe Escudero, and Demetrios Demetriades. "High-frequency Percussive Ventilation Improves Oxygenation in Patients With ARDS." Chest 116, no. 2 (August 1999): 440–46. http://dx.doi.org/10.1378/chest.116.2.440.

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27

Kodali, Lavanya, Emile Klada, Ruchi Bansal, Adebayo Esan, Felix Khusid, and Suhail Raoof. "High Frequency Percussive Ventilation in the Management of Acute Asthma." Chest 140, no. 4 (October 2011): 136A. http://dx.doi.org/10.1378/chest.1119768.

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28

Kacmarek, Robert M., and Jesús Villar. "Clinical repercussions of high-frequency percussive ventilation: A burning issue*." Critical Care Medicine 38, no. 10 (October 2010): 2069–70. http://dx.doi.org/10.1097/ccm.0b013e3181f178cb.

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29

Cortiella, Joaquin, Ron Mlcak, and David Herndon. "High Frequency Percussive Ventilation in Pediatric Patients With Inhalation Injury." Journal of Burn Care & Rehabilitation 20, no. 3 (May 1999): 232–35. http://dx.doi.org/10.1097/00004630-199905000-00014.

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30

Reper, P., O. Wibaux, P. Van Laeke, D. Vandeenen, L. Duinslaeger, and A. Vanderkelen. "High frequency percussive ventilation and conventional ventilation after smoke inhalation: a randomised study." Burns 28, no. 5 (August 2002): 503–8. http://dx.doi.org/10.1016/s0305-4179(02)00051-7.

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31

Giacomino, Katia, Roger Hilfiker, Tina Magnin, and Lara Allet. "A systematic review on the effects of high frequency chest wall compression and intrapulmonary percussive ventilation in patients with neuromuscular disease." F1000Research 10 (January 8, 2021): 10. http://dx.doi.org/10.12688/f1000research.27833.1.

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Background: Respiratory insufficiency is the most common cause of mortality among patients with a neuromuscular disease. Methods: We explored the effects of high frequency wall compression and intrapulmonary percussive ventilation, compared with standard care or no treatment, on the lung volume and capacity, and quality of life in patients with neuromuscular disease during respiratory infections or in stable periods. We further assessed the effects of these two interventions on clinical value, complications, and survival. The literature search was performed on Embase, MEDLINE, CINAHL, CENTRAL and PEDro. Randomised controlled trials and cross-over studies were eligible. Results: Five studies were included, and results were presented narratively. High frequency wall compression was not shown to be superior to standard care in terms of lung volume and capacity, quality of life, complications, and survival rate. Compared with standard care, intrapulmonary percussive ventilation showed non-significant differences in terms of lung volume and capacity, and the risk of respiratory infection. Standard care was nevertheless associated with a significantly higher risk of days of hospitalisation (Incidence Rate Ratio 8.5 [1.1-67]) and of antibiotic use than intrapulmonary percussive ventilation (Incidence Rate Ratio 43 [6-333]). Conclusions: Due to large variety of reported outcomes, missing data and limited number of studies, no meta-analysis could be conducted. The results should be interpreted with caution as the results have a very low certainty of evidence and reported outcomes have a high risk of bias. The evidence for high frequency wall compression and intrapulmonary percussive ventilation is still insufficient to draw final conclusions. Protocol registration: PROSPERO ID: CRD42017064703.
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32

Giacomino, Katia, Roger Hilfiker, Tina Magnin, and Lara Allet. "A systematic review on the effects of high frequency chest wall compression and intrapulmonary percussive ventilation in patients with neuromuscular disease." F1000Research 10 (January 8, 2021): 10. http://dx.doi.org/10.12688/f1000research.27833.1.

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Background: Respiratory insufficiency is the most common cause of mortality among patients with a neuromuscular disease. Methods: We explored the effects of high frequency wall compression and intrapulmonary percussive ventilation, compared with standard care or no treatment, on the lung volume and capacity, and quality of life in patients with neuromuscular disease during respiratory infections or in stable periods. We further assessed the effects of these two interventions on clinical value, complications, and survival. The literature search was performed on Embase, MEDLINE, CINAHL, CENTRAL and PEDro. Randomised controlled trials and cross-over studies were eligible. Results: Five studies were included, and results were presented narratively. High frequency wall compression was not shown to be superior to standard care in terms of lung volume and capacity, quality of life, complications, and survival rate. Compared with standard care, intrapulmonary percussive ventilation showed non-significant differences in terms of lung volume and capacity, and the risk of respiratory infection. Standard care was nevertheless associated with a significantly higher risk of days of hospitalisation (Incidence Rate Ratio 8.5 [1.1-67]) and of antibiotic use than intrapulmonary percussive ventilation (Incidence Rate Ratio 43 [6-333]). Conclusions: Due to large variety of reported outcomes, missing data and limited number of studies, no meta-analysis could be conducted. The results should be interpreted with caution as the results have a very low certainty of evidence and reported outcomes have a high risk of bias. The evidence for high frequency wall compression and intrapulmonary percussive ventilation is still insufficient to draw final conclusions. Protocol registration: PROSPERO ID: CRD42017064703.
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33

Korzhuk, Anatoliy, Ashwad Afzal, Ivan Wong, Felix Khusid, Berhane Worku, and Iosif Gulkarov. "High-Frequency Percussive Ventilation Rescue Therapy in Morbidly Obese Patients Failing Conventional Mechanical Ventilation." Journal of Intensive Care Medicine 35, no. 6 (April 22, 2018): 583–87. http://dx.doi.org/10.1177/0885066618769596.

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Background: Morbidly obese patients with respiratory failure who do not improve on conventional mechanical ventilation (CMV) often undergo rescue therapy with extracorporeal membrane oxygenation (ECMO). We describe our experience with high-frequency percussive ventilation (HFPV) as a rescue modality. Methods: In a retrospective analysis from 2009 to 2016, 12 morbidly obese patients underwent HFPV after failing to wean from CMV. Data were collected regarding demographics, cause of respiratory failure, ventilation settings, and hospital course outcomes. Our end point data were pre- and post-HFPV partial pressure of arterial oxygen and PaO2 to fraction of inspired oxygen (PF) ratios measured at initiation, 2, and 24 hours. Results: Twelve morbidly obese patients required HFPV for respiratory failure. Causes of respiratory failure overlapped and included cardiogenic pulmonary edema (n = 8), pneumonia (n = 5), septic shock (n = 5), and asthma (n = 1). After HFPV initiation, mean fraction of inspired oxygen FiO2 was tapered from 98% to 82% and 66% at 2 and 24 hours, respectively. Mean PaO2 increased from 60.9 mm Hg before HFPV to 175.1 mm Hg ( P < .05) at initiation of HFPV, then sustained at 129.5 mm Hg ( P < .05) and 88.1 mm Hg ( P < .005) at 2 and 24 hours, respectively. Mean PF ratio improved from 66.1 before HFPV to 180.3 ( P < .05), 181.0 ( P < .05) and 148.9 ( P < .0005) at initiation, 2, and 24 hours, respectively. The improvement in mean PaO2 and PF ratios was durable at 24 hours whether or not the patient was returned to CMV (n = 10) or remained on HFPV (n = 2). Survival to discharge was 66.7%. Conclusion: In our cohort of morbidly obese patients, HFPV was successfully utilized as a rescue therapy precluding the need for ECMO. Despite our small sample size, HFPV should be considered as a rescue therapy in morbidly obese patients failing CMV prior to the initiation of ECMO. Our retrospective analysis supports consideration for HFPV as another form of rescue therapy for obese patients with refractory hypoxemia and respiratory failure who are not improving with CMV.
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34

Dries, D. J. "High-frequency percussive ventilation improves perioperatively clinical evolution in pulmonary resection." Yearbook of Critical Care Medicine 2011 (January 2011): 27–29. http://dx.doi.org/10.1016/s0734-3299(10)79421-1.

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35

HURST, JAMES M., RICHARD D. BRANSON, and KENNETH DAVIS. "High-frequency Percussive Ventilation in the Management of Elevated Intracranial Pressure." Journal of Trauma: Injury, Infection, and Critical Care 28, no. 9 (September 1988): 1363–67. http://dx.doi.org/10.1097/00005373-198809000-00010.

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36

Reper, P., R. Van Bos, K. Van Loey, P. Van Laeke, and A. Vanderkelen. "High frequency percussive ventilation in burn patients: hemodynamics and gas exchange." Burns 29, no. 6 (September 2003): 603–8. http://dx.doi.org/10.1016/s0305-4179(03)00068-8.

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37

Kinthala, Sudhakar, Mark Liang, Felix Khusid, and Sebron Harrison. "The Use of High-Frequency Percussive Ventilation for Whole-Lung Lavage." A & A Practice 11, no. 8 (October 2018): 205–7. http://dx.doi.org/10.1213/xaa.0000000000000778.

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38

Lucangelo, Umberto, Vittorio Antonaglia, Walter A. Zin, Marco Confalonieri, Massimo Borelli, Mario Columban, Silvio Cassio, et al. "High-frequency percussive ventilation improves perioperatively clinical evolution in pulmonary resection*." Critical Care Medicine 37, no. 5 (May 2009): 1663–69. http://dx.doi.org/10.1097/ccm.0b013e31819ef9e1.

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39

Blanch, Luis, Jesús Villar, and J. López Aguilar. "High-frequency percussive ventilation: An old mode with a great future*." Critical Care Medicine 37, no. 5 (May 2009): 1810–11. http://dx.doi.org/10.1097/ccm.0b013e3181a0923a.

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40

Giacomino, Katia, Roger Hilfiker, Tina Magnin, and Lara Allet. "A systematic review on the effects of high frequency chest wall compression and intrapulmonary percussive ventilation in patients with neuromuscular disease." F1000Research 10 (June 21, 2022): 10. http://dx.doi.org/10.12688/f1000research.27833.2.

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Background: Respiratory insufficiency is the most common cause of mortality among patients with a neuromuscular disease. Methods: We followed the PRISMA statement for systematic reviews. We explored the effects of high frequency wall compression and intrapulmonary percussive ventilation, compared to a control intervention, on the lung volume and capacity, and quality of life in patients with neuromuscular disease. We further assessed the effects of these two interventions on clinical value, complications, and survival. The literature search was performed on 30/06/2020 in Embase, MEDLINE, CENTRAL, PEDro and CINAHL on 6/07/2020. Inclusion criteria: patients with neuromuscular disease; interventions of interest mentioned above; randomised controlled trials comparing these interventions with a control intervention. Results: Five studies were included, and results were presented narratively. High frequency wall compression was not shown to be superior to standard care in terms of lung volume and capacity, quality of life, complications, and survival rate. Compared with standard care, intrapulmonary percussive ventilation showed non-significant differences in terms of lung volume and capacity, and the risk of respiratory infection. Standard care was nevertheless associated with a significantly higher risk of days of hospitalisation (Incidence Rate Ratio 8.5 [1.1-67]) and of antibiotic use than intrapulmonary percussive ventilation (Incidence Rate Ratio 43 [6-333]). The assessment with the risk of bias tool 2.0 showed a high risk of bias for all outcomes. Moreover, the evidence is of very low-quality for all outcomes. Conclusions: Due to large variety of reported outcomes, missing data and limited number of studies, no meta-analysis could be conducted. The results should be interpreted with caution as the results have a very low certainty of evidence and reported outcomes have a high risk of bias. The evidence for high frequency wall compression and intrapulmonary percussive ventilation is still insufficient to draw final conclusions. Registration: PROSPERO ID: CRD42017064703.
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41

Renesme, L., C. Elleau, P. Nolent, M. Fayon, and E. Dumas De La Roque. "Comparative study of high frequency percussive ventilation, high frequency ventilation by oscillation and conventional ventilation in a piglet model of meconium aspiration." Paediatric Respiratory Reviews 12 (June 2011): S63. http://dx.doi.org/10.1016/s1526-0542(11)70052-5.

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42

Miller, Andrew C., Paula A. Ferrada, Sameer S. Kadri, Krupa Nataraj-Bhandari, Amir Vahedian-Azimi, and Sadeq A. Quraishi. "High-Frequency Ventilation Modalities as Salvage Therapy for Smoke Inhalation–Associated Acute Lung Injury: A Systematic Review." Journal of Intensive Care Medicine 33, no. 6 (June 26, 2017): 335–45. http://dx.doi.org/10.1177/0885066617714770.

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Background: Smoke inhalation–associated acute lung injury (SI-ALI) is a major cause of morbidity and mortality in victims of fire tragedies. To date, there are no evidence-based guidelines on ventilation strategies in acute respiratory distress syndrome (ARDS) after smoke inhalation. We reviewed the existing literature for clinical studies of salvage mechanical ventilation (MV) strategies in patients with SI-ALI, focusing on mortality and pneumonia as outcomes. Methods: A systematic search was designed in accordance with preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Risk of bias assessment was performed using the Newcastle-Ottawa Quality Assessment Scale (NOS; 0 to 9 stars), with a score ≥7 being the threshold for inclusion in the meta-analysis. A systematic search strategy was used to search 10 databases. Clinical studies were included in which patients: (1) experienced smoke inhalation, (2) treated with MV, and (3) described a concurrent or historical control group. Results: A total of 226 potentially relevant studies were identified, of which 7 studies on high-frequency percussive ventilation (HFPV) met inclusion criteria. No studies met inclusion for meta-analysis (NOS ≥ 7). In studies comparing HFPV to conventional mechanical ventilation (CMV), mortality and pneumonia incidence improved in 3 studies and remained unchanged in 3 others. No change in ventilator days or ICU length of stay was observed; however, oxygenation and work of breathing improved with HFPV. Conclusions: Mechanical ventilation in patients with SI-ALI has not been well studied. High-frequency percussive ventilation may decrease in-hospital mortality and pneumonia incidence when compared to CMV. The absence of “good” quality evidence precluded meta-analysis. Based upon low-quality evidence, there was a very weak recommendation that HFPV use may be associated with lower mortality and pneumonia rates in patients with SI-ALI. Given SI-ALI’s unique underlying pathophysiology, and its potential implications on therapy, randomized controlled studies are required to ensure that patients receive the safest and most effective care. Trial Registration: The study was registered with PROSPERO International prospective register of systematic reviews (#47015).
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43

Byerly, Faera L., Bruce A. Cairns, Kathy A. Short, John A. Haithcock, Lynn Shapiro, Alvis Page, and Philip Boysen. "HIGH FREQUENCY PERCUSSIVE VENTILATION CAN MIMIC AIRWAY PRESSURE RELEASE VENTILATION IN A TEST LUNG MODEL." Critical Care Medicine 32, Supplement (December 2004): A38. http://dx.doi.org/10.1097/00003246-200412001-00144.

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Mozingo, D. W. "High-frequency percussive ventilation and low tidal volume ventilation in burns: A randomized controlled trial." Yearbook of Surgery 2011 (January 2011): 56–58. http://dx.doi.org/10.1016/j.ysur.2011.04.127.

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Chung, Kevin K., Steven E. Wolf, Evan M. Renz, Patrick F. Allan, James K. Aden, Gerald A. Merrill, Mehdi C. Shelhamer, et al. "High-frequency percussive ventilation and low tidal volume ventilation in burns: A randomized controlled trial*." Critical Care Medicine 38, no. 10 (October 2010): 1970–77. http://dx.doi.org/10.1097/ccm.0b013e3181eb9d0b.

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46

Rizkalla, Nicole A., Cheryl L. Dominick, Julie C. Fitzgerald, Neal J. Thomas, and Nadir Yehya. "High-frequency percussive ventilation improves oxygenation and ventilation in pediatric patients with acute respiratory failure." Journal of Critical Care 29, no. 2 (April 2014): 314.e1–314.e7. http://dx.doi.org/10.1016/j.jcrc.2013.11.009.

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CIOFFI, WILLIAM G., LORING W. RUE, THERESA A. GRAVES, WILLIAM F. McMANUS, ARTHUR D. MASON, and BASIL A. PRUITT. "Prophylactic Use of High-frequency Percussive Ventilation in Patients with Inhalation Injury." Annals of Surgery 213, no. 6 (June 1991): 575–82. http://dx.doi.org/10.1097/00000658-199106000-00007.

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48

Yehya, Nadir, Cheryl L. Dominick, James T. Connelly, Daniela H. Davis, Peter C. Minneci, Katherine J. Deans, John J. McCloskey, and Todd J. Kilbaugh. "High-Frequency Percussive Ventilation and Bronchoscopy During Extracorporeal Life Support in Children." ASAIO Journal 60, no. 4 (2014): 424–28. http://dx.doi.org/10.1097/mat.0000000000000088.

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Feltracco, P., E. Serra, S. Barbieri, M. Milevoj, E. Michieletto, C. Carollo, F. Rea, G. Zanus, R. Boetto, and C. Ori. "Noninvasive High-Frequency Percussive Ventilation in the Prone Position after Lung Transplantation." Transplantation Proceedings 44, no. 7 (September 2012): 2016–21. http://dx.doi.org/10.1016/j.transproceed.2012.05.062.

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Hurst, James M., Richard D. Branson, C. Bryan DeHaven, Kenneth Davis, and Karen S. Adams. "COMPARISON OF INTERMITTENT MANDATORY VENTILATION(IMV) AND HIGH-FREQUENCY PERCUSSIVE VENTILATION(HFPV) IN ACUTE RESPIRATORY FAILURE." Critical Care Medicine 14, no. 4 (April 1986): 354. http://dx.doi.org/10.1097/00003246-198604000-00089.

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