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Journal articles on the topic 'HG-SOC'

Author: Grafiati

Published: 1 April 2023

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1

Zhu, Sihua, Caiyun Yang, Hong Chen, et al. "Organic Carbon Controls Mercury Distribution and Storage in the Surface Soils of the Water-Level-Fluctuation Zone in the Three Gorges Reservoir Region, China." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 3681. http://dx.doi.org/10.3390/ijerph20043681.

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The particular condition of the water-level-fluctuation zone (WLFZ) in the Three Gorges Reservoir (TGR), the largest hydroelectric reservoir in China, raises great concerns about mercury (Hg) contamination and ecological risk. In addition, previous research found that soil organic carbon (SOC) plays an essential role in controlling Hg distribution and speciation. However, there is minimal information on the Hg storage distribution and their relationships with SOC in the WLFZ in TGR. This study investigated Hg distribution, storage, and their relationships with SOC in the surface soils in WLFZ.

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2

Topp, Monique, Lynne Hartley, Michele Cook, et al. "Targeting therapy based on preclinical analysis of clinical, molecular, and functional characteristics of individual high-grade serous ovarian cancers." Journal of Clinical Oncology 30, no. 15_suppl (2012): 5073. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5073.

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5073 Background: Recent molecular exploration of high-grade epithelial ovarian cancer (OC) has revealed potential targets for novel therapy based on altered DNA repair function, deregulated pathways and recurrent amplifications (Cancer Genome Atlas Research Network. 2011. Nature 474). Improved pre-clinical models allowing analysis of specific molecular subsets of ovarian cancer are urgently required to test novel treatment strategies. Methods: We have generated a novel xenograft model of human high-grade serous OC (HG-SOC). Histologic, functional and molecular analysis of the novel xenograft c

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3

He, Ling, and Xiuhong Peng. "Content and Bioavailability of Hg in a Soil–Tea Plant System in Anxi Area, Southeast China." Water 15, no. 1 (2023): 179. http://dx.doi.org/10.3390/w15010179.

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Many studies on the bioavailability of Hg in soil–plant systems have been conducted. However, studies on the soil–tea plant system are still limited. In this study, we collected soil and tea leaf samples from 69 tea gardens in the Anxi area in China. We investigated the Hg contents in tea leaves and soil, and the bioavailability of Hg from soil to tea leaves. The results showed the following: (1) The Hg content in soil was equivalent to the background value in Fujian province and was 2.6–2.9 times higher of the national background value in China. For different geological backgrounds, the Hg co

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4

Sakoulas, George, Matthew Geriak, Ravina Kullar, et al. "71. Use of Intravenous Immunoglobulin Therapy Reduces Progression to Mechanical Ventilation in COVID-19 Patients with Moderate to Severe Hypoxia." Open Forum Infectious Diseases 7, Supplement_1 (2020): S166. http://dx.doi.org/10.1093/ofid/ofaa439.381.

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Abstract Background The majority of COVID-19 morbidity and mortality occurs in patients who progress to mechanical ventilation. Therefore, therapeutic interventions targeting the mitigation of this complication would markedly improve outcomes and reduce healthcare utilization. Methods Patients with COVID-19 from two hospitals in San Diego, California were randomized at a 1:1 ratio to receive standard of care (SOC) plus intravenous immunoglobulin (IVIG) at 0.5 g/kg/day x 3 days with solumedrol 40 mg 30 minutes before infusion (IVIG group) versus SOC alone. The primary composite endpoint was rec

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5

Alemayehu, Denekew, Bhagwan Singh Chandravanshi Chandravanshi, Tesfu Hailu, and Merid Tessema. "Square wave anodic stripping voltammetric determination of Hg(II) with N-p- chlorophenylcinnamohydroxamic acid modified carbon paste electrode." Bulletin of the Chemical Society of Ethiopia 34, no. 1 (2020): 25–39. http://dx.doi.org/10.4314/bcse.v34i1.3.

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A new method has been developed for the electrochemical determination of Hg(II) with N-p-chlorophenylcinnamohydroxamic acid (CPCHA) modified carbon paste electrode by square wave anodic stripping voltammetry (SWASV). Hg(II) was accumulated on the electrode surface by the formation of the complex in an open circuit and the resulting surface was characterized by electrochemical reduction and stripping. The optimum voltammetric response was observed using a carbon paste composition of 7.5% (w/w) CPCHA and preconcentration time of 210 s in 0.1 M sodium acetate at pH 8 followed by electrochemical S

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6

Qu, Rui, and Guilin Han. "The Grain for Green Project May Enrich the Mercury Concentration in a Small Karst Catchment, Southwest China." Land 9, no. 10 (2020): 354. http://dx.doi.org/10.3390/land9100354.

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The Chinese project, better known as the Grain for Green Project (GGP), has changed the land-use type in the karst area of Puding county, Guizhou province, southwest China, and this study is aimed at evaluating the Hg distribution and determining factors in soils after the land-use change. A total of ten soil profiles were selected in the typical karst region, and the land-use types were divided into native vegetation land (NVL), farmland (FL), and abandoned farmland (AFL). Total Hg concentration under different land-use types increased in the order: NVL (average 63.26 μg∙kg−1) < FL (averag

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7

Hao, Xinghai, Juejie Yang, Shikui Dong, et al. "Impacts of Short-Term Grazing Intensity on the Plant Diversity and Ecosystem Function of Alpine Steppe on the Qinghai–Tibetan Plateau." Plants 11, no. 14 (2022): 1889. http://dx.doi.org/10.3390/plants11141889.

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Livestock grazing is the primary land use of grasslands worldwide. Grazing has been asserted to alter grassland ecosystem functions, such as productivity, nutrient cycling, and biodiversity conservation. However, few studies have focused on the impact of grazing intensity on the ecosystem multifunctionality (EMF) of alpine grasslands. We conducted a field experiment of manipulating sheep grazing intensity effects on alpine steppe by surveying plant community characteristics and ecosystem functions. Our results showed that plant community composition was altered with increasing grazing intensit

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Farley, John H., William E. Brady, Michael J. Birrer, David Marc Gershenson, and Gini F. Fleming. "An evaluation of survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: A Gynecologic Oncology Group experience." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5534. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5534.

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5534 Background: We examined disparities in prognosis between patients with ovarian clear cell carcinoma (OCCC) and serous epithelial ovarian cancer (SOC). Methods: Data from stage I-IV epithelial ovarian cancer (EOC) patients who participated in 12 randomized GOG protocols using platinum-based chemotherapy were reviewed. Proportional hazards models adjusted for age and stratified by protocol, treatment arm, stage, performance status (PS), and race were used to compare progression-free survival (PFS) and overall survival (OS) by cell type (clear cell versus serous). Results: There were 10,803

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9

Wang, Z., D. A. Johnson, and Y. Rong. "Grazing effects on soil characteristics and vegetation of grassland in northern China." Solid Earth Discussions 7, no. 3 (2015): 2283–309. http://dx.doi.org/10.5194/sed-7-2283-2015.

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Abstract. Large areas of grassland in the agro-pastoral region of northern China were converted into cropland for grain production, and the remaining grasslands are being overgrazed and seriously degraded. The objective of this study was to evaluate how reductions in grazing intensity affect the soil and vegetation characteristics in grasslands of northern China. Soil heterogeneity and vegetation characteristics were evaluated for ungrazed (UG), moderate grazing (MG), and heavy grazing (HG) sites. Grazing increased diversity, but heavy grazing decreased aboveground biomass and increased the no

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Uttarwar, Lalita, Bo Gao, Alistair J. Ingram та Joan C. Krepinsky. "SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells". American Journal of Physiology-Renal Physiology 302, № 3 (2012): F329—F341. http://dx.doi.org/10.1152/ajprenal.00136.2011.

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Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent studies showed that overexpression of the transcription factor sterol-responsive element-binding protein (SREBP)-1 induces pathology reminiscent of diabetic nephropathy, and SREBP-1 upregulation was observed in diabetic kidneys. We thus studied whether SREBP-1 is activated by high glucose (HG) and mediates its profibrogenic responses. In primary rat mesangial cells, HG activated SREBP-1 by 30 min, seen by the appearance of its cleaved nuclear form (nSREBP-1), EMSA, and by activation of an SREBP-1 response element (SRE

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Wang, Z., D. A. Johnson, Y. Rong, and K. Wang. "Grazing effects on soil characteristics and vegetation of grassland in northern China." Solid Earth 7, no. 1 (2016): 55–65. http://dx.doi.org/10.5194/se-7-55-2016.

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Abstract. Large areas of grassland in the agro-pastoral region of northern China were converted into cropland for grain production, and the remaining grasslands are being overgrazed and seriously degraded. The objective of this study was to evaluate how reductions in grazing intensity affect the soil and vegetation characteristics in grasslands of northern China. Soil heterogeneity and vegetation characteristics were evaluated for ungrazed (UG), moderate grazing (MG), and heavy grazing (HG) sites. Grazing increased diversity, but heavy grazing decreased aboveground biomass and increased the no

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12

P. Onyedinma, U., Siddhant, E. C. Nwaru, P. O. Chukwu, A. B. Ajong, and F. Dehmchi. "Evaluation of risk caused by intake of trace metal through consumption of Pleurotus tuber-regium collected around automobile village in Abia State." Bulletin of the Chemical Society of Ethiopia 35, no. 2 (2021): 229–41. http://dx.doi.org/10.4314/bcse.v35i2.2.

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ABSTRACT. The bioaccumulation of trace metals in mushrooms poses a health risk to consumers. Despite the fact that mushroom eating has been linked to numerous health advantages, little attention has been paid to the relative health risks associated with trace metal build-up in this nutritional source in Nigeria. Pb, Cd, Fe, Hg and As in Pleurotus tuber-regium collected from mechanic workshops in Umuahia were analysed and the associated health risks for the consumers were evaluated. The trace metal contents in the mushroom and its substrates showed a descending order of Fe > Pb > Cd >

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13

Liu, Yanmei, Hangyu Yang, Zisheng Xing, Yali Zou, and Zheming Cui. "Vegetation Degradation of Guanshan Grassland Suppresses the Microbial Biomass and Activity of Soil." Land 10, no. 2 (2021): 203. http://dx.doi.org/10.3390/land10020203.

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Changes in vegetation influence the function of grassland ecosystems. A degradation of the vegetation type has been found from high to low altitudes in Guanshan grassland in the order of forest grassland (FG) < shrub grassland (SG) < herb grassland (HG). However, there is poor information regarding the effect of vegetation degradation on soil microbes in Guanshan grassland. Therefore, our study evaluated the impact of vegetation degradation on the microbial parameters of soil, as well as the mechanisms responsible for these variations. Soils were sampled from 0 to 30 cm under the FG, SG,

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14

Nuralykyzy, Bayan, Pan Wang, Xiaoqian Deng, Shaoshan An, and Yimei Huang. "Heavy Metal Contents and Assessment of Soil Contamination in Different Land-Use Types in the Qaidam Basin." Sustainability 13, no. 21 (2021): 12020. http://dx.doi.org/10.3390/su132112020.

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Due to the unique geographical location and rapid development in the agricultural industry, heavy metals’ risk of soil contamination in the Qaidam Basin is gradually increasing. The following study was conducted to determine the soil heavy metal contents under different types of land use, contamination levels, and the physicochemical properties of soil. Soil samples were collected from facility lands, orchards, farmlands, and grasslands at 0–10 and 10–20 cm soil layers. Heavy metals including copper (Cu), chromium (Cr), nickel (Ni), zinc (Zn), lead (Pb), cadmium (Cd), arsenic (As), and mercury

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15

Wang, Jinlan, Wen Li, Wenxia Cao, and Shilin Wang. "Effects of different intensities of long-term grazing on plant diversity, biomass and carbon stock in alpine shrubland on the Qinghai-Tibetan Plateau." PeerJ 10 (January 12, 2022): e12771. http://dx.doi.org/10.7717/peerj.12771.

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Grazing is the main grassland management strategy applied in alpine shrubland ecosystems on the Qinghai-Tibetan Plateau. However, how different intensities of long-term grazing affect plant diversity, biomass accumulation and carbon (C) stock in these ecosystems is poorly understood. In this study, alpine shrubland with different long-term (more than 30 years) grazing intensities (excluded from grazing for 5 years (EX), light grazing (LG), moderate grazing (MG) and heavy grazing (HG)) on the Qinghai-Tibetan Plateau were selected to study changes in plant diversity, aboveground biomass and C ac

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16

Taksande, A., A. Jadhav, and J. Vagha. "Comparison Between Automated and Manual Sphygmomanometer for Measuring Blood Pressure in Children." Journal of Nepal Paediatric Society 35, no. 1 (2015): 13–17. http://dx.doi.org/10.3126/jnps.v35i1.11568.

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Introduction: The mercury sphygmomanometer has been the gold standard used for obtaining blood pressure (BP). However, due to environmental concerns and more use of automated BP devices, an alternative to using the standard mercury sphygmomanometer to measure BP. The aim of this study is to evaluate the accuracy of the Automated (Omron) BP device against the mercury sphygmomanometer in children.Material and Methods: One hundred children were enrolled in this study. The accuracy of Omron HEM–7121 BP readings was compared with that of mercury BP device readings. Each children had four BP measure

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17

Chawla, Garima, Baljeet Maini, and Anand Kumar Bhardwaj. "Relationship Between Non-Invasive Blood Pressure (NIBP), on First Day of Life with Birth Weight." Journal of Nepal Paediatric Society 35, no. 2 (2016): 141–47. http://dx.doi.org/10.3126/jnps.v35i2.12911.

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Introduction: India faces lot of neonatal morbidity. Non-invasive blood pressure (NIBP) monitoring is being used for monitoring sick new borns as a safe and cost effective method of blood pressure monitoring. But there is no available information on normal values of NIBP for neonates in India. With more stress of government (and advancement) in new born care, establishing normative data of NIBP in Indian newborns should be high priority. Material and Methods: This was an observational cohort study done in a level III neonatal intensive care unit. 164 clinically stable babies on day 1 of life w

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18

Qin, Yuanli, Fugui Zhang, Shandong Xue, Tao Ma, and Linsong Yu. "Heavy Metal Pollution and Source Contributions in Agricultural Soils Developed from Karst Landform in the Southwestern Region of China." Toxics 10, no. 10 (2022): 568. http://dx.doi.org/10.3390/toxics10100568.

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Heavy metal pollution of soil in agricultural areas is the most prominent environmental pollution problem in China, seriously affecting human health and food security. It has become one of the environmental problems to which all sectors of society attach great importance. Soil heavy metals in the weathering area of hazardous geological bodies in southwest China have naturally high background attributes. Therefore, ecological risk assessment and analysis of potential sources of soil heavy metals in southwest China is of great significance for soil health management, soil heavy metal pollution c

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Magnussen, Olaf M. "(Invited) Atomic-Scale Aspects of Nucleation and Growth at Liquid-Liquid Interfaces." ECS Meeting Abstracts MA2022-01, no. 23 (2022): 1152. http://dx.doi.org/10.1149/ma2022-01231152mtgabs.

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Interfaces between liquid metals and liquid electrolytes, in particular the liquid Hg - electrolyte interface, have played a key role in the development of the theory of the electrical double layer and electrochemical adsorption. More recently, liquid-liquid interfaces have regained interest in the field of material synthesis. Unlike solid interfaces, where strain and stress, heterogeneities, and defects strongly influence growth processes, fluid systems provide soft, defect- and stress-free interfaces. In addition, the growth process profits from the high mobility of atoms, molecules, and par

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Lu, Qi, Hongbin Ma, Yao Zhou, Roberto Calvelo-Pereira, and Yan Shen. "Caragana korshinskii Kom. plantation reduced soil aggregate stability and aggregate-associated organic carbon on desert steppe." PeerJ 10 (February 16, 2022): e12507. http://dx.doi.org/10.7717/peerj.12507.

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Background After implementing of the “Grain-for-Green” project, Caragana korshinskii Kom. has been widely planted in China’s arid regions. Although natural restoration grassland and artificial Caragana plantations measures have long been focuses in carbon research, the combined influence of natural restoration grassland and artificial Caragana plantation measures on aggregate stability and the aggregate-associated organic carbon (OC) remains unclear. Method We selected natural grassland (NG) and three different densities of Caragana plantations (high planting density, HG; middle planting densi

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Valent, Jason, Jeffrey A. Zonder, Michaela Liedtke, et al. "Safety and Tolerability of Cael-101 in Combination with Anti-Plasma Cell Dyscrasia Therapy in Patients with AL Amyloidosis: 1-Year Results from an Open-Label Phase 2 Trial." Blood 138, Supplement 1 (2021): 468. http://dx.doi.org/10.1182/blood-2021-153636.

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Abstract Background: AL amyloidosis, a rare, severe, progressive, systemic disorder caused by plasma cell dyscrasia (PCD), results in insoluble immunoglobulin light chain amyloid fibrils depositing in organs and causing significant dysfunction, morbidity, and mortality. Most patients receive anti-PCD therapy as standard of care (SOC) to suppress plasma cell proliferation and arrest the generation and deposition of new amyloid fibrils. At present, no approved therapies exist that target fibrils already deposited. CAEL-101, a monoclonal antibody, binds to amyloid light chain fibrils and promotes

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Castillo, Ezer, and Nikolay Dimitrov. "Electrodeposition of Cu-Zn and Cu-Mn Films As Precursors for Nanoporous Copper Synthesis." ECS Meeting Abstracts MA2022-01, no. 22 (2022): 1118. http://dx.doi.org/10.1149/ma2022-01221118mtgabs.

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An all-electrochemical approach for the synthesis of fine-structured nanoporous copper (np-Cu) films has been developed which involves the initial electrodeposition of Cu-containing alloys followed by a selective dissolution or dealloying of the less noble metal via anodization. This process leaves a nanoporous, three-dimensional spongy structure. Among these alloys are Cu-Zn and Cu-Mn that are commonly used as protective and decorative coatings. These types of coatings are typically rich in Cu; however, precursor alloys for dealloying purposes must contain high atomic percentages (at%) of the

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23

Qu, Rui, Guilin Han, Man Liu, Kunhua Yang, Xiaoqiang Li, and Jinke Liu. "Fe, Rather Than Soil Organic Matter, as a Controlling Factor of Hg Distribution in Subsurface Forest Soil in an Iron Mining Area." International Journal of Environmental Research and Public Health 17, no. 1 (2020): 359. http://dx.doi.org/10.3390/ijerph17010359.

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To identify whether the iron (Fe) mining area in the Jiulongjiang River basin (JRB) has an influence on the mercury in the forest soil, the spatial distribution patterns of mercury’s behavior on different controlling factors were analyzed, and a potential ecological risk assessment was done. A total of 107 soil samples were collected from two forest soil profiles, one profile near the Fe mining area and the other far from it. The soil near the mining area had a moderate potential ecological risk with high Fe content rich in the upper layer of soil (<70 cm), whereas soil collected far from t

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Munson, Paul, Juraj Adamik, and Lisa Butterfield. "829 Tumor alpha-fetoprotein inhibits cholesterol and steroid metabolism in monocyte-derived dendritic cells." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A880—A881. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0829.

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BackgroundHepatocellular carcinoma (HCC) is a particularly lethal malignancy in part due to the potently immune-suppressive tumor microenvironment. The weak immune response is due in part to the presence of tumor alpha-fetoprotein (tAFP), a fetal glycoprotein that is produced by a majority of HCC tumors.1 Previously, we showed that tAFP potently inhibited the differentiation of monocytes to dendritic cells when compared to cord blood-derived normal AFP (nAFP) and ovalbumin (OVA).2 Additionally, we demonstrated that tAFP inhibits lipid metabolism by limiting the expression of fatty acid metabol

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O'Sullivan, Eugene J. "(Invited) Electrochemistry: Adventures in Metallization." ECS Meeting Abstracts MA2022-02, no. 30 (2022): 1081. http://dx.doi.org/10.1149/ma2022-02301081mtgabs.

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Microelectronics has benefited enormously from electrochemistry, particularly in metallization. Metallizing through-holes in multilevel printed circuit boards was a major, successful application of electroless Cu (1). Electroless Co-based magnetic films deposited on non-magnetic electroless nickel films on rigid aluminum disks propelled the magnetic storage industry for years. A decade or more ago, it looked as if electroless Co(W)(P) was the ideal candidate to replace PVD Ta-based liners for CMOS back-end-of-line (BEOL) builds (2). Its cost undid it, however, despite meeting selectivity, diff

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Tocci, Piera, Celia Roman, Rosanna Sestito, et al. "Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition." Cell Death & Disease 14, no. 1 (2023). http://dx.doi.org/10.1038/s41419-022-05538-6.

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AbstractPARP inhibitors (PARPi) have changed the treatment paradigm of high-grade serous ovarian cancer (HG-SOC). However, the impact of this class of inhibitors in HG-SOC patients with a high rate of TP53 mutations is limited, highlighting the need to develop combinatorial therapeutic strategies to improve responses to PARPi. Here, we unveil how the endothelin-1/ET-1 receptor (ET-1/ET-1R) axis, which is overexpressed in human HG-SOC and associated with poor prognosis, instructs HG-SOC/tumor microenvironment (TME) communication via key pro-malignant factors and restricts the DNA damage respons

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Sestito, Rosanna, Piera Tocci, Celia Roman, Valeriana Di Castro, and Anna Bagnato. "Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer." Journal of Experimental & Clinical Cancer Research 41, no. 1 (2022). http://dx.doi.org/10.1186/s13046-022-02317-1.

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Abstract Background Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous ovarian carcinoma (HG-SOC), endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling promotes EMT driving tumor progression. However, the complex nature of intertwined regulatory circuits activated by ET-1 to trigger the metastatic process is not fully elucidated. Methods The capacity of ET-1 pathway to guide a critical transcriptional network that is instrumental for metastatic growth was identified in patient-derived

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Masi, Ilenia, Flavia Ottavi, Danila Del Rio та ін. "The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer". Cell Death & Disease 14, № 1 (2023). http://dx.doi.org/10.1038/s41419-023-05612-7.

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AbstractDissemination of high-grade serous ovarian cancer (HG-SOC) in the omentum and intercalation into a mesothelial cell (MC) monolayer depends on functional α5β1 integrin (Intα5β1) activity. Although the binding of Intα5β1 to fibronectin drives these processes, other molecular mechanisms linked to integrin inside-out signaling might support metastatic dissemination. Here, we report a novel interactive signaling that contributes to Intα5β1 activation and accelerates tumor cells toward invasive disease, involving the protein β-arrestin1 (β-arr1) and the activation of the endothelin A recepto

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Sharma, Sunil, Henrik Fox, Francisco Aguilar, et al. "Auto positive airway pressure therapy reduces pulmonary pressures in adults admitted for acute heart failure with pulmonary hypertension and obstructive sleep apnea. The ASAP-HF Pilot Trial." Sleep 42, no. 7 (2019). http://dx.doi.org/10.1093/sleep/zsz100.

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AbstractObjectivesPulmonary hypertension (PH) is extremely common in acute decompensated heart failure (ADHF) patients and predicts increased mortality. Obstructive sleep apnea (OSA), highly prevalent in congestive heart failure patients, may contribute to further elevated pulmonary pressures. This study evaluates the impact of positive airway pressure (PAP) therapy on PH in patients admitted for ADHF with OSA.MethodsA two-center randomized control trial comparing standard of care (SOC) therapy for ADHF versus addition of PAP therapy in patients with concomitant OSA.ResultsTwenty-one consecuti

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Gulati, Anil, Rajat Choudhuri, Ajay Gupta, et al. "Abstract 118: Multicentric, Randomized Controlled Phase III Study of Centhaquine (Lyfaquin®) as an Effective First-in-class Resuscitative Agent in Hypovolemic Shock Patients." Circulation 142, Suppl_4 (2020). http://dx.doi.org/10.1161/circ.142.suppl_4.118.

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Background: Centhaquine (CQ) is a novel, first-in-class resuscitative agent for the treatment of hypovolemic shock. Methods: Efficacy of CQ for the treatment of hypovolemic shock as an adjuvant to standard of care (SOC) was evaluated in a prospective, multi-center, randomized, double-blind, placebo-controlled Phase 3 study. Key inclusion criteria were; systolic blood pressure of <90 mm Hg, blood lactate levels of > 2 mmol/L and patients receiving SOC in a hospital or ICU setting. Patients were randomized in a 2:1 ratio either to the CQ group receiving CQ dose of 0.01 mg/kg by IV infusion

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Bainey, Kevin R., Yinggan Zheng, Richard Coulden, et al. "Remote ischaemic conditioning in ST elevation myocardial infarction: a registry-based randomised trial." Heart, August 20, 2021, heartjnl—2021–319455. http://dx.doi.org/10.1136/heartjnl-2021-319455.

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ObjectivesRemote ischaemic conditioning (RIC) has been tested as a possible strategy for mitigating reperfusion injury in ST elevation myocardial infarction (STEMI) with primary percutaneous coronary intervention (PPCI). However, surrogate outcomes have shown inconsistent effects with lack of clinical correlation.MethodsWe performed a registry-based randomised study of patients with STEMI allocated to RIC (4 cycles of blood pressure cuff inflation to 200 mm Hg for 5 min of ischaemia followed by 5 min of reperfusion) or standard of care (SOC) during PPCI. We examined the associations of RIC on

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Tan, Jiahong, Xu Zheng, Mengchen Li та ін. "C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer". Oncogene, 8 травня 2021. http://dx.doi.org/10.1038/s41388-021-01788-4.

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AbstractPARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency in HR-proficient cancers. Here, we found that the expression of CCAAT/enhancer-binding protein β (C/EBPβ), a transcription factor, was inversely correlated with PARPi sensitivity in vitro and in vivo, both in HR-proficient condition. High C/EBPβ expression enhanced PARPi tolerance; PARPi treatment in turn induced C/EBPβ expression. C/EBPβ directly targeted and upregulated multiple HR genes (BRCA1, BRIP1,

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Samimagham, Hamid Reza, Mehdi Hassani Azad, Dariush Hooshyar, Maryam Haddad, Mohsen Arabi, and Mitra KazemiJahromi. "Evaluation of the efficacy and safety of recombinant erythropoietin on the improvement of hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial." Trials 22, no. 1 (2021). http://dx.doi.org/10.1186/s13063-021-05363-w.

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Abstract Objectives To evaluate the effect of recombinant erythropoietin on hospitalised COVID-19 patients. Trial design Concealed, randomized, single-blinded, phase 2 controlled clinical trial with two arm parallel-group design of 20 patients allocated with 1:1 ratio and using the placebo in the control group. Participants This study will be performed at Shahid Mohammadi Hospital in Bandar Abbas, Hormozgan in Iran. All positive (PCR confirmed) COVID-19 patients ≤65 years old who have Hb≤9 and at least one of the severe COVID-19 symptoms (tachypnea (breathing rate> 30 beats per minute), hyp

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Song, Wen, Huizhong Zhang, Xinju Li, et al. "Safe utilization of cultivated land in high-risk areas of soil heavy metal pollution based on soil resilience." Frontiers in Environmental Science 10 (August 26, 2022). http://dx.doi.org/10.3389/fenvs.2022.889069.

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With global urbanization and industrialization, environmental pollution and food safety problems caused by soil heavy metal pollution occur frequently. To realize the safe utilization of cultivated land resources in high-risk areas of heavy metal pollution, we present an approach to safe utilization classification and management in this study. A typical agricultural area around industrial and mining enterprises located in the economic belt of the Yangtze River Delta was chosen as the research area with cultivated soil as the research object. A total of 1,139 geochemical survey sampling sites a

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Ha, Nguyen Van, Doan Thanh Dat, and Trieu Thi Nguyet. "Stereoelectronic Properties of 1,2,4-Triazole-Derived N-heterocyclic Carbenes - A Theoretical Study." VNU Journal of Science: Natural Sciences and Technology 35, no. 4 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4935.

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A theoretical study on stereo and electronic properties of a series of six 1,2,4-triazole-derived carbenes bearing different N4-substituents, namely isopropyl (1), benzyl (2), phenyl (3), mesityl (4), 2,6-diisopropylphenyl (5) and 1-naphthyl (6), has been carried out. Structures of the six carbenes were first optimized using Gaussian® 16 at B3LYP level. Their molecular geometries and electronic structures of the frontier orbitals were examined. The results suggest the similarity in nature of their HOMOs, which all posses s symmetry with respect to the heterocycle and essentially be the lone el

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Lima, Dijaci Santos de, Maria Alana Neres de Pontes, Francisco Patricio de Andrade Júnior, Bernadete Helena Cavalcanti dos Santos, Wylly Araújo de Oliveira, and Igara Oliveira Lima. "Atividade antibacteriana de citronelal e citronelol contra cepas de Escherichia coli produtoras de ESBL." ARCHIVES OF HEALTH INVESTIGATION 9, no. 3 (2020). http://dx.doi.org/10.21270/archi.v9i3.4745.

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Introdução: A bactéria Escherichia coli é um bacilo Gram negativo que pode causar o desenvolvimento de infecções, principalmente, no trato gastrointestinal, podendo levar os acometidos a óbito. Além disso, houve o surgimento de cepas produtoras de betalactamases de amplo espectro (ESBL), que se caracterizam por apresentarem-se resistentes a diversos β-lactâmicos, sendo necessária a busca por novas substâncias com atividade antibacteriana frente a esses microrganismos. Objetivo: O presente trabalho teve como objetivo estudar a atividade antimicrobiana dos fitoconstituintes citronelal e citronel

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