Relevant bibliographies by topics / HFSH

Academic literature on the topic 'HFSH'

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Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "HFSH"

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Toh, Evelyn, Harry D. Kurtz, and Yves V. Brun. "Characterization of the Caulobacter crescentus Holdfast Polysaccharide Biosynthesis Pathway Reveals Significant Redundancy in the Initiating Glycosyltransferase and Polymerase Steps." Journal of Bacteriology 190, no. 21 (August 29, 2008): 7219–31. http://dx.doi.org/10.1128/jb.01003-08.

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ABSTRACT Caulobacter crescentus cells adhere to surfaces by using an extremely strong polar adhesin called the holdfast. The polysaccharide component of the holdfast is comprised in part of oligomers of N-acetylglucosamine. The genes involved in the export of the holdfast polysaccharide and the anchoring of the holdfast to the cell were previously discovered. In this study, we identified a cluster of polysaccharide biosynthesis genes (hfsEFGH) directly adjacent to the holdfast polysaccharide export genes. Sequence analysis indicated that these genes are involved in the biosynthesis of the minimum repeat unit of the holdfast polysaccharide. HfsE is predicted to be a UDP-sugar lipid-carrier transferase, the glycosyltransferase that catalyzes the first step in polysaccharide biosynthesis. HfsF is predicted to be a flippase, HfsG is a glycosyltransferase, and HfsH is similar to a polysaccharide (chitin) deacetylase. In-frame hfsG and hfsH deletion mutants resulted in severe deficiencies both in surface adhesion and in binding to the holdfast-specific lectin wheat germ agglutinin. In contrast, hfsE and hfsF mutants exhibited nearly wild-type levels of adhesion and holdfast synthesis. We identified three paralogs to hfsE, two of which are redundant to hfsE for holdfast synthesis. We also identified a redundant paralog to the hfsC gene, encoding the putative polysaccharide polymerase, and present evidence that the hfsE and hfsC paralogs, together with the hfs genes, are absolutely required for proper holdfast synthesis.
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Donadeu, Francesc Xavier, and Mario Ascoli. "The Differential Effects of the Gonadotropin Receptors on Aromatase Expression in Primary Cultures of Immature Rat Granulosa Cells Are Highly Dependent on the Density of Receptors Expressed and the Activation of the Inositol Phosphate Cascade." Endocrinology 146, no. 9 (September 1, 2005): 3907–16. http://dx.doi.org/10.1210/en.2005-0403.

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Abstract Signaling pathways mediating the divergent effects of FSH and LH on aromatase in immature rat granulosa cells were studied by infecting cells with increasing amounts of adenoviral vectors for the human LH receptor (hLHR) or FSH receptor (hFSHR). Increasing amounts of Ad-hLHR, used at a multiplicity of infection (MOI) of 20 or 200 viable viral particles/cell, increased human chorionic gonadotropin (hCG) binding and hCG-induced cAMP and Akt phosphorylation, but inositol phosphates only increased in response to hCG in cells infected with 200 MOI Ad-hLHR. In contrast, hCG increased aromatase expression in cells infected with 20, but not in cells infected with 200, MOI Ad-hLHR. Cells infected with 20 or 200 MOI Ad-hFSHR showed increased hFSH binding and hFSH-induced Akt phosphorylation, but the hFSH-induced cAMP response was unchanged relative to control cells. However, hFSH was able to stimulate the inositol phosphate cascade in the Ad-hFSHR-infected cells, and the hFSH induction of aromatase was abolished. We also found that activation of C kinase or expression of a constitutively active form of Gαq inhibited the induction of aromatase by hFSH or 8Br-cAMP. We conclude that the differential effects of FSH and LH on aromatase in immature granulosa cells are highly dependent on gonadotropin receptor density and on the signaling pathways activated. We propose that aromatase is induced by common signals generated by activation of the FSHR and LHR (possibly cAMP and Akt) and that the activation of the inositol phosphate cascade in cells expressing a high density of LHR or FSHR antagonizes this induction.
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Kene, PS, VC Nalavadi, RR Dighe, KS Iyer, and SD Mahale. "Identification of the structural and functional determinants of the extracellular domain of the human follicle stimulating hormone receptor." Journal of Endocrinology 182, no. 3 (September 1, 2004): 501–8. http://dx.doi.org/10.1677/joe.0.1820501.

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The extracellular domain (ECD) of the human follicle-stimulating hormone receptor (hFSHR) is believed to be the major determinant of hormone selectivity. Different discrete, discontinuous regions on the ECD of the hFSHR have been suggested to be crucial for hormone binding. However, the role of the ECD in signal transduction is not well understood. This study provides some insight into these aspects of the structure-function relationship of the ECD of hFSHR. Ten peptides were selected from the ECD on the basis of their ability to be surface oriented, synthesized by the solid-phase method using fluorenylmethyloxycarbonyl chemistry, purified and characterized. They were further studied for their ability to modulate both human follicle-stimulating hormone (hFSH)-FSHR binding and cAMP generation. Competitive inhibition studies showed that, of all the peptides studied, peptides 285-300 and 297-310 hFSHR were able to inhibit hFSH binding to FSHR. Both peptides function as weak competitive inhibitors of hFSH-FSHR binding. Peptides 285-300 hFSHR, 216-235 hFSHR, 184-195 hFSHR, 79-89 hFSHR and 15-31 hFSHR were observed to inhibit FSH-induced cAMP production. In summary, this study suggests that discrete, functional domains of the ECD have a role in hormone binding and signal transduction. Region 285-300 has been identified as a novel region crucial for both FSH binding and cAMP generation.
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Grasso, P., and L. E. Reichert. "Evidence that a calmodulin-like calcium-binding domain of the FSH β-subunit is involved in FSH-induced calcium uptake by Sertoli cells." Journal of Molecular Endocrinology 13, no. 2 (October 1994): 149–55. http://dx.doi.org/10.1677/jme.0.0130149.

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ABSTRACT We have previously shown that a synthetic peptide amide corresponding to residues 1–15 of the human FSH β-subunit (hFSH-β-(1–15)) possesses structural characteristics and calcium-binding properties similar to the calcium-binding loops of calmodulin (CaM). The calcium-binding property of hFSH-β-(1–15) correlated well with its ability to stimulate uptake of calcium (as45 Ca2+) by cultured rat Sertoli cells and proteoliposomes enriched with bovine calf testis FSH receptors. A sequence found in the calcium-binding loops of CaM and a number of other calcium-binding proteins can be represented by the motif +−+−+−+−+−−+, where + represents a calcium-binding residue and − represents a non-binding residue. A sequence containing a similar motif appears in hFSHβ-(1–15) between residues 4 and 15: +−++−+−−−+−+. Using a synthetic peptide strategy, we undertook to determine whether the first three residues of hFSH-β-(1–15) were required to induce uptake of calcium by cultured rat Sertoli cells and FSH receptor-enriched proteoliposomes, and to assess whether rearrangement of the putative calcium-binding ligands (+) of hFSH-β-(1–15) to correspond to their linear sequence in CaM would enhance the ability of hFSH-β-(1–15) to induce calcium uptake in these two model systems. Our results indicate that (1) the amino terminal tripeptide of hFSH-β-(1–15), NSC, is not required for its effects on calcium influx and (2), although the putative calcium-binding loop of hFSH-β-(1–15) does not strictly adhere to the structural motif present in the calcium-binding loops of CaM, this does not adversely affect the potency of hFSH-β-(1–15) in the systems studied. In addition to providing a structural basis for understanding the affinity of hFSH-β-(1–15) for calcium, these studies suggest that the effects of FSH on calcium flux in Sertoli cells may involve a CaM-like region of its β-subunit.
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Santa-Coloma, Tomás A., John W. Crabb, and Leo E. Reichert. "Serine analogues of hFSH-beta-(33–53) and hFSH-beta-(81–95) inhibit hFSH binding to receptor." Biochemical and Biophysical Research Communications 184, no. 3 (May 1992): 1273–79. http://dx.doi.org/10.1016/s0006-291x(05)80020-8.

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Vischer, Henry F., Joke C. M. Granneman, and Jan Bogerd. "Identification of Follicle-Stimulating Hormone-Selective β-Strands in the N-Terminal Hormone-Binding Exodomain of Human Gonadotropin Receptors." Molecular Endocrinology 20, no. 8 (August 1, 2006): 1880–93. http://dx.doi.org/10.1210/me.2005-0202.

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Abstract Glycoprotein hormone receptors contain large N-terminal extracellular domains (ECDs) that distinguish these receptors from most other G protein-coupled receptors. Each glycoprotein hormone receptor ECD consists of a curved leucine-rich repeat domain flanked by N- and C-terminal cysteine-rich regions. Selectivity of the different glycoprotein hormone receptors for their cognate hormones is exclusively determined by their ECDs and, in particular, their leucine-rich repeat domain. To identify human (h)FSH-selective determinants we used a gain-of-function mutagenesis strategy in which β-strands of the hLH receptor (hLH-R) were substituted with their hFSH receptor (hFSH-R) counterparts. Introduction of hFSH-R β-strand 1 into hLH-R conferred responsiveness to hFSH, whereas hLH-R mutants harboring one of the other hFSH-R β-strands displayed none or very limited sensitivity to hFSH. However, combined substitution of hFSH-R β-strand 1 and some of the other hFSH-R β-strands further increased the sensitivity of the mutant hLH-R to hFSH. The apparent contribution of multiple hFSH-R β-strands in providing a selective hormone binding interface corresponds well with their position in relation to hFSH as recently determined in the crystal structure of hFSH in complex with part of the hFSH-R ECD.
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Vischer, Henry F., Joke C. M. Granneman, and Jan Bogerd. "Opposite Contribution of Two Ligand-Selective Determinants in the N-Terminal Hormone-Binding Exodomain of Human Gonadotropin Receptors." Molecular Endocrinology 17, no. 10 (October 1, 2003): 1972–81. http://dx.doi.org/10.1210/me.2003-0172.

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Abstract The nine leucine-rich repeat-containing exodomains of the human FSH receptor (hFSH-R) and the human LH/chorionic gonadotropin receptor (hLH-R) harbor molecular determinants that allow the mutually exclusive binding of human FSH (hFSH) and human LH (hLH)/human chorionic gonadotropin (hCG) when these hormones are present in physiological concentrations. Previously, we have shown that the β-strands of hLH-R leucine-rich repeats 3 and 6 can confer full hCG/hLH responsiveness and binding when simultaneously introduced into a hFSH-R background without affecting the receptor’s responsiveness to hFSH. In the present study, we have determined the nature of contribution of each of these two β-strands in conferring hCG/hLH responsiveness to this mutant hFSH-R. Human LH-R β-strand 3 appeared to function as a positive hCG/hLH determinant by increasing the hCG/hLH responsiveness of the hFSH-R. In contrast, mutagenesis of hFSH-R β-strand 6, rather than the introduction of its corresponding hLH-R β-strand, appeared to allow the interaction of hCG/hLH with the hFSH-R. Hence, hFSH-R β-strand 6 functions as a negative determinant and, as such, restrains binding of hCG/hLH to the hFSH-R. Detailed mutagenic analysis revealed that the ability of the hFSH-R to interact with hCG/hLH depends primarily on the identity of two amino acids (Asn104, a positive LH-R determinant, and Lys179 a negative FSH-R determinant) that are situated on the C-terminal ends of β-strands 3 and 6, respectively.
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Gaillard, O. "L'hormone folliculo-stimulante (hFSH)." Immuno-analyse & Biologie Spécialisée 15, no. 5 (September 2000): 328–33. http://dx.doi.org/10.1016/s0923-2532(00)80055-1.

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Jiang, Chao, Xiaoying Hou, Cheng Wang, Jeffrey V. May, Viktor Y. Butnev, George R. Bousfield, and John S. Davis. "Hypoglycosylated hFSH Has Greater Bioactivity Than Fully Glycosylated Recombinant hFSH in Human Granulosa Cells." Journal of Clinical Endocrinology & Metabolism 100, no. 6 (June 2015): E852—E860. http://dx.doi.org/10.1210/jc.2015-1317.

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Arey, Brian J., Darlene C. Deecher, Emily S. Shen, Panayiotis E. Stevis, Edwin H. Meade, Jay Wrobel, Donald E. Frail, and Francisco J. López. "Identification and Characterization of a Selective, Nonpeptide Follicle-Stimulating Hormone Receptor Antagonist." Endocrinology 143, no. 10 (October 1, 2002): 3822–29. http://dx.doi.org/10.1210/en.2002-220372.

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Abstract The glycoprotein hormones (LH, FSH, and TSH) are critical to the maintenance of physiological homeostasis and control of reproduction. However, despite an obvious utility for synthetic pharmacological agents, there are few reports of selective, nonpeptide agonists or antagonists to receptors for these hormones. We have identified and characterized a novel synthetic molecule capable of inhibiting the action of FSH. This compound, 7-{4-[Bis-(2-carbamoyl-ethyl)-amino]-6-chloro-(1,3,5)-triazin-2-ylamino)-4-hydroxy-3-(4-methoxy-phenylazo)-naphthalene}-2-sulfonic acid, sodium salt (compound 1), is a selective, noncompetitive inhibitor of the human (h) and rat (r) FSH receptors (FSHRs). Compound 1 selectively inhibited binding of [125I]hFSH with an IC50 value of 5.4 ± 2.3 μm. Radioligand-binding assays were performed using the baculovirus expressed extracellular domain of hFSHR (BV-tFSHR) to demonstrate site-specific interaction. Compound 1 competed for [125I]hFSH binding to BV-tFSHR with an IC50 value of 10 ± 2.8 μm. Functionally, compound 1 inhibited hFSH-induced cAMP accumulation and steroidogenesis in vitro with an IC50 value of 3 ± 0.6 μm. Competition of compound 1 for binding to other glycoprotein hormone receptors and other G protein-coupled receptors demonstrated select activity for FHSRs. Compound 1 inhibited ovulation in immature and cycling adult rats. These data provide proof of concept that selective, small molecule antagonists can be designed for glycoprotein hormone receptors.
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Dissertations / Theses on the topic "HFSH"

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Lalanne, Sylvie. "L'hormone folliculostimulante humaine, hFSH : structure, physiopathologie, immunoanalyse." Paris 5, 1990. http://www.theses.fr/1990PA05P208.

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Loureiro, Renan Fernandes. "Caracterização físico-química da foliculotrofina humana (hFSH) recombinante e de suas subunidades, por cromatografia líquida de alta eficiência (HPLC) em fase reversa: comparação com a preparação de referência de hFSH de origem hipofisária do \"National Hormone and Pituitary Program\" dos EUA." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-30032012-100440/.

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Um método de cromatografia líquida de alta eficiência por fase reversa (RP-HPLC) para análise qualitativa e quantitativa do hormônio folículo estimulante humano íntegro (hFSH), foi estabelecido e validado quanto à exatidão, precisão e sensibilidade. O FSH humano é um hormônio glicoprotéico dimérico largamente utilizado em medicina reprodutiva tanto para diagnóstico quanto para terapia. A metodologia desenvolvida preserva a integridade da proteína, permitindo a análise da forma heterodimérica intacta, e não somente de suas subunidades, como é normalmente obtida na maioria das condições geralmente empregadas. Esta técnica foi também utilizada para a comparação da hidrofobicidade relativa de preparações de hFSH hipofisária, urinária e derivadas de células de ovário de hamster chinês (CHO) bem como de outros dois hormônios glicoprotéicos, sintetizados na hipófise anterior: hormônio humano estimulante da tireóide (hTSH) e hormônio luteinizante humano (hLH). O menos hidrofóbico dos três hormônios analisados foi o hFSH, seguido do hTSH e do hLH. Uma diferença significativa (p<0,005) foi observada entre o tempo de retenção (tR) das preparações hipofisária e recombinante de hFSH, refletindo diferenças estruturais nas suas cadeias de carboidratos. Duas isoformas principais foram detectadas no hFSH urinário, incluindo uma forma que foi significativamente diferente (p<0,005) das preparações hipofisária e recombinante. Foram demonstradas linearidade da curva dose-resposta (r=0,9965, n=15) para esta metodologia de RP-HPLC, bem como uma precisão inter-ensaio, cujo coeficiente de variação é menor que 4%, para a quantificação de diferentes preparações de hFSH e uma sensibilidade da ordem de 40 ng. Foram também analisados o comportamento cromatográfico e a hidrofobicidade relativa das subunidades individuais das preparações recombinantes e hipofisária de hFSH. Além disso, a exata massa molecular das subunidades individuais de hFSH e do heterodímero foram simultaneamente determinadas por espectrometria de massa MALDI-TOF. A presente metodologia representa, em nossa opinião, uma ferramenta essencial para a caracterização e controle de qualidade deste hormônio, que ainda não consta das principais farmacopéias.
A reversed-phase high-performance liquid chromatography (RP-HPLC) method for the qualitative and quantitative analysis of intact human follicle-stimulating hormone (hFSH) was established and validated for accuracy, precision and sensitivity. Human FSH is a dimeric glycoprotein hormone widely used as a diagnostic analyte and as therapeutic product in reproductive medicine. The technique developed preserves the protein integrity, allowing the analysis of the intact heterodimeric form rather than just of its subunits, as it is the case for the majority of the conditions currently employed. This methodology has also been employed for comparing the relative hydrophobicity of pituitary, urinary and two Chinese hamster ovary (CHO)-derived hFSH preparations, as well as of two other related glycoprotein hormones of the anterior pituitary: human thyroid-stimulating hormone (hTSH) and human luteinizing hormone (hLH). The least hydrophobic of the three glycohormones analyzed was hFSH, followed by hTSH and hLH. A significant difference (p<0.005) was observed in tR between the pituitary and recombinant hFSH preparations, reflecting structural differences in their carbohydrate moieties. Two main isoforms were detected in urinary hFSH, including a form which was significantly different (p<0.005) for the pituitary and recombinant preparations. The linearity of the dose-response curve (r = 0.9965, n = 15) for this RP-HPLC methodology, as well as an inter-assay precision with relative standard deviation less than 4% for the quantification of different hFSH preparations and a sensitivity of the order of 40 ng, were demonstrated. The chromatographic behavior and relative hydrophobicity of the individual subunits of the pituitary and recombinant preparations were also analyzed. Furthermore, the accurate molecular mass of the individual hFSH subunits and of the heterodimer were simultaneously determined by matrix-assisted laser desorption ionization time-of-flight mass spectral analysis (MALDI-TOF-MS). The present methodology represents, in our opinion, an essential tool for characterization and quality control of this hormone that is not yet described in the main pharmacopoeias.
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LOUREIRO, RENAN F. "Caracterização físico-química da foliculotrofina humana (hFSH) recombinante e de suas subunidades, por cromatografia líquida de alta eficiência (HPLC) em fase reversa: comparação com a preparação de referência de hFSH de origem hipofisária do 'National Hormone and Pituitary Program' dos EUA." reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11467.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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Mageika, Cristiane Moreira de Carvalho. "Preparação e caracterização das subunidades alfa e beta dos hormônios glicoproteicos humanos recombinantes: foliculotrofina, luteotrofina, tereotrofina e sua comparação com os produtos hipofisários." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-10102011-143435/.

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Neste trabalho é descrito um método prático e eficiente para dissociar, em subunidades α e β, quantidades pequenas (da ordem de microgramas) dos hormônios foliculotrofina (hFSH), luteotrofina (hLH) e tireotrofina (hTSH) humana, nativos e recombinantes. A dissociação destes hormônios foi conseguida incubando-os, durante 16 horas, a 37ºC, com diferentes concentrações de ácido acético: 3M, 5M e 0,4M respectivamente para o hFSH, hLH e hTSH. Nestas condições, uma eficiência de dissociação acima de 98% foi obtida. Esta eficiência foi calculada com base nas determinações de massa dos heterodímeros e das subunidades, realizadas por MALDI-TOF-MS. Uma separação rápida e quantitativa das subunidades, com rendimentos da ordem de 80-90%, foi conseguida por cromatografia líquida de alta eficiência em fase reversa (RP-HPLC) em uma coluna C4. As subunidades foram caracterizadas quanto à pureza, hidrofobicidade, massa molecular e distribuição de carga por HPLC de exclusão molecular e fase reversa, SDS-PAGE e focalização isoelétrica. Quando analisadas quanto à hidrofobicidade, as subunidades mostraram-se aproximadamente iguais, enquanto as subunidades β dos três heterodímeros apresentaram a seguinte escala de hidrofobicidade: β-hFSH < β-hTSH < β-hLH. Com relação à massa molecular relativa (Mr), as subunidades α e β do hFSH apresentaram as maiores Mr enquanto as subunidades do hLH as menores. A distribuição dos isômeros de carga das subunidades dos três hormônios ocorreu em uma região ácida, para o hFSH, em uma região básica, para o hLH e em uma região intermediária, para o hTSH. As subunidades α dos três hormônios, quando analisadas via SDS-PAGE, apresentaram praticamente a mesma mobilidade eletroforética, enquanto as subunidades β apresentaram diferentes taxas de migração (mR), sendo mR β-hFSH < mR β-hTSH < mR β-hLH. Diferenças relativas à massa molecular, hidrofobicidade, migração eletroforética e distribuição de carga foram encontradas entre as preparações recombinantes e hipofisárias dos três hormônios. O método descrito é suave, prático e flexível e pode ser adaptado à dissociação de outras glicoproteínas heterodiméricas recombinantes ou nativas. Permite não só estudos e caracterização direta de cada subunidade, como também detectar a presença de subunidades livres em preparações farmacêuticas, que são contaminantes indesejáveis, sendo, portanto, uma ferramenta extremamente útil para o controle de qualidade de produtos farmacêuticos.
In this work a practical and efficient method for the dissociation into α-and β-subunits of small amounts (microgram range) of pituitaryderived and recombinant human follicle-stimulating hormone (hFSH), human luteotropin (hLH) and human thyrotropin (hTSH) is described. Dissociation was achieved by overnight treatment of the glycoproteins, at 37ºC, with acetic acid in different concentrations: 3M, 5M and 0,4M for hFSH, hLH and hTSH respectively. In these conditions, a dissociation efficiency of > 98% was attained. This efficiency was calculated on the basis of relative mass determinations of the heterodimers and subunits carried out via mass spectrometry (MALDI-TOF-MS). The α-and β-subunits were rapidly and quantitatively separated by reversed-phase high-performance liquid chromatography (RP-HPLC) on a C4 column with yields of the order of 80-90%. The isolated subunits were characterized concerning their purity, hidrophobicity, molecular mass and charge distribution, via size exclusion and RP-HPLC, SDS-PAGE and isoelectric focusing. When analyzed with relation to the hydrophobicity, the α-subunits presented approximately the same hydrophobicity, while β-subunits showed the following scale: &beta-hFSH < β-hTSH < β-hLH. Concerning molecular mass, α- and β-subunits of hFSH were shown to have the highest while hLH subunits the lowest. Charge isomers of the subunits of the three glycohormones were predominantly distributed in an acidic region for hFSH, in a basic region for hLH, and in a wider pH range (acidic and basic) for hTSH. Similar migration rates (mR), analyzed via SDS-PAGE, were observed for the α-subunits of the three hormones. A greater variation was found for the β-subunits: mR β-hFSH < mR β-hTSH < mR β-hLH. Differences between recombinant and pituitary preparations of three hormones were observed with relation to molecular mass, hydrophobicity, electrophoretic migration and charge distribution. The described method is mild, practical and flexible and can be adapted to dissociate any recombinant or native heterodimeric glycoprotein, allowing studies and direct characterization of each subunit as well as the detection of free subunits that are undesired contaminants in pharmaceutical preparations, being also an extremely useful tool for the quality control of pharmaceutical products.
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Misztal, David Richard Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Identification of cellular changes associated with increased production of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41326.

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A proteomics approach was used to identify proteins potentially implicated in the cellular response concurrent with elevated production levels of human follicle stimulating hormone in a recombinant Chinese hamster ovary cell line (Darren cells), using zinc and sodium butyrate in the production media to increase expression. To this end, 2-dimensional gel electrophoresis (2-DGE) was utilized. Firstly, several aspects of 2-DGE were developed for this investigation. Gel drying conditions were optimized, and a glycine-free blotting method is described which achieved greater efficiency in rapid transfer of proteins than those previously described. Next, hFSH expression was characterized in Darren cells. An ELISA developed for this investigation examined intracellular (expression) and extracellular (secretion) of hFSH during increased expression. These results show a disproportionate increase in intracellular hFSH (188%) expression above extracellular hFSH (41%).
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Ware, Scott. "HFS Plus File System Exposition and Forensics." Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5559.

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The Macintosh Hierarchical File System Plus, HFS+, or as it is commonly referred to as the Mac Operating System, OS, Extended, was introduced in 1998 with Mac OS X 8.1. HFS+ is an update to HFS, Mac OS Standard format that offers more efficient use of disk space, implements international friendly file names, future support for named forks, and facilitates booting on non-Mac OS operating systems through different partition schemes. The HFS+ file system is efficient, yet, complex. It makes use of B-trees to implement key data structures for maintaining meta-data about folders, files, and data. The implementation of what happens within HFS+ at volume format, or when folders, files, and data are created, moved, or deleted is largely a mystery to those who are not programmers. The vast majority of information on this subject is relegated to documentation in books, papers, and online content that direct the reader to C code, libraries, and include files. If one can't interpret the complex C or Perl code implementations the opportunity to understand the workflow within HFS+ is less than adequate to develop a basic understanding of the internals and how they work. The basic concepts learned from this research will facilitate a better understanding of the HFS+ file system and journal as changes resulting from the adding and deleting files or folders are applied in a controlled, easy to follow, process. The primary tool used to examine the file system changes is a proprietary command line interface, CLI, tool called fileXray. This tool is actually a custom implementation of the HFS+ file system that has the ability to examine file system, meta-data, and data level information that isn't available in other tools. We will also use Apple's command line interface tool, Terminal, the WinHex graphical user interface, GUI, editor, The Sleuth Kit command line tools and DiffFork 1.1.9 help to document and illustrate the file system changes. The processes used to document the pristine and changed versions of the file system, with each experiment, are very similar such that the output files are identical with the exception of the actual change. Keeping the processes the same enables baseline comparisons using a diff tool like DiffFork. Side by side and line by line comparisons of the allocation, extents overflow, catalog, and attributes files will help identify where the changes occurred. The target device in this experiment is a two-gigabyte Universal Serial Bus, USB, thumb drive formatted with Global Unit Identifier, GUID, and Partition Table. Where practical, HFS+ special files and data structures will be manually parsed; documented, and illustrated.
ID: 031001395; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Title from PDF title page (viewed May 28, 2013).; Thesis (M.S.)--University of Central Florida, 2012.; Includes bibliographical references (p. 131-132).
M.S.
Masters
Computer Science
Engineering and Computer Science
Digital Forensics
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Malásek, Jan. "Vliv selekce příznaků metodou HFS na shlukovou analýzu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2015. http://www.nusl.cz/ntk/nusl-221271.

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Master´s thesis is focused on cluster analysis. Clustering has its roots in many areas, including data mining, statistics, biology and machine learning. The aim of this thesis is to elaborate a recherche of cluster analysis methods, methods for determining number of clusters and a short survey of feature selection methods for unsupervised learning. The very important part of this thesis is software realization for comparing different cluster analysis methods focused on finding optimal number of clusters and sorting data points into correct classes. The program also consists of feature selection HFS method implementation. Experimental methods validation was processed in Matlab environment. The end of master´s thesis compares success of clustering methods using data with known output classes and assesses contribution of feature selection HFS method for unsupervised learning for quality of cluster analysis.
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Singh, Sachin. "Analysis of microstrip defected ground structure filters on anisotropic substrates using HFSS /." abstract and full text PDF (free order & download UNR users only), 2005. http://0-wwwlib.umi.com.innopac.library.unr.edu/dissertations/fullcit/3209134.

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Thesis (Ph. D.)--University of Nevada, Reno, 2005.
"December 2005." Includes bibliographical references (leaves 213-220). Online version available on the World Wide Web. Library also has microfilm. Ann Arbor, Mich. : ProQuest Information and Learning Company, [2005]. 1 microfilm reel ; 35 mm.
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Costa, Rodrigo Carvalho Souza. "Estudo experimental e numÃrico de uma antena ressoadora dielÃtrica baseada em CaTi1Âx(Nb2=3Li1=3)xO3ÂÂ (CNLTO) e CaTi1Âx(Nb1=2Ln1=2)xO3 (Ln = Bi (CNBTO) e Fe (CNFTO)) para aplicaÃÃes em bluetooth." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2043.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
O progresso da indÃstria de telecomunicaÃÃes depende da fabricaÃÃo em larga escala de circuitos de baixo custo, alto desempenho elÃtrico, confiabilidade e passividade de miniaturizaÃÃo. Estas caracterÃsticas sÃo necessÃrias para garantir que os sinais transmitidos sejam confinados a uma freqÃÃncia bem definida, evitando assim sinais que possam interferir no desempenho satisfatÃrio de sistemas de telecomunicaÃÃes. As cerÃmicas dielÃtricas fornecem vantagens significantes em termos de compactaÃÃo, peso, estabilidade tÃrmica e custos de produÃÃo em dispositivos de micro-ondas, alÃm de possuir uma grande facilidade de integraÃÃo com outros circuitos integrados de microondas. Este trabalho consiste no desenvolvimento e caracterizaÃÃo de um novo tipo de material cerÃmico para ser utilizado como uma antena miniatura para aplicaÃÃes em Bluetooth (2.4 GHz). O trabalho està dividido em trÃs etapas. A primeira consiste em desenvolver um novo material que possua constante dielÃtrica (25 < Âr < 50), um alto fator de qualidade (Q > 5000) e um coeficiente de temperatura da freqÃÃncia de ressonÃncia (Âf ) prÃximo de zero. A segunda consiste em caracterizar o material desenvolvido atravÃs de DifraÃÃo de Raios-X e Espectroscopias Raman, Infra-vermelho e DielÃtrica. A Ãltima etapa consiste em fabricar e simular a antena feita com o material desenvolvido, comparando o desempenho teÃrico com o prÃtico.
The progress of telecommunication industry is highly dependent of the fabrication of low cost, quality factor and smaller size of the individual components for commercial applications. This kind of characteristics are necessary to warranty that the signal have well suited frequency, avoiding the noise interference signals, that could affect the performance of the telecommunication systems. Dielectric ceramics have significant advantages of light weight, low cost, small size, low profile, high radiation eficiency, low production cost and ease of integration with other active or passive microwave integrated circuit. This work will provide a new ceramic material that could be used in a miniature antenna for Bluetooth applications. This work is divided in three stages. The first one is develop a new material with a good dielectric permittivity (25 < Âr < 50), high quality factor (Q > 5000) and low temperature coeficient of resonant frequency (Âf ). The second one characterize the developed material by XDR, Raman, Infrared and dielectric spectroscopy in microwave region. The last one is build and simulate the antenna made with the developed dielectric material.
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Khan, Raja Sheharyar, and Muhammad Ishfaq. "A Compact Microstrip Patch Antenna for LTE Applications." Thesis, Linnéuniversitetet, Institutionen för fysik och elektroteknik (IFE), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-24505.

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A compact multiband antennas for Long Term Evolution (LTE) applications is a challenge. Both the frequencies of new wireless technologies and new frequency bands must be covered. The lower end of the 0.7- 3.5 GHz band is especially difficult to handle for miniaturized terminal devices. A single layer, line-feed rectangular microstrip patch antenna is small enough for the LTE handsets. Our project proposes size reduction and bandwidth enhancement through adapted feeding techniques. By means of slits the return loss and gain can be optimized with the aid of HFSS (High Frequency Structure Simulator).
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Books on the topic "HFSH"

1

Zander, Amy K. Hollow fiber stripping analysis (HFSA) for taste and odor quantification. Denver, CO: AWWA Research Foundation and American Water Works Association, 1996.

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Ilāhī, Mu hammad Āshiq. Tu hfah-yi k havātīn: Al-ma rūf bih, K havātin-i Islām se Rasūlullāh ... kī bāte n ... 2nd ed. Karācī: Maktabah-yi Dārul ulūm, 1985.

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Krieger, Orran. HFS: A flexible file system for shared-memory multiprocessors. 1994.

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Ltd, ICON Group. HFS, INC.: Labor Productivity Benchmarks and International Gap Analysis (Labor Productivity Series). 2nd ed. Icon Group International, Inc., 2000.

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Ltd, ICON Group. HFS, INC.: International Competitive Benchmarks and Financial Gap Analysis (Financial Performance Series). 2nd ed. Icon Group International, Inc., 2000.

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Simon, Inglis, and Football Stadia Advisory Design Council., eds. Digest of stadia criteria: Featuring the requirements of: FIFA, UEFA, FA, Football League, Scottish League, GM Vauxhall Conference, Beazer Homes League, Diadora League and HFS Loans League. London: Football Stadia Advisory Design Council, 1992.

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Book chapters on the topic "HFSH"

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Chotigeat, W., Y. Watanapokasin, S. Mahler, and P. P. Gray. "Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cells." In Cell Culture Engineering IV, 217–21. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0257-5_24.

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Guo, Tianruo, David Tsai, Siwei Bai, Mohit Shivdasani, Madhuvanthi Muralidharan, Liming Li, Socrates Dokos, and Nigel H. Lovell. "Insights from Computational Modelling: Selective Stimulation of Retinal Ganglion Cells." In Brain and Human Body Modeling 2020, 233–47. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45623-8_13.

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AbstractImprovements to the efficacy of retinal neuroprostheses can be achieved by developing more sophisticated neural stimulation strategies to enable selective or differential activation of specific retinal ganglion cells (RGCs). Recent retinal studies have demonstrated the ability to differentially recruit ON and OFF RGCs – the two major information pathways of the retina – using high-frequency electrical stimulation (HFS). However, there remain many unknowns, since this is a relatively unexplored field. For example, can we achieve ON/OFF selectivity over a wide range of stimulus frequencies and amplitudes? Furthermore, existing demonstrations of HFS efficacy in retinal prostheses have been based on epiretinal placement of electrodes. Other clinically popular techniques include subretinal or suprachoroidal placement, where electrodes are located at the photoreceptor layer or in the suprachoroidal space, respectively, and these locations are quite distant from the RGC layer. Would HFS-based differential activation work from these locations? In this chapter, we conducted in silico investigations to explore the generalizability of HFS to differentially active ON and OFF RGCs. Computational models are particularly well suited for these investigations. The electric field can be accurately described by mathematical formulations, and simulated neurons can be “probed” at resolutions well beyond those achievable by today’s state-of-the-art experimental techniques.
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Jones, Mark. "Microwave Cavity Simulation Using Ansys HFSS." In Microwave Cavities and Detectors for Axion Research, 1–7. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-43761-9_1.

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Lindén, Krister, Erik Axelson, Senka Drobac, Sam Hardwick, Juha Kuokkala, Jyrki Niemi, Tommi A. Pirinen, and Miikka Silfverberg. "HFST — A System for Creating NLP Tools." In Systems and Frameworks for Computational Morphology, 53–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40486-3_4.

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Lindén, Krister, Erik Axelson, Sam Hardwick, Tommi A. Pirinen, and Miikka Silfverberg. "HFST—Framework for Compiling and Applying Morphologies." In Systems and Frameworks for Computational Morphology, 67–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23138-4_5.

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Lindén, Krister, Erik Axelson, Senka Drobac, Sam Hardwick, Miikka Silfverberg, and Tommi A. Pirinen. "Using HFST for Creating Computational Linguistic Applications." In Computational Linguistics, 3–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34399-5_1.

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Benabid, A. L., S. Chabardes, E. Seigneuret, V. Fraix, P. Krack, and P. Pollak. "How Could HFS Functionally Inhibit Neuronal Networks?" In Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005, 33–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-32746-2_7.

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Salters, Vincent J. M. "Anhydrous HFSE Depleted Peridotite as a Ubiquitous Mantle Component." In Crust/Mantle Recycling at Convergence Zones, 105–19. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0895-6_12.

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Lindén, Krister, Sam Hardwick, Miikka Silfverberg, and Erik Axelson. "Using HFST—Helsinki Finite-State Technology for Recognizing Semantic Frames." In Systems and Frameworks for Computational Morphology, 124–36. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23980-4_8.

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Cheng, Ming-Ming, Yun Liu, Qibin Hou, Jiawang Bian, Philip Torr, Shi-Min Hu, and Zhuowen Tu. "HFS: Hierarchical Feature Selection for Efficient Image Segmentation." In Computer Vision – ECCV 2016, 867–82. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46487-9_53.

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Conference papers on the topic "HFSH"

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Zhang, Zhihui, and Kanad Ghose. "hFS." In the 2nd ACM SIGOPS/EuroSys European Conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1272996.1273016.

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Krieger, Orran, and Michael Stumm. "HFS." In the fourth workshop. New York, New York, USA: ACM Press, 1996. http://dx.doi.org/10.1145/236017.236041.

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Nakayama, Masashi, Haruo Sato, Yutaka Sugita, Seiji Ito, Masashi Minamide, and Yoshito Kitagawa. "Low Alkaline Cement Used in the Construction of a Gallery in the Horonobe Underground Research Laboratory." In ASME 2010 13th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2010. http://dx.doi.org/10.1115/icem2010-40038.

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In Japan, any high level radioactive waste (HLW) repository is to be constructed at over 300 m depth below surface. Tunnel support is used for safety during the construction and operation, and shotcrete and concrete lining are used as the tunnel support. Concrete is a composite material comprised of aggregate, cement and various admixtures. Low alkaline cement has been developed for the long term stability of the barrier systems whose performance could be negatively affected by highly alkaline conditions arising due to cement used in a repository. Japan Atomic Energy Agency (JAEA) has developed a low alkaline cement, named as HFSC (Highly Fly-ash Contained Silicafume Cement), containing over 60 wt% of silica-fume (SF) and fly-ash (FA). HFSC was used experimentally as the shotcrete material in construction of part of the 140m deep gallery in the Horonobe Underground Research Laboratory (URL). The objective of this experiment was to assess the performance of HFSC shotcrete in terms of mechanics, workability, durability, and so on. HFSC used in this experiment is composed of 40 wt% OPC (Ordinary Portland Cement), 20 wt% SF, and 40 wt% FA. This composition was determined based on mechanical testing of various mixes of the above components. Because of the low OPC content, the strength of HFSC tends to be lower than that of OPC. The total length of tunnel using HFSC shotcrete is about 73 m and about 500 m3 of HFSC was used. The workability of HFSC shotcrete was confirmed in this experimental construction.
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Cendes, Zoltan. "The development of HFSS." In 2016 USNC-URSI Radio Science Meeting (Joint with AP-S Symposium). IEEE, 2016. http://dx.doi.org/10.1109/usnc-ursi.2016.7588501.

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Ruiz, E., L. Walling, Y. Goren, and N. Spayd. "Liner impedance calculations using HFSS." In Computational accelerator physics. AIP, 1993. http://dx.doi.org/10.1063/1.45364.

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Pastorelli, Mario, Antonio Barbuzzi, Damiano Carra, Matteo Dell'Amico, and Pietro Michiardi. "HFSP: Size-based scheduling for Hadoop." In 2013 IEEE International Conference on Big Data. IEEE, 2013. http://dx.doi.org/10.1109/bigdata.2013.6691554.

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Yang, Yu, and Zhang Xi. "Microwave Devices Simulation with Ansoft HFSS." In 2007 8th International Conference on Electronic Measurement and Instruments. IEEE, 2007. http://dx.doi.org/10.1109/icemi.2007.4350705.

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Zhao, Kezhong, and L. E. Rickard Petersson. "Overview of Hybrid Solver in HFSS." In 2018 IEEE International Symposium on Antennas and Propagation & USNC/URSI National Radio Science Meeting. IEEE, 2018. http://dx.doi.org/10.1109/apusncursinrsm.2018.8608281.

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Kanazawa, T., T. Amemiya, A. Ishikawa, V. Upadhyaya, K. Tsuruta, T. Tanaka, and Y. Miyamoto. "Fabrication of thin-film HfS2 FET." In 2015 73rd Annual Device Research Conference (DRC). IEEE, 2015. http://dx.doi.org/10.1109/drc.2015.7175643.

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Blanovsky, Anatoly. "A Neutron Amplifier: Prospects for Reactor-Based Waste Transmutation." In 12th International Conference on Nuclear Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/icone12-49346.

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A design concept and characteristics for an epithermal breeder controlled by variable feedback and external neutron source intensity are presented. By replacing the control rods with neutron sources, we could maintain good power distribution and perform radioactive waste burning in high flux subcritical reactors (HFSR) that have primary system size, power density and cost comparable to a pressurized water reactor (PWR). Another approach for actinide transmutation is a molten salt subcritical reactor proposed by Russian scientists. To increase neutron source intensity the HFSR is divided into two zones: a booster and a blanket with solid and liquid fuels. A neutron gate (absorber and moderator) imposed between two zones permits fast neutrons from the booster to flow to the blanket. Neutrons moving in the reverse direction are moderated and absorbed in the absorber zone. In the HFSR, neptunium-plutonium fuel is circulated in the booster and blanket, and americium-curium in the absorber zone and outer reflector. Use of a liquid actinide fuel permits transport of the delayed-neutron emitters from the blanket to the booster, where they can provide additional neutrons (source-dominated mode) or all the necessary excitation without an external neutron source (self-amplifying mode). With a blanket neutron multiplication gain of 20 and a booster gain of 50, an external neutron source rate of at least 1015 n/s (0.7MW D-T or 2.5MW electron beam power) is needed to control the HFSR that produces 300MWt. Most of the power could be generated in the blanket that burns about 100 kg of actinides a year. The analysis takes into consideration a wide range of HFSR design aspects including the wave model of observed relativistic phenomena, plant seismic diagnostics, fission electric cells (FEC) with a multistage collector (anode) and layered cathode.
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Reports on the topic "HFSH"

1

Wei, Fulu, Ce Wang, Xiangxi Tian, Shuo Li, and Jie Shan. Investigation of Durability and Performance of High Friction Surface Treatment. Purdue University, 2021. http://dx.doi.org/10.5703/1288284317281.

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The Indiana Department of Transportation (INDOT) completed a total of 25 high friction surface treatment (HFST) projects across the state in 2018. This research study attempted to investigate the durability and performance of HFST in terms of its HFST-pavement system integrity and surface friction performance. Laboratory tests were conducted to determine the physical and mechanical properties of epoxy-bauxite mortar. Field inspections were carried out to identify site conditions and common early HFST distresses. Cyclic loading test and finite element method (FEM) analysis were performed to evaluate the bonding strength between HFST and existing pavement, in particular chip seal with different pretreatments such as vacuum sweeping, shotblasting, and scarification milling. Both surface friction and texture tests were undertaken periodically (generally once every 6 months) to evaluate the surface friction performance of HFST. Crash records over a 5-year period, i.e., 3 years before installation and 2 years after installation, were examined to determine the safety performance of HFST, crash modification factor (CMF) in particular. It was found that HFST epoxy-bauxite mortar has a coefficient of thermal expansion (CTE) significantly higher than those of hot mix asphalt (HMA) mixtures and Portland cement concrete (PCC), and good cracking resistance. The most common early HFST distresses in Indiana are reflective cracking, surface wrinkling, aggregate loss, and delamination. Vacuum sweeping is the optimal method for pretreating existing pavements, chip seal in particular. Chip seal in good condition is structurally capable of providing a sound base for HFST. On two-lane highway curves, HFST is capable of reducing the total vehicle crash by 30%, injury crash by 50%, and wet weather crash by 44%, and providing a CMF of 0.584 in Indiana. Great variability may arise in the results of friction tests on horizontal curves by the use of locked wheel skid tester (LWST) due both to the nature of vehicle dynamics and to the operation of test vehicle. Texture testing, however, is capable of providing continuous texture measurements that can be used to calculate a texture height parameter, i.e., mean profile depth (MPD), not only for evaluating friction performance but also implementing quality control (QC) and quality assurance (QA) plans for HFST.
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Kees, Michelle. HomeFront Strong (HFS): Building Resiliency in Military Families. Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ada624122.

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Qureshi, Kristine, and Denise Hopkins-Chadwick. Simulation Learning: PC-Screen Based (PCSB) versus High Fidelity Simulation (HFS). Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada566946.

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