Journal articles: 'HFLTC'

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Kikushige, Yoshikane, Goichi Yoshimoto, Toshihiro Miyamoto, Fumihiko Ishikawa, Hiromi Iwasaki, Mine Harada, and Koichi Akashi. "hFlt3 Expression Marks Long-Term Hematopoietic Stem Cells, but Not the Pathway Common to Granulocyte/Monocyte and Lymphoid Lineages in Human Hematopoiesis." Blood 108, no. 11 (November 16, 2006): 1654. http://dx.doi.org/10.1182/blood.v108.11.1654.1654.

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Abstract Flt3 is a tyrosine kinase receptor, whose signals support proliferation and differentiation of early hematopoietic progenitors in cooperation with other cytokine signals. The concept of myeloid vs. lymphoid commitment in murine hematopoiesis has been challenged based on the analysis of Flt3 expression (Adolfsson et al, Cell, 2006): Long-term murine hematopoietic stem cells (HSCs) with self-renewal activity do not express murine Flt3 (mFlt3), but mFlt3 is upregulated in a fraction of progenitors common to granulocyte/monocyte and lymphoid lineages, suggesting the existence of the 3rd pathway of murine hematolymphoid development. In order to test whether Flt3 expression can delineate such a developmental pathway also in human hematopoiesis, we have analyzed the expression of human Flt3 (hFlt3) in prospectively-purified human stem and progenitors (PNAS 99, 2002) by utilizing 7-color FACS and a highly efficient xenograft systems. Surprisingly, all single human hCD34+hCD38-Thy-1+Lin-long-term HSCs expressed Flt3 at a low level. Purified Flt3lo HSCs can reconstitute NOD-scid/IL2Rγnull newborns (Blood 106, 2005) for a long-term after adoptive transfer of only 100 cells, and generated all hematopoietic cells including GM, megakaryocyte/erythrocyte (MegE), T, B and NK cells, providing formal proof that hFlt3 is expressed in long-term multipotent human HSCs. In the myeloid pathway, hCD34+hCD38+hCD45RA-IL-3RαloLin-CMPs expressed low to negative levels of hFlt3, and hCD34+hCD38+CD45RA-IL-3Rα-Lin-MEPs did not express Flt3. However, in marked contrast to murine progenitors, hCD34+hCD38+hCD45RA+IL-3RαloLin-GMPs uniformly expressed hFlt3 at the highest level. We then separated CMPs into 2 fractions with negative and low level expression of Flt3. In vitro culture in the presence of cytokine cocktail revealed that hFlt3lo CMPs differentiated into hFlt3-CMPs, hFlt3-MEPs and hFlt3hi GMPs, while hFlt3-CMPs mainly generated hFlt3-MEPs in vitro, suggesting that hFlt3lo CMPs is located upstream of the hFlt3-CMP stage that has skewed differentiation potential into the MegE lineage. In vitro differentiation activity of these progenitors was not affected with or without hFlt3 ligand in the culture. hFlt3 ligand, however, appeared to be able to maintain survival of hFlt3-expressing stem and progenitor cells at least in vitro. Thus, in striking contrast to mice, hFlt3 expression is already initiated at the most primitive long-term HSC stage, and is progressively upregulated in accordance with GM lineage differentiation. These data collectively suggest that the role of Flt3 signaling in hematopoietic development might be quite different between human and mouse, and that hFlt3 signaling may especially play a critical role in maintenance of long-term HSCs and in development of GM cells in human hematopoiesis.

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Liu, Huifei, William R. Sukov, and Jae Y. Ro. "The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor." Archives of Pathology & Laboratory Medicine 143, no. 2 (July 6, 2018): 212–21. http://dx.doi.org/10.5858/arpa.2017-0412-ra.

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Context.— Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts, hemosiderotic fibrolipomatous tumor (HFLT), and myxoinflammatory fibroblastic sarcoma (MIFS) are 3 distinct entities of low-grade spindle cell mesenchymal neoplasm. These tumors have similar clinical presentations and partially overlapping but distinctive pathologic features. A recurrent translocation, t(1;10)(p22;q24), has been detected in a subset of PHAT, HFLT, MIFS, and HFLT/MIFS hybrid cases. Translocation t(1;10)(p22;q24) involves transforming growth factor β-receptor 3 (TGFBR3) and meningioma-expressed antigen 5 (MGEA5) genes on chromosomes 1p22 and 10q24, respectively. However, the percentage of translocation in PHAT, HFLT, and MIFS varies significantly among different studies. The relationship among these tumors has been a controversial topic among experts. Objective.— To discuss the diagnostic and functional significance of translocation t(1;10)(p22;q24) TGFBR3/MGEA5 rearrangement in HFLT, PHAT, and MIFS. Data Sources.— PubMed was used for this study. Conclusions.— Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

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Onai, Nobuyuki, Aya Onai, Roxane Tussiwand, Antonio Lanzavecchia, and Markus G. Manz. "Flt3 Receptor Expression Rescues Dendritic Cell Developmental Potential in Megakaryocyte/Erythrocyte Progenitor Cells." Blood 104, no. 11 (November 16, 2004): 2165. http://dx.doi.org/10.1182/blood.v104.11.2165.2165.

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Abstract Flt3/Flt3-ligand has a non-redundant role in dendritic cell (DC) and interferon producing cell (IPC) development from hematopoietic progenitor cells. Flt3-ligand−/− mice display a severe reduction of DCs and IPCs, and both, Flt3-ligand injection and conditional over- expression of Flt3-ligand in mice leads to an increased pool size of both cellular subsets. Furthermore, DC and IPC developmental precursor activity segregates with Flt3+ progenitor populations in mouse bone marrow. We have reported that common myeloid progenitors (CMPs) and their progeny granulocyte/macrophage progenitors (GMPs) as well as common lymphoid progenitors (CLPs) and pro-T cells can give rise to DCs in vitro and in vivo. DC developmental potential was lost, however, once definitive megakaryocyte/erythrocyte or B cell commitment occurs, both steps that are accompanied by loss flt3 receptor expression. To test if DC/IPC developmental potential can be regained, we evaluated the effect of ecotropic expression of human Flt3 in lin−c-kit+Flt3−Thy1.1−IL-7Ra− cells (flt3− progenitors) and in megakaryocyte/erythrocyte progenitors (MEPs). hFlt3 was transduced into purified flt3− progenitors, MEPs, and GMPs using a retrovirus vector carrying both hFlt3 and GFP. The transduction efficiencies were 20~25%. hFlt3-transduced flt3− progenitors gave rise to functional DCs and IPCs, but not control-GFP-transduced flt3− progenitors in vitro. Similarly, hFlt3-transduced MEPs differentiated into functional DCs in Flt3L, SCF, GM-CSF, IL-4, and TNF-a supplemented cultures but not into TER119+ erythroid cells. DC developmental potential of hFlt3-transduced MEPs was comparable to GFP-transduced GMPs. Over expression of hFlt3 in GMPs resulted in augmentation of its DC developmental potential. Interestingly, both hFlt3-tarnsduced MEPs and GMPs preferentially differentiated into IPCs in Flt3L supplemented medium. RT-PCR analysis revealed that enforced Flt3 signaling in MEPs lead to up-regulation of GM- and/or DC-development affiliated genes such as G-CSF receptor, M-CSF receptor, and GM-CSF receptor, PU.1, C/EBPa and STAT3. Furthermore, hFlt3-transduced MEPs gave rise to myeloid colonies (CFU-GM/G/M) but not CFU-Mix colonies in GM-CSF, IL-3, SCF, Flt3L, Tpo, and Epo supplemented methylcellulose medium. These results show that artificial Flt3 signaling in otherwise Flt3− progenitors is sufficient to reestablish DC/IPC differentiation and GM-differentiation programs.

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Hopkins, Mark, Catherine Gibbons, Phillipa Caudwell, John E. Blundell, and Graham Finlayson. "Differing effects of high-fat or high-carbohydrate meals on food hedonics in overweight and obese individuals." British Journal of Nutrition 115, no. 10 (March 22, 2016): 1875–84. http://dx.doi.org/10.1017/s0007114516000775.

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AbstractAlthough the effects of dietary fat and carbohydrate on satiety are well documented, little is known about the impact of these macronutrients on food hedonics. We examined the effects ofad libitumand isoenergetic meals varying in fat and carbohydrate on satiety, energy intake and food hedonics. In all, sixty-five overweight and obese individuals (BMI=30·9 (sd3·8) kg/m2) completed two separate test meal days in a randomised order in which they consumed high-fat/low-carbohydrate (HFLC) or low-fat/high-carbohydrate (LFHC) foods. Satiety was measured using subjective appetite ratings to calculate the satiety quotient. Satiation was assessed by intake atad libitummeals. Hedonic measures of explicit liking (subjective ratings) and implicit wanting (speed of forced choice) for an array of HFLC and LFHC foods were also tested before and after isoenergetic HFLC and LFHC meals. The satiety quotient was greater afterad libitumand isoenergetic meals during the LFHC condition compared with the HFLC condition (P=0·006 andP=0·001, respectively), whereasad libitumenergy intake was lower in the LFHC condition (P<0·001). Importantly, the LFHC meal also reduced explicit liking (P<0·001) and implicit wanting (P=0·011) for HFLC foods compared with the isoenergetic HFLC meal, which failed to suppress the hedonic appeal of subsequent HFLC foods. Therefore, when coupled with increased satiety and lower energy intake, the greater suppression of hedonic appeal for high-fat food seen with LFHC foods provides a further mechanism for why these foods promote better short-term appetite control than HFLC foods.

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Raharjo, Budiono, and Solichul Hadi. "HIGH FLUORESCENT LYMPHOCYTE COUNT EXAMINATION IN DENGUE HEMORRHAGIC PATIENTS WITH SYSMEX XN-1000 HEMATOLOGY ANALYZER." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 25, no. 2 (April 13, 2019): 207. http://dx.doi.org/10.24293/ijcpml.v25i2.1443.

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Sysmex XN-1000 hematology analyzer is an automated 5-part diff analyzer (eosinophils, basophils, neutrophils, lymphocytes, and monocytes). In the calculated area, the type of difference between the Sysmex hematology device and other hematology devices is Immature Granulocyte (IG), Nucleated Red Blood Cell (NRBC), and High Fluorescent Lymphocytes Count (HFLC). The cells calculated in the HFLC area are atypical lymphocytes. In patients with dengue hemorrhagic fever, it is often found atypical lymphocytes called blue plasma lymphocytes. The purpose of this study was to determine the description of HFLC in patients with dengue fever using the hematology analyzer Sysmex XN-1000. A descriptive retrospective study was conducted during April-May 2017. The subjects of the study were adult patients diagnosed with dengue hemorrhagic fever with WHO criteria. Of the 47 samples of Dengue Hemorrhagic Fever (DHF) patients, the average HFLC results were between 2.0-32.3%, which was 11.5%, while the average range of normal HFLC values was between 0.0-1.4% and was 0.3%. In cases of DHF, there is an increase in HFLC. This is likely to be attributed to atypical lymphocyte increase in dengue hemorrhagic fever. Further research with more varied samples still needs to be done.

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Freedman, J. Daniel, Rostislav Novak, Sharon Bratman Morag, Emily Avitan-Hersh, and David Nikomarov. "Bone Involvement in Hyperphosphatemic Familial Tumoral Calcinosis: A New Phenotypic Presentation." Rambam Maimonides Medical Journal 12, no. 3 (July 20, 2012): e0024. http://dx.doi.org/10.5041/rmmj.10445.

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Mutations in FGF23, KL, and GALNT3 have been identified as the cause for the development of hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC typically present in childhood or adolescence with periarticular soft tissue deposits that eventually progress to disrupt normal joint articulation. Mutations in the GALNT3 gene were shown to account for the hyperphosphatemic state in both HFTC and hyperostosis-hyperphosphatemia syndrome (HHS), the latter characterized by bone involvement. We present the case of a patient of a Druze ethnic origin with known HFTC that presented to our department with the first documented case of pathologic fracture occurring secondary to the disease. Our report introduces this new phenotypic presentation, suggests a potential role for prophylactic bone screening, and highlights the need for preconception genetic screening in selected populations.

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Kim, D. Y., SH Z. Lin, F. Weickert, M. Kenzelmann, E. D. Bauer, F. Ronning, J. D. Thompson, and R. Movshovich. "Intertwined orders in heavy-fermion superconductor CeCoIn5." International Journal of Modern Physics B 32, no. 17 (July 9, 2018): 1840019. http://dx.doi.org/10.1142/s0217979218400192.

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We use thermal conductivity to study a unique state in the high field corner of the superconducting phase of CeCoIn5. The spin-density-wave (SDW) magnetic order in this high field low temperature (HFLT) phase requires superconductivity for its very existence, and both magnetism and superconductivity disappear together at superconducting critical field H[Formula: see text]. We measured thermal conductivity of CeCoIn5 in a rotating magnetic field to study the nature of the HFLT phase. Our measurements reveal the presence of an additional order inside the HFLT phase that is intimately intertwined with the superconducting [Formula: see text]-wave and the SDW orders, which we identify as a superconducting [Formula: see text]-wave pair-density-wave (PDW). CeCoIn5 displays a hierarchy of interactions within the HFLT phase, where spin–orbit coupling orients the SDW, which then determines orientation of the secondary PDW component.

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Augustson, Erik, Michael M. Engelgau, Shu Zhang, Ying Cai, Willie Cher, Richun Li, Yuan Jiang, Krystal Lynch, and Julie E. Bromberg. "Text to Quit China: An mHealth Smoking Cessation Trial." American Journal of Health Promotion 31, no. 3 (January 5, 2016): 217–25. http://dx.doi.org/10.4278/ajhp.140812-quan-399.

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Purpose. To assess the feasibility, acceptability, and efficacy of a text message–based smoking cessation intervention in China. Design. Study design was a randomized control trial with a 6-month follow-up assessment of smoking status. Setting. Zhejiang, Heilongjiang, and Shaanxi provinces in China provided the study setting. Subjects. A total of 8000 adult smokers in China who used Nokia Life Tools and participated in phase 2 (smoking education via text message) of the study were included. Intervention. The high-frequency text contact (HFTC) group received one to three messages daily containing smoking cessation advice, encouragement, and health education information. The low-frequency text contact (LFTC) group received one weekly message with smoking health effects information. Measures. Our primary outcome was smoking status at 0, 1, 3, and 6 months after intervention. Secondary outcomes include participant perceptions of the HFTC intervention, and factors associated with smoking cessation among HFTC participants. Analysis. Descriptive and χ2 analyses were conducted to assess smoking status and acceptability. Factors associated with quitting were assessed using multiple logistic regression analyses. Results. Quit rates were high in both the HFTC and LFTC groups (HFTC: 0 month, 27.9%; 1 month, 30.5%; 3 months, 26.7%; and 6 months, 27.7%; LFTC: 0 month, 26.7%; 1 month, 30.4%; 3 months, 28.1%; and 6 months, 27.7%), with no significant difference between the two groups in an intent-to-treat analysis. Attitudes toward the HFTC intervention were largely positive. Conclusion. Our findings suggest that a text message–based smoking cessation intervention can be successfully delivered in China and is acceptable to Chinese smokers, but further research is needed to assess the potential impact of this type of intervention.

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Carrara, Guilherme M. P., Gabriela B. Silva, Lucas S. Faria, Daniela S. Nunes, Vanessa S. Ribeiro, Camila A. Lopes, Maria do Rosário F. Gonçalves-Pires, et al. "IgY antibody and human neurocysticercosis: a novel approach on immunodiagnosis using Taenia crassiceps hydrophobic antigens." Parasitology 147, no. 2 (October 23, 2019): 240–47. http://dx.doi.org/10.1017/s0031182019001446.

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AbstractHuman neurocysticercosis (NCC) is a worldwide neglected disease caused by Taenia solium metacestode and responsible for various complications and neurological disorders. This study aimed to evaluate the use of specific immunoglobulin Y (IgY) produced by laying hens immunized with a hydrophobic fraction of Taenia crassiceps metacestodes (hFTc) in NCC diagnosis. Egg yolk IgY antibodies were fractionated, purified and characterized. Enzyme-linked immunosorbent assay (ELISA) was carried out to evaluate the production kinetics and avidity maturation of anti-hFTc IgY antibodies throughout the IgY obtention process. Antigen recognition tests were carried out by Western blotting and immunofluorescence antibody test using purified and specific anti-hFTc IgY antibodies for detection of parasitic antigens of T. crassiceps and T. solium metacestodes. Sandwich ELISA was performed to detect circulating immune complexes formed by IgG and parasitic antigens in human sera. The results showed high diagnostic values (93.2% sensitivity and 94.3% specificity) for immune complexes detection in human sera with confirmed NCC. In conclusion, specific IgY antibodies produced from immunized hens with hFTc antigens were efficient to detect T. solium immune complexes in human sera, being an innovative and potential tool for NCC immunodiagnosis.

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Adar, Tuba, and Elif Kılıç Delice. "New integrated approaches based on MC-HFLTS for healthcare waste treatment technology selection." Journal of Enterprise Information Management 32, no. 4 (July 3, 2019): 688–711. http://dx.doi.org/10.1108/jeim-10-2018-0235.

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Purpose Selecting the most appropriate healthcare waste treatment technology (HCWTT) is an uncertain and complex decision-making problem because there exist more than one alternative and many conflicting qualitative and quantitative criteria. However, the use of fuzzy and comparative values, instead of specific crisp values, provides more accurate results, so that the alternatives may be evaluated in accordance with hesitant human nature. The purpose of this paper is to select the best HCWTT using a hesitant fuzzy linguistic term set (HFLTS). Design/methodology/approach Five main criteria were identified for HCWTT selection, such as economic, social, environmental, technical and ergonomic criteria. In total, 19 sub-criteria were examined, and the hierarchy of the criteria was formed. The criteria weights were determined using the multi-criteria hesitant fuzzy linguistic term set (MC-HFLTS). The selection processes of incineration (A1), steam sterilization (A2), microwave (A3) and landfill (A4) alternatives were carried out using the multi-attributive ideal-real comparative analysis (MAIRCA) and multi-attributive border approximation area comparison (MABAC) methods. In the comparative analyses, Vise Kriterijumska Optimizacija I Kompromisno Resenje (VIKOR) and technique for order preference by similarity to an ideal solution (TOPSIS) methods were used. Findings The comparison of the results of the MABAC and MAIRCA methods with the results of VIKOR and TOPSIS methods indicated that A2 (steam sterilization) alternative was the best one and produced the same ranking of the technology alternatives (A2 > A3 > A1 > A4). As a result, the study concluded that these methods can be successfully used for HCWTT selection problems. Originality/value To the best of the authors’ knowledge, MC-HFLTS has not been used to select HCWTT in the existing literature. For the first time, MC-HFLTS&MAIRCA and MC-HFLTS&MABAC approaches were used in order to choose the best treatment method for healthcare waste under the effect of multiple conflicting hierarchical criteria. It has been provided that MABAC and MAIRCA select alternative choices by taking into consideration the hierarchical criteria. Unlike other studies, this study also considered ergonomic criteria that are important for people working during the process of using the treatment technology.

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Abu, Mohd Nazri, Suhana Samat, Norathirah Kamarapani, Fuzina Nor Hussein, Wan Iryani Wan Ismail, and Hamzah Fansuri Hassan. "Tinospora crispaAmeliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/985042.

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The antidiabetic properties ofTinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated withT. crispa(HFDTC), and the high fat diet treated with orlistat (HFDO). After sixteen weeks of treatment, blood and organs were harvested for analyses. Results showed thatT. crispasignificantly (p< 0.05) reduced the body weight (41.14 ± 1.40%), adiposity index serum levels (4.910 ± 0.80%), aspartate aminotransferase (AST: 161 ± 4.71 U/L), alanine aminotransferase (ALT: 100.95 ± 3.10 U/L), total cholesterol (TC: 18.55 ± 0.26 mmol/L), triglycerides (TG: 3.70 ± 0.11 mmol/L), blood glucose (8.50 ± 0.30 mmo/L), resistin (0.74 ± 0.20 ng/mL), and leptin (17.428 ± 1.50 ng/mL) hormones in HFDTC group. The insulin (1.65 ± 0.07 pg/mL) and C-peptide (136.48 pmol/L) hormones were slightly decreased but within normal range. The histological results showed unharmed and intact liver tissues in HFDTC group. As a conclusion,T. crispaameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet.

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Lee, Su-Jin, Hyung-Jin Shin, and Chan-Gi Park. "Strength and Durability of Hybrid Fiber-Reinforced Latex-Modified Rapid-Set Cement Preplaced Concrete for Emergency Concrete Pavement Repair." Applied Sciences 11, no. 10 (May 18, 2021): 4595. http://dx.doi.org/10.3390/app11104595.

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The benefits of using reinforcing fibers in latex-modified rapid-set cement preplaced concrete for emergency pavement repairs were examined in terms of strength, permeability, and durability as functions of the type of fiber. Single-type fibers, including jute, poly (vinyl alcohol) (PVA), and nylon fibers, as well as hybrid fiber mixtures prepared with two of the aforementioned fibers at a 1:1 weight ratio, were evaluated. Fibers were incorporated into the concrete mixture at 1.2 kg/m3. A vibratory press compactor that simulates roller compaction was used to increase compaction and densification of the resulting pavement repair material. The hybrid fiber-reinforced latex-modified rapid-set cement preplaced concrete (HFLMC) was manufactured to satisfy the criteria for opening traffic, i.e., compressive strength of 21 MPa or higher, and flexural strength of 3.5 MPa or higher after 4 h. Pavement requiring repair was removed and replaced with coarse aggregate. The rapid-set binder, fibers, and latex were then mixed and placed onto the coarse aggregate layer. The repair was considered complete after compaction. The resulting HFLMC satisfied all of the test criteria. Furthermore, concretes made with hybrid fibers were more mechanically sound than those made with a single fiber variety. Hybrid fiber concretes made with PVA and nylon fibers exhibited the best properties for emergency pavement repair. These results indicate that HFLMC is suitable for emergency pavement repair.

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Tian, Jie, Ming Yu Luo, and Meng Yang Chen. "A New Type of Hexagonal Fault-Tolerant Clustering Algorithm." Applied Mechanics and Materials 543-547 (March 2014): 1728–33. http://dx.doi.org/10.4028/www.scientific.net/amm.543-547.1728.

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In view of the problem that present most clustering algorithms are given priority to save energy but ignoring fault tolerance, this paper puts forward a new kind of hexagonal fault-tolerant clustering algorithm (HFTC). By increasing the middle management node, which controls nodes rate of false positives and managements topology within the cluster, this algorithm completes nondestructive substitution between nodes. At the same time, the introduction of backup nodes, it also improves the networks fault tolerance. The simulation experiments show that HFTC can guarantee a high fault tolerance in networks, make the network to send more packets, and prolong the network life effectively.

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Chen, Zhen-Song, Kwai-Sang Chin, Luis Martinez, and Kwok-Leung Tsui. "Customizing Semantics for Individuals With Attitudinal HFLTS Possibility Distributions." IEEE Transactions on Fuzzy Systems 26, no. 6 (December 2018): 3452–66. http://dx.doi.org/10.1109/tfuzz.2018.2833053.

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Chen, Zhen-Song, Kwai-Sang Chin, Neng-Ye Mu, Sheng-Hua Xiong, Jian-Peng Chang, and Yi Yang. "Generating HFLTS possibility distribution with an embedded assessing attitude." Information Sciences 394-395 (July 2017): 141–66. http://dx.doi.org/10.1016/j.ins.2017.02.025.

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Chaieb, Selma, Manel Njima, Nouha Ben Abdeljelil, Ahlem Bellalah, Sarah Chouchane, Abdelfatteh Zakhama, and Adnen Moussa. "Hemosiderotic fibrolipomatous tumor: A poorly known entity." Case Reports in Clinical Pathology 5, no. 1 (June 28, 2018): 23. http://dx.doi.org/10.5430/crcp.v5n1p23.

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Hemosiderotic fibrohistiocytic lipomatous tumor (HFLT) is a rare and supposedly benign fibrolipomatous entity. Clinical and imaging features are not specific. So, histologic, immunohistochemical and molecular analyses are required for diagnosis. The clinic and pathologic aspects of this lesion are diversely reported. Moreover, its reactive or neoplastic origin is still under debate. This lesion should be treated by complete excision. It is mandatory to be aware of its tendency to harbor higher-grade lesions with aggressive outcome. We report a case of HFLT affecting the dorsum of the third right finger in a 52-year-old women, in order to describe histologic patterns of this tumor and to discuss the current literature regarding the etiopathogeny and the cytogenetic features of this rare entity.

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Abdullah, Dahlan, H. Hartono, Kundharu Saddhono, Nuning Kurniasih, Akbar Iskandar, Dian Rianita, Purwarno, et al. "HFLTS-TOPSIS With Pseudo-distance in Determining The Best Lecturers." Journal of Physics: Conference Series 1363 (November 2019): 012073. http://dx.doi.org/10.1088/1742-6596/1363/1/012073.

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Wei, Cuiping, Na Zhao, and Xijin Tang. "A Novel Linguistic Group Decision-Making Model Based on Extended Hesitant Fuzzy Linguistic Term Sets." International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems 23, no. 03 (June 2015): 379–98. http://dx.doi.org/10.1142/s0218488515500166.

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Hesitant fuzzy linguistic term set (HFLTS) is a set with ordered consecutive linguistic terms, and is very useful in addressing the situations where people are hesitant in providing their linguistic assessments. Wang [H. Wang, Extended hesitant fuzzy linguistic term sets and their aggregation in group decision making, International Journal of Computational Intelligence Systems 8(1) (2015) 14–33.] removed the consecutive condition to introduce the notion of extended HFLTS (EHFLTS). The generalized form has wider applications in linguistic group decision-making. By introducing distance measures for EHFLTSs, in this paper we develop a novel multi-criteria group decision making model to deal with hesitant fuzzy linguistic information. The model collects group linguistic information by using EHFLTSs and avoids the possible loss of information. Moreover, it can assess the importance weights of criteria according to their subjective and objective information and rank alternatives based on the rationale of TOPSIS. In order to illustrate the applicability of the proposed algorithm, two examples are given and comparisons are made with the other existing methods.

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Wang, Kai, Ning Zhao, Qiang He, and Jianxin Xu. "A quality analysis method for three-dimensional model in aircraft structural parts design." Advances in Mechanical Engineering 13, no. 3 (March 2021): 168781402110080. http://dx.doi.org/10.1177/16878140211008045.

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To analyze the quality of three-dimensional (3D) model for aircraft structural parts designed by model-based definition (MBD) technology, an approach combining analytic hierarchy process (AHP), hesitant fuzzy linguistic term set (HFLTS), and fuzzy synthetic evaluation is proposed. According to all levels of quality standards and part specification-tree elements, a quality assessment index system is constructed from four sub-models of parts 3D model: design model, process model, tooling model, and test model. In addition, the weight of each index is calculated using the AHP. Then the assessment model is established by using a configurable index system model, HFLTS, fuzzy synthetic evaluation, and assigning uniformly and quantitatively the index system through quality grade division rules of indexes and triangular fuzzy numbers. Finally, a case application is used to illustrate the proposed method. The application of this method can make the quality analysis of parts 3D model more effective, accurate, and efficient. This paper can not only help enterprises identify higher-weight and error-prone design factors, but also guide designers in modeling.

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Peluso, Gabriella, E. Tian, Loreto Abusleme, Takashi Munemasa, Taro Mukaibo, and Kelly G. Ten Hagen. "Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome." Journal of Biological Chemistry 295, no. 5 (December 27, 2019): 1411–25. http://dx.doi.org/10.1074/jbc.ra119.009807.

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The importance of the microbiome in health and its disruption in disease is continuing to be elucidated. However, the multitude of host and environmental factors that influence the microbiome are still largely unknown. Here, we examined UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3)-deficient mice, which serve as a model for the disease hyperphosphatemic familial tumoral calcinosis (HFTC). In HFTC, loss of GALNT3 activity in the bone is thought to lead to altered glycosylation of the phosphate-regulating hormone fibroblast growth factor 23 (FGF23), resulting in hyperphosphatemia and subdermal calcified tumors. However, GALNT3 is expressed in other tissues in addition to bone, suggesting that systemic loss could result in other pathologies. Using semiquantitative real-time PCR, we found that Galnt3 is the major O-glycosyltransferase expressed in the secretory cells of salivary glands. Additionally, 16S rRNA gene sequencing revealed that the loss of Galnt3 resulted in changes in the structure, composition, and stability of the oral microbiome. Moreover, we identified the major secreted salivary mucin, Muc10, as an in vivo substrate of Galnt3. Given that mucins and their O-glycans are known to interact with various microbes, our results suggest that loss of Galnt3 decreases glycosylation of Muc10, which alters the composition and stability of the oral microbiome. Considering that oral findings have been documented in HFTC patients, our study suggests that investigating GALNT3-mediated changes in the oral microbiome may be warranted.

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Xiao, Jichang, Jianfeng Cai, and Xiaodong Wang. "A Hesitant Fuzzy Linguistic Multicriteria Decision-Making Method with Interactive Criteria and Its Application to Renewable Energy Projects Selection." Mathematical Problems in Engineering 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/9634725.

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A variety of multicriteria decision-making (MCDM) methods for renewable energy projects evaluation have been proposed, of which the premise of using these methods is to assume that the criteria are independent of each other. However, it may be difficult or costly to build independent criteria set in some cases because renewable energy planning is to pursue a balance of economic, social, and environmental goals, which makes the existence of interaction among criteria be of great possibility. In this paper, we consider a highly ambiguous decision situation, where the experts are allowed to give the evaluations in the form of hesitant fuzzy linguistic terms set (HFLTS). We build a hesitant fuzzy linguistic decision-making model handling the interaction among criteria from the perspective of distance measure and apply it to renewable energy projects selection. The proposed method can consider more fuzzy factors and deal with the interaction among criteria more approximately. It can reduce the decision pressure and improve the decision-making efficiency because the decision makers are allowed to express their preference in form of HFLTS and a decision criteria set of which the criteria are independent of each other is not necessary.

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Hammoud, Rola, Emanuela Pannia, Chih-Sheng Liao, Ruslan Kubant, Erland Arning, Teodoro Bottiglieri, Zdenka Pausova, and G. Harvey Anderson. "Choline Supplementation Mitigates the Adverse Effects of a High Folic Acid Maternal Diet on Food Intake Regulation in the Offspring." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1806. http://dx.doi.org/10.1093/cdn/nzaa067_033.

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Abstract Objectives Folic acid (FA) intake by many women in North America is exceeding recommendations. We have shown that high maternal FA induces methylation-dependent programming of energy regulation associated with an obesogenic phenotype in adult rat offspring. However, it is unclear if this is a direct effect of high FA or due to an imbalance between FA and other methyl-nutrients (i.e., choline) in the 1-carbon cycle. Unlike FA, choline intake by women is below recommendations and is absent from most prenatal supplements, potentially affecting fetal development. The objective of this study was to examine the mechanisms and effects of choline content in high FA maternal diets on in-utero programming of energy regulation and later-life offspring phenotype. Methods Pregnant Wistar rats were fed an AIN-93 G diet with recommended FA and choline (1X, RFRC, control), or 5X-FA diet with choline at 0.5X-(HFLC), 1X-(HFRC), or 2.5X- (HFHC). In pups at birth, brain and liver 1-carbon metabolites, hypothalamic DNA methyltransferase (DNMT) activity and global DNA methylation (5-mC%) were measured. At weaning, one male pup/dam was fed the control diet and weekly weight-gain and food intake were recorded for 20 weeks. Results Offspring born to dams on the HFLC and HFRC, but not HFHC diet, had higher food intake (P < 0.05) and weight-gain (P < 0.01) than controls. In liver at birth, free choline was lower in HFHC than in HFLC pups, but betaine was unaffected. In contrast, in brains, betaine but not free choline concentrations, directly reflected the maternal choline diets. These results suggest that choline may modulate central food intake pathways via the methyl-donor betaine, warranting further investigation. Hypothalamic DNMT activity was highest (P < 0.05) in HFLC pups but global methylation was not affected. Thus, gene expression by RNA sequencing and gene-specific methylation in the hypothalamus is in progress to elucidate the mechanisms underlying the observed phenotype. Conclusions Increased maternal choline mitigates the high FA diet induced increase in body weight and food intake in the adult offspring and results in tissue-specific changes in 1-carbon metabolism at birth. These findings have potential application to human health, providing support to optimize choline and FA intakes by women of childbearing age. Funding Sources CIHR-INMD.

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Chen, Zhen-Song, Luis Martínez, Kwai-Sang Chin, and Kwok-Leung Tsui. "Two-stage aggregation paradigm for HFLTS possibility distributions: A hierarchical clustering perspective." Expert Systems with Applications 104 (August 2018): 43–66. http://dx.doi.org/10.1016/j.eswa.2018.03.013.

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Xian, Sidong, Hailin Guo, Jiahui Chai, and Wenhua Wan. "Interval probability hesitant fuzzy linguistic analytic hierarchy process and its application in talent selection." Journal of Intelligent & Fuzzy Systems 39, no. 3 (October 7, 2020): 2627–45. http://dx.doi.org/10.3233/jifs-190427.

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Hesitant fuzzy linguistic term set (HFLTS) can handle the qualitative and hesitant information in multiple attribute decision making (MADM) problems which are widely used in various fields. However, the experts’ evaluation of information is not completely reliable in the situation where their own knowledge background is insufficient. In order to deal with deviations due to incomplete reliability of the evaluation, this paper first proposes the interval probability hesitant fuzzy linguistic variable (IPHFLV), which takes the HFLTS as the evaluation part and adds a novel element-reliability of evaluation, thus can describe the different credibility of information evaluation due to the familiarity of experts with schemes and the differences in knowledge cognition. The operation rules and comparison methods are also illustrated. Particularly, under the inspiration of probability theory, we propose the possibility degree of the IPHFLVs. Then we propose IPHFL-AHP based on the AHP and interval probability hesitant fuzzy linguistic variable. Especially, the general geometric consistency index (G-GCI) based on the unbiased estimator of the variance is presented to measure the consistency and the iterative algorithm is constructed to improve the consistency. We use the possibility degree to calculate the priority vector to acquire the total ranking and introduce the process of IPHFL-AHP. Finally, case study of talent selection is given to illustrate the effectiveness and feasibility of the proposed method.

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Ma, Weimin, Wenjing Lei, and Bingzhen Sun. "Three-way group decisions under hesitant fuzzy linguistic environment for green supplier selection." Kybernetes 49, no. 12 (January 13, 2020): 2919–45. http://dx.doi.org/10.1108/k-09-2019-0602.

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Purpose The purpose of this paper is to propose a three-way group decision-making approach to address the selection of green supplier, by extending decision-theoretic rough set (DTRS) into hesitant fuzzy linguistic (HFL) environment, considering the flexible evaluation expression format of HFL term set (HFLTS) and the idea of minimum expected risk in DTRS. Design/methodology/approach Specifically, the authors first present the calculation method of the conditional probability and discuss the loss functions of DTRS with HFL element (HFLE), along with some associated properties being investigated in detail. Further, three-way group decisions rules can be deduced, followed by the cost of every green supplier candidate. Thus, based on these discussions, a novel green supplier selection DTRS model that combines multi-criteria group decision-making (MCGDM) and HFLTS is designed. Findings A numerical example of green supplier selection, the comparative analysis and associated discussions are conducted to illustrate the applicability and novelty of the presented model. Practical implications The selection of green supplier has played a critically strategic role in sustainable enterprise development due to continuous environmental concerns. This paper offers an insight for companies to select green supplier selection from the perspective of three-way group decisions. Originality/value This paper uses three-way decisions to address green supplier selection in the HFL context, which is considered as a MCGDM issue.

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Hafez, Ahmed T., and Mohamed A. Kamel. "Cooperative Task Assignment and Trajectory Planning of Unmanned Systems Via HFLC and PSO." Unmanned Systems 07, no. 02 (April 2019): 65–81. http://dx.doi.org/10.1142/s2301385019500018.

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This paper investigates the problems of cooperative task assignment and trajectory planning for teams of cooperative unmanned aerial vehicles (UAVs). A novel approach of hierarchical fuzzy logic controller (HFLC) and particle swarm optimization (PSO) is proposed. Initially, teams of UAVs are moving in a pre-defined formation covering a specified area. When one or more targets are detected, the teams send a package of information to the ground station (GS) including the target’s degree of threat, degree of importance, and the separating distance between each team and each detected target. Based on the gathered information, the ground station assigns the teams to the targets. HFLC is implemented in the GS to solve the assignment problem ensuring that each team is assigned to a unique target. Next, each team plans its own path by formulating the path planning problem as an optimization problem. The objective in this case is to minimize the time to reach their destination considering the UAVs dynamic constraints and collision avoidance between teams. A hybrid approach of control parametrization and time discretization (CPTD) and PSO is proposed to solve this optimization problem. Finally, numerical simulations demonstrate the effectiveness of the proposed algorithm.

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Kihara, Akio, and Koreaki Ito. "Translocation, Folding, and Stability of the HflKC Complex with Signal Anchor Topogenic Sequences." Journal of Biological Chemistry 273, no. 45 (November 6, 1998): 29770–75. http://dx.doi.org/10.1074/jbc.273.45.29770.

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Morency, Elizabeth, William Laskin, and Xiaoqi Lin. "Cytologic and Histologic Features of Pleomorphic Undifferentiated Sarcoma Arising in a Hybrid Hemosiderotic Fibrolipomatous Tumor and Pleomorphic Hyalinizing Angiectatic Tumor: Report of an Unusual Case with a Literature Review." Acta Cytologica 59, no. 6 (2015): 493–97. http://dx.doi.org/10.1159/000443319.

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Background: Pleomorphic hyalinizing angiectatic tumor (PHAT) and hemosiderotic fibrolipomatous tumor (HFLT) are low-grade neoplasms that share clinicopathologic features and recurring translocation t(1;10)(p22;q24) involving the TGFBR3 and MGEA5 genes. Coexistence of these tumors with a high-grade sarcoma is exceedingly rare and the cytologic features have not been widely described in the literature. Case: A 55-year-old female presented with a soft tissue tumor on the dorsum of the foot. Cytologic smears and corresponding core biopsies were composed of a population of markedly pleomorphic spindle cells seen singly and in loose clusters within a myxofibrous matrix and infiltrating fat, with coarse chromatin, prominent nucleoli, irregular nuclear contours and delicate to vacuolated cytoplasm. Intracytoplasmic hemosiderin granules and rare intranuclear cytoplasmic pseudoinclusions were identified. The histologic features of the excisional biopsy mirrored those of the cytologic preparations, but also demonstrated cellular foci of higher-grade sarcoma composed of markedly pleomorphic tumor cells with large vesicular nuclei and prominent nucleoli, exhibiting a mitotic index of 12 mitotic figures per 10 high-powered fields. Conclusion: While HFLT/PHAT generally can be managed by wide local excision, it is important to be aware of their capacity to harbor higher-grade lesions with metastatic potential which may require more radical surgical excision.

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Kikushige, Yoshikane, Goichi Yoshimoto, Toshihiro Miyamoto, Fumihiko Ishikawa, Hiromi Iwasaki, and Koichi Akashi. "Human FLT3/FLK2 Targets Hematopoietic Stem Cells and Granulocyte/Macrophage Progenitors." Blood 110, no. 11 (November 16, 2007): 1263. http://dx.doi.org/10.1182/blood.v110.11.1263.1263.

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Abstract FLT3/FLK2, a member of the receptor tyrosine kinase family, plays a critical role in maintenance of hematopoietic homeostasis, and the constitutively active form of the FLT3 mutation is one of the most common genetic abnormalities in acute myelogenous leukemia. In murine hematopoiesis, Flt3 is not expressed in self-renewing long-term hematopoietic stem cells (LT-HSCs), but its expression is restricted to the multipotent and the lymphoid progenitor stages at which cells are incapable of self-renewal. In order to test whether Flt3 expression can delineate such a developmental pathway also in human hematopoiesis, we have analyzed the expression of human Flt3 (hFlt3) in prospectively-purified human stem and progenitors (PNAS 2002) by utilizing 7-color FACS and a highly efficient xenograft systems. We have found that Flt3 expression in early hematopoiesis is completely different between human and mice: hCD34+hCD38-hCD90+Lin-LT-HSCs capable of long-term reconstitution in xenogeneic hosts uniformly express hFlt3, and its expression is upregulated through hCD34+hCD38+hCD45RA-hCD123+Lin-common myeloid progenitors (CMPs) to hCD34+hCD38+hCD45RA+hCD123+Lin-granulocyte/macrophage progenitors (GMPs), but hCD34+hCD38+hCD45RA-hCD123-Lin- megakaryocyte/erythrocyte progenitors (MEPs) shut off its expression in human. Furthermore, we have also demonstrated that hFlt3 signaling can prevent stem and progenitors from apoptotic cell death in vitro without any effects on lineage fate decision. Next, we tried to find key molecules for Flt3-Flt3 ligand (FL)-mediating anti-apoptotic effect. First, we tested expression pattern of anti-apoptotic Bcl-2 family genes in HSCs, CMPs, GMPs, MEPs and common lymphoid progenitors (CLPs) in human hematopoiesis. Mcl-1, an indispensable survival factor for murine hematopoiesis (Science, 2005), was also expressed at the highest level in human HSCs, whereas Bcl-2 and Bcl-xL was highly expressed in GMPs and MEPs, respectively. Next, we examined whether FL stimulation can upregulate the expression of Bcl-2 family genes in human purified HSCs and progenitors. FL significantly upregulated the expression of Mcl-1, but not of Bcl-2 or Bcl-xL in HSCs as well as CMPs and GMPs. In conclusion, our data show that the distribution of Flt3 is quite different in mouse and human hematopoeisis. Human Flt3 targets LT-HSCs and myeloid progenitors except for MEPs. Flt3 signaling might support cell survival in early hematopoiesis including the HSC and the myeloid progenitor stages through upregulation of Mcl-1. This is a striking example that the expression pattern of key molecules could be significantly different between human and mouse.

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Liu, Xiaodi, Jianjun Zhu, Shitao Zhang, and Guodong Liu. "Multiple Attribute Group Decision-Making Methods Under Hesitant Fuzzy Linguistic Environment." Journal of Intelligent Systems 26, no. 2 (April 1, 2017): 387–406. http://dx.doi.org/10.1515/jisys-2015-0159.

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AbstractThe aim of this paper is to develop some aggregation operators for multiple-attribute group decision making (MAGDM) with hesitant fuzzy linguistic information. First, the relationship between uncertain linguistic variable and hesitant fuzzy linguistic term set (HFLTS) is discussed. Some operations and aggregation operators for HFLTSs are developed. Second, based on the hesitant fuzzy linguistic weighted arithmetic averaging operator and the hesitant fuzzy linguistic hybrid averaging operator, an approach to MAGDM problem with hesitant fuzzy linguistic information is proposed. Finally, a practical application of the developed approach to supplier selection in a supply chain and a comparative analysis with other methods are presented.

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Sansabas-Villalpando, Verónica, Iván Juan Carlos Pérez-Olguín, Luis Asunción Pérez-Domínguez, Luis Alberto Rodríguez-Picón, and Luis Carlos Mendez-González. "CODAS HFLTS Method to Appraise Organizational Culture of Innovation and Complex Technological Changes Environments." Sustainability 11, no. 24 (December 9, 2019): 7045. http://dx.doi.org/10.3390/su11247045.

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Sustainable development implies establishing principles, objectives and strategies within organizations that impact the organizational culture in innovation. However, a method needs to be defined in order to know the critical factors that allow the strengthening of the organizational culture in innovation with emphasis on Industry 4.0 and sustainable development in a highly changing environment for a specific organization. In this sense, the paper identifies the set of factors that are documented through reviews and analysis of the literature, subsequently proposes a Multi-Criteria Decision Making (MCDM) methodology using hesitant fuzzy linguistic term sets (HFLTS) and combinative distance-based assessment (CODAS), where factors are evaluated to obtain a score and hierarchy value. Weight values were calculated using the ambiguity reduction method, which incorporates the knowledge acquired by researchers in organizational culture of innovation and expert judgment under the Saaty scale used in analytic hierarchy process (AHP). Finally, a model of organizational culture in innovation is proposed that can be used by organizations to focus strategies on the factors of greater hierarchy and thereby optimize their resources considering the sustainable development and the Industry 4.0 approach.

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Wu, Yunna, Mengyao Hu, Mingjuan Liao, Fangtong Liu, and Chuanbo Xu. "Risk assessment of renewable energy-based island microgrid using the HFLTS-cloud model method." Journal of Cleaner Production 284 (February 2021): 125362. http://dx.doi.org/10.1016/j.jclepro.2020.125362.

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Vieira, Alexandre R., Moses Lee, Filippo Vairo, Julio Cesar Loguercio Leite, Maria Cristina Munerato, Fernanda Visioli, Stéphanie Rodrigues D’Ávila, et al. "Root anomalies and dentin dysplasia in autosomal recessive hyperphosphatemic familial tumoral calcinosis (HFTC)." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120, no. 6 (December 2015): e235-e239. http://dx.doi.org/10.1016/j.oooo.2015.05.006.

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Chen, Zhen-Song, Mei Xu, Xian-Jia Wang, Kwai-Sang Chin, Kwok-Leung Tsui, and Luis Martinez. "Individual Semantics Building for HFLTS Possibility Distribution With Applications in Domain-Specific Collaborative Decision Making." IEEE Access 6 (2018): 78803–28. http://dx.doi.org/10.1109/access.2018.2885342.

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Chen, Zhen-Song, Xuan Zhang, Witold Pedrycz, Xian-Jia Wang, Kwai-Sang Chin, and Luis Martínez. "K-means clustering for the aggregation of HFLTS possibility distributions: N-two-stage algorithmic paradigm." Knowledge-Based Systems 227 (September 2021): 107230. http://dx.doi.org/10.1016/j.knosys.2021.107230.

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Saikawa, Naoya, Yoshinori Akiyama, and Koreaki Ito. "FtsH exists as an exceptionally large complex containing HflKC in the plasma membrane of Escherichia coli." Journal of Structural Biology 146, no. 1-2 (April 2004): 123–29. http://dx.doi.org/10.1016/j.jsb.2003.09.020.

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Chavan, R., K. A. Marfatia, I. C. An, D. A. Garber, and M. B. Feinberg. "Expression of CCL20 and Granulocyte-Macrophage Colony-Stimulating Factor, but Not Flt3-L, from Modified Vaccinia Virus Ankara Enhances Antiviral Cellular and Humoral Immune Responses." Journal of Virology 80, no. 15 (August 1, 2006): 7676–87. http://dx.doi.org/10.1128/jvi.02748-05.

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ABSTRACT While modified vaccinia virus Ankara (MVA) is currently in clinical development as a safe vaccine against smallpox and heterologous infectious diseases, its immunogenicity is likely limited due to the inability of the virus to replicate productively in mammalian hosts. In light of recent data demonstrating that vaccinia viruses, including MVA, preferentially infect antigen-presenting cells (APCs) that play crucial roles in generating antiviral immunity, we hypothesized that expression of specific cytokines and chemokines that mediate APC recruitment and activation from recombinant MVA (rMVA) vectors would enhance the immunogenicity of these vectors. To test this hypothesis, we generated rMVAs that express murine granulocyte-macrophage colony-stimulating factor (mGM-CSF), human CCL20/human macrophage inflammatory protein 3α (hCCL20/hMIP-3α), or human fms-like tyrosine kinase 3 ligand (hFlt3-L), factors predicted to increase levels of dendritic cells (DCs), to recruit DCs to sites of immunization, or to promote maturation of DCs in vivo, respectively. These rMVAs also coexpress the well-characterized, immunodominant lymphocytic choriomeningitis virus nucleoprotein (NP) antigen that enabled sensitive and quantitative assessment of antigen-specific CD8+ T-cell responses following immunization of BALB/c mice. Our results demonstrate that immunization of mice with rMVAs expressing mGM-CSF or hCCL20, but not hFlt3-L, results in two- to fourfold increases of cellular immune responses directed against vector-encoded antigens and 6- to 17-fold enhancements of MVA-specific antibody titers, compared to those responses elicited by nonadjuvanted rMVA. Of note, cytokine augmentation of cellular immune responses occurs when rMVAs are given as primary immunizations but not when they are used as booster immunizations, suggesting that these APC-modulating proteins, when used as poxvirus-encoded adjuvants, are more effective at stimulating naïve T-cell responses than in promoting recall of preexisting memory T-cell responses. Our results demonstrate that a strategy to express specific genetic adjuvants from rMVA vectors can be successfully applied to enhance the immunogenicity of MVA-based vaccines.

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Qu, Guohua, Rudan Xue, Tianjiao Li, Weihua Qu, and Zeshui Xu. "A Stochastic Multi-Attribute Method for Measuring Sustainability Performance of a Supplier Based on a Triple Bottom Line Approach in a Dual Hesitant Fuzzy Linguistic Environment." International Journal of Environmental Research and Public Health 17, no. 6 (March 23, 2020): 2138. http://dx.doi.org/10.3390/ijerph17062138.

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China is a developing country and with the speeding up of its industrialization, the environmental problems are becoming more serious, environmental pollution is a major environmental health problem in China. In order to have a more effective management and control of the significant growth issues of environment pollution, green supply chain incentives have started, which is kind of market incentive aiming to moderate the adverse effects of environmental pollution. Proper green chain supply selection and evaluation of companies is becoming very essential in sustainable green supply chain management. Generally speaking, decision-makers (DMs) prefer to provide a set of feasible and quantitative information for making performance evaluation, which motivates us to propose a framework using dual hesitant fuzzy linguistic term set (DHFLTS) and hesitant fuzzy linguistic term set (HFLTS) to select green suppliers. In this paper, group satisfaction and the regret theory are adopted for elicitation of preference information. The DHFLTS and HFLTS provide qualitative preferences of the DMs as well as reflect their hesitancy, inconsistency, and vagueness. Further, two new group satisfaction degrees are defined called the group satisfaction of hesitant fuzzy linguistic term set and dual hesitant fuzzy linguistic term set. Some properties of group satisfaction with DHFLST and HFL are also discussed. Unknown attribute weights are obtained to construct a novel Lagrange function optimization model to maximize the group satisfaction degree, which is an extension of general group satisfaction degree. A novel methodological approach based on two group satisfaction degrees framework and regret theory is developed to rank and select green chain suppliers focusing on specific selection objectives. The proposed model and method of this paper allow the DM to execute different fuzzy scenarios by changing importance weights attached to the triple-bottom-line areas. In the final part, the advantage of the proposed group satisfaction degree under DHFL and HFL background over the existing group satisfaction degree using examples have been presented with different computational combinations.

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Bae, Ju Yong. "Preventive Effects of Different Aerobic Exercise Intensities on the Decline of Cognitive Function in High-Fat Diet-Induced Obese Growing Mice." Medicina 56, no. 7 (July 2, 2020): 331. http://dx.doi.org/10.3390/medicina56070331.

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Background and Objectives: The purpose of this study was to elucidate the effects of different exercise intensities in preventing the decline of cognitive function and lipolysis associated with a high-fat diet-induced obesity in growing mice. Material and Methods: Forty male C57BL/6 mice, aged 4 weeks, were divided into the normal diet (CO, n = 10) and high-fat diet (HF, n = 30) groups to induce obesity for 8 weeks. Subsequently, the HF group was subdivided equally into the HF, HF + low-intensity training (HFLT), and HF + high-intensity training (HFHT) groups, and mice were subjected to treadmill training for 8 weeks. Results: Following the 8-week training intervention, body weight and fat mass were significantly lower in the training groups than in the HF group (p < 0.05). Adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoglyceride lipase levels were significantly higher in the training groups than in the HF group (p < 0.05), and the ATGL and HSL levels were significantly higher in the HFHT group than in the HFLT group (p < 0.05). The Y-maze test showed that the training groups had a higher number of total entries and percent alternation than the HF group (p < 0.05). Hippocampal nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels were significantly higher in the training group than in the HF group (p < 0.05). However, there was no significant difference according to the exercise intensity among the groups. Conclusions: The results of this study suggested that low-intensity exercise is as effective as a high-intensity exercise in preventing the decline of cognitive function and lipolysis, and far more effective in terms of an expected efficiency of workload and prevention of side effects.

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Huang, Han-Chen, and Xiaojun Yang. "Pairwise Comparison and Distance Measure of Hesitant Fuzzy Linguistic Term Sets." Mathematical Problems in Engineering 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/954040.

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A hesitant fuzzy linguistic term set (HFLTS), allowing experts using several possible linguistic terms to assess a qualitative linguistic variable, is very useful to express people’s hesitancy in practical decision-making problems. Up to now, a little research has been done on the comparison and distance measure of HFLTSs. In this paper, we present a comparison method for HFLTSs based on pairwise comparisons of each linguistic term in the two HFLTSs. Then, a distance measure method based on the pairwise comparison matrix of HFLTSs is proposed, and we prove that this distance is equal to the distance of the average values of HFLTSs, which makes the distance measure much more simple. Finally, the pairwise comparison and distance measure methods are utilized to develop two multicriteria decision-making approaches under hesitant fuzzy linguistic environments. The results analysis shows that our methods in this paper are more reasonable.

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Haider, Rana Zeeshan, Najeed Ahmed Khan, Eloisa Urrechaga, and Tahir Sultan Shamsi. "Mature and Immature/Activated Cells Fractionation: Time for a Paradigm Shift in Differential Leucocyte Count Reporting?" Diagnostics 11, no. 6 (May 21, 2021): 922. http://dx.doi.org/10.3390/diagnostics11060922.

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Leucocytes, especially neutrophils featuring pro- and anti-cancerous characteristics, are involved in nearly every stage of tumorigenesis. Phenotypic and functional differences among mature and immature neutrophil fractions are well reported, and their correlation with tumor progression and therapy has emerging implications in modern oncology practices. Technological advancements enabled modern hematology analyzers to generate extended information (research parameters) during complete blood cell count (CBC) analysis. We hypothesized that neutrophil and lymphocyte fractions-related extended differential leucocytes count (DLC) parameters hold superior diagnostic utility over routine modalities. The present study was carried out over a four-and-a-half-year period wherein extended neutrophil (immature granulocyte [IG] and mature neutrophil [NEUT#&]), and lymphocyte (activated/high fluorescence lymphocyte count [HFLC] and resting lymphocyte [LYMP#&]) parameters were challenged over routine neutrophil [NEUT#] and lymphocyte [LYMP#] items in a study population of 1067 hematological neoplasm patients. Extending the classical statistical approaches, machine-learning-backed data visualization was used to explore trends in the study parameters. As a whole, extended neutrophil and lymphocyte count outperformed and was diagnostically more relevant than routine neutrophil and lymphocyte parameters by showing the least difference from their respective (gold-standard) manual DLC counts. The mature neutrophil count was compared to IG, and resting lymphocyte count was compared to HFLC by calling the function ‘correlation’ as a ‘clustering function’ for heatmap based visualization. The aforementioned study parameters displayed close clustering (rearrangement) for their respective study items by presenting distinct trends of equally valuable weights (deviated values), advocating fractions-based extended DLC reporting. Importantly, using a Bland and Altman analysis analogously to a manual neutrophil count, the mature neutrophil count [NEUT#&] remained unbiased since a routine neutrophil count [NEUT#] was found to be a negatively biased. The extended DLC-parameter-driven fractions-based reporting has superior diagnostic utility over classical routine approaches; this finding can largely minimize labor-intensive manual DLC practices, especially in hematology–oncology departments.

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Varajão, Diogo, Rui Esteves Araújo, Luís Miranda, and João Peças Lopes. "EMI Filter Design for a Single-stage Bidirectional and Isolated AC–DC Matrix Converter." Electronics 7, no. 11 (November 12, 2018): 318. http://dx.doi.org/10.3390/electronics7110318.

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This paper describes the design of an electromagnetic interference (EMI) filter for the high-frequency link matrix converter (HFLMC). The proposed method aims to systematize the design process for pre-compliance with CISPR 11 Class B standard in the frequency range 150 kHz to 30 MHz. This approach can be extended to other current source converters which allows time-savings during the project of the filter. Conducted emissions are estimated through extended simulation and take into account the effect of the measurement apparatus. Differential-mode (DM) and common-mode (CM) filtering stages are projected separately and then integrated in a synergistic way in a single PCB to reduce volume and weight. A prototype of the filter was constructed and tested in the laboratory. Experimental results with the characterization of the insertion losses following the CISPR 17 standard are provided. The attenuation capability of the filter was demonstrated in the final part of the paper.

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Pérez-Domínguez, Luis, David Luviano-Cruz, Delia Valles-Rosales, Jésus Hernández Hernández, and Manuel Rodríguez Borbón. "Hesitant Fuzzy Linguistic Term and TOPSIS to Assess Lean Performance." Applied Sciences 9, no. 5 (February 28, 2019): 873. http://dx.doi.org/10.3390/app9050873.

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Manufacturing companies usually expect strategic improvements to focus on reducing both waste and variability in processes, whereas markets demand greater flexibility and low product costs. To deal with this issue, lean manufacturing (LM) emerged as a solution; however, it is often challenging to evaluate its true effect on corporate performance. This challenge can be overcome, nonetheless, by treating it as a multi-criteria problem using the Hesitant Fuzzy linguistic and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method. In fact, the hesitant fuzzy linguistic term sets (HFLTS) is vastly employed in decision-making problems. The main contribution of this work is a method to assess the performance of LM applications in the manufacturing industry using the hesitant fuzzy set and TOPSIS to deal with criteria and attitudes from decision makers regarding such LM applications. At the end of the paper, we present a reasonable study to analyze the obtained results.

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Bandyopadhyay, Kaustav, Pabitra K. Parua, Ajit B. Datta, and Pradeep Parrack. "Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch." BMC Microbiology 11, no. 1 (2011): 34. http://dx.doi.org/10.1186/1471-2180-11-34.

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Kihara, A., Y. Akiyama, and K. Ito. "Host regulation of lysogenic decision in bacteriophage : Transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA)." Proceedings of the National Academy of Sciences 94, no. 11 (May 27, 1997): 5544–49. http://dx.doi.org/10.1073/pnas.94.11.5544.

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Bandyopadhyay, Kaustav, Pabitra Kumar Parua, Ajit Bikram Datta, and Pradeep Parrack. "Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of λCII in vitro." Archives of Biochemistry and Biophysics 501, no. 2 (September 2010): 239–43. http://dx.doi.org/10.1016/j.abb.2010.06.030.

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Cazzato, Gerardo, Anna Colagrande, Antonietta Cimmino, Teresa Lettini, Maria Teresa Savino, Carmen Martella, Giuseppe Ingravallo, and Leonardo Resta. "Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation." Dermatopathology 8, no. 2 (April 4, 2021): 97–102. http://dx.doi.org/10.3390/dermatopathology8020015.

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Pleomorphic hyalinizing angiectatic tumor (PHAT) is a very rare entity of soft tissue considered a “neoplasm of uncertain behaviour of connective or other soft tissue” by the World Health Organization (2020). It develops in subcutaneous tissue of the lower extremities, more frequently in the region of the ankle and foot, and rarely as a deep-seated soft tissue mass in locations such as the perineum, buttock, arms, head and neck, and viscera. Although inconsistent cytogenetic data have been reported on PHAT so far, there are potential morphological and genetic overlaps with hemosiderotic fibrolipomatous tumor (HFLT) and myxoinflammatory fibroblastic sarcoma (MIFS). Here we report a case of PHAT at the level of the upper third of the right thigh in a 48-year-old patient and we also focus on the differential diagnoses of these entities and conduct a literature review of reported cases.

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Nath, Dilip C., Ramesh K. Vishwakarma, and Atanu Bhattacharjee. "A selection modelling approach to analysing missing data of liver Cirrhosis patients." Biometrical Letters 53, no. 2 (December 1, 2016): 83–103. http://dx.doi.org/10.1515/bile-2016-0007.

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AbstractMethods for dealing with missing data in clinical trials have received increased attention from the regulators and practitioners in the pharmaceutical industry over the last few years. Consideration of missing data in a study is important as they can lead to substantial biases and have an impact on overall statistical power. This problem may be caused by patients dropping before completion of the study. The new guidelines of the International Conference on Harmonization place great emphasis on the importance of carefully choosing primary analysis methods based on clearly formulated assumptions regarding the missingness mechanism. The reason for dropout or withdrawal would be either related to the trial (e.g. adverse event, death, unpleasant study procedures, lack of improvement) or unrelated to the trial (e.g. moving away, unrelated disease). We applied selection models on liver cirrhosis patient data to analyse the treatment efficiency comparing the surgery of liver cirrhosis patients with consenting for participation HFLPC (Human Fatal Liver Progenitor Cells) infusion with surgery alone. It was found that comparison between treatment conditions when missing values are ignored potentially leads to biased conclusions.

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Wu, Yunna, and Jianli Zhou. "Risk assessment of urban rooftop distributed PV in energy performance contracting (EPC) projects: An extended HFLTS-DEMATEL fuzzy synthetic evaluation analysis." Sustainable Cities and Society 47 (May 2019): 101524. http://dx.doi.org/10.1016/j.scs.2019.101524.

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Sadikin, Muhammad, Tomonobu Senjyu, and Atsushi Yona. "DC–DC Type High-Frequency Link DC for Improved Power Quality of Cascaded Multilevel Inverter." International Journal of Emerging Electric Power Systems 14, no. 4 (June 28, 2013): 333–40. http://dx.doi.org/10.1515/ijeeps-2012-0007.

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Abstract Multilevel inverters are emerging as a new breed of power converter options for power system applications. Recent advances in power switching devices enabled the suitability of multilevel inverters for high voltage and high power applications because they are connecting several devices in series without the need of component matching. Usually, a transformerless battery energy storage system, based on a cascaded multilevel inverter, is used as a measure for voltage and frequency deviations. System can be reduced in size, weight, and cost of energy storage system. High-frequency link circuit topology is advantageous in realizing compact and light-weight power converters for uninterruptible power supply systems, new energy systems using photovoltaic-cells, fuel-cells and so on. This paper presents a DC–DC type high-frequency link DC (HFLDC) cascaded multilevel inverter. Each converter cell is implemented a control strategy for two H-bridge inverters that are controlled with the same multicarrier pulse width modulation (PWM) technique. The proposed cascaded multilevel inverter generates lower voltage total harmonic distortion (THD) in comparison with conventional cascaded multilevel inverter. Digital simulations are carried out using PSCAD/EMTDC to validate the performance of the proposed cascaded multilevel inverter.

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Journal articles on the topic 'HFLTC'

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