Journal articles: 'Heterogeneous ASIPs'

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Diken, Erkan, Roel Jordans, Rosilde Corvino, Lech Jóźwiak, Henk Corporaal, and Felipe Augusto Chies. "Construction and exploitation of VLIW ASIPs with heterogeneous vector-widths." Microprocessors and Microsystems 38, no. 8 (November 2014): 947–59. http://dx.doi.org/10.1016/j.micpro.2014.05.004.

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Radhakrishnan, S., H. Guo, S. Parameswaran, and A. Ignjatovic. "HMP-ASIPs: heterogeneous multi-pipeline application-specific instruction-set processors." IET Computers & Digital Techniques 3, no. 1 (2009): 94. http://dx.doi.org/10.1049/iet-cdt:20080005.

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Meloni, Paolo, Claudio Rubattu, Giuseppe Tuveri, Danilo Pani, Luigi Raffo, and Francesca Palumbo. "Real-Time neural signal decoding on heterogeneous MPSocs based on VLIW ASIPs." Journal of Systems Architecture 76 (May 2017): 89–101. http://dx.doi.org/10.1016/j.sysarc.2016.11.005.

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Li, Tao, Shuibing He, Ping Chen, Siling Yang, Yanlong Yin, and Cheng Xu. "Application and Storage-Aware Data Placement and Job Scheduling for Hadoop Clusters." Journal of Circuits, Systems and Computers 29, no. 16 (December 21, 2020): 2050254. http://dx.doi.org/10.1142/s0218126620502540.

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As one of the most popular frameworks for large-scale analytics processing, Hadoop is facing two challenges: both applications and storage devices become heterogeneous. However, existing data placement and job scheduling schemes pay little attention to such heterogeneity of either application I/O requirements or I/O device capability, thus can greatly degrade system efficiencies. In this paper, we propose ASPS, an Application and Storage-aware data Placement and job Scheduling approach for Hadoop clusters. The idea is to place application data and schedule application tasks considering both application I/O requirements and storage device characteristics. Specifically, ASPS first introduces novel metrics to quantify I/O requirements of applications. Then, based on the quantification, ASPS places data of different applications to the preferred storage devices. Finally, ASPS tries to launch jobs with high I/O requirements on the nodes with the same type of faster devices to improve system efficiency. We have implemented ASPS in Hadoop framework. Experimental results show that ASPS can reduce the completion time of a single application by up to 36% and the average completion time of six concurrent applications by 27%, compared to existing data placement policies and job scheduling approaches.

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Pasha, Muhammad Adeel, Umer Farooq, and Bilal Siddiqui. "A framework for high-level simulation and optimization of fine-grained reconfigurable architectures." SIMULATION 95, no. 8 (September 10, 2018): 737–51. http://dx.doi.org/10.1177/0037549718796272.

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Field Programmable Gate Arrays (FPGAs), due to their programmability, have become a popular design choice for control and processing blocks of modern-day digital design. However, this flexibility makes them larger, slower, and less power-efficient when compared to Application Specific Integrated Circuits (ASICs). On the other hand, ASICs have their own drawbacks, such as lack of programmability and inflexibility. One potential solution is specialized fine-grained reconfigurable architectures that have improved flexibility over ASICs and better resource utilization than FPGAs. However, designing a fine-grained reconfigurable architecture is a daunting task in itself due to lack of high-level design-flow support. This article proposes an automated design-flow for the system-level simulation, optimization, and resource estimation of generic as well as custom fine-grained reconfigurable architectures. The proposed framework is generic in nature as it can be used for both control-oriented and compute-intensive applications and then generates a homogeneous or heterogeneous reconfigurable architecture for them. Four sets of homogeneous and heterogeneous benchmarks are used in this work to show the efficacy of our proposed design-flow, and simulation results reveal that our framework can generate both generic and custom fine-grained reconfigurable architectures. Moreover, the area and power estimations show that auto-generated domain-specific reconfigurable architectures are 76% and 73% more area and power-efficient, respectively, than generic FPGA-based implementations. These results are consistent with the savings reported for manual designs in the literature.

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Wei, Zhenqi, Peilin Liu, Rongdi Sun, Jun Dai, Zunquan Zhou, Xiangming Geng, and Rendong Ying. "HAVA: Heterogeneous Multicore ASIP for Multichannel Low-Bit-Rate Vocoder Applications." IEEE Transactions on Very Large Scale Integration (VLSI) Systems 24, no. 7 (July 2016): 2593–97. http://dx.doi.org/10.1109/tvlsi.2015.2509459.

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Isaac, Allan Punzalan, Johan Mathew, Anjali Nerlekar, Paul Schalow, and Tamara Sears. "Further thoughts on Asian Studies “inside-out”." International Journal of Asian Studies 18, no. 2 (June 10, 2021): 217–24. http://dx.doi.org/10.1017/s1479591421000152.

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AbstractIn response to Sato and Sonoda's “Asian Studies ‘inside out’: research agenda for the development of Global Asian Studies,” members of the Global Asias Collaborative at Rutgers University – comprised of a diverse group of scholars of Asia and the Asian diaspora located in history, literature, art history, geography, among other disciplines – offer responses to this generative prompt to remap the place and field of “Asia” in its heterogeneous and interwoven temporalities and topologies.

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Dersch, Rick, Ludger Tebartz van Elst, Benedikt Hochstuhl, Bernd L. Fiebich, Oliver Stich, Tilman Robinson, Miriam Matysik, et al. "Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies in the Cerebrospinal Fluid of Patients with Unipolar Depression." Journal of Clinical Medicine 9, no. 8 (July 27, 2020): 2391. http://dx.doi.org/10.3390/jcm9082391.

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Introduction: The risk of developing depression is increased in patients with autoimmune thyroiditis. Autoimmune Hashimoto thyroiditis is diagnosed using the serum markers anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies. In rare cases, patients with autoimmune thyroiditis can also suffer from the heterogeneous and ill-defined syndrome of Hashimoto encephalopathy. Biomarkers for Hashimoto encephalopathy or for any brain involvement of autoimmune thyroiditis are currently lacking. The aim of the present descriptive study was therefore to determine whether a subgroup of seropositive patients shows intrathecal anti-thyroid antibody synthesis in the cerebrospinal fluid (CSF). Participants and methods: Paired serum and CSF samples from 100 patients with unipolar depression were examined for anti-TPO and anti-TG antibodies using enzyme-linked immunosorbent assays. Antibody-specific indices (ASIs) were calculated for seropositive samples. These ASIs allow the differentiation between the brain-derived fraction of antibodies and antibodies which are passively diffused from the serum. ASIs >1.4 were assessed as positive for brain-derived antibodies. Additionally, for explorative evaluations, a stricter ASI limit of >2 was applied. Results: Anti-TPO antibodies were increased in the serum of 16 patients (16%); increased anti-TPO ASIs (>1.4) were detected in 11 of these patients (69%). Anti-TG antibodies in the serum were detected in three patients (3%), with two of them (67%) showing increased ASIs (>1.4). Overall, the authors found increased anti-thyroid antibodies in 17 of 100 patients (17%), with 13 out of 17 patients showing increased ASIs (76%; range 1.4–4.1). Choosing ASI levels of >2 led to positive findings in six out of 16 patients (38%) with anti-TPO antibodies in their serum but no increase in ASIs in three patients (0%) who were seropositive for anti-TG antibodies. The patients with elevated ASIs (N = 13) were younger than the ASI-negative patients (N = 87; p = 0.009); no differences were noted in the frequency of CSF, electroencephalography, and/or magnetic resonance imaging alterations. Discussion: A subgroup of seropositive patients showed intrathecal synthesis of anti-TPO and, more rarely, of anti-TG antibodies, which might be an indication of central autoimmunity in a subgroup of patients with unipolar depression. The confirmation of elevated ASIs as a biomarker for Hashimoto encephalopathy must await further studies. The relevance of the findings is limited by the study’s retrospective and uncontrolled design.

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Jafri, Atif Raza, Amer Baghdadi, M. Najam-ul-Islam, and Michel Jezequel. "Heterogeneous Multi-ASIP and NoC-Based Architecture for Adaptive Parallel TBICM-ID-SSD." IEEE Transactions on Circuits and Systems II: Express Briefs 64, no. 3 (March 2017): 259–63. http://dx.doi.org/10.1109/tcsii.2016.2555018.

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Vishnyakova, A. Yu, A. B. Berdalin, D. A. Golovin, S. E. Lelyuk, and V. G. Lelyuk. "Similarities and differences in ultrasound of extracranial brachiocephalic atherosclerotic lesions in patients with ischemic anterior and posterior circulation stroke." Cardiovascular Therapy and Prevention 20, no. 1 (February 19, 2021): 2437. http://dx.doi.org/10.15829/1728-8800-2021-2437.

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Aim. To establish similarities and differences in ultrasound of extracranial brachiocephalic atherosclerotic lesions in patients with ischemic anterior and posterior circulation stroke.Material and methods. The study involved 668 patients (men, 370; women, 298) with carotid territory IS aged 63±11 and 69±9 years, respectively, and 235 patients (men, 129; women, 106) with vertebrobasilar (VB) territory IS aged 59±12 and 63±10 years, respectively, who underwent duplex ultrasound.Results. Atherosclerotic plaques (ASP) in the internal carotid arteries (ICA) were diagnosed significantly more often (p<0,05) (right ICA (ICAr) — 44,0% of cases; left ICA (ICAl) — 48,4%) and the degree of stenosis of ICA mouths was significantly higher (p<0,05) (ICAr —53±23%, ICAl — 54±24%) in carotid territory IS than in VB territory IS (ICAr — 34,0% of cases; average degree of stenosis — 47±18%; ICAl — 33,6%, average degree of stenosis — 46±18%. There were no significant differences in the prevalence of ASP in vertebral arteries and related stenosis in IS in both territories. Also, there were no significant intergroup differences in the prevalence of homogeneous anechoic or hypoechoic and heterogeneous with hypoechoic predominance ASPs in the ICA mouths: in carotid territory IS, such ASPs were detected in each ICA in 33,5% of cases; in VB territory IS, in 29,6% of cases.Conclusion. In patients with carotid and VB territory IS, risky ASPs were recorded with the same frequency, while the overall prevalence of ASPs and the stenosis degree of ICA mouths was significantly higher in carotid IS.

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Yamazaki, Tomoya, Yuki Kimura, Peter G. Vekilov, Erika Furukawa, Manabu Shirai, Hiroaki Matsumoto, Alexander E. S. Van Driessche, and Katsuo Tsukamoto. "Two types of amorphous protein particles facilitate crystal nucleation." Proceedings of the National Academy of Sciences 114, no. 9 (February 13, 2017): 2154–59. http://dx.doi.org/10.1073/pnas.1606948114.

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Nucleation, the primary step in crystallization, dictates the number of crystals, the distribution of their sizes, the polymorph selection, and other crucial properties of the crystal population. We used time-resolved liquid-cell transmission electron microscopy (TEM) to perform an in situ examination of the nucleation of lysozyme crystals. Our TEM images revealed that mesoscopic clusters, which are similar to those previously assumed to consist of a dense liquid and serve as nucleation precursors, are actually amorphous solid particles (ASPs) and act only as heterogeneous nucleation sites. Crystalline phases never form inside them. We demonstrate that a crystal appears within a noncrystalline particle assembling lysozyme on an ASP or a container wall, highlighting the role of heterogeneous nucleation. These findings represent a significant departure from the existing formulation of the two-step nucleation mechanism while reaffirming the role of noncrystalline particles. The insights gained may have significant implications in areas that rely on the production of protein crystals, such as structural biology, pharmacy, and biophysics, and for the fundamental understanding of crystallization mechanisms.

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Menezes, Carolina Maia, Ravane Vasconcelos Santos, and Mariana Carvalho Gavazza. "Análise situacional de saúde da primeira infância." Revista de Saúde Coletiva da UEFS 11, no. 1 (May 3, 2021): e5464. http://dx.doi.org/10.13102/rscdauefs.v11i1.5464.

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A atenção básica é a principal porta de entrada nos serviços de saúde, atuando na coordenação do cuidado e resolução dos problemas de saúde. A Estratégia de Saúde da Família trabalha com abordagem territorial e comunitária, com definição, adscrição da clientela, cadastramento e acompanhamento da população. Dessa forma, o planejamento e programação em saúde é fundamental para os processos de trabalho através da Análise Situacional de Saúde (ASIS). Este trabalho traz um relato de experiência da Residência Multiprofissional em Saúde Coletiva sobre o processo de construção e realização da ASIS da primeira infância em uma Unidade de Saúde da Família no município de Salvador, no ano 2019. Foi encontrada distribuição heterogênea de crianças na primeira infância de acordo com a microárea e subnotificação das condições de saúde, especialmente das deficiências. Nas oficinas com profissionais e usuários, foram elencados problemas semelhantes relacionados ao acesso e utilização dos serviços de saúde e questões sociais que afetam a primeira infância deste território. A assistência à saúde da criança na USF mostrou-se satisfatória, porém necessitando de melhorias quanto ao monitoramento das crianças. A realização da análise proporcionou maior conhecimento acerca da realidade local, com o recorte da primeira infância e pode ser utilizada como ferramenta o planejamento local em saúde e enfrentamento dos problemas priorizados, tanto para primeira infância quanto para outros ciclos de vida. ABSTRACTThe primary health care is the main gateway in health services system, operating on coordinate care and resolution of health problems. The Family Health Strategy (ESF) works with territorial and community approach, with definition, clientele adscription, registration, and population monitoring. Therefore, planning and programming in health care are fundamental to the work processes through the Health Situational Analysis (ASIS). This article reports an experience of Multi-Professional Residency in Public Health about the construction and conduction process of early childhood ASIS at a Family Health Unit (FHU) in the city of Salvador in 2019. It was found a heterogeneous distribution of children on early childhood according to the micro-area and health conditions underreporting, especially physical and mental deficiencies. In workshops with professionals and users, similar problems were related to access and use of health services and social matters that affect early childhood in this territory were listed. Child’s health care assistance in FHU proved to be satisfactory, however, needing improvement in the children monitoring. The conduction of ASIS provided greater knowledge about the local reality, with the cutout of early childhood. It can be used as a tool both to the local planning in health care and the coping of prioritized problems as early childhood and other life cycles.Keywords: Health Planning; Child Development; Primary Health Care. RESUMENLa atención primaria es la principal puerta de acceso a los servicios de salud, trabajando para coordinar la atención y resolver los problemas de salud. La Estrategia Salud de la Familia trabaja con un enfoque territorial y comunitario, con definición, asignación de clientes, registro y seguimiento de la población. Así, la planificación y programación de la salud es fundamental para los procesos de trabajo a través del Análisis Situacional de Salud (ASIS). Este artículo es un relato de experiencia de la Residencia Multiprofesional en Salud Pública sobre el proceso de construcción e implementación de ASIS de la primera infancia en una Unidad de Salud de la Familia (USF) en la ciudad de Salvador, en el año 2019. Se encontró una distribución heterogénea de niños en la primera infancia. niñez según el área micro y subregistro de condiciones de salud, especialmente discapacidad. En los talleres con profesionales y usuarios se enumeraron problemas similares relacionados con el acceso y uso de los servicios de salud y los problemas sociales que afectan a la primera infancia de este territorio. La atención de la salud infantil en la USF demostró ser satisfactoria, pero es necesario mejorar el seguimiento de los niños. La realización del análisis brindóun mayor conocimiento sobre la realidad local, con el corte de la primera infancia y se puede utilizar como herramienta la planificación local en salud y el afrontamiento de los problemas priorizados tanto para la primera infancia como para otros ciclos vitales.Palabras Clave: Planificación en Salud; Desarrollo Infantil; Atención Primaria de Salud.

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Schoffski, Patrick, Che-Jui Lee, Tom Van Cann, Jasmien Wellens, Inti Zlobec, Judith V. M. G. Bovée, Christian Britschgi, Raf Sciot, and Agnieszka Wozniak. "Establishment of a tissue microarray (TMA) platform as an efficient tool for soft tissue sarcoma (STS) research available for collaboration." Journal of Global Oncology 5, suppl (October 7, 2019): 38. http://dx.doi.org/10.1200/jgo.2019.5.suppl.38.

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38 Background: STS is a very heterogeneous family of orphan malignancies, characterized by morphological and genetic diversity. Tissue samples from individual STS patients are commonly used for routine diagnostic and research purposes. TMAs from multiple sarcoma tissue blocks have potential advantages over conventional tissue analysis in terms of efficiency and cost-effectiveness. We have established a comprehensive sarcoma TMA research platform. Methods: TMAs were constructed using left-over tissue from STS patients diagnosed at University Hospitals Leuven (B), Leiden University Medical Center (NL) and University Hospital Zürich (CH), and from patients with orphan sarcomas enrolled in EORTC trial 90101 “CREATE”. The clinical cases are well annotated in terms of diagnosis, treatment and follow-up. Each TMA block contains duplicate/triplicate 1.0-1.5 mm tissue cores from representative areas selected by sarcoma pathologists. The construction of TMAs was performed using TMA Grand Master (3DHistech) at University of Bern (CH) and in Leiden (NL). Results: The following subtype-specific TMAs have been created: clear cell sarcoma (CCSA, 54 cases), alveolar soft part sarcoma (ASPS, 59), inflammatory myofibroblastic tumor (IMFT, 33), alveolar rhabdomyo- (24) and leiomyosarcoma (55). For CCSA, ASPS and IMFT we have matching TMAs from clinical routine and patients entered in EORTC 90101. As a tool for broader drug- and target-screening purposes in STS we also produced a multi-sarcoma TMA combining multiple, more common subtypes on one block: angio-, dedifferentiated, pleomorphic and myxoid lipo-, leiomyo-, myxofibro-, rhabdomyo-, synovial and undifferentiated pleomorphic sarcoma, and MPNST, with 7-11 individual cases per tumor type. TMA construction is ongoing in other relevant sarcoma subtypes. Conclusions: We are currently expanding a very useful TMA platform representing the broad heterogeneity of STS, from more common to ultra-rare variants. TMAs are available for rapid, cost-effective morphological, histochemical and molecular characterization and identification of novel drug targets in collaboration with academic and commercial partners.

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Shah, Shalini. "Evidence-Based Risk Mitigation and Stratification during COVID-19 for Return to Interventional Pain Practice: American Society of Interventional Pain Physicians (ASIPP) Guidelines." Pain Physician 4S;23, no. 8;4S (August 14, 2020): S161—S182. http://dx.doi.org/10.36076/ppj.2020/23/s161.

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Background: Chronic pain patients require continuity of care even during the COVID-19 pandemic, which has drastically changed healthcare and other societal practices. The American Society of Interventional Pain Physicians (ASIPP) has created the COVID-ASIPP Risk Mitigation and Stratification (COVID-ARMS) Return to Practice Task Force in order to provide guidance for safe and strategic reopening. Objectives: The aims are to provide education and guidance for interventional pain specialists and their patients during the COVID-19 pandemic that minimizes COVID-related morbidity while allowing a return to interventional pain care. Methods: The methodology utilized included the development of objectives and key questions with utilization of trustworthy standards, appropriate disclosures of conflicts of interest, as well as a panel of experts from various regions, specialities, and groups. The literature pertaining to all aspects of COVID-19, specifically related to epidemiology, risk factors, complications, morbidity and mortality, and literature related to risk mitigation and stratification were reviewed. The principles of best-evidence synthesis of available literature and grading for recommendations as described by the Agency for Healthcare Research and Quality (AHRQ), typically utilized in ASIPP guideline preparation, was not utilized in these guidelines due to the limitation based on lack of available literature on COVID-19, risk mitigation and stratification. Consequently, these guidelines are considered evidence-informed with the incorporation of the best-available research and practice knowledge. Results: Numerous risk factors have emerged that predispose patients to contracting COVID-19 and/or having a more severe course of the infection. COVID-19 may have mild symptoms, be asymptomatic, or may be severe and life-threatening. Older age and certain comorbidities, such as underlying pulmonary or cardiovascular disease, have been associated with worse outcomes. In pain care, COVID-19 patients are a heterogeneous group with some individuals relatively healthy and having only a short course of manageable symptoms, while others become critically ill. It is necessary to assess patients on a case-by-case basis and craft individualized care recommendations. A COVID-19 ARMS risk stratification tool was created to quickly and objectively assess patients. Interventional pain specialists and their patients may derive important benefits from evidenceinformed risk stratification, protective strategies to prevent infection, and the gradual resumption of treatments and procedures to manage pain. Limitations: COVID-19 was an ongoing pandemic at the time these recommendations were developed. The pandemic has created a fluid situation in terms of evidence-informed guidance. As more and better evidence is gathered, these recommendations may be modified. Conclusions: Chronic pain patients require continuity of care, but during the time of the COVID-19 pandemic, steps must be taken to stratify risks and protect patients from possible infection to safeguard them from COVID-19-related illness and transmitting the disease to others. Pain specialists should optimize telemedicine encounters with pain patients, be cognizant of risks of COVID-19 morbidity, and take steps to evaluate risk-benefit on a case-by-case basis. Pain specialists may return to practice with lower-risk patients and appropriate safeguards. Key words: Cardiovascular disease, COVID-19, interventional pain management, COVID risk factors, diabetes, hypertension, interventional pain care, novel coronavirus, obesity, SARS-nCoV2, steroids

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Mätlik, Kert, Kaja Redik, and Mart Speek. "L1 Antisense Promoter Drives Tissue-Specific Transcription of Human Genes." Journal of Biomedicine and Biotechnology 2006 (2006): 1–16. http://dx.doi.org/10.1155/jbb/2006/71753.

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Transcription of transposable elements interspersed in the genome is controlled by complex interactions between their regulatory elements and host factors. However, the same regulatory elements may be occasionally used for the transcription of host genes. One such example is the human L1 retrotransposon, which contains an antisense promoter (ASP) driving transcription into adjacent genes yielding chimeric transcripts. We have characterized 49 chimeric mRNAs corresponding to sense and antisense strands of human genes. Here we show that L1 ASP is capable of functioning as an alternative promoter, giving rise to a chimeric transcript whose coding region is identical to the ORF of mRNA of the following genes:KIAA1797,CLCN5, andSLCO1A2. Furthermore, in these cases the activity of L1 ASP is tissue-specific and may expand the expression pattern of the respective gene. The activity of L1 ASP is tissue-specific also in cases where L1 ASP produces antisense RNAs complementary toCOL11A1andBOLLmRNAs. Simultaneous assessment of the activity of L1 ASPs in multiple loci revealed the presence of L1 ASP-derived transcripts in all human tissues examined. We also demonstrate that L1 ASP can act as a promoter in vivo and predict that it has a heterogeneous transcription initiation site. Our data suggest that L1 ASP-driven transcription may increase the transcriptional flexibility of several human genes.

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Keizman, Daniel, David Sarid, Jae-Lyun Lee, Maya Gottfried, Natalie Maimon, Hans J. Hammers, Mario A. Eisenberger, et al. "Patients with metastatic chromophobe renal cell carcinoma treated with sunitinib therapy: Analysis of an international database regarding outcome and comparison to clear cell histology (mccRCC)." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 429. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.429.

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429 Background: Sunitinib (Su) is a standard therapy (tx) for mccRCC. Data on its activity in the rare variant of metastatic chromophobe renal cell carcinoma (mchRCC) are limited by very small or heterogeneous (mixed histology with papillary type, or mixed targeted therapies) studies. We analyzed the activity of Su in a relatively large and homogenous international cohort of mchRCC pts, in terms of outcome and comparison to mccRCC. Methods: Records from mchRCC pts treated with first-line Su in 9 centers across 4 countries were retrospectively reviewed. Univariate and multivariate analyses of association between clinicopathologic factors and outcome were performed. Subsequently, mchRCC pts were individually matched to mccRCC pts. We compared the response rate (RR), progression free survival (PFS), and overall survival (OS) between the groups. Results: Between 2004-2014, 33 pts (median age 64, 45% male) with mchRCC were treated with Su as first-line tx. 76% had a prior nephrectomy. HENG risk was good 27%, intermediate 55%, and poor 18%. 33% were active smokers, and 30% users of angiotensin system inhibitors (ASIs). 55%, 27%, and 33% had lung, liver, and bone metastases, respectively. 48% had a pre-tx neutrophil to lymphocyte ratio (NLR) >3. 42% had dose reduction/tx interruption (DR/TI). Su-induced hypertension (HTN) occurred in 48%. 75% achieved a clinical benefit (partial response + stable disease), while 25% had disease progression within the first 3 months of tx. Median PFS and OS were 10 and 26 months, respectively. Factors associated with PFS were the HENG risk (HR 3.8, p=0.025) and pre-tx NLR >3 (HR 0.6, p=0.012). Factors associated with OS were the HENG risk (HR 4.27, p=0.027), liver metastases (HR 4.6, p=0.029), and pre-treatment NLR <3 (HR 0.5, p=0.04). Tx outcome was not significantly different between mchRCC pts and mccRCC pts, who were individually matched by HENG risk, nephrectomy/smoking status, pre-tx NLR, use of ASIs, DR/TI, and Su induced HTN. In mccRCC pts (p value versus mchRCC), 70% achieved a clinical benefit (p=0.58), and median PFS and OS were 9 (p=0.7) and 24 (p=0.6) months, respectively. Conclusions: In mchRCC pts, Su tx may have similar outcome to mccRCC pts.

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Álvarez-Marín, Rocío, Lorena López-Cerero, Francisca Guerrero-Sánchez, Begoña Palop-Borras, María Dolores Rojo-Martín, Andrés Ruiz-Sancho, Carmen Herrero-Rodríguez, et al. "Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gram-negative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases." Journal of Antimicrobial Chemotherapy 76, no. 7 (March 26, 2021): 1928–36. http://dx.doi.org/10.1093/jac/dkab073.

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Abstract Background Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide and carbapenem use facilitates their spread. Antimicrobial stewardship programmes (ASPs) can help to optimize the use of antibiotics. This study evaluates the impact of a multifaceted educational ASP on carbapenem use and on the epidemiology of CR-GNB. Methods We conducted a quasi-experimental, time-series study in seven hospitals, from January 2014 to September 2018. The key intervention was composed of educational interviews promoting the appropriate use of carbapenems. The primary endpoints were carbapenem consumption and incidence density (ID) of CR-GNB. All non-duplicated CR-GNB clinical isolates were tested using phenotypic assays and PCR for the presence of carbapenemases. Joinpoint regression and interrupted time-series analyses were used to determine trends. Results A decrease in carbapenem consumption throughout the study period [average quarterly percentage change (AQPC) −1.5%, P < 0.001] and a −8.170 (−16.064 to −0.277) level change following the intervention were observed. The ID of CR-Acinetobacter baumannii decreased (AQPC −3.5%, P = 0.02) and the overall ID of CR-GNB remained stable (AQPC −0.4%, P = 0.52). CR-GNB, CR-Pseudomonas aeruginosa and CR-A. baumannii IDs per hospital correlated with the local consumption of carbapenems. The most prevalent carbapenem resistance mechanisms were OXA-23 for CR-A. baumannii (76.1%), OXA-48 for CR-Klebsiella pneumoniae (66%) and no carbapenemases for CR-P. aeruginosa (91.7%). The epidemiology of carbapenemases was heterogeneous throughout the study, especially for carbapenemase-producing Enterobacteriaceae. Conclusions In conclusion, a multifaceted, educational interview-based ASP targeting carbapenem prescribing reduced carbapenem use and the ID of CR-A. baumannii.

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Tang, Lingjia. "Session details: Session 7A: Accelerators: GPUs, ASICs, and Heterogeneous Systems." ACM SIGPLAN Notices 52, no. 4 (May 12, 2017). http://dx.doi.org/10.1145/3262067.

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Tang, Lingjia. "Session details: Session 7A: Accelerators: GPUs, ASICs, and Heterogeneous Systems." ACM SIGARCH Computer Architecture News 45, no. 1 (May 11, 2017). http://dx.doi.org/10.1145/3263399.

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Wang, Yu-Qing, and Chang Xu. "Cluster dynamics in the open-boundary heterogeneous ASEPs coupled with interacting energies." European Physical Journal Plus 135, no. 6 (June 2020). http://dx.doi.org/10.1140/epjp/s13360-020-00495-5.

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Ruiz-Ramos, Jesus, Emili Vallvé Alcón, Francisco Moreno Ramos, Rosario Santolaya-Perrín, and Jose María Guardiola Tey. "Antimicrobial stewardship programs in emergency departments: how do we measure antimicrobial use? A systematic review." Revista Española de Quimioterapia, September 15, 2021. http://dx.doi.org/10.37201/req/028.2021.

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Objectives. The implementation of antimicrobial stewardship programs (ASPs) has become a usual practice in hospital settings. However, the method for monitoring antimicrobial use in accident and emergency departments (ED) is not yet adequately defined. Thus, the objective of this review is to describe antimicrobial use indicators used by ASPs implemented in ED. Material and methods. A systematic review was performed based on studies found in the following academic research databases: MEDLINE, EMBASE, Web of Science, and Scopus (Period: January 2000 to December 2019). Controlled clinical trials, before-and-after studies, interrupted time series, and repeated measures studies assessing the impact of ASPs on antimicrobial use in ED were included; studies published in languages other than English or Spanish were excluded from this review. Results. Twenty-six studies met the inclusion criteria and were included in this systematic review. In total, 15 (62.5%) studies described the ASP team members who collaborated with the ED staff. Most (21; 80.8%) studies used the percentage of patients with an antibiotic prescription as an indicator. Four (15.4%) studies included defined daily dose data. The antibiotic treatment duration was reported in four (15.4%) studies. Only two studies assessed the impact of the ASP using microbiological indicators, both of which used the incidence of infection with Clostridioides difficile as the indicator. Conclusions. The reports of experiences in implementing ASPs in ED show heterogeneous antimicrobial use indicators, which makes it difficult to compare results. Therefore, antimicrobial use indicators for ASPs must be standardised between hospital units.

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Sayal, Aseem, Paras Ajay, Mark W. McDermott, S. V. Sreenivasan, and Jaydeep P. Kulkarni. "M2A2: Microscale Modular Assembled ASICs for High-Mix, Low-Volume, Heterogeneously Integrated Designs." IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2020, 1. http://dx.doi.org/10.1109/tcad.2020.2982621.

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Journal articles on the topic 'Heterogeneous ASIPs'

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