Dissertations / Theses on the topic 'Hepatitis C Social aspects'
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Boner, Winifred. "HBV pre-C/C variation : geographical and functional aspects." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360172.
Full textRolfe, Kathryn Jane. "Molecular aspects of hepatitis C virus infection and associated mitochondrial DNA damage." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495578.
Full textYuen, Man-fung, and 袁孟峰. "Role of hepatitis B virus genotypes B and C on chronic liver disease in the Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B33710089.
Full textFisher, Scott Andrew. "Clinical and molecular analysis of the hepatitis C virus." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0099.
Full textNorthfield, John. "Aspects to T-cell phenotype during infection with HIV, CMV and Hepatitis C virus." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:283098ce-e24d-4099-8826-07dcc75381f2.
Full textDavis, Christopher A. "The role of Claudin-CD81 Co-Receptor interaction(s) in Hepatitis C virus entry." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2844/.
Full textGrove, Joseph. "The role of scavenger receptor B-I in hepatitis C virus attachment and entry." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/347/.
Full textPoliakov, Anton. "Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design." Doctoral thesis, Uppsala universitet, Institutionen för naturvetenskaplig biokemi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4127.
Full textThetford, H. Clare, and clare_thetford@yahoo com. "Reconceiving the Spoiled Female Identity: Childbearing and Motherhood among Women with Hepatitis C." The Australian National University. Research School of Social Sciences, 2004. http://thesis.anu.edu.au./public/adt-ANU20050331.222115.
Full textMouton, Marlize National Centre in HIV Social Research Faculty of Arts & Social Sciences UNSW. ""More than a liver" - the role of the social work practitioner in hepatitis C treatment centres." Publisher:University of New South Wales. National Centre in HIV Social Research, 2008. http://handle.unsw.edu.au/1959.4/41466.
Full textGómez, Garmendia Jon. "Exclusión farmacéutica: un análisis criminológico sobre el caso de la hepatitis C en Galicia." Doctoral thesis, Universitat de Barcelona, 2022. http://hdl.handle.net/10803/673286.
Full textWith the COVID-19 pandemic, the issue of the Right of Access to Essential Medicines (RAME) has gained prominence. An issue that, above all, has become the subject of debate with the global inequity in accessibility to vaccines or the failure to suspend the patents that protect them. However, this work was initiated before the pandemic and reflects, in part, that the problem already existed before. Thus, this research focused on one of the problems related to the non-guarantee of the RAME: pharmaceutical exclusion. A broad and multidimensional process that involves barriers to access to medicines and is, in part, the result of the action or omission of entities and institutions that have responsibilities in guaranteeing the RAME. The purpose of the study was to learn more about how this harm occurs. A task that, for this purpose, had as an object of study the events that took place in Galicia regarding the non-access to Sovaldi for people affected by hepatitis C and the struggle carried out by the Plataforma Galega de Afectad@s pola Hepatite C (PGAHC). Some stories and experiences that through the interviews reflected that from a criminological point of view we could say that we are facing a structural injustice or violence and that the deterioration of the health system (including cuts in public spending) and the monopoly situation of the pharmaceutical industry (specially to set the prices of medicines) encourage such problems. Problems that, in short, reflect the conflict between capital and life and leave evidence of the need to expand the fields of study of criminology, the importance of looking from sustainability to life and the necessary critical spirit about the present and the future in relation to the DAME and the consequences that the pandemic will bring.
Amb la pandèmia de la COVID-19 la qüestió del Dret a l'Accés a Medicaments Essencials (DAME) ha adquirit protagonisme. Un assumpte que, sobretot, s'ha convertit amb objecte de debat amb la iniquitat mundial en l'accessibilitat a les vacunes o la no suspensió de les patents que les protegeixen. Tanmateix, aquest treball va ser iniciat abans de la pandèmia i reflexa, en part, que el problema ja venia d'abans. Així, aquesta investigació va tenir com objecte un dels problemes relatius a la no garantia del DAME: l'exclusió farmacèutica. Un procés ampli i multidimensional que implica barreres en l'accés a medicaments i és, en part, el resultat de l'acció o omissió d'entitats i institucions que tenen responsabilitats en la garantia del DAME. La finalitat d'aquest treball va consistir a conèixer i profunditzar com es produeix aquest dany. Una tasca que va tenir com objecte d'estudi els successos que van tenir lloc a Galícia amb relació al no accés de Sovaldi a les persones afectades per l'hepatitis C i la lluita realitzada per la Plataforma Galega de Afectad@s pola Hepatite C (PGAHC). Unes històries i experiències que, a través de les entrevistes, reflectiren que des de el punt de vista criminològic podríem dir que ens trobem davant d'una injustícia o violència estructural i que el deteriorament del sistema sanitari (incloses les retallades de la despesa pública) i la solució del monopoli de la Indústria farmacèutica (sobretot per fixar els preus dels medicaments) fomenten aquests tipus de problemes. Uns problemes que, en definitiva, són un reflex més del conflicte que existeix entre el capital i la vida i deixen constància sobre la necessitat d'ampliar els camps d'estudi de la criminologia, la importància de mirar des de la sostenibilitat a la vida i la necessitat d'un esperit crític sobre el present i el futur en relació amb el DAME i les conseqüències que esdevindran arran de la pandèmia.
Coa pandemia da COVID-19 gañou protagonismo a cuestión do Dereito ao Acceso a Medicamentos Esenciais (DAME). Unha cuestión que, sobre todo, converteuse en obxecto de debate coa desigualdade mundial na accesibilidade das vacinas ou a non suspensión das patentes que as protexen. Non obstante, este traballo iniciouse antes da pandemia e reflicte, en parte, que o problema xa viña de antes. Así, esta investigación tivo como obxecto un dos problemas relacionados coa non garantía do DAME: a exclusión farmacéutica. Un proceso amplo e multidimensional que implica barreiras no acceso a medicamentos e é, en parte, o resultado da acción ou omisión de entidades e institucións que teñen responsabilidades en garantir o DAME. A finalidade do traballo consistiu en coñecer e afondar en como se producen estes danos. Unha tarefa que, para iso, tivo como obxecto de estudo os sucesos acontecidos en Galicia arredor da falta de acceso ao Sovaldi por parte das persoas afectadas pola hepatite C e a loita levada a cabo pola Plataforma Galega de Afectad@s pola Hepatite C (PGAHC). Unhas historias e experiencias que a través das entrevistas reflectiron que desde o punto de vista criminolóxico poderiamos dicir que estamos ante unha inxustiza ou violencia estrutural e que o deterioro do sistema sanitario (incluídos os recortes no gasto público) e a situación de monopolio da Industria Farmacéutica (sobre todo, para fixar os prezos dos medicamentos) promove este tipo de problemas. Uns problemas que, en definitiva, son un reflexo máis do conflito que existe entre o capital e a vida e amosan a necesidade de ampliar os campos de estudo da criminoloxía, a importancia de mirar desde a sostibilidade á vida e o necesario espírito crítico sobre o presente e o futuro en relación co DAME e as consecuencias que traerá a pandemia.
COVID-19 pandemiarekin Oinarrizko Sendagaiak Eskuratzeko Eskubidearen (OSEE) auziak protagonismoa hartu du. Gai hori eztabaidagai bihurtu da, batez ere, mundu mailan txertoekiko dagoen eskuragarritasun urria eta horiek babesten dituzten patenteen etete eza dela eta. Hala ere, pandemia baino lehen hasi zen lan honek, neurri batean, arazoa lehenagotik zetorrela islatzen du. Hala, ikerketa honen aztergaia OSEEren berme ezari buruzko arazoetako bat izan zen: bazterketa farmazeutikoa. Prozesu zabal eta multidimentsional bat, sendagaiak eskuratzeko oztopoak dakartzana eta, neurri batean, OSEEren bermean erantzukizunak dituzten erakunde eta instituzioen ekintzaren edo omisioaren emaitza dena. Honela, lanaren helburua kaltea nola gertatzen den ezagutzea eta sakontzea izan zen. Horretarako, Galizian C hepatitisak jotako pertsonek Sovaldia eskuragarri ez izateari eta Plataforma Galega de Afectad@s pola Hepatite C- ek (PGAHC) egindako borrokari buruz gertatutakoak aztertu ziren. Elkarrizketen bidez, historia eta esperientzia horiek ikuspegi kriminologikotik injustizia edo egiturazko indarkeria baten aurrean gaudela eta osasun-sistemaren narriadurak (gastu publikoaren murrizketak barne) eta farmazia-industriaren monopolio egoerak (batez ere, botiken prezioak finkatzeko) horrelako arazoak sustatzen dituztela erakutsi zuten. Azken batean, arazo horiek kapitalaren eta bizitzaren artean dagoen gatazkaren beste isla bat dira, eta agerian uzten dute kriminologiaren azterketa-eremuak zabaltzeko beharra, iraunkortasunetik bizitzara begiratzearen garrantzia eta OSEE delakoari eta pandemiak ekarriko dituen ondorioei dagokionez, orainari eta etorkizunari buruzko espiritu kritikoa sustatzeko beharra.
黎程正家 and Cheng Cheng-gea Alice Lai. "Parenting and children's social competence in families with hepatitis B virus (HBV) in Guangzhou: an ecologicalstudy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31234227.
Full textPerzynski, Adam Thomas. "Between Facts and Voices: Medical and Lay Knowledge of the Spread of Hepatitis C." online version, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=case1207328082.
Full textBangah, Ramesh. "The State of Needle Exchange Programs in Sweden and Hepatitis C Virus Incidence." Thesis, Södertörns högskola, Miljövetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-40833.
Full textBuchanan, Ryan Malcolm. "The social and genetic epidemiology of Hepatitis C in an isolated network of people who inject drugs." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/417993/.
Full textKirkpatrick, Raelene. "A mathematical analysis of the financial and medical impact of hepatitis C among drug users in Perth, Western Australia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2003. https://ro.ecu.edu.au/theses/1332.
Full textGritt, Andrew Jonathan. "Aspects of agrarian change in south-west Lancashire, c.1650-1850." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/19663/.
Full textMartin, Lisa Marie. "Socio-Demographic, Clinical, and Social Influences on Health-Related Quality of Life in individuals with Hepatitis C (HCV)." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1212677301.
Full textLaughton, Jane. "Aspects of the social and economic history of late medieval Chester, 1350-c.1500." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/273128.
Full textTerrell, Terran A. "A Geographical Examination of Social, Behavioral, and Demographic Determinants Association with Hepatitis C Viral Infection in the State of Georgia." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/iph_theses/143.
Full textEklund, Per-Olof. "Psykosociala problem vid hepatit C." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-26624.
Full textCertain diseases carry consequences beyond the somatic burden. Hepatitis C is one of them. This virus influences the infected beyond its pathological description. Every year 2000 cases of Hepatitis C are reported in Sweden. The aim of this study was to illuminate the extent and character of psychosocial problems in patients with the diagnosis hepatitis C. The study is based on seven scientific articles. The seven steps for a literature study presented by Goodman inspired the research process. As a theoretical frame of reference Carnevali´s model for a functional and healthy daily life has been used. The analysis resulted in four themes: (1) Stigmatization, (2) fear associated with hepatitis C, (3) depressive symptoms connected with the diagnosis and (4) lack of social support The results indicate that patients with the diagnosis hepatitis C experience psychosocial problems to a larger extent. This also means that these patients are negatively influenced leading to a decreased opportunity to experience health.
Trepo, Eric. "Role of genetic factors in the progression of fibrosis in alcoholic liver disease and chronic hepatitis C." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209659.
Full textLes travaux réalisés dans le cadre de cette thèse ont permis de montrer que :
1) Le CRS avait la capacité de prédire la progression de la fibrose chez des patients caucasiens ayant une HCC dans 2 cohortes européennes indépendantes.
2) Par ailleurs, dans la MAF, nous avons répliqué chez des patients caucasiens l’association entre le SNP rs738409 dans le gène PNPLA3 et la cirrhose. Nous avons également montré pour la première fois, que l’expression de PNPLA3 était significativement diminuée chez les patients avec une fibrose plus avancée. De plus, nous avons observé dans 2 cohortes européennes que rs738409 était également associé à la prévalence du CHC.
3) Enfin, nous avons également mis en évidence l’impact de ce même SNP sur la stéatose hépatique et la fibrose dans l’HCC sans toutefois qu’il influence la réponse à la thérapie antivirale dans 3 cohortes caucasiennes indépendantes.
Ainsi de manière remarquable, un même SNP (rs738409) apparait associé à des lésions hépatiques sévères dans les trois pathologies hépatiques chroniques les plus fréquentes (la MAF, l’HCC et la NAFLD). Ceci suggère des voies pathogéniques communes de la fibrogénèse hépatique. Par ailleurs, ces travaux soulignent indirectement que les GWAS ont la capacité d’ouvrir de nouvelles voies physiopathologiques et d’identifier de nouveaux variants, gènes ou région génétiques capables de constituer de nouveaux biomarqueurs et cibles thérapeutiques dans l’HCC et la MAF.
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished
Borsay, Anne. "Patrons and governors : aspects of the social history of the Bath Infirmary, c.1739-1830." Thesis, University of Wales Trinity Saint David, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683159.
Full textYoung, Craig. "The economic, social and geographical aspects of rural tradespeople in Scotland, with specific reference to Lowland Perthshire, c.1750-c.1950." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/26066.
Full textGriffiths, Paul. "Some aspects of social history of youth in early modern England, with particular reference to the period c.1560-c.1640." Thesis, University of Cambridge, 1992. https://www.repository.cam.ac.uk/handle/1810/273130.
Full textClarida, Jill Courtney. "Substance Abuse and Psychosocial Factors in the Hepatitis C Population: Identifying Risk Factors in Disease Severity and Quality of Life." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1531.
Full textCôco, Layla Tatiane [UNESP]. "Adesão ao tratamento da Hepatite C - o papel das variáveis sociodemográficas e psicológicas: revisão integrativa." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144422.
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Introdução: Adesão ao tratamento refere-se a um comportamento ativo do paciente em relação à doença e ao tratamento compartilhando as decisões com o profissional de saúde. Considera-se a adesão um fenômeno resultante da interação de fatores de diferentes naturezas que afetam diretamente o comportamento do paciente: fatores relacionados ao indivíduo; fatores sociais, econômicos; fatores relacionados ao serviço de saúde e aos profissionais de saúde e ainda os fatores relacionados à doença e ao tratamento. Objetivo: Este estudo propõe-se a realizar uma revisão integrativa da literatura nacional e internacional sobre fatores associados à adesão ao tratamento da Hepatite C, com especial ênfase aos fatores psicológicos e sociais. Método: Foram estabelecidas as várias fases deste estudo, segundo o procedimento proposto: elaboração da pergunta de pesquisa, estabelecimento dos critérios para seleção da amostra, apresentação das características das pesquisas selecionadas, análise dos dados, interpretação dos resultados e a síntese da revisão. Realizou-se busca dos artigos nas bases de dados: Medline, Web of Science, Cinahl, Lilacs, Psycinfo, Scopus e Scielo. Foram incluídos artigos nos idiomas português, inglês e espanhol, publicados entre os anos 2000 a 2016 e excluídos os artigos que não foram considerados pertinentes ao objeto de estudo. Resultados: Obteve-se um corpus com 14 artigos, totalmente estrangeiro, publicado em inglês, nos anos de 2001 a 2015, majoritariamente indexados no Medline, o método quantitativo predominou entre as pesquisas selecionadas (onze artigos) em relação aos qualitativos (três artigos). As variáveis psicológicas pesquisadas em relação à possível associação com a adesão/não adesão ao tratamento de Hepatite C, nos estudos quantitativos, foram: presença de sintomas psicológicos, como ansiedade e depressão, raiva, hostilidade, transtornos psiquiátricos, autoeficácia, ainda foram investigados funcionamento social, problemas interpessoais e comportamentos relacionados à saúde. Esses estudos avaliaram também a possível influência na adesão ao tratamento de características sociodemográficas: idade, ocupação, escolaridade, sexo, etnia, apoio social e ainda o uso de álcool e outras drogas (abstinência e tratamento). Entre estes fatores foi verificada associação significativa entre não adesão e presença de transtornos psiquiátricos, sintomas de depressão, ansiedade fóbica, comportamento hostil, intrusividade, uso regular de substâncias, idade (ser mais jovem), desemprego, não estar em relacionamento estável. Já as variáveis associadas estatisticamente com adesão ao tratamento foram iniciar medicação psiquiátrica durante o tratamento, comportamentos relacionados à saúde (dieta e comportamento alimentar), menor distância do centro de tratamento, genótipo 3, coinfectado HIV e virgens de tratamento. Também foram avaliados três estudos qualitativos em que foram apontadas e discutidas como barreiras e como facilitadores da adesão ao tratamento: percepção e experiências com o tratamento, presença de estigma, apoio social, estratégias de enfrentamento, sistemas de crenças, medo e ansiedade. Conclusões: Conhecer os fatores que podem interferir na adesão ao tratamento da Hepatite C é extremamente importante, seja pela gravidade da doença, pelo aumento de sua incidência, pela complexidade e custo do tratamento que exige adesão completa para se obter RVS, além do impacto pessoal e social dessa doença e de seu tratamento, que faz da Hepatite C um problema de saúde pública. Considera-se que a relevância desta revisão está ainda em apontar a necessidade de se ampliarem as pesquisas sobre o papel das variáveis psicológicas e sociais sobre as características da comunicação com os profissionais de saúde que possam favorecer melhor adesão. Pesquisas com esse intuito, ainda tão ausentes na literatura, poderão contribuir para o desenvolvimento de programas psicoeducativos para que se amplie a adesão aos tratamentos hoje disponíveis.
Introduction: Adherence to treatment refers to an active patient behavior regarding the disease and treatment by sharing decisions with the health professional. Adherence is considered a phenomenon resulting from the interaction of factors of different nature that directly affect patient behavior: factors related to the individual; social and economic factors; factors related to health care and health care professionals and also factors related to the disease and treatment. Objective: This study aims to carry out an integrative review of national and international literature of factors associated with adherence to treatment of hepatitis C, with special emphasis to psychological and social factors. Method: We establish the various stages of this study according to the proposed procedure: the development of the research question, establishment of criteria for sample selection, presentation of the characteristics of the selected research, data analysis, interpretation of results and a summary of the review. A search of articles was conducted in the following databases: Medline, Web of Science, CINAHL, Lilacs, Psycinfo, Scopus and Scielo. Complete articles were included, in Portuguese, English and Spanish, published between 2000 and 2016, and articles considered not relevant to the object of study were excluded. Results: Obtained a corpus with 14 totally foreign articles published in English between 2001-2015, mainly indexed in Medline, the quantitative method predominated among the selected studies (eleven articles) against three articles using the qualitative method. The psychological variables studied in relation to the possible association with adherence/non-adherence to treatment of hepatitis C, in the quantitative study were: presence of psychological symptoms such as anxiety and depression, anger, hostility, psychiatric disorders, and self-efficacy, but social functioning, interpersonal problems, behaviors related to health and quality of life were also investigated. These studies also assessed the possible impact on treatment adherence of sociodemographic characteristics: age, occupation, education, gender, ethnicity, social support and even the use of alcohol and other drugs (abstinence and treatment). Among these factors there was significant association between non-adherence and presence of psychiatric disorders, symptoms of depression, phobic anxiety, hostile behavior, intrusiveness, regular substance use, age (being younger), unemployment, not being in a stable relationship. The variables statistically associated with adherence to treatment were: starting psychiatric medication during treatment, health-related behaviors (diet and eating behavior), shorter distance from the center of treatment, genotype 3, HIV co-infected and treatment first timers. The three qualitative studies were also evaluated and the barriers and facilitators of adherence to treatment were identified and discussed: perception and experiences with treatment, presence of stigma, social support, coping strategies, belief systems, fear and anxiety. Conclusions: Knowing the factors that can interfere with adherence to hepatitis C treatment is extremely important because the severity of the disease, the increase in incidence, the complexity and cost of treatment that requires full adherence to achieve SVR in addition to the personal and social impact of the disease and its treatment, which makes it a public health problem. It is considered that the relevance of this review is still to point out the need to expand research on the role of psychological and social variables on the characteristics of communication with health professionals who can promote better adherence. Research to this end, yet so absent from the literature, may contribute to the development of psychoeducational programs to broaden adherence to currently available treatments.
Silva, Ana Heloisa Veras Ayres. "Análise espacial dos casos das hepatites virais B e C no município de Foz do Iguaçu: análise das variáveis associadas." Universidade Estadual do Oeste do Paraná, 2017. http://tede.unioeste.br/handle/tede/3554.
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This study aimed to analyze the incidence of hepatitis B and C, according to spatial variation, in Foz do Iguaçu, between 2010 and 2015. It is an ecological, retrospective, cross-sectional study using spatial analysis techniques. Data from hepatitis B and C cases were obtained from the hepatitis clinic of Foz do Iguaçu and the population-based information from the IBGE. Spatial analysis was performed using the GeoDaTM 1.6.7 and QGIS 2.16 softwares. A positive spatial autocorrelation (I = 0.5953 and I = 0.4798; p <0.05) was found, indicating the presence of census tracts clusters in relation to the incidence rates for hepatitis B and C, respectively. A total of 525 cases of hepatitis B were reported, distributed equally among the sex and predominance of the age range of 35 to 49 years-old. Regarding the raw incidence rate, the average was 52.1 cases per 100,000 inhabitants, and 50 High-High type census tracts were found, mainly in the eastern, northeastern and southern districts of the municipality. In relation to hepatitis C, 177 cases were reported, predominantly in men and in the age range of 50 to 64 years-old. Regarding the raw incidence rate the average was 18.7 cases per 100,000 inhabitants. The High-High pattern was found in 35 census tracts, mainly in the East, West, Northeast and South districts. The socioeconomic indicators that were significantly and positively related to hepatitis B were: other types of housing, per capita income between 2 and more than 10 SM and undeclared income, garbage on land or with another destination, houses with 5 inhabitants, use of water from well or other sources and houses without a bathroom, indicating relation with socioeconomically more vulnerable populations. For hepatitis C, the relation with the socioeconomic pattern was different and there was a significant and positive association with: income of the person in charge of 3 to 15 SM and per capita income of 2 to 3 SM at 5 to 10 SM, water from well, other type of water and other garbage. Significant and negative association was obtained with the variables: householder with no declared income, householder income of up to ½ SM, ½ to 1 SM and 1 to 2 SM, per capita income of ½ to 1 SM and without declared income, water in a network, '3, 5, 8 and 10 residents' and collected garbage, indicating that a higher income and more diverse population is affected. For both infections, the level of literacy of the householders was not significant. Hepatitis B reached mainly the populations of census tracts with poorer socioeconomic patterns, which did not necessarily occur with hepatitis C. In conclusion, the city has high incidence rates of hepatitis B and C, its distributions presented spatial dependence determined by socioeconomic factors of the population. The research opens new possibilities for epidemiological research on viral hepatitis, allowing the reflection about the care, prevention and surveillance of viral hepatitis in the border region.
Este estudio tuvo como objetivo analizar la incidencia de las hepatitis B y C, según variación espacial, en Foz do Iguaçu, entre 2010 y 2015. Es un estudio ecológico, retrospectivo, transversal, utilizando técnicas de análisis espacial. Los datos de los casos de hepatitis B y C fueron obtenidos en el ambulatorio de hepatitis de Foz do Iguaçu y las informaciones de base poblacional junto al IBGE. El análisis espacial se realizó utilizando los programas GeoDaTM 1.6.7 y QGIS 2.16. Se encontró una autocorrelación espacial positiva (I = 0,5953 e I = 0,4798, p <0,05), indicando la presencia de agrupaciones entre los sectores censales en relación a las tasas de incidencia por hepatitis B y C, respectivamente. Se notificaron 525 casos de hepatitis B, distribuidos equitativamente en cuanto al sexo y predominio del grupo de edad de 35 a 49 años. En cuanto a la tasa de incidencia bruta, la media fue de 52,1 casos por 100.000 habitantes, y se encontraron 50 sectores censales con padrón Alto-Alto, principalmente en los distritos Este, Nordeste y Sur del municipio. En relación a la hepatitis C, 177 casos fueron notificados, con predominio en hombres y grupo de edad de 50 a 64 años. En cuanto a la tasa de incidencia bruta, la media fue de 18,7 casos por 100.000 habitantes. El patrón Alto-Alto fue encontrado en 35 sectores censales, principalmente en los distritos Este, Oeste, Nordeste y Sur. Los indicadores socioeconómicos relacionados de forma significativa y positiva con la hepatitis B fueron: otros tipos de vivienda, renta del responsable entre hasta ½ y 2 salarios mínimos (SM), ingreso per cápita entre 2 y hasta más de 10 SM y renta no declarada, basura en terrenos o con otro destino, casas con 5 residentes, utilización de agua de pozo o de otras fuentes y casas sin baño, indicando relación con la población más vulnerable socioeconómicamente. Para la hepatitis C, la relación con el patrón socioeconómico se presentó diferentemente, donde hubo asociación significante y positiva con: rentas del responsable de 3 a 15 SM y ingreso per cápita de 2 a 3 SM a 5 a 10 SM, agua de pozo, agua otros y basura otros. La asociación significante y negativa fue obtenida con las variables: casa propia, sin renta declarada, renta del responsable hasta ½ SM, ½ a 1 SM y 1 a 2 SM, ingreso per cápita de ½ a 1 SM y sin renta declarada, agua en red, "3, 5, 8 y 10 residentes" y basura recogida, indicando que una población de mayor renta y más diversificada es afectada. Para ambas infecciones, el nivel de alfabetización del responsable no fue significativo. La hepatitis B alcanzó principalmente a las poblaciones de sectores censales con un patrón socioeconómico más pobre, lo que no ocurrió necesariamente con la hepatitis C. Se concluye que el municipio presenta altas tasas de incidencia de hepatitis B y C, que sus distribuciones presentaron dependencia espacial, determinado por factores socioeconómicos de la población. La investigación abre nuevas posibilidades de investigación epidemiológica sobre las hepatitis virales, permitiendo una reflexión acerca de la atención, prevención y vigilancia de las hepatitis virales en la región fronteriza.
Este estudo visou analisar a incidência das hepatites B e C, segundo variação espacial, em Foz do Iguaçu, entre 2010 e 2015. É um estudo ecológico, retrospectivo, transversal, utilizando técnicas de análise espacial. Os dados dos casos de hepatites B e C foram obtidos no ambulatório de hepatites de Foz do Iguaçu e as informações de base populacional junto ao IBGE. A análise espacial foi realizada utilizando-se os programas GeoDaTM 1.6.7 e QGIS 2.16. Uma autocorrelação espacial positiva (I = 0,5953 e I = 0,4798; p < 0,05) foi encontrada, indicando a presença de agrupamentos entre os setores censitários em relação às taxas de incidência por hepatite B e C, respectivamente. Foram notificados 525 casos de hepatite B, distribuídos equitativamente quanto ao sexo e predominância da faixa etária de 35 a 49 anos. Quanto à taxa de incidência bruta, a média foi de 52,1 casos por 100.000 habitantes, e foram encontrados 50 setores censitários com padrão Alto-Alto, principalmente nos distritos Leste, Nordeste e Sul do município. Em relação à hepatite C, 177 casos foram notificados, com predominância em homens e faixa etária de 50 a 64 anos. Quanto à taxa de incidência bruta a média foi 18,7 casos por 100.000 habitantes. O padrão Alto-Alto foi encontrado em 35 setores censitários principalmente nos distritos Leste, Oeste, Nordeste e Sul. Os indicadores socioeconômicos relacionados de forma significativa e positiva com a hepatite B foram: outros tipos de moradia, renda do responsável entre até ½ e 2 salários mínimos (SM), renda per capita entre 2 e até mais de 10 SM e renda não declarada, lixo em terrenos ou com outra destinação, casas com 5 moradores, utilização de água de poço ou de outras fontes e casas sem banheiro, indicando relação com população mais vulneráveis socioeconomicamente. Para a hepatite C, a relação com o padrão socioeconômico apresentou-se diferentemente, onde houve associação significante e positiva com: rendas do responsável de 3 a 15 SM e renda per capita de 2 a 3 SM a 5 a 10 SM, água de poço, água outros e lixo outros. Associação significante e negativa foi obtida com as variáveis: casa própria, sem renda declarada, renda do responsável até ½ SM, ½ a 1 SM e 1 a 2 SM, renda per capita de ½ a 1 SM e sem renda declarada, água em rede, ‘3, 5, 8 e 10 moradores’ e lixo coletado, indicando que uma população de maior renda e mais diversificada é afetada. Para ambas as infecções, o nível de alfabetização do responsável não foi significativo. A hepatite B atingiu principalmente as populações de setores censitários com padrão socioeconômico mais pobre, o que não ocorreu necessariamente com a hepatite C. Conclui-se que, o município apresenta altas taxas de incidência de hepatite B e C, que suas distribuições apresentaram dependência espacial, determinado por fatores socioeconômicos da população. A pesquisa abre novas possibilidades de investigação epidemiológica sobre as hepatites virais, permitindo uma reflexão a respeito da atenção, prevenção e vigilância das hepatites virais em região de fronteira.
Farías, Adrián Alejandro. "Hepatitis C en Córdoba: Implicancias de la coinfección HIV/HCV y cambios locales en el perfil epidemiológico molecular." Doctoral thesis, Farías AA. Hepatitis C en Córdoba: Implicancias de la coinfección HIV/HCV y cambios locales en el perfil epidemiológico molecular [Internet]. Universidad Nacional de Córdoba, 2013 [citado el 13 de febrero de 2020]. Disponible en: https://rdu.unc.edu.ar/handle/11086/6732, 2013. http://hdl.handle.net/11086/6732.
Full text139 h. : il., 29 cm.
The hepatitis C virus (HCV) is considered one of the major causes of chronic hepatitis, cirrhosis and liver cancer. Co-infection with HIV accelerates the progression of liver disease, increases the efficiency of transmission of HCV by non-parental routes and has been associated with the decrease in the effectiveness of HAART. Worldwide, HCV distribution and its molecular pattern are markedly heterogeneous and are continuously changing, due to cultural changes, associated to new risk behaviors, as well as population movements. The aim of this work was to study the prevalence and genetic diversity of HCV infection in HIV co-infected individuals of Córdoba, evaluate its influence on antiretroviral therapy (HAART) and in HCV transmission, and identify possible changes in HCV genotype distribution pattern of Córdoba in the last 10 years. This study included the following samples obtained from patients of Córdoba: a) 349 serum samples from chronically infected individuals collected between 1999-2009; b) 86 serum samples from HCV/HIV co-infected patients obtained from a total of 558 HIV+ patients, collected in 2 periods between 2003-2007; and c) 37 biological fluid samples of HCV moninfected (n=21) and HCV/HIV co-infected individuals (n=16) [cervical swab (n=16), saliva (n=37), seminal plasma (n=21) and peripheral blood mononuclear cells (n=37)]. RT-nested PCR of the 5’ non-coding region (5’ NC) was used for HCV molecular detection. For genomic characterization and subsequent phylogenetic and viral evolution analysis, non-structural 5B and E1/E2 genomic regions were amplified and sequenced.
El virus de la Hepatitis C es considerado una de las principales causas de hepatitis crónica, cirrosis hepática y cáncer hepático. La coinfección con HIV acelera la progresión de la enfermedad hepática, aumenta la efectividad de la transmisión de HCV por vías no parenterales y ha sido asociada a la disminución de la efectividad de la terapia HAART. A nivel mundial, la distribución y el patrón molecular de HCV son marcadamente heterogéneos y se modifican continuamente debido tanto a cambios culturales, asociados a nuevas conductas de riesgo, como a movimientos poblacionales. El objetivo del presente trabajo fue estudiar la prevalencia y la diversidad genética de la infección por HCV en individuos coinfectados con HIV de Córdoba, evaluar su influencia en la terapia antiretroviral (HAART) y en la transmisión de HCV, y detectar posibles cambios en el patrón regional de distribución de genotipos en los últimos 10 años. En este estudio se incluyeron las siguientes muestras obtenidas de pacientes de Córdoba: a) 349 muestras de suero obtenidas de individuos crónicamente infectados por HCV colectados entre 1999-2009; b) 86 sueros de pacientes coinfectados HCV/HIV obtenidos de un total de 558 pacientes HIV+, colectados en dos periodos entre 2003-2007; y c) 37 muestras de fluidos biológicos de pacientes monoinfectados (n=21) y coinfectados HCV/HIV (n=16) [hisopado cervical (n=16), saliva (n=37), plasma seminal (n=21) y células mononucleares de sangre periférica (n=37)]. Para la detección molecular de HCV se utilizó RT-nested PCR de la región 5’ no codificante (5’ NC), y para la caracterización genómica y posterior análisis filogenético y evolución viral, se amplificaron y secuenciaron las regiones no estructural 5B y E1/E2.
Fil: Farías, Adrián Alejandro. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas Instituto de Virología Dr. José María Vanella; Argentina.
Lindsay, Christy. "Reading associations in England and Scotland, c.1760-1830." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:cfeb9aa2-6917-4356-8d11-b26237c795a5.
Full textHodes, Rebecca. "Siyayinqoba/Beat it! : HIV/AIDS on South African television c. 1999-2006." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670010.
Full textAbdesselam, Kahina. "Network Distribution and Respondent-Driven Sampling (RDS) Inference About People Who Inject Drugs in Ottawa, Ontario." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38744.
Full textBöckle, Ingrid. "Managerial perceptions of corporate social responsibility and social practices present at McDonalds South Africa." Thesis, Rhodes University, 2009. http://hdl.handle.net/10962/d1003088.
Full textTsakiropoulou, Ioanna Zoe. "The piety and charity of London's female elite, c.1580-1630 : the wives and widows of the aldermen of the City of London." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1b933cc5-905a-4be0-b10b-a20aec49997a.
Full textFredin, Rebecca Layton. "Perceptions of quality of medical care among consumers with schizophrenia who have a comorbid medical illness." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1330979750.
Full textHall, Arthur Lewis. "The representation of aspects of Afrikaner and British masculinity in the first season of Arende (1989) by Paul C Venter and Dirk de Villiers : a critical analysis." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/33360.
Full textDissertation (MA)--University of Pretoria, 2013.
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Visual Arts
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Telionis, Pyrros A. "Novel Applications of Geospatial Analysis in the Modeling of Infectious Diseases." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89432.
Full textDoctor of Philosophy
The focus of this work is called “spatial epidemiology”, which combines geography with public health, to answer the where, and why, of disease. This is a growing field, and you’ve likely seen it in the news and media. Have you ever seen a map of the United States turning red in some virus disaster movie? The real thing looks a lot like that. After the Ebola outbreak of 2014, public health agencies wanted to know where the next one might hit. Now that there is another outbreak, we need to ask where and how will it spread? What areas are hardest hit, and how bad is it going to get? We can answer all these questions with spatial epidemiology. Our work adds to two aspects of spatial epidemiology: niche modeling, and mobility. We use niche modeling to determine where we could find certain diseases, usually those that are spread by insects or animals. Consider Lyme disease, you get it from the bite of a tick, and the tick gets it from a white-footed mouse. But both the mice and ticks only live in certain parts of the country. With niche modeling we can determine where those are, and we can also guess at what makes those areas attractive to the mice and ticks. Is it winter harshness, summer temperatures, rainfall, and/or elevation? Is it something else? In Chapter 2, we show that you can extend this idea. Instead of just looking at where the disease is, what if we could guess how many people will get infected? What if we could do so, a year in advance? We show that this can be done, but we need a good idea of what the weather will be like next year. In Chapter 4, we show that you can do the same thing with hepatitis C. Instead of Lyme’s ticks and mice, hepatitis C depends on drug-use, unregulated tattooing, and unsafe sex. And like with Lyme, these things are only found in certain places. Instead of temperature or rainfall, we now need to find areas with drug-problems and poverty. But we can get an idea of this from the Census Bureau, and we can make a map of hepatitis C as easily as we did for Lyme. But hepatitis C spreads person-to-person. So, we need some idea of how people move around the area. This is where mobility comes in. Mobility is important for most public health work, from detecting outbreaks to estimating where the disease will spread next. In Chapter 3, we show how one could create a mobility model for a rural area where few maps exist. We also show how to use that model to guess where the next cases of Ebola will show up. In Chapter 4, we show how you could use mobility to improve outbreak and hotspot detection. We also show how it’s used to help estimate the number of cases in an area. Because that number depends on how many cases are imported from the surrounding areas. And the only way to estimate that is with mobility.
Reimers, Mia. "The glamour and the horror a social history of wartime, northwestern British Columbia, 1939-1945 /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0029/MQ62493.pdf.
Full textSerafim, Milena Pavan 1981. "A politica cientifica e tecnologica e a politica de inclusão social : buscando convergencia." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/286692.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Geociencias
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Resumo: Esta dissertação analisa duas políticas públicas ¿ a política científica e tecnológica (PCT) e a política de inclusão social (PIS) ¿ e tem como ponto de partida a constatação de que existe uma inadequada interação entre elas. Como objetivo, este trabalho busca produzir elementos cognitivos capazes de possibilitar sua interlocução e convergência. Como hipótese explicativa da inadequada interação entre as duas políticas e de sua incapacidade para viabilizar a inclusão social, apontamos para o modelo cognitivo usado para a sua elaboração. O entendimento que os atores envolvidos com as políticas - formuladores, gestores, estudiosos da PIS e da PCT, etc. ¿ têm da relação entre ciência, tecnologia e sociedade e, em particular, a predominância das concepções da neutralidade e do determinismo científico e tecnológico, que ocupa um papel central nesse modelo cognitivo, é a importante condicionante dessa situação. Para estudar essa inadequada interação, usamos o instrumental de Análise de Política, dada a sua capacidade de explicitar os aspectos políticos envolvidos no processo de elaboração das políticas públicas e como estes influenciam o seu conteúdo. É privilegiada a análise dos processos de identificação de prioridades, de conformação da agenda e de formulação da política, por entendermos que eles são importantes para identificar o modelo cognitivo das políticas e, no âmbito de nosso trabalho, caracterizar a inadequada interação entre as duas políticas. O estudo da trajetória das duas políticas revelou mudanças mais ou menos concomitantes, associadas às alterações do contexto que as envolve. No caso do período mais recente, embora o governo atual tenha proposto um estilo de desenvolvimento distinto do até então adotado, o modelo cognitivo das duas políticas não se alterou de forma significativa, uma vez que foram mantidas aquelas concepções acerca da C&T. Como proposta normativa, este trabalho concebeu o que denominamos de "Enfoque Científico-tecnológico para Inclusão Social" orientado a viabilizar a interação entre as duas políticas através da constituição de um modelo cognitivo baseado na crítica àquelas duas concepções
Abstract: This Master's dissertation is focused on the analysis of two important public policies: science and technology policy and social inclusion policy. The study is based on the perception that the interaction between the two policies is rather inadequate. It is thus directed to discussing elements that may be used toward stimulating the interaction and convergence of these two policies. As an explanatory hypothesis regarding this inadequate interaction and the constraint it represents for social inclusion, we point out to the cognitive model used in the elaboration of these two policies. The perception shared by those involved with this process ¿ policy makers, administrators, STP and SIP researchers, etc. ¿ regarding science and technology and their relation to society, and particularly the view on scientific and technological neutrality and determinism, which plays a pivotal role in this cognitive model, is the main cause of this situation. In order to study in detail this inadequate interaction between the two policies, the Policy Analysis framework is utilized, given its capability of unveiling political aspects that involve policy making and policy characteristics. The analytical tools for priority identification, agenda conformation and policy making are emphasized, due to their importance in allowing a more complete understanding of public policies, including the cognitive model that shapes them and the aspects of their interaction. The analysis of the trajectory of these two policies has revealed some significant changes, somewhat connected, that are associated to some broader contextual changes. Particularly in the more recent period, despite a new proposal for development from the current office, it is noted that the cognitive model of the two policies has not been significantly altered, due to the persistence of the views on scientific and technological neutrality and determinism. As a normative proposal, the ¿Cognitive Approach to Social Inclusion¿ is presented. It is directed towards allowing the interaction between the two policies through the construction of a cognitive model based on the criticism concerned the views on scientific and technological neutrality and determinism
Mestrado
Mestre em Política Científica e Tecnológica
Freitas, Junior Moacir de [UNESP]. "O industrial e o salário: a contribuição de Roberto Simonsen para os estudos sobre padrão de vida de trabalhadores no Brasil." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/104701.
Full textO intento desta tese é investigar a contribuição de Roberto Simonsen para o conhecimento e a melhora das condições de vida dos trabalhadores no Brasil. Nossa hipótese é a de que o intelectual contribuiu de maneira fundamental para que o tema das condições de vida dos trabalhadores, especialmente dos operários, fosse inserido em uma agenda mais ampla, a do nacional-desenvolvimentismo, para a qual também contribuiu de maneira significativa, conforme debateremos ao longo deste trabalho. A obra de Simonsen é ampla e aborda aspectos variados, que se estendem desde os problemas centrais de nossa história econômica e social até questões relativas ao associativismo empresarial. Optamos por este tema porque entendemos que Simonsen tinha uma especial atenção para o tema das condições de vida e entendia que a superação da pobreza era a chave para que o Brasil se tornasse um país desenvolvido economicamente. Entendemos e pretendemos demonstrar ao longo do trabalho que foi a partir da constatação da situação de carestia em que a classe trabalhadora vivia no Brasil que o autor desenvolveu seus importantes conceitos sobre a economia e sobre a necessidade da industrialização como forma de superação da pobreza, sendo o tema o centro de suas teorias, o cerne, o alicerce do qual partiu para erguer o corolário de ideias sobre o Brasil e o mundo que o consagraram como um pensador do Brasil
The intent of this thesis is to investigate the contribution of Roberto Simonsen, for knowledge and improvement of living conditions of workers in Brazil. Our hypothesis is that the intellectual contributed in a fundamental way to the theme of the living conditions of workers, especially workermens, was inserted into a broader agenda, that of national developmentalism, to which she also contributed significantly, as we will discuss throughout this work. The work of Simonsen is broad and covers various aspects, which extend from the central problems of our economic and social history to issues relating to business associations. We chose this theme because we believe that Simonsen had a special attention to the issue of living conditions and understand that overcoming poverty was the key for Brazil, to become a developed country economically. We understand and we intend to demonstrate over the work, that was based on the statement of the situation of famine in the working class lived in Brazil, that the author developed his important concepts, about the economy and about the need for industrialization as a means of overcoming poverty, and the subject at the center of their theories, the core, the foundation of which went to build the corollary ideas about Brazil and the world consecrated as a thinker of Brazil
Paterson, Craig. "Prohibition & resistance: a socio-political exploration of the changing dynamics of the southern African cannabis trade, c. 1850 - the present." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1002403.
Full textL, Potter Yvonne. "Progress, pubs and piety : Port Adelaide 1836-1915." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09php869.pdf.
Full textBrener, Loren Psychology Faculty of Science UNSW. "Implicit and explicit attitudes of health care workers and their injecting drug using clients with hepatitis C: is this related to treatment experiences?" 2007. http://handle.unsw.edu.au/1959.4/40603.
Full textThetford, H. Clare. "Reconceiving the Spoiled Female Identity: Childbearing and Motherhood among Women with Hepatitis C." Phd thesis, 2004. http://hdl.handle.net/1885/48208.
Full textParboosing, Raveen. "Clinical and epidemiological aspects of HIV and Hepatitis C virus co-infection in KwaZulu-Natal province of South Africa." Thesis, 2008. http://hdl.handle.net/10413/1005.
Full textThesis (M.Med.)-University of KwaZulu-Natal, Durban, 2008.
"Determination of the differential roles of wild-type and C-terminal truncated hepatitis B virus X protein in hepatocarcinogenesis and construction of inducible cells expressing truncated HBx." 2007. http://library.cuhk.edu.hk/record=b5896731.
Full textThesis (M.Phil.)--Chinese University of Hong Kong, 2007.
Includes bibliographical references (leaves 162-179).
Abstracts in English and Chinese.
Abstract --- p.i
Abstract in Chinese (摘要) --- p.ii
Acknowledgements --- p.iii
Table of Content --- p.iv
Abbreviations --- p.xi
List of Figures --- p.xiv
List of Tables --- p.xvii
Chapter CHAPTER 1 --- INTRODUCTION
Chapter 1.1 --- Hepatitis B Virus
Chapter 1.1.1 --- General information --- p.1
Chapter 1.1.2 --- Classification --- p.2
Chapter 1.1.3 --- Virus life cycle and genome --- p.3
Chapter 1.1.4 --- Hepatitis B virus X protein (HBx) --- p.7
Chapter 1.2 --- Enigmatic functions of HB --- p.x
Chapter 1.2.1 --- HBx as a transactivator --- p.10
Chapter 1.2.2 --- HBx as a cell cycle regulator --- p.12
Chapter 1.2.3 --- HBx as an apoptosis modulator --- p.13
Chapter 1.3 --- Etiology of HBV-mediated hepatocarcinogenesis --- p.14
Chapter 1.4 --- Clinical mutants of HBV --- p.16
Chapter 1.5 --- Hypothesis and aims of the research --- p.16
Chapter 1.6 --- Basis of Tet-On system --- p.18
Chapter CHPATER 2 --- EXPERIMENT MATERIALS
Chapter 2.1 --- Cell culture
Chapter 2.1.1 --- Cell-lines --- p.21
Chapter 2.1.2 --- Culture medium --- p.22
Chapter 2.1.3 --- Culture medium supplements --- p.23
Chapter 2.2 --- Reagents for subcloning
Chapter 2.2.1 --- Reagents for polymerase chain reaction (PCR) --- p.24
Chapter 2.2.2 --- Reagents for restriction enzyme digestion --- p.24
Chapter 2.2.3 --- Reagents for ligation --- p.25
Chapter 2.2.4 --- Reagents for electrophoresis --- p.25
Chapter 2.2.5 --- Reagents for E. coli DH5a preparation --- p.25
Chapter 2.2.6 --- Materials for bacterial culture work --- p.27
Chapter 2.3 --- Reagents for subcellular localization study
Chapter 2.3.1 --- Reagents for cell staining --- p.28
Chapter 2.3.2 --- Reagents for mounting slides --- p.29
Chapter 2.3.3 --- Materials for site-directed mutagenesis --- p.29
Chapter 2.4 --- Reagents for cell cycle analysis and cellular proliferation
Chapter 2.4.1 --- Reagents for cell cycle analysis --- p.29
Chapter 2.4.2 --- Reagents for cellular proliferation study --- p.30
Chapter 2.5 --- Reagents for protein expression study
Chapter 2.5.1 --- Cell lysis buffer --- p.30
Chapter 2.5.2 --- Reagents for SDS-PAGE --- p.30
Chapter 2.5.3 --- Reagents for Western blot --- p.33
Chapter 2.5.4 --- Antibodies --- p.34
Chapter 2.6 --- Reagents for gene expression study
Chapter 2.6.1 --- Reagents for RNA extraction --- p.36
Chapter 2.6.2 --- Reagents for first strand cDNA synthesis --- p.37
Chapter 2.6.3 --- Reagents for real-time PCR --- p.37
Chapter 2.7 --- Reagents for establishment of Tet-On inducible stable cell-lines
Chapter 2.7.1 --- Reagents for MTT assay --- p.38
Chapter 2.7.2 --- Reagents for selection of stable clones --- p.38
Chapter 2.8 --- Vectors used in the project
Chapter 2.8.1 --- Vectors for subcellular localization study --- p.39
Chapter 2.8.2 --- Vectors for establishment of Tet-on inducible cell-lines --- p.39
Chapter 2.9 --- Primers used in the project
Chapter 2.9.1 --- Primers used for subcloning --- p.42
Chapter 2.9.2 --- Primers used for site-directed mutagenesis --- p.43
Chapter 2.9.3 --- Primers used in real-time chain polymerase reaction --- p.43
Chapter CHAPTER 3 --- RESEARCH METHODS
Chapter 3.1 --- Subcloning of HBx and mutant genes into a green fluorescence protein (GFP) expression vector
Chapter 3.1.1 --- Amplification of HBxWt,HBxΔC44 and HBxAN60 genes --- p.45
Chapter 3.1.2 --- Purification of PCR products --- p.46
Chapter 3.1.3 --- Restriction enzyme digestion --- p.47
Chapter 3.1.4 --- Ligation of gene products with pEGFP-C 1 vector --- p.47
Chapter 3.1.5 --- Preparation of chemically competent bacterial cells E. coli strain DH5α --- p.47
Chapter 3.1.6 --- Transformation of the ligation product into competent cells --- p.48
Chapter 3.1.7 --- PCR confirmation of successful ligation --- p.48
Chapter 3.1.8 --- Small scale preparation of bacterial plasmid DNA --- p.49
Chapter 3.1.9 --- DNA sequencing of the cloned plasmid DNA --- p.50
Chapter 3.1.10 --- Large scale preparation of target recombinant plasmid DNA --- p.50
Chapter 3.2 --- Subcellular localization pattern study
Chapter 3.2.1 --- Cell transfection --- p.51
Chapter 3.2.2 --- Mitochondria and nucleus staining --- p.52
Chapter 3.2.3 --- Epi-fluorescence microscopy --- p.53
Chapter 3.2.4 --- Analysis of fluorescence images --- p.53
Chapter 3.2.5 --- In vitro site-directed mutagenesis --- p.53
Chapter 3.3 --- Cell cycle phase analysis with flow cytometry
Chapter 3.3.1 --- Cell transfection --- p.55
Chapter 3.3.2 --- Cell staining --- p.55
Chapter 3.3.3 --- Flow cytometry --- p.55
Chapter 3.4 --- Cellular proliferation quantification by BrdU proliferation assay
Chapter 3.4.1 --- Cell transfection --- p.57
Chapter 3.4.2 --- BrdU ELISA measurement --- p.57
Chapter 3.5 --- Protein expression
Chapter 3.5.1 --- Cell lysate collection --- p.58
Chapter 3.5.2 --- Quantification of protein samples --- p.59
Chapter 3.5.3 --- SDS-PAGE --- p.59
Chapter 3.5.4 --- Western blot --- p.60
Chapter 3.5.5 --- Western blot luminal detection --- p.60
Chapter 3.6 --- Gene expression
Chapter 3.6.1 --- Primer design --- p.61
Chapter 3.6.2 --- Cell transfection --- p.61
Chapter 3.6.3 --- RNA extraction --- p.61
Chapter 3.6.4 --- Reverse transcription for first strand complementary DNA (cDNA) --- p.63
Chapter 3.6.5 --- Quantitative real-time PCR --- p.63
Chapter 3.7 --- Establishment of Tet-On inducible stable cell-lines
Chapter 3.7.1 --- Subcloning of HBx gene into pTRE2 vector --- p.64
Chapter 3.7.2 --- Construction of WRL68/Tet-On stable cell-lines --- p.64
Chapter 3.7.3 --- Construction of WRL68/Tet-On HBx and mutants expression cell-lines --- p.68
Chapter 3.7.4 --- Characterization of Tet-On gene expression monoclones --- p.69
Chapter 3.8 --- Statistical analyses --- p.70
Chapter CHPATER 4 --- STUDY ON MITOCHONDRIA TARGETING
Chapter 4.1 --- Establishment of pEGFP-Cl-HBx and mutants constructs --- p.71
Chapter 4.2 --- Transactivation C-terminus domain is essential for granular localization --- p.73
Chapter 4.3 --- Wild-type HBx localizes in mitochondria --- p.76
Chapter 4.4 --- C-terminal transactivation domain is sufficient for mitochondria targeting --- p.79
Chapter 4.5 --- Mapping of the HBx region crucial for mitochondria targeting --- p.81
Chapter 4.6 --- The 111-117 amino acids in HBx do not work as a signal peptide --- p.83
Chapter 4.7 --- Site-directed mutagenesis identifies the key amino acid at 115 in HBx for mitochondrial targeting --- p.85
Chapter CHAPTER 5 --- CELL PROLIFERATION AND REGULATION
Chapter 5.1 --- Alteration of S-phase distribution in cell cycle --- p.88
Chapter 5.2 --- Analysis of DNA synthesis using BrdU proliferation ELISA --- p.92
Chapter 5.3 --- Differential molecular regulation of cell cycle --- p.94
Chapter 5.4 --- Regulation of the mRNA expression levels of cyclin-dependent kinases inhibitors p2raf/cipl and p27kipl --- p.98
Chapter CHAPTER 6 --- TRANSACTIVATION AND RAS/RAF/MAPK PHOSPHORYLATION
Chapter 6.1 --- Determination of p53-dependency of p21、vaf/cipl expression --- p.101
Chapter 6.2 --- Ras/Raf/MAPK pathway activation by HBx variants
Chapter 6.2.1 --- ERK1/2 phophorylation by HBx variants --- p.104
Chapter 6.2.2 --- ERK inhibition blocks the regulation effect on p53Wt and p21waf/cipl --- p.107
Chapter 6.3 --- Transactivation activity on oncogenes/ proto-oncogenes
Chapter 6.3.1 --- Effect on c-myc (NM´ؤ002467) mRNA expression --- p.109
Chapter 6.3.2 --- Effect on RhoC (NM_017744) and Rabl4 (NM´ؤ016322) mRNA expression --- p.112
Chapter CHAPTER 7 --- CONSTRUCTION OF TET-ON INDUCIBLE CELL-LINES
Chapter 7.1 --- Establishment of WRL/Tet-On monoclonal cell-lines Page
Chapter 7.1.1 --- Determination of geneticin selection dosage --- p.116
Chapter 7.1.2 --- Selection of the best WRL/TOn clone using luciferase assay --- p.118
Chapter 7.2 --- Establishment of inducible WRL/TOn/Gene monoclonal cell-lines
Chapter 7.2.1 --- Determination of hygromycin selection dosage --- p.120
Chapter 7.2.2 --- Selection of positive WRL/TOn/Gene clones with viral genes --- p.122
Chapter 7.3 --- Characterization of TOXDC1 cell-line
Chapter 7.3.1 --- Cell morphology --- p.125
Chapter 7.3.2 --- Growth pattern of TOXDC1 --- p.126
Chapter 7.3.3 --- HBxAC44 induced p21waf/cipl mRNA expression --- p.127
Chapter 7.3.4 --- Doxycycline concentration dependent HBxAC44 expression in TOXDC1 --- p.129
Chapter CHAPTER 8 --- DISCUSSION
Chapter 8.1 --- Selection of cell model
Chapter 8.1.1 --- Selection of cell models --- p.130
Chapter 8.1.2 --- Selection of truncation mutant --- p.131
Chapter 8.2 --- Differential sub-cellular localization of HBx and its variants
Chapter 8.2.1 --- Mechanisms of mitochondria targeting --- p.132
Chapter 8.2.2 --- Mitochondria as site of HBx-induced apoptosis --- p.134
Chapter 8.2.3 --- Stimulation of calcium release from mitochondria by wild-type HBx --- p.135
Chapter 8.3 --- Cell cycle distribution profiling and its regulations
Chapter 8.3.1 --- Cell cycle pattern and cell proliferation --- p.136
Chapter 8.3.2 --- Differential cell cycle molecular pathway activation --- p.138
Chapter 8.4 --- Ras/Raf/MAPK mediated transactivation by HBxWt and its mutants
Chapter 8.4.1 --- p53-mediated p21waf/cipl expression --- p.142
Chapter 8.4.2 --- ERK-mediated p21waf/cipl and wild-type p53 mRNA expression --- p.143
Chapter 8.4.3 --- Regulation of oncogenes/ proto-oncogenes expression --- p.147
Chapter 8.5 --- General discussions on differential effects of HBxWt and HBxAC44 --- p.149
Chapter 8.6 --- Establishment of Tet-On/HBxAC44 cell-line TOXDC1 --- p.153
Chapter 8.7 --- Conclusions --- p.154
Chapter 8.8 --- Future Prospects
Chapter 8.8.1 --- From mitochondria targeting to calcium signaling --- p.157
Chapter 8.8.2 --- Construction of a complete cell cycle regulation pathway --- p.158
Chapter 8.8.3 --- Elucidation of the transcriptional transactivation regulation --- p.159
Chapter 8.8.4 --- To make the best use of the Tet-on stable cell-line TOXDC1 --- p.159
Chapter 8.8.5 --- Study with other carboxy-terminal truncation mutants --- p.160
Chapter 8.8.6 --- In vivo study --- p.160
REFERENCES --- p.162
Buczek, Magdalena Marta. "Qualitative study of a primary care-based hepatitis C treatment program at a safety-net hospital." Thesis, 2017. https://hdl.handle.net/2144/23754.
Full textCabral, Naciely Manuela. "Structures of risk: lived experiences of multi-syndemic clustering in the greater Boston area." Thesis, 2017. https://hdl.handle.net/2144/23775.
Full text""去污名化"的政治: 中国乙肝携带者与公民社会组织的反歧视抗争." 2013. http://library.cuhk.edu.hk/record=b5549711.
Full text本文采用个案研究方法,以北京益仁平中心为主要研究对象,围绕 “乙肝"在中国的建构和重构过程,将研究聚焦于三个方面:第一,乙肝污名化过程以及国家、市场中的话语权;第二,反乙肝歧视维权运动的条件和动员机制;第三,“将‘乙肝’去除"中的政治和权力话语三角。
本文从社会运动理论中的资源动员、政治机会结构和框架理论出发解读中国乙肝携带者的维权运动;将运动中的微观景象与宏观社会结构结合起来,考察影响乙肝携带者维权运动的主要因素以及运动的动员机制。研究伊始分别从国家和市场两个领域审视乙肝歧视问题在中国的建构过程,阐明乙肝污名化是政府权威以及市场中医药商和医学权威共谋下的合力作用,从而为乙肝携带者反歧视抗争运动的后续研究选择一个合适的立足点。笔者在案例中发现,组织在维权运动中将乙肝携带者群体动员起来,采取有效的策略,充分利用其在资源获得方面的优势、建立乙肝维权组织网络、善于把握时机营造政治机会空间、并能够吸纳律师和媒体的专业力量是维权行动能取得成功的重要因素。
组织在维权行动中的话语框架对运动的发展至关重要。乙肝携带者群体对组织运动框架的认同是动员成功的基础;掌握定义“乙肝"的主动权、运动领袖的可信性、框架话语表达的日常化、与媒体的良好关系等策略有助于框架在动员中与参与者、旁观者产生共鸣;抗争精英通过话语框架为抗争活动提供合法性。
反乙肝歧视维权运动可以看作是一个“将‘乙肝’去除"的“去污名化"运动。一方面,中央政府与地方政府有着各自自主性利益;另一方面,乙肝携带者群体内部就抗争形式也难以统一,这两种分裂情况交叉形成了一个围绕“将‘乙肝’去除"的,以规则、效益和权利为话语的权力三角,支撑反歧视行动的抗争空间。权力三角的多变性决定去除“乙肝"的行动是有策略的、冒险的,但却相对稳定。
Hepatitis B Virus carriers (HBVers) have launched series social movements targeting at eliminating discriminations against HBVers in job market and promoting fair employment in recent decade of years. Why does nowhere match the HBV discrimination in such country like China? How is contentious politics possible when the powerless engage in struggles with power holders, like state and market in China? The thesis attempts to learn the intricacies of body politics with sociological approaches.
Yirenping, a NGO located in Beijing, is selected as research object in this case study. Concentrating on the political nature of the HBV confrontations, this thesis is comprised of three parts: first, the stigmatization of HBV in China; second, tactics and strategies that employed against the system of discrimination; third, the politics of “Removing HBV" and the power triangle among state, market and civil society.
The analysis of the HBV movement is informed by three sociological theories of social movements: resource mobilization, political opportunity structure and framing, meanwhile macro structure and micro interaction are combined. It is postulated that this disease discrimination in China occurs when confronting an entrenched stigmatization conjoined from both state and market dedicated to keeping the HBVers excluded and marginalized, which serves as a departure point for further analysis of the struggles for power against this discrimination. Resources mobilized, leaderships and organizations, networks among HBVers and outside supporters, strategies in mobilization positively facilitate the anti-discrimination movements. Utilizing the institutional advocacies as well as informal networks with officials, NPC & CPCCC delegates open more political opportunities within the preexisting political environment.
Framing is essential to the movement mobilization. Identifying closely with the visions and missions in movements, the self conceptualization of HBV-discrimination, charismatic leaders, the everyday narrative of the frame, as well as strategic media coverage help promoting resonance among movement participants and standers-by. Framing strategies provide legitimacy for HBV selves in collective movements.
Finally, the thesis came to the conclusion that anti-discrimination-against-HBVers social movements in China can be interpreted as a process of struggle to “Removing HBV" power. Central government and local ones have their autonomies and interests respectively, while weak but observed divisions in protesting strategies also exist within the HBVers, which shape a triangle of power struggles among the dominant and dominated groups. The power triangle is flexible, and the “Removing HBV" movements are strategic, risk-taking, while being routinized.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
郭娜.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.
Includes bibliographical references (leaves 137-156)
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstracts in Chinese and English.
Guo Nuo.
中文摘要 --- p.i
英文摘要 --- p.ii
引言 --- p.1
Chapter 第一章 --- 导论 乙肝:作为医学问题和作为社会问题 --- p.3
Chapter 1.1 --- 作为医学问题的乙型肝炎及其全球地理分布 --- p.3
Chapter 1.2 --- 乙型肝炎在中国 --- p.6
Chapter 1.3 --- 作为社会问题的乙肝歧视 --- p.8
Chapter 1.4 --- 研究方法 --- p.10
Chapter 1.5 --- 小结 --- p.14
Chapter 第二章 --- 研究问题与文献回顾 --- p.15
Chapter 2.1 --- 社会运动理论的发展脉络 --- p.16
Chapter 2.2 --- 认同与社会运动的动员 --- p.21
Chapter 2.3 --- 中国底层社会与维权抗争研究回顾 --- p.24
Chapter 2.4 --- 中国反乙肝歧视运动的分析框架 --- p.26
Chapter 2.5 --- 小结 --- p.34
Chapter 第三章 --- 政府与入职体检 --- p.35
Chapter 3.1 --- 新中国成立之初的公共卫生政策 --- p.35
Chapter 3.2 --- 中国人事制度改革和公务员职业声望 --- p.39
Chapter 3.3 --- 体检标准与强制乙肝检测 --- p.43
Chapter 3.4 --- 小结 --- p.47
Chapter 第四章 --- 市场话语权与定义“乙肝" --- p.49
Chapter 4.1 --- 市场中的虚假广告 --- p.50
Chapter 4.2 --- 体检经济 --- p.54
Chapter 4.3 --- 医药商与医学权威 --- p.56
Chapter 4.4 --- 小结 --- p.58
Chapter 第五章 --- 乙肝携带者的个人经验 --- p.61
Chapter 5.1 --- 疾病的社会建构 --- p.62
Chapter 5.2 --- 乙肝携带者的认知过程 --- p.66
Chapter 5.3 --- 乙肝携带者的抗争选择 --- p.68
Chapter 5.4 --- 小结 --- p.74
Chapter 第六章 --- 从个体经验到集体行动:公民社会的回应 --- p.76
Chapter 6.1 --- 从个人困境到集体行动 --- p.76
Chapter 6.2 --- 反乙肝歧视运动中的资源动员 --- p.80
Chapter 6.3 --- 反乙肝歧视组织网络 --- p.82
Chapter 6.4 --- 反乙肝歧视运动中的机会空间 --- p.86
Chapter 6.5 --- 小结 --- p.90
Chapter 第七章 --- 框架策略:反乙肝歧视运动中的动员 --- p.91
Chapter 7.1 --- 认同与社会运动 --- p.91
Chapter 7.2 --- 反乙肝歧视运动的行动框架 --- p.95
Chapter 7.3 --- 反乙肝歧视运动的动员策略 --- p.100
Chapter 7.4 --- 小结 --- p.107
Chapter 第八章 --- 身体的政治:将“乙肝"去除 --- p.108
Chapter 8.1 --- 权力的维度 --- p.108
Chapter 8.2 --- 反乙肝歧视行动的抗争轨迹 --- p.111
Chapter 8.3 --- 国家、市场与公民社会:将“乙肝"去除 --- p.116
Chapter 8.4 --- 小结 --- p.130
Chapter 第九章 --- 总结与讨论 --- p.131
参考文献 --- p.137
Chapter 附录A --- 访谈提纲 --- p.157
Chapter 附录B --- 64名被访者基本信息概况 --- p.160
致谢 --- p.162
Machado, Eduarda Sofia Rodrigues. "Suporte social, qualidade de vida e morbilidade psicológica em toxicodependentes com hepatite B e C." Master's thesis, 2012. http://hdl.handle.net/10400.14/13631.
Full textThe present study aims to assess the relationship between social support, life quality and psychological morbidity among drug users infected with hepatitis B and C. In evaluating three instruments were applied, the Satisfaction Scale Social Support, the Life Quality Questionnaire brief (WHOQOL - BREF) and the Hospital Anxiety and Depression Scale (HADS), a sample of 31 people, users of IDT Braga. The results of this study indicate that drug users diagnosed with hepatitis B or C perceives its high life quality as well as their social support network. However, there are differences in levels of anxiety and depression in individuals with different types of hepatitis, individuals with hepatitis B have higher levels of anxiety and individuals with hepatitis C experience higher levels of depression.