Journal articles on the topic 'Hemodialysis Patients Malaysia'

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1

Raduan, Nor Jannah Nasution, Mohd Razali Salleh, Ghazali Ahmad, and Zaleha Ismail. "Depression and Cognitive Impairment in Patients on Hemodialysis: A cross-sectional study." Environment-Behaviour Proceedings Journal 5, no. 15 (December 24, 2020): 185–92. http://dx.doi.org/10.21834/ebpj.v5i15.2468.

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Depression and cognitive impairment are the most common complications of patients on hemodialysis. The objective of this study is to identify contributing factors to depression and cognitive impairment in hemodialysis patients. This is a cross-sectional study involving 110 hemodialysis patients in Hospital Kuala Lumpur. The samples were recruited through universal sampling. Patients were assessed with the Beck Depression Inventory and Montreal Cognitive Assessment. This study found that 18.2% of patients had depression, and 48.2% had cognitive impairment. Factors associated with depression were unmarried status, low education level, and cognitive impairment. Factors associated with cognitive impairment were low education level, depression, and unemployment. Keywords: hemodialysis, depression, cognitive, ESRD eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5i15.2468.
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Mohamed Koya, Saiful NizamMV. "Management of phosphate abnormalities in hemodialysis patients: Findings from Malaysia." Saudi Journal of Kidney Diseases and Transplantation 30, no. 3 (2019): 670. http://dx.doi.org/10.4103/1319-2442.261343.

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3

Chan, Yoke Mun, Mohd Shariff Zalilah, and Sing Ziunn Hii. "Determinants of Compliance Behaviours among Patients Undergoing Hemodialysis in Malaysia." PLoS ONE 7, no. 8 (August 3, 2012): e41362. http://dx.doi.org/10.1371/journal.pone.0041362.

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Jeemaun, Jamizan. "The Association of Satisfaction Level with Vascular Accesses and Adherence to Treatment among Haemodialysis Patients in Malaysia." NeuroQuantology 20, no. 1 (January 31, 2022): 319–29. http://dx.doi.org/10.14704/nq.2022.20.1.nq22299.

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Introduction: End-stage renal disease (ESRD) requiring hemodialysis has shown an increasing trend in Malaysia. Vascular access (VA) dysfunction is among the primary reasons behind morbidity and mortality among ESRD patients. VA dysfunction exits in all three (3) types of available access: arteriovenous graft (AVG), arteriovenous fistula (AVF), and central venous catheter (CVC). In Malaysia, among the largest causes and the issues of failure in hemodialysis (HD) treatment is the lack of good vascular access (VA). The purpose of this study is to identify the level of satisfaction and the association of HD vascular access with adherence to treatment among hemodialysis patients. Methodology: This quantitative cross-sectional and observational study included 118 ESRD patients among selected Private Hospital in Malaysia. Comparison between access satisfaction and adherence across access type. One way ANOVA was conducted to see the mean difference between the three types of vascular access. Finding: The results shows, AVF was used by 52.3%, AVG by 27.9%, and CVC by 18.6% from overall patients. A one Way ANOVA shows a significant difference in satisfaction between the three types of vascular access with lowest mean score (showing highest satisfaction) in patients with AVG, and then followed by AVF, and CVC (27.84 vs 31.66 vs 44.29; P =.001). Conclusion: The findings of the study have shown that, patients with AVG access type experienced high satisfaction and high adherence to treatment among hemodialysis patients. Compared to the AVF, AVG have greatest advantages such as AVG suitable for patent’s with small or weak vein, especially among the diabetic patients.
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Md. Yusop, Nor Baizura, Chan Yoke Mun, Zalilah Mohd Shariff, and Choo Beng Huat. "Factors Associated with Quality of Life among Hemodialysis Patients in Malaysia." PLoS ONE 8, no. 12 (December 16, 2013): e84152. http://dx.doi.org/10.1371/journal.pone.0084152.

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Ng, Eileen Suk Ying, Poh Yoong Wong, Ahmad Teguh Hakiki Kamaruddin, Christopher Thiam Seong Lim, and Yoke Mun Chan. "Poor Sleep Quality, Depression and Social Support Are Determinants of Serum Phosphate Level among Hemodialysis Patients in Malaysia." International Journal of Environmental Research and Public Health 17, no. 14 (July 16, 2020): 5144. http://dx.doi.org/10.3390/ijerph17145144.

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Despite optimal control of serum phosphate level being imperative to avoid undesirable health outcomes, hyperphosphataemia is a highly prevalent mineral abnormality among the dialysis population. This study aimed to determine factors associated with hyperphosphatemia among hemodialysis patients in Malaysia. Multiple linear regression analysis was used to ascertain the possible factors that influence serum phosphate levels. A total of 217 hemodialysis patients were recruited. Hyperphosphatemia was prevalent. Only approximately 25% of the patients were aware that optimal control of hyperphosphatemia requires the combined effort of phosphate binder medication therapy, dietary restriction, and dialysis prescription. The presence of diabetes mellitus may affect serum phosphate levels, complicating dietary phosphorus management. Patients who were less depressive portrayed higher serum phosphate levels, implying intentional non-compliance. Better compliance on phosphate binder, longer sleep duration, and higher social support was associated with a lower level of serum phosphate. Despite sleep disturbance being one of the most prevalent and intense symptom burdens identified by hemodialysis patients, relatively few studies have addressed this issue. It is time to formulate sleep therapeutic interventions besides the encouragement of strong social support, hoping which many clinical outcomes including hyperphosphatemia can be better controlled among hemodialysis patients.
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Sham, Fatimah, Karina Abdul Wahid Pereira, Nurulhafizza Abdul Latif, and Ayat Al-Sawad. "Assessing Illness Acceptance and Quality of Life among the End Stage Renal Disease (ESRD) Patients Undergoing Hemodialysis." Environment-Behaviour Proceedings Journal 7, no. 20 (July 5, 2022): 203–11. http://dx.doi.org/10.21834/ebpj.v7i20.3458.

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Haemodialysis is the best treatment for the long-term survival of end-stage renal disease patients that requires the acceptance of illness, which can maintain patients' Quality of life. Three hundred thirty-seven hemodialysis patients were involved in this study, which reported the acceptance of illness was moderate and was lowest among the males. The Quality of life was good and supported by the emotional well-being, dialysis staff encouragement, social support, and the acceptance of illness. Multidisciplinary intervention should be targeted to address the physical status and disease-specific core aiming to reduce further health complications and improve Quality of life. Keywords: acceptance to illness; quality of life; hemodialysis, end-stage renal disease patients eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i20.3458
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GO, Z. L., S. Y. Yee, R. Yahya, and S. Bavanandan. "POS-620 Fluid Overload, Excessive Ultrafiltration and Intradialytic Hypotension Among Hemodialysis Patients in a Hospital-Based Hemodialysis Unit in Malaysia." Kidney International Reports 7, no. 2 (February 2022): S266. http://dx.doi.org/10.1016/j.ekir.2022.01.653.

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Interventional Radiology, Malaysian Society of. "MYSIR 2022 Virtual E-Abstract 2." Interventionalist Journal 2, no. 1 (March 31, 2022): 6–10. http://dx.doi.org/10.32896/tij.v2n1.6-10.

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1. A RED HERRING OF MEDIASTINAL LYMPHOMA 2. ACUTE SUBMANDIBULAR SIALADENITIS; A RARE COMPLICATION POST POSTERIOR FOSSA SURGERY 3. A COST ANALYSIS OF INTERVENTION RADIOLOGY RELATED PROCEDURES IN VASCULAR ACCESS FOR HEMODIALYSIS 4. A CASE SERIES OF SPONTANEOUS EXTRAPERITONEAL HEMORRHAGE IN COVID-19 PATIENTS IN MALAYSIA 5. CONCURRENT STENTING OF MALIGNANCY-RELATED SVC & PULMONARY ARTERY STENOSES : A CASE REPORT
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Ramatillah, DianaLaila, SyedAzhar Syed Sulaiman, and AmerHayat Khan. "Hepatitis C infection become a common issue among hemodialysis patients in a hemodialysis center Jakarta, Indonesia, and survival comparison of hemodialysis patients with hepatitis infection between two hemodialysis centers in Jakarta, Indonesia, and Penang, Malaysia." Journal of Global Infectious Diseases 10, no. 2 (2018): 37. http://dx.doi.org/10.4103/jgid.jgid_85_17.

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11

Lim, Cordelia-Kheng-May, Jun-Hao Lim, Imliya Ibrahim, Yoke-Mun Chan, Nor Fadhlina Zakaria, Rosnawati Yahya, and Zulfitri Azuan Mat Daud. "Bioelectrical Impedance Analysis Derived-Phase Angle as a Pragmatic Tool to Detect Protein Energy Wasting among Multi-Ethnic Hemodialysis Patients." Diagnostics 11, no. 10 (September 23, 2021): 1745. http://dx.doi.org/10.3390/diagnostics11101745.

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Protein-energy wasting (PEW) is a devastating metabolic derangement that leads to increased morbidity and mortality in hemodialysis (HD) patients. This study aimed to determine the diagnostic test accuracy of bioelectrical impedance analysis derived-phase angle (PhA) in detecting PEW among HD patients. This was a multi-centre, cross-sectional study conducted amongst 152 multi-ethnic HD patients in Klang Valley, Malaysia. PEW was assessed using the International Society of Renal Nutrition and Metabolism criteria as the reference method. PhA was measured using a multi-frequency bioelectrical impedance spectroscopy at 50 kHz. Multiple and logistic regressions were used to determine factors associated with PhA and PEW diagnosis, respectively. A receiver operating characteristics curve analysis was used to establish the gender-specific PhA cut-offs to detect PEW. PEW existed in 21.1% of the HD patients. PhA was found as an independent predictor of PEW (adjOR = 0.308, p = 0.001), with acceptable to excellent discriminative performance (adjAUCmale = 0.809; adjAUCfemale = 0.719). Male patients had higher PhA cut-off compared to female patients (4.26° vs. 3.30°). We concluded that PhA is a valid and pragmatic biomarker to detect PEW in multi-ethnic Malaysian HD patients and a gender-specific cut-off is necessary, attributed to the gender differences in body composition.
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Khor, Su Mee, Angel Wei Ling Goh, and Chee Ping Chong. "EVALUATION OF DIETARY PROTEIN AND PHOSPHATE INTAKE AMONG THE HEMODIALYSIS PATIENTS WITH HYPERPHOSPHATEMIA IN PENANG, MALAYSIA." Malaysian Journal of Medical Research 04, no. 01 (January 2, 2020): 1–8. http://dx.doi.org/10.31674/mjmr.2020.v04i01.001.

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13

Karunarathne, Hansani, Tilakavati Karupaiah, Pramod Khosla, and Smiti Gupta. "A Metabolomics Approach to Biomarker Discovery Reveals That Tocotrienols Have Potential Beneficial Impact on Maintenance Hemodialysis Population." Current Developments in Nutrition 6, Supplement_1 (June 2022): 30. http://dx.doi.org/10.1093/cdn/nzac047.030.

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Abstract Objectives Cardiovascular disease is considered major comorbidity in the maintenance hemodialysis (MHD) population. A dietary supplement such as tocotrienols have shown to improve cardiovascular health in these patients. In our study, we hypothesized that the tocotrienols may possess potential beneficial impacts on MHD patients by improving their metabolomic profile. Methods Changes in plasma metabolomic profile of the MHD patients with or without tocotrienol rich fraction (TRF) supplements (300 mg/day) for 12 months period on plasma metabolomic profile of the US (n = 85) and Malaysian (n = 80) MHD was investigated using 1H-NMR based metabolomics approach followed by Receiver Operating Characteristics (ROC) curve based biomarker model validation. Results Partial linear square discriminant analysis showed a significant difference in the metabolomic profile of the MHD patients between the placebo and the TRF supplemented groups over 12 months in both US and Malaysian cohorts. According to metabolite identification and quantification proline, 4-hydroxyproline, ornithine, glutamate, 4-aminobutyrate, 3-aminoisobutyrate, acetoacetate, and 3-hydroxybutyrate were found to be significantly (p < 0.05) altered between the placebo group and TRF groups over 12 months. The biomarker models created using these key metabolites had shown good predictive accuracy (Area under the ROC curve > 0.8) in both cohorts with high sensitivity (79% and 78%) and specificity (84% and 80%) in the US and Malaysian cohorts, respectively. Further model validation relied on the permutation test with 1000 permutations (p < 0.001), validating the predictive ability of the created biomarker models in both cohorts. The biomarker meta-analysis revealed that trans-4-hydroxyproline, proline, acetoacetate, ornithine, 3-hydroxybutyrate, 3-aminoisobutyrate, and glutamate had similar expression patterns in both cohorts. Conclusions Metabolites linked to arginine and proline metabolism and synthesis and degradation of ketone bodies pathways were altered in MHD patients over 12 months. TRF modulated these changes in a favorable direction, indicating the potential beneficial impact of TRF supplements in these patients. These metabolites may serve as biomarkers for kidney disease and/or for evaluating the efficacy of TRF supplementation in MHD patients. Funding Sources PEMANDU, Malaysia
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14

Md Ali, Mohammad Syafiq, Zu-Wei Yeak, Ban-Hock Khor, Sharmela Sahathevan, Ayesha Sualeheen, Jun-Hao Lim, Nurul Iman Hafizah Adanan, et al. "HD-FFQ to Detect Nutrient Deficiencies and Toxicities for a Multiethnic Asian Dialysis Population." Nutrients 12, no. 6 (May 28, 2020): 1585. http://dx.doi.org/10.3390/nu12061585.

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A rapid and reliable tool appropriate to quantifying macronutrient and micronutrient intakes in diets consumed by Malaysian hemodialysis (HD) patients is lacking. We aimed to develop and validate a novel HD-food frequency questionnaire (HD-FFQ) to assess habitual nutritional intakes of HD patients with diverse ethnic backgrounds. This study was conducted in three phases. In Phase I, a HD-FFQ comprising 118 food items was developed using 3-day diet recalls (3DDR) from 388 HD patients. Phase II was the face and content validation using the Scale-Content Validity Index (S-CVI). After successfully developing the FFQ, Phase III tested relative validation against a reference method, the 3DDR. Results from Phase III showed that the mean difference for absolute intakes of nutrients assessed by HD-FFQ and 3DDR were significant (p < 0.05). However, there was a significant correlation between the HD-FFQ and reference method ranging from 0.35–0.47 (p < 0.05). Cross-quartile classification showed that <10% of patients were grossly misclassified. In conclusion, the HD-FFQ has an acceptable relative validity in assessing and ranking the dietary intake of the HD patients in Malaysia.
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Singh, Birinder Kaur Sadu, Ban-Hock Khor, Sharmela Sahathevan, Abdul Halim Abdul Gafor, Enrico Fiaccadori, Karuthan Chinna, See-Hoe Ng, and Tilakavati Karupaiah. "Barriers and Facilitators to Intradialytic Parenteral Nutrition Implementation Targeting Protein Energy Wasting in Malaysian Hemodialysis Patients." Healthcare 10, no. 10 (October 20, 2022): 2090. http://dx.doi.org/10.3390/healthcare10102090.

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The capacity to deliver intradialytic parenteral nutrition (IDPN) for patients on hemodialysis (HD) diagnosed with protein energy wasting (PEW) in low resource settings is unknown. This study aimed to examine the extent of IDPN practice in HD units in Malaysia, and its implementation to treat PEW. We surveyed pharmacists (n = 56), who are central to parenteral nutrition delivery in Malaysia including IDPN. Seventeen healthcare stakeholders engaging with the Promoting Action on Research Implementation in Health Services (PARIHS) framework used the Likert scale to rate survey outcomes on IDPN implementation to treat PEW, according to the Evidence, Context, and Facilitation elements. IDPN for HD patients was available in 28 of 56 hospitals providing parenteral nutrition services, with only 13 hospitals (23.2%) providing IDPN to outpatients. Outpatient treatment was concentrated to urban locations (12/13) and significantly associated (p < 0.001) with resident nephrologists. The Evidence domain was rated poorly (2.18 ± 0.15) pertaining to IDPN indication when the oral spontaneous intake was ≤20 kcal/kg/day. The Context domain indicated good adherence to international best practice relating to IDPN administration (4.59 ± 0.15) and infusion time (4.59 ± 0.12). Poor adherence was observed in the Facilitation domain on ’Access to pharmacist and dietitian at HD units’ (2.65 ± 0.21) and ’Access to continuous medical education on managing PEW patients on HD’ (2.53 ± 0.15). The IDPN outpatient service was concentrated to urban hospitals with greater manpower resources. The PARIHS evaluation on IDPN implementation to treat PEW revealed facilitators in good practice adherence for prescribing and administration of IDPN but highlighted major barriers relating to IDPN indication and nutrient calculation.
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Lee, Soik Fun, and Chee Ping Chong. "The influence of beliefs about medicines on medication nonadherence among hemodialysis patients: a multicenter study from Malaysia." Eastern Journal Of Medicine 27, no. 3 (2022): 446–57. http://dx.doi.org/10.5505/ejm.2022.57804.

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Abdul Manaf, Mohd Rizal, Naren Kumar Surendra, Abdul Halim Abdul Gafor, Lai Seong Hooi, and Sunita Bavanandan. "Dialysis Provision and Implications of Health Economics on Peritoneal Dialysis Utilization: A Review from a Malaysian Perspective." International Journal of Nephrology 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/5819629.

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End-stage renal disease (ESRD) is managed by either lifesaving hemodialysis (HD) and peritoneal dialysis (PD) or a kidney transplant. In Malaysia, the prevalence of dialysis-treated ESRD patients has shown an exponential growth from 504 per million population (pmp) in 2005 to 1155 pmp in 2014. There were 1046 pmp patients on HD and 109 pmp patients on PD in 2014. Kidney transplants are limited due to lack of donors. Malaysia adopts public-private financing model for dialysis. Majority of HD patients were treated in the private sector but almost all PD patients were treated in government facilities. Inequality in access to dialysis is visible within geographical regions where majority of HD centres are scattered around developed areas. The expenditure on dialysis has been escalating in recent years but economic evaluations of dialysis modalities are scarce. Evidence shows that health policies and reimbursement strategies influence dialysis provision. Increased uptake of PD can produce significant economic benefits and improve patients’ access to dialysis. As a result, some countries implemented a PD-First or Favored Policy to expand PD use. Thus, a current comparative costs analysis of dialysis is strongly recommended to assist decision-makers to establish a more equitable and economically sustainable dialysis provision in the future.
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Lim, J. H., N. F. Zakaria, K. Chinna, T. Karupaiah, and Z. A. M. DAUD. "SUN-313 EXPLORING THE RELATIONSHIPS BETWEEN HEALTH LITERACY, DIETARY ADHERENCE AND ITS MEDIATORS IN HEMODIALYSIS PATIENTS IN MALAYSIA." Kidney International Reports 4, no. 7 (July 2019): S290. http://dx.doi.org/10.1016/j.ekir.2019.05.720.

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Shukri, Madihah, Mohd Azman Mustofai, Md Aris Safree Md Yasin, and Tuan Sharipah Tuan Hadi. "Burden, quality of life, anxiety, and depressive symptoms among caregivers of hemodialysis patients: The role of social support." International Journal of Psychiatry in Medicine 55, no. 6 (March 26, 2020): 397–407. http://dx.doi.org/10.1177/0091217420913388.

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Objective The purpose of this study was to determine how burden and quality of life predict anxiety and depressive symptoms among caregivers of hemodialysis patients. Social support was included in the model as a proposed moderator in the above relationships. Methods This cross-sectional study involved 340 caregivers of chronic kidney patients undergoing hemodialysis. The setting was in Terengganu, Malaysia. The caregivers completed the measures of caregiving burden, quality of life, social support, and symptoms of anxiety and depression. Results About 28.8% and 52.4% of caregivers showed clinically moderate levels of anxiety and depressive symptoms, respectively. Furthermore, 35.9% and 3.8% of them showed clinically high levels of anxiety and depressive symptoms, respectively. Analyses showed that general quality of life was a significant predictor of both anxiety and depressive symptoms. Burden and psychological domains of quality of life significantly predicted anxiety. In addition, a lack of social support was a determinant of depressive symptoms. Evidence suggested that social support moderated the burden–anxiety relationship. Specifically, caregivers with low levels of social support showed more elevated levels of anxiety symptoms when their burden was higher. Conclusion There is an urgent need for early detection to initiate prompt treatment in this population. The study provides some important insights into offering comprehensive intervention to help caregivers cope more effectively through the provision of sufficient social support to buffer the effects of caregiving burden and improve mental health.
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Ramatillah, Diana Laila, Syed Azhar Syed Sulaiman, Amer Hayat Khan, Dato Ong Loke Meng, and Markum M. "Probability of Dying and Survival Analysis of Diabetic and/Hypertensive Patients Who Undergone Hemodialysis with Heart Disease Complication: A Comparison between a Hemodialysis Center Jakarta, Indonesia and Penang, Malaysia." Journal of Cardiovascular Disease Research 9, no. 1 (April 1, 2018): 24–27. http://dx.doi.org/10.5530/jcdr.2018.1.6.

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Lim, Jun Hao, Cordelia Kheng May Lim, Imliya Ibrahim, Jazlina Shahrul, Mohd Hazli Mohd Zabil, Nor Fadhlina Zakaria, and Zulfitri Azuan Daud. "Development of a Personalized Apps to Inculcate Dietary Self-Management for Maintenance Hemodialysis Patients: A Need Analysis." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1325. http://dx.doi.org/10.1093/cdn/nzaa059_042.

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Abstract Objectives Dietary non-adherence is highly prevalent among maintenance hemodialysis (HD) patients resulting in multitudes health complications and poor treatment outcomes. Given high penetration of smartphone, well-designed mobile health apps emerged as a potential tool to empower HD patients with dietary self-management skills. This need analysis study determined the perception and expectation of patients and dietitians on the features and the use of apps in dialysis care to foster development of evidence-based renal diet apps. Methods This was a mixed-method study with concurrent triangulation design. The quantitative arm involved HD patients (n = 184) through face-to-face interview and dietitians (n = 120) via anonymous online survey. While the qualitative arm consisted of 10 in-depth interviews (HD patients) and 8 email interviews (dietitians). Descriptive and thematic analyses were used, and the results were compared. Results A total of 69.6% of HD patients owned a smartphone. More than half (53.9%) of the smartphone users had the experience of searching health information especially nutrition-related topics (91.3%). Majority of them (78.9%) perceived renal diet apps as very important and were willing to use (80.5%). They agreed that renal diet apps can help them in preventing nutrition complications (82.0%), planning menu (78.9%) and monitoring nutrient intakes (82.8%). In the context of practising dietitians, 60.8% aware of the existence of renal diet apps but only 38.3% of them would recommend existing renal diet apps to their patients due to lack of local content (42.5%) and unsure credibility (37.5%). Most of them (88.3%) perceived that local-based renal diet app is needed and agreed that it can enhance dietetics care in HD population (90.8%). Top features anticipated by both patients and dietitians included plan or order, tailored assistance, usability and tracker. Conclusions Dietary self-management via mobile health apps seems to be feasible in the dialysis population given the high smartphone penetration, strong desire to use and positive perceptions from patients and dietitians. Features valued by patients and dietitians will be integrated into the design of the apps to promote acceptance and usage. Funding Sources This project is funded by the internal grant of Universiti Putra Malaysia (Inisiatif Putra Muda).
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Lim, Jun-Hao, Karuthan Chinna, Pramod Khosla, Tilakavati Karupaiah, and Zulfitri Azuan Mat Daud. "Understanding How Nutrition Literacy Links to Dietary Adherence in Patients Undergoing Maintenance Hemodialysis: A Theoretical Exploration using Partial Least Squares Structural Equation Modeling." International Journal of Environmental Research and Public Health 17, no. 20 (October 14, 2020): 7479. http://dx.doi.org/10.3390/ijerph17207479.

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Dietary non-adherence is pervasive in the hemodialysis (HD) population. Health literacy is a plausible predictor of dietary adherence in HD patients, but its putative mechanism is scarcely studied. Thus, this study aimed to establish the causal model linking nutrition literacy to dietary adherence in the HD population. This was a multi-centre, cross-sectional study, involving 218 randomly selected multi-ethnic HD patients from nine dialysis centres in Klang Valley, Malaysia. Dietary adherence and self-management skills were assessed using validated End-Stage Renal Disease Adherence Questionnaire and Perceived Kidney/Dialysis Self-Management Scale, respectively. Validated self-developed scales were used to gauge nutrition literacy, dietary knowledge and Health Belief Model constructs. Relationships between variables were examined by multiple linear regressions and partial least squares structural equation modeling. Limited nutrition literacy was evident in 46.3% of the HD patients, associated with older age, lower education level, and shorter dialysis vintage. Dietary adherence rate was at 34.9%. Nutrition literacy (β = 0.390, p < 0.001) was an independent predictor of dietary adherence, mediated by self-efficacy (SIE = 0.186, BC 95% CI 0.110–0.280) and self-management skills (SIE = 0.192, BC 95% CI 0.103–0.304). Thus, nutrition literacy-enhancing strategies targeting self-efficacy and self-management skills should be considered to enhance dietary adherence in the HD population.
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Ng, C. R., and W. S. Wong. "AB1386 A SURVEY ON ACCEPTANCE OF COVID-19 VACCINATION AMONG PATIENTS WITH RHEUMATIC DISEASES -A SINGLE CENTER EXPERIENCE IN MALAYSIA." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1798.1–1798. http://dx.doi.org/10.1136/annrheumdis-2022-eular.371.

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BackgroundAccording to Statista, 78.5% of the population in Malaysia have completed their vaccination as of 6th january 2022 [1].The acceptance of patients with rheumatic diseases on Covid-19 vaccination is crucial in the long term protection against Covid-19 infection. We conducted a survey to determine the acceptance of Covid-19 vaccination amongst patients with underlying rheumatic disease.ObjectivesTo find out the reasons of vaccination refusal amongst rheumatology patients.MethodsThis was an interview survey. All rheumatology patients who were follow up in rheumatology clinic Hospital Sultan Ismail, Malaysia from 26th April 2021 to 25th July 2021 (total 3 months) were interviewed. Demographic and diagnosis of the patients were collected.ResultsA total of 952 patients were identified. 83.7% of them were female patients (797/952) and majority of them were Malay (46.4%). This was followed by Chinese (36.1%), Indian (16.3%) and others (1.2%). The mean age group was 48 (range from 13 -85).97.6% of the respondents were categorized as having inactive disease during the interview sessions.36.6% of the patients were diagnosed to have rheumatoid arthritis and 29.1% of them were having systemic lupus erythematosus. These were followed by psoriatic arthritis (10.9%), mixed connective tissue disease (5.5%), systemic sclerosis (2.9%), gout (2.6%), Sjogren syndrome (1.9%), ankylosing spondylitis (1.6%), myositis (1.5%), vasculitis (1.3%), osteoarthritis (1.2%), antiphospholipid syndrome (0.9%), non-specific arthralgia (0.8%), juvenile idiopathic arthritis (0.8%), seronegative spondyloarthropathy (0.8%), undifferentiated connective tissue disease (0.7%), adult onset still’s disease 0.5%) and others (< 0.5% each for Ig G 4 related disease, soft tissue rheumatism and fibromyalgia).87.3% of them were keen or have already received Covid-19 vaccination. 12.7% of them were not keen for the vaccination with various reasons.48.8% of them were worrying about worsening clinical condition, 12.4% of them were not keen as they concerned about side effects (3 worry about fever, 1 worry about hepatitis, 1 for nausea, 1 for dizziness, 1 for breathlessness, and 7 for non-specific reasons). 10.7% of them were not keen due to pregnancy, 5.79% of them were not keen as worried about allergic reactions, 4.9% of them were worrying about sudden cardiac death, 4% were not keen as on chemotherapy treatment, 3 % of them doubted the efficacy of vaccination, 2.5% were not keen as they worried about heart disease, 2.5% worried about increase risks of infection and others (2 for old age, 2 for thrombotic event, 2 for drug interaction and 1 patient due to hemodialysis).ConclusionThe overall acceptance rate of Covid-19 vaccination amongst patients with rheumatic diseases is very encouraging with the percentage of >85% despite of lacking knowledge about vaccine Covid-19. This result can assist our Ministry of Health to plan for future battle to improve vaccine uptake that hopefully can lead to herd immunity against COVID-19 infection. More counseling sessions are required to clear up the doubts of vaccination and increase the vaccination rate amongst rheumatic patients.References[1]R. Hirschmann, Vaccination rate against Covid-19 Malaysia 2022, by state, Statista. Jan 7, 2022.Disclosure of InterestsNone declared
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Gillani, Syed Wasif, Irfan Altaf Ansari, Hisham A. Zaghloul, Mohi Iqbal Mohammad Abdul, Syed Azhar Syed Sulaiman, Mirza R. Baig, and Hassaan Anwar Rathore. "Women with Type 1 Diabetes Mellitus: Effect of Disease and Psychosocial-Related Correlates on Health-Related Quality of Life." Journal of Diabetes Research 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/4079087.

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Background. This study is aimed at investigating the various disease-specific and health-related psychosocial concepts of HRQOL among insulin-dependent diabetes mellitus (IDDM) and understanding the gender differences in HRQOL among IDDM patients. Methods. A cross-sectional observational study was conducted to assess the effect of health-related and psychosocial correlates on HRQOL of IDDM patients in Penang, Malaysia. The participants were recruited from five governmental diabetic clinics. Patients with insulin use only, IDDM diagnosed at least 1 year earlier, were identified from clinical registers. The sample was then age stratified for 20–64 years, and severe complications (e.g., end-stage renal failure, hemodialysis, and liver cirrhosis) were excluded; a total of 1003 participants were enrolled in the study. Multivariate regression analysis was used to predict the response. Results. A total of 853 (100%) participants were enrolled and completed the study. Women exhibited significantly higher/better mental health (p<0.013) and health perception scores (p<0.001) despite high prevalence of impaired role (49.2%), social (24.2%), and physical (40.5%) functionings as compared to men. Women with longer diabetes exposure and uncontrolled glycemic levels (HbA1c) have poorer HRQOL. Availability of social support showed no significant association with either HRQOL or diabetes distress levels. Diabetes distress levels remained not associated with social support. Women also showed significantly higher association with health perception (15% versus 13% men, p<0.001) and mental health (13% versus 11% men, p<0.001) in diabetes-specific psychosocial factors. Thus, among women alone, diabetes-related specific and psychosocial factors explained 15% and 13% of variations in HRQOL extents, respectively. Conclusion. Women exhibit extensive and significant patterns with health-related factors and diabetes-specific psychosocial factors (self-efficacy, social support, and DLC) to improve HRQOL. Also, women have significantly high reported distress levels and low social functioning compared to men.
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Karupaiah, Tilakavati, Chee Siew Swee, and Ruzana Abdullah. "Developing a nutrition education package for Malaysian hemodialysis patients." Journal of Renal Nutrition 11, no. 4 (October 2001): 220–27. http://dx.doi.org/10.1016/s1051-2276(01)70041-6.

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Karupaiah, Tilakavati, Chee Siew Swee, and Ruzana Abdullah. "Developing a nutrition education package for Malaysian hemodialysis patients." Journal of Renal Nutrition 11, no. 4 (October 2001): 220–27. http://dx.doi.org/10.1053/jren.2001.26987.

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Rehman, Inayat U., Pauline SM Lai, Lim S. Kun, Learn H. Lee, Kok G. Chan, and Tahir M. Khan. "Chronic Kidney Disease‐Associated Pruritus and Quality of Life in Malaysian Patients Undergoing Hemodialysis." Therapeutic Apheresis and Dialysis 24, no. 1 (July 24, 2019): 17–25. http://dx.doi.org/10.1111/1744-9987.12862.

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Cheng, Ignatius K. P. "Peritoneal Dialysis in Asia." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 16, no. 1_suppl (January 1996): 381–87. http://dx.doi.org/10.1177/089686089601601s73.

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The socioeconomic status of Asian countries is diverse, and government reimbursement policies for treatment of patients suffering from end-stage renal disease (ESRD) vary greatly from one country to another. Both of these factors have a major impact not only on the choice of treatment for ESRD but also on the utilization of peritoneal dialysis (PD) in this region. Based on the data collected from 11 representative Asian countries, several observations can be made. First, the treatment rates for ESRD in these countries correlated closely with their gross domestic product (GDP) per capita income. Second, the PD utillzation rate appeared to have a biphasic relationship with the GDP per capita income and treatment rate, in that countries with the highest and the lowest treatment rates tended to have lower PD utilization rates, whereas countries with modest treatment rates tended to have higher PD utilization rates. The reason for low PD utilization in countries with the highest treatment rates differs from that in countries with low treatment rates. In the former, because of full government reimbursement, there is little physician incentive to introduce PD as an alternative form of ESRD treatment to incenter hemodialysis (HD), whereas in the latter, the complete lack of government reimbursement prevents the introduction of PD as a form of treatment. This pattern is likely to change in the future because, of the 11 countries surveyed, all except Thailand have recorded a growth rate which is higher for PD than HD over the last three years. The rate of utilization of different PD systems varies greatly among different Asian countries. Automated PD has yet to gain popularity in Asia. Conventional straightline systems remain the dominant PD systems in use in Hong Kong, Korea, Thailand, and the Philippines, while in Malaysia and Singapore UV germicidal connection devices are most popular. However, in all these countries there has been a progressive shift over the last three years from the straight-line systems with or without germicidal connection devices to the disconnect systems. In China and India, where PD has been introduced only recently, the disconnect systems are used almost exclusively. The disconnect systems are also the most popular systems in use in Japan and Taiwan. As data concerning the costeffectiveness of different PD systems become available, it is likely that the trend towards a more liberal use of disconnect systems will continue in the future. The usage of low calcium peritoneal dialysate and the average number of daily CAPD exchanges also vary among the Asian countries. Low calcium peritoneal dialysate has been introduced only in Japan, Hong Kong, and Singapore, with the highest utilization rate (90%) recorded in Singapore. The Philippines had the lowest average number of daily peritoneal exchanges (6 L) among the countries surveyed, followed by Hong Kong (6.4 L), China and Indonesia (7 L), and the rest (8 L). The use of a lower number of exchanges was introduced in some countries, initially, mainly as a cost-saving measure based on the assumption that Asians are of small body build. The justification for the continued use of a lower number of exchanges among Asian patients is debatable, but is supported by the acceptable, long-term clinical outcome of patients given this form of dialysis prescription. It is suggested that long-term prospective studies on dialysis adequacy and clinical outcome should be done in different ethnic groups in Asia to see if the similar guidelines with regard to dialysis adequacy can be applied uniformly to Orientals and Caucasians.
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KARUPAIAH, T., A. Sualeheen, B. H. Khor, S. Sahathevan, Z. A. Mat Daud, K. Chinna, A. H. Abdul Gafor, G. V. Balasubramaniam, M. S. Md Ali, and P. Khosla. "MON-100 DIETARY PHOSPHATE INTAKE PATTERNS IN MALAYSIAN HEMODIALYSIS PATIENTS: UNDERSTANDING DETERMINANTS OF PATIENT BEHAVIORS." Kidney International Reports 4, no. 7 (July 2019): S345. http://dx.doi.org/10.1016/j.ekir.2019.05.890.

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Mohd Fadzli, Nur Fatin Aqilah, Ali Aminuddin Mohd Rasani, and Soon Lean Keng. "Assessing the financial burden of hemodialysis treatment in Malaysia." Belitung Nursing Journal, October 7, 2021. http://dx.doi.org/10.33546/bnj.1804.

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Background: Patients with chronic kidney disease (CKD) spend substantial money on hemodialysis (HD) treatment. The growing intersection between socioeconomic status and financial burden represents an emerging challenge to the CKD community. Objective: This study assessed the financial burden of HD treatment on patients at a Malaysian tertiary teaching hospital. Methods: A cross-sectional study was carried out in the HD unit at a Malaysian tertiary teaching hospital from January to February 2021. Patients undergoing HD were purposively selected. A self-administered questionnaire was used to collect data on socio-demographic, finances, the patient's health history, treatment costs, and healthcare utilization. In addition, Pearson Chi-Square tests were used to analyze the data. Results: A total of 100 patients receiving HD treatment were included in the study. The mean age was 62.06 years (SD = 27.50), with 52% reporting moderate financial burdens. The financial burden was associated with employment status, salary, and income class among HD patients (p <0.05). Conclusion: Evidence showed a large proportion of Malaysian patients receiving HD treatment came from the B40 income bracket. The findings indicate that financial burdens can impact HD patients and are related to employment status, salary, and income class. Therefore, the ability to identify HD patients' financial needs is critical in nursing practice.
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Nasution Raduan, Nor Jannah, Nur Faizah Ali, Emmy Amalia, and Mohd Razali Salleh. "Factors Contributing to Depression and Cognitive Impairment Among Patients on Hemodialysis." Journal of ASIAN Behavioural Studies 6, no. 19 (September 12, 2021). http://dx.doi.org/10.21834/jabs.v6i19.389.

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Depression and cognitive impairment are the most common complications of patients on hemodialysis. The objective of this study is to identify contributing factors to depression and cognitive impairment in hemodialysis patients. This is a cross-sectional study involving 110 hemodialysis patients in Hospital Kuala Lumpur. The samples were recruited through universal sampling. Patients were assessed with Beck Depression Inventory and Montreal Cognitive Assessment. This study found that 18.2% patients had depression and 48.2% had cognitive impairment. Factors associated with depression were unmarried status, low education level and cognitive impairment. Factors associated with cognitive impairment were low education level, depression and unemployment. Keywords: hemodialysis, depression, cognitive, ESRD eISSN 2514-7528 © 2021 The Authors. Published for AMER ABRA CE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians / Africans / Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/jabs.v6i19.389
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Ho, Ling Ling, Yoke Mun Chan, and Zulfitri ‘Azuan Mat Daud. "Dietary Factors and Sleep Quality Among Hemodialysis Patients in Malaysia." Journal of Renal Nutrition, April 2021. http://dx.doi.org/10.1053/j.jrn.2021.02.003.

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Khan, Amjad, Amer Hayat Khan, Azreen Syazril Adnan, Syed Azhar Syed Sulaiman, Saima Mushtaq, Nafees Ahmad, and Irfanullah Khan. "Hypertension control among euvolemic hypertensive hemodialysis patients in Malaysia: a prospective follow-up study." Journal of Pharmaceutical Policy and Practice 12, no. 1 (May 14, 2019). http://dx.doi.org/10.1186/s40545-019-0169-y.

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Abdul Rahman, Siti Nurul Fazlin, Hairul Aini Hamzah, and Mohammed Imad Mustafa. "Existence of Occult Hepatitis C virus Infection in Local Haemodialysis Setting." IIUM Medical Journal Malaysia 17, no. 1 (December 14, 2018). http://dx.doi.org/10.31436/imjm.v17i1.848.

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Introduction: Among chronic hepatitis C patients, the viral agent is well known to replicate in the hepatocytes and extrahepatic cells. Previous studies have demonstrated a new form of hepatitis C called 'Occult HCV Infection' (OCI). It is defined as the presence of HCV RNA in the hepatocytes but undetectable HCV RNA in the serum or plasma. The exact natural history, epidemiology, pathogenesis and clinical importance of OCI are unknown. Several studies have been carried out worldwide, but none from Malaysia. This study investigated OCI among local patients undergoing routine hemodialysis at a referral hospital in Pahang, Malaysia. Materials and Methods: Blood was collected from both anti-HCV positive (n=10) and anti-HCV negative (n=18) patients. Inclusion criteria for the seronegative patients included elevated liver enzymes. Results: 10 chronic hepatitis C patients were recruited in this study. All had viral RNA detected in both serum and peripheral blood mononuclear cells (PBMC). Viral quasispecies was common in this group of patients. Meanwhile, out of 18 seronegative patients, 3 patients (16%) showed active viral replication in PBMC. Conclusion: This study proved the existence of OCI in local haemodialysis setting. Further investigation is needed to get the actual prevalence of OCI.
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Abdul Rahman, Siti Nurul Fazlin, Hairul Aini Hamzah, and Mohammed Imad Mustafa. "Existence of Occult Hepatitis C virus Infection in Local Haemodialysis Setting." IIUM Medical Journal Malaysia 17, no. 1 (December 14, 2018). http://dx.doi.org/10.31436/imjm.v17i1.848.

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Introduction: Among chronic hepatitis C patients, the viral agent is well known to replicate in the hepatocytes and extrahepatic cells. Previous studies have demonstrated a new form of hepatitis C called 'Occult HCV Infection' (OCI). It is defined as the presence of HCV RNA in the hepatocytes but undetectable HCV RNA in the serum or plasma. The exact natural history, epidemiology, pathogenesis and clinical importance of OCI are unknown. Several studies have been carried out worldwide, but none from Malaysia. This study investigated OCI among local patients undergoing routine hemodialysis at a referral hospital in Pahang, Malaysia. Materials and Methods: Blood was collected from both anti-HCV positive (n=10) and anti-HCV negative (n=18) patients. Inclusion criteria for the seronegative patients included elevated liver enzymes. Results: 10 chronic hepatitis C patients were recruited in this study. All had viral RNA detected in both serum and peripheral blood mononuclear cells (PBMC). Viral quasispecies was common in this group of patients. Meanwhile, out of 18 seronegative patients, 3 patients (16%) showed active viral replication in PBMC. Conclusion: This study proved the existence of OCI in local haemodialysis setting. Further investigation is needed to get the actual prevalence of OCI.
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SNF, Abdul Rahman, Hamzah HA, and Mustafa MIA. "Seronegative Occult Hepatitis C Virus Infection (OCI) in a Main Haemodialysis Centre In Pahang, Malaysia." IIUM Medical Journal Malaysia 18, no. 3 (November 3, 2020). http://dx.doi.org/10.31436/imjm.v18i3.188.

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Introduction: Occult HCV infection has a predilection for specific populations such as haemodialysis (HD) patients. The exact natural course, epidemiology, pathogenesis and clinical importance of OCI are unknown. We investigated the existence of OCI among local patients undergoing routine HD at a referral hospital in Pahang, Malaysia. Methods: Serum and peripheral blood mononuclear cells (PMBCs) were collected from peripheral venous blood samples of seropositive (anti-HCV positive) and seronegative (anti-HCV negative) HD patients as well as healthy individuals (negative control group). Inclusion criteria for the seronegative patients included elevated liver enzymes. Both conventional PCR and strand-specific PCR were used to detect the viral RNA and to indicate active viral replication in PBMCs respectively. Direct DNA sequencing was done to confirm the viral HCV RNA and their genotypes. Results: In the majority (90-100%) of seropositive chronic hepatitis C patients, viral RNA was detected in both serum and PMBCs . Meanwhile, out of 22 seronegative patients, 6 (27%) showed active viral replication in PBMCs but no detectable viral RNA presence in the serum. None of the negative control group had detectable viral RNA. All seronegative patients with OCI were infected with HCV genotype 3 and two of them (2/6) had a slight elevation of their liver enzymes. Conclusion: Seronegative OCI does exist among local hemodialysis patients, with normal or persistently abnormal liver enzyme values. Further investigation is needed to study the mode of viral transmission and clinical significance of OCI in HD setting.
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Wong, Wei‐Kei, Wah‐Kheong Chan, Shubash Shander Ganapathy, and Soo‐Kun Lim. "Metabolic dysfunction‐associated fatty liver disease (MAFLD) and advanced liver fibrosis among hemodialysis patients in a multiethnic urban population in Malaysia." Seminars in Dialysis, July 12, 2022. http://dx.doi.org/10.1111/sdi.13117.

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Viecelli, Andrea K., Armando Teixeira-Pinto, Andrea Valks, Richard Baer, Roy Cherian, Pietro E. Cippà, Jonathan C. Craig, et al. "Study protocol for Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID)." BMC Nephrology 23, no. 1 (November 19, 2022). http://dx.doi.org/10.1186/s12882-022-02987-1.

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Abstract Background A functioning vascular access (VA) is crucial to providing adequate hemodialysis (HD) and considered a critically important outcome by patients and healthcare professionals. A validated, patient-important outcome measure for VA function that can be easily measured in research and practice to harvest reliable and relevant evidence for informing patient-centered HD care is lacking. Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID) aims to assess the accuracy and feasibility of measuring a core outcome for VA function established by the international Standardized Outcomes in Nephrology (SONG) initiative. Methods VALID is a prospective, multi-center, multinational validation study that will assess the accuracy and feasibility of measuring VA function, defined as the need for interventions to enable and maintain the use of a VA for HD. The primary objective is to determine whether VA function can be measured accurately by clinical staff as part of routine clinical practice (Assessor 1) compared to the reference standard of documented VA procedures collected by a VA expert (Assessor 2) during a 6-month follow-up period. Secondary outcomes include feasibility and acceptability of measuring VA function and the time to, rate of, and type of VA interventions. An estimated 612 participants will be recruited from approximately 10 dialysis units of different size, type (home-, in-center and satellite), governance (private versus public), and location (rural versus urban) across Australia, Canada, Europe, and Malaysia. Validity will be measured by the sensitivity and specificity of the data acquisition process. The sensitivity corresponds to the proportion of correctly identified interventions by Assessor 1, among the interventions identified by Assessor 2 (reference standard). The feasibility of measuring VA function will be assessed by the average data collection time, data completeness, feasibility questionnaires and semi-structured interviews on key feasibility aspects with the assessors. Discussion Accuracy, acceptability, and feasibility of measuring VA function as part of routine clinical practice are required to facilitate global implementation of this core outcome across all HD trials. Global use of a standardized, patient-centered outcome measure for VA function in HD research will enhance the consistency and relevance of trial evidence to guide patient-centered care. Trial registration Clinicaltrials.gov: NCT03969225. Registered on 31st May 2019.
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Al-Shawkany, Eman Mohammad, Abdul-Al-Raoof Mohammad AlShawkany, Saleh S. Bahaj, Arwa Mohammed Othman, Hassan A. Al-Shamahy, and Azhar Azher Mohammed Al-Ankoshy. "PREVALENCE OF DIFFERENT HEPATITIS B VIRUS GENOTYPES AND RISK FACTORS ASSOCIATED AMONG SELECTED YEMENI PATIENTS WITH CHRONIC HEPATITIS B INFECTION." Universal Journal of Pharmaceutical Research, July 15, 2021. http://dx.doi.org/10.22270/ujpr.v6i3.603.

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Background and aims: Hepatitis B virus infection is a significant public health crisis global. Hepatitis B virus genotyping is an important tool in epidemiological studies to determine the category and extent of treatment and to predict the outcome of chronic infections, for instance hepatocellular carcinoma and cirrhosis. The study designed to determine the prevalence of hepatitis B virus genotypes among Yemeni patients with chronic hepatitis B (CHB) and to evaluate some of the associated risk factors. Methods: Fifty patients (38 males, 12 females) with chronic hepatitis B from Al-Thawra Modern General Hospital, Al-Kuwait University Hospital, and AL-Gomhoria Hospital were included. HBV DNA was first detected by conventional PCR then HBV genotypes were determined using nested and multiplex PCR. Results: Mixed HBV genotypes (A+B+C+D+E), (A+B+C+D+E+F), and (A+B+C+D) were found to be the most prevalent (60 %), it is followed by genotype D (16 %), genotype B (16%) and genotype A (8%), whereas C, E, and F genotype were not found individually among the study population. Blood transfusion was associated with mixed infection (χ2=13.06; p= 0.005). Conclusions: In assumption, this study demonstrates the general prevalence of hepatitis B virus genotypes among HBV-infected Yemeni hepatitis B patients who request medical consideration in a hospital. In mono-genotype HBV infection, genotype B and D were the most prevalent genotypes. In HBV mixed genotype infection, the A/B/C/D/E genotype was the most prevalent in the study area. In the future, based on genotype, clinical trials and treatment regimens must be individually assumed to efficiently manage chronic HBV infection. To this end, a prospective nationwide population study of HBV genotype spreading and clinical outcomes is suggested. Peer Review History: Received: 15 May 2021; Revised: 11 June; Accepted: 27 June, Available online: 15 July 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Salfarina Ramli, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. salfarina2892@uitm.edu.my Dr. Asia Selman Abdullah, University of Basrah, Iraq, asia_abdullah65@yahoo.com Similar Articles: EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN PREVALENCE AND GENOTYPING OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS AND EVALUATION OF HCV-CORE ANTIGEN TEST IN SCREENING PATIENTS FOR DIALYSIS IN SANA'A CITY, YEMEN PREVALENCE OF HBV AND HCV; AND THEIR ASSOCIATED RISK FACTORS AMONG PUBLIC HEALTH CENTER CLEANERS AT SELECTED PUBLIC HEALTH CENTERS IN SANA'A CITY-YEMEN
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Al-Shami, Huda Zaid, Zaid Ali Mohammed Al-Mutawakal, Abdulwahab Ismail Mohamed Al-Kholani, Muhamed Ahmed Al-Haimi, Ahmed Mohammed Al-Haddad, Redhwan A. Ahmed, Ali Abdullah Al-Somainy, and Hassan Abdulwahab Al-Shamahy. "PREVALENCE OF HEPATITIS A VIRUS, HEPATITIS B VIRUS, AND HEPATITIS C VIRUS, AMONG PATIENTS WITH HEPATIC JAUNDICE IN SANA’A CITY, YEMEN: A HOSPITAL BASED STUDY." Universal Journal of Pharmaceutical Research, January 15, 2022. http://dx.doi.org/10.22270/ujpr.v6i6.693.

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Background: Hepatic jaundice results from abnormal metabolism of bilirubin in the liver. The main hepatic jaundice causes are severe damage to hepatocytes due to autoimmune diseases, infectious diseases, drugs/ medication induced, or, less commonly, hereditary genetic diseases. Aim: The aim of this study is to determine the prevalence of hepatitis B Virus (HBV), hepatitis A virus (HAV), and hepatitis C virus (HCV), in patients with hepatic jaundice as causes of acute viral hepatitis (AVH) in Sana'a city, Yemen. Subjects and Methods: Data of patients with hepatic jaundice tested for hepatitis B surface antigen, total anti-HCV antibody, and anti-HAV immunoglobulin M (IgM) by enzyme-linked immunosorbent assay were collected from Class I Viral Diagnostic Laboratories in Sana'a for 3 years. Then the statistical analysis of the data was used where the descriptive analysis was calculated: frequency and percentage, as well as the association of infection with sex and age group by means of detection odds ratio, 95% CI and X2 more than 3.9 and P<0.05 were considered statistically significant. Results: The study included 644 males (43.8%) and 826 females (56.2%), while most patients were less than 21 years old. The rate of Hepatitis viruses positive was 27.6% positive. Hepatitis A virus infection was the most common virus diagnosed accounting for 259 cases (17.6% of the total), while HBV was less common with 104 (7.1%) and HCV only 42 cases (2.9%). The highest incidence of hepatitis B was in 11-20 years patients (18.2%), with an associated OR 9.3 (p < 0.0001). The highest incidence of hepatitis C was in 31-40 years patients (7.3%), with an associated OR 3.3 (p<0.0001). Conclusion: Alarmingly changing the epidemiology and dynamics of hepatitis A-C viruses in Yemen, a detailed study is required to understand the definite disease problem caused by these viruses. It is noticeable in this study the high prevalence of hepatitis A virus and hepatitis B virus in the Yemeni population with hepatic jaundice. Also, to our knowledge, this study is the first to report epidemiological transformation of hepatitis A virus in Sana'a, Yemen. Peer Review History: Received: 13 November 2021; Revised: 11 December; Accepted: 30 December, Available online: 15 January 2022 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Gulam Mohammed Husain,, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, gmhusain@gmail.com Dr. Salfarina Ramli, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. salfarina2892@uitm.edu.my Similar Articles: PREVALENCE OF DIFFERENT HEPATITIS B VIRUS GENOTYPES AND RISK FACTORS ASSOCIATED AMONG SELECTED YEMENI PATIENTS WITH CHRONIC HEPATITIS B INFECTION SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN
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Edrees, Wadhah Hassan, Bashir Ahmed Al-Ofairi, Lutf Mohammed Alrahabi, Ihab Muhammad Al-Munkari, Ahmed Saleh Alawi, Al-Hussein Taher Al-Mashdali, Ghassan Bakil Samin, Youssef Anwar Naseer, Zaher Abdullah Bamousa, and Wadee Abdullah Al-Shehari. "SEROPREVALENCE OF THE VIRAL MARKERS OF HEPATITIS B, HEPATITIS C, AND HIV AMONG MEDICAL WASTE HANDLERS IN SOME HOSPITALS IN SANA'A CITY- YEMEN." Universal Journal of Pharmaceutical Research, July 15, 2022. http://dx.doi.org/10.22270/ujpr.v7i3.774.

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Abstract:
Background and Objective: Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are highly contagious pathogens that threaten medical waste handlers who are highly exposed to these viruses due to the nature of their work. To date, little data is available on the prevalence of viral markers (HBV, HCV, and HIV) among medical waste handlers in Sana'a city, Yemen. Hence, this work was conducted to enhance knowledge of the prevalence of viral markers among medical waste handlers working in some hospitals in the capital, Sana'a. Methods: A cross-sectional prospective study was conducted on 120 randomly selected medical waste handlers from January to June 2022. A pretested and designed questionnaire was used to collect the required data. Total 5mL of venous blood was collected. Then blood was tested for hepatitis B surface antigen and anti-HCV, as well as HIV antibody, were detected using a qualitative by rapid test cassette and positive results were confirmed by ELIZA technique. Results: The overall positive rates for HBsAg, anti-HCV, and HIV were 9.17%, 5.0%, and 0.0%, respectively, based on the rapid test. No significant differences were detected between socio-demographic characteristics and hepatitis B and HCV infection. High rates of hepatitis B and C infection were found in the age group ≥41 years (9.17%) and 21-30 years (8.77%), respectively. These two viruses have also been detected among married people with a history of acute infection between 7-9 times. There was a significant correlation between HBsAg positivity and history of blood transfusion as well as between HBsAg and anti-HCV positivity and history of hepatitis B vaccination. ELISA confirmed that the rate of HBsAg was 4.17% and anti-HCV was 2.5%. Conclusion: Appropriate training, immunization against HBV, and regular motivation of medical waste handlers on the practices of universal standard precautions are recommended to reduce transmission of hepatitis B virus, hepatitis C virus, and HIV among medical waste handlers. Peer Review History: Received: 4 May 2022; Revised: 14 June; Accepted: 27 June, Available online: 15 July 2022 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Rusmir Baljic, Clinic for infectious diseases, Clinical center University of Sarajevo, Bosnia and Herzegovina. rusmir.baljic@gmail.com Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. Jucimary Vieira dos Santos, Hemonorte Dalton Barbosa Cunha, Brazil, jucimaryvieira@yahoo.com.br Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Similar Articles: PREVALENCE OF HEPATITIS A VIRUS, HEPATITIS B VIRUS, AND HEPATITIS C VIRUS, AMONG PATIENTS WITH HEPATIC JAUNDICE IN SANA’A CITY, YEMEN: A HOSPITAL BASED STUDY SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN
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