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Dissertations / Theses on the topic 'Hematopoietic stem and progenitor cell'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Liu, Yi. "LATEXIN’S ROLE IN REGULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/11.

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Previous studies in our lab identified a novel gene, latexin (Lxn), that regulates murine hematopoietic stem cells through balancing apoptosis, self-renewal and proliferation. In these dissertation studies, I performed a series of experiments to examine the function of Lxn using a Lxn conventional knockout mouse, and characterize Lxn’s role in the presence of hematopoietic stresses such as ionizing radiation, cytokines induced-mobilization, and hematopoietic malignancy. The first series of experiments was designed to determine the role of Lxn in hematopoiesis under homeostatic conditions. I fo

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2

Traveset, Martínez Laia 1992. "New insights into transcription that preserve hematopoietic stem cell homeostasis." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670105.

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Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding their numbers and increasing the output of blood cells. This dynamic and highly complex process needs to be fully regulated in order to maintain a balance between the differentiation of HSCs and the need to keep a constant pool of HSCs. However, the molecular machinery in charge of this tight regulation has yet to be fully characterized. HSCs represent a small proportion inside

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3

Kollek, Matthias [Verfasser], and Miriam [Akademischer Betreuer] Erlacher. "Improvement of hematopoietic stem cell transplantations by transient apoptosis inhibition in donor stem and progenitor cells." Freiburg : Universität, 2016. http://d-nb.info/1136263462/34.

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4

Tabayoyong, William Borj. "Engraftment of embryonic stem cell-derived hematopoietic progenitor cells is regulated by natural killer cells." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1089.

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Embryonic stem (ES) cells possess the remarkable ability to form cells and tissues from all three germ layers, a characteristic known as pluripotency. In particular, the generation of ES cell-derived hematopoietic cells could serve as an alternate source of hematopoietic stem cells for transplantation in place of bone marrow cells, which are limited by donor availability and high immunogenicity. The advantages of ES cell-derived hematopoietic cells over bone marrow cells include a greater proliferative capacity, which alleviates the problems of donor shortage, and low level expression of MHC a

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5

Cova, Giovanni. "The role of Helios in the hematopoietic stem and progenitor cell development." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ092.

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Les cellules souches et progénitrices hématopoïétiques (CSPH) produisent les cellules sanguines durant toute la vie. Elles sont divisées en cellules souches indifférenciées (CSH) et en cellules progénitrices multipotentes engagées (MPP). Les MPP sont hétérogènes et composées de cellules progénitrices multipotentes engagées vers les lignages érythro-mégacaryocytaires (MPP2), myéloïdes (MPP3) et lymphoïdes (MPP4). Malgré que ces populations cellulaires soient bien définies, les mécanismes moléculaires gouvernants leurs différenciations restent en grande partie encore inconnus. Nous avons montré

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6

Schütte, Judith. "Analysis of regulatory networks in blood stem/progenitor cells." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648631.

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7

Guthrie, Steven Mitchell. "Hemangioblasts from hematopoietic stem cells to endothelial progenitor cells and their effector molecules /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010068.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 95 pages. Includes Vita. Includes bibliographical references.

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8

Chen, Inn-Inn. "The role of ephrinB2 in hematopoietic stem/progenitor cell differentiation from an arterial hemogenic endothelium." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3a561742-155f-447e-beb6-42ede41d9bb5.

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During development, hematopoiesis develops in temporally distinct waves in the yolk sac (YS) and embryo proper, culminating in the emergence of definitive hematopoietic stem cells (HSCs) from the hemogenic endothelium (HE) of the dorsal aorta. The close association of this aortic endothelium with definitive hematopoiesis suggests a functional relationship between arteriogenesis and blood development, but this association is not fully understood. To gain insight into this relationship, we have chosen to study the role of the “arterial” marker, EphrinB2 (EfnB2) in hematopoietic specification. Ef

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9

Eliasson, Pernilla. "Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells." Doctoral thesis, Linköpings universitet, Experimentell hematologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52932.

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The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. The HSCs are located in specialized niches in the bone marrow thought to be low in oxygen, which is suggested to be involved in the regulation of HSC maintenance, proliferation, and migration. However, the importance of hypoxia in the stem cell niche and the molecular mechanisms involved remain fairly undefined. Another important regulator of hu

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10

McBrien, Marie. "The effect of Poly I:C induced inflammation on hematopoietic stem and progenitor cell behaviour in the zebrafish hematopoietic transplant model." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/55871.

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Hematopoietic stem cells are a small but significant population of cells fundamental for generating and maintaining the hematopoietic system. These cells are used in the treatment of cancer and auto-immune patients. Studies in mammals suggest that inflammation and infection can modulate the biology of these cells, affecting their location, self-renewal capacity and directing differentiation. The aim of this work was to study the effect of repeated stimulation on the hematopoietic stem and progenitor (HSPCs) population in zebrafish (Danio rerio) to benefit from the live imaging potential of thi

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11

Dahl, Lina. "Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development." Doctoral thesis, Umeå universitet, Umeå centrum för molekylär medicin (UCMM), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35933.

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When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. Many processes regulating organ development are based on epithelial-mesenchymal interactions and a strict control of organ specific stem/progenitor cells. Elucidation of the molecular basis of these processes is therefore vital in order to develop novel therapies in regenerative medicine. The LIM homebox gene Lhx2 is

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12

QUARANTA, PAMELA. "Unveiling the biological role of human circulating Hematopoietic Stem and Progenitor cells." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/128257.

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Although mostly resident in the bone marrow (BM), few circulating HSPC (cHSPC) regularly traffic in the peripheral blood (PB) of un-mobilized subjects. Mainly descriptive studies have been published so far about this rare population in humans, and a complete evaluation of their composition, functional features and hierarchical relationship with respect to BM HSPC is still missing. In the present study, we phenotypically characterized cHSPC composition during aging, by applying multi-parametric flow cytometry on 114 PB and, as control, 48 BM samples of healthy donors (HD) of diverse age. These

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13

Bergman, Märta. "Evaluation of an automated method for measuring hematopoietic progenitor cells to determine the start of stem cell apheresis." Thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406566.

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Stem cell transplantation is a known treatment for various cancers. Currently most cells transplanted are collected via apheresis. An injection of growth factor is given to the patient to start the proliferation and mobilization of stem cells. Apheresis can be initiated when the patient has a stem cell count of 15 to 20 stem cells/µL of peripheral blood. The standard method with which stem cells are analysed is immune flow cytometry where CD34+ and CD45+ are identified with targeted fluorescent antibodies. This analysis takes more than 45 minutes to perform. Sysmex XN-9000 analyses samples

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14

Ewels, Philip Andrew. "Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245861.

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The eukaryotic cell nucleus is a highly organised organelle, with distinct specialised sub- compartments responsible for specific nuclear functions. Within the context of this functional framework, the genome is organised, allowing contact between specific genomic regions and sub-compartments. Previous work has shown that genes in both cis and trans can make specific contacts with each other. I hypothesise that such a preferred juxtaposition may impact the propensity for specific cancerinitiating chromosomal translocations to occur. In this thesis, I describe how I have extended and developed

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15

Löffler, Dirk [Verfasser], and Heinrich [Akademischer Betreuer] Leonhardt. "Asymmetric Segregation of lysosomes during hematopoietic stem and progenitor cell divisions / Dirk Löffler ; Betreuer: Heinrich Leonhardt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1114661236/34.

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16

Elhossaini, Hawraa. "Proliferation and Primitivity of Hematopoietic Progenitor Cells in Hypoxic Hypercapnic Conditions." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/30010.

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This thesis aims to improve the in vitro cultivation of hematopoietic stem cells (HSCs) by exploring the effects of various biophysical and biochemical factors. The study uses KG-1a cells as a model for HSCs and evaluates the impact of different O2/CO2 conditions on apoptosis, proliferation, and primitivity. Additionally, the effect of differently-treated cuttlefish bone (CB) on mouse bone marrow hematopoietic cells is examined. The results show that combining hypoxia and hypercapnia is more effective in maintaining CD34+ cell count, survival, and primitivity compared to other gas combinations

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17

Benson, Eric Ashley. "Loss of SIMPL increases TNFalpha sensitivity during hematopoiesis." Connect to resource online, 2008. http://hdl.handle.net/1805/1851.

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Thesis (Ph. D.)--Indiana University, 2008.<br>Title from screen (viewed June 24, 2009). Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Maureen Harrington. Includes vita. Non-Latin script record. Includes bibliographical references (leaves 126-132).

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18

Diedrich, Beatrice. "Storage and transfusion of platelets in vitro and in vivo studies in healthy volunteers and in allogeneic hematopoetic progenitor cell transplant recipients /." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-280-6/.

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19

Patrizia, Marzorati. "Characterisation of Hematopoietic Stem/Progenitor cells and their mobilization in uPAR KO mice." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524734.

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20

Lin, Shan. "Modeling and Analysis of Acute Leukemia using Human Hematopoietic Stem and Progenitor Cells." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1481032144780412.

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21

Cochonneau, Stéphanie. "Modulating hematopoietic progenitor cell engraftment and T cell differentiation : role of conditioning and route of administration." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20226.

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Les déficits lymphocytaires T peuvent être corrigés par l'administration en intraveineuse (IV) de cellules souches hématopoiétiques (CSH) provenant d'un donneur. Dans un modèle d'immunodéficience lié à l'absence de la protéine kinase ZAP-70, notre équipe avait précédemment montré que l'injection intrathymique (IT) de CSH histocompatibles conduit à une reconstitution du compartiment T plus robuste et plus rapide que dans le cas où les CSH sont administrées par voie IV. Au cours de ma thèse, je me suis intéressée à l'approche IT dans un contexte non-histocompatible, où j'ai montré que l'injectio

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22

Xin, Xing. "Effects of polychlorinated biphenyls (PCBs) on telomere maintenance in hematopoietic stem cells and progenitor cells." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2026.

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Polychlorinated biphenyls (PCBs) are synthetic persistent organic compounds that are known to be carcinogenic to humans. Changes in telomerase activity and telomere length are hallmarks of aging and carcinogenesis. Retention of telomerase activity and long telomeres are key characteristics of stem cells and progenitor cells. I hypothesize that PCBs modulate telomerase activity and telomeres of hematopoietic stem cells and progenitor cells via interference of gene regulation and potentially disrupt c

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23

Edling, Charlotte. "Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells." Doctoral thesis, Umeå : Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-888.

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24

Yates, Jeffrey Lynn. "THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM/PROGENITOR CELLS TO THE CYTOSTATIC AGENT HYDROXYUREA." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/420.

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Cellular proliferation is a key characteristic of hematopoietic stem and progenitor cells (HSC/HPCs) that allows for the production of all blood cell lineages during an individuals lifetime. While this feature of stem cells is strictly regulated during steadystate and stress hematopoiesis, it also contributes to the development of myeloproliferative disorders, such as chronic myelogenous leukemia, essential thrombocythemia, and polycythemia vera. It should come as no surprise then, that common treatments for these diseases often target the proliferative nature of the dysfunctional HSC/HPCs. Th

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25

Thieme, Sebastian, Sabine Stopp, Martin Bornhäuser, et al. "Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-178636.

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The melanoma cell adhesion molecule defines mesenchymal stromal cells in the human bone marrow that regenerate bone and establish a hematopoietic microenvironment in vivo. The role of the melanoma cell adhesion molecule in primary human mesenchymal stromal cells and the maintenance of hematopoietic stem and progenitor cells during ex vivo culture has not yet been demonstrated. We applied RNA interference or ectopic overexpression of the melanoma cell adhesion molecule in human mesenchymal stromal cells to evaluate the effect of the melanoma cell adhesion molecule on their proliferation and dif

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26

Thieme, Sebastian, Sabine Stopp, Martin Bornhäuser, et al. "Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells." Ferrata Storti Foundation, 2013. https://tud.qucosa.de/id/qucosa%3A28908.

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The melanoma cell adhesion molecule defines mesenchymal stromal cells in the human bone marrow that regenerate bone and establish a hematopoietic microenvironment in vivo. The role of the melanoma cell adhesion molecule in primary human mesenchymal stromal cells and the maintenance of hematopoietic stem and progenitor cells during ex vivo culture has not yet been demonstrated. We applied RNA interference or ectopic overexpression of the melanoma cell adhesion molecule in human mesenchymal stromal cells to evaluate the effect of the melanoma cell adhesion molecule on their proliferation and dif

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27

Ma, Kuiying. "Regulation of early human T cell development Generation of adult human T-cell progenitors for immunotherapeutic applications TNFα enhances in vitro generation of T-cell precursors from human hematopoietic stem and progenitor cells". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB040.

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La première étape du développement lymphocytaire T se caractérise par la migration de progéniteurs hématopoïétiques dans le thymus et l'initiation du programme de différenciation T. La régulation du développement des lymphocytes T est étroitement associée au micro-environnement du thymus. Cependant, en raison de modèles d'étude limités, les mécanismes régulant le développement des lymphocytes T humains sont encore peu compris. Nous avons donc développé un système de culture in vitro sans stroma qui soutient le développement précoce des cellules T humaines à partir de cellules souches / progéni

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28

Saiki, Norikazu. "Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors." Kyoto University, 2018. http://hdl.handle.net/2433/232478.

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29

Hermida, Felipe Pessoa de Melo. "Células progenitoras CD34+ durante a ampliação esplênica na malária experimental de roedores." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-18102007-153435/.

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A malária é uma infecção causada por plasmódios, cujo controle depende do baço, o responsável pelo clareamento dos eritrócitos parasitos. O aumento da parasitemia induz uma ampliação do baço para resolver a infecção, onde participam células precursoras que apresentam CCD34+ na sua superfície. Estudamos a distribuição e a quantidade de células CD34+ em baços de roedores durante malárias de roedores, para compreender sua participação na ampliação do baço e no controle da infecção. Camundongos C57Bl/6j infectados com as cepas AJ e CR de Plasmodium chabaudi, e com a cepa ANKA de Plasmodium berghei

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30

Pirman, Megan. "An In Vitro Study on the Role of Endothelial Cell Connexin43 Gap Junctions in the Regulation of Hematopoietic Stem and Progenitor Cells Traffic." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267459743.

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31

Joshi, Shrinidh Ashokkumar. "Hypoxic Regulation of Angiotensin-Converting Enzyme 2 and Mas Receptor in Hematopoietic Stem/Progenitor Cells: A Translational Study." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/28961.

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Vascular disease is the leading cause of mortality and morbidity in the western world, and account for the 1 of every 3 death?s in the US, but a cure for vascular disease is yet to be realized. Hematopoietic stem progenitor cells (HSPCs) are mobilized from bone marrow and have the innate propensity to accelerate vascular repair by reendothelialization and revascularization of ischemic areas. The vasoreparative ability of HSPCs is largely due to their capacity to home to the areas of hypoxia and their sensitivity to hypoxia plays a critical role in the vasoreparative functions of these cells. T

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32

Hovey, Owen. "Characterization of Proteins Released by Osteoblasts That Promote Expansion of Hematopoietic Progenitors." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38012.

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Umbilical cord blood (UCB) is a source of hematopoietic stem and progenitor cells (HSPC) used for allogeneic transplantation. Ex vivo expansion of HSPC can improve the slow platelet and neutrophil engraftment associated with UCB transplants. HSPCs reside in niches, some of which are near the endosteal bone surface, where they can associate with immature osteoblasts. Interestingly, osteoblasts can enhance the growth of HSPC in culture and their platelet engraftment activity. Using a proteomics approach, I identified 47 differentially expressed proteins between mesenchymal stem cells and immatur

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33

Bauer, Nicola, Ana-Violeta Fonseca, Mareike Florek, et al. "New Insights into the Cell Biology of Hematopoietic Progenitors by Studying Prominin-1 (CD133)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136136.

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Prominin-1 (alias CD133) has received considerable interest because of its expression by several stem and progenitor cells originating from various sources, including the neural and hematopoietic systems. As a cell surface marker, prominin-1 is now used for somatic stem cell isolation. Its expression in cancer stem cells has broadened its clinical value, as it might be useful to outline new prospects for more effective cancer therapies by targeting tumor-initiating cells. Cell biological studies of this molecule have demonstrated that it is specifically concentrated in various membrane structu

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34

Elattar, Afaf Ibrahim Mohammed Behery. "The role of hematopoietic stem/progenitor cells (HSPCs) in the development of inflammation in non-alcoholic steatohepatitis (NASH)." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22138.

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Non-alcoholic fatty liver disease (NAFLD) is a common chronic hepatic disease that affects about a quarter of the global population. Between 5 and 10% of patients with NAFLD develop non-alcoholic steatohepatitis (NASH), the inflammatory and progressive form that is characterized by liver cell injury/death and inflammation. NASH patients are at higher risks for developing liver fibrosis, cirrhosis, and hepatocellular carcinoma. Indeed NAFLD/NASH is the third leading indication for liver transplantation. NAFLD is also a systemic disease which is able to disrupt metabolic homeostasis and is an in

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35

Hoppe, Philipp [Verfasser], and Thomas [Akademischer Betreuer] Cremer. "Continuous quantification of transcription factor dynamics in individual hematopoietic stem and progenitor cells / Philipp Hoppe. Betreuer: Thomas Cremer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1077439377/34.

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Hoppe, Philipp Verfasser], and Thomas [Akademischer Betreuer] [Cremer. "Continuous quantification of transcription factor dynamics in individual hematopoietic stem and progenitor cells / Philipp Hoppe. Betreuer: Thomas Cremer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-187381.

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An, Ningfei, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft, and Yubin Kang. "Pim1 kinase regulates c-Kit gene translation." BIOMED CENTRAL LTD, 2016. http://hdl.handle.net/10150/622957.

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Background: Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. Methods and results: We demonstrated that loss of Pim1 led to specific down-regulation of c-Kit expression in HSPCs of Pim1(-/-)mice and Pim1(-/-)2(-/-)3(-/-) triple knockout (TKO) mice, and resulted in attenu

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38

Costa, Everton de Brito Oliveira. "Caracterização das Células-Tronco/Progenitoras Hematopoéticas obtidas de Células-Tronco Embrionárias Humanas In Vitro em Sistema de Co-Cultivo com Fibroblastos de Embriões Murinos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-131047/.

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A hematopoese tem sido bem descrita em modelos murinos nas últimas décadas, contudo, trabalhos demonstrando os mecanismos da hematopoese em humanos ainda são escassos. A derivação da primeira linhagem de células-tronco embrionárias humanas (CTEhs) em 1998, gerou novas perspectivas tanto para o estudo da hematopoese na tentativa de mimetizar o que ocorre naturalmente durante o desenvolvimento embrionário, quanto para a aplicação clínica das células hematopoéticas obtidas a partir da diferenciação dessas células. Contudo, apesar de inúmeros trabalhos terem demonstradoa obtenção de células hemato

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39

McKinnon, Timothy [Verfasser]. "Hematopoietic Stem / Progenitor Cells and placental vascular development : in vitro study on the role of oxygen and stromal-derived factor-1alpha in the establishment of a stem cell niche / Timothy McKinnon." Gießen : Universitätsbibliothek, 2007. http://d-nb.info/1058561669/34.

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40

Esplin, Brandt L. "Replenishment of innate immune system in health and disease." Oklahoma City : [s.n.], 2009.

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41

Bauer, Nicola, Ana-Violeta Fonseca, Mareike Florek, et al. "New Insights into the Cell Biology of Hematopoietic Progenitors by Studying Prominin-1 (CD133)." Karger, 2008. https://tud.qucosa.de/id/qucosa%3A27699.

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Prominin-1 (alias CD133) has received considerable interest because of its expression by several stem and progenitor cells originating from various sources, including the neural and hematopoietic systems. As a cell surface marker, prominin-1 is now used for somatic stem cell isolation. Its expression in cancer stem cells has broadened its clinical value, as it might be useful to outline new prospects for more effective cancer therapies by targeting tumor-initiating cells. Cell biological studies of this molecule have demonstrated that it is specifically concentrated in various membrane structu

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42

Zeng, Hui. "Requirement of the transcription factor and onco-protein Gfil for the development and function of hematopoietic stem cells and progenitor cells." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972510176.

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43

Buchanan, Sandhya S. "Preservation of two therapeutic biopharmaceuticals using sugars and polymers : hematopoietic stem and progenitor cells and a live attenuated viral vaccine /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado, 2006.<br>Typescript. Includes bibliographical references (leaves 191-216). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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44

Alsheikh, Manal. "Impact of the Maturation Status of Osteoblasts on Their Hematopoietic Regulatory Activity." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35899.

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Osteoblasts (OST) provide strong intrinsic growth modulatory activities on hematopoietic stem and progenitor cells via different mechanisms that include secretion of growth factors, and cellular interaction. Previously we showed that medium conditioned by mesenchymal stromal cell (MSC)-derived osteoblasts (M-OST) improve the expansion of cord blood (CB) CD34+ cells. I hypothesize that the hematopoietic supporting activity of M-OST would vary as a function of their maturation. This was tested by producing osteoblast conditioned media (OCM) from M-OST at distinct stages of maturation, and testin

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Hamad, Mouna. "Toward an Understanding of How Hypercapnia Affects Apoptosis in Human Promyeloblasts in 3D Suspension Culture Systems." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/16960.

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Stem cells have more recently attracted interest in scientific research and their use is increasingly developing in many therapeutic applications. A great deal of cell-based work is conducted at 5% CO2 concentration and is predominantly cultured on two-dimensional surfaces. These methods are straightforward and of low economic costs but do not necessarily replicate the microenvironment; also, evidence to provide justification for selecting this specific concentration of CO2 in hematopoietic progenitor cell (KG-1a) proliferation studies is lacking. Our work herein pursues to prove the following

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Chisi, John Eugenes. "The regulatory role of AcSDKP and angiotensin 1-converting enzyme (ACE) inhibitors on haematopoietic stem and progenitor cell proliferation." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14971.

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Negative regulatory factors inhibit the proliferation of haematopoietic stem cells thus protecting them from differentiation pressures. One of the negative regulators of stem cell proliferation is the tetrapeptide Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP). This peptide is endogenously produced in vivo and long term bone marrow cultures and is degraded by angiotensin 1-converting enzyme (ACE) both in vivo and in vitro. The aim of these investigations was to study the role of ACE on haematopoietic stem and progenitor cell proliferation. Since the N-domain ACE active has been implicated in AcS

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Bissels, Ute [Verfasser]. "Combined analysis of microRNA and mRNA signatures in human hematopoietic stem and progenitor cells using a novel microarray quantification system / Ute Bissels." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1016243669/34.

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Almoflehi, Sakhar. "Cord Blood CD34+ Expansion Using Vitamin-C: An Epigenetic Regulator." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41413.

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Vitamin-C (Vit-C) has been shown to modulate hematopoietic stem cells and leukemia stem cell frequency in-vivo. Herein, Vit-C analogue, L-ascorbic acid 2-phosphate (AA2P), was investigated as a new potential HSC expansion agonist. Cord blood CD34+ cells were expanded in cultures with or without AA2P. AA2P induced a 2-fold increase in the expansion of stem and progenitor subsets including lymphoid-primed multi-potential progenitors (p<0.05, n=3) and functional colony forming progenitors. The functional properties of AA2P grafts was evaluated with a xenotransplant model. Superior platelet levels

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Petiti, L. "NEXT-GENERATION SEQUENCING APPROACH FOR TRANSCRIPTOME AND EPIGENOME DEFINITION OF HUMAN HEMATOPOIETIC STEM/PROGENITOR CELLS AND THEIR EARLY ERYTHROID AND MYELOID COMMITTED PROGENY." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/286531.

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Somatic stem cells are the basic tools of regenerative medicine and gene therapy, providing unique opportunities for the therapy of genetic and acquired disorders. The molecular mechanisms underlying fundamental characteristics of human somatic stem cells, such as self-renewal, commitment and differentiation, are still poorly understood. A better knowledge of these mechanisms is crucial to the understanding of stem cell biology and to the development of stem cell-based therapies. High-throughput approaches, such as next-generation sequencing technologies (NGS) became fundamental to study the t

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Pessolato, Alícia Greyce Turatti. "Caracterização das células-tronco do saco vitelino e análise ultraestrutural da membrana vitelina de embriões ovinos (Ovis aries)." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-07082012-183204/.

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O saco vitelino é o único anexo embrionário presente em todas as espécies dos embriões vertebrados, répteis, aves e mamíferos. Em mamíferos domésticos o saco vitelino é inicialmente grande, pois nestas espécies ele é transitório. Após a implantação, surge no mesênquima lateral à notocorda agrupamentos de células, denominados ilhotas sanguíneas, que representam os progenitores dos sistemas vascular e hematopoético: os hemangioblastos. Os hemangioblastos centrais das ilhas sanguíneas formam as primeiras células-tronco hematopoéticas, enquanto os hemangioblastos periféricos se diferenciam em angi

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