Journal articles on the topic 'Helicobacter pylori infections'
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Suwarni, Sri, Cilmiaty Risya, Dono Indarto, and Suradi Pulmonology. "Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population." Bangladesh Journal of Medical Science 16, no. 4 (August 19, 2017): 515–20. http://dx.doi.org/10.3329/bjms.v16i4.33604.
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Background: Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal.Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori.Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R2 = 0,676. P < 0.001 ).Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.515-520
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S, Bhattacharyya. "Helicobacter pylori infections." Journal of Clinical Case Reports & Studies 5, no. 3 (May 30, 2024): 01–02. http://dx.doi.org/10.31579/2690-8808/193.
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Helicobacter pylori is a Gram-negative intracellular bacterium. It is implicated in many infections like peptic ulcer disease and can also cause gastric carcinoma. Diagnosis relies on various methods. Treatment can be done by various pharmacological methods.
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Haesebrouck, Freddy, Frank Pasmans, Bram Flahou, Koen Chiers, Margo Baele, Tom Meyns, Annemie Decostere, and Richard Ducatelle. "Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health." Clinical Microbiology Reviews 22, no. 2 (April 2009): 202–23. http://dx.doi.org/10.1128/cmr.00041-08.
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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.
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Nguyen, Julie, Kallirroi Kotilea, Patrick Bontems, and Veronique Yvette Miendje Deyi. "Helicobacter pylori Infections in Children." Antibiotics 12, no. 9 (September 12, 2023): 1440. http://dx.doi.org/10.3390/antibiotics12091440.
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In the context of epidemiology, host response, disease presentation, diagnosis, and treatment management, the manifestation of Helicobacter pylori (H. pylori) infection diverges between children and adults. H. pylori infection stands out as one of the most prevalent bacterial infections globally, and its prevalence in both children and adults is decreasing in many developing countries but some still struggle with a high prevalence of pediatric H. pylori infection and its consequences. The majority of infected children are asymptomatic and pediatric studies do not support the involvement of H. pylori in functional disorders such as recurrent abdominal pain. The pathophysiology of H. pylori infection relies on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. This interaction gives rise to diverse gastritis phenotypes, which subsequently influence the potential development of various gastroduodenal pathologies. In clinical settings, the diagnosis of this infection in childhood requires an upper gastrointestinal endoscopic exam with mucosal biopsy samples for histology and culture, or Polymerase Chain Reaction (PCR) at the very least. When warranted, eradication treatment should be given when good compliance is expected, and there should be systematic use of a treatment adapted to the antimicrobial susceptibility profile. To combat the burgeoning threat of multidrug resistance, vigilant surveillance of resistance patterns and strategic antibiotic management are paramount.
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Terry, Karianne, Susan M. Williams, Lynn Connolly, and Karen M. Ottemann. "Chemotaxis Plays Multiple Roles during Helicobacter pylori Animal Infection." Infection and Immunity 73, no. 2 (February 2005): 803–11. http://dx.doi.org/10.1128/iai.73.2.803-811.2005.
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ABSTRACT Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as specific gastric cancers. H. pylori infects approximately 50% of the world's population, and infections can persist throughout the lifetime of the host. Motility and chemotaxis have been shown to be important in the infection process of H. pylori. We sought to address the specific roles of chemotaxis in infection of a mouse model system. We found that mutants lacking cheW, cheA, or cheY are all nonchemotactic and infect FVB/N mice with an attenuated phenotype after 2 weeks of infection. If infections proceeded for 6 months, however, this attenuation disappeared. Histological and culture analysis revealed that nonchemotactic mutants were found only in the corpus of the stomach, while the wild type occupied both the corpus and the antrum. Further analysis showed that nonchemotactic H. pylori isolates had an increased 50% infectious dose and were greatly outcompeted when coinfected with the wild type. If nonchemotactic mutants were allowed to establish an infection, subsequent infection with the wild type partially displaced the nonchemotactic mutants, indicating a role for chemotaxis in maintenance of infection. The data presented here support four roles for chemotaxis in H. pylori mouse infections: (i) establishing infection, (ii) achieving high-level infection, (iii) maintaining an infection when there are competing H. pylori present, and (iv) colonizing all regions of the stomach.
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Rusalenko, M. G., M. Wisham, T. V. Konovalova, L. V. Lischenko, I. G. Savasteeva, and N. I. Shevchenko. "Significance of pathogen identification for urinary tract infection and <i>Helicobacter pylori</i> infection in type 1 and type 2 diabetes mellitus patients." Health and Ecology Issues 20, no. 2 (July 10, 2023): 35–41. http://dx.doi.org/10.51523/2708-6011.2023-20-2-05.
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Objective. The aim of this study was to understand the significance of pathogen identification for Urinary tract infection and Helicobacter pylori infection in Diabetes Mellitus Type 1 and Diabetes Mellitus Type 2 patients.Materials and methods. The study was conducted among 1749 patients with Type 1 and Type 2 Diabetes Mellitus. Using microbiological techniques, the frequency of urinary tract infection was identified and the aetiology and sensitivity of microorganisms to antibacterial drugs were assessed. Data collected on Helicobacter pylori infection were verified through PCR tests on biopsies collected from the gastric mucosa.Results. The study showed that urinary tract infection has a high incidence rate with 58.3% of cases from Type 1 diabetes mellitus, and in 47.2% of cases from Type 2 diabetes. Pathogens such as Escherichia coli, Staphylococcus saprophyticus, Enterococcus faecalis and Klebsiella pneumoniae were the main causative agents of urinary tract infections. Helicobacter pylori infection was common in DM and more in cases of Type 2 Diabetes Mellitus at 27.1%, compared to cases in Type 1 Diabetes Mellitus at 22.8%. Also 5.9 % cases of Type 2 Diabetes Mellitus had combined Helicobacter pylori and urinary tract infections.Conclusion. The study showed the significance in identification of urinary tract infections and Helicobacter pylori infections in patients with Type 1 and Type 2 Diabetes Mellitus, and especially significant for Type 2 Diabetes Mellitus patients.
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Bertholom, Chantal. "Infections à Helicobacter pylori." Option/Bio 26, no. 521 (February 2015): 13–15. http://dx.doi.org/10.1016/s0992-5945(15)30025-8.
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Pete, D., AI Phipps, NR Salama, JW Lampe, and MC Wu. "Assessing Helicobacter Pylori Infections Among Adults From the Navajo Nation." Cancer Epidemiology, Biomarkers & Prevention 32, no. 6 (June 1, 2023): 858. http://dx.doi.org/10.1158/1055-9965.epi-23-0359.
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A substantial burden of stomach cancer continues to be observed in American Indians in the United States (US). The Navajo Nation, the largest American Indian tribe in the Southwestern US, is experiencing a higher incidence of stomach cancer compared to the general population in the region, possibly due to the high prevalence of Helicobacter pylori (H. pylori) infection, an infectious pathogen that colonizes the stomach and is a major risk factor for stomach cancer. To assess the prevalence, virulence, and risk factors for H. pylori infection in Navajo adults, we initiated a cross-sectional study in two geographic areas of the Navajo Nation. Study recruitment occurred from January to October 2021 during the COVID-19 pandemic. Participants were recruited using online and offline platforms, including social media, a study website, newspaper advertisements, flyers, word of mouth, and community outreach. Demographic, health, behavioral, environmental, and diet factors were assessed from health and food frequency questionnaires. H. pylori infection and cagA virulence were detected from stool samples by droplet digital PCR. Of 99 participants recruited, 56.6% (95% CI: 46.2–66.5) of participants were infected with H. pylori and, among H. pylori-infected participants, 78.6% (95% CI: 65.6–88.4) were infected with a cagA-positive H. pylori strain. Having a history of H. pylori infection was inversely associated with H. pylori infection (OR = 0.05, 95% CI: 0.01–0.34, P = 0.005), and using Navajo herbal medicine once a month was positively associated with H. pylori infection (OR = 7.28, 95% CI: 1.40–61.12, P = 0.03). No significant associations were observed with other risk factors (e.g., older age, males, lower education levels, smoking, alcohol use, and high sodium intake). The prevalence of H. pylori infection was two times higher in adults in the Navajo ABID study compared to the US population (27% seroprevalence), and the prevalence of the cagA gene in H. pylori-infected participants was four times higher than the US population cagA gene prevalence in White people (19% seroprevalence). These findings provide a greater understanding of the burden of H. pylori and cagA-positive infections and can inform prevention strategies to reduce H. pylori infections in the Navajo Nat.
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Lauritano, Moreo, Carinci, Lucchese, Stasio, Vella, and Petruzzi. "Helicobacter Pylory and Oral Diseases." Proceedings 35, no. 1 (December 10, 2019): 16. http://dx.doi.org/10.3390/proceedings2019035016.
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Helicobacter pylori (H. pylori) gastric infection is considered one of the most common human infections. It occurs in half of the world’s population is the most common cause of adenocarcinoma of the distal stomach [1]. [...]
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Paradowski, Leszek. "Helicobacter pylori – a still ongoing problem." Medycyna Faktów 13, no. 4 (December 31, 2020): 491–95. http://dx.doi.org/10.24292/01.mf.0420.17.
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The diagnosis and treatment of Helicobacter pylori infection are up-to-date, which is due to the frequency of human infections and the consequences of the chronic once, in most cases Helicobacter pylori infection is asymptomatic. If there are symptoms, the most common are dyspeptic complaints. In some patients Helicobacter pylori causes severe disease, mainly in stomach. This pathogen has been recognized as the main cause of the peptic ulcer, gastric cancer and MALT lymphoma. It is also known to play an important role in some other disease such essential thrombocytopenia, some types of deficiency anemia. This article discusses the current on the epidemiology of Helicobacter pylori infection, its consequences, diagnosis, treatment and the prevention of infection, information on changes in flora of digestive tract that can occur during the eradication of this bacterium, is also presented.
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Khazaei, Zaher, Yousef Moradi, Hossein Ali Adineh, F. Rezaei, Malihe Sohrabivafa, Isan Darvishi, Seyedeh Leila Dehghani, and Elham Goodarzi. "Cancers Attributable to Infectious Agents: an Ecological Study in Asia." Asian Pacific Journal of Environment and Cancer 1, no. 1 (November 26, 2018): 35–40. http://dx.doi.org/10.31557/apjec.2018.1.1.35-40.
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Infections are a major contributor to cancer, especially in developing countries. Infections through the virus, bacteria and parasites are the most and most preventable causes of cancer in the world. The aim of the current study was to investigate the epidemiology of cancer-related infections in Asia. We considered 4 infectious agents classified as carcinogenic to human beings by the International Agency for Research on Cancer. We calculated the number of new cancer cases in 2012 attributable to infections by country, by combining cancer incidence estimates (from GLOBOCAN 2012) with the estimates of attributable fraction (AF) for the infectious agents. AF estimates were calculated from the prevalence of infection in cancer cases for the infection (for some sites). According to data registered in 2012, about 14 million new cases of cancer were detected worldwide of which 2. 2 million people (15.4%) diagnosed with cancer due to infection. The highest incidence of infectious cancers related to the African continent with a prevalence of 27.6% followed by Asian continents (21.4%), America (7.9%), Europe (7.3%) and Oceania (4.8%), respectively. In the Asian continent, of all cancers associated with infection in males, 48.1% were related to Helicobacter pylori infection, 33.2% of hepatitis B virus, 8% of hepatitis C and 3.3% of HPV and in women 47.4% HPV, 28.7% Helicobacter pylori, 15.3% Hepatitis B and 4.5% Hepatitis C, respectively. India (230,000 cases) and Japan (140,000 cases) were the most affected, while Bahrain (86 cases) and Brunei (88 cases) had the least cases of infection-related cancer. in Asia, the most common cancer-related infection in males and females were reported for Helicobacter pylori and HPV, respectively. Therefore, with preventive interventions aimed at reducing these infections, the burden of cancers can be reduced.
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Kuntoji, Shrikanth B., Ankita A. Naik, and Suhas D. S. "A prospective study of proportion of Helicobacter pylori infection in patients presenting with dyspeptic symptoms in S. Nijalingappa Medical College and H.S.K. Hospital, Bagalkot." International Surgery Journal 7, no. 8 (July 23, 2020): 2685. http://dx.doi.org/10.18203/2349-2902.isj20203255.
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Background: More than half of the world’s population is infected with Helicobacter pylori, the primary cause of chronic gastritis. Chronic gastritis is associated with peptic ulcer and in advanced stages with an increased risk of developing gastric adenocarcinoma. The aim of the study was to determine the prevalence of Helicobacter pylori infection in dyspeptic patients and its relationship with gastroduodenal pathologies using gastric biopsy histology.Methods: A cross sectional prospective study was conducted from 1st January 2018 to 30th June 2019. It included out-patients and in-patients, presenting with dyspeptic symptoms and undergoing upper GI Endoscopy, at S. Nijalingappa Medical College and HSK hospital, Bagalkot, Karnataka, India. Endoscopic impressions were noted. In case of any abnormal findings on upper gastrointestinal endoscopy, endoscopic biopsy was obtained. Histopathological assessment of gastric mucosa was done after staining with H and E stain and Giemsa stain. The histopathological diagnosis of Helicobacter pylori infection in biopsy specimen will be mainly done using the Modified Giemsa stain.Results: 105 patients with dyspepsia were studied in total. Out of which, 44 patients (41.9%) were detected positive for Helicobacter pylori infection.Conclusions: The burden of Helicobacter pylori infection in patients with dyspepsia was high. Early diagnosis and eradication of Helicobacter pylori not only improves symptoms but also help to prevent complications associated with Helicobacter pylori infections.
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Mirković, Andrea, and Nikola Savić. "Medical treatment and prevention of Helicobacter pylori infection." Sestrinska vizija 5, no. 9 (2021): 10–13. http://dx.doi.org/10.5937/sestrviz2109010m.
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Helicobacter pylori infection is one of the most commonly treated infections in gastroenterology. In the last three decades, due to recurrent or repeated infection, the incidence of this complex health problem has been constantly increasing. Studies have shown that successful treatment of this infection can prevent the occurrence of numerous complications, such as ulcer disease, dyspepsia or gastric cancer. Interventions in the prevention of Helicobacter pylori infection are numerous, they are carried out at all levels of health care and are of great importance for reducing the number of patients, but also for the occurrence of complications related to the infection. The aim of this paper is to evaluate innovations in medical treatment and prevention of Helicobacter pylori infection.
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Rengaswamy, Ramapriya, and Thayumanavan I. "Incidence and profile of Helicobacter pylori infection among HIV positive patients." International Journal of Advances in Medicine 5, no. 5 (September 22, 2018): 1299. http://dx.doi.org/10.18203/2349-3933.ijam20183912.
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Background: People having HIV infection present with a number of symptoms related to gastrointestinal tract like dyspepsia. HIV itself as well as opportunistic infections is responsible for such symptoms. Notably is Helicobacter pylori infection causes variety of such symptoms. The objective of the present research was to study incidence and profile of Helicobacter pylori among HIV positive patients.Methods: A hospital based cross sectional study was carried out over a period of two years among 101 HIV positive patients in the Department of General Medicine, Madurai Medical College, Madurai in collaboration with Department of Medical Gastroenterology and also Department of Venereology and Leporology. Rapid urease test was done. HIV status was confirmed by ELISA test. Data was analysed with the help of EPI statistical software.Results: Majority (40.6%) had CD4 count of 200-500. It has been observed that incidence of Helicobacter pylori was low in groups with low CD4 count. It was also observed that those with higher CD4 count had higher incidence of RUT positivity. This association was found to be statistically significant. The incidence of Helicobacter pylori positivity was not significantly different among those patients who were on ART (18%) and those who were not on ART (21%).Conclusions: The incidence of Helicobacter pylori infection was less in HIV positive patients. Those with CD4 cell count less than 100 had lower incidence of Helicobacter pylori infection than those with CD 4 cell count more than 500. Incidence of Helicobacter pylori infection was not affected by ART.
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Khoder, Ghalia, Sara Mina, Ibrahim Mahmoud, Jibran Sualeh Muhammad, Rania Harati, and Christophe Burucoa. "Helicobacter pylori Infection in Tripoli, North Lebanon: Assessment and Risk Factors." Biology 10, no. 7 (June 28, 2021): 599. http://dx.doi.org/10.3390/biology10070599.
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Helicobacter pylori (H. pylori) infection occurs among half of the general population worldwide, with high geographic variability. Even though H. pylori is the leading cause of several gastric diseases, ranging from gastritis and peptic ulcers to gastric malignancies, such as gastric cancer and mucosa-associated lymphoid tissue lymphoma, most of the infections remain asymptomatic. Early detection and eradication of H. pylori can definitely prevent severe long-term gastric diseases associated with H. pylori. In Lebanon, the prevalence of H. pylori is not well documented, especially in healthy subjects. The aim of this study is to assess H. pylori infections and the associated risk factors in Tripoli, North Lebanon. A cross-sectional study was conducted on 300 healthy Lebanese volunteers, including both children and adults. The H. pylori stool antigens were detected using the Premier Platinum HpSA test. The socio-demographic data, lifestyle characteristics, and gastrointestinal characteristics of all participants were analyzed. Out of the 300 tested volunteer subjects, 31% were found to be positive for H. pylori. A multivariate binary logistic regression analysis for factors associated with H. pylori infection revealed a significant association between H. pylori infection and gastrointestinal disturbances, the crowding index, and occupation. A significant statistical correlation was found between sheesha smoking (p = 0.001) and H. pylori infection. These findings highlight the need for the development of preventive approaches and strategic indications for the appropriate treatment of H. pylori infections in Tripoli, North Lebanon.
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Panov, Vladimir. "Endodontic infections and Helicobacter pylori." Journal of Medical and Dental Practice 11, no. 1 (May 21, 2024): 1817–21. http://dx.doi.org/10.18044/medinform.medinform.2024111.1817.
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Panov, Vladimir. "Endodontic infections and Helicobacter pylori." Journal of Medical and Dental Practice 11, no. 1 (May 21, 2024): 1817–21. http://dx.doi.org/10.18044/medinform.2024111.1817.
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Matos, Rita, Emily Taillieu, Sofie De Bruyckere, Chloë De Witte, Alexandra Rêma, Hugo Santos-Sousa, Jorge Nogueiro, et al. "Presence of Helicobacter Species in Gastric Mucosa of Human Patients and Outcome of Helicobacter Eradication Treatment." Journal of Personalized Medicine 12, no. 2 (January 29, 2022): 181. http://dx.doi.org/10.3390/jpm12020181.
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The genus Helicobacter is composed of bacteria that colonize both the human and animal gastrointestinal tract. Helicobacter pylori infects half of the world’s population, causing various disorders, such as gastritis, duodenitis and gastric cancer. Additionally, non-Helicobacter pylori Helicobacter species (NHPH) are commonly found in the stomach of pigs, dogs and cats. Most of these species have zoonotic potential and prevalence rates of 0.2–6.0%, and have been described in human patients suffering from gastric disorders undergoing a gastric biopsy. The aim of this study was to determine the occurrence of Helicobacter spp. in the stomach of patients with gastric cancer (n = 17) and obese (n = 63) patients. Furthermore, the outcome of the Helicobacter eradication treatment and the current infection status was evaluated. Overall, based on the genus-specific PCR followed by sequencing, DNA from Helicobacter spp. was detected in 46.3% of the patients, including single infections with H. pylori in 43.8% of the patients and mixed infections with H. pylori and canine- or feline-associated H. felis in 2.5%. About 32.5% of the patients had been subjected to previous Helicobacter eradication therapy and the triple standard therapy was the most frequent scheme (42.3%). In 48.0% of the patients who received eradication treatment, bacteria were still detected, including one mixed infection. In 23.1% of the patients who reported that a subsequent test had been performed to confirm the elimination of the bacteria, Helicobacter were still detected. In conclusion, although in a smaller percentage, NHPH may also be present in the human stomach. Thus, specific NHPH screening should be included in the diagnostic routine. The continued presence of H. pylori in the stomach of patients recently subjected to eradication schemes raises questions about the efficacy of the current Helicobacter treatments.
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BOCIAN, KATARZYNA M., and ELŻBIETA K. JAGUSZTYN-KRYNICKA. "The Controversy over Anti-Helicobacter pylori Therapy." Polish Journal of Microbiology 61, no. 4 (2012): 239–46. http://dx.doi.org/10.33073/pjm-2012-033.
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Helicobacter pylori is a Gram-negative spiral-shaped bacterium, member of epsilon-Proteobacteria specifically colonizing the gastric epithelium of humans. It causes one of the most common infections worldwide, affecting about half of the world's population. However, it should be noted that the prevalence of H. pylori, particularly in the Western world, has significantly decreased coinciding with an increase of some autoimmune and allergic diseases, such as asthma. Various epidemiological studies have also documented a negative association between H. pylori colonization and the presence of GERD (gastroesophageal reflux disease) and risk of esophageal cancer. Additionally, an upward trend of obesity recently observed in inhabitants of developed countries raised a question about the relationship between H. pylori infection and the human body mass index. The first part of this review describes common, recommended anti-H. pylori treatments. The second part, presents the results of recent experiments aimed at evaluating the association between H. pylori infections and gastro-esophageal diseases, the level of stomach hormones, the human body mass index and allergic diseases. Although some studies suggest an inverse association of H. pylori infection with some health problems of the modern world such as asthma, obesity or GERD, H. pylori should be considered as a harmful human pathogen responsible for serious and sometimes lethal diseases. Thus, many scientists advocate the eradication of H. pylori.
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Bumann, Dirk, Petra Holland, Frank Siejak, Jan Koesling, Nicolas Sabarth, Stefanie Lamer, Ursula Zimny-Arndt, Peter R. Jungblut, and Thomas F. Meyer. "A Comparison of Murine and Human Immunoproteomes of Helicobacter pylori Validates the Preclinical Murine Infection Model for Antigen Screening." Infection and Immunity 70, no. 11 (November 2002): 6494–98. http://dx.doi.org/10.1128/iai.70.11.6494-6498.2002.
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ABSTRACT Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.
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DIACONESCU, Smaranda, Marin BURLEA, Raluca STANCA, Monica ALEXOAE, and Ileana IONIUC. "Triple gastric ulcer in young child – case presentation." Romanian Journal of Medical Practice 10, no. 4 (December 31, 2015): 394–96. http://dx.doi.org/10.37897/rjmp.2015.4.14.
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Peptic ulcer is represented by loss of gastric or duodenal mucosal substance. It’s been considered a rare disease at the paediatric age. The main cause is represented by Helicobacter pylori infections or drugs administration. The authors present a case of nine-year-old child with triple gastric ulcer without Helicobacter pylori infection or prior treatment with nonsteroidal anti-inflammatory drugs or other medication with possible impact.
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Ullah, Zabih, Shaista Alam, Aurangzaib Khan, Munaza ,. Khattak, Zabih Ullah, Shabir Ahmed Orakzai, and Siyab Ahmed. "Frequency of H.Pylori in Liver Cirrhosis Patients with Overt Hepatic Encephalopathy: A Cross-Sectional Study Design." Pakistan Journal of Medical and Health Sciences 16, no. 11 (November 30, 2022): 745–47. http://dx.doi.org/10.53350/pjmhs20221611745.
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Objective: The study aim is to evaluate the frequency of H. pylori in Liver cirrhosis patients with overt HE. Place and duration of study: This Study is conducted in the department of Pathology, Peshawar Institute of Medical Sciences (PIMS) Peshawar and The duration of study is from Ist April, 2022 till 30th September, 2022. Material and Method: Cross sectional study design having sample size of 140 individuals suffering from H.pylori infections also having a history of hepatic insufficiency.Non-probability sampling technique is used, Patients having age greater than 30 years of any sex but having an history of hepatic cirrhosis for the last 5-6 months, ultrasounds for overt Hepatic encephalopathy are included in this study design. Sample participants having different age strata, disease duration and child’s pugh classification are expressed in means and standard deviation with the help of SPSS. Results: Patients having helicobacter pylori infection in hepatic cirrohsis with overt hepatic encephalopathy are 44(31.4%) and 96 (68.4%) patients have not suffering from any simultaneous infection. There are 65(46.4%) males and 75(53.6% ) females, The mean duration of disease in our study is 4.89+ 1.5 years. Stratification with duration of disease in years in shown in table 1, having significant result with p-value of 0.000. Startified findings of CP is found to be insignificant with H.Pylori infection(p-value=0.500). Practical Implications: According to this study, H pylori infection should be promptly assessed in all patients with liver cirrhosis. The patients' chances of developing hepatic encephalopathy and bleeding chances as a result of the H pylori infection. It may be possible to lessen the severity of consequences such bleeding from esophageal varices, portal hypertensive gastropathy, and hepatic encephalopathy with the early identification and subsequent eradication of H pylori infection. Conclusion: The conclusive remarks of this study shows the prevalence of less frequency of Helicobacter pylori infections in Liver cirrhosis in the patients of Pakistan. But, among all of them Helicobacter Pylori causes prolongation in duration of liver cirrhosis. This study also highlights that as aged patients with liver cirrhosis having more cases of having helicobacter pylori infection. Keywords: Hepatic Encephalopathy, Child’s Pugh Classification,Helicobacter Pylori infection, Liver insufficiency
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Sawleshwarkar, S., G. Eslick, C. Chung, R. Jones, and A. Mindel. "22. IS HELICOBACTER PYLORI A STI? - A PILOT STUDY." Sexual Health 4, no. 4 (2007): 293. http://dx.doi.org/10.1071/shv4n4ab22.
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Background: Helicobacter pylori is responsible for chronic gastritis and peptic ulcer disease and is associated with an increased risk of developing stomach cancer. The seroprevalence of Helicobacter pylori in the Australian-born adult population is about 20% and increases with age. The exact mode of transmission of Helicobacter pylori infection remains unknown and it has been suggested that sexual transmission may be important. This study is a preliminary investigation into a possible association between sexual risk factors and Helicobacter pylori infection. Subjects and methods: All patients aged 18 and above, presenting to the Parramatta Sexual Health Clinic and were having blood taken for any other purpose, were eligible for the study. Blood samples were collected for Helicobacter pylori serology using an enzyme-linked immunosorbent assay to detect Helicobacter pylori IgG. Demographic information and data regarding sexual behaviour and risk factors for sexually transmitted infections was obtained. The sample size to detect a 15% difference between the study population and the general Australian population with 90% power was 105. To allow for minor variations we plan to recruit 125 participants. Results: To date, 65 patients (75.4% males) have been enrolled in the study and 10 (7 males and 3 females) (15.4%) were positive for Helicobacter pylori. One additional result was equivocal. 24.6% of the participants were born outside Australia and out of 8 who belonged to middle and low-income countries, three had positive serology. The full results of the study, including seroprevalence and the demographic and sexual risk factors, will be presented.
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Mégraud, Francis, and Philippe Lehours. "Helicobacter pylori Detection and Antimicrobial Susceptibility Testing." Clinical Microbiology Reviews 20, no. 2 (April 2007): 280–322. http://dx.doi.org/10.1128/cmr.00033-06.
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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.
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Nkuize, Marcel, and Stéphane De Wit. "Issues Related to the Treatment of H. pylori Infection in People Living with HIV and Receiving Antiretrovirals." Microorganisms 10, no. 8 (July 29, 2022): 1541. http://dx.doi.org/10.3390/microorganisms10081541.
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Treatment of Helicobacter pylori infection in people living with HIV is associated with several challenges, including those related to drug metabolism which plays a major role in treatment efficacy. In this review, we will discuss the enzymes involved in the metabolism of anti-Helicobacter pylori and anti-HIV drugs to provide a basis for understanding the potential for interactions between these drug classes. We will also provide a clinical perspective on other issues related to the treatment of Helicobacter pylori and HIV infections such as comorbidities, adherence, and peer communication. Finally, based on our understanding of the interplay between the above issues, we propose a new concept “Antimicrobial susceptibility testing-drug interaction-supports-referent physician” (AISR), to provide a framework for improving rates of H. pylori eradication in people living with HIV.
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Hsu, Ping-Ning, and Woan-Yu Lin. "Modulation of TRAIL mediated apoptosis signaling by Helicobacter pylori." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 66.22. http://dx.doi.org/10.4049/jimmunol.196.supp.66.22.
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Abstract Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulcer and gastric cancer. However, the mechanisms by which cause disease remain unclear. Apoptosis induced by microbial infections is implicated in the pathogenesis of H. pylori infection. Here we show that human gastric epithelial cells sensitized to H. pylori confer susceptibility to TRAIL-mediated apoptosis via modulation of death receptor signaling. Human gastric epithelial cells are intrinsically resistant to TRAIL-mediated apoptosis. The induction of TRAIL sensitivity by H. pylori is dependent on the activation of caspase-8 and its downstream pathway. H. pylori induces caspase-8 activation via enhanced assembly of the TRAIL death-inducing signaling complex (DISC) through down-regulation of cellular FLICE-inhibitory protein (FLIP). Our study thus demonstrates H. pylori induces sensitivity to TRAIL apoptosis by regulation of FLIP and assembly of DISC, which initiates caspase activation, resulting in the breakdown of resistance to apoptosis, and provides insight into the pathogenesis of gastric damage in Helicobacter infection. We further demonstrated that FLIPS expression was consistent with Akt activation. H. pylori induced reduced Akt phosphorylation and led to decreased FLIPS expression in human gastric epithelial cells. Modulation of host apoptosis signaling by bacterial interaction adds a new dimension to the pathogenesis of Helicobacter.
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Paul, Bolai, Senthil Adimoolam, Mohd Javed Qureshi, and Nahlah Elkudssiah Ismail. "A REVIEW OF HELICOBACTER PYLORI INFECTION DISEASES, ANTIBIOTIC RESISTANCE AND DIAGNOSIS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (December 7, 2018): 566. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.24745.
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Objective: The aim of the study was designed to assess the mechanisms of antibiotic resistance in Helicobacter pylori, affecting disease by this infection and diagnostic methods which are used to detect H. pylori.Methods: A wide literature search was performed using PubMed, Medline, Cinahl, Embase, Educational Resources Information Center, PsycINFO, Google Scholar, Scopus, and Web of Science, and review of appropriate epidemiologic studies conducted from 1995 to 2017 for studies fully published investigating a contribution between H. pylori infection, antibiotic resistance, and diagnosis of H. pylori infection.Results: H. pylori infection is extremely contributed to the main symptoms and death that is currently affecting 50–75% of the people in the world. It is more affected in developing countries compared to developed countries. These infections are regarded to be the most important reasons for gastric cancer, peptic ulcer, chronic gastritis, duodenal ulcer, mucosa-associated lymphoid tissue lymphomas, and gastric adenocarcinoma. About 90–100% of duodenal ulcers and 60–90% of gastric ulcers were associated with H. pylori infections. At present, antibiotic resistance is a growing problem for the eradication of H. pylori infection; it contains metronidazole, amoxicillin, clarithromycin, and levofloxacin resistance. Diagnosis of H. pylori infection is a crucial part for the better treatment of those diseases. Different types of testing method for H. pylori infection are used including invasive (endoscopic image, histology, rapid urease test, and culture) and non-invasive (urea breath test, stool antigen test, and serological).Conclusion: H. pylori antibiotic resistance is the major contributor to the failure of H. pylori treatment. Appropriate diagnostic method selected in detecting H. pylori antibiotic resistance may lead to reduced treatment failures and less antibiotic resistance.
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Brady, R. C. "Persistent and Transient Helicobacter pylori Infections." AAP Grand Rounds 34, no. 5 (November 1, 2015): 58. http://dx.doi.org/10.1542/gr.34-5-58.
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Kusters, Johannes G., and Ernst J. Kuipers. "Non-pylori Helicobacter infections in humans." European Journal of Gastroenterology & Hepatology 10, no. 3 (March 1998): 239–42. http://dx.doi.org/10.1097/00042737-199803000-00009.
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Mégraud, Francis, and Philippe Lehours. "Helicobacter pylori : diagnostic bactériologique des infections." EMC - Biologie Médicale 1, no. 2 (January 2006): 1–4. http://dx.doi.org/10.1016/s2211-9698(06)76477-9.
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Mégraud, Francis. "Diagnostic des infections à Helicobacter pylori." Annales de l'Institut Pasteur / Actualités 6, no. 3 (January 1995): 179–84. http://dx.doi.org/10.1016/0924-4204(96)89256-0.
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Rimbara, Emiko, Lori A. Fischbach, and David Y. Graham. "Optimal therapy for Helicobacter pylori infections." Nature Reviews Gastroenterology & Hepatology 8, no. 2 (February 2011): 79–88. http://dx.doi.org/10.1038/nrgastro.2010.210.
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Graham, D. Y., and L. A. Fischbach. "Empiric therapies for Helicobacter pylori infections." Canadian Medical Association Journal 183, no. 9 (February 22, 2011): E506—E508. http://dx.doi.org/10.1503/cmaj.101460.
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Ly, A. "Infections à Helicobacter pylori et oncogenèse." Journal Africain du Cancer / African Journal of Cancer 2, no. 4 (October 18, 2010): 213–18. http://dx.doi.org/10.1007/s12558-010-0123-z.
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Hussein Al–Mousawi, Alia, Bent alhuda Hussein Neamah, Roaa Mohammed Chessab, Hadeel Haider Aldujaili, and Jannat Mohammed Chessab. "Relation Helicobacter pylori with Pathogenesis of Stomach and Immune Responses." Medical Science Journal for Advance Research 3, no. 2 (June 29, 2022): 55–60. http://dx.doi.org/10.46966/msjar.v3i2.41.
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Background: Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen. The prevalence of H. pylori infections varies worldwide. prevalence among middle-aged adults is over 80 percent in many developing countries, as compared with 20 to 50 percent in industrialized countries. The infection is acquired by oral ingestion of the bacterium and is mainly transmitted within families in early childhood, Humans can also become infected with Helicobacter heilmannii, a spiral bacterium found in dogs, cats, pigs, and nonhuman primates.
Conclusion: H. pylori infection stimulates the reaction of autoantibodies with gastric epithelial cells, and this leads to gastritis. These autoantibodies can be directly induced to epithelial cells by activating complement, inducing apoptosis or provoking an antibody-dependent cytotoxic reaction resulting in subsequent tissue destruction.
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Sharma, Pasanda, Samyog Adhikari, Shreesuna Katila, Aashra Bajracharya, Nidhi Bohara, Sujan Pathak, Priyanka Poudel, and Prakash Sapkota. "Helicobacter pylori Infection among Patients Undergoing Upper Gastrointestinal Endoscopy in a Tertiary Care Center." Journal of Nepal Medical Association 62, no. 269 (January 2, 2024): 5–8. http://dx.doi.org/10.31729/jnma.8393.
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Introduction: Helicobacter pylori is a gram-negative gut bacterium associated with dyspepsia, peptic ulcer disease, and gastric cancer, whose prevalence is still common in developing countries. Upper gastrointestinal endoscopy is the gold standard, first-line investigation for evaluating gastrointestinal disorders. The aim of the study was to find out the prevalence of Helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in a tertiary health care centre among the patients undergoing upper gastrointestinal endoscopy from 5 January 2020 to 5 January 2023 after obtaining ethical approval from the Institutional Review Committee. Convenience sampling method was used. The point estimate was calculated at a 99% Confidence Interval. Results: Among 1,975 patients, Helicobacter pylori infection was found in 561 (28.41%) (25.79-31.03, 99% Confidence Interval). The indication for upper gastrointestinal endoscopy was mostly dyspepsia 256 (45.68%) followed by abdominal pain 205 (36.54%). The most common endoscopic finding was gastritis 445 (79.32%) followed by hiatal hernia 93 (16.58%). The commonest biopsy finding was chronic active gastritis 478 (85.20%). Conclusions: The prevalence of Helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy was found to be similar to other studies done in similar settings. The persistence of H. pylori emphasizes the need of continuous research to address ever evolving H. pylori infections and resistance that are developing against available treatment modalities.
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Odigie, A. O., A. J. Adewole, and A. A. Ekunwe. "Prevalence and factors associated with Helicobacter pylori infection among treatment naïve dyspeptic adults in University of Benin Teaching Hospital, Benin City, Nigeria." African Journal of Clinical and Experimental Microbiology 21, no. 2 (February 17, 2020): 97–105. http://dx.doi.org/10.4314/ajcem.v21i2.3.
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Background: Infectious diseases such as malaria, HIV/AIDS and tuberculosis have received tremendous attention globally but inspite of the widespread nature of infections caused by Helicobacter pylori, little attention has been paid to it especially in the developing countries. The objective of this study was to determine the prevalence of and factors associated with H. pylori infection among dyspeptic patients attending the University of Benin Teaching Hospital, Benin City, Nigeria. Methodology: This was a hospital based descriptive cross-sectional study of 354 treatment naive dyspeptic patients aged 18 to 44 years, recruited consecutively after obtaining institutional ethical approval and subjects’ informed consent. A pre-tested interviewer administered questionnaire was used to obtain subjects’ data. The stool antigen test was used to detect H. pylori infection. Results: The prevalence of H. pylori infection among the subject participants was 34.2% (38.4% in female, 24.0% in male, p=0.009). The age group < 20 years had the highest prevalence of 40%. Gender, occupation, increased body mass index, high number of household occupants, and rural dwelling, were significantly associated with H. pylori infection (p<0.05) and alcohol intake was inversely related to H. pylori infection (p<0.05). Conclusion: The prevalence of H. pylori infection in University of Benin Teaching Hospital is high and factors such as gender, obesity, occupation with risk of contact, low socio-economic status, and poor hygiene, may be responsible for this.Keywords: Dyspepsia, Helicobacter pylori, infection, stool antigen test
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Gomez-Ramirez, Uriel, Carolina G. Nolasco-Romero, Araceli Contreras-Rodríguez, Gerardo Zuñiga, Sandra Mendoza-Elizalde, Francisco-Javier Prado-Galbarro, Fernando Pérez Aguilar, Jonatan Elihu Pedraza Tinoco, Pedro Valencia-Mayoral, and Norma Velázquez-Guadarrama. "Dysbiosis by Eradication of Helicobacter pylori Infection Associated with Follicular Gastropathy and Pangastropathy." Microorganisms 11, no. 11 (November 10, 2023): 2748. http://dx.doi.org/10.3390/microorganisms11112748.
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Dysbiosis plays an important role in the development of bacterial infections in the gastric mucosa, particularly Helicobacter pylori. The international guidelines for the treatment of H. pylori infections suggest standard triple therapy (STT). Nevertheless, because of the increasing resistance rates to clarithromycin, metronidazole has been widely considered in several countries. Unfortunately, the non-justified administration of antibiotics induces dysbiosis in the target organ. We characterized the gastric microbiota of patients diagnosed with follicular gastropathy and pangastropathy attributed to H. pylori infection, before and after the administration of STT with metronidazole. Dominant relative abundances of Cutibacterium were observed in pre-treatment patients, whereas H. pylori was observed at <11%, suggesting the multifactor property of the disease. The correlation of Cutibacterium acnes and H. pylori with gastric infectious diseases was also evaluated using quantitative real-time polymerase chain reaction. The dominance of C. acnes over H. pylori was observed in gastritis, gastropathies, and non-significant histological alterations. None of the microorganisms were detected in the intestinal metaplasia. Post-treatment alterations revealed an increase in the relative abundances of Staphylococcus, Pseudomonas, and Klebsiella. Non-H. pylori gastrointestinal bacteria can be associated with the initiation and development of gastric diseases, such as pathobiont C. acnes.
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Choi, Jiwoong, and Jihun Kang. "Concurrence of Helicobacter pylori Infection and Its Associated Factors in Korean Couples." Korean Journal of Family Medicine 43, no. 1 (January 20, 2022): 77–82. http://dx.doi.org/10.4082/kjfm.21.0115.
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Background: This study evaluated the prevalence of Helicobacter pylori infection and the risk factors associated with H. pylori transmission among spouses.Methods: We assessed the spousal concurrence of H. pylori infection using the Campylobacter-like organism (CLO) test under gastro-endoscopy in 132 couples. Based on the CLO test results, participants were categorized into H. pylori concurrent and independent groups. The chi-square test and Student t-test were performed for demographic comparisons between the concurrent and independent H. pylori groups. In addition, multivariate logistic regression analysis was performed to identify factors associated with concurrent H. pylori infection.Results: The study revealed that the concurrence rate of H. pylori infection was 42.4% in married Korean couples. The odds ratio (OR) derived from the concurrence of H. pylori infection tended to decrease in older couples (OR, 0.975; 95% confidence interval [CI], 0.949–1.002; P=0.072). Gastric erosion was also associated with a decreased OR for concurrent infection (OR, 0.488; 95% CI, 0.295–0.808; P=0.005). Conversely, active duodenal ulcers were associated with an increased OR for concurrent infections (OR, 6.501; 95% CI, 1.267–33.346; P=0.025). Duodenal ulcer scars tended to increase the OR of concurrent infections (OR, 1.392; 95% CI, 0.815–2.380; P=0.226).Conclusion: Spousal transmission and concurrence of H. pylori infection were negatively associated with gastric erosion; however, they were positively associated with active duodenal ulcers. Further studies are warranted to elucidate the mechanisms underlying these findings.
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Ikezawa, Kazuto, Takeshige Kanamori, Kentaro Iwai, Kouichirou Otsuka, Mariko Kobayashi, Daisuke Ochi, Hiroaki Sugiyama, Hideo Suzuki, and Atsuko Soeda. "Helicobacter pylori infection in rehabilitation staff younger than 35 years: Infection surveillance for three years." Journal of Infection Prevention 20, no. 5 (June 5, 2019): 240–45. http://dx.doi.org/10.1177/1757177419852669.
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Background: Screening for Helicobacter pylori infection is important because of the high risk of gastric cancer development. The H. pylori carrier rate among elderly Japanese patients is still high; therefore, rehabilitation (RH) workers who are in frequent contact with such individuals could be assumed to be at a higher risk of H. pylori infection. Aim/Objective: We surveyed RH workers to investigate the initial occurrence of H. pylori infections in adults. Methods: Urine samples of RH workers aged < 35 years were screened for H. pylori antibodies to confirm infection. H. pylori infection rates were stratified according to the type of RH work and duration of employment. Infection surveillance was performed at six-month intervals for H. pylori-negative individuals. Findings/Results: The H. pylori infection rate among 173 workers was 16.8%. Infection rates were 26.3%, 16.3% and 15.3% among speech, occupational and physiotherapists, respectively. The employment duration was divided into < 24, 24–47, 48–60 and ⩾ 61 months; the respective infection rates were 5.0%, 12.0%, 17.6% and 28.6%. However, no new H. pylori infection was detected in a total of seven surveillance studies of H. pylori-negative workers over a three-year period. Discussion: The results of the initial examination showed that the infection rate increased with the duration of employment. However, subsequent surveillance detected no new H. pylori infections.
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Precious Chinyere Alubi, Blessing Jachinma Okonko, Cynthia Chizoba Ogbuji, Edith Ijeego Mbah, and Iheanyi Omezuruike Okonko. "Serological prevalence of Herpes Simplex Virus, Syphilis, and H. pylori co-infections amongst HIV-infected individuals receiving care in a secondary healthcare facility in Port Harcourt, Nigeria." International Journal of Multidisciplinary Research Updates 5, no. 2 (April 30, 2023): 001–16. http://dx.doi.org/10.53430/ijmru.2023.5.2.0053.
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Helicobacter pylori is a widespread pathogen that significantly contributes to dyspeptic disease and gastric cancer. There are conflicting prevalence patterns of H. pylori in HIV-1-infected patients. Although the interaction between HIV and H. pylori infection is not well investigated, previous studies have suggested a decreased prevalence of H. pylori and the limited effectiveness of eradication treatment in HIV-positive individuals. Therefore, this study aimed to describe the serological prevalence of HIV/HSV, HIV/Syphilis, and HIV/H. pylori co-infection among HIV-infected individuals receiving care in a secondary healthcare facility in Port Harcourt, Nigeria. In the study, 100 HIV-infected individuals were screened for HSV, syphilis and H. pylori co-infections. Co-infections were 0.0% for HIV/HSV, 0.0% for HIV/Syphilis and 58.0% for HIV/Helicobacter pylori. Higher prevalence of HIV/H. pylori co-infection occurred among the age group <20-40 (59.5%), males (59.5%), unemployed (100.0%), Ahaoda, Eleme and Etche LGAs, and high CD4 counts of 200-349 and >350 cells/µl (58.3%) compared to other categories. This study confirmed the absence of HSV and syphilis among these participants. It further indicated that co-infection of HIV/H. pylori were high (58.0%), although the underlying mechanisms remained unknown. However, the H. pylori co-infection in HIV-infected individuals was associated (P>0.05) with CD4+ cell counts and any socio-demographic variables evaluated. However, more studies are needed on these patients in Rivers State, Nigeria, to evaluate the infection rate further.
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MINA, Sara, Sara Daher, Nour Mina, and Ghalia Khoder. "Concomitant Infection of Helicobacter pylori and Intestinal Parasites: Burden, Sociodemographic and Clinical Characteristics in Hospitalized Children and Adolescents in Northern Lebanon." F1000Research 13 (May 17, 2024): 500. http://dx.doi.org/10.12688/f1000research.148550.1.
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Background Helicobacter pylori and intestinal parasites are well-known for their high prevalence in children, especially in developing countries. However, their concomitant infections are poorly documented. In this study, we aimed to evaluate the association between intestinal parasites and H. pylori among hospitalized children and adolescents with upper gastrointestinal complaints in Northern Lebanon. Methods A cross-sectional study was conducted involving 297 hospitalized pediatric patients, aged between 1 and 15 years, who presented with gastrointestinal symptoms. The socio-demographic, lifestyle, and gastrointestinal characteristics of all participants were analyzed. Fresh stool samples were collected and screened for the presence of intestinal parasites and H. pylori infections. Results 6.4% of the patients were positive for intestinal parasitic infections, 5.4% were positive for H. pylori infection, and 11.8% were co-infected. The results of the Chi-square test showed that H. pylori infection is significantly associated with parasitic infection but not with a particular species. The most frequent coinfection was H. pylori-Entamoeba histolytica (77.1%). Moreover, H. pylori infection was associated with overcrowding and infrequent washing of vegetables before eating. The prevalence of co-infections increased in patients of mothers with a primary educational level or less. In regards to clinical characteristics, our findings showed a statistically significant relationship between i) gastric reflux and H. pylori, and ii) severe diarrhea and parasitic infection. Conclusion Our data highlighted the association between H. pylori and intestinal parasitic infections. Thus, H. pylori detection could be taken into consideration while screening for parasitic infections in children and adolescents.
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Karim, Rashid, Wajid Iqbal, Mahwash Mengal, Muhammad Alam Mengal, Muhammad Mohsin Sial, and Ahmed Latif Chaudhary. "Infection with Helicobacter Pylori and the Risk of Iron Deficiency Anaemia." Pakistan Journal of Medical and Health Sciences 17, no. 5 (June 23, 2023): 253–55. http://dx.doi.org/10.53350/pjmhs2023175253.
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Objective: The objective of this research is to determine the frequency of a condition known as iron deficiency anaemia (IDA) among people who have been infected with Helicobacter pylori. Study Design: Cross-sectional/ Prospective study Place and Duration: Hayatabad Medical Complex Peshawar in the duration from November, 2022 to April, 2023. Methods: There were a total of 116 patients with Helicobacter pylori infections, whose ages ranged from 20 to 70. After collecting demographic information from each participant (including age, sex, BMI, education level, and residence), each patient gave written informed consent. Subjects' blood was tested for iron, transferrin saturation, ferritin, which and total iron-binding capacity. Histopathology, stool antigen testing, a fast urease test, and a urea breath test can all diagnose Helicobacter pylori infection. All statistical analyses were performed in SPSS 25.0. Results: There were 74 (63.8%) females and 42 (36.2%) males in our study. Patients mean age was 28.13±14.68 years and had mean BMI 23.6±11.26 kg/m2. The mean Hemoglobin level of the patients was 11.9±1.8 (g/dl), the iron level was 47.11±6.49 (ug/dl) and mean ferritin level was 119.6±32.68 (ng per ml). Among 116 cases, 42 (36.2%) patients had Iron Deficiency Anemia (IDA). Conclusion: An increased incidence of iron deficiency anaemia was seen among individuals with Helicobacter pylori infections; the majority of these patients were adult females. Keywords: H.pylori infection, Prevalence, Iron Deficiency Anemia (IDA),
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Chichirau, Diechler, Posselt, and Wessler. "Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer." Toxins 11, no. 10 (October 11, 2019): 591. http://dx.doi.org/10.3390/toxins11100591.
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Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in H. pylori-mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in H. pylori pathogenesis are summarized.
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Ben Mahmoud, Lobna, Hanène Ghozzi, Ahmed Hakim, Zouheir Sahnoun, and Khaled Zeghal. "Helicobacter pylori associated with chronic urticaria." Journal of Infection in Developing Countries 5, no. 08 (July 5, 2011): 596–98. http://dx.doi.org/10.3855/jidc.1363.
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Chronic urticaria is one of the most frequent skin diseases in medical practice. Urticaria is defined as acute if the whealing persists for less than six weeks and as chronic if it persists for longer. Chronic urticaria that lasts for several years to decades significantly impairs the quality of life. There is evidence that Helicobacter pylori has a critical role in different extragastric diseases such as chronic urticaria. We present a case of chronic urticaria in an adult patient with H. pylori infection and disease regression after triple anti-H. pylori therapy. In contrast to the autoimmune mechanisms involved in chronic urticaria against which no specific treatment strategy has been developed, infections with H. pylori could be treated with triple therapy. It is suggested that laboratory tests for the detection of this pathogen should be performed in patients with chronic urticaria.
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Mutia, Chairani, Lubis Masrul, and Rey Imelda. "Risk Factors of Helicobacter Pylori Infection in Samosir Island." International Journal of Research and Review 10, no. 7 (July 19, 2023): 453–59. http://dx.doi.org/10.52403/ijrr.20230755.
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Introduction. Helicobacter pylori infection mostly associated with gastrointestinal disease such as gastritis, peptic ulcer, duodenal ulcer, and gastric adenocarcinoma. Route of transmission of H. pylori are not fully understood, but human-to-human transmission via oral-oral or fecal-oral route is considered the most likely route. Prevalence of this bacterial infection also varies between countries, Indonesia itself has a fairly low prevalence of H. pylori infection at rate of 22.1%. This study aims to determine the prevalence and risk factors of H. pylori infection among Batak ethnicity in Samosir Island. Method. A cross-sectional study was conducted from March – May 2021 to determine the prevalence and risk factors of H. pylori infections in Samosir Island through stool antigen test (SAT) examination. Results. A total of 100 patients reside in Boho Village, Samosir Island enrolled in this study. All of the subjects were tested for H. pylori infection with SAT. The study also collected data using the questionnaire method, and obtained data on age, gender, occupation, education level, history of smoking and alcohol consumption, nutritional status, and also H. pylori diagnostic test results. Conclusion. Prevalence of H. pylori infection in Samosir Island based on SAT is 18% with the risk factors that are significantly associated with environmental sanitation (p=0.001) and personal hygiene (p=0.004). Keywords: H. pylori, Batak Ethnicity, Stool Antigen Test
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Marginean, Cristina Maria, Ramona Cioboata, Mihai Olteanu, Corina Maria Vasile, Mihaela Popescu, Alin Iulian Silviu Popescu, Simona Bondari, et al. "The Importance of Accurate Early Diagnosis and Eradication in Helicobacter pylori Infection: Pictorial Summary Review in Children and Adults." Antibiotics 12, no. 1 (December 29, 2022): 60. http://dx.doi.org/10.3390/antibiotics12010060.
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Among the most widespread childhood infections, Helicobacter pylori (H. pylori) develops potentially life-threatening conditions in adults if not appropriately treated. Helicobacter pylori is a common human pathogen that was first described in the stomach many years ago. The discovery of H. pylori was crucial in gastroenterology; this bacterium is associated with chronic gastritis, peptic ulcers, gastric cancer, and lymphoid tissue lymphoma related to the gastric mucosa. Studies published so far estimate that approximately 10% of subjects infected with H. pylori develop a peptic ulcer, and 1–3% of subjects develop gastric cancer. The clinical manifestations are variable and characteristically depend on the individual factors of the host. Various methods of detection and diagnosis of H. pylori infection have been developed, each with advantages, disadvantages, and/or limitations. Available diagnostic tests are usually performed using invasive (endoscopy, biopsy, rapid urease test, cultures, and molecular tests) and noninvasive methods (urea breath test, stool antigen examination, and serological and molecular tests). Although there is extensive accessibility for diagnosing and treating H. pylori infection, the prevalence of antibiotic resistance is not negligible. Thus, numerous studies and meta-analyses are focused on a new orientation of gastroenterologists in diagnosing and treating H. pylori infections. A fascinating perspective hypothesis is the administration of probiotics to reduce H. pylori adhesion to gastric epithelial cells, preventing H. pylori colonization, especially in children, or reinfection with H. pylori in high-risk adult patients.
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Roszczenko-Jasińska, Paula, Marta Ilona Wojtyś, and Elżbieta K. Jagusztyn-Krynicka. "Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets." Applied Microbiology and Biotechnology 104, no. 23 (October 14, 2020): 9891–905. http://dx.doi.org/10.1007/s00253-020-10945-w.
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Abstract Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen. The prevalence of H. pylori infections varies worldwide. The H. pylori genotype, host gene polymorphisms, and environmental factors determine the type of induced disease. Currently, the most common therapy to treat H. pylori is the first line clarithromycin–based triple therapy or a quadruple therapy replacing clarithromycin with new antibiotics. Despite the enormous recent effort to introduce new therapeutic regimens to combat this pathogen, treatment for H. pylori still fails in more than 20% of patients, mainly due to the increased prevalence of antibiotic resistant strains. In this review we present recent progress aimed at designing new anti-H. pylori strategies to combat this pathogen. Some novel therapeutic regimens will potentially be used as an extra constituent of antibiotic therapy, and others may replace current antibiotic treatments. Key points • Attempts to improve eradication rate of H. pylori infection. • Searching for new drug targets in anti-Helicobacter therapies.
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Veijola, Lea, Aino Oksanen, Pentti Sipponen, and Hilpi Rautelin. "Evaluation of a Commercial Immunoblot, Helicoblot 2.1, for Diagnosis of Helicobacter pylori Infection." Clinical and Vaccine Immunology 15, no. 11 (September 30, 2008): 1705–10. http://dx.doi.org/10.1128/cvi.00165-08.
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ABSTRACT The best method to diagnose Helicobacter pylori infection in different clinical situations is controversial. The aim of the study was to assess the performance of a commercial immunoblot, Helicoblot 2.1. The study comprised 215 patients, who were grouped according to the presence of H. pylori infection (assessed by two gastroscopies including histology with a median interval of 7.1 years, enzyme immunoassay [EIA]-based serology, and history of previous H. pylori infections and eradication therapies) into four categories: no H. pylori infection ever, previous infection, ongoing infection, and EIA seropositivity as the only marker of a possible previous infection. The sensitivity of Helicoblot 2.1 to show an ongoing or previous H. pylori infection was 100% and 92%, respectively. Helicoblot 2.1 was negative in only 80% of individuals with no evidence of present or previous infection but in 96% of patients 50 years of age or younger. The current infection marker of the immunoblot was positive in 49% of patients with successful H. pylori eradication therapy. After successful eradication therapy, Helicoblot 2.1 sustained positive results in 87% of patients, and CagA positivity was detected in 87% of patients with follow-up samples for more than 10 years after therapy. Helicoblot 2.1 is a sensitive and, among patients of ages 50 years or younger, a specific test in the primary diagnosis of H. pylori infection. However, it does not discriminate between past and current infections. It can be used in epidemiological studies assessing the role of H. pylori in different late sequelae.
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L., Ebidor, Alade T., and Ujile L. M. "Helicobacter Pylori and Intestinal Parasites Co-infection in Pregnant Women Attending Antenatal Clinic in a Hospital, South-South Nigeria." African Journal of Biology and Medical Research 7, no. 1 (February 5, 2024): 1–8. http://dx.doi.org/10.52589/ajbmr-rf8mto4g.
Full textAbstract:
Pregnant women are susceptible to severe health problems caused by Helicobacter pylori and intestinal parasitic infections. These conditions include iron deficiency anaemia, hyperemesis gravidarum, gastritis, duodenal ulcers, and maternal morbidity and mortality. These infections usually spread due to poor personal hygiene and socioeconomic conditions. The study aimed to investigate the occurrence of H. pylori and intestinal parasitic infections amongst pregnant women attending the antenatal clinic in Okolobiri, Bayelsa State. We analysed the samples using the H. pylori antibody rapid tests, stool direct wet mounts, formal ether concentration, and saturated sodium chloride floatation. The data revealed that 34% of the women were infected with H. pylori and 20% with intestinal parasites. The highest occurrence of H. pylori infection and intestinal co-infection was in the 26-30 age group. Entamoeba histolytica was the most common type of protozoa present, while Ascaris lumbricoides and Trichuris trichuria were the most common forms of helminth infections. The Chi-square analysis showed a statistically significant difference with respect to age. These results provide essential epidemiological data on the prevalence of H. pylori and intestinal parasitic infections among pregnant women in Okolobri, Bayelsa State. The study highlights the need to screen pregnant women for H. pylori and intestinal parasites to improve antenatal care for both mother and child.