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Academic literature on the topic 'Hedgehog'

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Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "Hedgehog"

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Rasmussen, Sophie Lund, Bettina Thuland Schrøder, Anne Berger, Rahel Sollmann, David W. Macdonald, Cino Pertoldi, and Aage Kristian Olsen Alstrup. "Testing the Impact of Robotic Lawn Mowers on European Hedgehogs (Erinaceus europaeus) and Designing a Safety Test." Animals 14, no. 1 (December 29, 2023): 122. http://dx.doi.org/10.3390/ani14010122.

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Previous research has established that some models of robotic lawn mowers are potentially harmful to hedgehogs. As the market for robotic lawn mowers is expanding rapidly and the populations of European hedgehogs (Erinaceus europaeus) are in decline, it is important to investigate this risk further to understand the potential threat which some robotic lawn mowers may pose to hedgehogs. We tested 19 models of robotic lawn mowers in collision with hedgehog cadavers to measure their effect on hedgehogs. Our results showed that some models of robotic lawn mowers may injure hedgehogs, whereas others are not harmful to them. Apart from one single incidence, all robotic lawn mowers had to physically touch the hedgehog carcasses to detect them. Larger hedgehog cadavers were less likely to be “injured”, with height being the most influential measure of size. The firmness of the tested hedgehog cadavers (frozen or thawed) did not influence the outcome of the collision tests. Neither the position of the hedgehog cadavers nor the selected technical features of the lawn mowers affected the probability of injury. Based on the results, we designed a standardised safety test to measure the effect of a specific model of robotic lawn mower on hedgehogs.
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Kirillov, Alexander, Nadezhda Kirillova, and Alexander Ruchin. "Helminths of Erinaceus roumanicus (Eulipotyphla, Erinaceidae) in Mordovia (Russia) with an Overview of Helminth Fauna of Erinaceus spp. Inhabiting the Palaearctic Region." Diversity 14, no. 3 (February 25, 2022): 165. http://dx.doi.org/10.3390/d14030165.

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The helminth fauna of the Northern white-breasted hedgehog Erinaceus roumanicus was studied in the Republic of Mordovia (Russia) for the first time. In total, 9 species of helminths were found in 23 studied hedgehogs: Trematoda—Isthmiophora melis, Strigea strigis (metacercaria); Cestoda—Hymenolepis erinacei; Nematoda—Aonchotheca erinacei, Physaloptera clausa, Crenosoma striatum, Physocephalus sexalatus (juvenile), Agamospirura minuta (juvenile); and Acanthocephala—Nephridiorhynchus major. Four parasite species (the trematode I. melis, nematodes P. sexalatus, A. minuta, and the acanthocephalan N. major) were found in hedgehogs for the first time in Russia. An overview of the helminth fauna of four species of Erinaceus hedgehogs inhabiting the Palearctic region is given. A total of 54 parasite species were recorded across Erinaceus europaeus, E. roumanicus, E. concolor and E. amurensis: 14 trematodes, 6 cestodes, 27 nematodes, and 7 acanthocephalans. Among all the studied species of hedgehogs, E. europaeus (35 species) and E. roumanicus (36) have the richest helminth faunas. The diversity of the parasite communities of Erinaceus spp. is due to the wide distribution and varied diet of these mammals. Most of the helminths found in hedgehogs are transmitted along trophic chains. Hedgehogs are the final hosts for 39 species of parasites. For 15 helminth species, Erinaceus spp. are paratenic hosts. The majority of the hedgehog’s helminth fauna is formed by host-specific parasites, of which there are 13 species. Most of the hedgehog’s parasites in the Palaearctic are facultative (non-specific) species that parasitize in various vertebrate species. The helminth fauna of Erinaceus hedgehogs is most studied in Russia and Belarus, where 17 species of parasites are found in each country. The comparative analysis of the helminth faunas of Erinaceus spp. from various regions showed, on the one hand, the originality of the helminth fauna of each hedgehog species and, on the other, the similarity of the helminth fauna of these insectivores from various countries of the Palaearctic. These features are caused by similar lifestyles and diet peculiarities of every hedgehog species in various regions of the Palaearctic. A total of 12 of the 54 helminth species found in hedgehogs have medical and veterinary significance as causative agents of dangerous helminthiasis.
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Yarnell, Richard W., and Carly E. Pettett. "Beneficial Land Management for Hedgehogs (Erinaceus europaeus) in the United Kingdom." Animals 10, no. 9 (September 3, 2020): 1566. http://dx.doi.org/10.3390/ani10091566.

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Hedgehogs (Erinaceus europaeus) are traditionally thought of as being a rural dwelling species, associated with rural and agricultural landscapes across Europe. However, recent studies have highlighted that hedgehogs are more likely to be found in urban than rural habitats in the United Kingdom. Here, we review the status of rural hedgehog populations across the UK and evaluate the potential benefits of agri-environment schemes for hedgehog persistence, while highlighting a lack of empirical evidence that agri-environment options will benefit hedgehog populations. Our synthesis has implications for future conservation strategies for hedgehogs and insectivorous mammals living in agricultural landscapes, and calls for more empirical studies on agri-environment options and their potential benefits to hedgehogs.
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Marco-Tresserras, Jana, and Germán M. López-Iborra. "Nesting Ecology of European Hedgehogs (Erinaceus europaeus) in Urban Areas in Southeast Spain: Nest Habitat Use and Characteristics." Animals 13, no. 15 (July 29, 2023): 2453. http://dx.doi.org/10.3390/ani13152453.

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Appropriate nesting sites are needed for the presence of European hedgehogs (Erinaceus europaeus) in an area, along with food availability. However, little attention has been paid to them in the literature. This study aimed at analysing, for the first time, the environmental characteristics of nesting sites chosen by hedgehogs, their spatial distribution and the effect of sex and season on them in two types of urban parks in southeastern Spain. A total of 31 hedgehogs were equipped with GPS devices, and 130 hedgehog nests were located and described. Both sexes had a similar number of nests; however, the spatial distribution of the male nests was larger, and they changed nests more frequently than females. The environment around the nests and hosting structures used also differed between the sexes, with males using a higher variety of nesting structures available and females being more selective. The differences in topography and habitat composition of the two urban parks also affected hedgehog nesting ecology, especially in reference to artificial elements like cat feeders. Further studies of nest locations at a microhabitat level are needed to contribute to a better understanding of a hedgehog’s requirements, fostering the design of more effective conservation strategies.
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Ekker, S. C., L. L. McGrew, C. J. Lai, J. J. Lee, D. P. von Kessler, R. T. Moon, and P. A. Beachy. "Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis." Development 121, no. 8 (August 1, 1995): 2337–47. http://dx.doi.org/10.1242/dev.121.8.2337.

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The hedgehog family of signaling proteins is associated with a variety of spatial patterning activities in insects and vertebrates. Here we show that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites. Banded hedgehog is expressed throughout the neural plate and subsequently in both the nervous system and in the dermatome of somites. Cephalic hedgehog is expressed in anterior ectoderm and endodermal structures, and sonic hedgehog is expressed in patterns which parallel those in other species. Injection of RNAs encoding Xenopus hedgehogs induces ectopic cement gland formation in embryos. Similar to reported activities of noggin and follistatin, Xenopus hedgehogs share a common ability to induce cement glands in animal cap explants. However, hedgehog activities in naive ectoderm appear capable of acting independently of noggin and follistatin since, although all three are induced by activin in animal cap explants, X-hh expression does not induce noggin or follistatin.
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Grzesiakowska, Anna, Przemysław Baran, Marta Kuchta-Gładysz, and Olga Szeleszczuk. "Cytogenetic karyotype analysis in selected species of the Erinaceidae family." Journal of Veterinary Research 63, no. 3 (September 13, 2019): 353–58. http://dx.doi.org/10.2478/jvetres-2019-0041.

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Abstract Introduction Comparative analysis of the karyotype structure was made in two hedgehog species: the northern white-breasted hedgehog (Erinaceus roumanicus) and the African pygmy hedgehog (Atelerix albiventris). Material and Methods The cytogenetic analysis used differential staining techniques (DAPI, Ag-NOR, and C-banding/DAPI) and sequential QFQ/FISH banding with NOR20 and TEL20 probes which showed 45S rDNA and (TTAGGG)n repeat sequences, respectively, on hedgehog chromosomes. Results It was confirmed that the somatic cells of the hedgehogs have a constant number of chromosomes (2n = 48,XY). Differences were observed in the NOR number between the species. NORs were identified on three autosome pairs in the northern white-breasted hedgehog and on only two pairs in the African pygmy hedgehog. Chromosome analysis by C-banding/DAPI showed large segments of heterochromatin rich in A-T pairs on three autosome pairs in both the northern white-breasted and African pygmy hedgehogs. The heterochromatin segments encompassed large fragments of the longer arm of chromosome pairs 13, 14 and 20. The (TTAGGG)n repeat sequences on the hedgehog chromosomes were only observed in the terminal position of all the chromosomes in both species. Conclusion Our observations provide new information on the level of diversity within the Erinaceidae family.
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Taucher, Anouk L., Sandra Gloor, Adrian Dietrich, Madeleine Geiger, Daniel Hegglin, and Fabio Bontadina. "Decline in Distribution and Abundance: Urban Hedgehogs under Pressure." Animals 10, no. 9 (September 9, 2020): 1606. http://dx.doi.org/10.3390/ani10091606.

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Increasing urbanization and densification are two of the largest global threats to biodiversity. However, certain species thrive in urban spaces. Hedgehogs Erinaceus europaeus have been found in higher densities in green areas of settlements as compared to rural spaces. With recent studies pointing to dramatically declining hedgehog numbers in rural areas, we pose the question: how do hedgehogs fare in urban spaces, and do these spaces act as refuges? In this study, recent (2016–2018) and past (1992) hedgehog abundance and distribution were compared across the city of Zurich, Switzerland using citizen science methods, including: footprint tunnels, capture-mark recapture, and incidental sightings. Our analyses revealed consistent negative trends: Overall hedgehog distribution decreased by 17.6% ± 4.7%, whereas abundance declined by 40.6% (mean abundance 32 vs. 19 hedgehogs/km2, in past and recent time, respectively), with one study plot even showing a 91% decline in this period (78 vs. 7 hedgehogs/km2, respectively). We discuss possible causes of this rapid decline: increased urban densification, reduction of insect biomass, and pesticide use, as well as the role of increasing populations of badgers (a hedgehog predator) and parasites or diseases. Our results suggest that hedgehogs are now under increasing pressure not only in rural but also in urban areas, their former refuges.
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Gazzard, Abigail, and Philip J. Baker. "Patterns of Feeding by Householders Affect Activity of Hedgehogs (Erinaceus europaeus) during the Hibernation Period." Animals 10, no. 8 (August 4, 2020): 1344. http://dx.doi.org/10.3390/ani10081344.

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West European hedgehogs (Erinaceus europaeus) are likely to encounter unusual ecological features in urban habitats, such as anthropogenic food sources and artificial refugia. Quantifying how these affect hedgehog behaviour is vital for informing conservation guidelines for householders. We monitored hedgehog presence/absence in gardens in the town of Reading, UK, over the winter of 2017–2018 using a volunteer-based footprint tunnel survey, and collected data on garden characteristics, supplementary feeding (SF) habits, and local environmental conditions. Over a 20-week survey period, hedgehog presence was lowest between January and March. Occupancy analysis indicated that SF significantly affected hedgehog presence/absence before, during, and after hibernation. The number of nesting opportunities available in gardens, average temperatures, and daylength were also supported as important factors at different stages. In particular, our results suggest that SF could act to increase levels of activity during the winter when hedgehogs should be hibernating. Stimulating increased activity at this sensitive time could push hedgehogs into a net energy deficit or, conversely, help some individuals survive which might not otherwise do so. Therefore, further research is necessary to determine whether patterns of feeding by householders have a positive or negative effect on hedgehog populations during the hibernation period.
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Sarchese, Vittorio, Andrea Palombieri, Ilaria Prandi, Serena Robetto, Luigi Bertolotti, Maria Teresa Capucchio, Riccardo Orusa, et al. "Molecular Surveillance for Bocaparvoviruses and Bufaviruses in the European Hedgehog (Erinaceus europaeus)." Microorganisms 12, no. 1 (January 17, 2024): 189. http://dx.doi.org/10.3390/microorganisms12010189.

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The presence of bocaparvoviruses (BoVs) and bufaviruses (BuVs) in the European hedgehog (Erinaceus europaeus) was investigated by screening duodenal and liver samples collected from 183 carcasses, delivered to wildlife rescue centers located in northwestern Italy. BoV DNA was detected in 15 animals (8.2%), with prevalences of 7.1% (13/183) and 2.7% (5/183) in intestine and liver samples, respectively. Upon the sequence analyses of the NS1 gene, two highly divergent BoVs (65.5–67.8% nt identities) were identified. Fourteen strains showed the highest identity (98.3–99.4% nt) to the hedgehog BoV strains recently detected in China in Amur hedgehogs (Erinaceus amurensis), whilst four strains were genetically related (98.9–99.4% nt identities) to the porcine BoVs identified in pigs and classified in the species Bocaparvovirus ungulate 4, which included related viruses also found in rats, minks, shrews, and mice. BuV DNA was detected in the duodenal samples of two hedgehogs, with a prevalence rate of 1.1%. The nearly full-length genome of two BuV strains, Hedgehog/331DU-2022/ITA and Hedgehog/1278DU/2019/ITA, was reconstructed. Upon phylogenetic analysis based on the NS and VP aa sequences, the Italian hedgehog BuVs tightly clustered with the BuVs recently identified in the Chinese Amur hedgehogs, within a potential novel candidate species of the genus Protoparvovirus.
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Jones, C., G. Norbury, and T. Bell. "Impacts of introduced European hedgehogs on endemic skinks and weta in tussock grassland." Wildlife Research 40, no. 1 (2013): 36. http://dx.doi.org/10.1071/wr12164.

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Context Control of introduced pest species is based on the premise that there is a relationship between pest abundance and impact, but this relationship is rarely defined. Aim We investigated the impacts of introduced European hedgehogs (Erinaceus europaeus) on two species of small endemic skink (Oligosoma spp.) and flightless, nocturnal endemic orthopteran ground weta (Hemiandrus spp.), using an enclosure-based experimental manipulation of hedgehog density in tussock grasslands in the South Island of New Zealand. Methods We used capture–mark–recapture methods to estimate the densities of skinks before and after exposure to a range of hedgehog densities over a 3-month period and also compared changes in indices of abundance of skink demographic groups and ground weta. Key results Faecal analysis confirmed that hedgehogs consumed skinks and invertebrates in the enclosures. The proportional change between capture sessions in numbers of captured juvenile McCann’s skinks (O. maccanni) declined with increasing hedgehog density. Similarly, the proportional change in the numbers of ground weta encountered in pitfall traps showed a highly significant negative relationship with increasing hedgehog density. Total species abundances and numbers in other demographic skink groups did not change significantly in relation to hedgehog density. For overall skink abundance estimates, there was an apparent trend suggesting that changes in abundance were more negative with increasing hedgehog density, but this did not reach statistical significance for either skink species. Conclusions Our results confirmed that hedgehogs are important predators of small native fauna, but suggested that highly abundant prey populations may be buffered against significant impacts. Implications Less abundant prey and some demographic groups within populations, however, may be at significant risk from hedgehog predation.
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Dissertations / Theses on the topic "Hedgehog"

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Swift, Nathan Butler IV. "HEDGEMON: A HEDGEHOG-INSPIRED HELMET LINER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459380535.

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Jovanovic, Biljana. "The role of Hedgehog acyltransferase in Sonic hedgehog signalling." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/14486.

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Protein acyltransferases (PATs), a group of enzymes catalysing fatty acylation of a variety of proteins, play an important role in protein sorting and signalling in the cell. In the Hedgehog (Hh) signalling pathway the PAT Hedgehog acyltransferase (Hhat) is responsible for addition of a palmitic acid to the N-terminal cysteine of Hh proteins. This modification is necessary for proper packaging and release of Hh ligands from the signalling cell and for transmitting a potent signal to the receiving cell. Hh signalling regulates cell growth and differentiation. Improper activation of the Hh signalling pathway in cancer arises either through an upregulation of ligand-dependent autocrine or paracrine signalling, or oncogenic mutations in the signal receiving cell. To date, drug therapies targeting the pathway in cancer have been directed at pathway regulators downstream of ligand binding. In this thesis, I investigate the potential of Hhat as a therapeutic target in lung cancer cell lines that express Sonic hedgehog (Shh). Studies of lung cancer cell lines A549, H209 and H82 treated with Shh pathway inhibitors showed no autocrine dependence on Shh signalling. Nonetheless, A549 cells were capable of inducing a Shh signal response in C3H10T½ cells in co-culture in a juxtacrine/paracrine fashion indicating that Shh in lung cancer cells may be involved in juxtacrine/paracrine signalling to the surrounding stroma. This effect was effectively attenuated by siRNA-mediated Hhat knock-down confirming the potential of Hhat as therapeutic target in cancer. I further provide a membrane topology model of Hhat which will aid in understanding the molecular mechanism of this enzyme. Membrane topology determination resulted in a topology model where Hhat consists of 11 transmembrane regions with the signal peptide preserved in the mature protein. Surprisingly, the suggested catalytic site, a conserved His, is localised in a transmembrane region near the cytosol away from the site of Hh palmitoylation which occurs in the lumen of the endoplasmic reticulum. Taken together, my results provide a firm basis for further investigation of the mechanism of action of Hhat and its role as a potential drug target in multiple human cancers.
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Lau, C. I. "Hedgehog signalling in haematopoiesis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1428443/.

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The Hedgehog (Hh) family proteins and their signalling pathway are key mediators of, and important in, many mammalian developmental processes. Malfunction of the Hh signalling pathway contributes to developmental disorders and birth defects. This project aims to investigate the role of the Hh signalling pathway in murine haematopoiesis. In our study, we found that Dhh plays a negative regulatory role in normal erythropoiesis and under stress conditions. However, it is not required for regulating erythropoiesis in the fetal liver during embryo development. In contrast, analysis of conditional deletion of Smo in haematopoietic cells revealed that Smo controls early haematopoietic differentiation in the fetal liver but is dispensable for regulating haematopoiesis in adult bone marrow and spleen. Furthermore, pervious studies have demonstrated that Hh signalling is involved in T-cell development throughout maturation. We tested the hypothesis that Foxa2, a downstream target gene of Hh during pre-TCR signalling, is also required for late T-cell development and activation. Analysis of mice conditionally Foxa2-deficient in mature T-cells revealed that Foxa2 is important in the process of maturation in late thymocyte development. In addition, Foxa2 is also involved in regulation of T-cell activation, and the differentiation of T helper cells. Gene expression experiments confirmed that Foxa2 is also a Hh target gene in the thymus. Taken together, our findings revealed that the Hh signalling pathway and its target genes play critical roles in haematopoiesis during embryogenesis and in adult mice.
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Siegwarth, Mark D. "The Arizona Hedgehog Project." University of Arizona (Tucson, AZ), 2014. http://hdl.handle.net/10150/622042.

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An intergovernmental agreement was signed on August 26, 2008 between the Arizona Department of Transportation (ADOT) and Boyce Thompson Arboretum (BTA) for the Arizona Hedgehog Project. The project was to transplant individuals of the Arizona hedgehog cactus (Echinocereus triglochidiatus var. arizonicus or AHC) from the US Highway 60 ADOT project area to Boyce Thompson Arboretum and conduct a 5-year research study on the AHC to learn more about how to increase success of future salvage efforts. In addition, the project included the development of interpretive/educational materials including printed materials and signage to explain the project to the more than 75,000 annual visitors who visit the Arboretum. The transplant sites at the Arboretum offer an excellent opportunity for informing the general public, adults and children alike, about the importance of conserving the Arizona hedgehog and other endangered species. As stated above, the Arizona Hedgehog project is comprised of two distinct but overlapping parts: the physical movement of the plants to Boyce Thompson Arboretum and an extended study of transplantation success. In brief, we first evaluated the plants in situ at the US Highway 60 ADOT project location, then removed the plants and transported them to BTA. Although there were to be two different plantings, fall and spring, delays and fewer than the expected number of AHC needing salvage mandated that all plantings be done in the fall. Finally, we evaluated the success of the transplants over a 5-year period. This was essentially an observational study. Germplasm was shared with other researchers, which will provide additional information.
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Chang, Shu-Chun. "The role of hedgehog acyltransferase & heparan sulphate proteoglycans in human sonic hedgehog signalling." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6837.

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Hedgehog proteins (Hh) are morphogens and major mediators in many developmental processes. Hh signalling is significant for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancers. Hh proteins require dual lipidation and Heparan Sulfate Proteoglycans (HSPGs) for their proper distribution and signalling activity. My first aim was to study the role of HSPGs in human (h) Sonic Hedgehog (Shh) signalling and clarify the biological function of hShh/HSPGs complexes in hShh signalling, by investigating the interaction between human hShh and HSPGs. I used DNA mutagenesis and heparin affinity chromatography to determine key residues in hShh involved in heparin binding (K37/38 and K178). The activity of these mutants was tested by detecting induced Alkaline Phosphatase activity in C3H10T1/2 cells and hShh-inducible gene expression in PANC1 human pancreatic carcinoma cells. I examined the biological function of mutated hShhs (K37/38S, K178S and K37/38/178S) that cannot interact with heparin efficiently and showed that they had reduced signalling activity compared to wild type hShh and a control mutation (K74S). Also, I showed that mutant hShh proteins mediate reduced proliferation and invasion of PANC1 cells following hShh RNAi knockdown (KD), and this correlated with reduced Shh multimeric complex formation. Structurally, Shh proteins are unusual in being dually lipid-modified to be fully active. During the post-translational modifications of Shh, N-terminal palmitoylation is facilitated by the product (Hhat) of the hedgehog acyltransferase gene. I have carried out a thorough analysis of Hhat in PANC1 cells. First, I characterised an antibody prepared in the lab to hHhat. I confirmed the specificity of the antibody by immunoblotting using a self-constructed hHhat-EGFP clone, and a control mGup1-EGFP clone. By subcellular fractionation and Western blotting I found Hhat to be a membrane protein. In addition, I used the hHhat antibody to determine the intracellular localisation of hHhat in PANC1 cells by confocal microscopy and showed that hHhat localised in ER mainly but not in Golgi apparatus. I confirmed this using the hHhat-EGFP clone for fluorescence microscopy in transfected cells. To illuminate the biological function of palmitoylation of hShh in production of active hShh and in the formation of hShh multimeric complex I optimised hHhat RNAi knockdown (KD) in PANC1 cells and confirmed this by a cell-based palmitoylation assay. Using semi-quantitative RT-PCR and immunoblot analyses, I showed that hHhat KD caused decreased signalling through the Shh pathway due to reduced production of active hShh. In addition, I investigated the effect of the addition of palmitate to hShh on its association with cells by comparing hHhat KD cells with control cells. Immunoblotting suggests that palmitoylation of Shh improves its ability to associate to cell membranes. Using hHhat KD, gel filtration of high molecular weight complexes of hShh and immunoblotting of hShh I characterised the role of palmitoylation of hShh in multimeric complex formation. Lastly, I investigated the effect of hHhat KD on PANC1 proliferation and invasion, showing that it represses PANC1 proliferation and invasion. These studies provide a firm basis for understanding the functional roles of hShh palmitoylation and its interactions with HSPGs, and provide proof-of-principle for targeting these aspects of hShh biology in tumour cell therapeutics, specifically in the pancreatic carcinoma context.
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Haines, Nicola. "Mutational analysis of hedgehog signalling." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365823.

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Gorka, Oliver. "Hedgehog-Signale in rheumatoider Arthritis." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-43288.

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Lau, Janet. "Hedgehog signaling in the pancreas epithelium." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398879.

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Koziel, Lydia. "Indian hedgehog signaling during endochondral ossification." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2005/68/index.html.

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Tukachinsky, Hanna. "Mechanistic Studies of Vertebrate Hedgehog Signaling." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10691.

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Metazoans use Hedgehog signaling to direct many stages of embryonic development, and deregulation of this pathway is implicated in many types of cancer. I investigated several steps of Hedgehog pathway transduction that were poorly understood in mechanistic terms. The mature Hedgehog ligand is produced by a self-proteolysis reaction that covalently attaches a cholesterol molecule to the signaling half of the protein. I showed that the catalytic cysteine forms a disulfide bridge that is essential for the folding and function of the C-terminal tail of Hedgehog, and identified two protein disulfide isomerases that remodel this bridge to free the catalytic thiol group after folding is complete. Using pulse chase assays to follow Hedgehog processing, I demonstrated that the self-proteolysis reaction takes place in the endoplasmic reticulum, that the cleaved C-terminal tail of Hedgehog is degraded before moving to the Golgi, and that Hedgehog mutants defective in processing get degraded in their entirety by the same route. Lipidated Hedgehog ligand requires the transmembrane protein Dispatched for secretion. I devised a system to test Dispatched function in cultured cells, and showed that some inactive Dispatched mutants fail to bind Hedgehog, while others bind more tightly than the wild type protein. Scube2 was implicated as a Hedgehog pathway component in zebrafish genetic studies. I showed that Scube2 is a secreted protein that binds Hedgehog via its cholesterol adduct and solubilizes it in aqueous media. Dispatched and Scube2 bind Hedgehog on opposing faces, and they function synergistically to release it from the membrane. Vertebrate Hedgehog signaling relies on intraflagellar transport through an antenna-like organelle called the primary cilium. The Hedgehog receptor Patched and transducer protein Smoothened localize to primary cilia in a mutually exclusive pattern, depending on Hedgehog ligand presence. I showed that cytoplasmic components of the pathway Suppressor of Fused (SuFu, a pathway inhibitor) and Glioma-associated oncogene transcription factors (the Gli family, the effectors of the pathway) localize to primary cilia and accumulate there when Smoothened is activated. SuFu and Gli form a complex that dissociates when the pathway is turned on, and this dissociation depends on trafficking through the cilium.
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Books on the topic "Hedgehog"

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Hedgehog. London: Raintree, 2014.

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Rizzatti, Lorella. Hedgehog. Racine, Wis: Western Pub. Co., 1993.

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Hedgehog. New York, New York: Bearport Publishing, 2016.

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Michael, Leach. Hedgehog. New York: Rosen Pub. Group's PowerKids Press, 2009.

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Bian, Ji Shi. Hedgehog. China: Zhongguoshaoer (China Children's Press), 1999.

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Matzke, Ann H. Hedgehog. North Mankato, Minnesota]: Rourke Publishing, LLC, 2016.

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Jane, Durrant, ed. The natural hedgehog. London: Bounty Books, 2005.

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Dodd, Lynley. Hedgehog howdedo. Wellington, N.Z: Mallinson Rendel, 2000.

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Li, Xiaochun, ed. Hedgehog Signaling. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1701-4.

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D, H. The hedgehog. New York: Published for James Laughlin by New Directions Pub. Corp., 1988.

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Book chapters on the topic "Hedgehog"

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Robert, Jacques. "Hedgehog Pathway." In Textbook of Cell Signalling in Cancer, 109–15. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_9.

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Wicking, Carol. "Hedgehog Signaling." In Encyclopedia of Cancer, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_2602-2.

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Wicking, Carol. "Hedgehog Signaling." In Encyclopedia of Cancer, 2002–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_2602.

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Wicking, Carol. "Hedgehog Signaling." In Encyclopedia of Cancer, 1637–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2602.

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Kinnebrew, Maia, Kristen A. Johnson, Arun Radhakrishnan, and Rajat Rohatgi. "Measuring and Manipulating Membrane Cholesterol for the Study of Hedgehog Signaling." In Hedgehog Signaling, 73–87. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_7.

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Constable, Sandii, Kevin White, Bandarigoda Nipunika Somatilaka, and Saikat Mukhopadhyay. "Studying Hedgehog Signaling During Mouse Neural Tube Development." In Hedgehog Signaling, 59–71. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_6.

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Walker, Madison F., and Benjamin R. Myers. "Rapid, Direct SMOOTHENED Activity Assays in Live Cells Using cAMP-Based Conformational Sensors." In Hedgehog Signaling, 175–84. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_15.

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Hu, Ao, Meng Zhou, and Bao-Liang Song. "Analysis of Protein Cholesterylation by Biorthogonal Labeling." In Hedgehog Signaling, 27–36. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_3.

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Liu, Heng, and Cheng Zhang. "Measuring Smoothened (SMO)-Mediated Activation of the Gi Protein." In Hedgehog Signaling, 205–12. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_18.

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Wilson, Alexandra N., Baozhi Chen, Xin Liu, Jonathan M. Kurie, and James Kim. "A Method for Orthotopic Transplantation of Lung Cancer in Mice." In Hedgehog Signaling, 231–42. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1701-4_20.

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Conference papers on the topic "Hedgehog"

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Keswani, Vaibhav. "Hedgehog." In SIGGRAPH '19: Special Interest Group on Computer Graphics and Interactive Techniques Conference. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3302502.3314055.

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Keswani, Vaibhav, Jeanne Laureau, Colombine Majou, Morgane Mattard, Kaisa Pirttinen, and Jong-ha Yoon. "Hedgehog." In SA '19: SIGGRAPH Asia 2019. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3354919.3365174.

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Yin, Zhigang, Mohan Liyanage, Agustin Zuniga, Petteri Nurmi, and Huber Flores. "Hedgehog." In HotMobile '23: The 24th International Workshop on Mobile Computing Systems and Applications. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3572864.3580336.

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Witczyńska, Anna, Zuzanna Bukowska, Anna Wilczyńska, Michał Wójcik, and Łukasz Adaszek. "Wobbly Hedgehog Syndrome in African pygmy and European hedgehogs." In 1st International PhD Student’s Conference at the University of Life Sciences in Lublin, Poland: ENVIRONMENT – PLANT – ANIMAL – PRODUCT. Publishing House of The University of Life Sciences in Lublin, 2022. http://dx.doi.org/10.24326/icdsupl1.a033.

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Mgallad, Ali. "Leave the Hedgehog Alone! The Problem of Privacy in Paul Muldoon's Hedgehog." In 3rd International Conference on Language and Education. Cihan University-Erbil, 2023. http://dx.doi.org/10.24086/iclangedu2023/paper.942.

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Abstract:
Paul Muldoon is an outstanding Irish poet. One of his poetry's characteristics can be coined as the 'intricate spontaneity,' which does the most that it does, inspires. This paper deals with the problem of privacy in his poem the Hedgehog. Privacy is an essential right that everyone must have. Its importance is huge as it relates to such areas as identity, sovereignty... etc. The paper is an attempt to follow the brush touches by which the poet draws the object of his painting, the hedgehog. It aims at observing the animal closely both externally as well as internally. In respect to the external part, the symbolism the poet makes use of through this object of painting is impressive and urges upon examining. As for the internal part, the poem is to be mystically considered for a better understanding of its purport concerning the concept of privacy. The paper setting benefits of Imagism tools to assess the poem properly.
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Xie, Jingwu, Eric Qipeng Fan, Chelsea Schelgel, Xiaoli Zhang, Massound Garrisson, and Miao He. "Abstract 708: A novel hedgehog signaling inhibitor blocks hedgehog-mediated carcinogenesis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-708.

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Kanazawa, I. "Hedgehog-like solitons in glasses." In The 8th tohwa university international symposium on slow dynamics in complex systems. AIP, 1999. http://dx.doi.org/10.1063/1.58546.

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Jovanovic, Biljana, Shu-Chun Chang, Mirella Koleva, and Anthony I. Magee. "Abstract 3956: Hedgehog acyltransferase: A key player in Sonic hedgehog signalling in cancer cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3956.

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Kugler, Matthias C., Li Liu, Gregory Chen, Cynthia A. Loomis, Willliam N. Rom, and John S. Munger. "Hedgehog Signaling In Adult Lung Fibroblasts." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5528.

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Miller, Joseph, Juwina Wijaya, Giles W. Robinson, Vikas Daggubati, David R. Raleigh, and John Schuetz. "ABCA13 Regulation of the Hedgehog pathway." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.051.980920.

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Reports on the topic "Hedgehog"

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Bushman, Wade. Sonic Hedgehog Signaling Promotes Tumor Growth. Fort Belvoir, VA: Defense Technical Information Center, February 2005. http://dx.doi.org/10.21236/ada446387.

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Bushman, Wade. Sonic Hedgehog Signaling Promotes Tumor Growth. Fort Belvoir, VA: Defense Technical Information Center, February 2006. http://dx.doi.org/10.21236/ada452504.

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Bushman, Wade. Sonic Hedgehog Signaling Promotes Tumor Growth. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada469894.

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Lewis, Michael T. Hedgehog Signal Transduction Inhibitors in Breast Cancer Treatment and Prevention. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada398338.

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Lewis, Michael T. Hedgehog Signal Transduction Inhibitors in Breast Cancer Treatment and Prevention. Fort Belvoir, VA: Defense Technical Information Center, July 2004. http://dx.doi.org/10.21236/ada429377.

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Lewis, Michael T. Hedgehog Signal Transduction Inhibitors in Breast Cancer Treatment and Prevention. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada410868.

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Lewis, Michael T. Hedgehog Signal Transduction Inhibitors in Breast Cancer Treatment and Prevention. Fort Belvoir, VA: Defense Technical Information Center, August 2003. http://dx.doi.org/10.21236/ada421788.

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Xie, Jingwu. The Role of the Sonic Hedgehog Pathway for Prostate Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada488163.

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Xie, Jingwu. The Role of the Sonic Hedgehog Pathway for Prostate Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, February 2005. http://dx.doi.org/10.21236/ada447632.

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Xie, Jingwu. The Role of the Sonic Hedgehog Pathway for Prostate Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, February 2006. http://dx.doi.org/10.21236/ada452305.

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