Journal articles on the topic 'HECW1'
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Erdman, Vera V., Denis D. Karimov, Ilsia A. Tuktarova, Yanina R. Timasheva, Timur R. Nasibullin, and Gulnaz F. Korytina. "Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity." International Journal of Molecular Sciences 23, no. 21 (November 4, 2022): 13492. http://dx.doi.org/10.3390/ijms232113492.
Full textHaouari, Shanez, Christian Robert Andres, Debora Lanznaster, Sylviane Marouillat, Céline Brulard, Audrey Dangoumau, Devina Ung, et al. "Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1." International Journal of Molecular Sciences 24, no. 2 (January 9, 2023): 1268. http://dx.doi.org/10.3390/ijms24021268.
Full textLiu, Jia, Su Dong, Lian Li, Heather Wang, Jing Zhao, and Yutong Zhao. "The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system." Cellular Signalling 58 (June 2019): 91–98. http://dx.doi.org/10.1016/j.cellsig.2019.03.005.
Full textLiu, Jia, Su Dong, Heather Wang, Lian Li, Qinmao Ye, Yanhui Li, Jiaxing Miao, Sissy Jhiang, Jing Zhao, and Yutong Zhao. "Two distinct E3 ligases, SCF FBXL19 and HECW1, degrade thyroid transcription factor 1 in normal thyroid epithelial and follicular thyroid carcinoma cells, respectively." FASEB Journal 33, no. 9 (June 25, 2019): 10538–50. http://dx.doi.org/10.1096/fj.201900415r.
Full textChen, Yumay, Daniel J. Riley, Lei Zheng, Phang-Lang Chen, and Wen-Hwa Lee. "Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation." Journal of Biological Chemistry 277, no. 51 (October 16, 2002): 49408–16. http://dx.doi.org/10.1074/jbc.m207069200.
Full textWu, Guikai, Randy Wei, Eric Cheng, Bryan Ngo, and Wen-Hwa Lee. "Hec1 Contributes to Mitotic Centrosomal Microtubule Growth for Proper Spindle Assembly through Interaction with Hice1." Molecular Biology of the Cell 20, no. 22 (November 15, 2009): 4686–95. http://dx.doi.org/10.1091/mbc.e08-11-1123.
Full textSundin, Lynsie J. R., Geoffrey J. Guimaraes, and Jennifer G. DeLuca. "The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore–microtubule attachment in mitosis." Molecular Biology of the Cell 22, no. 6 (March 15, 2011): 759–68. http://dx.doi.org/10.1091/mbc.e10-08-0671.
Full textWei, Randy, Bryan Ngo, Guikai Wu, and Wen-Hwa Lee. "Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint." Molecular Biology of the Cell 22, no. 19 (October 2011): 3584–94. http://dx.doi.org/10.1091/mbc.e11-01-0012.
Full textTooley, John G., Stephanie A. Miller, and P. Todd Stukenberg. "The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement." Molecular Biology of the Cell 22, no. 8 (April 15, 2011): 1217–26. http://dx.doi.org/10.1091/mbc.e10-07-0626.
Full textDeLuca, Jennifer G., Yimin Dong, Polla Hergert, Joshua Strauss, Jennifer M. Hickey, E. D. Salmon, and Bruce F. McEwen. "Hec1 and Nuf2 Are Core Components of the Kinetochore Outer Plate Essential for Organizing Microtubule Attachment Sites." Molecular Biology of the Cell 16, no. 2 (February 2005): 519–31. http://dx.doi.org/10.1091/mbc.e04-09-0852.
Full textWimbish, Robert T., Keith F. DeLuca, Jeanne E. Mick, Jack Himes, Ignacio Jiménez-Sánchez, A. Arockia Jeyaprakash, and Jennifer G. DeLuca. "The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment." Molecular Biology of the Cell 31, no. 14 (July 1, 2020): 1453–73. http://dx.doi.org/10.1091/mbc.e20-05-0286.
Full textDeLuca, Keith F., Amanda Meppelink, Amanda J. Broad, Jeanne E. Mick, Olve B. Peersen, Sibel Pektas, Susanne M. A. Lens, and Jennifer G. DeLuca. "Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics." Journal of Cell Biology 217, no. 1 (November 29, 2017): 163–77. http://dx.doi.org/10.1083/jcb.201707160.
Full textZaytsev, Anatoly V., Lynsie J. R. Sundin, Keith F. DeLuca, Ekaterina L. Grishchuk, and Jennifer G. DeLuca. "Accurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions." Journal of Cell Biology 206, no. 1 (June 30, 2014): 45–59. http://dx.doi.org/10.1083/jcb.201312107.
Full textNijenhuis, Wilco, Eleonore von Castelmur, Dene Littler, Valeria De Marco, Eelco Tromer, Mathijs Vleugel, Maria H. J. van Osch, Berend Snel, Anastassis Perrakis, and Geert J. P. L. Kops. "A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B." Journal of Cell Biology 201, no. 2 (April 8, 2013): 217–31. http://dx.doi.org/10.1083/jcb.201210033.
Full textYanagishita, Tomoe, Takuya Hirade, Keiko Shimojima Yamamoto, Makoto Funatsuka, Yusaku Miyamoto, Makiko Maeda, Kumiko Yanagi, et al. "HECW2 ‐related disorder in four Japanese patients." American Journal of Medical Genetics Part A 185, no. 10 (May 28, 2021): 2895–902. http://dx.doi.org/10.1002/ajmg.a.62363.
Full textMikami, Yoshikazu, Tetsuya Hori, Hiroshi Kimura, and Tatsuo Fukagawa. "The Functional Region of CENP-H Interacts with the Nuf2 Complex That Localizes to Centromere during Mitosis." Molecular and Cellular Biology 25, no. 5 (March 1, 2005): 1958–70. http://dx.doi.org/10.1128/mcb.25.5.1958-1970.2005.
Full textLi, L., Y. Zhou, G. F. Wang, S. C. Liao, Y. B. Ke, W. Wu, X. H. Li, R. L. Zhang, and Y. C. Fu. "Anaphase-promoting complex/cyclosome controls HEC1 stability." Cell Proliferation 44, no. 1 (December 29, 2010): 1–9. http://dx.doi.org/10.1111/j.1365-2184.2010.00712.x.
Full textKrishnamoorthy, Vidhya, Richa Khanna, and Veena K. Parnaik. "E3 ubiquitin ligase HECW2 targets PCNA and lamin B1." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865, no. 8 (August 2018): 1088–104. http://dx.doi.org/10.1016/j.bbamcr.2018.05.008.
Full textZaytsev, Anatoly V., Jeanne E. Mick, Evgeny Maslennikov, Boris Nikashin, Jennifer G. DeLuca, and Ekaterina L. Grishchuk. "Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity." Molecular Biology of the Cell 26, no. 10 (May 15, 2015): 1829–44. http://dx.doi.org/10.1091/mbc.e14-11-1539.
Full textTan, Yi, Chengling Zhang, Ying Zhang, Xueshan Dai, Qinghua Wei, Jiahui Wei, Pingli Xu, and Yi Chen. "Combination of ferulic acid, ligustrazine and tetrahydropalmatine inhibits invasion and metastasis through MMP/TIMP signaling in endometriosis." PeerJ 9 (June 28, 2021): e11664. http://dx.doi.org/10.7717/peerj.11664.
Full textWang, Zan-Ying, Wen-Qiong Liu, Si’e Wang, and Zeng-Tao Wei. "Fisetin induces G2/M phase cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation in human endometrial cancer cells." Bangladesh Journal of Pharmacology 10, no. 2 (April 3, 2015): 279. http://dx.doi.org/10.3329/bjp.v10i2.21945.
Full textKuhn, Jonathan, and Sophie Dumont. "Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner." Journal of Cell Biology 218, no. 11 (September 6, 2019): 3583–96. http://dx.doi.org/10.1083/jcb.201902105.
Full textGurzov, E. N., and M. Izquierdo. "RNA interference against Hec1 inhibits tumor growth in vivo." Gene Therapy 13, no. 1 (August 25, 2005): 1–7. http://dx.doi.org/10.1038/sj.gt.3302595.
Full textZhu, Z. B., B. Lu, M. Numnum, S. K. Makhija, M. Wang, P. Reynolds, G. P. Siegal, and D. T. Curiel. "227 RNA interference against Hec1 targets malignant mesothelioma (MM)." Lung Cancer 54 (October 2006): S55. http://dx.doi.org/10.1016/s0169-5002(07)70303-3.
Full textZihala, David, Tereza Sevcikova, Michal Simicek, Tereza Popkova, Hana Plonkova, Lucie Broskevicova, Jan Vrana, et al. "Identification of Molecular Mechanisms Responsible for the Development of Extramedullary Disease in Myeloma and Potential Novel Therapeutic Targets Using Transcriptomic and Exome Profiling." Blood 136, Supplement 1 (November 5, 2020): 16–17. http://dx.doi.org/10.1182/blood-2020-142300.
Full textLee, Sanghwa, Ling Zhu, and Enamul Huq. "An autoregulatory negative feedback loop controls thermomorphogenesis in Arabidopsis." PLOS Genetics 17, no. 6 (June 1, 2021): e1009595. http://dx.doi.org/10.1371/journal.pgen.1009595.
Full textIemura, Kenji, Yujiro Yoshizaki, Kinue Kuniyasu, and Kozo Tanaka. "Attenuated Chromosome Oscillation as a Cause of Chromosomal Instability in Cancer Cells." Cancers 13, no. 18 (September 9, 2021): 4531. http://dx.doi.org/10.3390/cancers13184531.
Full textMehta, Ajay, Samantha Seymour, William Wilson, and Christina Peroutka. "eP188: Novel HECW2 variant presenting with tachypnea and multisystemic congenital malformations." Genetics in Medicine 24, no. 3 (March 2022): S116. http://dx.doi.org/10.1016/j.gim.2022.01.224.
Full textKrishnamoorthy, Vidhya, Richa Khanna, and Veena K. Parnaik. "E3 ubiquitin ligase HECW2 mediates the proteasomal degradation of HP1 isoforms." Biochemical and Biophysical Research Communications 503, no. 4 (September 2018): 2478–84. http://dx.doi.org/10.1016/j.bbrc.2018.07.003.
Full textDiaz-Rodriguez, Elena. "Targeting the Kinetochore in Cancer Therapy: The Ndc80/Hec1 Complex." Current Drug Therapy 5, no. 1 (February 1, 2010): 29–35. http://dx.doi.org/10.2174/1574885511005010029.
Full textHua, Shasha, Zhikai Wang, Kai Jiang, Yuejia Huang, Tarsha Ward, Lingli Zhao, Zhen Dou, and Xuebiao Yao. "CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment." Journal of Biological Chemistry 286, no. 2 (November 5, 2010): 1627–38. http://dx.doi.org/10.1074/jbc.m110.174946.
Full textDeLuca, Jennifer G., Walter E. Gall, Claudio Ciferri, Daniela Cimini, Andrea Musacchio, and E. D. Salmon. "Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1." Cell 127, no. 5 (December 2006): 969–82. http://dx.doi.org/10.1016/j.cell.2006.09.047.
Full textVincent, Soriano. "Hepatitis B Virus Infection Despite Receiving Lamivudine in One HIV-Infected Person." HIV Clinical Trials 4, no. 1 (February 2003): 77–78. http://dx.doi.org/10.1310/6dmu-hec1-eax7-rlun.
Full textWei, Xiaomou, Chunhai Gao, Jia Luo, Wei Zhang, Shuhao Qi, Weijun Liang, and Shengming Dai. "Hec1 inhibition alters spindle morphology and chromosome alignment in porcine oocytes." Molecular Biology Reports 41, no. 8 (April 22, 2014): 5089–95. http://dx.doi.org/10.1007/s11033-014-3374-4.
Full textWei, Ronnie R., Jawdat Al-Bassam, and Stephen C. Harrison. "The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment." Nature Structural & Molecular Biology 14, no. 1 (December 31, 2006): 54–59. http://dx.doi.org/10.1038/nsmb1186.
Full textDeLuca, K. F., S. M. A. Lens, and J. G. DeLuca. "Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis." Journal of Cell Science 124, no. 4 (January 25, 2011): 622–34. http://dx.doi.org/10.1242/jcs.072629.
Full textDiaz-Rodriguez, E., R. Sotillo, J. M. Schvartzman, and R. Benezra. "Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo." Proceedings of the National Academy of Sciences 105, no. 43 (October 21, 2008): 16719–24. http://dx.doi.org/10.1073/pnas.0803504105.
Full textQu, Ying, Jianfang Li, Qu Cai, and Bingya Liu. "Hec1/Ndc80 is overexpressed in human gastric cancer and regulates cell growth." Journal of Gastroenterology 49, no. 3 (April 17, 2013): 408–18. http://dx.doi.org/10.1007/s00535-013-0809-y.
Full textMattiuzzo, Marta, Giulia Vargiu, Pierangela Totta, Mario Fiore, Claudio Ciferri, Andrea Musacchio, and Francesca Degrassi. "Abnormal Kinetochore-Generated Pulling Forces from Expressing a N-Terminally Modified Hec1." PLoS ONE 6, no. 1 (January 28, 2011): e16307. http://dx.doi.org/10.1371/journal.pone.0016307.
Full textNakamura, Haruhiko, Mitsugu Uematsu, Yurika Numata-Uematsu, Yu Abe, Wakaba Endo, Atsuo Kikuchi, Yusuke Takezawa, et al. "Rett-like features and cortical visual impairment in a Japanese patient with HECW2 mutation." Brain and Development 40, no. 5 (May 2018): 410–14. http://dx.doi.org/10.1016/j.braindev.2017.12.015.
Full textOrticello, M., M. Fiore, P. Totta, M. Desideri, M. Barisic, D. Passeri, J. Lenzi, et al. "N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore–microtubule dynamics." Oncogene 34, no. 25 (August 18, 2014): 3325–35. http://dx.doi.org/10.1038/onc.2014.265.
Full textZhao, Gangyin, Yubao Cheng, Ping Gui, Meiying Cui, Wei Liu, Wenwen Wang, Xueying Wang, et al. "Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule–kinetochore attachment." Journal of Biological Chemistry 294, no. 2 (November 8, 2018): 576–92. http://dx.doi.org/10.1074/jbc.ra118.003844.
Full textMartin-Lluesma, S. "Role of Hec1 in Spindle Checkpoint Signaling and Kinetochore Recruitment of Mad1/Mad2." Science 297, no. 5590 (September 27, 2002): 2267–70. http://dx.doi.org/10.1126/science.1075596.
Full textChang, Howard C., Jennifer Paek, and Dennis H. Kim. "Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour." Nature 480, no. 7378 (November 16, 2011): 525–29. http://dx.doi.org/10.1038/nature10643.
Full textLong, Alexandra F., Dylan B. Udy, and Sophie Dumont. "Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules." Current Biology 27, no. 11 (June 2017): 1692–99. http://dx.doi.org/10.1016/j.cub.2017.04.058.
Full textHuang, Lynn YL, Chia-chi Chang, Ying-Shuan Lee, Jiann-Jyh Huang, Shih-Hsien Chuang, Jia-Ming Chang, Kuo-Jang Kao, et al. "Inhibition of Hec1 as a novel approach for treatment of primary liver cancer." Cancer Chemotherapy and Pharmacology 74, no. 3 (July 20, 2014): 511–20. http://dx.doi.org/10.1007/s00280-014-2540-7.
Full textGuimaraes, Geoffrey J., Yimin Dong, Bruce F. McEwen, and Jennifer G. DeLuca. "Kinetochore-Microtubule Attachment Relies on the Disordered N-Terminal Tail Domain of Hec1." Current Biology 18, no. 22 (November 2008): 1778–84. http://dx.doi.org/10.1016/j.cub.2008.08.012.
Full textCiferri, Claudio, Jennifer De Luca, Silvia Monzani, Karin J. Ferrari, Dejan Ristic, Claire Wyman, Holger Stark, John Kilmartin, Edward D. Salmon, and Andrea Musacchio. "Architecture of the Human Ndc80-Hec1 Complex, a Critical Constituent of the Outer Kinetochore." Journal of Biological Chemistry 280, no. 32 (June 16, 2005): 29088–95. http://dx.doi.org/10.1074/jbc.m504070200.
Full textQiu, Xiao-Long, Guideng Li, Guikai Wu, Jiewen Zhu, Longen Zhou, Phang-Lang Chen, A. Richard Chamberlin, and Wen-Hwa Lee. "Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues." Journal of Medicinal Chemistry 52, no. 6 (March 26, 2009): 1757–67. http://dx.doi.org/10.1021/jm8015969.
Full textMo, Qing-qing, Ping-bo Chen, Xin Jin, Qian Chen, Lan Tang, Bei-bei Wang, Ke-zhen Li, et al. "Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel." Acta Pharmacologica Sinica 34, no. 4 (March 11, 2013): 541–48. http://dx.doi.org/10.1038/aps.2012.197.
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