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Journal articles on the topic 'Heart transplantate'

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Author: Grafiati

Published: 11 March 2023

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1

Honek, Tomáš, Jan Krejčí, Lenka Špinarová, Petr Hude, Petr Němec, Zdeněk Adam, Alžběta Sirotková, Víta Žampachová, and Jiří Vítovec. "Heart transplantation for cardiac light chain amyloidosis with subsequent autologous stem cell transplantation." Cor et Vasa 55, no. 5 (October 1, 2013): e468-e473. http://dx.doi.org/10.1016/j.crvasa.2012.11.015.

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2

Špinarová, Lenka. "Heart transplantation." Cor et Vasa 50, no. 3 (March 1, 2008): 133–38. http://dx.doi.org/10.33678/cor.2008.045.

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3

Špinarová, Lenka, Jindřich Špinar, and Jiří Vítovec. "The heart transplantation." Vnitřní lékařství 64, no. 9 (September 1, 2018): 860–66. http://dx.doi.org/10.36290/vnl.2018.118.

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4

Ozábalová, Eva, Jan Krejčí, Petr Hude, Julius Godava, Tomáš Honek, Lenka Špinarová, Petr Pavlík, Helena Bedáňová, and Petr Němec. "Heart transplantation and infection." Vnitřní lékařství 63, no. 7-8 (July 1, 2017): 535–39. http://dx.doi.org/10.36290/vnl.2017.109.

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5

Málek, Ivan. "Indications for heart transplantation." Cor et Vasa 50, no. 3 (March 1, 2008): 129–32. http://dx.doi.org/10.33678/cor.2008.044.

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6

Manuel Pêgo-Fernandes, Paulo. "Heart-lung transplantation: a necessity." Jornal Brasileiro de Pneumologia 46, no. 3 (May 2020): e20190273-e20190273. http://dx.doi.org/10.36416/1806-3756/e20190273.

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7

Horváth, Vladimír, Petr Němec, Jiří Ondrášek, Jiří Slavík, Petr Pokorný, Helena Bedáňová, and Marek Orban. "Heart transplantation after short-term mechanical circulatory support." Cor et Vasa 55, no. 4 (August 1, 2013): e320-e323. http://dx.doi.org/10.1016/j.crvasa.2013.05.002.

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8

Ošmerová, Marie, Petr Němec, and Jan Černý. "Pediatric heart transplantation: 17-year Brno experience." Cor et Vasa 55, no. 4 (August 1, 2013): e315-e319. http://dx.doi.org/10.1016/j.crvasa.2013.05.008.

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9

Špinarová, Lenka, Peter Lidinský, Petr Hude, Jan Krejčí, Hana Poloczková, Július Godava, and Jiří Vítovec. "Metabolic profile of patients after heart transplantation." Cor et Vasa 55, no. 4 (August 1, 2013): e324-e329. http://dx.doi.org/10.1016/j.crvasa.2013.06.010.

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10

Godava, Július, Jan Krejčí, Petr Hude, Eva Ozábalová, Tomáš Honek, Petr Němec, Michal Tichý, Marta Pažourková, and Lenka Špinarová. "Invasive aspergillosis following the heart transplantation - A case report." Cor et Vasa 58, no. 5 (October 1, 2016): e509-e512. http://dx.doi.org/10.1016/j.crvasa.2015.12.002.

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11

Cihlová, Milada, Hikmet Al-Hiti, Vojtěch Melenovský, Ivan Málek, and Josef Kautzner. "Treatment of severe pulmonary hypertension with sildenafil in a heart transplant candidate for advanced heart failure." Cor et Vasa 51, no. 4 (April 1, 2009): 279–81. http://dx.doi.org/10.33678/cor.2009.068.

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12

Pasnišinová, Silvia, Jan Beneš, Petr Němec, Helena Bedáňová, Jan Pirk, Ivan Málek, Josef Kautzner, and Vojtěch Melenovský. "Geographic variation in the access to heart transplantation in the Czech Republic." Cor et Vasa 58, no. 4 (August 1, 2016): e396-e402. http://dx.doi.org/10.1016/j.crvasa.2015.09.011.

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13

Málek, Ivan, and Markéta Hegarová. "Characteristics of patients on the waiting list for heart transplantation." Cor et Vasa 52, no. 3 (March 1, 2010): 149–53. http://dx.doi.org/10.33678/cor.2010.041.

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14

Adam, Zdeněk, Eva Ozábalová, Petr Němec, Helena Bedáňová, Milan Kuman, Jan Krejčí, Lenka Špinarová, et al. "Heart transplantation and follow-up treatment with AL-amyloidosis in 5 patients." Vnitřní lékařství 64, no. 4 (April 1, 2018): 441–49. http://dx.doi.org/10.36290/vnl.2018.063.

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15

Jatene, Fábio Biscegli, Paulo Manuel Pêgo-Fernandes, and Israel Lopes de Medeiros. "Transplante pulmonar." Revista de Medicina 88, no. 3 (September 6, 2009): 111–22. http://dx.doi.org/10.11606/issn.1679-9836.v88i3p111-122.

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Desde o primeiro transplante pulmonar bem sucedido na década de 80, essa se tornou uma terapia bem estabelecida para pacientes com pneumopatia crônica não-neoplásica em estágio terminal. São pacientes portadores de doença pulmonar obstrutiva crônica, fibrose pulmonar idiopática, fibrose cística e hipertensão pulmonar primária em um estágio no qual a terapia clínica não é mais efetiva. Atualmente, são cerca de 150 centros em todo o mundo realizando mais de 2500 transplantes de pulmão todo ano. O aprimoramento das técnicas cirúrgicas e anestésicas, bem como dos cuidados perioperatórios (terapia intensiva, imunossupressão, profilaxia de infecções) contribuíram para aumentar a sobrevida e a qualidade de vida dos pacientes transplantados. Nessa revisão, abordaremos os critérios de seleção de doadores e receptores, e as técnicas de preservação pulmonar atualmente utilizadas. Também discutiremos a técnica operatória adotada em nossa instituição para a extração e o implante dos órgãos. Por fim, citaremos as estatísticas mais recentes divulgadas pela International Society of Heart and Lung Transplantation, incluindo todos os transplantes realizados até o primeiro semestre de 2008.

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16

Rohmah, Lailatu. "Kontekstualisasi Hadis Tentang Transplantasi." Hikmah: Journal of Islamic Studies 14, no. 2 (November 25, 2018): 105. http://dx.doi.org/10.47466/hikmah.v14i2.109.

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Organ transplantation as a medical technique is a new improvement and discovery in the world of modern medicine. For example, the first successfully heart Transplantation was carried out in 1967. Until now many organs or tissues can be transplanted, including skin, cornea, bones, blood vessels, kidneys, heart, liver, lungs, and pancreas. While in the review of Islamic law, transplantation is a contemporary issue, and there are no texts in the Qur’an and Hadith that explicitly mentioning transplantation. Because of its increasing widespread of the organ transplants, it is regarded obligatory to study further in the Islamic perspective or Hadith on organ transplants. In this article, the author analyzes the Hadith relating to the transplants, then relates to the social context and various opinions of the scholars about organ transplants. Keywords: Contextualization Hadith, Transplantation Transplantasi organ sebagai teknik pengobatan merupakan kemajuan dan temuan baru dalam dunia kedokteran modern. Misalnya, Transplantasi jantung pertama kali sukses dilakukan tahun 1967. Hingga kini sudah banyak organ atau jaringan yang dapat ditransplantasikan, antara lain kulit, kornea, tulang, pembuluh darah, ginjal, jantung, hati, paru, dan pankreas. Sementara dalam tinjauan hukum Islam transplantasi ini merupakan masalah kontemporer, dan tidak ada nash al- Qur’an dan hadis yang secara eksplisit menyebutkan tentang transplantasi tersebut. Karena semakin maraknya transplantasi organ ini, maka dipandang perlu dikaji lebih jauh dalam perspektif Islam tentang transplantasi organ tersebut. Dalam artikel ini, penulis mengkaji hadis yang berkaitan dengan transplantasi, kemudian dikaitkan dengan konteks sosial serta berbagai pendapat ulama tentang transplantasi organ tubuh. Kata Kunci: Kontekstualisasi, Hadis, Transplantasi

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17

Gazdič, Tomáš, Ivan Málek, and Josef Kautzner. "Antibody-mediated rejection after heart transplantation - an overview of current concepts." Cor et Vasa 52, no. 11-12 (November 1, 2010): 713–20. http://dx.doi.org/10.33678/cor.2010.177.

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18

Pavlíková, Petra. "Heart failure in a patient with cirrhotic cardiomyopathy as an unusual indication for liver transplantation." Gastroenterologie a hepatologie 74, no. 5 (October 30, 2020): 424–27. http://dx.doi.org/10.14735/amgh2020424.

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Cirrhotic cardiomyopathy is a heart disease that may develop in patients with significant portal hypertension and concomitant hyperdynamic circulation. It is a rare complication in which the diagnosis is difficult and the prognosis is not clear. We present a case of female patient with liver cirrhosis who underwent liver transplantation in 2017 due to repeated heart failure in cirrhotic cardiomyopathy. Before being indicated for liver transplantation, the patient had to be repeatedly and very carefully examined by cardiologist to rule out other primary heart disease. The post-transplantation course was favourable in this patient with good synthetic function of the liver graft. The cardiac status returned to a normal state after 6 months.

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19

Dufková, Blanka, Ivan Málek, and Yevheniya Vymětalová. "Switching to tacrolimus in heart transplant recipients with recurrent rejection episodes." Cor et Vasa 48, no. 12 (December 1, 2006): 421–25. http://dx.doi.org/10.33678/cor.2006.135.

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20

Anton, Mary-Ellen, and Debra Schatz-Salzman. "Expanding the Donor Pool: The Elderly Non—Heart-Beating Donor." Progress in Transplantation 13, no. 1 (March 2003): 24–27. http://dx.doi.org/10.1177/152692480301300105.

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The need for transplantable organs continues to far outweigh the number of organs available for transplantation through donation. To date, many avenues for expanding the donor pool have been explored, including Non—Heart-beating donor protocols and the expansion of acceptable criteria. This case study reviews the successful procurement of a liver and kidney from a 72-year-old Non—Heart-beating donor.

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21

Machado Couto, Eugenia, Nathalia Brum Cavalcanti, Maria Clara Gervasoni Fumiere, Rafael Rangel Spelta, Lucas Antônio Morais de Abreu, Matheo Rocha Marques Luz, Verônica Cordeiro Mendes Tavares, et al. "TRANSPLANTE CARDÍACO: CRITÉRIOS DE INCLUSÃO E EXCLUSÃO." RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218 3, no. 9 (September 7, 2022): e391858. http://dx.doi.org/10.47820/recima21.v3i9.1858.

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A insuficiência cardíaca leva a uma oxigenação deficitária dos tecidos que, em contrapartida, aumenta o esforço miocárdico como tentativa de compensação da disfunção da oferta sanguínea, fato que contribui para o aumento de desfechos desfavoráveis para pacientes cardiopatas. Pacientes classificados com maior gravidade de acordo com a New York Heart Association (NYHA) podem ser candidatos ao padrão-ouro de tratamento: o transplante cardíaco. Para que sejam eleitos, é necessário que se enquadrem em critérios de inclusão e exclusão, a fim de que se evitem complicações pós-transplante cardíaco. O objetivo desse trabalho é fazer uma revisão de literatura dos estudos recentes relacionados ao tema acerca desses fatores que tornam pacientes cardiopatas elegíveis ou não ao transplante cardíaco.

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22

Malickaitė, Radvilė, Laimutė Jurgauskienė, Stanislava Simanavičienė, Vytė Valerija Maneikienė, Rita Sudikienė, and Kęstutis Ručinskas. "Imuninė stebėsena širdies transplantacijoje: atmetimo reakcijos poveikis T limfocitų žymenų ekspresijai." Lietuvos chirurgija 8, no. 3 (January 1, 2010): 0. http://dx.doi.org/10.15388/lietchirur.2010.3.2103.

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Radvilė Malickaitė, Laimutė Jurgauskienė, Stanislava Simanavičienė, Vytė Valerija Maneikienė, Rita Sudikienė, Kęstutis Ručinskas Vilniaus universiteto Širdies ir kraujagyslių ligų klinikos Širdies chirurgijos centras, Santariškių g. 2, LT-08661 Vilnius El. paštas: Radvile.Malickaite@santa.lt Darbo tikslas: Nustatyti Vilniaus universiteto ligoninės Santariškių klinikų Širdies chirurgijos centre atliekamos širdies transplantacijos įtaką T limfocitų aktyvumo rodikliams, įvertinti imuninės stebėsenos tinkamumą ūminiam transplantato atmetimui prognozuoti. Ligoniai ir metodai: Retrospektyviai analizuotas dvidešimt vieno širdies recipiento imuninių rodiklių kitimas esant normaliai potransplantacinei būklei ir ūminiam transplantato atmetimui. Periferinio kraujo imunokompetentinių ląstelių CD3+CD103+, CD4+CD103+, CD8+CD103+, CD3+CD134+, CD4+CD134+, CD8+CD134+, CD8+CD57+ ir CD8+CD38+ procentas nustatytas tėkmės citometrijos būdu. Ūminis transplantato atmetimas vertintas pagal histologinius endomiokardinės biopsijos radinius. Rezultatai: Esant ūminio atmetimo epizodams, kai endomiokardo biopsijos įvertintos ≥ 2R (3A) laipsniu, reikšmingai didėja integrino CD103 (p < 0,0001), kostimuliacinio receptoriaus CD134 (p = 0,005), antigeno CD57 (p = 0,005) ir ląstelių paviršiaus glikoproteino CD38 (p = 0,015) ekspresija citotoksinių CD8+ limfocitų paviršiuje. Išvados: Imuninė periferinio kraujo limfocitų būklės stebėsena gali būti taikoma po transplantacijos skiriamam imunosupresiniam gydymui įvertinti numatant didelę ūminio atmetimo tikimybę. Reikšminiai žodžiai: kiaušidžių cistos, supiktybėjimo rizika, piktybiškumo rizikos indeksas, ultragarsinis tyrimas, Ca-125 antigenas, chirurginis gydymas Measuring T cell reactivity for predicting heart transplant rejection Radvilė Malickaitė, Laimutė Jurgauskienė, Stanislava Simanavičienė, Vytė Valerija Maneikienė, Rita Sudikienė, Kęstutis Ručinskas Vilnius University, Clinic of Cardiovascular Diseases, Centre of Heart sSurgery, Santariškių str. 2, LT-08661 Vilnius, Lithuania E-mail: Radvile.Malickaite@santa.lt Objective: We aimed to analyze alterations in peripheral blood T-cell subset activation compared with endomyocardial byopsy findings. Patients and methods: The study included in total twenty-one heart recipients grafted 1997–2007 at the Vilnius Heart sSurgery cCenter. T-cell activation markers CD3+CD103+, CD4+CD103+, CD8+CD103+, CD3+CD134+, CD4+CD134+, CD8+CD134+, CD8+CD57+ ir CD8+CD38+ were detected by two-color flow cytometry. Rejection was graded according to the ISHLT (the International Society of Heart and Lung Transplantation) grading system. Results: In case of ≥ 2R (3A) rejection episodes, a significant increase in the expression of integrin CD103 (p < 0.0001), co-stimulatory receptor CD134 (p = 0.005), antigen CD57 (p = 0.005) and surface glycoprotein CD38 (p = 0.015) on CD8+ T lymphocytes has been revealed. Conclusion: Immune monitoring performed on peripheral blood can be used for the assessment of immunosuppression therapy on transplant recipients’ immune response and for determining the risk of rejection. Key words: heart transplantation, acute rejection, and immune activation

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23

Bedáňová, Helena, Erik Petrikovits, Josef Nečas, Petr Pavlík, Pavel Studeník, Jiří Ondrášek, Jan Černý, Petr Breinek, and Lenka Špinarová. "NT-proBNP as a non-invasive marker of acute rejection in heart transplant recipients." Cor et Vasa 48, no. 11 (November 1, 2006): 388–90. http://dx.doi.org/10.33678/cor.2006.125.

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24

Hošková, Lenka, Janka Franeková, Ivan Málek, Peter Sečník, Jan Pirk, Josef Kautzner, Ondřej Szárszoi, and Antonín Jabor. "Relationship of cardiorenal biomarkers for prediction of renal dysfunction in patients after heart transplantation." Cor et Vasa 55, no. 4 (August 1, 2013): e364-e369. http://dx.doi.org/10.1016/j.crvasa.2013.03.004.

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25

Vojtičková, Lenka, Miloš Kubánek, Jana Bínová, Jiří Gurka, Markéta Hegarová, Marianna Podzimková, Lenka Hošková, et al. "(Outcomes of pregnancy in pre-existing cardiomyopathy and after heart transplantation)." Cor et Vasa 64, no. 4 (September 1, 2022): 381–89. http://dx.doi.org/10.33678/cor.2021.142.

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26

Dorazilová, Zora, Ivan Málek, Jan Pirk, Mariana Podzimková, and Lenka Hošková. "The program of heart transplantation at IKEM from 31 January 1984 through 31 May 2005." Cor et Vasa 48, no. 3 (March 1, 2006): 98–107. http://dx.doi.org/10.33678/cor.2006.035.

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27

Marek, Dan, Alan Bulava, and Jan Lukl. "Bridge to heart transplantation by a combination of levosimendan and biventricular pacing in a patient with end-stage refractory heart failure." Cor et Vasa 53, no. 3 (March 1, 2011): 158–62. http://dx.doi.org/10.33678/cor.2011.036.

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28

Skalická, Blanka, Ivan Málek, Yevheniya Vymětalová, Lenka Hošková, Mariana Podzimková, and Josef Kautzner. "The efficacy and safety of combination therapy with atorvastatin and tacrolimus in heart transplant recipients." Cor et Vasa 50, no. 10 (October 1, 2008): 368–72. http://dx.doi.org/10.33678/cor.2008.134.

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29

Harjula, Ari, John C. Baldwin, Henry D. Tazelaar, Bruce A. Reitz, and Norman E. Shumway. "MINIMAL LUNG PATHOLOGY IN LONG-TERM PRIMATE SURVIVORS OF HEART-LUNG TRANSPLANTATIO." Transplantation 44, no. 6 (December 1987): 852–54. http://dx.doi.org/10.1097/00007890-198712000-00030.

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30

Pessoa, Vera Lúcia Mendes de Paula, Jéssica Naiane Gama da Silva, Virna Ribeiro Feitosa Cestari, Raquel Sampaio Florêncio, Teresa Cristina de Freitas, and Paulo Ricardo Da Silva Justino. "Outpatient nursing care: perception of the heart transplant patients on outpatient nursing consultation Assistência de enfermagem ambulatorial: percepção de transplantados cardíacos sobre a consulta de enfermagem ambulatorial." Revista de Pesquisa: Cuidado é Fundamental Online 9, no. 4 (October 31, 2017): 984. http://dx.doi.org/10.9789/2175-5361.2017.v9i4.984-989.

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ResumoObjetivo: Conhecer a percepção de transplantados cardíacos em relação à consulta de enfermagem em um ambulatório na Unidade de Transplante e Insuficiência Cardíaca (UTIC). Método: Estudo descritivo, de abordagem qualitativa, realizado na UTIC de um hospital público, localizado em Fortaleza, Ceará, de julho a novembro de 2013, com 11 pacientes transplantados cardíacos. Os discursos foram obtidos através da entrevista semiestruturada e organizados segundo os pressupostos teóricos da hermenêutica. Resultados: Os pacientes revelaram o impacto sofrido pelo transplante cardíaco e satisfação no acolhimento pelos profissionais, em especial, a enfermeira. Expressaram o reconhecimento das orientações prestadas, das modificações estabelecidas nesse processo e do vínculo entre enfermeira-paciente. Conclusão:Os transplantados cardíacos compreenderam que a enfermeira age de forma humanizada, acolhedora, cria vínculos e promove o autocuidado a fim de garantir melhorias na saúde, por meio da consulta de enfermagem ambulatorial. Descritores: Transplante de coração, Ambulatório hospitalar, Enfermagem.

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31

Schiaffonati, Luisa, Lidia Bardella, Gaetano Cairo, Emilia Rappocciolo, Lorenza Tacchini, and Aldo Bernelli-Zazzera. "Constitutive and Induced Synthesis of Heat Shock Proteins in Transplantable Hepatomas." Tumori Journal 73, no. 6 (December 1987): 559–65. http://dx.doi.org/10.1177/030089168707300604.

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The synthesis of heat shock proteins (HSP) was studied in rat liver and in a series of transplantable Morris hepatomas with different growth rates, subjected to heat shock in vivo and in vitro. Different from the liver, hepatomas synthesized HSP constitutively, i.e., also before exposure to heat. This constitutive synthesis was low and limited to one HSP in the slowest-growing tumor, more marked and involving other HSP in the intermediate- and fast-growing hepatomas. In tumor that synthesized HSP constitutively, the induction of HSP in response to heat was proportionately reduced. These patterns of reaction were essentially similar in vivo ad in vitro. The amount of HSP 68 was well correlated to the levels of its mRNA in liver and in all hepatomas, whereas the increase in HSP 89 was accompanied by a corresponding increase in the related mRNA in liver and in slow-growing hepatoma, not in the other tumors, thus suggesting a different mechanism of control of HSP 89 synthesis in the more malignant hepatomas.

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32

Poptsov, V. N., and E. N. Zolotova. "HEART TRANSPLANTATION IN DIABETIC RECIPIENTS." Russian Journal of Transplantology and Artificial Organs 20, no. 1 (April 24, 2018): 120–26. http://dx.doi.org/10.15825/1995-1191-2018-1-120-126.

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Diabetes mellitus is one of the most prevalent chronic metabolic disorders. Its role in patients with heart transplantation is not unifi ed. According to some authors, post-transplantation diabetes mellitus increases the risk of acute rejections and infections, increases the incidence of coronary artery disease of the graft and reduces long-term survival of patients with heart transplantation. On the other hand other studies did not confi rm these fi ndings. However, when diabetic patients were stratifi ed by disease severity, recipients with less severe disease achieved better survival. Accordingly, posttransplant survival was not signifi cantly different between recipients with uncomplicated diabetes and nondiabetic recipients. Diabetes alone should not be a contraindication to heart transplantation. Well-selected diabetic patients achieve the same survival as nondiabetic patients. Conversely, patients with complicated diabetes have signifi cantly worse survival. Therefore, given the critical shortage of transplantable organs, maximal benefi t may be achieved by exploring alternative treatment options in individuals with severe diabetes. These include use of high-risk transplant lists and destination therapy.

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33

Špinarová, Lenka, Petr Hude, Jan Krejčí, Hana Poloczková, Eva Ozábalová, Helena Bedáňová, Petr Němec, Jiří Ondrášek, Jan Černý, and Jiří Vítovec. "The fate of patients surviving at 10 years after heart transplantation with a focus on the incidence of malignant disease." Cor et Vasa 51, no. 6 (June 1, 2009): 415–18. http://dx.doi.org/10.33678/cor.2009.106.

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34

Yamato, Masayuki, and Teruo Okano. "Nanotechnology-Based Cell Sheet Engineering for Regenerative Medicine." Advances in Science and Technology 53 (October 2006): 74–78. http://dx.doi.org/10.4028/www.scientific.net/ast.53.74.

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In order to realize true regenerative medicine, we have developed a novel technology for the reconstruction of tissues and organs by utilizing intelligent materials including temperature-responsive polymers. We developed temperature-responsive culture surfaces, on which temperature-responsive polymers are covalently immobilized. Cells are cultured on the surfaces at 37°C, and harvested as transplantable cell sheets by reducing temperature to 20°C. With these cell sheets we regenerate various kinds of tissues such as cornea and heart.

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35

Scanlon, Dennis P., Christopher S. Hollenbeak, Woolton Lee, Evan Loh, and Peter A. Ubel. "Does Competition For Transplantable Hearts Encourage ‘Gaming’ Of The Waiting List?" Health Affairs 23, no. 2 (March 2004): 191–98. http://dx.doi.org/10.1377/hlthaff.23.2.191.

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36

Neskubina, Irina V., Elena M. Frantsiyants, Valeria A. Bandovkina, Natalia D. Cheryarina, Alla I. Shikhlyarova, Ekaterina I. Surikova, Irina V. Kaplieva, et al. "Comorbidity affects Вcl-2 levels in mitochondria in C57BL/6 mice with transplantable B16/F10 melanoma." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e21581-e21581. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21581.

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e21581 Background: Overexpression of the Bcl-2 protein inhibits apoptosis and promotes carcinogenesis. Stress causes signaling leading to cell buffering with Bcl-2 protein above acceptable levels. The purpose of the study was to analyze the influence of comorbidity – chronic neurogenic pain (CNP) – on the Bcl-2 levels in mitochondria of cells of melanoma, the heart, skin and brain in female mice with growing tumors. Methods: Female С57ВL/6 mice were divided into groups: intact group (n = 21); control group with a CNP model – bilateral sciatic nerve ligation (n = 21); group M – B16/F10 melanoma (n = 63); CNP+M group – B16/F10 melanoma was transplanted 3 weeks after the CNP model creation (n = 63). The concentration of Bcl-2 (ng/mg of protein) was determined in mitochondrial samples by ELISA (Thermo Fisher Scientific, Austria). Statictical analysis of results: Statistica 10.0. Results: CNP decreased the Bcl-2 level in heart mitochondria by 1.3 times (p < 0.05), but increased it in skin and brain mitochondria by 5.8 and 1.3 times, respectively. Similar changes were observed in melanoma growth 1 week after its transplantation: Bcl-2 levels decreased in heart mitochondria by 1.3 times, and increased in the skin and brain by 8.9 and 1.3 times, respectively. After 2 weeks of the tumor growth, Bcl-2 in brain mitochondria decreased by 1.7 times, and it started declining in the skin by the 3rd week – by 4 times, compared to intact females. Bcl-2 in tumor mitochondria exceeded the values in the skin by more than 4 times throughout the experiment. Tumor growth in presence of CNP caused a decrease in Bcl-2 in brain mitochondria by 2.4 times after 3 weeks, and in the heart and skin – by 2 and 1.7 times, respectively, after 2 weeks. Bcl-2 in tumor mitochondria in presence of CNP was lower than in the intact skin on average by 1.8 times throughout the experiment. Conclusions: CNP as a comorbidity caused a modulating effect on the mechanisms of survival and apoptosis of cells both in the tumor and in the main organs providing the vital functions of the body - the brain and heart, and also affects the target organ of melanoma - the skin. The results demonstrated the ability of comorbidity to change levels of Bcl-2 in mitochondria depending on the stage of tumor development.

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Bedáňová, Helena, Marek Orban, Martin Třetina, Aleš Tomášek, Petr Malík, Petr Fila, Vladimír Horváth, Jiří Ondrášek, Radka Štěpánová, and Petr Němec. "Prevalence of donor-transmitted atherosclerosis-Clinical utility of intracoronary ultrasound early after heart transplantation. A single-center study." Cor et Vasa 55, no. 4 (August 1, 2013): e309-e314. http://dx.doi.org/10.1016/j.crvasa.2013.03.012.

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Drott, C., C. Lönnroth, and K. Lundholm. "Protein synthesis, myosin ATPase activity and myofibrillar protein composition in hearts from tumour-bearing rats and mice." Biochemical Journal 264, no. 1 (November 15, 1989): 191–98. http://dx.doi.org/10.1042/bj2640191.

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Growing rats and adult weight-stable mice bearing a transplantable methylcholanthrene-induced sarcoma were compared with animals with various states of malnutrition. Heart protein synthesis was measured in vivo. Myocardial RNA, myofibrillar protein composition and the Ca2+-activated ATPase activity in heavy chains of native myosin were measured. ‘Fingerprints’ were made from myosin by trypsin treatment to evaluate possible structural changes in the protein. Cardiac protein-synthesis rate was decreased by 20% in growing tumour-bearing rats, by 35% in protein-malnourished (rats) and by 47% in starved rats, compared with freely fed controls (P less than 0.05). Adult tumour-bearing mice showed no significant decrease in myocardial protein synthesis. Pair-weighed control mice had significantly depressed heart protein synthesis. Protein translational efficiency was maintained in both tumour-bearing rats and mice, but was decreased in several groups of malnourished control animals. The Ca2+-activated myosin ATPase activity was decreased in all groups of malnourished animals, including tumour-bearing mice and rats, without any evidence of a change in cardiac isomyosin composition. We conclude that loss of cardiac muscle mass in tumour disease is communicated by both depressed synthesis and increased degradation largely owing to anorexia and host malnutrition. Increased adrenergic sensitivity in hearts from tumour-bearing and malnourished animals is not communicated by increased Ca2+-activated ATPase activity. This may be down-regulated in all groups with malnutrition, without any observable alterations in the isomyosin profile.

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Pedrotti, P., G. Masciocco, L. D'Angelo, A. Milazzo, G. Quattrocchi, F. Zanotti, M. Frigerio, A. Roghi, and O. Rimoldi. "939CMR T1 Mapping Pre And Post Contrast Characterizes The Myocardium In Heart Transplantat Recipients Without Rejection." European Heart Journal - Cardiovascular Imaging 14, suppl_1 (May 1, 2013): i2. http://dx.doi.org/10.1093/ehjci/jet070c.

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Abizanda, Gloria, Leyre López-Muneta, Javier Linares, Luis I. Ramos, Arantxa Baraibar-Churio, Miriam Bobadilla, Elena Iglesias, et al. "Local Preirradiation of Infarcted Cardiac Tissue Substantially Enhances Cell Engraftment." International Journal of Molecular Sciences 22, no. 17 (August 24, 2021): 9126. http://dx.doi.org/10.3390/ijms22179126.

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The success of cell therapy for the treatment of myocardial infarction depends on finding novel approaches that can substantially implement the engraftment of the transplanted cells. In order to enhance cell engraftment, most studies have focused on the pretreatment of transplantable cells. Here we have considered an alternative approach that involves the preconditioning of infarcted heart tissue to reduce endogenous cell activity and thus provide an advantage to our exogenous cells. This treatment is routinely used in other tissues such as bone marrow and skeletal muscle to improve cell engraftment, but it has never been taken in cardiac tissue. To avoid long-term cardiotoxicity induced by full heart irradiation we developed a rat model of a catheter-based heart irradiation system to locally impact a delimited region of the infarcted cardiac tissue. As proof of concept, we transferred ZsGreen+ iPSCs in the infarcted heart, due to their ease of use and detection. We found a very significant increase in cell engraftment in preirradiated rats. In this study, we demonstrate for the first time that preconditioning the infarcted cardiac tissue with local irradiation can substantially enhance cell engraftment.

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Feldman, Eric A. "Culture, Conflict, and Cost: Perspectives on Brain Death in Japan." International Journal of Technology Assessment in Health Care 10, no. 3 (1994): 447–63. http://dx.doi.org/10.1017/s026646230000667x.

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AbstractJapanese surgeons have performed only one heart transplant in the quarter century since the procedure was developed. Possessing the requisite training and technology, transplant surgeons have been stymied by several factors that elude professional and political solution. Most critically, the lack of a brain death standard limits the availability of transplantable organs. Mistrust of the medical profession, traditional outlooks on death, and the primacy placed on consensual decision making have fueled debate about brain death and transplantation. Volatile and value laden, these issues have overwhelmed the discussion of health care resources, equal access to high-technology medical procedures, and insurance coverage for transplantation.

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Pěnička, Martin, Petr Widimský, Tomasz Siminiak, Otto Lang, Karol Čurila, and Kateřina Hesová. "Cellular therapy of coronary heart disease: a summary of state of the art, limitations and prospects. Part One. Introduction, techniques of myocardial cell transplantation, skeletal myoblasts." Cor et Vasa 48, no. 5 (May 1, 2006): 186–90. http://dx.doi.org/10.33678/cor.2006.057.

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Melo, Cynthia de Freitas, Nathalia Gabriella Da Justa Mota, Annaline Luzia Da Silva, and João Lins De Araújo Neto. "Entre o pulsar e o morrer: a vivência de pacientes que esperam o transplante cardíaco." Enfermería Global 19, no. 2 (March 14, 2020): 351–89. http://dx.doi.org/10.6018/eglobal.379421.

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Introducción: El trasplante es el enfoque patrón-oro en el tratamiento de la insuficiencia cardíaca, resultando en una mayor sobrevida y calidad de vida. Sin embargo, la alta demanda y escasez de donantes generan largas filas, en las que los pacientes experimentan sentimientos ambiguos de esperanza y frustación, en medio de la vida y la muerte.Objetivo: Comprender la vivencia en la cola de espera del trasplante cardíaco desde la perspectiva del paciente y su familia.Método: Investigación descriptiva y exploratoria, de abordaje cualitativo, realizada con 12 participantes: 6 pacientes que están en fila de espera para trasplante cardíaco y 6 familiares. En el programa Iramuteq (Interfaz de R para los Analyses Multimensionnelles de Textes et de Questionnaires), respondieron un guión de entrevista semiestructurado, que fue evaluado por medio de análisis textual en el software Iramuteq.Resultados: Se evidenció que el descubrimiento del diagnóstico y de la necesidad de trasplante está impregnado por sentimientos de tristeza y miedo, que demandan reorganización de la estructura familiar y uso de diferentes estrategias de enfrentamiento. Entre las dificultades vivenciadas en la espera por un órgano se contempla el surgimiento de intercurrencias clínicas, que pueden quitarle la vida o imposibilitar la cirugía, y el constante rechazo de la familia de posibles donantes.Conclusión: La cola de espera para trasplante cardíaco se configura como un momento de "carrera contra el tiempo por la vida", impregnada por ansiedad, esperanza y frustración, en la que el apoyo familiar es fundamental. Se hace fundamental también la inversión en campañas de donación de órganos y capacitación de profesionales para hacer un abordaje correcto a los familiares de posibles donantes, acogiendo su duelo y aclarando sus dudas. Introduction: Transplantation is the gold standard approach in the treatment of heart failure, resulting in longer survival and quality of life. However, high demand and donor shortage lead to long queues in which patients experience ambiguous feelings of hope and frustration between life and death.Objective: To understand the experience in the heart transplant waiting list from the perspective of patients and their families.Method: Descriptive and exploratory research with a qualitative approach, conducted with 12 participants: six patients who were waiting for heart transplantation and six family members. They answered a semi-structured interview script, which was evaluated by textual analysis using the Iramuteq software (Interface for R for Les Multesanalysis de Textes et de Questionnaires).Results: It was evident that the discovery of the diagnosis and the need for transplantation was permeated by feelings of sadness and fear, requiring reorganization of the family structure and use of different coping strategies. The difficulties experienced in waiting for an organ include the emergence of clinical complications that can take the life of the patient or prevent surgery, and the constant refusal of possible donors on the part of the family.Conclusion: The waiting list for heart transplantation is a moment of “race against time for life”, permeated by anxiety, hope and frustration, in which family support is essential. It is also essential to invest in organ donation campaigns and training professionals to make a correct approach to families when it comes to talk about potential donors, embracing their grief and clarifying their doubts.

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DuBois, James M. "Non-Heart-Beating Organ Donation: A Defense of the Required Determination of Death." Journal of Law, Medicine & Ethics 27, no. 2 (1999): 126–36. http://dx.doi.org/10.1111/j.1748-720x.1999.tb01445.x.

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The family of a patient who is unconscious and respirator-dependent has made a decision to discontinue medical treatment. The patient had signed a donor card. The family wants to respect this decision, and agrees to non-heart-beating organ donation. Consequently, as the patient is weaned from the ventilator, he is prepped for organ explantation. Two minutes after the patient goes into cardiac arrest, he is declared dead and the transplant team arrives to begin organ procurement. At the time retrieval begins, it is not certain that the patient's brain is dead or that cardiac function cannot be restored. Procurement follows uneventfully, and two transplantable kidneys are retrieved.Many people now consider such cases of non-heart-beating organ donation to be ethically permissible. However, widespread disagreement persists as to how such practices are to be justified and whether such practices are compatible with the Uniform Declaration of Death Act (UDDA). In this paper, I argue that non-heart-beating organ donation can be ethically justified, that in the justified cases the patients are in fact dead, and that the early declarations of death required for such donation do comply with the UDDA.

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Howard, David H. "Producing Organ Donors." Journal of Economic Perspectives 21, no. 3 (July 1, 2007): 25–36. http://dx.doi.org/10.1257/jep.21.3.25.

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Organ transplantation is one of the greatest technological achievements of modern medicine, but the ability of patients to benefit from transplantation is limited by shortages of transplantable organs. The median waiting time for patients placed on the kidney transplant waiting list is over three years. Median waiting times for hearts and livers are seven months and two years, respectively. From 1995 to 2005, the number of patients placed on the waiting list for organ transplants grew at an annualized rate of 4 percent per year. As a result of the growth in the demand for organs, many observers have questioned whether the current system is capable of providing enough transplantable organs. Transplant physicians and policymakers are seriously debating proposals to pay donors and their families and to change the legal regime governing the process of obtaining consent to donation. This paper provides an overview of the rules and practices that govern the organ procurement system and reviews proposals to increase donation rates, with a focus on deceased donors.

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Oliveira Karasek Hazime, Desiree, Mariana Guimarães Rodrigues, Edílio Póvoa Lemes Neto, Vitória De Souza Endres, Manoela Melocro, Thaís Teixeira Duarte, Welton John Reis de Olégario, et al. "COMPLICAÇÕES PRECOCES E TARDIAS MAIS FREQUENTES PÓS-TRANSPLANTE CARDÍACO EM PACIENTES PORTADORES DE INSUFICIÊNCIA CARDÍACA." RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218 3, no. 10 (September 30, 2022): e3101928. http://dx.doi.org/10.47820/recima21.v3i10.1928.

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A doença cardiovascular é uma das principais causas de óbito no mundo, tendo a insuficiência cardíaca como sua principal complicação. Nos casos refratários, o transplante cardíaco é o padrão-ouro para o tratamento. Apesar disso, para que os pacientes sejam candidatos a essa abordagem cirúrgica, tanto os doadores, quanto os receptores necessitam passar por uma avaliação cautelosa dos critérios de inclusão e exclusão, de acordo com a New York Heart Association (NYHA), a fim de que se evitem complicações no pós-operatório. Dentre essas complicações, estão presentes as precoces e as tardias, objetivo de abordagem dessa revisão bibliográfica a partir de estudos relevantes relacionados ao tema.

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Kwek, Tong Kiat, Thomas WK Lew, Hui Ling Tan, and Sally Kong. "The Transplantable Organ Shortage in Singapore – Has Implementation of Presumed Consent to Organ Donation Made a Difference." Annals of the Academy of Medicine, Singapore 38, no. 4 (April 15, 2009): 346–53. http://dx.doi.org/10.47102/annals-acadmedsg.v38n4p346.

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The success of solid organ transplantation in the treatment of end-stage organ failure has fuelled a growing demand for transplantable organs worldwide that has far outstripped the supply from brain dead heart-beating donors. In Singapore, this has resulted in long waiting lists of patients for transplantable organs, especially kidneys. The Human Organ Transplant Act, introduced in 1987, is an opt-out scheme that presumes consent to removal of certain organs for transplantation upon death. Despite this legislation, the number of deceased organ donors in Singapore, at 7 to 9 per million population per year, remains low compared to many other developed countries. In this paper, we reviewed the clinical challenges and ethical dilemmas encountered in managing and identifying potential donors in the neurological intensive care unit (ICU) of a major general hospital in Singapore. The large variance in donor actualisation rates among local restructured hospitals, at 0% to 56.6% (median 8.8%), suggests that considerable room still exists for improvement. To address this, local hospitals need to review their processes and adopt changes and best practices that will ensure earlier identification of potential donors, avoid undue delays in diagnosing brain death, and provide optimal care of multi-organ donors to reduce donor loss from medical failures. Key words: Brain death, End-of-life, Multi-organ donor, Organ procurement, Opt-out

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Correia, Ana Rita, Margarida Manso, Roberto Roncon-Albuquerque Jr., Gerardo Oliveira, Carlos Silva, Francisco Cruz, and Tiago Antunes-Lopes. "Doação de Rins Após Paragem Cardiocirculatória: O Papel da Oxigenação por Membrana Extracorporal." Acta Urológica Portuguesa 36, no. 1-2 (September 21, 2019): 23–29. http://dx.doi.org/10.24915/aup.36.1-2.86.

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Introdução: A doença renal crónica é uma patologia prevalente, sendo significativo o número de doentes em estádio terminal cujas alternativas se resumem à terapêutica de substituição da função renal e ao transplante, sendo o último associado a maior qualidade de vida e a menor mortalidade. A procura crescente de rins para transplante tem aumentado o desfasamento relativamente aos rins disponíveis. Esse desfasamento impulsionou a pesquisa e desenvolvimento de alternativas aos dadores cadáver em morte cerebral, sendo os dadores após paragem cardiocirculatória uma alternativa viável. Estes obrigam a técnicas de preservação de órgão distintas, de forma a poder oferecer resultados funcionais sobreponíveis. O objetivo deste artigo foi rever a evidência recente sobre o papel da utilização da oxigenação por membrana extracorporal como técnica de preservação, na colheita de rins de dadores após paragem cardiocirculatória. Material e Métodos: Foi efectuada uma pesquisa na base PubMed/MEDLINE, utilizando as expressões: “kidney transplantation”; “non-heart-beating donor”; “donation after cardiac death”; “extracorporeal membrane oxygenation”; “abdominal normothermic perfusion”. Com os artigos selecionados, realizou- se uma revisão não sistemática, sumarizando a evidência recente sobre a utilização da oxigenação por membrana extracorporal na colheita de rins de dadores após paragem cardiocirculatória. Resultados: Verificou-se que os estudos sugerem com unanimidade que a oxigenação por membrana extracorporal é superior às outras técnicas de preservação utilizadas em dadores após paragem cardiocirculatória, uma vez que está associada a melhores resultados a curto prazo do aloenxerto renal. Relativamente aos dadores convencionais, em morte cerebral, a técnica permite resultado semelhantes, quando comparada com os dadores de morte cerebral de critérios expandidos. Discussão: A preservação de órgãos através da oxigenação por membrana extracorporal nos dadores após paragem cardiocirculatória permite resultados funcionais favoráveis e, por esse motivo, poderá contribuir para o aumento do pool de dadores. As dificuldades logísticas associadas à implementação da técnica restringem a sua utilização. Conclusão: A longo prazo, deverão ser criadas condições para a implementação em mais centros da oxigenação por membrana extracorporal nos dadores após paragem cardiocirculatória, aumentando o pool de rins disponíveis para transplante.

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Suprapta, Aloysius, Aditya Listyoko, and Susanthy Djajalaksana. "CPET : Gambaran Umum dan Penggunaan pada Pasien Gagal Jantung." Jurnal Klinik dan Riset Kesehatan 1, no. 2 (February 4, 2022): 101–15. http://dx.doi.org/10.11594/jk-risk.01.2.5.

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Cardiopulmonary exercise test (CPET) atau uji latih jantung paru merupakan modalitas non-invasif yang digunakan untuk menilai tingkat kebugaran seseorang. Penilaian atas mekanisme pertukaran gas yang terjadi di tahap respirasi secara breath – to - breath akan menggambarkan pertukaran gas di tingkat selular. Pemantauan pertukaran gas ini menjadi parameter dalam menilai tentang kelainan-kelaianan yang menyebabkan terganggunya proses metabolisme aerob di dalam tubuh. Paramater-parameter pada CPET ini membantu klinisi dalam memilah dan menilai faktor penyebab gangguan dypnea atau kelelahan saat aktivitas, apakah gangguan di sisi sistem pernafasan, sistem kardiovaskular, ataukah di sisi muskuloskeletal. Di samping itu, CPET juga menjadi modalitas dalam menentukan prognosis dan kelayakan transplantasi jantung pada klien dengan gagal jantung (heart failure). Penilaian peak VO2 ≥ 14 mL/kg/menit memberikan gambaran cumulative survival yang lebih baik pada pasien gagal jantung, dan O2 pulse ≥ 10 mL/beat menunjukkan event-free survival yang lebih baik.

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Mancuso, Teresa, Antonella Barone, Alessandro Salatino, Claudia Molinaro, Fabiola Marino, Mariangela Scalise, Michele Torella, et al. "Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair." International Journal of Molecular Sciences 21, no. 10 (May 25, 2020): 3725. http://dx.doi.org/10.3390/ijms21103725.

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Cardiac remuscularization has been the stated goal of the field of regenerative cardiology since its inception. Along with the refreshment of lost and dysfunctional cardiac muscle cells, the field of cell therapy has expanded in scope encompassing also the potential of the injected cells as cardioprotective and cardio-reparative agents for cardiovascular diseases. The latter has been the result of the findings that cell therapies so far tested in clinical trials exert their beneficial effects through paracrine mechanisms acting on the endogenous myocardial reparative/regenerative potential. The endogenous regenerative potential of the adult heart is still highly debated. While it has been widely accepted that adult cardiomyocytes (CMs) are renewed throughout life either in response to wear and tear and after injury, the rate and origin of this phenomenon are yet to be clarified. The adult heart harbors resident cardiac/stem progenitor cells (CSCs/CPCs), whose discovery and characterization were initially sufficient to explain CM renewal in response to physiological and pathological stresses, when also considering that adult CMs are terminally differentiated cells. The role of CSCs in CM formation in the adult heart has been however questioned by some recent genetic fate map studies, which have been proved to have serious limitations. Nevertheless, uncontested evidence shows that clonal CSCs are effective transplantable regenerative agents either for their direct myogenic differentiation and for their paracrine effects in the allogeneic setting. In particular, the paracrine potential of CSCs has been the focus of the recent investigation, whereby CSC-derived exosomes appear to harbor relevant regenerative and reparative signals underlying the beneficial effects of CSC transplantation. This review focuses on recent advances in our knowledge about the biological role of exosomes in heart tissue homeostasis and repair with the idea to use them as tools for new therapeutic biotechnologies for “cell-less” effective cardiac regeneration approaches.

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