Relevant bibliographies by topics / Heart development

Academic literature on the topic 'Heart development'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Heart development"

1

Leinwand, Leslie A. "Heart Development." Nature Medicine 5, no. 3 (March 1999): 260. http://dx.doi.org/10.1038/6466.

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Kiberstis, P. A. "DEVELOPMENT: Orchestrating a Heart-to-Heart." Science 289, no. 5479 (July 28, 2000): 509b—509. http://dx.doi.org/10.1126/science.289.5479.509b.

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3

Combs, Michelle D., and Katherine E. Yutzey. "Heart Valve Development." Circulation Research 105, no. 5 (August 28, 2009): 408–21. http://dx.doi.org/10.1161/circresaha.109.201566.

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Lyons, Gary E. "Vertebrate heart development." Current Opinion in Genetics & Development 6, no. 4 (August 1996): 454–60. http://dx.doi.org/10.1016/s0959-437x(96)80067-0.

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Armstrong, Ehrin J., and Joyce Bischoff. "Heart Valve Development." Circulation Research 95, no. 5 (September 3, 2004): 459–70. http://dx.doi.org/10.1161/01.res.0000141146.95728.da.

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Schleich, J.-M. "Development of the human heart: days 15-21." Heart 87, no. 5 (May 1, 2002): 487. http://dx.doi.org/10.1136/heart.87.5.487.

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Anderson, R. H. "Development and structure of the atrial septum." Heart 88, no. 1 (July 1, 2002): 104–10. http://dx.doi.org/10.1136/heart.88.1.104.

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Houyel, Lucile, and Sigolène M. Meilhac. "Heart Development and Congenital Structural Heart Defects." Annual Review of Genomics and Human Genetics 22, no. 1 (August 31, 2021): 257–84. http://dx.doi.org/10.1146/annurev-genom-083118-015012.

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Congenital heart disease is the most frequent birth defect and the leading cause of death for the fetus and in the first year of life. The wide phenotypic diversity of congenital heart defects requires expert diagnosis and sophisticated repair surgery. Although these defects have been described since the seventeenth century, it was only in 2005 that a consensus international nomenclature was adopted, followed by an international classification in 2017 to help provide better management of patients. Advances in genetic engineering, imaging, and omics analyses have uncovered mechanisms of heart formation and malformation in animal models, but approximately 80% of congenital heart defects have an unknown genetic origin. Here, we summarize current knowledge of congenital structural heart defects, intertwining clinical and fundamental research perspectives, with the aim to foster interdisciplinary collaborations at the cutting edge of each field. We also discuss remaining challenges in better understanding congenital heart defects and providing benefits to patients.
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Sun, Dong, An Huang, Gong Zhao, Robert Bernstein, Paul Forfia, Xiaobin Xu, Akos Koller, Gabor Kaley, and Thomas H. Hintze. "Reduced NO-dependent arteriolar dilation during the development of cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 278, no. 2 (February 1, 2000): H461—H468. http://dx.doi.org/10.1152/ajpheart.2000.278.2.h461.

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Our previous studies have suggested that there is reduced nitric oxide (NO) production in canine coronary blood vessels after the development of pacing-induced heart failure. The goal of these studies was to determine whether flow-induced NO-mediated dilation is altered in coronary arterioles during the development of heart failure. Subepicardial coronary arterioles (basal diameter 80 μm) were isolated from normal canine hearts, from hearts with dysfunction but no heart failure, and from hearts with severe cardiac decompensation. Arterioles were perfused at increasing flow or administered agonists with no flow in vitro. In arterioles from normal hearts, flow increased arteriolar diameter, with one-half of the response being NO dependent and one-half prostaglandin dependent. Shear stress-induced dilation was eliminated by removing the endothelium. Arterioles from normal hearts and hearts with dysfunction but no failure responded to increasing shear stress with dilation that reached a maximum at a shear stress of 20 dyn/cm2. In contrast, arterioles from failing hearts showed a reduced dilation, reaching only 55% of the dilation seen in vessels of normal hearts at a shear stress of 100 dyn/cm2. This remaining dilation was eliminated by indomethacin, suggesting that the NO-dependent component was absent in coronary microvessels after the development of heart failure. Similarly, agonist-induced NO-dependent coronary arteriolar dilation was markedly attenuated after the development of heart failure. After the development of severe dilated cardiomyopathy and heart failure, the NO-dependent component of both shear stress- and agonist-induced arteriolar dilation is reduced or entirely absent.
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Mustroph, Julian, Can M. Sag, Felix Bähr, Anna-Lena Schmidtmann, Shamindra N. Gupta, Alexander Dietz, M. M. Towhidul Islam, et al. "Loss of CASK Accelerates Heart Failure Development." Circulation Research 128, no. 8 (April 16, 2021): 1139–55. http://dx.doi.org/10.1161/circresaha.120.318170.

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Rationale: Increased myocardial activity of CaMKII (Ca/calmodulin-dependent kinase II) leads to heart failure and arrhythmias. In Drosophila neurons, interaction of CaMKII with CASK (Ca/CaM-dependent serine protein kinase) has been shown to inhibit CaMKII activity, but the consequences of this regulation for heart failure and ventricular arrhythmias are unknown. Objective: We hypothesize that CASK associates with CaMKII in human and mouse hearts thereby limiting CaMKII activity and that altering CASK expression in mice changes CaMKII activity accordingly, with functional consequences for contractile function and arrhythmias. Methods and Results: Immunoprecipitation revealed that CASK associates with CaMKII in human hearts. CASK expression is unaltered in heart failure but increased in patients with aortic stenosis. In mice, cardiomyocyte-specific knockout of CASK increased CaMKII-autophosphorylation at the stimulatory T287 site, but reduced phosphorylation at the inhibitory T305/306 site. Knockout of CASK mice showed increased CaMKII-dependent sarcoplasmic reticulum Ca leak, reduced sarcoplasmic reticulum Ca content, increased susceptibility to ventricular arrhythmias, greater loss of ejection fraction, and increased mortality after transverse aortic constriction. Intriguingly, stimulation of the cardiac glucagon-like peptide 1 receptor with exenatide increased CASK expression resulting in increased inhibitory CaMKII T305 phosphorylation, reduced CaMKII activity, and reduced sarcoplasmic reticulum Ca leak in wild type but not CASK-KO. Conclusions: CASK associates with CaMKII in the human heart. Knockout of CASK in mice increases CaMKII activity, leading to contractile dysfunction and arrhythmias. Increasing CASK expression reduces CaMKII activity, improves Ca handling and contractile function.
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Dissertations / Theses on the topic "Heart development"

1

Brown, Jessie Ann. "RUNX2 in Embryonic Heart Development and Heart Disease." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144250.

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2

Kim, WooJin. "Endothelial furin and heart development." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=87012.

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In mammals, seven proprotein convertases (PCs) cleave secretory proteins after basic residues. Four members of this family are called furin-like PCs: furin, PACE4, PC5, and PC7. Furin and PC7 are ubiquitous, while PACE4 and PC5 are widely expressed. In vitro, they share many substrates (redundancy). However, furin is essential during development. Inactivation of its gene (Pcsk3) in mouse resulted in lethality at embryonic day 11 (E11). The embryos exhibit multiple developmental defects, particularly related to the function of endothelial cells. In order to define the role of furin in endothelial cells, Pcsk3flox/flox mice carrying Tie2-Cre transgene that expresses Cre under the control of the Tie2 promoter were generated. Pcsk3flox/flox Tg(Tie2-cre) embryos (ecKO) do not survive, indicating that furin has an essential role in endothelial cells. We determined that lethality occurs after birth, and newborns have no visible phenotypes. However, magnetic resonance imaging revealed that ecKO mice exhibit a heart phenotype consisting of ventricular septal defects (VSD) and/or valve malformations.
Searching for candidate furin substrates, the loss of which exhibit VSD led us to analyze the processing of endothelin-1 (ET-1) and bone morphogenic protein 4 (BMP4). While proET-1 cleavage into ET-1 is reduced by 57% in absence of furin in ecKO lungs, proBMP4 activation into BMP4 was more than 90% lost in the heart of these mice. We conclude that proET-1 and proBMP-4 are in vivo substrates of furin and that the impaired processing of proBMP-4 is most likely the cause of the observed VSD in mice lacking endothelial furin. Further studies on other regulatory proteins of endothelial cell will unravel more specific in vivo functions of furin identifying other in vivo substrates.
Chez les mammifères, 7 proprotéines convertases (PC) clivent diverses protéines de sécrétion après les acides aminés basiques. Quatre membres de cette famille de convertases sont appelés: furin, PACE4, PC5 et PC7. Furin et PC7 sont omniprésents, tandis que PACE4 et PC5 sont largement exprimées. In vitro, ils ont beaucoup de substrats en commun. Cependant, la furin est essentielle pendant le développement. L'inactivation de son gène (Pcsk3) dans la souris a abouti à la mortalité embryonnaire au 11éme jour (E11). Les embryons montrent de multiples défauts liés au développement particulièrement reliés à la fonction des cellules endothéliales. Afin de définir le rôle de la furin dans les cellules endothéliales, des souris Pcsk3flox/flox portant le transgène Tie2-Cre qui exprime Cre dans le contrôle du promoteur Tie2 ont été produites. Les embryons Pcsk3flox/flox Tg(Tie2-cre) (aussi référés comme ecKO) ne survivent pas, indiquant que la furin a un rôle essentiel dans les cellules endothéliales. Nous avons déterminé que la mortalité arrive peu de temps après la naissance, ne montrant aucun phénotype apparent. Cependant, l'imagerie par résonance magnétique a révélé que les souris ecKO présentent un défaut septal ventriculaire (VSD).
Par la sélection du phénotype utilisant VSD sur les substrats de la furin, nous avons observé que proendothelin-1 (proET-1) a été moins produite dans le poumon de souris ecKO. Nous avons aussi démontré que la protéine morphogénétique-4 de l'os (proBMP-4) a été aussi moins clivée dans le coeur de souris ecKO. Ces observations soutiennent notre hypothèse que proET-1 et proBMP-4 sont les substrats in vivo de la furin et que la production altérée de proBMP-4 est la cause de VSD la plus probable. De nouvelles études sur d'autres protéines régulatrices des cellules endothéliales élucideront les fonctions in vivo plus spécifiques de la furin et l'identification d'autres substrats in vivo. fr
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Weinberger, Michael. "Epicardial heterogeneity during zebrafish heart development." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:3f26b933-5f17-4fe3-bd86-9211af69a558.

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The epicardium, a cell layer enveloping the heart muscle, drives embryonic heart development and heart repair in the adult zebrafish. Previous studies found the epicardium to consist of multiple cell populations with distinct phenotypes and functions. Here, I investigated epicardial heterogeneity in the developing zebrafish heart, focusing on the developmental gene program that is also reactivated during adult heart regeneration. Transcription factor 21 (Tcf21), T-box 18 (Tbx18) and Wilms' tumor suppressor 1b (Wt1b) are often used interchangeably to identify the zebrafish epicardium. Analyzing newly generated reporter lines and endogenous gene expression, I showed that the epicardial expression of tcf21, tbx18 and wt1b during development is heterogeneous. I then collected epicardial cells from newly generated reporter lines at 5 days-post-fertilization and performed single-cell RNA sequencing. I identified three distinct epicardial subpopulations with specific gene expression profiles. The first subpopulation expressed tcf21, tbx18 and wt1b and appeared to represent the main epicardial layer. The second subpopulation expressed tbx18, but not tcf21 or wt1b. Instead, it expressed smooth muscle markers and seemed restricted to the bulbus arteriosus. The third epicardial subpopulation only expressed tcf21 and resided within the epicardial layer. I compared the single-cell subpopulations with transcriptomic bulk data and visualized the expression of marker genes to investigate their spatial distribution. Using ATAC sequencing, I additionally identified open regulatory regions located in proximity to subpopulation-specific marker genes and showed subpopulation-specific activity in vivo. My results detail distinct cell populations in the developing zebrafish epicardium, likely to fulfil distinct and specific cellular functions. Future experiments will involve targeting signature genes enriched within each epicardial subpopulation, such as those encoding Adrenomedullin a (first subpopulation), Alpha Smooth Muscle Actin (second subpopulation) and Claudin 11a (third subpopulation), employing cell type-specific genome editing to test whether and how the identified heterogeneity underlies distinct epicardial cell fates and functions. Taken together, my work adds significantly to the understanding of the cellular and molecular basis of epicardial development and can offer novel insights in the context of heart regeneration.
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Harris, Michael Brennan. "Development of cardioprotection during an exercise program /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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Sharma, Pundrique Radheyshyam. "Programmed cell death during heart development." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272255.

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Ranawake, Manoja, and n/a. "Development of the artificial heart for serial production." University of Canberra. Industrial Design, 1995. http://erl.canberra.edu.au./public/adt-AUC20061113.151545.

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Heart disease is the principal cause of death in most industrialised countries. In the U.S.A. for example, 2.3 million individuals suffer from chronic heart failure, with an annual increase in numbers of 17%. It is estimated that 17,000 to 35,000 of them per year will die from this disease if they are not given either a heart transplant or an artificial heart. Unfortunately, the numbers of heart donors cannot meet the demand for transplantation, and, at present, the artificial heart is a prohibitively expensive alternative. The total artificial heart (TAH) intended for the total replacement of the natural heart is still some years away from realisation. However, the ventricular assist device (VAD) which is used temporarily to maintain an ailing heart is available now, although only in restricted numbers due to difficulties in processing the biocompatible materials used during manufacture. Consequently, such devices are expensive, costing anywhere from AUS$30,000 for the pump head to AUS$200,000 for a complete system. In this study, the Australian designed $quot;Spiral Vortex$quot; VAD was used to investigate fabrication techniques for use in the eventual cost-effective manufacture of a pump head costing approximately AUS$4,000. A second VAD originally designed at the Kolff Laboratory, University of Utah, U.S.A. was also used for comparative evaluation. The hard-shell Spiral Vortex VAD is intended to be used outside the body, while the soft-shell Kolff VAD has the advantage of being implantable for long-term use. They were cast from epoxy resin and vacuum formed from polyurethane, respectively. Several units of each were fabricated, including 60 of the Kolff VAD, for use in vitro and in vivo experiments. From these experiments it was found that both the Spiral Vortex and Kolff VADs could be fabricated to quality controllable standards. The Kolff VAD was used exclusively in chronic animal experiments, and was able to sustain sheep and goats for periods of up to five weeks. Furthermore, it became evident that techniques used in fabrication of the Kolff VAD could be adopted for use in the mass production of the Spiral Vortex VAD. The two other areas investigated in this study were the prosthetic heart valves and drive systems used for an artificial heart. A high percentage of the cost of an artificial heart is accounted for by the inflow/outflow valves. The trileaflet valve used in the Kolff VAD, which mimics the natural heart valve, was fabricated using inexpensive vacuum-forming techniques. Quality control was found to be adequate, with good flow characteristics which could be maintained for several weeks in animal experiments. Both the Spiral Vortex and Kolff VADs are pulsation pumps which require a pneumatic driver unit. This driver is the single most expensive component in a VAD system, costing upwards of AUS$150,000. The theoretical efficiency of a compact hydromechanical drive unit was investigated using a test rig to simulate an original design based primarily on proprietary components. Results obtained so far indicate that the proposed driver can operate only under limited conditions as a result of its severe reduction in size. By adopting mass production techniques wherever possible in the fabrication of the VAD (pump head) and valves, and by reducing the cost and size of the driver unit, it may therefore be possible to produce a cost effective ventricular assist device system.
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Sneesby, Kyra, and n/a. "Gene Expression in Embryonic Chick Heart Development." Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030924.153514.

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Establishment of the biochemical and molecular nature of cardiac development is essential for us to understand the relationship between genetic and morphological aspects of heart formation. The molecular mechanisms that underly heart development are still not clearly defined. To address this issue we have used two approaches to identify genes involved in early chick cardiac development. Differential display previously conducted in our laboratory led to the identification of two gene fragments differentially expressed in the heart that are further described in this thesis. The full-length cDNA sequence of both eukaryotic translation initiation factor-2b (eIF-2b) and NADH cytochrome b5 reductase (b5R) were isolated using library screening. The upreglation of these genes during heart development is expected given the heart is the first functional organ to form in vertebrates and protein synthesis and cell metabolism at this stage of development is maximal. Limitations in the differential display approach led to the development and optimisation of a subtractive hybridisation approach for use with small amounts of cells or tissue. To focus on cardiac gene expression during the initial phases of heart development, subtractive hybridization was performed between the cardiogenic lateral plate mesoderm of Hamburger and Hamilton stage 4 embryos and the heart primordia of stage 9 embryos. Of the 87 independent clones identified by this procedure, 59 matched known sequences with high homology, 25 matched unknown expressed sequence tag (EST) sequences with high homology, and 3 did not match any known sequence on the database. Known genes isolated included those involved in transcription, translation, cell signalling, RNA processing, and energy production. Two of these genes, high mobility group phosphoprotein A2 (HMGA2) and C1-20C, an unknown gene, were chosen for further characterisation. The role of each gene in early chick heart development and indeed development in general, was addressed using techniques such as in situ hybridisation, transfection analysis, in ovo electroporation and RNAi. HMGA2 is a nuclear phosphoprotein commonly referred to as an architectural transcription factor due to its ability to modulate DNA conformation. In keeping with this function, HMGA2/GFP fusion protein was shown to localise to the nucleus and in particular, the nucleolus. In situ hybridisation analysis suggested a role for HMGA2 in heart and somite development. HMGA2 expression was first detected at HH stage 5 in the lateral plate mesoderm, a region synonymous with cells specified to the cardiac fate. HMGA2 was also strongly expressed in the presomitic segmental plate mesoderm and as somites developed from the segmental plate mesoderm, the expression of HMGA2 showed an increasingly more restricted domain corresponding to the level of maturation of the somite. Restriction of HMGA2 expression was first detected in the dorsal region of the epithelial somite, then the dorsomedial lip of the dermomyotome, and finally the migrating epaxial myotome cells. The novel intronless gene, C1-20C, predicts a protein of 148 amino acids containing a putative zinc finger binding domain and prenyl binding motif. Zinc binding assays showed that the zinc finger domain of C1-20C/MBP fusion protein bound over six times the quantity of zinc compared to MBP alone, although not in a 1:1 stoichiometric molar ratio. C1-20C/GFP fusion protein was shown to localise to as yet unidentified intracellular cytoplasmic vesicular compartments. These compartments did not colocalise with the endosome/lysosome pathway, aparently ruling out a role for C1-20C in protein trafficking, recycling or degradation. Expression of C1-20C in the chick embryo suggests a possible role in heart and notochord development and preliminary results using siRNA suggest that C1-20C is involved in normal heart looping.
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Duong, Tiffany. "Mechanisms of NR2Fs in Heart Valve Development." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505149242216719.

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Makwana, Om. "THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/204310.

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Trichloroethylene (TCE; TRI; C2HCl3) is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregulation of Ca2+ homeostasis in a cardiomyocyte cell line after TCE exposure (Caldwell, Thorne et al. 2008). We hypothesized that misregulation of Ca2+ homeostasis alters myocyte function and leads to changes in embryonic blood flow. In turn, changes in cardiac flow are known to cause cardiac malformations. To investigate this hypothesis we dosed developing chick embryos in ovo with environmentally relevant doses of TCE (8 ppb and 800 ppb). We then isolated RNA from embryos at crucial time points in development for real-time PCR analysis of markers for altered blood flow. Based on this analysis, we observed effects on ET-1 (Endothelin-1), NOS-3 (Nitric Oxide Synthase-3) and Krüppel-Like Factor 2 (KLF2) expression relative to TCE exposure. Additionally, we assessed cardiomyocyte function by isolating chick E18 cardiomyocytes from embryos exposed to TCE in ovo. Cells were measured for rate of contraction after pulsing with extracellular Ca2+ and electrical stimulation at a frequency of 1.0 Hz. These functional data showed an effect on Ca2+ handling in cardiomyocytes exposed to TCE. To investigate an apparent non-monotypic effect in the heart where 8 ppb produced a stronger effect than 800 ppb, we isolated RNA from the developing heart and AV Canal to investigate the expression of several candidate Cytochrome P450s (CYPs) related to TCE metabolism. We observed a significant induction of multiple CYP2 family members in the developing heart after low dose TCE exposure. Together, these data suggest cardio-specificity of TCE as a teratogen and may reflect a requirement for normal calcium regulation of contractile function during organ development.
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Sneesby, Kyra. "Gene Expression in Embryonic Chick Heart Development." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367647.

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Establishment of the biochemical and molecular nature of cardiac development is essential for us to understand the relationship between genetic and morphological aspects of heart formation. The molecular mechanisms that underly heart development are still not clearly defined. To address this issue we have used two approaches to identify genes involved in early chick cardiac development. Differential display previously conducted in our laboratory led to the identification of two gene fragments differentially expressed in the heart that are further described in this thesis. The full-length cDNA sequence of both eukaryotic translation initiation factor-2b (eIF-2b) and NADH cytochrome b5 reductase (b5R) were isolated using library screening. The upreglation of these genes during heart development is expected given the heart is the first functional organ to form in vertebrates and protein synthesis and cell metabolism at this stage of development is maximal. Limitations in the differential display approach led to the development and optimisation of a subtractive hybridisation approach for use with small amounts of cells or tissue. To focus on cardiac gene expression during the initial phases of heart development, subtractive hybridization was performed between the cardiogenic lateral plate mesoderm of Hamburger and Hamilton stage 4 embryos and the heart primordia of stage 9 embryos. Of the 87 independent clones identified by this procedure, 59 matched known sequences with high homology, 25 matched unknown expressed sequence tag (EST) sequences with high homology, and 3 did not match any known sequence on the database. Known genes isolated included those involved in transcription, translation, cell signalling, RNA processing, and energy production. Two of these genes, high mobility group phosphoprotein A2 (HMGA2) and C1-20C, an unknown gene, were chosen for further characterisation. The role of each gene in early chick heart development and indeed development in general, was addressed using techniques such as in situ hybridisation, transfection analysis, in ovo electroporation and RNAi. HMGA2 is a nuclear phosphoprotein commonly referred to as an architectural transcription factor due to its ability to modulate DNA conformation. In keeping with this function, HMGA2/GFP fusion protein was shown to localise to the nucleus and in particular, the nucleolus. In situ hybridisation analysis suggested a role for HMGA2 in heart and somite development. HMGA2 expression was first detected at HH stage 5 in the lateral plate mesoderm, a region synonymous with cells specified to the cardiac fate. HMGA2 was also strongly expressed in the presomitic segmental plate mesoderm and as somites developed from the segmental plate mesoderm, the expression of HMGA2 showed an increasingly more restricted domain corresponding to the level of maturation of the somite. Restriction of HMGA2 expression was first detected in the dorsal region of the epithelial somite, then the dorsomedial lip of the dermomyotome, and finally the migrating epaxial myotome cells. The novel intronless gene, C1-20C, predicts a protein of 148 amino acids containing a putative zinc finger binding domain and prenyl binding motif. Zinc binding assays showed that the zinc finger domain of C1-20C/MBP fusion protein bound over six times the quantity of zinc compared to MBP alone, although not in a 1:1 stoichiometric molar ratio. C1-20C/GFP fusion protein was shown to localise to as yet unidentified intracellular cytoplasmic vesicular compartments. These compartments did not colocalise with the endosome/lysosome pathway, aparently ruling out a role for C1-20C in protein trafficking, recycling or degradation. Expression of C1-20C in the chick embryo suggests a possible role in heart and notochord development and preliminary results using siRNA suggest that C1-20C is involved in normal heart looping.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
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Books on the topic "Heart development"

1

Cardiac development. Oxford: Oxford University Press, 2006.

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Harvey, Richard P., and Nadia Rosenthal. Heart development and regeneration. Amsterdam: Academic, 2010.

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Cartwright, Elizabeth Jane. Gene expression during heart development. Manchester: University of Manchester, 1995.

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Foundation), Symposium on Development of the Cardiac Conduction System (2002 Novartis. Development of the cardiac conduction system. Chichester, UK: Wiley, 2003.

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Filipoiu, Florin Mihail. Atlas of Heart Anatomy and Development. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-5382-5.

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1930-, Sezai Yukiyasu, Barron J. Patrick, and Shiono Motomi, eds. Artificial heart, 1993: The development of biomation in the 21st century. Chur, Switzerland: Harwood Academic Publishers, 1993.

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Torrado, Mario. Shaping the Heart in Development and Disease. Kerala, India: Transword Research Network, 2010.

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Canada Economic Development for Quebec Regions. The agency at the heart of development. [Ottawa]: Canada Economic Development for Quebec Regions, 2003.

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Medina, Carlos R. Missionaries and development. Baguio City, Philippines: Saint Louis University, Cordillera Research and Development Foundation, 2004.

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Bock, Chan Chin, Ang Kong Hua, Singapore Economic Development Board, and EDB Society, eds. Heart work. Singapore: Singapore Economic Development Board and EDB Society, 2002.

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Book chapters on the topic "Heart development"

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Eberhart, Robert C., Chi-Chun Tsai, and Richard B. Timmons. "Biocompatible Material Development." In Heart Replacement, 15–28. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-67023-0_2.

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Wessels, Andy. "Inflow Tract Development." In Congenital Heart Diseases: The Broken Heart, 55–62. Vienna: Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2_5.

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Jensen, Bjarke, and Antoon F. M. Moorman. "Evolutionary Aspects of Cardiac Development." In Congenital Heart Diseases: The Broken Heart, 109–17. Vienna: Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2_10.

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Magrini, F. "Haemodynamic development." In The Heart in Hypertension, 27–35. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0941-0_4.

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Kijima, Toshihiko, Hiroaki Oshiyama, Kazuhiko Hagiwara, Kunio Horiuchi, Atsuhiko Nogawa, Hiroaki Hamasaki, Takayuki Kido, et al. "Development of Straight Path Centrifugal Pump." In Heart Replacement, 309–12. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-67023-0_43.

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Sedmera, David. "Hemodynamics During Development and Postnatal Life." In Congenital Heart Diseases: The Broken Heart, 97–107. Vienna: Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2_9.

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Radley, Alan. "Development of Theory." In Prospects of Heart Surgery, 183–99. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3874-4_8.

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Markwald, Roger R., and Andy Wessels. "Overview of Heart Development." In Formation of the Heart and Its Regulation, 1–22. Boston, MA: Birkhäuser Boston, 2001. http://dx.doi.org/10.1007/978-1-4612-0207-3_1.

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Isoyama, Takashi, Kou Imachi, Tsuneo Chinzei, Yuusuke Abe, Kunihiko Mabuchi, Kaoru Imanishi, Takumi Yonezawa, et al. "Development of a Pulsatile Total Artificial Heart Using a Single Continuous Flow Pump: Development of the Third Model." In Heart Replacement, 287–90. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-67023-0_38.

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Tatsumi, Eisuke, Yoshiyuki Taenaka, Toru Masuzawa, Wonwoo Choi, Koichi Toda, Koji Miyazaki, Takeshi Nakatani, et al. "Development of an Electrohydraulic Total Artificial Heart System." In Heart Replacement, 101–7. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-67020-9_11.

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Conference papers on the topic "Heart development"

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Rosenberg, David. "THE HEART OF THE MATTER." In International Technology, Education and Development Conference. IATED, 2017. http://dx.doi.org/10.21125/inted.2017.0980.

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Marom, Ronit, and Ion Albulescu. "The importance of a "heart-to-heart" conversation as part of emotional education in elementary schools." In ERD 2016 - Education, Reflection, Development, Fourth Edition. Cognitive-crcs, 2016. http://dx.doi.org/10.15405/epsbs.2016.12.43.

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Yousri, Nur Afifah, Nurul Usna Abd Rahman, and Nabilah Ibrahim. "Heart Sounds Frequency Analysis for Development of Auto Diagnosis System of Heart Disease." In 2022 IEEE 20th Student Conference on Research and Development (SCOReD). IEEE, 2022. http://dx.doi.org/10.1109/scored57082.2022.9974035.

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Bugtai, N. T., S. U. Chan-Siy, J. E. Chua, J. A. Flores, and J. L. Wang. "Development of a Portable Heart Monitoring System." In TENCON 2012 - 2012 IEEE Region 10 Conference. IEEE, 2012. http://dx.doi.org/10.1109/tencon.2012.6412248.

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Tiwari, Hemant Kumar, and Ashish Harsola. "Development of embedded stethoscope for Heart Sound." In 2016 International Conference on Wireless Communications, Signal Processing and Networking (WiSPNET). IEEE, 2016. http://dx.doi.org/10.1109/wispnet.2016.7566396.

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Ferreira, Renan Yuji Koga, Guilherme Camargo Fabricio De Melloy, Fabio Sakurayz, and Wesley Attrot. "Software System Development to Diagnose Heart Diseases." In Congresso Latino-Americano de Software Livre e Tecnologias Abertas. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/latinoware.2019.10353.

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Many deaths are caused from heart diseases and several of them could be prevented with early detection. Many people do not have conditions to seek for a doctor or sometimes there are not enough physicians to attend them. In order to detect heart diseases we are developing an electrocardiogram feature extraction algorithm using wavelet transforms prioritizing a low computational cost. This algorithm will be integrated in an embedded system that is under development. This system is going to be accessible, portable and have low cost, because we intend to assist people, mostly those who live in precarious regions, that do not have a physician to attend them. To execute tests on our algorithm we will use the ECG records from MITBIH database and after that we will classify the heartbeats in order to detect anomalies on them.
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Liu, Zhenyi. "The Development Prospects of Heart Rate Monitor." In 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022). Paris, France: Atlantis Press, 2022. http://dx.doi.org/10.2991/aebmr.k.220404.066.

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Shaikh, Sana, Amit Sawant, Shreerang Paradkar, and Kedar Patil. "Electronic recording system-heart disease prediction system." In 2015 International Conference on Technologies for Sustainable Development (ICTSD). IEEE, 2015. http://dx.doi.org/10.1109/ictsd.2015.7095854.

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ZEWDIE, Retta, and Pavel KIC. "ANALYSIS OF PRINCIPAL STRESS FACTORS AFFECTING DRIVERS IN DIFFERENT VEHICLES." In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.090.

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The aim of this research paper is to compare the effect of the heart rate variabilities on different vehicle drivers. The most common urban transport vehicles (bus, tram and metro) are compared with typical mobile agricultural machines (tractors and combine harvesters) and passenger car. The measurements were focused on the complexity and traffic routes, velocities of each vehicle and ages of drivers related to changes in the heart rate of drivers as main parameters. The authors characterize cardinal factors affecting the contentment of drivers while undertaking their performance. The results of the measurements showed that the lowest mean heart rate value was registered on metro (subway car) drivers scoring 59 bpm, whereas the bus drivers 80 bpm and tram 77 bpm. The mean heart rate value of the combine harvester drivers scored 106 bpm and tractor drivers 108 bpm, which indicates that the driver’s heart rate of the agricultural machineries were significantly greater. The heart rate of tram drivers has increased significantly in a short period of time by 75%, metro (subway) drivers by 59%, combine harvester drivers by 23% and tractor drivers by 19%, whereas the passenger car drivers’ heart rate value increase was by 30%. The driving velocity, drivers’ age and weight showed its effect on the heart rate variabilities. The data collections were made by a heart rate measurement device. Relevant data on technical conditions stretch and shape design routes; as well as the heart rate variabilities on the respective drivers are collected carefully for detail statistical analysis.
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Narayanan, S. Nambi, S. Sutha, and G. Divya. "Development of non-linear model for human heart." In 2017 Trends in Industrial Measurement and Automation (TIMA). IEEE, 2017. http://dx.doi.org/10.1109/tima.2017.8064818.

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Reports on the topic "Heart development"

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Paxton, Christian N., and James M. Reecy. Identifying a Role for Tbx2 in Heart Development. Ames (Iowa): Iowa State University, January 2004. http://dx.doi.org/10.31274/ans_air-180814-63.

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Veilleux, Richard, and David Levy. Potato Germplasm Development for Warm Climates. United States Department of Agriculture, October 1992. http://dx.doi.org/10.32747/1992.7561057.bard.

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Complex potato hybrids derived from crosses between cv. Atlantic and 11 clones of three genomic compositions, all with an unadapted component from previously identified heat tolerant accessions, were evaluated in the field in Israel and Virginia and in controlled environments in Israel. Heat tolerance was exhibited in the field by the ability of many of these hybrids to tuberize under severe heat stress when cv. Atlantic did not tuberize at all. The complex hybrids also exhibited fewer internal defects (heat necrosis, hollow heart) than Atlantic. Studies to determine if heat stress applied during anther culture or to pollen samples prior to pollination could affect gametic selection towards more heat tolerant progenies were also undertaken. There was some evidence of greater heat tolerance (longer survival under heat stress) in the anther-derived population that had been regenerated under heat stress. The seedlings resulting from crosses with heat-treated pollen also exhibited greater haulm growth under heat stress compared with controls. However, the poor adaption of the germplasm prevented a firm conclusion about gametic selection. The introduction of exotic germplasm into cultivated potato has considerable potential to adapt potato to nontraditional growing seasons and climates. However, such hybrids will require continued selection and evaluation to retain the traits required for commercial production.
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Gist, Ryan. Heart of the Hearth: Making the Popular Clean, Not the Clean Popular - Technology Research, Development, and Tools for Clean Biomass Cookstoves. Office of Scientific and Technical Information (OSTI), December 2016. http://dx.doi.org/10.2172/1337926.

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Georgitsis, Micheal. The Effect of Lymph Sac Pressure on Lymph Heart Pressure Development in the Toad Bufo Marinus. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.7232.

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Johnson, Eric M., and Robert Chew. Social Network Analysis Methods for International Development. RTI Press, May 2021. http://dx.doi.org/10.3768/rtipress.2021.rb.0026.2105.

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Social Network Analysis (SNA) is a promising yet underutilized tool in the international development field. SNA entails collecting and analyzing data to characterize and visualize social networks, where nodes represent network members and edges connecting nodes represent relationships or exchanges among them. SNA can help both researchers and practitioners understand the social, political, and economic relational dynamics at the heart of international development programming. It can inform program design, monitoring, and evaluation to answer questions related to where people get information; with whom goods and services are exchanged; who people value, trust, or respect; who has power and influence and who is excluded; and how these dynamics change over time. This brief advances the case for use of SNA in international development, outlines general approaches, and discusses two recently conducted case studies that illustrate its potential. It concludes with recommendations for how to increase SNA use in international development.
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Wong, Debbie, and Elizabeth Cassity. . Teacher development multi-year studies. Emerging themes: Challenges and enablers. Australian Council for Educational Research, 2021. http://dx.doi.org/10.37517/978-1-74286-675-8.

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The global learning crisis has highlighted the urgent need to improve the quality of education. COVID-19 disruptions have placed even greater focus on the learning improvement agenda, and the need to ensure disadvantaged children are not further left behind. Teacher development, and improving teaching quality, therefore is at the heart of many education systems’ policies and programs. This paper presents some of the key considerations for improving teaching across three countries which are being investigated as part of a multi-year teacher development study series. This study series, commissioned by the Australian Government’s Department of Foreign Affairs and Trade (DFAT), involves the investigation of teacher development initiatives in Timor-Leste, Vanuatu and Lao People’s Democratic Republic (Laos). The overall aim of each study is to investigate: To what extent does the Australian investment produce improved teaching quality and improved student learning?
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Brosh, Arieh, David Robertshaw, Yoav Aharoni, Zvi Holzer, Mario Gutman, and Amichai Arieli. Estimation of Energy Expenditure of Free Living and Growing Domesticated Ruminants by Heart Rate Measurement. United States Department of Agriculture, April 2002. http://dx.doi.org/10.32747/2002.7580685.bard.

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Research objectives were: 1) To study the effect of diet energy density, level of exercise, thermal conditions and reproductive state on cardiovascular function as it relates to oxygen (O2) mobilization. 2) To validate the use of heart rate (HR) to predict energy expenditure (EE) of ruminants, by measuring and calculating the energy balance components at different productive and reproductive states. 3) To validate the use of HR to identify changes in the metabolizable energy (ME) and ME intake (MEI) of grazing ruminants. Background: The development of an effective method for the measurement of EE is essential for understanding the management of both grazing and confined feedlot animals. The use of HR as a method of estimating EE in free-ranging large ruminants has been limited by the availability of suitable field monitoring equipment and by the absence of empirical understanding of the relationship between cardiac function and metabolic rate. Recent developments in microelectronics provide a good opportunity to use small HR devices to monitor free-range animals. The estimation of O2 uptake (VO2) of animals from their HR has to be based upon a consistent relationship between HR and VO2. The question as to whether, or to what extent, feeding level, environmental conditions and reproductive state affect such a relationship is still unanswered. Studies on the basic physiology of O2 mobilization (in USA) and field and feedlot-based investigations (in Israel) covered a , variety of conditions in order to investigate the possibilities of using HR to estimate EE. In USA the physiological studies conducted using animals with implanted flow probes, show that: I) although stroke volume decreases during intense exercise, VO2 per one heart beat per kgBW0.75 (O2 Pulse, O2P) actually increases and measurement of EE by HR and constant O2P may underestimate VO2unless the slope of the regression relating to heart rate and VO2 is also determined, 2) alterations in VO2 associated with the level of feeding and the effects of feeding itself have no effect on O2P, 3) both pregnancy and lactation may increase blood volume, especially lactation; but they have no effect on O2P, 4) ambient temperature in the range of 15 to 25°C in the resting animal has no effect on O2P, and 5) severe heat stress, induced by exercise, elevates body temperature to a sufficient extent that 14% of cardiac output may be required to dissipate the heat generated by exercise rather than for O2 transport. However, this is an unusual situation and its affect on EE estimation in a freely grazing animal, especially when heart rate is monitored over several days, is minor. In Israel three experiments were carried out in the hot summer to define changes in O2P attributable to changes in the time of day or In the heat load. The animals used were lambs and young calves in the growing phase and highly yielding dairy cows. In the growing animals the time of day, or the heat load, affected HR and VO2, but had no effect on O2P. On the other hand, the O2P measured in lactating cows was affected by the heat load; this is similar to the finding in the USA study of sheep. Energy balance trials were conducted to compare MEI recovery by the retained energy (RE) and by EE as measured by HR and O2P. The trial hypothesis was that if HR reliably estimated EE, the MEI proportion to (EE+RE) would not be significantly different from 1.0. Beef cows along a year of their reproductive cycle and growing lambs were used. The MEI recoveries of both trials were not significantly different from 1.0, 1.062+0.026 and 0.957+0.024 respectively. The cows' reproductive state did not affect the O2P, which is similar to the finding in the USA study. Pasture ME content and animal variables such as HR, VO2, O2P and EE of cows on grazing and in confinement were measured throughout three years under twenty-nine combinations of herbage quality and cows' reproductive state. In twelve grazing states, individual faecal output (FO) was measured and MEI was calculated. Regression analyses of the EE and RE dependent on MEI were highly significant (P<0.001). The predicted values of EE at zero intake (78 kcal/kgBW0.75), were similar to those estimated by NRC (1984). The EE at maintenance condition of the grazing cows (EE=MEI, 125 kcal/kgBW0.75) which are in the range of 96.1 to 125.5 as presented by NRC (1996 pp 6-7) for beef cows. Average daily HR and EE were significantly increased by lactation, P<0.001 and P<0.02 respectively. Grazing ME significantly increased HR and EE, P<0.001 and P<0.00l respectively. In contradiction to the finding in confined ewes and cows, the O2P of the grazing cows was significantly affected by the combined treatments (P<0.00l ); this effect was significantly related to the diet ME (P<0.00l ) and consequently to the MEI (P<0.03). Grazing significantly increased O2P compared to confinement. So, when EE of grazing animals during a certain season of the year is estimated using the HR method, the O2P must be re measured whenever grazing ME changes. A high correlation (R2>0.96) of group average EE and of HR dependency on MEI was also found in confined cows, which were fed six different diets and in growing lambs on three diets. In conclusion, the studies conducted in USA and in Israel investigated in depth the physiological mechanisms of cardiovascular and O2 mobilization, and went on to investigate a wide variety of ruminant species, ages, reproductive states, diets ME, time of intake and time of day, and compared these variables under grazing and confinement conditions. From these combined studies we can conclude that EE can be determined from HR measurements during several days, multiplied by O2P measured over a short period of time (10-15 min). The study showed that RE could be determined during the growing phase without slaughtering. In the near future the development microelectronic devices will enable wide use of the HR method to determine EE and energy balance. It will open new scopes of physiological and agricultural research with minimizes strain on animals. The method also has a high potential as a tool for herd management.
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Uzelac, Sarah. Incoherent at Heart: The EU’s economic and migration policies towards North Africa. Oxfam, November 2020. http://dx.doi.org/10.21201/2020.6805.

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Pre-pandemic, EU policies towards North Africa, especially Tunisia and Morocco, focused on two main paradigms: trade liberalization and the minimization of both regular and irregular migration. These agendas were incoherent and had overwhelmingly negative implications for the livelihoods and employment opportunities within the EU for the most vulnerable people in the Maghreb. As the coronavirus impacts continue to wreak havoc on world economies, any future negotiations on the Deep and Comprehensive Free Trade Areas (DCFTAs) ought to be geared towards supporting fair and inclusive recovery in North Africa based on reducing inequality and promoting shared prosperity and development.
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Barnes, Katrina, Barnes, Katrina, Colin Anderson, Stephanie de Chassy, Affaf Ahmed, Mudabbir Ali, Myo Min Aung, Egidio Chaimite, et al. Understanding Governance from the Margins: What Does It Mean In Practice? Institute of Development Studies (IDS), November 2021. http://dx.doi.org/10.19088/a4ea.2021.003.

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What does governance look like ‘from below’ – from the perspectives of poor and marginalised households? How do patterns of conflict affect that? These were the questions at the heart of the Governance at the Margins research project. Over three years from 2017-2020 we worked to explore this through in-depth study in conflict-affected areas of Mozambique, Myanmar, and Pakistan. Our research teams interviewed the same people regularly over that time, finding out how they resolved problems and interacted with authorities. In this paper we connect what we found to the realities and complexities of development practice, drawing on the input of 20 experienced practitioners working in bilateral and multilateral development agencies and international NGOs, who generously gave their time to help us think through the practical implications of our wealth of findings.
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Hossain, Niamat Ullah Ibne, Farjana Nur, Raed Jaradat, Seyedmohsen Hosseini, Mohammad Marufuzzaman, Stephen Puryear, and Randy Buchanan. Metrics for assessing overall performance of inland waterway ports : a Bayesian Network based approach. Engineer Research and Development Center (U.S.), May 2021. http://dx.doi.org/10.21079/11681/40545.

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Because ports are considered to be the heart of the maritime transportation system, thereby assessing port performance is necessary for a nation’s development and economic success. This study proposes a novel metric, namely, “port performance index (PPI)”, to determine the overall performance and utilization of inland waterway ports based on six criteria, port facility, port availability, port economics, port service, port connectivity, and port environment. Unlike existing literature, which mainly ranks ports based on quantitative factors, this study utilizes a Bayesian Network (BN) model that focuses on both quantitative and qualitative factors to rank a port. The assessment of inland waterway port performance is further analyzed based on different advanced techniques such as sensitivity analysis and belief propagation. Insights drawn from the study show that all the six criteria are necessary to predict PPI. The study also showed that port service has the highest impact while port economics has the lowest impact among the six criteria on PPI for inland waterway ports.
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