Dissertations / Theses on the topic 'Heart cells Molecular aspects'
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Huang, Zheng. "Molecular physiology of Cl.ir [sic] channels in the heart." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3312252.
Full textKojima, Kiyohide. "Molecular Aspects of the Plasma Membrane in Tumor Cells." 名古屋大学医学部, 1993. http://hdl.handle.net/2237/6164.
Full textCarlsson, Lennart. "Aspects of interferon alpha signalling in hematopoetic cells." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-318.
Full textMakubalo, Zola. "Mutation screening of candidate genes and the development of polymorphic markers residing on chromosome 19q13.3, the progressive familial heart block I gene search area." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51838.
Full textENGLISH ABSTRACT: Progressive familial heart block type I (PFHBI) is a cardiac ventricular conduction disorder of unknown cause associated with risk of sudden death, which has been described in several South African families. Clinically, PFHBI is characterised by right bundle branch block on ECG, which may progress to complete heart block, necessitating pacemaker implantation. The disease shows an autosomal dominant pattern of inheritance with evidence of genetic anticipation. Using genetic linkage analysis, the PFHBI-causative gene was mapped to a 10 eentimorgan (cM) gene-rich area of chromosome (C) 19q13.3, which has, subsequently, been reduced to 7cM by fine mapping with polymorphic dinucleotide (CA)n short tandem repeat (STR) markers. Several attractive candidate genes, including muscle glycogen synthase (GSY 1) and histidine-rich calcium binding protein (HRC), lie within this region. The aim of the present study was two-fold: 1) to identify and characterise tetranucleotide (AAAT)n STRs within the PFHBI critical region that could be developed as polymorphic markers for use in genetic fine mapping and 2) to screen selected regions of GSY 1and HRC, positional candidate genes, for the presence ofPFHBI-causing mutation(s). Cosmids harbouring CI9q13.3 insert DNA were screened for the presence of (AAAT)n STRs by dot blot and Southern blot hybridisation using a radiolabelled (AAAT)lO oligonucleotide probe. To characterise the harboured (AAAT)n STRs, the positively hybridising fragments identified by Southern blot were sub-cloned, sequenced and primers designed from the unique repeat-flanking sequences. These primers were used to genotype the (AAAT)n repeat locus to assess its polymorphic nature in a panel of unrelated individuals. Alternatively, vectorette PCR, a rapid method of identifying repeat sequences and obtaining the flanking sequences in large inserts, was employed to develop polymorphic markers from the positively hybridising clones. Selected exons of GSY1 and HRC were screened for the presence of potentially disease-causing mutations by PCR-SSCP analysis and direct sequencing, respectively, in PFHBI-affected and unaffected family members. Of the available cosmid clones that gave strong signals on dot blot and Southern blot hybridisation, three, 29395, 24493 and 20381, were located within the critical PFHBI area and were used for marker development. An interrupted (AAAT)n repeat motif (n less than 5) was identified in cosmid 29395, however, the repeat locus was not polymorphic in the tested population. No (AAAT)n motif, single or repeated was observed in the partial sequence of the sub-cloned fragment of cosmid 24493. Using vectorette peR, no repeated (AAAT)n motif was identified on sequencing the generated products in either cosmid 24493 or 2038l. However, diffuse single AAAT motifs were detected in both cosmids. Exons 4, 5, 11, 12 and 16 of GSY 1, containing domains that are conserved across species, and the conserved eterminus- encoding exons 2-6 of HRC were selected for screening for potential PFHBI-causing mutation(s). However, no sequence variations were detected. The interrupted (AAAT)n repeat identified in cosmid 29395 was not polymorphic, which confirmed reports that complex repeats, especially those containing AAAT motifs of less than 6 repeats, are not polymorphic. One possible explanation for the absence of a repeated AAAT motif in cosmids 24493 and 20381, which both gave positive hybridisation signals, is that the low annealing temperature of the AfT -rich repeat-anchored primers used in vectorette peR may have resulted in transient annealing to the diffuse single AAAT motifs detected on sequencing. The screened regions of candidate genes GSYI and HRC were excluded from carrying the disease-causing mutation(s). The availability of new sequence data generated by the Human Genome Project will influence future strategies to identify the PFHBI gene. Electronic searches will allow identification of STR sequences for development of polymorphic markers and gene annotation will allow selection of new candidate genes for mutation screening.
AFRIKAANSE OPSOMMING: Sien volteks vir opsomming
Dormans-Linssen, Maria Caroline Jacqueline Gerarda. "Cells of adult rat heart isolation, characterization and some aspects of fatty acid metabolism /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5959.
Full textDahlenborg, Katarina. "Celluar and molecular aspects of the germinal center reaction." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945013.html.
Full textCheng, Yin-wo, and 鄭燕和. "Molecular basis for the increased osteoblast activity in a mouse modelwith hyperostosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34612981.
Full textLee, Yuk-kwan Mary, and 李玉筠. "Molecular changes in regenerated and senescent cultured endothelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38765512.
Full textZhian, Samaneh. "Molecular Genetic Analysis of CRELD1 in Patients with Heterotaxy Disorder." PDXScholar, 2011. https://pdxscholar.library.pdx.edu/open_access_etds/410.
Full textPowell, Alexander. "Molecules, cells and minds : aspects of bioscientific explanation." Thesis, University of Exeter, 2009. http://hdl.handle.net/10036/95416.
Full textYang, Min, and 杨敏. "Role of regulatory B cells in autoimmune disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079832.
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Pathology
Doctoral
Doctor of Philosophy
Lai, King-yin, and 賴景然. "Cloning and characterization of the demilune cells and parotid protein(Dcpp) gene promoter." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010821.
Full textSze, Ivan, and 施綺雯. "Estrogenic effects of isoflavonoids on human breast cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010894.
Full textVessey, S. J. R. "A molecular analysis of the T-cell receptor." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:87b560f9-b1d6-4b12-9c94-fd1b4de397f6.
Full textWang, Hui. "Molecular mechanisms of oridonin-induced cytotoxicity and apoptosis in HepG2 cells." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1162.
Full text陳遠雯 and Yun-wen Wendy Chen. "Molecular genetics of gastric non-Hodgkin's B-cell lymphomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3124404X.
Full textNie, Yingjie, and 聶瑛潔. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells ascell-therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278681.
Full textLiu, Yang, and 劉洋. "The role of regulatory B cells in the development of autoimmune diabetes in NOD mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197509.
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Pathology
Master
Master of Philosophy
Zhang, Hao, and 張浩. "Cytogenetic and molecular alterations in immortalization of normal esophageal epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32047010.
Full textWong, Kit-man Sunny, and 王傑民. "Isolation and characterization of cancer stem cells in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47250665.
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Pathology
Master
Master of Philosophy
Sun, Qian, and 孫倩. "Cellular and molecular mechanisms of dendritic cell differentiation from cells of leukaemic origin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38885335.
Full textGustafsson, Åke. "Functional and molecular aspects of interferon action in human natural killer cells and other leucocytes." Doctoral thesis, Umeå universitet, Virologi, 1985. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-99342.
Full textDiss. (sammanfattning) Umeå : Umeå universitet, 1985, härtill 5 uppsatser.
digitalisering@umu
Wescott, David Clark, and n/a. "Osteogenic gene expression by human periodontal ligament cells under cyclic mechanical tension." University of Otago. School of Dentistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081202.131453.
Full textMaliken, Bryan D. B. A. "Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535375861364685.
Full textLi, Jing, and 李靜. "Effects of intrinsic & extrinsic factors on the growth and differentiation of human mesenchymal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37238310.
Full textAnstine, Lindsey J. "Valve cell dynamics in developing, mature, and aging heart valves." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1478692972995079.
Full textSchnetzer, Karen Joan. "Effects of in vitro uniaxial cyclic stretch upon rat aortic smooth muscle cells." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/10236.
Full textHui, Wing-sum, and 許永森. "Molecular and mutation analysis of hereditary multiple exostoses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42577081.
Full textZhou, Li, and 周莉. "The molecular mechanisms of aristolochic acid nephropathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224349.
Full textCastellanos, Glenda L. "Cellular Events Under Flow States Pertinent to Heart Valve Function." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2285.
Full textCheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.
Full textScharner, Juergen. "Defective adult muscle satellite cells in Zmpste24 deficient mice." Thesis, Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508269.
Full textWarner, Anke Sigrid. "The expression, regulation and effects of inducible nitric oxide synthase in hibernating myocardium." Title page, contents and summary only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phw279.pdf.
Full textZhou, Shuangcheng, and 周雙宬. "Defects in early B lymphocyte development in Zmpste24⁻′⁻ mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43703641.
Full textChan, Yuen-fan, and 陳婉芬. "Adrenomedullin in the rat testis: its production, functions and regulation in sertoli cells and leydig cellsand its interaction with endothelin-1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37448341.
Full textLam, Shuk-pik, and 林淑碧. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085647.
Full textChan, Kwok-kin, and 陳國堅. "In vivo study on cell cycle and checkpoint regulation during mouse liver development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4559000X.
Full textBurke, Paula Louise, and University of Lethbridge Faculty of Arts and Science. "The oligomeric state of archaeal fibrillarin : implications in the organization and function of essential box C/D sRNP particles." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/540.
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Lewandowski, Sara L. "Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/883.
Full textLewandowski, Sara L. "Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/883.
Full textPinkerton, Mark Neil, and n/a. "The molecular basis of orthodontic tooth movement : cytokine signaling by PDL cells in tension an in vitro study." University of Otago. School of Dentistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071207.161056.
Full textLim, Ai Ing, and 林艾盈. "Shedding of kidney injury molecule-1 by kidney proximal tubular epithelial cells: the role of matrixmetalloproteinase-3." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49799745.
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Medicine
Master
Master of Philosophy
Pang, Bo, and 龐博. "Antiproliferative actions of melatonin and secreted PDZ domain-containing protein 2 (sPDZD2) on tumor cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224064.
Full textGlinsmann-Gibson, Betty Jean 1961. "Molecular mechanism of autocrine regulation by TGF-alpha in T(3)M(4) human pancreatic carcinoma cells." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277113.
Full textLee, Lai-sheung, and 李麗裳. "Characterization of arsenic transformed rat lung epithelial cells (TLECs) by biochemical and proteomic approaches." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085283.
Full textAndrews, Daniel Mark. "Effects of murine cytomegalovirus infection on dendritic cell functionality and natural killer cell responses." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0003.
Full textLeung, Chun-to, and 梁鎮濤. "Cellular and molecular characterization of mammary tumor development in wild type and adiponectin deficient MMTV-PyVT mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50712640.
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Pharmacology and Pharmacy
Master
Master of Medical Sciences
Au, Wing-yan, and 區永仁. "Pathogenesis and progression of malignant B cell neoplasms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45007676.
Full textEfstathiou, Jason Alexander. "The role of adhesion molecules in colorectal carcinogenesis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670210.
Full textTeoh, Kim Tat, and 張錦達. "The E envelope protein of the SARS coronavirus interacts with the pals1 tight junction protein through its PDZ domain: consequences for polarity of infected epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43913210.
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