Journal articles on the topic 'Health Status Indications'
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Jonas, Richard A. "Deep hypothermic circulatory arrest: Current status and indications." Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual 5, no. 1 (January 2002): 76–88. http://dx.doi.org/10.1053/pcsu.2002.31493.
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Thool, Ketki N., Shuchi M. Jain, Poonam V. Shivkumar, Manish A. Jain, and Manjiri R. Podder. "A clinical audit and confidential enquiry of caesarean section indications at rural tertiary health care centre." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 4 (March 30, 2017): 1478. http://dx.doi.org/10.18203/10.18203/2320-1770.ijrcog20171413.
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Background: Worldwide CSR has been steadily increasing beyond recommended level of 15 %by WHO. High CSR have been reported in developed and developing countries. Reasons for increase in CSR are not obvious and somewhat complex. Thus, present study was undertaken to analyze various indications for CS performed at rural tertiary health care centre Sewagram, M.S.Methods: This was prospective study included all women who underwent CS from 1st January 2015 till 30th June 2016. Data was entered in MS excel sheet analyzed with percentage and chi square test using SPSS ver.17.Results: CSR was 36 .88% in present study. As per NICE guidelines CS were classified in four categories based on urgency, women were distributed in each category. Category I had 22.62%, category II -38.61%, category III - 28.37% and Category IV - 10.40% women. In CAT I common indication was foetal bradycardia (71.53%). In CAT II CS, common indication was non reassuring foetal status (38.82%). Breech presentation (14.74%) and previous scar with doubtfull scar integrity (14.33) were next common indications. In CAT III (43.43%), IV (41.13%) previous LSCS with inadequate pelvis was the common indication. Confidential enquiry revealed that 26.17% (28/107), 20.3% (40/197), 23.17%, (35/151) and 8.3 % (5/60) of CAT I, II, III and IV CS had questionable indications.Conclusions: In this study, CSR was higher than WHO standard. Common indications in primipara was foetal distress while in multiparas primary indication previous LSCS
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La, Jennifer, David Cheng, Mary T. Brophy, Nhan V. Do, Jerry S. H. Lee, David Tuck, and Nathanael R. Fillmore. "Real-World Outcomes for Patients Treated With Immune Checkpoint Inhibitors in the Veterans Affairs System." JCO Clinical Cancer Informatics, no. 4 (October 2020): 918–28. http://dx.doi.org/10.1200/cci.20.00084.
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PURPOSE Increasingly broad patient groups are being treated with immune checkpoint inhibitors (ICIs) in clinical practice, but few studies have assessed their usage and outcomes in large, comprehensive real-world cohorts. We identified patients who received ICIs in the Veterans Affairs (VA) health care system and described patient characteristics and survival outcomes across multiple indications. METHODS We conducted a retrospective analysis using electronic health record data from VA facilities nationwide. Overall survival (OS) from time of ICI initiation for key indications was estimated by Kaplan-Meier. We also stratified OS by frailty status, as defined by a surrogate index developed in VA data. For select indications, we further compared outcomes to historic and concurrent control patients treated with standard-of-care regimens at the VA. RESULTS We identified 11,888 patients who were treated with ICIs and determined the cancer type and indication for which they were treated. The cohort is enriched for patient groups that are under-represented in pivotal clinical trials (PCTs), including older, non-White, and/or higher disease burdened patients. Generally, OS observed in the VA cohort is lower than that reported in PCTs. After stratifying VA patients by frailty status, OS among nonfrail patients is more similar to OS reported in PCTs for some indications. Compared with internal VA control cohorts, patients treated with ICIs generally exhibited longer OS for all indications considered. CONCLUSION This study describes ICI outcomes across multiple tumor types in a real-world population at the VA. For most indications, real-world survival outcomes are observed to be lower than those reported in PCTs, but patients receiving ICIs still achieve longer survival relative to patients receiving standard of care.
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Khursheed, Farkhunda, Sabrina Abbas, Chandra Madhudas, Zakia Zaheen, Nargis Bano, and Rashida Akbar. "Emergency Obstetrics Hysterectomy: Current Situation in a Tertiary care Hospital of Sindh." Pakistan Journal of Medical and Health Sciences 16, no. 2 (February 26, 2022): 1224–26. http://dx.doi.org/10.53350/pjmhs221621224.
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Objective: To determine the indications of emergency obstetrics hysterectomy (EOH) as a current situation in a tertiary care Hospital of Sindh. Material and Methods: This descriptive cross-sectional study was conducted at obstetrics and Gynaecology department of Liaquat University of Medical and Health Sciences. The study duration was one year from January 2021 to December 2021. All the women underwent emergency obstetric hysterectomies, aged 18 to 40 years, both multi and primiparous of either residential status or booking status were included. Hysterectomy conducted for bleeding unresponsive to conservative medical and surgical treatment at the time of cesarean section or after birth until 42 days postpartum was characterized as obstetric hysterectomy. Patients were assessed regarding indications of the emergency obstetrics hysterectomies. All the data were collected via self-made study proforma. SPSS version 26 was used for the analysis of data. Results: A total of 20 women were studied to assess the indications of emergency obstetrics hysterectomies. The average age of the women was 31.70+3.80 years and mean gestational age was 36.0+2.58 weeks. Placenta previa + morbidly adherent placenta was the most common indication 8(40.0%) with positive history of previous c-sections, uterine rupture was in 06(30.0%) women and placenta previa type IV was 03(15.0%), followed by fibroid uterus with history previous 3 c-sections was 01(5.0%), incomplete mischarge was 01(5.0%) and uterine atony was 01(5.0%). Indications were statistically insignificant according to residential status (p->0.05), while statistically significant according to booking status and parity (p-<0.05). Conclusion: As per current scenario the placenta previa+ morbidly adherent placenta (MAP) with history of multiple previous C-sections and rupture of the uterus were observed to be the frequently prevalent indications of emergency obstetrics hysterectomy. Women who have had past C-sections should receive comprehensive antenatal care. Keywords: Indications, EOH, morbidly adherent placenta, previous C-section
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Tran, KT, JM Stephens, KF Gold, A. Kimura, and CL Pashos. "PMD31: ASSESSING FUNCTIONAL STATUS IN CHILDREN: A REVIEW OF THE CHILDHOOD HAQ FOR NON-ARTHRITIS INDICATIONS." Value in Health 6, no. 3 (May 2003): 303. http://dx.doi.org/10.1016/s1098-3015(10)64109-5.
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Kuper, Spencer, Robin Steele, Rachel Sievert, Alan Tita, Lorie Harper, and Michelle Wang. "Outcomes of Medically Indicated Preterm Births Differ by Indication." American Journal of Perinatology 35, no. 08 (December 29, 2017): 758–63. http://dx.doi.org/10.1055/s-0037-1615792.
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Objective We aim to examine whether outcomes of preterm birth (PTB) are further modified by the indication for delivery. Study Design We performed a retrospective cohort study of all singletons delivered at 23 to 34 weeks from 2011 to 2014. Women were classified by their primary indication for delivery: maternal (preeclampsia) or fetal/obstetric (growth restriction, nonreassuring fetal status, and vaginal bleeding). The primary neonatal outcome was a composite of neonatal death, cord pH <7 or base excess < − 12, 5-minute Apgar ≤3, C-reactive protein during resuscitation, culture-proven sepsis, intraventricular hemorrhage, and necrotizing enterocolitis. Secondary outcomes included the individual components of the primary outcome. Groups were compared using Student's t-test and chi-squared tests. Logistic regression was used to adjust for confounding variables. Results Of 528 women, 395 (74.8%) were delivered for maternal and 133 (25.2%) for fetal/obstetric indications. Compared with those delivered for a maternal indication, those with a fetal/obstetric indication for delivery had an increased risk of the composite neonatal outcome (adjusted odds ratio [AOR]: 1.9, 95% confidence interval [CI]: 1.13–3.21) and acidemia at birth (AOR: 4.2, 95% CI: 1.89–9.55). Conclusion Preterm infants delivered for fetal/obstetric indications have worsened outcomes compared with those delivered for maternal indications. Additional research is needed to further tailor counseling specific to the indication for delivery.
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Khatun, Asma, Tahmina Khatun, Shahinur Rahman, Mst Sharifa Khatun, Kazi Khadeza Farhin, Rahima Sultana, Md Habibur Rahman, Nazneen Rahman, Farhana Hyder Chowdhury, and Asma Sharmin. "Indications and Outcomes of Maternal and Neonatal Health among Emergency Cesarean Section- a Retrospective Study." East African Scholars Journal of Medical Sciences 6, no. 12 (December 9, 2023): 388–92. http://dx.doi.org/10.36349/easms.2023.v06i12.002.
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Introduction: The rate of cesarean sections is rising globally, with varying indications and outcomes. This study aims to analyze the indications and outcomes of emergency cesarean sections in a Bangladeshi context, focusing on maternal and neonatal health. Methods: This retrospective observational study was conducted at Netrokona Medical College, Bangladesh, from July 2021 to June 2022. It included 100 cases of emergency cesarean sections, excluding elective cases and those with incomplete records. Data on maternal age, gravidity, socioeconomic status, gestational age, BMI, indications for cesarean section, and maternal and neonatal outcomes were collected and analyzed. Result: The majority of cesarean sections were performed on women aged 21-30 (67%). The most common indication was a previous cesarean section (42%), followed by fetal distress (16%) and placenta previa (11%). Maternal outcomes showed 82% of women had no complications, with fever (12%) and excessive blood loss (8%) being the most common issues. Neonatal outcomes were generally positive, with 97% having APGAR scores ≥7. The gender distribution was 59% male and 41% female, and most neonates had normal or healthy birth weights. Conclusion: The study highlights a high prevalence of emergency cesarean sections among younger women, primarily due to previous cesarean sections. While maternal and neonatal outcomes were largely favorable, the presence of postoperative complications indicates the need for enhanced care. These findings underscore the importance of careful assessment in emergency cesarean sections and postoperative monitoring, particularly in resource-limited settings like Bangladesh.
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Norström, Elin, Rudolf Gustavsson, Fredrik Molin, and Sara Gummesson. "Micro-fossil analysis of Mesolithic human dental calculus, Motala, Sweden - Indications of health status and paleo-diet." Journal of Archaeological Science: Reports 26 (August 2019): 101866. http://dx.doi.org/10.1016/j.jasrep.2019.05.031.
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Walker, Judi, and Grant Lennox. "Duelling Band-aids: Debating and Debunking Issues Affecting Primary Health Care to Achieve Deliverance for Australia's Health." Australian Journal of Primary Health 6, no. 4 (2000): 147. http://dx.doi.org/10.1071/py00048.
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The constant pressure for growth on all areas of health spending is not matched by the country's capacity to pay. Despite a progressive shift to a primary health care approach that promotes health and wellbeing, illness prevention, healthy lifestyles, early detection, rehabilitation and public health strategies, not all segments of Australian society enjoy good health. In this paper, general indications of the health and wellbeing of Australians are described, and the health and wellbeing of two important population groups: rural and remote and Indigenous populations are discussed, providing a review of Australia's health system. Anomalies in the status of the health of Australians are apparent. Models of primary healthcare, individual health and urban health are compared with models of acute and institutional care, population health and rural health.
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Jang, In-Woo, Ji-Eun Chang, Jongyoon Kim, and Kiyon Rhew. "Status of Medications Prescribed for Psychiatric Disorders in Korean Pediatric and Adolescent Patients." Children 9, no. 1 (January 5, 2022): 68. http://dx.doi.org/10.3390/children9010068.
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While mental health services for children are increasing, few psychiatric drugs have been approved for such use. We analyzed claim data from 19,557 South Korean pediatric and adolescent patients (<20 years) who were diagnosed with schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, attention deficit-hyperactivity disorder (ADHD), or a tic disorder. Among these diseases, depressive episodes were the most common, followed by an anxiety disorder, ADHD, bipolar disorder, tic disorder, and schizophrenia. For each disease, prescriptions were categorized as full-label (approved indication with pediatric dosing in the package insert (PI)), partial-label (approved indication without pediatric dosing in the PI), and contraindication (contraindicated for the specific pediatric age in the PI). For schizophrenia, major depressive disorder, and anxiety disorder, more than 50% of the patients were prescribed partial-labeled medications. Additionally, more than 5% of patients with major depressive disorder were prescribed medications that were contraindicated for their age group. Our findings reveal that children with full-labeled psychiatric conditions are commonly administered drugs that are not explicitly approved for either their disease state or age, including off-label and unlicensed drugs. To use pharmaceuticals more safely, expanding drug indications using real-world data are needed.
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Popoli, Patrizia, Giovanni Giuliani, Arturo Cavaliere, and Claudio Jommi. "Early access programs for medicines: a reform proposal for the Italian National Health Service." Global and Regional Health Technology Assessment 11, no. 1 (June 17, 2024): 148–53. http://dx.doi.org/10.33393/grhta.2024.3098.
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The present paper illustrates a reform proposal on early access for medicines. In this proposal early access stands for patient’s access, outside of clinical trials and covered by the Italian National Health Service (Servizio Sanitario Nazionale, SSN), to a new medicine or an indication of an already approved medicine before the approval o in between the approval and the decision on price and reimbursement status. The proposal emerged from a multi-stakeholder working group within the Sixth Edition of the “Seminari di Mogliano Veneto”. The reform proposal is aimed at converting the current early access programs (mainly, the programs introduced with Laws 648/96 and 326/03) into a single program inspired by the one introduced in France in 2021. The proposal provides indications on eligibility criteria for drugs and patients, application procedure, evaluation process, economic safeguard clauses, data collection, issues derived from the circumstance that the drug/indication included into the early access program is not reimbursed afterwards and the actions to implement this program.
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Heni Trisnowati, Rika Yulianti Fitri, Rizanna Rosemary, and Ariyanto Nugroho. "Opportunity for a Healthy Campus Program as a Sustainable Development Goal: Assessing Lifestyle Factor and Mental Health Status." Jurnal Promkes 12, SI 1 (January 26, 2024): 20–28. http://dx.doi.org/10.20473/jpk.v12.isi1.2024.20-28.
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Background: Globally, mental health has become a major issue in health development today. Campus communities cannot be separated from the problem of mental health. Aims: This study aims to describe the relationship between demographic and lifestyle factors with mental health status in campus communities. Method: This study used a quantitative method with a cross-sectional design. Data collection was conducted through an online survey on 11-30 October 2021 at one of the universities in Yogyakarta. There were 503 respondents consisting of students, lecturers, and education staff. The instrument of mental health was the Self-Reporting Questionnaire-29 (SRQ-29). Result: There were indications of needing referral due to anxiety and depression as much as 33.4%, and there were 5.28% of respondents requiring referral due to psychotic disorders, drugs, and PTSD. Demographic factors associated with mental health status were job status, sex, and age. Meanwhile, lifestyle aspects that are associated with mental health status are physical activity duration and fruit and vegetable consumption per day. This was indicated by the respective p-values of 0.000 (job status), 0.042 (sex), 0.027 (age), 0.003 (duration of physical activity), and 0.011 (consumption of fruits and vegetables per day). Furthermore, multivariate analysis showed that the duration of physical activity, as well as fruit and vegetable consumption, had a negative linear effect on the incidence of mental health disorders. Conclusion: The main findings provide baseline data for developing healthy campuses as part of sustainable development goals (SDGs), particularly for mental health programs.
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Fulgoni, Kristin, Victor L. Fulgoni, and Taylor C. Wallace. "Association of Total, Added, and Natural Phosphorus Intakes with Biomarkers of Health Status and Mortality in Healthy Adults in the United States." Nutrients 14, no. 9 (April 22, 2022): 1738. http://dx.doi.org/10.3390/nu14091738.
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The Western diet is high in dietary phosphorus, partially due to added phosphorus, (i.e., phosphates) predominantly present in processed food products. Elevated serum phosphate levels, otherwise known as hyperphosphatemia, have been associated with changes in health status, of note detrimental effects on cardiovascular and renal health. However, the extent to which highly absorbed added phosphorus contributes to these changes is relatively unknown, due to its poor characterization among food composition databases. Industry-provided data on phosphorus source ingredients and ranges of added phosphorus present in food categories to enable a more accurate estimation of the total, added, and natural phosphorus intakes in the U.S. population. Using regression analyses, we then assessed relationships between estimated total, added, and natural phosphorus intakes on biomarkers of health status and mortality in individuals enrolled in the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 2001–2016 datasets. Total, added, and natural phosphorus intakes were associated with several biomarkers of health status. Added phosphorus intake was consistently inversely associated with HDL cholesterol in both men and women, whereas naturally occurring phosphorus intake was inversely correlated with the risk of elevated blood pressure. However, in most cases, the predicted impact of increases in phosphorus intake would result in small percentage changes in biomarkers. No meaningful associations between phosphorus and mortality were found, but indications of a correlation between mortality with quintiles of naturally occurring phosphorus were present, depending on covariate sets used. The disparate results for natural and added phosphorus intakes within the current study provide increased support for updating current food composition databases to more accurately account for dietary phosphorus intake as total, naturally occurring, and added phosphorus.
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Etemady, Mike, Melika Hajizadeh, Beata Gidaszewski, Julie Ann Swain, Seng Chai Chua, and Marjan Khajehei. "Use of iron in perinatal anaemia: Indications for women’s health care policies and procedure." World Journal of Obstetrics and Gynecology 12, no. 4 (December 28, 2023): 33–44. http://dx.doi.org/10.5317/wjog.v12.i4.33.
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This paper reviews management of obstetric anaemia and the role of intravenous iron for the treatment of obstetric anaemia. Red blood cell transfusions are routinely used for haemoglobin restoration in anaemic women. The decision for red blood cell transfusion is made on a combination of haemoglobin level and clinical status, and it is suggested that transfusions are not necessary in those who are well compensated or when alternative therapy is available. To reduce the risk, intravenous iron infusion is proposed as a bloodless therapeutic approach. There are a variety of iron preparations. Intravenous iron infusion can reduce the requirement for blood transfusion in hemodynamically stable women with perinatal anaemia, especially in resource-scarce settings. It a cost-effective bloodless approach for the treatment of anaemia than can enhance patient outcomes. According to the literature, when haemoglobin is greater than 90 g/L, blood transfusion is not often required. In perinatal women with anaemia, the decision whether to administer blood or iron is based on patient preferences, haemoglobin levels, clinical symptoms, past and present medical conditions and the clinician’s judgement. Nevertheless, due to the lack of rigid criteria for blood transfusions in the majority of clinical settings, it is considered the default treatment for anaemia in perinatal women.
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Lee, Sung Min, Tag Heo, Giwoon Kim, and Hyun Kim. "Current status and development direction of hyperbaric medicine in Korea." Journal of the Korean Medical Association 65, no. 4 (April 10, 2022): 232–38. http://dx.doi.org/10.5124/jkma.2022.65.4.232.
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Background: The indications of hyperbaric oxygen therapy (HBOT) covered by the health insurance in Korea increased to 16 in 2019, which includes acute central retinal artery obstruction within 24 hours of vision loss; anemia due to excessive bleeding, since blood transfusion is impractical; chronic refractory osteomyelitis (Wagner grade ≥3); and intracranial abscess.Current Concepts: HBOT affects the treatment in the primary and secondary mechanisms. According to the Boyle’s law, the primary mechanism is important in treating decompression sickness and intravascular air embolism by decreasing the volume of air bubbles when pressure increases, whereas the secondary mechanism involves hyperoxygenation of the primary mechanism and various effects, such as vasoconstriction, angiogenesis, immune function enhancement, reperfusion injury prevention, antimicrobial action, and gas washout effect, occur. In the past 5 years, domestic HBOT has made significant progress. However, there are many non-therapeutic lowpressure HBOT facilities that are limited by insurance coverage issues, quality equipment management, and medical personnel in HBOT facilities.Discussion and Conclusion: To solve the problem, the introduction of the definition of therapeutic hyperbaric pressure and certification system of HBOT facilities must be initiated. Moreover, the system should be improved so that insurance can be applied for a more indication of HBOT.
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Lee, Sung Min, Tag Heo, Giwoon Kim, and Hyun Kim. "Current status and development direction of hyperbaric medicine in Korea." Journal of the Korean Medical Association 65, no. 4 (April 10, 2022): 232–38. http://dx.doi.org/10.5124/jkma.2022.65.4.232.
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Background: The indications of hyperbaric oxygen therapy (HBOT) covered by the health insurance in Korea increased to 16 in 2019, which includes acute central retinal artery obstruction within 24 hours of vision loss; anemia due to excessive bleeding, since blood transfusion is impractical; chronic refractory osteomyelitis (Wagner grade ≥3); and intracranial abscess.Current Concepts: HBOT affects the treatment in the primary and secondary mechanisms. According to the Boyle’s law, the primary mechanism is important in treating decompression sickness and intravascular air embolism by decreasing the volume of air bubbles when pressure increases, whereas the secondary mechanism involves hyperoxygenation of the primary mechanism and various effects, such as vasoconstriction, angiogenesis, immune function enhancement, reperfusion injury prevention, antimicrobial action, and gas washout effect, occur. In the past 5 years, domestic HBOT has made significant progress. However, there are many non-therapeutic lowpressure HBOT facilities that are limited by insurance coverage issues, quality equipment management, and medical personnel in HBOT facilities.Discussion and Conclusion: To solve the problem, the introduction of the definition of therapeutic hyperbaric pressure and certification system of HBOT facilities must be initiated. Moreover, the system should be improved so that insurance can be applied for a more indication of HBOT.
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Lee, Sung Min, Tag Heo, Giwoon Kim, and Hyun Kim. "Current status and development direction of hyperbaric medicine in Korea." Journal of the Korean Medical Association 65, no. 4 (April 10, 2022): 232–38. http://dx.doi.org/10.5124/jkma.2022.65.4.232.
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Background: The indications of hyperbaric oxygen therapy (HBOT) covered by the health insurance in Korea increased to 16 in 2019, which includes acute central retinal artery obstruction within 24 hours of vision loss; anemia due to excessive bleeding, since blood transfusion is impractical; chronic refractory osteomyelitis (Wagner grade ≥3); and intracranial abscess.Current Concepts: HBOT affects the treatment in the primary and secondary mechanisms. According to the Boyle’s law, the primary mechanism is important in treating decompression sickness and intravascular air embolism by decreasing the volume of air bubbles when pressure increases, whereas the secondary mechanism involves hyperoxygenation of the primary mechanism and various effects, such as vasoconstriction, angiogenesis, immune function enhancement, reperfusion injury prevention, antimicrobial action, and gas washout effect, occur. In the past 5 years, domestic HBOT has made significant progress. However, there are many non-therapeutic lowpressure HBOT facilities that are limited by insurance coverage issues, quality equipment management, and medical personnel in HBOT facilities.Discussion and Conclusion: To solve the problem, the introduction of the definition of therapeutic hyperbaric pressure and certification system of HBOT facilities must be initiated. Moreover, the system should be improved so that insurance can be applied for a more indication of HBOT.
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Moorhead, Kathleen, and Maryam Guiahi. "Pregnancy Complicated by Ludwig's Angina Requiring Delivery." Infectious Diseases in Obstetrics and Gynecology 2010 (2010): 1–3. http://dx.doi.org/10.1155/2010/158264.
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At 33 weeks of gestation, a 24-year-old developed Ludwig's angina that worsened despite aggressive therapy. This is the first reported case of Ludwig's Angina in pregnancy that required an emergent cesarean section for fetal indications. Delivery may have contributed to improvement in the mother's health status.
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Teleeva, G. I., L. S. Tselkovich, R. B. Balter, T. V. Ivanova, A. R. Ibragimova, and A. Yu Ryabov. "Features of the health status of women with genital prolapse." Meditsinskiy sovet = Medical Council, no. 21 (January 17, 2021): 210–17. http://dx.doi.org/10.21518/2079-701x-2020-21-210-217.
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Introduction. In recent years, more and more attention has been paid to the issues of genital prolapse. This is largely due to the increase in women life expectancy and the need to provide them with a decent quality of life, as prolapse is quite often accompanied by dysfunction of the pelvic organs. In recent years, there has been an increasing amount of literature on undifferentiated connective tissue dysplasia (UCTD). However, most of these studies consider therapeutic or vertebro-neurological problems, while the high prevalence rates of this pathology call for additional research on the pathogenetic mechanisms of the effect of UCTD on pelvic organ prolapse, which will allow us to decide on the choice of subsequent treatment.The purpose and objectives. Asess the effect of undifferentiated connective tissue dysplasia (UCTD) on the formation of disorders of the somatic, gynecological and reproductive health status in women with genital prolapse.Materials and methods. To achieve this goal, we examined 204 women with genital prolapse in the POP-Q classification of stage 2–3, of which 97 were diagnosed with UCTD (the main group), and the remaining 107 patients made up the comparison group.Results. To evaluate the influence of UCTD on the formation of somatic, gynecological and reproductive health disorders in women with genital prolapse. We analyzed anamnestic indications for somatic, gynecological and reproductive pathology of women, as well as assessed the current state of health of patients with genital prolapse. It was found that it is UCTD that determines the development of a particular form of gynecological pathology and affects the formation of genital prolapse.Conclusion. UCTD manifests as various forms of somatic and gynecological health disorders throughout the life of women with genital prolapse.
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Xie, Jiacheng, Congcong Jing, Ziyang Zhang, Jiatuo Xu, Ye Duan, and Dong Xu. "Digital tongue image analyses for health assessment." Medical Review 1, no. 2 (December 1, 2021): 172–98. http://dx.doi.org/10.1515/mr-2021-0018.
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Abstract Traditional Chinese Medicine (TCM), as an effective alternative medicine, utilizes tongue diagnosis as a major method to assess the patient’s health status by examining the tongue’s color, shape, and texture. Tongue images can also give the pre-disease indications without any significant disease symptoms, which provides a basis for preventive medicine and lifestyle adjustment. However, traditional tongue diagnosis has limitations, as the process may be subjective and inconsistent. Hence, computer-aided tongue diagnoses have a great potential to provide more consistent and objective health assessments. This paper reviewed the current trends in TCM tongue diagnosis, including tongue image acquisition hardware, tongue segmentation, feature extraction, color correction, tongue classification, and tongue diagnosis system. We also present a case of TCM constitution classification based on tongue images.
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Althobaiti, Hana, Enrique Seoane-Vazquez, Lawrence M. Brown, Marc L. Fleming, and Rosa Rodriguez-Monguio. "Disentangling the Cost of Orphan Drugs Marketed in the United States." Healthcare 11, no. 4 (February 13, 2023): 558. http://dx.doi.org/10.3390/healthcare11040558.
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The increasing number and high prices of orphan drugs have triggered concern among patients, payers, and policymakers about the affordability of new drugs approved using the incentives set by the Orphan Drug Act (ODA) of 1983. This study evaluated the factors associated to the differences in the treatment cost of new orphan and non-orphan drugs approved by the FDA from 2017 to 2021. A generalized linear model (GLM) with the Gamma log-link analysis was used to ascertain the association of drug characteristics with the treatment costs of orphan and non-orphan drugs. The results of the study showed that the median and interquartile range (IQR) drug cost was USD 218,872 (IQR = USD 23,105) for orphan drugs and USD 12,798 (IQR = USD 57,940) for non-orphan drugs (p < 0.001). Higher market entry prices were associated with biologics (108%; p < 0.001), orphan status (177%; p < 0.001), US sponsor companies (48%; p = 0.035), chronic use (1083%; p < 0.001), treatment intent (163%; p = 0.004), and indications for oncology (624%; p < 0.001) or genetic disorders (624%; p < 0.001). Higher market entry treatment cost for newly approved drugs were associated with biologics, orphan status, US sponsor companies, chronic use, therapeutic intent, and indications for oncology or genetic disorders.
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Park, Taejun, Yun-Sook Jung, Keunbada Son, Yong-Chul Bae, Keun-Bae Song, Atsuo Amano, and Youn-Hee Choi. "More Teeth and Posterior Balanced Occlusion Are a Key Determinant for Cognitive Function in the Elderly." International Journal of Environmental Research and Public Health 18, no. 4 (February 19, 2021): 1996. http://dx.doi.org/10.3390/ijerph18041996.
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Age-related decline in cognitive function is a major challenge in geriatric healthcare. A possible explanation is that the tooth loss or low chewing ability is at cause of cognitive impairment or dementia. The study aimed to investigate the potential relationship between chewing ability and cognitive function in the elderly. A total of 563 participants aged 65 years or over residing in urban and rural areas of South Korea were surveyed. The chewing ability was measured by objectively measurable indications such as the number of remaining teeth, denture status, color-changeable gum, and occlusal balance using T-Scan III®. The cognitive function was measured by the Korean version of Mini-Mental State Examination-Dementia Screening (MMSE-DS) and a score of 24 or more (out of 30) indicates a normal cognition, below 23 indicates cognitive impairment. The association between socio-demographic factors, chewing ability factors, and cognitive function demonstrated statistically significant results. When comparing the denture status and chewing ability, the proportion of need denture group had fewer remaining teeth and anterior balanced occlusion. The average number of remaining teeth in anterior balanced occlusion with cognitive impairment was 11.2 compared to posterior balanced occlusion with the normal cognition 19.2. A multiple linear regression analysis declared a significant correlation between number of remaining teeth, denture status, occlusal balance, and cognitive function. Results of the present study revealed objectively measurable indications are suitable for chewing ability assessment and correlated with cognitive function.
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Gualdi-Russo, Emanuela, Luciana Zaccagni, Giovanna V. Dallari, and Stefania Toselli. "Anthropometric parameters in relation to glycaemic status and lipid profile in a multi-ethnic sample in Italy." Public Health Nutrition 18, no. 3 (April 24, 2014): 438–45. http://dx.doi.org/10.1017/s1368980014000615.
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AbstractObjectiveTo examine the health status of ethnic minorities in Italy. Furthermore, we aimed to assess the association between anthropometric and blood parameters connected with health status.DesignA cross-sectional study. Anthropometric data were collected by direct measurements and blood glucose, total cholesterol and TAG were analysed.SettingBologna, northern Italy.SubjectsA multi-ethnic sample of adult immigrants and Roma.ResultsSignificant correlations between anthropometric and blood parameters were found. Among the ethnic groups, Roma males had the highest values of glucose, total cholesterol and TAG. In the females the situation was more balanced among ethnic groups.ConclusionsThe data from this survey indicate that poor health status is a very common problem among ethnic groups living in Italy, especially the Roma. The use of anthropometric parameters as rapid indicators of health status in screenings of a large number of subjects could be an effective and cheap method to provide preliminary indications on individuals or ethnic groups at greater risk of poor health.
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Jahan, Rowshan Hosne. "Incidence and Complications of Emergency Peripartum Hysterectomy: A Retrospective Study at Maternal and Child Health Training Institute, Dhaka." Journal of Armed Forces Medical College, Bangladesh 13, no. 1 (April 23, 2017): 106–10. http://dx.doi.org/10.3329/jafmc.v13i1.41069.
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Introduction: Emergency peripartum hysterectomy (EPH) is a major surgical venture performed in the setting of life threatening hemorrhage during or immediately after abdominal and vaginal deliveries. In developing countries, 8-10% of maternal mortality directly occurs due to massive obstetrical hemorrhage. Most common indication for emergency peripartum hysterectomy has been uterine atony and uterine rupture. The decision to perform an emergency hysterectomy on a young woman especially one with low parity poses a dilemma for the obstetrician particularly in our society.
Objective: To estimate incidence, indications and postoperative complications associated with emergency hysterectomy at Maternal and Child Health Training Institute (MCHTI), Azimpur, Dhaka.
Materials and Methods: This is a retrospective study and registration numbers of all women who underwent emergency peripartum hysterectomy were indentified. With the numbers, the case notes were retrieved from the medical records department for in-depth study. Information abstracted included the socio-demographic characteristics of the patients, indications for the hysterectomy, type of hysterectomy performed, booking status of patients, mode of delivery, gestational age at delivery and maternal outcome were recorded in a pre-designed data form. The data were analyzed using simple proportion, rates and tables.
Results: There were 18 cases of emergency peripartum hysterectomies performed during the study period of January 2011 to December 2013 (incidence 1.26/1000 deliveries). Commonest age of the middle group was 29-34 years. Ruptured uterus was the commonest indication (9 cases, 50%) and other indications were uterine atony/ PPH (8 cases, 44.44%), placenta praevia (1 case, 5.56%). Subtotal abdominal hysterectomy was done in 17(94.44%) cases whereas total abdominal hysterectomy in 01(5.56%) cases. This emergency procedure was associated with significant number of intraoperative and postoperative complications, However maternal and perinatal outcome was satisfactory.
Conclusion: EPH remains an essential life saving procedure and its incidence continues to remain high in our community when compared with developed countries. Effective antenatal care, identification of patients at risk, enhancement of blood transfusion facilities together with improvement of surgical skills are important to reduce the incidence of peripartum hysterectomy as well as morbidity and mortality.
Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 106-110
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Kaufman, Christina L., Neal Bhutiani, Allan Ramirez, Huey Y. Tien, Michelle D. Palazzo, Elkin Galvis, Scott Farner, Tuna Ozyurekoglu, and Christopher M. Jones. "Current Status of Vascularized Composite Allotransplantation." American Surgeon 85, no. 6 (June 2019): 631–37. http://dx.doi.org/10.1177/000313481908500628.
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The field of vascularized composite allotransplantation (VCA) has moved from a highly experimental procedure to, at least for some patients, one of the best treatment alternatives for catastrophic tissue loss or dysfunction. Although the worldwide experience is still limited, progress has been made in translation to the clinic, and hand transplantation was recently designated standard of care and is now covered in full by the British Health System. This progress is tempered by the long-term challenges of systemic immunosuppression, and the rapidly evolving indications for VCA such as urogenital transplantation. This update will cover the state of and recent changes in the field, and an update of the Louisville VCA program as our initial recipient, the first person to receive a hand transplant in the United States celebrates the 20th anniversary of his transplant. The achievements and complications encountered over the last two decades will be reviewed. In addition, potential directions for research and collaboration as well as practical issues of how third party payers and funding are affecting growth of the field are presented.
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Garrido, Lisetty, Patrícia Lyra, Joana Rodrigues, João Viana, José João Mendes, and Helena Barroso. "Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness." Journal of Personalized Medicine 13, no. 9 (August 29, 2023): 1332. http://dx.doi.org/10.3390/jpm13091332.
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A good oral health status is mostly dependent on good oral hygiene habits, which knowingly impacts systemic health. Although controversial, chemical oral antiseptics can be useful in adjunct use to mechanical dental plaque control techniques in the prevention and management of local and overall health and well-being. This review aims to revisit, gather and update evidence-based clinical indications for the use of the most popular oral antiseptics, considering different types, microorganism targets and effectiveness in order to establish updated clinical recommendations.
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Mayberry, John C., Andrew D. Kroeker, L. Bruce Ham, Richard J. Mullins, and Donald D. Trunkey. "Long-Term Morbidity, Vain, and Disability after Repair of Severe Chest Wall Injuries." American Surgeon 75, no. 5 (May 2009): 389–94. http://dx.doi.org/10.1177/000313480907500508.
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Long-term morbidity after severe chest wall injuries is common. We report our experience with acute chest wall injury repair, focusing on long-term outcomes and comparing our patients’ health status with the general population. We performed a retrospective medical record review supplemented with a postal survey of long-term outcomes including the McGill Pain Questionnaire (MPQ) and RAND-36 Health Survey. RAND-36 outcomes were compared with reference values from the Medical Outcomes Study and from the general population. Forty-six patients underwent acute chest wall repair between September 1996 and September 2005. Indications included flail chest with failure to wean from the ventilator (18 patients), acute, intractable pain associated with severely displaced rib fractures (15 patients), acute chest wall defect/deformity (5 patients), acute pulmonary herniation (3 patients), and thoracotomy for other traumatic indications (5 patients). Three patients had a concomitant sternal fracture repair. Fifteen patients with a current mean age of 60.6 years (range 30-91) responded to our surveys a mean of 48.5 ± 22.3 months (range 19-96) postinjury. Mean long-term MPQ Pain Rating Index was 6.7 ± 2.1. RAND-36 indices indicated equivalent or better health status compared with references with the exception of role limitations due to physical problems when compared with the general population. The operative repair of severe chest wall injuries is associated with low long-term morbidity and pain, as well as health status nearly equivalent to the general population. Both the MPQ and the RAND-36 surveys were useful tools for determining chest wall pain and disability outcomes.
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Okonkwo, Ogugua Ndubuisi, Karinya Lewis, Adekunle Olubola Hassan, Micheal Ekuoba Gyasi, Banji Oluyadi, Adunola Ogunro, Olufemi Oderinlo, and Mildred Ulaikere. "Indications and outcomes of vitrectomy surgery in a series of 1000 black African eyes." BMJ Open Ophthalmology 4, no. 1 (May 2019): e000083. http://dx.doi.org/10.1136/bmjophth-2017-000083.
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ObjectiveTo determine the common indications for, and outcomes of pars plana vitrectomy surgery among black Africans in a low-resource setting.Methods and AnalysisA retrospective, non-comparative case review was undertaken. Data from 1000 consecutive eyes of 1000 patients in a single centre who underwent pars plana vitrectomy surgery between May 2005 and July 2013 were used for the study. Demographic data, primary indication for surgery, ocular status and outcomes were assessed.ResultsRhegmatogenous retinal detachment was the most common primary indication occurring in 61.8% of eyes. Diabetic vitrectomy, trauma and proliferative sickle cell retinopathy were also common indications occurring in 10.1%, 6.1% and 4.5% of eyes, respectively. At presentation, 33% of patients with retinal detachment had some form of proliferative vitreoretinopathy, and half of those had the more advanced grades C and D. Patients presented on an average of 13.5 months after onset of symptoms. As a result, visual outcomes were less than other reported studies.ConclusionRetinal detachment was the most common indication for vitrectomy, but even these cases presented late with an advanced presentation. This study highlights the need for affordable and accessible vitreoretinal services in Sub-Saharan Africa and increased awareness of general eye health, along with strategies to reduce trauma and identify early those at risk of chronic eye diseases, such as diabetic retinopathy and sickle cell retinopathy.
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Radwan-Oczko, Małgorzata, Irena Duś-Ilnicka, Pamela Richards, Anna Marie Thomsen, and Claus Rasmussen. "Evaluation of Oral Health Status and Oral Care of Patients with Rheumatoid Arthritis." International Journal of Dentistry 2020 (October 30, 2020): 1–7. http://dx.doi.org/10.1155/2020/8896766.
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Objective. Rheumatoid arthritis (RA) and periodontal disease (PD) are common chronic, immunoinflammatory, destructive, and progressive diseases; however, the correlations between those two are not yet widely discussed. The purpose of this study was to evaluate the relationship between the selected demographic and clinical parameters of RA patients and oral health status parameters, on the basis of self-assessment. Materials and Methods. Three hundred patients under treatment were included in the study. Questionnaires were completed by 164 out of 300 patients. Results. A total of 100 females and 64 males took part in the study, with a mean age of 65 ± 11.1 years. In younger patients, the disease activity score (DAS28) was higher, and it was associated with pain or discomfort in the oral cavity and with difficulties in toothbrushing. Discomfort or pain in the oral cavity was to a significant extent associated with the poor gingival state, gingival bleeding, and difficulties in biting or chewing. Conclusions. In RA patients, difficulties in biting or chewing, discomfort or pain in oral cavity, feeling of the presence of movable teeth, and gingival bleeding are indications of periodontal infection. Maintaining awareness of oral health and RA is a key issue in the simultaneous management of proper oral care and RA due to the mutual influence of those two factors.
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Török, Áron, Matthew Gorton, Ching-Hua Yeh, Péter Czine, and Péter Balogh. "Understanding Consumers’ Preferences for Protected Geographical Indications: A Choice Experiment with Hungarian Sausage Consumers." Foods 11, no. 7 (March 29, 2022): 997. http://dx.doi.org/10.3390/foods11070997.
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Geographical Indications (GIs) can increase producer margins and contribute to local economic development, but the extent to which they do so depends on the nature of consumer demand. A Discrete Choice Experiment (DCE) considers the value that consumers place on a Protected Geographical Indication (PGI) in comparison with a leading manufacturer’s brand, as well as the importance of taste variations. Based on an application of DCE to sausages in Hungary, results indicate that a PGI can generate value to consumers exceeding that conveyed by the leading manufacturer’s brand. Consumers’ taste preferences, however, may not be consistent with the specification of GI products. Latent Class (LC) and Random parameter Latent Class (RLC) analyses identify two consumer segments, with the majority of consumers (71%-LC, 65%-RLC) classified as traditionalists, who most value the GI label, while a minority (29%-LC, 35%-RLC) is brand conscious, for whom the GI status is less salient. Both theoretical and business implications for GI marketing and club branding are drawn.
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Michaeli, Daniel Tobias, Hasan Basri Yagmur, Timur Achmadeev, and Thomas Michaeli. "Valuation and Returns of Drug Development Companies: Lessons for Bioentrepreneurs and Investors." Therapeutic Innovation & Regulatory Science 56, no. 2 (January 11, 2022): 313–22. http://dx.doi.org/10.1007/s43441-021-00364-y.
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Abstract Objectives This study evaluates the association of Biopharma company valuation with the lead drug’s development stage, orphan status, number of indications, and disease area. We also estimated annual returns Bioentrepreneurs and investors can expect from founding and investing in drug development ventures. Methods SDC Thomson Reuter and S&P Capital IQ were screened for majority acquisitions of US and EU Biopharma companies developing new molecular entities for prescription use (SIC code: 2834). Acquisition data were complemented with drug characteristics extracted from clinicaltrials.gov, the US Food and Drug Administration (FDA), and deal announcements. Thereafter, company valuations were combined with previously published clinical development periods alongside orphan-, indication-, and disease-specific success rates to estimate annual returns for investments in drug developing companies. Results Based on a sample of 311 Biopharma acquisitions from 2005 to 2020, companies developing orphan, multi-indication, and oncology drugs were valued significantly higher than their peers during later development stages (p < 0.05). We also estimated significantly higher returns for shareholders of companies with orphan relative to non-orphan-designated lead drugs from Phase 1 to FDA approval (46% vs. 12%, p < 0.001). Drugs developed across multiple indications also provided higher returns than single-indication agents from Pre-Clinic to FDA approval (21% vs. 11%, p < 0.001). Returns for oncology drugs exceeded other disease areas (26% vs. 8%, p < 0.001). Conclusions Clinical and economic conditions surrounding orphan-designated drugs translate to a favorable financial risk-return profile for Bioentrepreneurs and investors. Bioentrepreneurs must be aware of the upside real option value their multi-indication drug could offer when negotiating acquisition or licensing agreements.
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Rattigan, Ruth, Lukasz Wajda, Abel A. Vlasblom, Alan Wolfe, Aldert L. Zomer, Birgitta Duim, Jaap A. Wagenaar, and Peadar G. Lawlor. "Safety Evaluation of an Intranasally Applied Cocktail of Lactococcus lactis Strains in Pigs." Animals 13, no. 22 (November 8, 2023): 3442. http://dx.doi.org/10.3390/ani13223442.
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Three Lactococcus lactis strains from the nasal microbiota of healthy pigs were identified as candidates for reducing MRSA in pigs. The safety of nasal administration of a cocktail of these strains was examined in new-born piglets. Six days pre-farrowing, twelve sows were assigned to the placebo or cocktail group (n = 6/group). After farrowing, piglets were administered with either 0.5 mL of the placebo or the cocktail to each nostril. Health status and body weight were monitored at regular time points. Two piglets from three sows/treatment group were euthanised at 24 h, 96 h and 14 d after birth, and conchae, lung and tonsil samples were collected for histopathological and gene expression analysis. Health scores were improved in the cocktail group between d1–5. Body weight and daily gains did not differ between groups. Both groups displayed histological indications of euthanasia and inflammation in the lungs, signifying the findings were not treatment related. The expression of pBD2, TLR9 and IL-1β in the nasal conchae differed between groups, indicating the cocktail has the potential to modulate immune responses. In summary, the L. lactis cocktail was well tolerated by piglets and there was no negative impact on health scores, growth or lung histopathology indicating that it is safe for administration to new-born piglets.
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Wang, Candice PY, Wei Ching Tan, Devendra Kanagalingam, and Hak Koon Tan. "Why We Do Caesars: A Comparison of the Trends in Caesarean Section Delivery over a Decade." Annals of the Academy of Medicine, Singapore 42, no. 8 (August 15, 2013): 408–12. http://dx.doi.org/10.47102/annals-acadmedsg.v42n8p408.
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Introduction: In the United Kingdom, caesarean section (CS) rates have increased from 9% of deliveries in 1980 to 21% in 2001. A similar increase in CS rates has been seen in many developed countries. This is beyond the World Health Organisation’s (WHO’s) recommended level of 15%. This is a worrying trend as the risks of placenta previa, placenta accreta, hysterectomies, bladder and bowel injuries are increased with subsequent CS. We aim to ascertain the commonest indications for CS in a tertiary hospital and make recommendations to decrease future CS rates. Materials and Methods: This retrospective analysis compares the 5 most common indications for CS in 1999 and 2009. CS rates in the 2 study periods are tabulated and analysed as well. Results: In the first study period between January and December 1999, there were 2048 deliveries of which 365 were via CS. In the second study period of a decade later from January to December 2009, there were 1572 deliveries of which 531 were via CS. This gives an increase in CS rate from 17.8% in 1999 to 34% in 2009. The main indications for CS in 1999 were: cephalopelvic disproportion (18.6%), breech (14.2%), non-reassuring fetal status (11.8%), 1 previous CS (11.2%) and pregnancy-induced hypertension/pre-eclampsia/eclampsia (6.6%). The main indications for CS in 2009 were: 1 previous CS (18.1%), non-reassuring fetal status (12.2%), cephalopelvic disproportion (10.5%), 2 or more previous CS (7.9%) and breech (7.7%). Conclusion: There is a significant increase in CS rates over the last decade with an increased percentage of CS done because of a previous CS. This is associated with increased risk of complications as well. Recommendations are suggested with the view to decrease future CS rates. Key words: Breech, Cephalopelvic disproportion, Non-reassuring fetal status, Previous caesarean section
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Thakor, Nitin R., Jayshree N. Tolani, and Pravender. "A demographic and descriptive study on depression status of adolescent population of Ahmedabad city in India." International Journal Of Community Medicine And Public Health 10, no. 3 (February 28, 2023): 1214–17. http://dx.doi.org/10.18203/2394-6040.ijcmph20230642.
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Background: Depressive indications and spirituality are prevalent all around the world, but their coherent existence has received moderately minute consideration from majority psychological health experts. This quantitative research examines relationships between spiritual participation and depressive indications or disorders. Religious beliefs and rituals possibly will aid public to deal with improved stressful life conditions, give sense and hope, and encircle unhappy people with an encouraging society. This study aimed to investigate the role that spiritual factors play in inhibiting depression and will lend a hand to determine whether this is a resource or a liability in adult age group. Methods: The present study was carried out in Ahmedabad city in the period from November to December 2022. A total of 400 adults were included in the study, which were selected using multi-stage sampling aged between 18 years to 59 years. Results: The obese adults had significantly higher depression levels. Depression had a negative correlation with spirituality levels. Regression analysis also demonstrated that the spirituality was one of the influencing factors affecting depression. Conclusions: Spirituality is negatively associated with depression.
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Ross, Christina L. "Energy Medicine: Current Status and Future Perspectives." Global Advances in Health and Medicine 8 (January 2019): 216495611983122. http://dx.doi.org/10.1177/2164956119831221.
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Current practices in allopathic medicine measure different types of energy in the human body by using quantum field dynamics involved in nuclear medicine, radiology, and imaging diagnostics. Once diagnosed, current treatments revert to biochemistry instead of using biophysics therapies to treat the disturbances in subtle energies detected and used for diagnostics. Quantum physics teaches us there is no difference between energy and matter. All systems in the human being, from the atomic to the molecular level, are constantly in motion-creating resonance. This resonance is important to understanding how subtle energy directs and maintains health and wellness in the human being. Energy medicine (EM), whether human touch or device-based, is the use of known subtle energy fields to therapeutically assess and treat energetic imbalances, bringing the body’s systems back to homeostasis (balance). The future of EM depends on the ability of allopathic medicine to merge physics with biochemistry. Biophoton emissions as well as signal transduction and cell signaling communication systems are widely accepted in today’s medicine. This technology needs to be expanded to include the existence of the human biofield (or human energy field) to better understand that disturbances in the coherence of energy patterns are indications of disease and aging. Future perspectives include understanding cellular voltage potentials and how they relate to health and wellness, understanding the overlap between the endocrine and chakra systems, and understanding how EM therapeutically enhances psychoneuroimmunology (mind–body) medicine.
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Ilyenkova, N. A., L. V. Stepanova, O. S. Konopleva, O. V. Alekseeva, and S. Yu Pastukhova. "Asthmatic status in pediatric practice. Clinical case." Perm Medical Journal 36, no. 4 (October 17, 2019): 88–96. http://dx.doi.org/10.17816/pmj36488-96.
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Bronchial asthma (BA) is a global issue of public health care that is connected with a stable tendency to sickness rate growth. In Russia, mortality rate from BA exacerbation is one of the highest in the world. The most severe attack of BA is considered as asthmatic status (AS) and needs resuscitation measures. Despite the fact that death from BA occurs as a result of acute severe attack (often asthmatic status), it is almost always the consequence of previous incorrect treatment or the absence of proper medical care and observation. The paper presents a clinical case of asthmatic status in a twelve-year old child, which was complicated by spontaneous pneumothorax. The cause of the development of threatening status in a child with bronchial asthma was the absence of basic anti-inflammatory therapy and proper medical observation. The absence of rational therapy and regular observation, rendered to BA patient by a physician of primary care link with training of self-control and self-observation habits, can cause the development of the most severe exacerbation asthmatic status. A timely hospitalization of AS patients to resuscitation and intensive care unit according to indications will promote faster transfer to pediatric department.
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Kornosenko, Oksana K., Oksana V. Danysko, Valeriy O. Zhamardiy, Vasyl V. Fazan, Kateryna Yu Horbenko, Yana V. Demus, and Viktoriia І. Donchenko. "PROJECTING OF HEALTH PROGRAMS FOR POST-COVID PATIENTS AT FITNESS CENTERS." Acta Balneologica 65, no. 3 (2023): 159–64. http://dx.doi.org/10.36740/abal202303105.
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Aim: To develop and substantiate a complex health and fitness program «Fitness Energy» for restoration of health of people who suffered from COVID-19 and experimentally verify its effectiveness at fitness centers. Materials and Methods: As a part of the research the complex assessment of somatic health status of people who suffered from COVID-19 was made using tests (Ruffier-Dickson Index, Stange and Gencha tests, Harvard step test, absolute and relative PWC 170). Results: The health and fitness program «Fitness Energy» is developed, implemented and experimentally verified as a complex of selective breathing and aerobic exercises which are done in a particular order and allow acting deliberately on human body of people who suffered from COVID-19 to secure the maximum health-improvement effect. Conclusions: Experimental research confirmed the effectiveness of health and fitness program «Fitness Energy», in particular the overall result upon indications of functional status of people in experimental group (25,78 %) 17,5 % higher than in control one (8,22 %). This indicates the effectiveness of rehabilitation patients, in particular, improves the cardiovascular and respiratory systems, strengthens the muscles involved in respiration, increases the overall tone and efficiency of the body.
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Gratwohl, Alois, Helen Baldomero, Bruno Horisberger, Caroline Schmid, Jakob Passweg, and Alvaro Urbano-Ispizua. "Current trends in hematopoietic stem cell transplantation in Europe." Blood 100, no. 7 (October 1, 2002): 2374–86. http://dx.doi.org/10.1182/blood-2002-03-0675.
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Major changes have occurred in the transplantation of hematopoietic stem cells (HSCs) during the last decade. This report reveals the changes, reflects current status, and provides medium-term projections of HSC transplantation (HSCT) development in Europe. Data on 132 963 patients, 44 165 with allogeneic HSC transplant (33%) and 88 798 with an autologous HSC transplant (67%), collected prospectively from 619 centers by the European Group for Blood and Marrow Transplantation (EBMT) in 35 European countries between 1990 (4234 HSCTs) and 2000 (19 136 HSCTs) illustrate utilization of HSCT. HSCT increased in all European countries and for all indications. There were major differences depending on disease indication and donor type. Transplantation rates (numbers of HSCTs per 10 million inhabitants) varied from less than 1 for some rare indications to 37.7 ± 4.1 for acute myeloid leukemia in allogeneic HSCT or 95.5 ± 13.5 for non-Hodgkin lymphoma in autologous HSCT. There were indications with a steady, continuing increase and others with initial increase but subsequent decrease. Projections on medium-term development for each disease based on a weighted sensitivity analysis predict an ongoing increase in allogeneic HSCT except for chronic myeloid leukemia. In autologous HSCT they predict an increase for lymphoproliferative disorders, acute myeloid leukemia, myelodysplastic syndromes, and some solid tumors but a decrease for most solid tumors, acute lymphoid leukemia, and chronic myeloid leukemia. Transplantation rates can be predicted with reasonable sensitivity for most disease indications. Despite marked changes in the rapidly developing field of HSCT, this information on current use, trends, and midterm predictions forms a rational basis for patient counseling and health care planning.
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Jedele, Jenefer, Cameron Griffin, and Julie Weitlauf. "Indicators of Elder Mistreatment: Correlates among Veterans Receiving Care in the Veterans Health Administration." Innovation in Aging 5, Supplement_1 (December 1, 2021): 877. http://dx.doi.org/10.1093/geroni/igab046.3195.
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Abstract Among community-dwelling adults ages 65 and older, approximately 11% have experienced elder mistreatment (EM), including physical, emotional or sexual abuse, neglect, or financial exploitation. EM research typically focuses on this age group; however, Veterans receiving Veterans Health Administration (VHA) care have increased earlier morbidity, which may accelerate the impacts of EM. Using a cohort of all VHA Veterans 50 years and older with VHA use in 2018-2020, we examined correlates of EM. ICD-10 codes from clinical encounters identified Veterans with indications of EM (n=4,427). A 10% sample of Veterans without indications of EM was selected for comparison (n=530,535). Logistic regression compared EM+ Veterans to the comparison sample and assessed overall demographic and clinical differences as well as differences by age, i.e. 50-64 versus 65 and older. Overall, female gender (OR=5.3, 95% CI=4.3-6.5), non-white race/ethnicity (OR=1.7, CI=1.5-1.9), dementia (OR=3.0, CI=2.6-3.5), PTSD (OR=2.0, CI=1.6-2.5), anxiety (OR=1.3, CI=1.0-1.5), military service connected disability status (OR=1.3, CI=1.1-1.5), and higher Elixhauser medical morbidity scores (OR=1.1, CI=1.1-1.1) were associated with EM. Prior year ER visits (OR=28.0, CI=23.6-33.4), inpatient stays (OR=14.0, CI=11.5-17.0), and mental health visits (OR=26.1, CI=22.2-30.6) also predicted EM+ status. Forty-six percent of VHA Veterans with indicators of EM were aged 50-64. For these Veterans, female gender, PTSD, service connection, and mental health visits were associated with increased risk of EM compared to Veterans 65+. Findings highlight clinical correlates of EMs among Veterans in VHA care. Increased awareness of EM risk factors is warranted and may inform VHA efforts for EM prevention, detection and intervention.
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van der Poest Clement, Emma A., Mustafa Sahin, and Jurriaan M. Peters. "Vigabatrin for Epileptic Spasms and Tonic Seizures in Tuberous Sclerosis Complex." Journal of Child Neurology 33, no. 8 (April 24, 2018): 519–24. http://dx.doi.org/10.1177/0883073818768309.
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Vigabatrin is recommended as first-line treatment for infantile spasms in tuberous sclerosis complex (TSC), but other indications in children with tuberous sclerosis complex are less known. We retrospectively reviewed 201 children with tuberous sclerosis complex, and identified 21 children older than 1 year started on vigabatrin for any indication and with sufficient follow-up data. The indication for vigabatrin was epileptic spasms (n = 13), tonic seizures (n = 5), both (n = 2), and status epilepticus (n = 1). Mean age of treatment onset was 4.0 years (range 1.1-18.3). All but 1 patient had a reduction in seizures. Ten patients became seizure free and 4 had an improvement of >90%. In 9 patients, vigabatrin was tapered successfully after 8 to 33 months. Side effects reported included rash (n = 1) and behavioral decline (n = 1). No retinal toxicity was detected in 14 of 21 patients with adequate ophthalmologic surveillance data. In conclusion, vigabatrin may be an effective treatment for epileptic spasms and tonic seizures beyond the infantile age.
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Sungkar, Ali, and Ray Wagiu Basrowi. "Rising trends and indication of Caesarean section in Indonesia." World Nutrition Journal 4, no. 1-2 (October 1, 2020): 1. http://dx.doi.org/10.25220/wnj.v04.s2.0001.
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The rate of Caesarean delivery is rising dramatically worldwide, and also nationally. The number of Caesarean births exceeds the WHO recommended rate. This study aims to provide an overview of current increasing trend of Caesarean section, including elective procedure, and its risk. A review was conducted using online database, surveillance reports, and national surveys to identify studies with topics of prevalence, trend, indications, and risks of Caesarean delivery. Overall, there is an increase of Caesarean section in global, Asia, and Indonesia setting. We found an increase of 8% from 2013 to 2018 based on population survey, and increase of elective Caesarean surgery, particularly in tertiary care. We listed the possible health risks in short term, long term among mothers and child. Advanced maternal age, higher socio-economic status, higher educational level, residing in urban area, and ownership of health insurance were found to be factors associated with maternal choice on Caesarean delivery. The information presented is important to raise awareness among policy makers aimed to develop a national strategy in reducing the rate of Caesarean delivery.
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Sadiq, Ahmad, and Terati Terati. "NUTRITION EDUCATION AND HEALTH SERVICES IN YOUTH ANEMIA PREVENTION AT SMA NEGERI 11 PALEMBANG." Abdi Dosen : Jurnal Pengabdian Pada Masyarakat 7, no. 1 (March 7, 2023): 101. http://dx.doi.org/10.32832/abdidos.v7i1.1493.
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Adolescence (10-18 years) is a period of nutritional vulnerability due to various reasons. Some research data shows that there are still nutritional problems in adolescents in Indonesia, especially the problem of nutritional anemia. The results of the 2018 Riskesdas research state that the cause of the high prevalence of nutritional anemia in adolescent girls is that they tend to go on a diet so that they can reduce their intake of nutrients, including iron. In addition, the existence of a monthly menstrual cycle is one of the factors that cause young women to be susceptible to iron deficiency anemia. Based on this, community service activities were carried out in the form of nutrition education activities (counseling) and health services in preventing anemia in adolescent girls at SMA Negeri 11 Palembang. This community service is carried out in 2 stages of activities, namely nutrition education in the form of counseling, as well as conducting health service activities in the form of screening by capturing students who have less or more nutritional status and students with indications of anemia. From anthropometric measurements, we get Most of the 60% of students with normal nutritional status for very thin and thin nutritional status were 16.7% and 3.3%, while those with nutritional status were fat and very fat as much as 6.7% and 13.3%, respectively. The results of the Hb examination showed that most of the students (66.7%) did not have anemia (Normal Hb), there were (20.%) students with moderate anemia status, and (13.3%) with mild anemia status. An increase in students' knowledge of 18.17 points after the post-test. In addition, this community service activity is expected to increase knowledge of nutrition and health, especially regarding anemia in adolescents and how to treat it.
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Whalen, D. H., Margaret Moss, and Daryl Baldwin. "Healing through language: Positive physical health effects of indigenous language use." F1000Research 5 (May 9, 2016): 852. http://dx.doi.org/10.12688/f1000research.8656.1.
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This article summarizes existing work that indicates language maintenance and revitalization efforts result in health-related benefits for Native Americans and other indigenous populations. Although forced loss of ancestral language has been a feature of life in most indigenous communities since the first contact with Europeans, the pace of loss has accelerated in the past 50 years. Among the many hardships such communities face, an especially troubling one is lowered health status. There are indications, however, that language maintenance and revitalization efforts have positive effects on physical and communal health among indigenous populations. The types of language programs currently in place are outlined along with a variety of studies that will measure health improvement outcomes correlated with language revitalization efforts. Such evidence justifies increased support for language revitalization in order to improve health.
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Shpak, N., I. Boldi, and I. Maze-Launay. "Effectiveness of the electric shock treatment on the old age patients." European Psychiatry 26, S2 (March 2011): 857. http://dx.doi.org/10.1016/s0924-9338(11)72562-7.
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The authors analyse 17 cases of electric shock treatment performed in the over 70th years old patients. They observe the effectiveness on affective status, the cognitive performance and the patient's autonomy. These items and the treatment's tolerance are measured before and after the treatment by a standardized geriatric assessment.The standardized geriatric assessment as an objective measure permit to put the target's indications and to monitorize the maintain of the benefits with electric shock treatment.
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Alsafadi, Danyah Mahmoud, Gaida Sharaf Alzahrani, Qasem Mohammed Alhayek, Hawra Hassan Alghazwi, Waleed Abdulwahab Alzahrani, Reema Saeed AL Qahtani, Afnan Jaber Alfahhad, et al. "Indications and long-term results of enteral feeding in infancy and childhood." International Journal Of Community Medicine And Public Health 9, no. 1 (December 27, 2021): 399. http://dx.doi.org/10.18203/2394-6040.ijcmph20214795.
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Enteral feeding is more favorable than parenteral one because it can significantly intervene against the colonization of bacteria and preserve gut functions. However, this necessitates the presence of a good-functioning gastrointestinal tract. Young infants, critically ill children, and patients with neurological disabilities are the most probable candidates to perform enteral feeding. In the present literature review, we have discussed the indications and long-term results of enteral feeding in pediatric settings. Our results show that modality is a safe and efficacious modality in these settings with favorable outcomes and fewer adverse events and complications. Many indications were reported for the modality, and in general, children that usually suffer from severe weight deficit, weight faltering, and growth retardation are indicated to receive enteral nutrition. Some contraindications were also reported in the literature, and in general, conditions affecting the function and health status gastrointestinal tract should recommend against conducting approaches of enteral feeding. Different complications were reported, including mechanical, metabolic, infectious, gastrointestinal, and drug-related complications that might lead to worsened prognosis and can significantly impact the long-term outcomes of these patients. Therefore, paying adequate attention should be considered in these cases to prevent the development of these complications, and provide all the necessary procedures to potentially manage the expected adverse events.
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Dhakal-Rai, Sulochana, Edwin van Teijlingen, Pramod Raj Regmi, Juliet Wood, Ganesh Dangal, and Keshar Bahadur Dhakal. "Factors contributing to rising cesarean section rates in South Asian countries: A systematic review." Asian Journal of Medical Sciences 13, no. 2 (February 1, 2022): 143–74. http://dx.doi.org/10.3126/ajms.v13i2.40904.
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Rising cesarean section (CS) rates are a global public health problem. The systematic review investigates key indications for performing CS and factors significantly associated with the rising rate of CS in South Asia. Primary studies in South Asia published between January 2010 and December 2018 were searched using relevant electronic databases: MEDLINE, Scopus, PubMed, Web of Science, CINAHL, NepJOL, and BanglaJOL. A narrative synthesis of the indications for performing CS and factors significantly associated with the rising CS rates was performed using content analysis. A total of 68 studies were included in this review. The most common medical indication for CS was fetal distress, followed by previous CS, antepartum hemorrhage (including placenta previa/abruption), cephalopelvic disproportion, failed induction, hypertensive disorders in pregnancy, oligohydramnios, and non-progress of labor. Maternal request was the most common non-medical indication for conducting CS. Higher maternal age was the most common significant factor associated with the rising CS rate followed by higher maternal education, urban residency, higher economic status, previous CS, pregnancy/childbirth complications, and lower parity/nulliparity. Preference for CS and increasing private number hospital were also factors contributing to the rising rate. Several key indicators and factors significantly associated with rising CS rate are revealed. These key indicators and significant factors reflect the global trend. Reduction in the use of primary CS, unless medically warranted, would help stem rates of CS. Realistic and candid explanation to pregnant women and their families regarding the benefits of vaginal birth for women and babies should form an integral part of maternity care as these are issues of public health.
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Whelan, Harry T., and Ann K. Helms. "Hyperbaric oxygen for neurologic indications. Action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy and status migrainosus." Pediatria Polska 87, no. 5 (September 2012): 429–37. http://dx.doi.org/10.1016/j.pepo.2012.08.001.
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Shree, Vidya, and Sharanabasappa. "WEARABLE REAL TIME HEALTH TRACKERS AND ASSISTED-MOBILITY FOR NON-AMBULANT PATIENTS." International Journal of Research -GRANTHAALAYAH 5, no. 4RACSIT (April 30, 2017): 41–46. http://dx.doi.org/10.29121/granthaalayah.v5.i4racsit.2017.3349.
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This paper presents an approach to facilitate mobility for the non-ambulant patients using eye movements and wearable health tracking. The patient’s wheelchair movement is controlled using eye ball movements and also some biomedical assistance functionalities are considered to match the current day needs. The proposed work first detects face from input video, then eye portion will be localized, and finally eye ball (pupil) is detected and tracked using computer vision techniques. The direction of movement is assessed and a command is disseminated to the wheelchair control system. The wearable sensors and\or alarms mounted on patients will update current health status indications on to the monitoring panels. The wearable devices have evolved very smartly which are capable enough to take care of the patient health in real time even during assisted mobility.
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Malnick, Stephen D. H., David Fisher, Marina Somin, and Manuela G. Neuman. "Treating the Metabolic Syndrome by Fecal Transplantation—Current Status." Biology 10, no. 5 (May 20, 2021): 447. http://dx.doi.org/10.3390/biology10050447.
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The intestinal microbiome (IM) is important for normal gastrointestinal (GI) and other organ systems’ functioning. An alteration in the normal IM, dysbiosis, and changes in intestinal motility result in microorganisms’ overgrowth and an alteration in intestinal permeability. The gut–brain axis is also of importance in the irritable bowel syndrome (IBS) and associated bowel overgrowth. Secondary to the epidemic of obesity, the metabolic syndrome has become a major health problem. Disturbances in the fecal microbiome are associated with the metabolic syndrome. Metabolic-associated fatty liver disease (MAFLD) is now the current terminology for non-alcoholic fatty liver disease. IM alteration by fecal transplantation is an approved treatment method for recurrent Clostridioides difficile infection. Initially performed by either duodenal infusion or colonoscopy, it is now easily performed by the administration of capsules containing stools. We discuss the intestinal microbiome—its composition, as well as the qualitative changes of microbiome composition leading to inflammation. In addition, we discuss the evidence of the effect of fecal transplantation on the metabolic syndrome and MAFLD, as well as its clinical indications.
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Kroth, Elmar. "Switch – The German process for moving medicines from prescription to non-prescription status." Gesundheitsökonomie & Qualitätsmanagement 23, no. 02 (July 20, 2017): 97–102. http://dx.doi.org/10.1055/s-0043-115561.
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Abstract Background Germany has a long tradition of switch and has long been considered one of the most liberal countries in terms of the release of modern active substances from prescription, the so-called switch. In the period 2000–2016, a total of more than 30 active ingredients – partly in different dosage strengths, dosage forms or indications – were released from prescription status in Germany. Of these, almost half can be described as “innovative” switches. Recently a significant decline of filed switch proposals can be noted, with only a few being successful. Methods Reflecting that the German switch procedure is barely mentioned in the literature it is the aim of this article to describe the German approach. The legal framework in the national and European Legislation are assessed as well as the experience of the author and his predecessor over more than 35 years of membership in the German Switch Committee were described. Results Although the German switch procedure is based on European legislation a successful switch application demands insights in the national particularities. The process is complex and partly intransparent. After a phase of restraint there are positive developments recently particularly the possibility for a scientific advice in pre-submission meetings.