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Humphrey Beebe, Lora, and Sheila White. "Depression Sourcebook: Health Reference Series, 2nd edition." Issues in Mental Health Nursing 30, no. 12 (November 10, 2009): 806. http://dx.doi.org/10.3109/01612840903230099.
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Gunnels, Maggi. "Head trauma sourcebook. Vol. 23 (Health reference series)." Journal of Emergency Nursing 24, no. 2 (April 1998): 153–54. http://dx.doi.org/10.1016/s0099-1767(98)90019-8.
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Vogelzang, Jody L. "Health Reference Series: Diet and Nutrition Sourcebook, 2nd Edition." Home Healthcare Nurse 18, no. 5 (May 2000): 341. http://dx.doi.org/10.1097/00004045-200005000-00023.
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Yun, Zhonghua, Wenhu Qin, Weipeng Shi, and Peng Ping. "State-of-Health Prediction for Lithium-Ion Batteries Based on a Novel Hybrid Approach." Energies 13, no. 18 (September 16, 2020): 4858. http://dx.doi.org/10.3390/en13184858.
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Generally, the State-of-Health (SOH) monitoring and Remaining Useful Life (RUL) prediction and assessment of lithium-ion (Li-ion) batteries need to use sensors to obtain the degradation test data of the same type of batteries and establish the degradation model for reference. However, when the battery type is unknown, a usable reference model cannot be obtained, so its prediction and evaluation may be relatively inconvenient. In this paper, the State of-Health prediction for lithium-ion batteries based on a novel hybrid scheme is proposed. Firstly, historical charge/discharge time series and capacity series are extracted to analyze and construct Health Indicators, then using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) to decompose the Health Indicator series into the trend and non-trend terms. Among them, the relatively smooth trend item data series uses the Autoregressive Integrated Moving Average model (ARIMA) for prediction; when dealing with the data series of non-trend items which are obviously non-smooth and seemingly random, the residuals predicted by ARIMA and the non-trend items obtained by CEEMDAN decomposition are combined into new non-trend items; then the least square support vector machine (LSSVM) is introduced to build a nonlinear prediction model and make predictions. Finally, combining the prediction results of the trend item data series and the non-trend item data series as a reference for the assessment of the state of health and remaining useful life. The 13 experimental results of 3 batteries verify the effectiveness of the scheme.
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Breuer, Dietmar, Katrin Pitzke, Franziska Nürnberger, Jana Poprizki, Christian Monse, Christian Monz, and Cornelia Wippich. "30 Reference Materials for the Measurement of Metals in Workplace Air." Annals of Work Exposures and Health 67, Supplement_1 (May 1, 2023): i5. http://dx.doi.org/10.1093/annweh/wxac087.014.
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Abstract For the production of filters coated with metal oxides an aqueous metal salt solution is injected into a hydrogen/oxygen flame of a particle generator leading to the pyrolysis of the metal salts into nano-scaled metal oxide dust. The particles are introduced into a large sampling chamber (20 m³) via a dust tunnel (20 m). So far, the system was tested for Zn, Cu, Pb, Co, Ni, Mn and In but it should be suitable with all metals obtainable as soluble metal salts. For sample generation an eight-fold sampling system was developed for the GSP sampler. The constancy of the flow rate is assured by critical orifices. Up to fourteen of these systems can be operated to produce 112 samples in parallel. Nevertheless, for the production of a reference material a significantly higher number of samples will be needed. To achieve this aim the environmental conditions of the dust generation have to be stabilized for consecutive runs. The major problem was the temperature rise of the dust channel during the particle generation due to the heat of the flame. An additional heater was installed to work at a constant temperature of 30 °C. Three consecutive filter series were manufactured. The achieved temperature constancy of 30± 0.5 °C makes it possible to combine the successive filter series. The loadings of the combined series were Cobalt: 3.25±0.058 µg/filter, Nickel: 13.78±0.23 µg/filter, Lead: 109.5±3.0, Copper: 9.65 ±0.18 µg/filter and Zinc: 32.66±0.72 µg/filter.
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Zhou, Ru-Yi, Yinzhu Zhou, Heng Zhang, Qingqing Hu, Jinjie Zhu, Jin Zhao, Shuilian Chen, et al. "Public health concerns regarding sporadic Creutzfeldt–Jakob disease in China: a case series." Journal of International Medical Research 47, no. 8 (July 23, 2019): 3972–77. http://dx.doi.org/10.1177/0300060519862067.
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In this study, we report three cases of sporadic Creutzfeldt–Jakob disease in China, two confirmed cases and one probable case. The aim of this study was to enrich the data regarding clinical and epidemiological features of this disease and to provide reference for the diagnosis, control, and prevention of sporadic Creutzfeldt–Jakob disease.
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Ding, Xiaoxi, Liming Wang, Wenbin Huang, Qingbo He, and Yimin Shao. "Feature Clustering Analysis Using Reference Model towards Rolling Bearing Performance Degradation Assessment." Shock and Vibration 2020 (March 28, 2020): 1–14. http://dx.doi.org/10.1155/2020/6306087.
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The health monitoring and management have been accepted in modern industrial machinery for an intelligent industrial production. To timely and reliably assess the bearing performance degradation, a novel health monitoring method called feature clustering analysis (FCA) has been proposed in this study. Along with the working time going, this new monitored chart picked by FCA aims to describe the feature clustering distribution transition by a series of reference models. First, the data provided by the reference state (healthy data) and the one from the monitor state (monitor data) are fused together to construct a reference model, which is to explore the active role of healthy status and activate the difference between healthy status and unhealthy status. Manifold learning is later implemented to mine the discriminated features for good class-separable clustering measure. In this manner, heterogeneous information hidden in this reference model will appear once degradation happened. Finally, a clustering quantification factor, named as feature clustering indicator (FCI), is calculated to assess distribution evolution and migration of the monitor status as compared to the consistent healthy status. Furthermore, a single Gaussian model (SGM) based on these FCIs is used to provide a smooth estimate of the healthy condition level. The corresponding negative log likelihood probability (NLLP) and the fault occurrence alarm are developed for an accurate and reliable FCC. And it can well depict a comprehensibility of the real bearing performance degradation process for its whole life. Meanwhile, as compared to other health profiles based on the classical health indicators, the proposed FCC has provided a much more accurate degradation level and rather monotonic profile. The experimental results show the potential in machine health performance degradation assessment.
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Sprochi, Amanda K. "Book Review: The Opioid Crisis: A Reference Handbook." Reference & User Services Quarterly 58, no. 3 (June 22, 2019): 195. http://dx.doi.org/10.5860/rusq.58.3.7059.
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The opioid crisis has been a topic of much concern for much of the last decade, and it has reached epidemic proportions in the United States. The CDC estimates that 115 people per day die from overdosing on opioids, and countless articles, news stories, social media accounts, and television programs have documented the destruction. This latest volume in ABC-CLIO’s Contemporary World Issues series, authored by David E. Newsome, a prolific writer with an EdD in science education, tackles the history, epidemiology, and controversies surrounding the twenty-first century public health crisis.
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Che, Chun-Tao, and Hongjie Zhang. "Plant Natural Products for Human Health." International Journal of Molecular Sciences 20, no. 4 (February 15, 2019): 830. http://dx.doi.org/10.3390/ijms20040830.
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The aim of this Special Issue on “Plant Natural Products for Human Health” is to compile a series of scientific reports to demonstrate the medicinal potential of plant natural products, such as in vitro and in vivo activities, clinical effects, mechanisms of action, structure-activity relationships, and pharmacokinetic properties. With the global trend growing in popularity for botanical dietary supplements and phytopharmaceuticals, it is hoped that this Special Issue would serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.
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Jesus, G., J. Gama Marques, and R. Durval. "EPA-0909 – A review of olfactory reference syndrome about a series of clinical cases." European Psychiatry 29 (2014): 1. http://dx.doi.org/10.1016/s0924-9338(14)78234-3.
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Akerstrom, M., J. Severin, H. Imberg, I. H. Jonsdottir, L. Björk, and L. Corin. "Methodological approach for measuring the effects of organisational-level interventions on employee withdrawal behaviour." International Archives of Occupational and Environmental Health 94, no. 7 (March 26, 2021): 1671–86. http://dx.doi.org/10.1007/s00420-021-01686-y.
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Abstract Background Theoretical frameworks have recommended organisational-level interventions to decrease employee withdrawal behaviours such as sickness absence and employee turnover. However, evaluation of such interventions has produced inconclusive results. The aim of this study was to investigate if mixed-effects models in combination with time series analysis, process evaluation, and reference group comparisons could be used for evaluating the effects of an organisational-level intervention on employee withdrawal behaviour. Methods Monthly data on employee withdrawal behaviours (sickness absence, employee turnover, employment rate, and unpaid leave) were collected for 58 consecutive months (before and after the intervention) for intervention and reference groups. In total, eight intervention groups with a total of 1600 employees participated in the intervention. Process evaluation data were collected by process facilitators from the intervention team. Overall intervention effects were assessed using mixed-effects models with an AR (1) covariance structure for the repeated measurements and time as fixed effect. Intervention effects for each intervention group were assessed using time series analysis. Finally, results were compared descriptively with data from process evaluation and reference groups to disentangle the organisational-level intervention effects from other simultaneous effects. Results All measures of employee withdrawal behaviour indicated statistically significant time trends and seasonal variability. Applying these methods to an organisational-level intervention resulted in an overall decrease in employee withdrawal behaviour. Meanwhile, the intervention effects varied greatly between intervention groups, highlighting the need to perform analyses at multiple levels to obtain a full understanding. Results also indicated that possible delayed intervention effects must be considered and that data from process evaluation and reference group comparisons were vital for disentangling the intervention effects from other simultaneous effects. Conclusions When analysing the effects of an intervention, time trends, seasonal variability, and other changes in the work environment must be considered. The use of mixed-effects models in combination with time series analysis, process evaluation, and reference groups is a promising way to improve the evaluation of organisational-level interventions that can easily be adopted by others.
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Woźniak, Zuzanna Zofia, Adrian Chajec, and Łukasz Sadowski. "Effect of the Partial Replacement of Cement with Waste Granite Powder on the Properties of Fresh and Hardened Mortars for Masonry Applications." Materials 15, no. 24 (December 19, 2022): 9066. http://dx.doi.org/10.3390/ma15249066.
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Granite is a well-known building and decorative material, and, therefore, the amount of produced waste in the form of granite powder is a problem. Granite powder affects the health of people living near landfills. Dust particles floating in the air, which are blown by gusts of wind, can lead to lung silicosis and eye infections, and can also affect the immune system. To find an application for this kind of waste material, it was decided to study the effect of partially replacing cement with waste granite powder on the properties of fresh and hardened mortars intended for masonry applications. The authors planned to replace 5%, 10%, and 15% of cement with waste material. Series of mortar with the addition of granite powder achieved 50% to 70% of the compressive strength of the reference series, and 60% to 76% of the bending strength of the reference series. The partial replacement of cement with the granite powder significantly increased the water sorption coefficient. The consistency of the fresh mortar, and its density and water absorption also increased when compared to the reference series. Therefore, Granite powder can be used as a partial replacement of cement in masonry mortars.
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Peng, Linfeng. "Prediction of Oral Cancer Incidence in Hunan Using a Time-Series Prediction Model Based on Logistic Regression Modeling." Highlights in Science, Engineering and Technology 92 (April 10, 2024): 257–63. http://dx.doi.org/10.54097/5mp06574.
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Scientific and reliable prediction of the incidence of oral cancer is very meaningful, which can assist the medical industry to carry out effective prevention and treatment measures, and also serve as a reference and basis for the formulation of related health policies. Therefore, this paper mainly explores the prediction method based on the Logistic Regression model to predict and analyze the number of oral cancer incidences. The study in this paper found that age, gender, and betel nut consumption were associated with the incidence of oral cancer. Among them, males and middle-aged and older age groups were more susceptible. The time-series prediction indicates that the model accurately predicts oral cancer incidence in multifactorial samples, which provides effective preventive and curative measures for the healthcare industry and serves as a basis for health policy. Future studies can improve the accuracy through comprehensive data collection and advanced model optimization. The results of the study provide a reference for early prevention and intervention of oral cancer, which can help formulate health policies to serve public health and individual health.
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Choi, Chansoo, Bangho Shin, Yeon Soo Yeom, Thang Tat Nguyen, Haegin Han, Sangseok Ha, Beom Sun Chung, Wesley E. Bolch, and Chan Hyeong Kim. "Development of paediatric mesh-type reference computational phantom series of International Commission on Radiological Protection." Journal of Radiological Protection 41, no. 3 (August 19, 2021): S160—S170. http://dx.doi.org/10.1088/1361-6498/ac0801.
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Candelieri, Antonio, Stanislav Fedorov, and Enza Messina. "Efficient Kernel-Based Subsequence Search for Enabling Health Monitoring Services in IoT-Based Home Setting." Sensors 19, no. 23 (November 27, 2019): 5192. http://dx.doi.org/10.3390/s19235192.
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This paper presents an efficient approach for subsequence search in data streams. The problem consists of identifying coherent repetitions of a given reference time-series, also in the multivariate case, within a longer data stream. The most widely adopted metric to address this problem is Dynamic Time Warping (DTW), but its computational complexity is a well-known issue. In this paper, we present an approach aimed at learning a kernel approximating DTW for efficiently analyzing streaming data collected from wearable sensors, while reducing the burden of DTW computation. Contrary to kernel, DTW allows for comparing two time-series with different length. To enable the use of kernel for comparing two time-series with different length, a feature embedding is required in order to obtain a fixed length vector representation. Each vector component is the DTW between the given time-series and a set of “basis” series, randomly chosen. The approach has been validated on two benchmark datasets and on a real-life application for supporting self-rehabilitation in elderly subjects has been addressed. A comparison with traditional DTW implementations and other state-of-the-art algorithms is provided: results show a slight decrease in accuracy, which is counterbalanced by a significant reduction in computational costs.
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Iñiguez, I. Cuevas, M. D. C. Molina Lietor, and I. Moreno Alonso. "Culture and personality disorders-a case series." European Psychiatry 64, S1 (April 2021): S679. http://dx.doi.org/10.1192/j.eurpsy.2021.1801.
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IntroductionPersonality disorders comprise a set of diagnosis characterized by inflexible, pervasive and enduring patterns of cognition, affect, behavioural and social interaction. The status of research on the personality among different cultures implies the universality of traits and disorders, as well as, their measuresacross cultures.ObjectivesTo study the prevalence of personality disorders in foreigner patients.MethodsIn this retrospective case series, clinicaldata was collected from 40 patients who were hospitalized at the short-stay inpatient psychiatric service of the Príncipe de Asturias University Hospital during 2018.ResultsNineteen (47.5%) patients were European, ten (25%) were from South America, nine (22.5%) were Africanand two (5%) were Asian. Eight patients were diagnosed of diverse personality disorders. Seven (87.5%) of them were European, and only one (12.5%) was from South America.ConclusionsThis case series suggests various directions for future research. The fact that patients diagnosed with personalitydisorders were mainly European could indicate diverse conclusions. It would question the universality of personality disorders out of a Euro-american frame of reference. It would also point out the difficulty of diagnosing personality disorders, taking into consideration language, awareness of cultural values,traditions, interactional patterns, and social norms. More studies of traits and personality are needed, taking into account the culture and the society in which patients have grown and in which they currently live.DisclosureNo significant relationships.
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Bondarenko, Valeria, Pierre Mazzega, and Claire Lajaunie. "Predictability of Scrub Typhus Incidences Time Series in Thailand." Engineering Proceedings 5, no. 1 (July 13, 2021): 44. http://dx.doi.org/10.3390/engproc2021005044.
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Scrub typhus, an infectious disease caused by a bacterium transmitted by “chigger” mites, constitutes a public health problem in Thailand. Predicting epidemic peaks would allow implementing preventive measures locally. This study analyses the predictability of the time series of incidence of scrub typhus aggregated at the provincial level. After stationarizing the time series, the evaluation of the Hurst exponents indicates the provinces where the epidemiological dynamics present a long memory and are predictable. The predictive performances of ARIMA (autoregressive integrated moving average model), ARFIMA (autoregressive fractionally integrated moving average) and fractional Brownian motion models are evaluated. The results constitute the reference level for the predictability of the incidence data of this zoonosis.
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Zhang, Yanli, Xinmiao Li, Yu Yang, and Tao Wang. "Disease- and Drug-Related Knowledge Extraction for Health Management from Online Health Communities Based on BERT-BiGRU-ATT." International Journal of Environmental Research and Public Health 19, no. 24 (December 9, 2022): 16590. http://dx.doi.org/10.3390/ijerph192416590.
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Knowledge extraction from rich text in online health communities can supplement and improve the existing knowledge base, supporting evidence-based medicine and clinical decision making. The extracted time series health management data of users can help users with similar conditions when managing their health. By annotating four relationships, this study constructed a deep learning model, BERT-BiGRU-ATT, to extract disease–medication relationships. A Chinese-pretrained BERT model was used to generate word embeddings for the question-and-answer data from online health communities in China. In addition, the bidirectional gated recurrent unit, combined with an attention mechanism, was employed to capture sequence context features and then to classify text related to diseases and drugs using a softmax classifier and to obtain the time series data provided by users. By using various word embedding training experiments and comparisons with classical models, the superiority of our model in relation to extraction was verified. Based on the knowledge extraction, the evolution of a user’s disease progression was analyzed according to the time series data provided by users to further analyze the evolution of the user’s disease progression. BERT word embedding, GRU, and attention mechanisms in our research play major roles in knowledge extraction. The knowledge extraction results obtained are expected to supplement and improve the existing knowledge base, assist doctors’ diagnosis, and help users with dynamic lifecycle health management, such as user disease treatment management. In future studies, a co-reference resolution can be introduced to further improve the effect of extracting the relationships among diseases, drugs, and drug effects.
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Lara, J. A., L. Martinez, A. Pérez, J. P. Valente, and F. Alonso. "Generating Reference Models for Structurally Complex Data." Methods of Information in Medicine 52, no. 05 (2013): 441–53. http://dx.doi.org/10.3414/me12-01-0106.
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SummaryObjectives: We present a framework specially designed to deal with structurally complex data, where all individuals have the same structure, as is the case in many medical domains. A structurally complex individual may be composed of any type of single-valued or multivalued attributes, including time series, for example. These attributes are structured according to domain-dependent hierarchies. Our aim is to generate reference models of population groups. These models represent the population archetype and are very useful for supporting such important tasks as diagnosis, detecting fraud, analyzing patient evolution, identifying control groups, etc.Methods: We have developed a conceptual model to represent structurally complex data hierarchically. Additionally, we have devised a method that uses the similarity tree concept to measure how similar two structurally complex individuals are, plus an outlier detection and filtering method. These methods provide the groundwork for the method that we have designed for generating reference models of a set of structurally complex individuals. A key idea of this method is to use event-based analysis for modeling time series.Results: The proposed framework has been applied to the medical field of stabilometry. To validate the outlier detection method we used 142 individuals, and there was a match between the outlier ratings by the experts and by the system for 139 individuals (97.8%). To validate the reference model generation method, we applied k-fold cross validation (k = 5) with 60 athletes (basket-ball players and ice-skaters), and the system correctly classified 55 (91.7%). We then added 30 non-athletes as a control group, and the method output the correct result in a very high percentage of cases (96.6%).Conclusions: We have achieved very satisfactory results for the tests on data from such a complex domain as stabilometry and for the comparison of the reference model generation method with other methods. This supports the validity of this framework.
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Sharpless, Katherine E., David L. Anderson, Joseph M. Betz, Therese A. Butler, Stephen G. Capar, John Cheng, Catharine A. Fraser, et al. "Preparation and Characterization of a Suite of Ephedra-Containing Standard Reference Materials." Journal of AOAC INTERNATIONAL 89, no. 6 (November 1, 2006): 1483–95. http://dx.doi.org/10.1093/jaoac/89.6.1483.
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Abstract The National Institute of Standards and Technology, the U.S. Food and Drug Administration, Center for Drug Evaluation and Research and Center for Food Safety and Applied Nutrition, and the National Institutes of Health, Office of Dietary Supplements, are collaborating to produce a series of Standard Reference Materials (SRMs) for dietary supplements. A suite of ephedra materials is the first in the series, and this paper describes the acquisition, preparation, and value assignment of these materials: SRMs 3240 Ephedra sinica Stapf Aerial Parts, 3241 E. sinica Stapf Native Extract, 3242 E. sinica Stapf Commercial Extract, 3243 Ephedra-Containing Solid Oral Dosage Form, and 3244 Ephedra-Containing Protein Powder. Values are assigned for ephedrine alkaloids and toxic elements in all 5 materials. Values are assigned for other analytes (e.g., caffeine, nutrient elements, proximates, etc.) in some of the materials, as appropriate. Materials in this suite of SRMs are intended for use as primary control materials when values are assigned to in-house (secondary) control materials and for validation of analytical methods for the measurement of alkaloids, toxic elements, and, in the case of SRM 3244, nutrients in similar materials.
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Singh, Avinash C., and Christopher D. Bilsbury. "Measuring Levels of Experiential States in Clinical Applications by Discan: A Discretized Analog Method." Behavioural Psychotherapy 17, no. 1 (January 1989): 27–41. http://dx.doi.org/10.1017/s0141347300015615.
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A clinically-oriented description is provided of the Discretized Analog or Discan method (Singh and Bilsbury, 1984) for obtaining reliable and precise measures of subjectively experienced dysfunction variables whose possible values form a continuum. The method can provide a 14-point ordered categorical scale with only four reference levels which represent some of the possible values of intensity of the variable. The process of Discan administration consists of a series of repeated comparisons of the true or perceived level with one or two reference levels at a time. It therefore allows for use of elaborate descriptive statements for reference levels. It is recommended following Shapiro (1961, 1975) that the reference levels be ideographic, ipsitive and should reflect ordered steps of recovery from the dysfunction. Discan overcomes several limitations of the commonly used rating scales. An application of Discan to the MSB relaxation technique is presented as an illustration.
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Buteau, Jacques, Alain D. Lesage, and Margaret C. Kiely. "Homicide Followed by Suicide: A Quebec Case Series, 1988–1990." Canadian Journal of Psychiatry 38, no. 8 (October 1993): 552–56. http://dx.doi.org/10.1177/070674379303800805.
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Homicide followed by suicide is a rare but tragic event. Psychiatrists and mental health professionals are often called upon to comment publicly on the event or to help the “hidden victims,” the survivors of the tragedy. There were 39 such cases in Quebec between 1988 and 1990, and they have been reviewed through the examination of the coroner's files. The epidemiological rates of homicide, suicide, homicide-suicide and the sociodemographic and clinical characteristics of the perpetrators and victims are presented and compared with the international literature. Sociological and psychopathological hypotheses are presented with a special reference to the possibility of various subgroups of perpetrators. Research needs to be pursued along the lines of more detailed case studies of psychopathological characteristics using the psychological autopsy approach. The reconstruction of the couple's relationship and of the final circumstances leading up to the tragedy may provide warning indices that could be helpful in preventing such tragedies.
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Goita, Daouda, Sylla Mala, Coulibaly Ousmane, Sidibe Moro, Maiga O. Ahmadou, Malle Sékou, Sidibe Mamadou Kolé, et al. "Management of Corneal Perforation by Conjunctival Covering at the Bougouni Reference Health Center: A Series of Five (5) Cases." Scholars Journal of Applied Medical Sciences 11, no. 06 (June 23, 2023): 1141–45. http://dx.doi.org/10.36347/sjams.2023.v11i06.026.
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Introduction: Corneal perforations are a major cause of ocular morbidity and blindness. Several surgical techniques can be used to treat them, including conjunctival covering, which has numerous therapeutic properties and reduces the risk of anatomical loss. Observation: We present a series of five (5) cases admitted to the ophthalmology department for ocular pain, in whom the clinical examination concluded a corneal perforation. The etiologies were traumatic in three patients, Mooren's ulcer in one and undetermined in another. Conjunctival covering was the technique used to manage the patients. Visual acuity improved in two of our patients after surgery, and remained almost unchanged in one. Two patients were lost to follow-up. Conclusion: Despite the advancement and promotion of new techniques, conjunctival covering still has its place in the management of corneal perforations, especially when the technical platform is weak.
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McArthur, J., J. Bolles, J. Fine, P. Kidd, and M. Bessis. "Interactive Computer-Video Modules for Health Sciences Education." Methods of Information in Medicine 28, no. 04 (October 1989): 360–63. http://dx.doi.org/10.1055/s-0038-1636797.
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Abstract:Advances in electronic image recording and computer technologyhave resulted in a remarkable increase in the power and flexibility of interactive computer-video teaching systems. The University of Washington Health Science Videodisc Development Group first demonstrated a laser videodisc controlled by a remote central computer in 1980. Even this rudimentary unit highlighted basic medical informatics principles including: rapid accessibility; a “generic” or multi-purposed format; ease of computer control; and large collections of valid, rigorously reviewed images. Advances in medical informatics have led to the development of the following previously undescribed series of teaching units:1. The hypertext programs Hypercard, Linkway, and Guide have been used with videodiscs to develop easy-to-use instructional and reference materials. These materials demonstrate the ease with which a computer-naive instructor may develop new programs and the advantage that the intuitive nature of these programs brings to student users.2. Patient simulations using single and double screens plus pre-defined knowledge structures;3. Interactive single topic tutorials using preset knowledge structures;4. A key-word-based disc searching system;5. Electronic video microscopy;6. A series of programs developed independently by health science faculty who have purchased multi-purpose videodiscs that demonstrate the flexibility of the multi-purpose or “generic”: collection concept.
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Oyama-Higa, Mayumi, and Fumitake Ou. "Indication of Mental Health from Fingertip Pulse Waves and Its Application." Journal of Healthcare Engineering 2018 (October 17, 2018): 1–17. http://dx.doi.org/10.1155/2018/7696458.
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This article is a comprehensive review of recent studies of the authors on the indication of mental health from biological information contained in pulse waves. A series of studies discovered that the largest Lyapunov exponent (LLE) of the attractor, which is constructed for the time series data from pulse waves, can provide as an effective indicator of mental health. A low level of LLE indicates insufficiency of external adaptability, which is characteristic of dementia and depression sufferers. On the contrary, a continuous high level of LLE indicates excessive external adaptability, and people in this condition tend to resort to violence. With this discovery, real-time display of the LLE, combined with other physiological indexes such as the autonomic nerve balance (ANB), sample entropy, and vascular age, as a reference, can enable people to conduct self-check of mental status. To this end, software development was performed in order to enable users to conduct pulse wave measurement anywhere at any time and display the analytical results in real time during the measurement.
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Rossow, Ingeborg. "Regional Analyses of Alcohol and Suicide in Norway: Some Empirical Considerations." Suicide and Life-Threatening Behavior 25, no. 3 (September 1995): 401–9. http://dx.doi.org/10.1111/j.1943-278x.1995.tb00963.x.
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The association between alcohol consumption and suicide was analyzed on aggregate‐level data from Norway, applying regional units in the analyses. Thereby two purposes could be served: to validate previous estimates derived from time series analyses, and to assess an empirical indication of alcohol and suicide as alternative solutions. The effect of alcohol consumption on suicide rates tended to be higher for women than for men, which is contrary to results from time series analyses and what might generally be expected. The results are discussed with reference to causal mechanisms and alcohol and suicide as alternative choices of action, and methodological considerations are outlined.
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Furlan, Fernanda Luiza Schumacher, Macleise Andres Lemes, Ligia Cecilia Fuverki Suguimatsu, Carolina Teixeira Furquim Pires, and Mara Lucia Schmitz Ferreira Santos. "X-LINKED ADRENOLEUKODYSTROPHY IN BRAZIL: A CASE SERIES." Revista Paulista de Pediatria 37, no. 4 (December 2019): 465–71. http://dx.doi.org/10.1590/1984-0462/;2019;37;4;00015.
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ABSTRACT Objective: To describe patients with different phenotypes of X-linked adrenoleukodystrophy: pre-symptomatic, cerebral demyelinating inflammatory adrenoleukodystrophy, adrenomyeloneuropathy and adrenal insufficiency only. Methods: Specific data related to epidemiology, phenotype, diagnosis and treatment of 24 patients with X-linked adrenoleukodystrophy were collected. A qualitative cross-sectional and descriptive-exploratory analysis was performed using medical records from a reference center in Neuropediatrics in Curitiba, Brazil, as well as an electronic questionnaire. Results: The majority (79%) of patients had cerebral demyelinating inflammatory adrenoleukodystrophy, presenting aphasia, hyperactivity and vision disorders as the main initial symptoms. These symptoms appeared, on average, between six and seven years of age. There was a mean delay of 11 months between the onset of symptoms/signs and the diagnosis. Patients sought diagnosis mainly with neuropediatricians, and the main requested tests were dosage of very long chain fatty acids and brain magnetic resonance. Conclusions: All phenotypes of X-linked adrenoleukodystrophy, except for myelopathy in women, were presented in the studied population, which mainly consisted of children and adolescents. Prevalent signs and symptoms registered in the literature were observed. Most of the patients with cerebral demyelinating inflammatory adrenoleukodystrophy were not diagnosed in time for hematopoietic stem cell transplantation.
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Morgan, H. G., and A. E. Hayward. "Clinical Assessment of Anorexia Nervosa." British Journal of Psychiatry 152, no. 3 (March 1988): 367–71. http://dx.doi.org/10.1192/bjp.152.3.367.
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The Morgan-Russell outcome assessment schedule is described and statistically analysed with reference to two independent series of patients suffering from anorexia nervosa. The value of check lists and simple scaling of data is emphasised as one way of improving the standards of routine case-note documentation in clinical psychiatric practice.
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Dunn, Robert J. H., and Colin P. Morice. "On the effect of reference periods on trends in percentile-based extreme temperature indices." Environmental Research Letters 17, no. 3 (February 25, 2022): 034026. http://dx.doi.org/10.1088/1748-9326/ac52c8.
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Abstract A number of studies have noted that the use of distinct reference periods when comparing indices measuring the frequency of days exceeding a particular temperature percentile threshold leads to apparently different behaviour. We show that these differences arise because of the interplay between the increasing temperatures and the choice of reference period. The time series of the indicators calculated using the different reference periods are offset, as expected, but also diverge. Linear trends calculated over the same period from the same underlying data but where different reference periods have been used are substantially different if a change in climatological conditions has occurred between the two reference periods. We show this not only occurs in our simple empirical approach, but also for the averages of gridded observational and reanalysis datasets and also at a station level. This has implications for data set comparisons using trends in temperature percentile indices that are based on different reference periods. It also has implications for updates to standard reference periods used to monitor the climate.
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Galesloot, Tessel E., Sita H. Vermeulen, Anneke J. Geurts-Moespot, Siem M. Klaver, Joyce J. Kroot, Dorlene van Tienoven, Jack F. M. Wetzels, et al. "Serum hepcidin: reference ranges and biochemical correlates in the general population." Blood 117, no. 25 (June 23, 2011): e218-e225. http://dx.doi.org/10.1182/blood-2011-02-337907.
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AbstractTo date, concentrations of the promising biomarker hepcidin have only been assessed in serum of relatively small series of healthy volunteers and patients. We assessed age- and sex-stratified reference ranges of serum hepcidin concentration in a selected reference set and performed regression analyses to study associations between hepcidin and (biochemical) variables in a large, well-phenotyped sample of the general population (n = 2998). All participants filled out a questionnaire on lifestyle, health status, and medical history. Serum measurements of iron parameters, liver enzyme alanine aminotransferase, creatinine and C-reactive protein were available. Serum hepcidin concentrations were lower for premenopausal than for postmenopausal women (median, 4.1nM vs 8.5nM, respectively). Hepcidin concentrations in men were constant over age (median, 7.8nM). Serum hepcidin was strongly associated with serum ferritin in men and women: β-coefficient of log-transformed variables (95% confidence interval): 0.78 (0.74-0.82) and 0.83 (0.78-0.88), respectively. Additional significant, though less strong, associations were observed for C-reactive protein and total iron binding capacity in men and for total iron binding capacity, alanine aminotransferase, and glomerular filtration rate in women. Our study provides age- and sex-specific reference ranges of serum hepcidin concentration and indicates ferritin as the primary correlate of serum hepcidin concentration.
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Magrone, Thea, Matteo A. Russo, and Emilio Jirillo. "Dietary Approaches to Attain Fish Health with Special Reference to their Immune System." Current Pharmaceutical Design 24, no. 41 (March 20, 2019): 4921–31. http://dx.doi.org/10.2174/1381612825666190104121544.
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Fish despite their low collocation in the vertebrate phylum possess a complete immune system. In teleost fish both innate and adaptive immune responses have been described with melanomacrophage centers (MMCs) equivalent to mammalian germinal centers. Primary lymphoid organs are represented by the thymus and kidney, while spleen and mucosa-associated lymphoid tissues act as secondary lymphoid organs. Functions of either innate immune cells (e.g., macrophages and dendritic cells) or adaptive immune cells (T and B lymphocytes) will be described in detail, even including their products, such as cytokines and antibodies. In spite of a robust immune arsenal, fish are very much exposed to infectious agents (marine bacteria, parasites, fungi, and viruses) and, consequentially, mortality is very much enhanced especially in farmed fish. In fact, in aquaculture stressful events (overcrowding), microbial infections very frequently lead to a high rate of mortality. With the aim to reduce mortality of farmed fish through the reinforcement of their immune status the current trend is to administer natural products together with the conventional feed. Then, in the second part of the present review emphasis will be placed on a series of products, such as prebiotics, probiotics and synbiotics, β-glucans, vitamins, fatty acids and polyphenols all used to feed farmed fish. With special reference to polyphenols, results of our group using red grape extracts to feed farmed European sea bass will be illustrated. In particular, determination of cytokine production at intestinal and splenic levels, areas of MMCs and development of hepatopancreas will represent the main biomarkers considered. All together, our own data and those of current literature suggests that natural product administration to farmed fish for their beneficial effects may, in part, solve the problem of fish mortality in aquaculture, enhancing their immune responses.
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Greenstreet, Simon P. R., and Stuart I. Rogers. "Indicators of the health of the North Sea fish community: identifying reference levels for an ecosystem approach to management." ICES Journal of Marine Science 63, no. 4 (January 1, 2006): 573–93. http://dx.doi.org/10.1016/j.icesjms.2005.12.009.
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Abstract The shift in emphasis away from the single-species focus of traditional fisheries management towards an ecosystem approach to management requires application of indicators of ecosystem state. Further, an ecosystem approach to management requires the identification of ecological reference points against which management objectives might be set. In applying indicators, identifying reference points, and setting objectives, an obvious requirement is that the indicators respond primarily to the anthropogenic activity being managed and are sufficiently sensitive that impacts of the activity and the responses to management action are clearly demonstrable. Here we apply a suite of 12 indicators to Scottish August groundfish survey data collected in the northern North Sea over the period 1925–1997. These include indicators of size structure, life-history character composition, species diversity, and trophic structure within the community. Our choice of analytical design has two purposes; first to show that fishing has unequivocally affected these various aspects of the structure of the groundfish community, and second to illustrate an approach by which long time-series data sets might be used to identify possible management reference points. The results are discussed in the context of selecting ecological indicators in support of an ecosystem approach to management and determining appropriate reference points for objective-setting.
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Nie, Shuhui, Lichen Yang, Jie Feng, Jiaxi Lu, Huidi Zhang, Weidong Li, Yichun Hu, and Xiaoguang Yang. "Reference Range of Vitamin K Evaluating Indicators in Chinese Childbearing Women." Nutrients 15, no. 8 (April 19, 2023): 1977. http://dx.doi.org/10.3390/nu15081977.
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Background: Vitamin K is an essential fat-soluble vitamin for the human body and its functions, such as promoting blood coagulation, bone health and preventing atherosclerosis, have attracted increasing attention. However, there is no recognized indicator and corresponding reference range for evaluating vitamin K status of different populations at present. The aim of this study is to establish a reference range for vitamin K evaluating indicators in healthy women of childbearing age in China. Methods: The population sample in this study was from the Chinese Adult Chronic Disease and Nutrition Surveillance (CACDNS) 2015–2017. A total of 631 healthy women of childbearing age (18–49 years) were included using a series of strict inclusion and exclusion criteria. The concentrations of VK1, MK-4 and MK-7 in serum were detected by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The other commonly-reported indicators evaluating vitamin K nutritional status, including undercarboxylated osteocalcin (ucOC), osteocalcin (OC), matrix Gla protein (MGP), desphosphorylated undercaboxylated MGP (dp-ucMGP) and protein induced by vitamin K absence II (PIVKA-II), were measured by enzyme-linked immunosorbent assay (ELISA). The reference range was obtained by calculating the 2.5% to 97.5% interval of the vitamin K evaluating indicators in the reference population. Results: The reference ranges of VK1, MK-4 and MK-7 in serum were 0.21–3.07 ng/mL, 0.02–0.24 ng/mL and 0.12–3.54 ng/mL, respectively. The reference ranges of ucOC, %ucOC, dp-ucMGP and PIVKA-II were 1.09–2.51 ng/mL, 5.80–22.78%, 2.69–5.88 ng/mL and 3.98–8.40 ng/mL, respectively. The cut-off values that can be used to evaluate subclinical vitamin K deficiency were as follows: VK1 < 0.21 ng/mL, MK-7 < 0.12 ng/mL, ucOC > 2.51 ng/mL, %ucOC > 22.78%, dp-ucMGP > 5.88 ng/mL and PIVKA-II > 8.40 ng/mL. Conclusion: The reference range of VK1, MK-4, MK-7 and vitamin K-related indicators for healthy women of childbearing age established in this study could be used to assess the nutritional and health status of this population.
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Zhang, Huidi, Yang Cao, Pengkun Song, Qingqing Man, Deqian Mao, Yichun Hu, and Lichen Yang. "Suggested Reference Ranges of Blood Mg and Ca Level in Childbearing Women of China: Analysis of China Adult Chronic Disease and Nutrition Surveillance (2015)." Nutrients 13, no. 9 (September 20, 2021): 3287. http://dx.doi.org/10.3390/nu13093287.
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Background: Magnesium and calcium play a variety of biological roles in body functions. Reference values of these elements have not yet been systematically determined in China, especially in childbearing women. We proposed to establish the reference range of Mg, Ca, and Ca/Mg ratio in plasma and whole blood for 18–44 years healthy childbearing women in China. Method: A total of 1921 women of childbearing age (18–44 years) were randomly selected from the 2015 China National Nutrition and Health Survey by taking into account the regional types and monitoring points. Among them, 182 healthy women were screened out with a series strict inclusion criteria to study the reference ranges of elements. Fundamental indicators (weight, height, waist, blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein, fast glucose, HbA1c, blood pressure, uric acid) and elements concentrations in plasma and whole blood were collected. The 2.5th to 97.5th was used to represent the reference range of Mg, Ca, and Ca/Mg ratio. Results: The reference range of Mg, Ca, and Ca/Mg ratio in plasma were 0.75–1.13 mmol/L, 2.27–3.43 mmol/L, and 2.41–3.44, respectively. Additionally, the reference range of Mg, Ca, and Ca/Mg ratio in whole blood were 1.28–1.83 mmol/L, 1.39–2.26 mmol/L, and 0.90–1.66, respectively. According to the established reference range, the prevalence of magnesium deficiency was 4.79% in 1921 childbearing women, 21.05% in type 2 diabetes, and 5.63% in prediabetes. Conclusion: The reference values of Mg, Ca and Ca/Mg proportion in plasma and entire blood of healthy childbearing women can be utilized as a pointer to assess the status of component lack and over-burden. The lower limit of plasma Mg is in good agreement with the recommended criteria for the determination of hypomagnesemia.
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Minca, Eugen C., Bryce P. Portier, Zhen Wang, Christopher Lanigan, G. Thomas Budd, and Raymond R. Tubbs. "Use of HER2 score correction for putative chromosome 17 (Chr-17) aneusomy to increase eligibility for anti-HER2 therapy." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 620. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.620.
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620 Background: HER2 amplification or overexpression status directs therapy choice in breast carcinoma. HER2/Chr-17 ratio is commonly assessed by fluorescence in-situ hybridization (FISH) using a CEP17 centromeric reference probe and ASCO/CAP scoring criteria. However, α-centromeric reference probes may underestimate true HER2 status in cases with para-centromeric amplification. Here we present comprehensive algorithmic testing of an alternative Chr-17 reference locus for resolution of putative CEP17-aneusomic cases in a consecutive series, within a single health system. Methods: 150 of 1256 consecutive breast carcinoma cases accessioned in 2011 within the Cleveland Clinic Health System displayed a mean CEP17 copy number greater than 3.0 by FISH (aneusomy). The patients were reflex-HER2 tested by FISH with a reference probe for the D17S122 locus (17p12) and a corrected HER2/Chr-17 ratio was calculated. Cases with equivocal HER2/D17S122 ratio (1.8-2.2) were further reflex tested for HER2 overexpression by immunohistochemistry (IHC). Results: Of 117 initially non-amplified cases by HER2/CEP17, 20 (17%) were revised to amplified and 18 (15.3%) to equivocal by HER2/D17S122. Of 3 initially equivocal cases, 1 was revised to amplified and 1 remained equivocal. Of the 19 equivocal cases by HER2/D17S122, 3 were revised to positive by IHC. Overall, for CEP17 aneusomic cases tested using this algorithmic approach, 24 of 120 (20%) patients with initial non-amplified or equivocal HER2 status became eligible for anti-HER2-based therapy, which was also considered in 10 equivocal cases with a HER2/D17S122 ratio of 2.0 - 2.2. A significantly lower proportion of initially amplified cases was revised as non-amplified by HER2/D17S122 (1 of 30, 3.3%, p<0.05). Conclusions: Our data, collected within a single health system for a consecutive case series, underscores the clinical limitations of commonly used FISH probes for HER2 testing and demonstrates that algorithmic use of a non-centromeric Chr-17 reference probe alters HER2 status and increases eligibility for anti-HER2 based therapy in a significant proportion of patients.
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Shwe, A. M., E. D. Heckerman, M. Henrion, J. E. Horvitz, P. H. Lehmann, F. G. Cooper, and B. Middleton. "Probabilistic Diagnosis Using a Reformulation of the INTERNIST-1/QMR Knowledge Base." Methods of Information in Medicine 30, no. 04 (1991): 256–67. http://dx.doi.org/10.1055/s-0038-1634847.
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AbstractWe have developed a probabilistic reformulation of the Quick Medical Reference (QMR) system. In Part I of this two-part series, we described a two-level, multiply connected belief-network representation of the QMR knowledge base and a simulation algorithm to perform probabilistic inference on the reformulated knowledge base. In Part II of this series, we report on an evaluation of the probabilistic QMR, in which we compare the performance of QMR to that of our probabilistic system on cases abstracted from continuing medical education materials from Scientific American Medicine. In addition, we analyze empirically several components of the probabilistic model and simulation algorithm.
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Lei, Zhen, Liang Zhu, Youliang Fang, Xiaolei Li, and Beizhan Liu. "Anomaly detection of bridge health monitoring data based on KNN algorithm." Journal of Intelligent & Fuzzy Systems 39, no. 4 (October 21, 2020): 5243–52. http://dx.doi.org/10.3233/jifs-189009.
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Pattern recognition technology is applied to bridge health monitoring to solve abnormalities in bridge health monitoring data. Testing is of great significance. For abnormal data detection, this paper proposes a single variable pattern anomaly detection method based on KNN distance and a multivariate time series anomaly detection method based on the covariance matrix and singular value decomposition. This method first performs compression and segmentation on the original data sequence based on important points to obtain multiple time subsequences, then calculates the pattern distance between each time subsequence according to the similarity measure of the time series, and finally selects the abnormal mode according to the KNN method. In this paper, the reliability of the method is verified through experiments. The experimental results in this paper show that the 5/7/9 / 11-nearest neighbors point to a specific number of nodes. Combined with the original time series diagram corresponding to the time zone view, in this paragraph in the time, the value of the temperature sensor No. 6 stays at 32.5 degrees Celsius for up to one month. The detection algorithm controls the number of MTS subsequences through sliding windows and sliding intervals. The execution time is not large, and the value of K is different. Although the calculated results are different, most of the most obvious abnormal sequences can be detected. The results of this paper provide a certain reference value for the study of abnormal detection of bridge health monitoring data.
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Yang, Jingxin, Yang Cao, Xiaoyun Shan, Huidi Zhang, Jie Feng, Jiaxi Lu, and Lichen Yang. "The Magnesium Status and Suggested Reference Ranges of Plasma Magnesium, Calcium, and Calcium/Magnesium Ratio in Chinese Adults over 45 Years Old." Nutrients 15, no. 4 (February 9, 2023): 886. http://dx.doi.org/10.3390/nu15040886.
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Magnesium (Mg) is an essential nutrient that participates in various enzymatic reactions and regulates important biological functions. The distribution and reference ranges in China have not been reported in populations more than 45 years old. This study aimed to assess the magnesium status and determine the reference values of plasma Mg, Ca, and Ca/Mg ratios for China’s population more than 45 years old. A total of 2101 people were randomly selected from the China Nutrition and Health surveillance (CNHS) (2015–2017), considering the regional types and monitoring points. Then, 337 healthy individuals were further selected by a series of strict inclusion criteria to explore the reference range. The plasma magnesium and calcium were tested by inductively coupled plasma mass spectrometry (ICP-MS). The suggested reference values for plasma Mg, Ca, and Ca/Mg ratios were 0.75–1.14 mmol/L, 2.17–3.64 mmol/L, and 2.36–3.66, respectively. Taking 0.75 mmol/L as the lower cut-off limit, the prevalence of Mg deficiency was 6.66%, and the average level of plasma magnesium was 0.88 mmol/L for populations older than 45 years in China. In conclusion, this study provides the magnesium status and reference ranges for plasma Mg, Ca, and Ca/Mg ratio for Chinese people over 45 years old. The results of the recommended reference ranges in this study were very similar to our published results in women of reproductive age. Thus, the reference range of plasma magnesium in different populations in China was further improved.
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Gash, Sarah. "Women’s Health Concerns Sourcebook200029Edited by Heather E. Aldred. Women’s Health Concerns Sourcebook . Detroit, MI: Omnigraphics 1997. 567 pp, ISBN: 0 7808 0219 5 Health Reference Series volume 27." Reference Reviews 14, no. 1 (January 2000): 31–32. http://dx.doi.org/10.1108/rr.2000.14.1.31.29.
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Devi, Salma, Zara Yunizar, and Sujacka Retno. "Comparison of Chen's Fuzzy Time Series and Triple Exponential Smoothing in Forecasting Medicine Stocks at the Blang Cut Kuala Community Health Center." Journal of Advanced Computer Knowledge and Algorithms 1, no. 3 (July 1, 2024): 64. http://dx.doi.org/10.29103/jacka.v1i3.16870.
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Forecasting is estimating future conditions by examining conditions in the past. In social life, everything is uncertain and difficult to predict precisely, so forecasting is needed. Efforts are always made to make forecasts in order to minimize the influence of this uncertainty on a problem. In other words, forecasting aims to obtain forecasts that can minimize forecast errors, which are usually measured by the mean absolute percentage error. This method is usually used for time series-based forecasting and uses data or information from the past as a reference when predicting current data. This research will compare the application of the Fuzzy Time Series Chen method and the Triple Exponential Smoothing method in forecasting drug stock determination at the Kuala Community Health Center, Blang Mangat District, Lhokseumawe City Regency, Aceh. The research results showed that the Triple Exponential Smoothing method was better in forecasting drug stock inventories compared to Chen's Fuzzy Time Series method. Chen's Fuzzy Time Series method produces a MAPE value of 17.67%, which means it has an accuracy of 82.33%, while the Triple Exponential Smoothing method produces a MAPE value of 9.842%, which means it has an accuracy of 90.158%
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Damiance, Patrícia Ribeiro Mattar, and Vanessa Clivelaro Bertassi Panes. "SHARING KNOWLEDGE AND TEACHING EXPERIENCES IN A REFERENCE CENTER FOR LEPROSY." Hansenologia Internationalis: hanseníase e outras doenças infecciosas 41, no. 1/2 (November 30, 2016): 105–13. http://dx.doi.org/10.47878/hi.2016.v41.34993.
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This study aims to report an experience of a curricular internship in nursing based on the investigative methodology in a Reference Center for Leprosy. It is an experience report structured in the description of a series of activities, components of a didactic sequence, whose contents permeate the construction of the care for adults and the elderly with Leprosy and /or other skin and appendages alterations. The educational goals and the teaching techniques used supported the discussion on the construction of knowledge from the perspective of the critical pedagogy and public policies that guide the academic formation in the health area. Among the lessons learned, we highlight the role of intervention and teaching mediation in the learning process, as well as the relevance of the reflective practice as essential and leveraging of transformation in the educational process.
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Botrugno, Carlo. "Cybersecurity, privacy, and health data protection in the digital strategy of the European Union." Revista de Estudos Constitucionais, Hermenêutica e Teoria do Direito 14, no. 3 (August 14, 2023): 300–312. http://dx.doi.org/10.4013/rechtd.2022.143.01.
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Contemporary societies increasingly rely on the opportunities created by technologies that make possible the production, collection, processing, and reuse of huge datasets to obtain inferences that can be used in the most disparate fields. Among these, healthcare stands out in importance since in medical practice a considerable series of personal information is exchanged and shared. The protection needs of the individual sphere in the healthcare sector acquire a specific scope with reference to the use of information and communication technologies, which allow patients and healthcare professionals to communicate, or the latter among them, in view of the achievement of a series of goals that pertain to the diagnosis, prevention, monitoring, rehabilitation and treatment of an increasingly large number of diseases. In such a context, this works aims at proving a synthetic overview on the whole architecture adopted by the European Union in the field of cybersecurity, privacy, and health data protection, which appears fundamental for guaranteeing the fundamental rights of European citizens but also to deal with the challenges posed by the digital transition of contemporary societies.
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Kipnis, Daniel G. "Book Review: A Practical Guide for Informationists: Supporting Research and Clinical Practice." Reference & User Services Quarterly 58, no. 2 (January 18, 2019): 119. http://dx.doi.org/10.5860/rusq.58.2.6932.
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The Chandos’ book series is designed to help the overworked librarian with practical advice using extensive case studies. The book begins with defining “informationist” and outlining the transformation from a traditional reference librarian to an informationist. The theme of the book deals with filling “information” gaps and each chapter focuses on different types of services that can help fill information gaps at a variety of health institutions.
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Li, Jun, Hongfei Gao, Yunjing Li, Shanshan Zhai, Fang Xiao, Gang Wu, and Yuhua Wu. "The Development of a Series of Genomic DNA Reference Materials with Specific Copy Number Ratios for The Detection of Genetically Modified Maize DBN9936." Foods 13, no. 5 (February 28, 2024): 747. http://dx.doi.org/10.3390/foods13050747.
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The genetically modified (GM) maize DBN9936 with a biosafety certificate will soon undergo commercial application. To monitor the safety of DBN9936 maize, three genomic DNA (gDNA) reference materials (RMs) (DBN9936a, DBN9936b, and DBN9936c) were prepared with nominal copy number ratios of 100%, 3%, and 1% for the DBN9936 event, respectively. DBN9936a was prepared from the leaf tissue gDNA of DBN9936 homozygotes, while DBN9936b and DBN9936c were prepared by the quantitative mixing of gDNA from the leaf tissues of DBN9936 homozygotes and non-GM counterparts. Validated DBN9936/zSSIIb duplex droplet digital PCR was demonstrated to be an accurate reference method for conducting homogeneity study, stability study, and collaborative characterization. The minimum intake for one measurement was determined to be 2 μL, and the gDNA RMs were stable during transport at 37 °C for 14 days and storage at −20 °C for 18 months. Each gDNA RM was certified for three property values: DBN9936 event copy number concentration, zSSIIb reference gene copy number concentration, and DBN9936/zSSIIb copy number ratio. The measurement uncertainty of the certified values took the uncertainty components related to possible inhomogeneity, instability, and characterization into account. This batch of gDNA RMs can be used for calibration and quality control when quantifying DBN9936 events.
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Su, Sih-Ping, Chia-Ying Hsu, Nai-Chieh Wei, Hao-Tien Liu, and Pei-Tsang Wu. "Hierarchical analysis of barrier-free ramp scoring criteria." Journal of Statistics and Management Systems 26, no. 8 (2023): 1905–14. http://dx.doi.org/10.47974/jsms-1087.
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When building an accessible facility, there will be a series of projects to be evaluated. Therefore, through the World Health Organization’s “ Global Aging-friendly Cities: A Guide “ released by the World Health Organization in 2007, this study is based on eight aspects and serves as a reference for cities to promote age-friendly cities. In addition, the importance weights are obtained through interviews with experts and scholars. At the same time, when setting up accessible ramps, special attention should be paid to protective measures, guardrails, and handrails.
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Faradiela, Princessa Aulia, Arief Wibowo, and Yeni Rahmah Husniyawati. "FORECASTING THE NUMBER OF VERTICAL REFERRALS FOR BPJS PARTICIPANTS AT HEALTH SERVICE CENTER IN UNIVERSITAS AIRLANGGA USING ARIMA MODEL." Jurnal Biometrika dan Kependudukan 11, no. 1 (July 6, 2022): 62–71. http://dx.doi.org/10.20473/jbk.v11i1.2022.62-71.
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Autoregressive Integrated Moving Average (ARIMA) is a time series forecasting method to estimate future events using past data. It can perform short-term forecasting on data with all types of data patterns, both seasonal and non-seasonal data. This study aims to report the best ARIMA for vertical referral cases in BPJS PLK Universitas Airlangga participants. This method used to analyze the number of vertical references for BPJS participants. The research method used is non-intrusive using secondary data and the sample used was the entire population of vertical point reference data for BPJS PLK UNAIR in 2020. The purposive sampling used until 266 data are found. The results of the analysis show that the ARIMA model used to estimate the number of vertical referrals participants is AR [6] or also known as ARIMA [6,0,0]. As for PLK Campus B UNAIR is ARIMA [0,1,1]. In this model, all diagnostic tests have met the assumption requirements. The results of forecasting the number of vertical referrals in PLK Campus C shows the number of vertical referrals will tend to have a constant or horizontal trend with a smaller reference value than the data in 2020. Meanwhile, the number of vertical referrals of PLK Campus B UNAIR has decreased in number compare to 2020. This forecasting has a MAPE value below 10% so the forecasting model has a very good performance in forecasting examples of vertical referrals for BPJS participants in the future. Then the results are useful for making policies to deal with future cases.
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Swetnam, Tyson L., Stephen R. Yool, Samapriya Roy, and Donald A. Falk. "On the Use of Standardized Multi-Temporal Indices for Monitoring Disturbance and Ecosystem Moisture Stress across Multiple Earth Observation Systems in the Google Earth Engine." Remote Sensing 13, no. 8 (April 8, 2021): 1448. http://dx.doi.org/10.3390/rs13081448.
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In this work we explore three methods for quantifying ecosystem vegetation responses spatially and temporally using Google’s Earth Engine, implementing an Ecosystem Moisture Stress Index (EMSI) to monitor vegetation health in agricultural, pastoral, and natural landscapes across the entire era of spaceborne remote sensing. EMSI is the multitemporal standard (z) score of the Normalized Difference Vegetation Index (NDVI) given as I, for a pixel (x,y) at the observational period t. The EMSI is calculated as: zxyt = (Ixyt − µxyT)/σxyT, where the index value of the observational date (Ixyt) is subtracted from the mean (µxyT) of the same date or range of days in a reference time series of length T (in years), divided by the standard deviation (σxyT), during the same day or range of dates in the reference time series. EMSI exhibits high significance (z > |2.0 ± 1.98σ|) across all geographic locations and time periods examined. Our results provide an expanded basis for detection and monitoring: (i) ecosystem phenology and health; (ii) wildfire potential or burn severity; (iii) herbivory; (iv) changes in ecosystem resilience; and (v) change and intensity of land use practices. We provide the code and analysis tools as a research object, part of the findable, accessible, interoperable, reusable (FAIR) data principles.
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Valina, Svetlana L., Olga Yu Ustinova, Maksim A. Savinkov, Larisa V. Osheeva, Olga A. Kobyakova, and Daria A. Eisfeld. "A role of technogenic chemical risk factors in the development of cognitive dysfunctions in children in a zone of exposure to the non-ferrous metallurgic enterprises." Hygiene and sanitation 101, no. 11 (November 30, 2022): 1354–61. http://dx.doi.org/10.47470/0016-9900-2022-101-11-1354-1361.
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Introduction. Cognitive disorders in children reduce their social abilities and abilities to learn; therefore, correct diagnostics and prevention of such disorders is a pressing medical and social issue. Materials and methods. The test group was made of two hundred sixty eight 4-7 years children lived and attended preschool children facilities in a zone exposed to emissions from a non-ferrous metallurgic enterprise. The reference group included 97 unexposed children of the same age. We analyzed ambient air quality on both territories. Cognitive processes were estimated by using a series of tests. Laboratory tests were aimed at estimating peroxidation-antioxidant balance, levels of neuromediators and neurotrophic factors in blood serum. Results. The children from the test group had chemicals in their blood and urine in concentrations being both higher than the reference values and those detected in the reference group. Thus, manganese contents in their blood were by 1.3 times higher and aluminum contents in urine were by 1.7-2.2 times higher (p<0.001). Tests applied to estimate development of perception, logical thinking, attention and sensorimotor coordination, revealed that the exposed children were by 1.2-2.0 times less efficient in doing them than their counterparts from the reference group (p = 0.001-0.034). We established a relationship between likelihood of poorer perception and thinking and contents of manganese and aluminum in biological media (R2 = 0.28-0.33). The children in the test group had by 1.2-1.5 times higher contents of malonic dialdehyde (25% contributed by aluminum and 31% contributed by manganese) and lipid peroxides (71% contributed by aluminum) in blood plasma. Antioxidant activity of blood plasma was by 1.2 times lower in the test group, nurotropin-3 contents were higher (13% contributed by manganese) and neuron-specific enolase in blood serum tended to decrease (58% contributed by aluminum). Limitations. Age-related limitations concerning the applied series of tests. Conclusion. Poorer perception and logical thinking, intensified lipid peroxidation and impaired balance of neurotrophic factors are target indicators necessary when developing relevant medical and preventive activities for children in a zone exposed to a non-ferrous metallurgic enterprise.
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Lassen, Anne D., Lene M. Christensen, and Ellen Trolle. "Development of a Danish Adapted Healthy Plant-Based Diet Based on the EAT-Lancet Reference Diet." Nutrients 12, no. 3 (March 11, 2020): 738. http://dx.doi.org/10.3390/nu12030738.
Full textAbstract:
Plant-based diets have been linked to both health benefits and a lower climate impact. However, plant-based diets may represent both healthy and unhealthy dietary practices. The present study aimed to develop a nationally adapted healthy plant-based diet based on the global EAT-Lancet reference diet. Development took place in a series of steps. First, the original EAT-Lancet reference diet was evaluated based on food availability, i.e., using Danish food data (Model 1). Then, the model was further modified to reflect national food based dietary guidelines (FBDG) and characteristics of current consumption pattern, e.g., by including processed food, discretionary foods and beverages in the diet (Model 2). The contents of macronutrients, vitamins and minerals, except for vitamin D and iodine, were found to be sufficient for Model 2, according to the recommended nutrient density to be used for planning diets for groups of individuals aged 6–65 years. In addition, the study gave an insight into the nutrients and foods to be aware of in planning a predominantly plant-based diet, thereby providing directions for future revisions of sustainable FBDGs. These include a stronger emphasis on the intake of legumes, nuts and seeds, fruit and vegetables including dark green vegetables, whole-grain products and vegetable oils as well as lowering meat intake.
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Telesca, Vito, Gianfranco Castronuovo, Gianfranco Favia, Cristina Marranchelli, Vito Alberto Pizzulli, and Maria Ragosta. "Effects of Meteo-Climatic Factors on Hospital Admissions for Cardiovascular Diseases in the City of Bari, Southern Italy." Healthcare 11, no. 5 (February 26, 2023): 690. http://dx.doi.org/10.3390/healthcare11050690.
Full textAbstract:
The objective of this study was to determine the relationship between weather conditions and hospital admissions for cardiovascular diseases (CVD). The analysed data of CVD hospital admissions were part of the database of the Policlinico Giovanni XXIII of Bari (southern Italy) within a reference period of 4 years (2013–2016). CVD hospital admissions have been aggregated with daily meteorological recordings for the reference time interval. The decomposition of the time series allowed us to filter trend components; consequently, the non-linear exposure–response relationship between hospitalizations and meteo-climatic parameters was modelled with the application of a Distributed Lag Non-linear model (DLNM) without smoothing functions. The relevance of each meteorological variable in the simulation process was determined by means of machine learning feature importance technique. The study employed a Random Forest algorithm to identify the most representative features and their respective importance in predicting the phenomenon. As a result of the process, the mean temperature, maximum temperature, apparent temperature, and relative humidity have been determined to be the most suitable meteorological variables as the best variables for the process simulation. The study examined daily admissions to emergency rooms for cardiovascular diseases. Using a predictive analysis of the time series, an increase in the relative risk associated with colder temperatures was found between 8.3 °C and 10.3 °C. This increase occurred instantly and significantly 0–1 days after the event. The increase in hospitalizations for CVD has been shown to be correlated to high temperatures above 28.6 °C for lag day 5.