Relevant bibliographies by topics / HEALING AGENT

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'HEALING AGENT'

Author: Grafiati
Published: 11 September 2023

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Journal articles on the topic "HEALING AGENT"

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Shields, Yasmina, Vanessa Cappellesso, Tim Van Mullem, Nele De Belie, and Kim Van Tittelboom. "A comparison of potential healing agents for vascular-based self-healing concrete." MATEC Web of Conferences 378 (2023): 02026. http://dx.doi.org/10.1051/matecconf/202337802026.

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Vascular self-healing concrete is an innovative technology that can potentially improve the durability and longevity of concrete structures. However, limited research is available concerning this type of self-healing compared to intrinsic or capsule-based healing. As the rheology and curing properties of a healing agent can dictate the optimal design configuration of a vascular network, a series of testing procedures for evaluating healing agents is further explored. In this study, the suitability of various commercially available healing agents is considered using a vascular network system in mechanical loading and water absorption test set-ups. In this particular configuration, high sealing efficiencies were obtained for most of the healing agents used, and the polyurethanes and epoxy resin that were studied showed high load regain values. This work provides a testing methodology to select a healing agent in terms of its mechanical load regain, sealing efficiency, rheology, and curing properties, and can be used to determine a suitable healing agent for vascular healing applications.
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Ebrahimnezhad-Khaljiri, Hossein, Reza Eslami-Farsani, and Sadegh Mirzamohammadi. "The effect of capsulated nanosilica-epoxy healing agents on the self-healing ability of glass fibers-epoxy composites under mechanical loading." Journal of Industrial Textiles 52 (August 2022): 152808372211198. http://dx.doi.org/10.1177/15280837221119833.

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In this study, the effect of using an epoxy healing agent containing silica nanoparticles instead of the neat epoxy healing agent on the self-healing ability of glass fibers/epoxy composites under the flexural, tensile and shear loadings was assessed. For doing this, in the first step, the silica nanoparticles (0, 1, 2 and, 3 wt.%) were dispersed into the ethyl acetate/epoxy healing agent. Then, these mixtures were encapsulated with the urea-formaldehyde polymer by an in-situ polymerization method. Finally, the glass fibers/epoxy composite containing 14 wt.% microcapsules along with 2 wt.% NiCl2(imidazole)4 catalyst were fabricated. To understand how the mechanical-healing behaviors of these composites under the various mechanical loads, these composites were destructed with a quasi-static penetration test for the creation of delamination damage. The healing process was done by the thermal activation method. The obtained results showed that the highest healing efficiency under the flexural, tensile and shear loads belonged to the composite containing 1 wt.% nanosilica into the healing agent, which were 89.8, 87.8, and 156.8%, respectively. The hackles of microcapsules, reduction in the thickness of microcapsules, formation of nanocomposite healing shell and the agglomeration of silica nanoparticles on the healed area were the influence factors on the healing ability of these composites. This work can give a view for healing the microcracks into composite structures by nanocomposite healing agents, which have the higher healing ability and better performance under mechanical loads than conventional healing agents.
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Song, Dowon, Taeseup Song, Ungyu Paik, Guanlin Lyu, Yeon-Gil Jung, Baig-Gyu Choi, In-Soo Kim, and Jing Zhang. "Crack-Resistance Behavior of an Encapsulated, Healing Agent Embedded Buffer Layer on Self-Healing Thermal Barrier Coatings." Coatings 9, no. 6 (May 31, 2019): 358. http://dx.doi.org/10.3390/coatings9060358.

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In this work, a novel thermal barrier coating (TBC) system is proposed that embeds silicon particles in coating as a crack-healing agent. The healing agent is encapsulated to avoid unintended reactions and premature oxidation. Thermal durability of the developed TBCs is evaluated through cyclic thermal fatigue and jet engine thermal shock tests. Moreover, artificial cracks are introduced into the buffer layer’s cross section using a microhardness indentation method. Then, the indented TBC specimens are subject to heat treatment to investigate their crack-resisting behavior in detail. The TBC specimens with the embedded healing agents exhibit a relatively better thermal fatigue resistance than the conventional TBCs. The encapsulated healing agent protects rapid large crack openings under thermal shock conditions. Different crack-resisting behaviors and mechanisms are proposed depending on the embedding healing agents.
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Pan, Changluan, Ping Tang, Martin Riara, Liantong Mo, Mingliang Li, and Meng Guo. "Effect of Healing Agents on Crack Healing of Asphalt and Asphalt Mortar." Materials 11, no. 8 (August 7, 2018): 1373. http://dx.doi.org/10.3390/ma11081373.

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This study investigated the effect of seven healing agents on crack healing ability of long-term aged asphalt and its mortar. Different healing agents including sunflower oil, aromatic oil, bitumen emulsion, and maltene-based emulsions were used. The crack healing of asphalt made use of two asphalt disk samples and healing was evaluated using direct tensile tests. For asphalt mortar, notched semi-circular samples were used. Test results indicated that the crack healing of asphalt and its mortar depended strongly on the type of healing agent. In general, asphalt healed faster than its mortar. Asphalt healing could be well improved by using oil agents, while asphalt mortar could be well healed with maltene-based emulsions. The crack healing of asphalt mortar developed rapidly followed by a steady state of increase. Initial crack healing using healing agents could be contributed by the diffusion and softening effects, which resulted in low strength recovery. Long term healing could lead to the bonding reconstitution in the cracks, which were decisive for the final strength gain. The promising healing agent should be able to achieve maximum strength recovery to resist cracking as well as a sufficient re-healing ability to deal with crack opening and closing.
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Mendelson, Myer D. "Psychoanalysis: Healing Agent or Catalyst?" Contemporary Psychoanalysis 31, no. 1 (January 1995): 106–12. http://dx.doi.org/10.1080/00107530.1995.10746898.

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Horrigan, Bonnie J. "Meaning as a Healing Agent." EXPLORE 8, no. 6 (November 2012): 323–25. http://dx.doi.org/10.1016/j.explore.2012.08.007.

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De Nardi, Cristina, Diane Gardner, and Anthony Duncan Jefferson. "Development of 3D Printed Networks in Self-Healing Concrete." Materials 13, no. 6 (March 14, 2020): 1328. http://dx.doi.org/10.3390/ma13061328.

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This paper presents a new form of biomimetic cementitious material, which employs 3D-printed tetrahedral mini-vascular networks (MVNs) to store and deliver healing agents to damage sites within cementitious matrices. The MVNs are required to not only protect the healing agent for a sufficient period of time but also survive the mixing process, release the healing agent when the cementitious matrix is damaged, and have minimal impact on the physical and mechanical properties of the host cementitious matrix. A systematic study is described which fulfilled these design requirements and determined the most appropriate form and material for the MVNs. A subsequent series of experiments showed that MVNs filled with sodium silicate, embedded in concrete specimens, are able to respond effectively to damage, behave as a perfusable vascular system and thus act as healing agent reservoirs that are available for multiple damage-healing events. It was also proved that healing agents encapsulated within these MVNs can be transported to cracked zones in concrete elements under capillary driving action, and produce a recovery of strength, stiffness and fracture energy.
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Yin, Tao, Min Zhi Rong, and Ming Qiu Zhang. "Self-Healing Epoxy Composites – Part II: Healing Performance." Advanced Materials Research 716 (July 2013): 387–90. http://dx.doi.org/10.4028/www.scientific.net/amr.716.387.

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Epoxy composites were provided with healing capability by pre-dispersing a novel repair system in the composites matrix cured by 2-ethyl-4-methylimidazole (2E4MIm). The healing agent consisted of ureaformaldehyde microcapsules containing epoxy and latent hardener CuBr2(2-MeIm)4 (the complex of CuBr2 and 2-methylimidazole). Single-edge notched bending (SENB) test were conducted to evaluate fracture toughness of the composites before and after healing. Moreover, healing efficiency was studied as a function of the content of the two-component healing agents. It was found that a healing efficiency of 173% relative to the fracture toughness of virgin composites was obtained in the case of 15 wt% epoxy-loaded microcapsules and 3 wt% CuBr2(2-MeIm)4.
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Napavichayanun, Supamas, Rungnapha Yamdech, Prompong Pienpinijtham, Teerapol Srichana, Siripich Chencharoenwong, Narendra Reddy, and Pornanong Aramwit. "Using polyvinyl alcohol-ionic hydrogels containing a wound healing agent to manage wounds in different environments." Journal of Wound Care 31, Sup8 (August 1, 2022): S12—S21. http://dx.doi.org/10.12968/jowc.2022.31.sup8.s12.

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Objective: To explore the effects of pH on properties of polyvinyl alcohol (PVA)-ionic hydrogels containing wound healing promoters. Method: PVA was combined with a natural wound healing promoter (silk sericin (SS)), and an anionic agent (eosin (ES)) or cationic agent (methylene blue (MB)), and made into hydrogels. Properties of the hydrogels and behaviour at different pHs were investigated. Results: The density and gel fraction of PVA/SS-ES hydrogel and PVA/SS-MB hydrogel were considerably lower compared with hydrogel without SS. The swelling ratio and degradation of the hydrogels increased with increasing SS concentration in all pH solutions. The influence of SS in interrupting long-chain PVA molecules was confirmed based on changes in Fourier-transform infrared spectroscopy (FTIR). The SS released from the gels was found to interact with the ionic agent and influenced the release profile of the ionic agent. Surprisingly, the anionic agent in PVA/SS-ES hydrogel showed 70% release in high pH solution whereas the cationic agent in PVA/SS-MB hydrogel showed 86% release in low pH solution. Moreover, the active agent could accumulate on the skin layer and had a positive effect on a specific wound area. Conclusion: Based on the results obtained in this study, it is suggested to use anionic hydrogels containing wound healing promoter for wounds at high pH and cationic hydrogels containing wound healing promoter for wounds with low pH. Ability to improve wound healing using a natural healing agent combined with ionic agents and controlling the pH of hydrogels will help in developing quick and low-cost treatment for wounds.
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Huang, Feng, and Shuai Zhou. "A Review of Lightweight Self-Healing Concrete." Materials 15, no. 21 (October 28, 2022): 7572. http://dx.doi.org/10.3390/ma15217572.

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Cementitious composites often crack because of their low tensile strength. The ability of self-healing cementitious composite to automatically repair cracks has attracted widespread attention. Lightweight aggregate (LWA) has a low density and a high porosity which can provide storage space for a healing agent. The healing mechanisms and healing compositions of lightweight self-healing concrete (LWSHC) have been summarized in this research. The workability, compressive strength, crack repairing, and durability of LWSHC performance is also illustrated. A LWA with interconnected pores and a high strength should be integrated into LWSHC to increase the crack closure rate and mechanical properties. Expanded perlite is the most suitable LWA carrier for bioremediation. The chemical healing agents are better than the biological healing agents at present since the biological healing agents have more negative effects. A sodium silicate solution is a good choice as a chemical healing agent. Vacuum conditions, high-temperature processing, and the use of coating technologies on LWAs can improve the healing effect of LWSHC. The addition of fibers also enhance the self-healing ability of LWSHC. Further, the use of numerical simulation supports the healing performance of LWSHC. The goal of this research is to investigate the most appropriate component of LWSHC to ensure a high crack closure rate, strength healing ratio, and great durability while being lightweight. It can then be adopted in high-rise and large-span concrete structures to extend the service life.
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Dissertations / Theses on the topic "HEALING AGENT"

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Wang, Xufeng Materials Science &amp Engineering Faculty of Science UNSW. "Application of single-part adhesives as healing agent in self-healing composites." Awarded by:University of New South Wales. Materials Science and Engineering, 2007. http://handle.unsw.edu.au/1959.4/32233.

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The aim of this study was to develop a new single-part healing system for self-healing composites. The self-healing approach to composite repair has been developed in the last two decades and means that a damaged area can be repaired by material already housed within the structure. The background and development of self-healing has been reviewed. The two main self-healing mechanisms are discussed. To date only two part self healing systems have been examined. These require diffusion of the separate constituents to a single location in order to effect cure and restore strength. Single part adhesives do not have this disadvantage and are therefore very attractive. Several candidate single-part adhesive or resin systems were considered and discussed according to the critical requirements of a self-healing system. A series of experiments was undertaken to evaluate the possibility of candidate adhesive systems being effective for self-healing by focusing on the determination of storage stability and bonding efficiency. The results of storage stability testing showed that the stability of cyanoacrylate and polyurethane adhesives was poor. However silane and polystyrene cements showed good storage stability. Very low bonding efficiency was achieved with polystyrene cement but a 22% strength recovery was obtained with the silane 3-[tris(trimethylsiloxy)silyl]-propylamine. Suggestions for further research into single-part healing systems are also given.
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Shaohua, Qi. "Self-Healing Cements with Epoxy and Mercaptan Microcapsules or Polycaprolactone Particles as Healing Agent." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27395.

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Cementitious materials are the most wildly used construction materials in the world, and the development of self-healing cementitious materials are highly beneficial. The aim of the thesis is to use dual-microcapsules or polycaprolactone as self-healing agent, and to study the self-healing properties and fracture mechanics of the self-healing cement. Microcapsule based self-healing cement in this work is fabricated by adding 10, 20 and 30 wt.% of dual-microcapsules to the cement. The dual-microcapsule system contains a bisphenol A diglycidyl ether (DGEBA) epoxy resin in one capsule and pentaerythritol tetrakis (i.e. mercaptan) as hardener in the other capsule. Polycaprolactone (PCL) based self-healing cement is prepared by adding 10, 20 and 30 wt.% of PCL powders to the cement. The study of self-healing efficiency and fracture behaviour of the self-healing cement are carried out using the TDCB (tapered double-cantilever beam) fracture tests. For the microcapsules based self-healing system, microcapsules can be classified by three diameters. The diameters of epoxy microcapsules are 210 μm and 71 μm; the diameters of mercaptan microcapsules are 181 μm and 77 μm. The epoxy TDCB with inserted cement block was adopted in fracture characterization of the virgin cements without and with the healing agent as well as that after healing. The cement block is square or round in shape; the specimens with square shape cement showed inconsistent cracking, and most cracking started from edges rather than the pre-crack. The specimens with round shape cement showed consistent cracking along the pre-crack. 10, 20 and 30 wt.% of large microcapsules were added in the cement. The average healing efficiency of cement specimens is 4.6%, 48.1%, and 25.4%, respectively, for 10%, 20%, and 30% of large microcapsules, increasing with the content of healing agent. For the PCL based self-healing system, the average diameter of PCL powder is 367 μm, and the melting point is 63°C defined by DSC. Rheology of PCL powders shows shear thinning behavior due to a decrease of viscosity under shear rate. The specimens healed at 110°C show better healing efficiency than those healed at 90°C; all of them reach 100% of healing efficiency except the specimens with 10% of PCL healed at 90°C. The maximum healing efficiency reaches 244% for the specimens embedded with 30% of PCL and healed at 110°C. In conclusion, the healing efficiency increases with the content of epoxy microcapsules or PCL particles, because more coverage of the epoxy or PCL on the cracked surfaces. PCL-based cement at a high healing temperature shows better healing efficiency owing to the lower viscosity and better flow of PCL. PCL-based self-healing system shows better healing efficiency than epoxy microcapsules because of some microcapsules ruptured during the mixing process with the cement, losing its function.
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Bou, ghosn Steve Martin. "Simulating Multi-Agent Decision Making for a Self Healing Smart Grid." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27200.

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Dynamic real-time power systems like the national power grid operate in continuously changing environments such as adverse weather conditions, power line malfunctions, device failures, etc. These disruptions can lead to different fault conditions in the power system, ranging from a local outage to a cascading failure of global proportions. It is vital to be able to guarantee that all consumers with critical loads won?t be seriously affected when these outages occur, and to also be able to detect potential faults early on, to prevent them from spreading and creating a generalized failure. In order to achieve this, the power grid must be able to perform intelligent behavior to adapt to ever changing conditions and also to self-heal itself in the event that a fault condition occurs. The Smart Grid must continuously monitor its own status and if an abnormal state is detected, it must automatically perform corrective actions to restore the grid to a healthy state. Due to the large scale and complexity of the Smart Grid, anticipating all possible scenarios that lead to performance lapses is difficult [2]. There is a high degree of uncertainty in accurately estimating the impact of disruptions on the reliability, availability and efficiency of the power delivery system. The use of simulation models can promote trust in Smart Grid solutions in safe and cost effective ways. In this work, we first present an innovative framework that can be used as a design basis when implementing agent based simulations of the smart grid. The framework is based on two primary concepts. First, the electrical grid system is separated into semi-autonomous units or micro-grids, each with their own set of hierarchically organized agents. Second, models for automating decision-making in the grid during crisis situations are independently supported, allowing simulations that can test how agents respond to the various scenarios that can occur in the smart grid using different decision models. Advantages of this framework are scalability, modularity, coordinated local and global decision making, and the ability to easily implement and test a large variety of decision models.
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Uzukwu, Elochukwu Eugene. "Healing Memories: The church as agent of Reconeiliation In the Service of the Kingdom." Bulletin of Ecumenical Theology, 1997. http://digital.library.duq.edu/u?/bet,676.

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Imperiale, Vita. "Design and formulation of a bespoke self-healing agent for repair of multifunctional fibre reinforced polymers." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582821.

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The aim of this investigation was to design a bespoke self-healing agent (SHA) formulation in order to achieve a fully autonomous healing functionality, which provides effective and timely in-situ repair of FRP composite laminates. The preliminary phase of the design process consisted of the identification of the SHA requirements, the choice of epoxy resins as the most suitable chemistry and, finally, the selection of the best candidate species, amongst the many commercially available. Numerous formulations were then generated by the combination of the above components. Therefore, an initial downselection process, with chemical and physical properties characterisation was necessary to consider only a limited number of formulations for mechanical properties characterization. A Mode I fracture toughness test was considered as a means of final selection, the adhesive function being one of the most important functional requirements. Finally, the recovery of residual compressive strength after impact (CAI) was used as a validation method, which was able to demonstrate and quantify the self-healing recovery within a FRP laminate. A very low viscosity epoxy based formulation with a slightly higher fracture toughness than the host composite matrix and good degree of reactivity was selected as having the best overall performance. Adhesion, as a function of time and temperature, was further assessed in this formulation. It was demonstrated that a certain degree of load bearing ability can be achieved after limited reaction extent with full recovery of load bearing ability after 6 hours at 25°C. An ageing assessment of SHA demonstrated that after seven days exposure to 60°C the formulation possessed excellent adhesive properties. The novel integration of a two-part SHA, with the components segregated within different hollow glass fibres for a fully autonomous process, required the development of a suitable manufacturing and design of the FRP laminate. The damaged and self-healed samples achieved 93% of the strength relative to the initial pristine configuration. Besides an increase in the failure load, self-healing generated a significant change in the stress-strain characteristics, which restored a degree of linearity up to failure, and a reduction in the differential strains (and hence increased buckling resistance). The bleeding of the SHA from storage in the HGF to effect healing can be implied from ultrasonic C-scan analysis, where images of self- healing samples possessed fragmented and less defined delamination contours compared to the image of damaged samples without SHA within hollow glass fibres. This investigation has demonstrated that a fully autonomous recovery of a significant proportion of compressive strength in a CFRP is possible via self-healing. For the first time it has been demonstrated that a bespoke multi-component SHA is able to bleed from embedded HGF, self-mix and react to allow recovery of up to 93% of compressive strength, notwithstanding the presence of remaining damage within the CFRP laminate
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Suurhasko, Kai. "”Jag har alltid trott att det finns något men inte hittat något” : Att leva alternativa diskurser." Thesis, Linköping University, Department of Social Anthropology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9317.

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Uppsatsen handlar om tre informanter som intervjuats angående sin syn på alternativa behandlingar och alternativa diskurser i kontrast till dominerande diskurser inom medicin och samhälle. Viktiga avsnitt rör till exempel sådant som vad är healing, hur kan en behandling gå till, grundläggande synsätt i alternativa diskurser och hur man ser på sjukdom.


This paper is about three informants. I have interviewed them in the context of their views about alternative discourses in contrast to the dominating discourses in medicine and society. Important parts in the paper touch healing, how treatment is carried out, basic thinking in alternative discourses and how disease is perceived?

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Menke, Nathan. "A COMPUTATIONAL BIOLOGY APPROACH TO THE ANALYSIS OF COMPLEX PHYSIOLOGY: COAGULATION, FIBRINOLYSIS, AND WOUND HEALING." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2093.

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The birth of complexity research derives from the logical progression of advancement in the scientific field afforded by reductionist theory. We present in silico models of two complex physiological processes, wound healing and coagulation/fibrinolysis based on two common tools in the study of complex physiology: ordinary differential equations (ODE) and Agent Based Modeling (ABM). The strengths of these two approaches are well-suited in the analysis of clinical paradigms such as wound healing and coagulation. The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve our basic approach to understanding the process. We have modified an existing ordinary differential equation model by 1) evolving from a systemic model to a local model, 2) the incorporation of fibroblast activity, and3) including the effects of tissue oxygenation. Possible therapeutic targets, such as fibroblast death rate and rate of fibroblast recruitment have been identified by computational analysis. This model is a step toward constructing an integrative systems biology model of human wound healing. The coagulation and fibrinolytic systems are complex, inter-connected biological systems with major physiological roles. We present an Agent Based Modeling and Simulation (ABMS) approach to these complex interactions. This ABMS method successfully reproduces the initiation, propagation, and termination of blood clot formation and its lysis in vitro due to the activation of either the intrinsic or extrinsic pathways. Furthermore, the ABMS was able to simulate the pharmacological effects of two clinically used anticoagulants, warfarin and heparin, as well as the physiological effects of enzyme deficiency/dysfunction, i.e., hemophilia and antithrombin III-heparin binding impairment, on the coagulation system. The results of the model compare favorably with in vitro experimental data under both physiologic and pathophysiologic conditions. Our computational systems biology approach integrates reductionist experimental data into a cohesive model that allows rapid evaluation of the effects of multiple variables. Our ODE and AMBS models offer the ability to generate non-linear responses based on known relationships among variables and in silico modeling of mechanistic biological rules on computer software, respectively. Simulations of normal and disease states as well as effects of therapeutic intervention demonstrate the potential uses of computer simulation. Specifically, models may be applied to hypothesis generation and biological advances, discovery of new diagnostic and therapeutic options, platforms to test novel therapies, and opportunities to predict adverse events during drug development. The ultimate aim of such models is creation of bedside simulators that allow personalized, individual medicine; however, a myriad of opportunities for scientific advancement are opened through in silico experimentation.
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Ratti, James A. "INVESTIGATING SMOKE EXPOSURE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) WITH A CALIBRATED AGENT BASED MODEL (ABM) OF IN VITRO FIBROBLAST WOUND HEALING." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5441.

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COPD is characterized by tissue inflammation and impaired remodeling that suggests fibroblast maintenance of structural homeostasis is dysregulated. Thus, we performed in vitro wound healing experiments on normal and diseased human lung fibroblasts and developed an ABM of fibroblasts closing a scratched monolayer using NetLogo to evaluate differences due to COPD or cigarette smoke condensate exposure. This ABM consists of a rule-set governing the healing response, accounting for cell migration, proliferation, death, activation and senescence rates; along with the effects of heterogeneous activation, phenotypic changes, serum deprivation and exposure to cigarette smoke condensate or bFGF. Simulations were performed to calibrate parameter-sets for each cell type using in vitro data of scratch-induced migration, viability, senescence-associated beta-galactosidase and alpha-smooth muscle actin expression. Parameter sensitivities around each calibrated parameter-set were analyzed. This model represents the prototype of a tool designed to explore fibroblast functions in the pathogenesis of COPD and evaluate potential therapies.
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Abdeldayem, Ali I. A. "The effect of synthetic cannabinoids on wound healing of chondrocytes monolayers and pseudo 3D cartilage tissue. Effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6316.

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Studies have been conducted to highlight the anti-inflammatory and immunosuppressive properties of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissue constructs. The effect of different concentrations of the synthetic cannabinoids WIN55, 212-2 (WIN-2), URB602 and HU-308 with and without their antagonists on the wound healing of chondrocyte monolayers was investigated using a simple scratch assay model. The three cannabinoids were found to increase wound healing of chondrocyte monolayers, but at different rates. WIN55, 212-2 at a concentration of 1μM had the highest effect of increasing both migration and proliferation of chondrocytes cultured in a chondrogenic media, which increased the rate of wound closure. It was also found that treating the cells with 2μM of any of the cannabinoids lead to a decrease in cell proliferation and the rate of wound closure. These findings were further investigated, by studying the effect of WIN-2 on nitric oxide (NO) and matrix metalloproteinase-2 (MMP-2) expressed by wounded chondrocyte monolayers. Moreover, expression of collagen type-I, collagen type-II, fibronectin and S100 proteins were detected using immunofluorescence and verified quantitatively using ELISA based techniques, following treatment with 1μM and 2μM of WIN-2, for both 2D monolayers and 3D sheets. Treating chondrocytes with 1μM of WIN-2 significantly increased collagen type-II, fibronectin and S100, and significantly reduced collagen type-I compared to control groups in monolayers and chondrocyte cell sheets. On the other hand, both concentrations of WIN-2 significantly reduced the expression of the inflammation markers NO, and MMP-2, in a dose dependent manner. These findings highlight the potential use of the synthetic cannabinoid for improving the rate of wound closure as well as acting as an antiinflammatory agent, which could be used to enhance tissue engineering protocols aimed at cartilage repair.
Egyptian Government
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Abdeldayem, Ali Ibrahim Al. "The effect of synthetic cannabinoids on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue : effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6316.

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Studies have been conducted to highlight the anti-inflammatory and immunosuppressive properties of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissue constructs. The effect of different concentrations of the synthetic cannabinoids WIN55, 212-2 (WIN-2), URB602 and HU-308 with and without their antagonists on the wound healing of chondrocyte monolayers was investigated using a simple scratch assay model. The three cannabinoids were found to increase wound healing of chondrocyte monolayers, but at different rates. WIN55, 212-2 at a concentration of 1μM had the highest effect of increasing both migration and proliferation of chondrocytes cultured in a chondrogenic media, which increased the rate of wound closure. It was also found that treating the cells with 2μM of any of the cannabinoids lead to a decrease in cell proliferation and the rate of wound closure. These findings were further investigated, by studying the effect of WIN-2 on nitric oxide (NO) and matrix metalloproteinase-2 (MMP-2) expressed by wounded chondrocyte monolayers. Moreover, expression of collagen type-I, collagen type-II, fibronectin and S100 proteins were detected using immunofluorescence and verified quantitatively using ELISA based techniques, following treatment with 1μM and 2μM of WIN-2, for both 2D monolayers and 3D sheets. Treating chondrocytes with 1μM of WIN-2 significantly increased collagen type-II, fibronectin and S100, and significantly reduced collagen type-I compared to control groups in monolayers and chondrocyte cell sheets. On the other hand, both concentrations of WIN-2 significantly reduced the expression of the inflammation markers NO, and MMP-2, in a dose dependent manner. These findings highlight the potential use of the synthetic cannabinoid for improving the rate of wound closure as well as acting as an antiinflammatory agent, which could be used to enhance tissue engineering protocols aimed at cartilage repair.
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Books on the topic "HEALING AGENT"

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Gutman, Jimmy. Glutathione (GSH): Your body's most powerful healing agent. Montréal: G& S Health Books, 2000.

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Sheila, Buff, ed. The GSH phenomenon: Nature's most powerful antioxidant and healing agent. New York: St. Martin's Press, 1997.

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Wilson, Graham Whitelaw. Art as healing agent: Toward a theology of pastoral aesthetics in palliative health care. [Derby: University of Derby], 2003.

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Swinburne, Clymer R. Nature's healing agents: The medicines of nature (or the natura system. Glenwood, Ill: Meyerbooks, 1997.

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Liniger, Dave. My next step: An extraordinary journey of healing and hope. Carlsbad, Calif: Hay House, Inc., 2013.

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Loes, Michael. The Aspirin alternative: The natural way to overcome chronic pain, reduce inflammation and enhance the healing response. Topanga, CA: Freedom Press, 1999.

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The very best painkiller foods: 72 natural foods to ease arthritis and joint pain : 115 healing recipes. Montreal]: Cardinal, 2014.

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M, Bradley, Health Technology Assessment Programme, and National Co-ordinating Centre for HTA (Great Britain), eds. Systematic reviews of wound care management 2: Dressings and topical agents used in the healing of chronic wounds. Alton: Core Research on behalf of the NCCHTA, 1999.

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In the name of Jesus!: Healing in the age of HIV. Geneva, Switzerland: World Council of Churches Publications, 2013.

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David, Steinman, ed. The Aspirin alternative: The natural way to overcome chronic pain, reduce inflammation and enhance the healing response. Topanga, CA: Freedom Press, 1999.

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Book chapters on the topic "HEALING AGENT"

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Oti, Victor B. "Wound Healing: Understanding Honey as an Agent." In Wound Healing Research, 149–76. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2677-7_5.

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Kumar, Manish, V. Vivekanand, and Nidhi Pareek. "Chitooligosaccharides as Wound Healing Agent." In Chitooligosaccharides, 185–201. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92806-3_12.

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Stern, Jordan R., Cordelia Ziraldo, Yoram Vodovotz, and Gary An. "Agent-Based Models of Wound Healing." In Complex Systems and Computational Biology Approaches to Acute Inflammation, 209–28. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8008-2_12.

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Bromuri, Stefano, Michael Ignaz Schumacher, and Kostas Stathis. "Pervasive Healthcare Using Self-Healing Agent Environments." In Advances in Intelligent and Soft Computing, 159–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19917-2_20.

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Valle, Marta, Elisabet Domínguez-Clavé, Matilde Elices, Juan Carlos Pascual, Joaquim Soler, José A. Morales-García, Ana Pérez-Castillo, and Jordi Riba. "Ayahuasca as a Versatile Therapeutic Agent: From Molecules to Metacognition and Back." In Ayahuasca Healing and Science, 1–19. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-55688-4_1.

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Mistry, Maulik, and Santosh Shah. "Concrete with Encapsulated Self-healing Agent: A Critical Review." In RILEM Bookseries, 207–30. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51485-3_14.

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Park, Jeongmin, Hyunsang Youn, and Eunseok Lee. "A Multi-agent Based Context Aware Self-healing System." In Lecture Notes in Computer Science, 515–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11508069_67.

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Kim, Haeng-Kon, and Hyun Yeo. "Self-Healing Multi Agent Prototyping System for Crop Production." In Ambient Intelligence - Software and Applications, 31–43. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07596-9_4.

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Trippel, Stephen B. "Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair." In Advances in Experimental Medicine and Biology, 135–43. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25588-5_10.

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AbstractThe failure of cartilage healing is a major impediment to recovery from jointdisease or trauma. Growth factors play a central role in cell function and have been proposed as potential therapeutic agents to promote cartilage repair. Decades of investigation have identified many growth factors that promote the formation of cartilage in vitro and in vivo. However, very few of these have progressed to human trials. A growth factor that robustly augments articular cartilage healing remains elusive. This is not surprising. Articular cartilage repair involves multiple cellular processes and it is unlikely that any single agent will be able to optimally regulate all of them. It is more likely that multiple regulatory molecules may be required to optimize the maintenance and restoration of articular cartilage. If this is the case, then interactions among growth factors may be expected to play a key role in determining their therapeutic value. This review explores the hypothesis that growth factor interactions could help optimize articular cartilage healing.
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Murari, Krishna, and Pritpal Kaur. "Development of Sustainable Concrete Using Bacteria as Self-healing Agent." In Lecture Notes in Civil Engineering, 693–700. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9554-7_62.

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Conference papers on the topic "HEALING AGENT"

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Imperiale, Vita, and Ian Bond. "A Novel Self-Healing Agent for Autonomous Healing in FRPs." In 49th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference
16th AIAA/ASME/AHS Adaptive Structures Conference
10t. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2008. http://dx.doi.org/10.2514/6.2008-1740.

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Rae, S. I., I. P. Bond, R. S. Trask, and D. F. Wass. "Novel Self-Healing Systems: Expanding and Inhibited Healing Agents." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7637.

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A new approach to self-healing systems is presented that aims to overcome the inherent drawbacks of conventional liquid resin based healing systems within composites. Finite embedded systems offer limited healing potential for small volume delaminations and as such cannot effectively heal large damage volumes often associated with shear damaged sandwich panel structures or debonding between skin and core. An expanding polymer based approach aims to overcome such limitations. The mechanical and physical properties of a prepared polyepoxide foam are investigated and how the inclusion of a carbon fibre reinforcement within the foam affects processability and performance. The healing efficiency of different polymer foams to heal damaged structures is also investigated. A secondary investigation is also presented that aimed to overcome the drawbacks associated with the requirement for stoichiometric mixing of two part healing agents, or for healing agent to come into direct contact with a catalyst embedded within the matrix material. Different approaches were taken to develop a self-healing system that once deployed required no additional mixing or stimuli for healing to occur.
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Falou, Mohamad EL, Maroua Bouzid, Abdel-Illah Mouaddib, and Thierry Vidal. "A Self Healing Action Composition Agent." In 2011 IEEE 23rd International Conference on Tools with Artificial Intelligence (ICTAI 2011). IEEE, 2011. http://dx.doi.org/10.1109/ictai.2011.90.

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Nakao, Wataru. "Advanced Self-Healing Ceramics for Turbine Blade." In ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3235.

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Advanced fiber reinforced ceramic composite having self-healing function (shFRC) has been developed. The composite includes the silicon carbide interlayer as healing agent at the interface between alumina fiber and alumina matrix. The healing agent interlayer caused the preferential fracture of the fiber/matrix interface and the interface fracture gave rise to the slip of the interface during crack propagation. Thereby the shFRC could exhibit a large deformation at the fracture and large fracture energy. Moreover, the high temperature oxidation of the healing agent made the interface delimitation rebounded by the formed oxide and the reaction heat. As a result, the maximum strength and the stiffness degraded by the interface delimitation could be recovered by the healing. Consequently, it was found that the shFRC containing the interlayer of the healing agent can survive the repeated crack propagation or initiation due to the large impact damage.
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Martinez Lucci, Jose, R. S. Amano, and Pradeep Rohatgi. "Computational Analysis of Self-Healing in a Polymer Matrix With Microvascular Networks." In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-50148.

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For the last decade, many researchers have been working to develop self-healing materials, and have obtained good results in the field of polymers, these components with microencapsulated healing agent have exhibited noticeable mechanical performance and regenerative property The research described in this paper applies the concept of self healing to simulate self healing polymer matrix composites, with the aid of models developed by the authors for the manufacturing processes and self-healing behavior. The development of self-healing is a novel idea that has not been totally explored in great detail yet. The concept of self-healing described in this paper consists of simulation of a healing agent dicyclopentadiene (DCPD) inside of a microvascular network within a polymer matrix coating with catalyst forming a self-healing composite (SHC). When this SHC is damaged or cracked, the healing agent by capillary action will flow inside of the microvascular network; when the liquid enter in contact with the catalyst will form a polymer structure and sealing the crack. The study consists of theoretical analysis and Computational Fluid Dynamics of a self-healing polymer. The objective of the study reported here was to find the influence and efficiency of the microvascular network in healing a polymer matrix. To check this effect a computational model was created to simulate the healing treatment, thus a crack was created on the matrix surface piercing the microvascular network filled with healing agent and the method to simulate healing behavior of the composite allows assessment of the effects of the autonomously repairing repeated damage events.
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Gupta, Ruchi, Deependra Kumar Jha, Vinod Kumar Yadav, and Sanjeev Kumar. "A multi-agent based self-healing smart grid." In 2013 IEEE PES Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2013. http://dx.doi.org/10.1109/appeec.2013.6837306.

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Chopra, I., and M. Singh. "Agent based self-healing system for grid computing." In ICWET '10: International Conference and Workshop on Emerging Trends in Technology. New York, NY, USA: ACM, 2010. http://dx.doi.org/10.1145/1741906.1741912.

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Zhang, Xiaohong, Huiqin Wang, and Shangfu Gong. "Network Self-healing Algorithm Based on Mobile Agent." In 2010 International Conference on E-Business and E-Government (ICEE). IEEE, 2010. http://dx.doi.org/10.1109/icee.2010.523.

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"Extruded Cementitious Hollow Tubes For Healing Agent Delivery." In SP-305: Durability and Sustainability of Concrete Structures. American Concrete Institute, 2015. http://dx.doi.org/10.14359/51688574.

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Makenan, Siti Mastura, and Mohd Suzeren Md Jamil. "Effect of using miscible and immiscible healing agent on solid state self-healing system." In THE 2014 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4895210.

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Reports on the topic "HEALING AGENT"

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Judd, Amrit K. Development of a Therapeutic Agent for Wound-Healing Enhancement. Fort Belvoir, VA: Defense Technical Information Center, May 1992. http://dx.doi.org/10.21236/ada251852.

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Judd, Amrit K. Development of a Therapeutic Agent for Wound-Healing Enhancement. Fort Belvoir, VA: Defense Technical Information Center, June 1992. http://dx.doi.org/10.21236/ada252021.

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Huang, Cihang, Yen-Fang Su, and Na Lu. Self-Healing Cementitious Composites (SHCC) with Ultrahigh Ductility for Pavement and Bridge Construction. Purdue University, 2021. http://dx.doi.org/10.5703/1288284317403.

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Cracks and their formations in concrete structures have been a common and long-lived problem, mainly due to the intrinsic brittleness of the concrete. Concrete structures, such as rigid pavement and bridge decks, are prone to deformations and deteriorations caused by shrinkage, temperature fluctuation, and traffic load, which can affect their service life. Rehabilitation of concrete structures is expensive and challenging—not only from maintenance viewpoints but also because they cannot be used for services during maintenance. It is critical to significantly improve the ductility of concrete to overcome such issues and to enable better infrastructure quality. To this end, the self-healing cementitious composites (SHCC) investigated in this work could be a promising solution to the aforementioned problems. In this project, the team has designed a series of cementitious composites to investigate their mechanical performances and self-healing abilities. Firstly, various types of fibers were investigated for improving ductility of the designed SHCC. To enhance the self-healing of SHCC, we proposed and examined that the combination of the internal curing method with SHCC mixture design can further improve self-healing performance. Three types of internal curing agents were used on the SHCC mixture design, and their self-healing efficiency was evaluated by multiple destructive and non-destructive tests. Results indicated a significant improvement in the self-healing capacity with the incorporation of internal curing agents such as zeolite and lightweight aggregate. To control the fiber distribution and workability of the SHCC, the mix design was further adjusted by controlling rheology using different types of viscosity modifiers. The team also explored the feasibility of the incorporation of colloidal nano-silica into the mix design of SHCC. Results suggest that optimum amounts of nano-silica have positive influence on self-healing efficiency and mechanical properties of the SHCC. Better hydration was also achieved by adding the nano-silica. The bonding strength of the SHCC with conventional concrete was also improved. At last, a standardized mixing procedure for the large scale SHCC was drafted and proposed.
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Cabrera, Anahi Maldonado, Blayra Maldonado Cabrera, Dalia Isabel Sánchez Machado, and Jaime López Cervantes. Wound healing therapeutic effect of chitosan nanofibers: a systematic review and meta- analysis of animal studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0121.

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Review question / Objective: Review question: Does chitosan base nanofibers has significant wound healing therapeutics effects in animal models? A preclinical systematic review of intervention will be carried out to evaluate the therapeutic effects of chitosan nanofibers on animal skin lesions. The PICO (Population, Intervention, Comparator, Outcome) scheme will be used: Intervention: full-thickness skin lesions, and the application of chitosan nanofibers as treatment for animal skin lesions. Regardless of the concentration of chitosan or other added compounds used. Comparison: No intervention, topical placebo agents and standard skin lesions treatments will be included. Outcome: wound healing area, wound closure, type of wound closure (first, second or third intention), healing time, infectious processes (antibacterial/antifungal properties), blood loss (hemostatic properties) and adverse effects.
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