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1

Hodson, Jean, and Farook Al-Azzawi. "The Frequency and Pattern of Headache in Menopausal Women." British Menopause Society Journal 4, no. 2 (June 1998): 61–64. http://dx.doi.org/10.1177/136218079800400208.

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Objective To assess the frequency and pattern of headache in perimenopausal women. Study design A questionnaire survey performed on 200 consecutive women attending Leicester Royal Infirmary menopause clinic during May 1997. Main outcome measures The main areas considered included frequency, duration and severity of headache, type and effectiveness of treatment used, interference with daily activities, and the effect of menopause and HRT on headache. Results 38 women (19%) never experienced headaches whereas 158 (79%) reported recurrent headaches. The majority of these women (106) reported at least one headache in the preceding week with a small number (9) reporting daily headache. Stress (106), tiredness (75) and menstrual cycle (54) were common trigger factors. Most women used simple analgesics for treatment with few using sumatriptan (4) or prophylactic therapy (9). Women were not asked to classify headache but 18 (9%) reported vomiting and are likely to represent the minimum incidence of migraine. Headaches produced considerable morbidity and interference with daily activities social events and work. The effect of menopause and HRT (99 users) on headache was assessed and a group of “hormone sensitive” women identified. Conclusion The problem of menopausal headache is substantial; it is probably under-estimated, under-treated and poorly understood. It certainly deserves further attention.
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Schwedt, Todd J., Robert W. Gereau, Karen Frey, and Evan D. Kharasch. "Headache outcomes following treatment of unruptured intracranial aneurysms: A prospective analysis." Cephalalgia 31, no. 10 (March 11, 2011): 1082–89. http://dx.doi.org/10.1177/0333102411398155.

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Objective: To analyze headache patterns prior to and following treatment of unruptured intracranial aneurysms and identify factors associated with different headache outcomes. Methods: A prospective observational study of patients being treated for unruptured intracranial aneurysms. Headache patterns were established prior to aneurysm treatment and for 6 months following treatment. Factors associated with different headache outcomes were investigated. Results: In all patients ( n = 44), 90-day headache frequency decreased from an average of 31 days prior to aneurysm treatment to 17 days following treatment ( p < 0.001). In patients with active pretreatment headaches ( n = 28), 90-day headache frequency decreased from 49 days to 26 days ( p = 0.002). Headache frequency was reduced in 68% of patients, while 9% of patients had new or worsened headaches following aneurysm treatment. Pretreatment migraine, more severe pretreatment headaches, higher pretreatment trait anxiety, and stent-assisted aneurysm coiling were associated with a lack of headache improvement. Conclusions: The majority of patients with headaches at the time of aneurysm treatment had reductions in headache frequency during the 6 months following treatment. Potential risk factors for poor headache outcomes were identified but need to be studied further.
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3

Walach, H., W. Haeusler, T. Lowes, D. Mussbach, U. Schamell, W. Springer, G. Stritzl, W. Gaus, and G. Haag. "Classical Homeopathic Treatment of Chronic Headaches." Cephalalgia 17, no. 2 (April 1997): 119–26. http://dx.doi.org/10.1046/j.1468-2982.1997.1702119.x.

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We conducted a randomized, placebo-cor rolled, double-blind clinical trial in order to determine the efficacy of classical homeopathic therapy in patients with chronic headaches. After 6 weeks of baseline observation, patients received either the prescribed individualized homeopathic medication or an indistinguishable placebo for 12 weeks. Outcome parameters were headache frequency, duration, and intensity, measured daily by diary. Use of medication for acure headache was also monitored. Of the 98 patients in the sample, 37 were randomized to receive placebo, 6I received individualized homeopathic remedies. Groups were comparable at the beginning of the treatment. The median age was 48.5 years; 76% suffered from migraine, 51% from tension-type headaches, and 94% were previously treated for headache. The median headache frequency was 3 days a week. Headaches were present for 23 years (median). In both groups, patients showed an improvement of one headache day less per month. The use of medication for acute headache was reduced. The headache frequency of 11 patients was reduced by more than 40%. Thirty-nine patients either did not improve or experienced aggravations. There was no significant difference in any parameter between homeopathy and placebo.
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Zeeberg, P., J. Olesen, and R. Jensen. "Efficacy of Multidisciplinary Treatment in a Tertiary Referral Headache Centre." Cephalalgia 25, no. 12 (December 2005): 1159–67. http://dx.doi.org/10.1111/j.1468-2982.2005.00980.x.

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Despite the high prevalence of headaches, multidisciplinary headache clinics are few and their efficacy still needs validation. We set out to describe the procedures, characterize the patients and evaluate the treatment results in Danish Headache Centre. All clinical records for patients discharged in 2002 were systematically reviewed. Diagnoses were classified in accordance with ICHD-II. Outcome results were analysed with respect to headache diagnoses, frequency, intensity, absence from work and medication use. Five hundred and five patients were included and 336 were eligible for the study. Mean age was 46 years and male/female ratio 1 : 2.4. For patients without medication overuse headache (MOH) a reduction in headache frequency (P < 0.01) and intensity ( P < 0.05) was seen for frequent episodic and chronic tension-type headache (TTH), migraine, cluster and other headaches. No reduction was seen in post-traumatic headache. Absence from work decreased significantly for migraine ( P < 0.001) and frequent episodic TTH (P < 0.05). For patients with MOH a reduction in headache frequency was seen for TTH and migraine ( P < 0.001). A specialized headache centre is valuable in treatment of patients with complex headache disorders.
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Kelman, L. "The Aura: A Tertiary Care Study of 952 Migraine Patients." Cephalalgia 24, no. 9 (September 2004): 728–34. http://dx.doi.org/10.1111/j.1468-2982.2004.00748.x.

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The aim of this study was to document the frequency and types of aura symptoms, to define the relationship between aura symptoms and to define the aura frequency in different migraine types. In 952 migraine patients, aura frequency, duration, time to headache, characteristics and percentage of headaches with aura were analysed. Thirty-eight percent of IHS 1.1-1.5 patients reported aura, 38.1% of females and 33.0% of males. Average percentage of aura occurrence with headache was 19.7% of headaches, average aura duration 27.3 min and aura was followed by headache in 10.4 min on average. Visual disturbances occurred in 92.1% and aura without visual aura was rare. Aura frequency was headache-type dependent. The highest frequency of aura was seen in the more ‘full-blown’ migraine attack. Visual aura is the overwhelming aura symptom. Even in patients with aura the percentage of aura with migraine attacks is limited.
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Rocha-Filho, PAS, JLD Gherpelli, JTT de Siqueira, and GD Rabello. "Post-craniotomy headache: A proposed revision of IHS diagnostic criteria." Cephalalgia 30, no. 5 (October 1, 2009): 560–66. http://dx.doi.org/10.1111/j.1468-2982.2009.02010.x.

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Seventy-nine patients with intracranial aneurysms were evaluated in the presurgical period, and followed up to 6 months after surgery. We compare patients who fulfilled with those that did not post-craniotomy headache (PCH) diagnostic criteria, according to the International Classification of Headache Disorders. Semistructured interviews, headache diaries, Short Form-36 and McGill Pain Questionnaire were used. Seventy-two patients (91%) had headaches during the follow-up period. The incidence of PCH according to the International Headache Society diagnostic criteria was 40%. Age, sex, type of surgery, temporomandibular disorder, vasospasm, presence and type of previous headaches, and subarachnoid haemorrhage were not related to headache classification. There were no differences in the quality of life, headache frequency and characteristics or pain intensity between patients with headache that fulfilled or not PCH criteria. We proposed a revision of the diagnostic criteria for PCH, extending the headache outset after surgery from 7 to 30 days, and including the presence of headaches after surgery in patients with no past history of headaches, or an increase in headache frequency during the first 30 days of the postsurgical period followed by a decrease over time. Using these criteria we would classify 65% of our patients as having PCH.
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7

Sampaio Rocha-Filho, Pedro Augusto, and João Eudes Magalhães. "Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia." Cephalalgia 40, no. 13 (November 2020): 1443–51. http://dx.doi.org/10.1177/0333102420966770.

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Objectives To assess the frequency and characteristics of headache in patients with COVID-19 and whether there is an association between headache and anosmia and ageusia. Methods This was a cross-sectional study. Consecutive patients admitted to hospital with COVID-19, confirmed by reverse transcription polymerase chain reaction (RT-PCR) technique, were assessed by neurologists. Results Seventy-three patients were included in the study, 63% were male; the median age was 58 years (IQR: 47–66). Forty-seven patients (64.4%) reported headaches, which had most frequently begun on the first day of symptoms, were bilateral (94%), presenting severe intensity (53%) and a migraine phenotype (51%). Twelve patients (16.4%) presented with headache triggered by coughing. Eleven (15%) patients reported a continuous headache. Twenty-eight patients (38.4%) presented with anosmia and 29 (39.7%) with ageusia. Patients who reported hyposmia/anosmia and/or hypogeusia/ageusia experienced headache more frequently than those without these symptoms (OR: 5.39; 95% CI:1.66–17.45; logistic regression). Patients with anosmia and ageusia presented headache associated with phonophobia more often compared to those with headache without these complaints (Chi-square test; p < 0.05). Headache associated with COVID-19 presented a migraine phenotype more frequently in those experiencing previous migraine ( p < 0.05). Conclusion Headaches associated with COVID-19 are frequent, are generally severe, diffuse, present a migraine phenotype and are associated with anosmia and ageusia.
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Miller, Vanessa E., Keturah R. Faurot, Olafur S. Palssson, Beth A. MacIntosh, Chirayath Suchindran, Gilson Honvoh, Susan Gaylord, Christopher E. Ramsden, and J. Douglas Mann. "Comparing prospective headache diary and retrospective four-week headache questionnaire over 20 weeks: Secondary data analysis from a randomized controlled trial." Cephalalgia 40, no. 13 (August 16, 2020): 1523–31. http://dx.doi.org/10.1177/0333102420949180.

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Background Headache diaries and recall questionnaires are frequently used to assess headache frequency and severity in clinical and research settings. Methods Using 20 weeks of data from an intervention trial with 182 participants, we evaluated concordance between an electronic headache diary administered on a daily basis and designed to capture the presence and severity of headaches on an hourly basis (the headache diary) and a recall questionnaire, with retrospective estimation of the number of headache days assessed on a monthly basis. We further examined whether the duration or severity of headaches assessed by the electronic diary impacted concordance between these two measures. Results Over the course of four 28-day periods, people with migraine participating in a dietary intervention reported an average of 13.7 and 11.1 headache days in the headache diary and recall questionnaire, respectively. Conclusion Over time, the concordance between headache days reported in these two measures tended to increase; however, the recall questionnaire headache estimates were lower than the diary measures in all four periods. When analysis was restricted to headaches lasting 8 hours or more, the number of headache days was more closely aligned with days reported in the recall questionnaire, indicating that the accuracy of recall estimates is likely to be influenced by headache duration. Restriction of analyses to moderate-to-severe headaches did not change results as much as headache duration. The findings indicate that recall questionnaires administered on a monthly basis may underestimate headache frequency and therefore should not be used interchangeably with headache diaries. Clinical Trials.gov Identifier: NCT02012790
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Stuginski-Barbosa, Juliana, and José Geraldo Speciali. "Frequency of headache among the employees of a rubber company in the state of São Paulo, Brazil." Sao Paulo Medical Journal 129, no. 2 (March 2011): 66–72. http://dx.doi.org/10.1590/s1516-31802011000200003.

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CONTEXT AND OBJECTIVE: Primary headaches may be responsible for absenteeism and a fall in the yield and productivity of work. The aim of this study was to establish the presence and frequency of primary headache among employees of a rubber shoe sole company, and its link to absenteism. DESIGN AND SETTING: Cross-sectional study carried out with help from the staff of the medical and social department of a rubber factory located in the municipality of Franca, São Paulo. METHOD: A questionnaire on headache characteristics was distributed to all employees. The returned and completed questionnaires were divided into two groups: with and without reports of headache. The headaches were classified into four main groups: migraine, tension-type headache (TTH), cluster headache and others. In terms of the reported frequency, headaches were also classified as chronic daily headache (CDH). RESULTS: The number of valid questionnaires was 392 (59%); 80.9% were from male and 19.1% from female employees. Headaches were reported by 120 subjects (30.6%), with 17.4% belonging to the migraine group and 8.9% to the TTH group. Migraine was more frequent (p < 0.001) among all participants and also among the women (p < 0.05). TTH was more frequent among the men (p < 0.05). CDH was identified in 14 individuals (3.6%). CONCLUSIONS: Headache was a common problem among the employees of this company and was a cause of absenteeism for 8.7% of the respondents to the questionnaire.
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10

Scharff, L., DC Turk, and DA Marcus. "Psychosocial and Behavioral Characteristics in Chronic Headache Patients: Support for a Continuum and Dual-Diagnostic Approach." Cephalalgia 15, no. 3 (June 1995): 216–23. http://dx.doi.org/10.1046/j.1468-2982.1995.015003216.x.

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The present study attempted to identify psychological differences among different headache diagnoses defined by IHS criteria as well as psychological differences by headache intensity and frequency. Differences between diagnostic categories reflected characteristics used to assign diagnoses, namely the constancy of pain and distracting behaviors of significant others due to isolating behavior from photophobia and phonophobia. A rating of headache intensity and frequency was a more powerful predictor of psychological ratings than diagnosis. Diagnosis was related to headache frequency but not intensity. The results suggest that a continuum diagnosis based on severity can be useful in conceptualizing headaches, and a dual-diagnostic system integrating headache characteristics with perceptions and coping ability would be helpful in determining treatment options.
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Zwart, J.-A., G. Dyb, TL Holmen, LJ Stovner, and T. Sand. "The Prevalence of Migraine and Tension-Type Headaches Among Adolescents in Norway. The Nord-Trøndelag Health Study (Head-Hunt-Youth), A Large Population-Based Epidemiological Study." Cephalalgia 24, no. 5 (May 2004): 373–79. http://dx.doi.org/10.1111/j.1468-2982.2004.00680.x.

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The aim of this study was to examine the prevalence of headache and primary headache disorders like migraine and tension-type headaches among adolescents, and to explore the differences in headache prevalence and frequency by gender and age. This cross-sectional study was conducted in Nord-Trøndelag county, Norway, during the years 1995-97. In total, 8984 (88%) out of 10 202 invited adolescents aged 12-19 years participated in the youth part of the Nord-Trøndelag Health Study [Helseundersøkelsen i Nord-Trøndelag (HUNT)]. The total study population in this study consisted of 8255 individuals after exclusion of invalid questionnaires and students outside the target range of 13-18 years of age. The students completed a comprehensive questionnaire, and one of the questions was whether the students had experienced any headaches during the last 12 months. In addition, 5847 of these students were also subject to an interview in which they were asked whether they had experienced recurring headaches during the last year and, if so, were they classified as migraine (MI), tension-type headache (TTH) or non-classifiable headache. In the total questionnaire-based population, 76.8% reported having had headaches during the last 12 months (69.4% boys and 84.2% girls). Among those who also were interviewed, 29.1% reported having recurrent headaches (21.0% boys and 36.5% girls). The overall 1-year prevalence of migraine was 7%, of tension-type headache 18%, and of non-classifiable headache 4.8%. Higher prevalence rates were found for girls in all age groups and for all headache categories. The overall frequency of recurrent headaches did not vary significantly with age, but girls had significantly more frequent headaches than boys. We concluded that headache in general, and recurrent primary headache disorders like migraine and tension-type headaches, are common somatic complaints among Norwegian adolescents, especially among girls.
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Parfenov, V. A., T. M. Ostroumova, and O. D. Ostroumova. "Hypertension and Headache: the Effect of Antihypertensive Drugs." Rational Pharmacotherapy in Cardiology 15, no. 3 (July 6, 2019): 416–23. http://dx.doi.org/10.20996/1819-6446-2019-15-3-416-423.

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Headache is considered to be one of the main symptoms of arterial hypertension (HT). Complaints of headache are presented by many patients with HT: from 44% to 87%. It is obvious that the majority of complaints of headache in patients with HT is not due to headaches due to increased blood pressure (BP), but multimorbidity (polymorbidity) – the presence of coexisting primary headaches, most often, as in the population as a whole, chronic tension headache (57-85%) and migraine (15-30%). On the other hand, the frequency of HT in patients with migraine ranges from 32% to 44%. The relationship between migraine and HT may be due to common exogenous (external) and endogenous (genetic) factors, as well as common pathophysiological mechanisms. External risk factors, which can be associated with both migraine and HT, include the nature of the diet (excessive consumption of table salt with food), low physical activity, chronic stress; both diseases are also associated with the presence of a connection with the metabolic syndrome. The role of hyperactivation of the renin-angiotensin-aldosterone and adrenergic system and endothelial dysfunction are actively discussed. Angiotensin-converting enzyme takes an active part in the BP control and vascular tone; it is known that some angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) have demonstrated efficacy in preventing migraine attacks. The presence of HT can contribute to the chronic course of primary headache, and effective treatment of HT with antihypertensive drugs, on the contrary, can have a positive effect on the course of primary headaches. Antihypertensive drugs reduce the frequency of headaches compared to placebo, but heterogeneity between different classes was revealed. There was a statistically significant decrease in the frequency of headaches compared to placebo during treatment with beta-blockers, ACEI, ARB, diuretics, while calcium antagonists did not reduce the frequency of headaches. According to a number of studies, the frequency of headaches during the treatment with ARB (candesartan) is comparable to that in the placebo group. Some antihypertensive drugs are used to prevent migraine attacks.
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Schnider, P., S. Aull, C. Baumgartner, A. Marterer, C. Wöber, K. Zeiler, and P. Wessely. "Long-Term Outcome of Patients with Headache and Drug Abuse after Inpatient Withdrawal." Cephalalgia 16, no. 7 (November 1996): 481–85. http://dx.doi.org/10.1046/j.1468-2982.1996.1607481.x.

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Thirty-eight patients with “chronic daily” headache and ergotamine and/or analgesics abuse according to the criteria proposed by the international Headache Society were re-investigated 5 years after inpatient drug withdrawal. At the end of the observation period, 19 patients (50.0%) had their headaches on only 8 days per month or less, 18 patients (47.4%) were free of symptoms or had only mild headaches. A close correlation was found between the frequency of headache and the duration of drug abuse, as well as between the intensity of headache and the number of tablets taken per month. Frequency and intensity of headache had changed within the first 2 years after withdrawal, but remained stable afterwards. Fifteen patients (39.5%) reported on recurrent drug abuse. Patients with migraine showed a tendency towards a better prognosis compared to patients with tension-type headache or with combined migraine and tension-type headache. The results of this study highlight the long-term efficacy of inpatient drug withdrawal in patients with headache and ergotamine and/or analgesics abuse.
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Wänman, Anders, and Göran Agerberg. "Headache and Dysfunction of the Masticatory System in Adolescents." Cephalalgia 6, no. 4 (December 1986): 247–55. http://dx.doi.org/10.1046/j.1468-2982.1986.0604247.x.

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An epidemiologic group of 285 17–year-old adolescents was studied with the aid of a questionnaire for frequency and intensity of headache and for symptoms of dysfunction of the masticatory system. They were also subjected to a functional examination of the masticatory system. Recurrent headaches occurred significantly more often among the girls (18%) than the boys (6%). Girls also reported significantly more intense headaches than boys. Fatigue in the jaws and difficulties in chewing were commoner in those with frequent and more intensive headaches. Tenderness to palpation of the masticatory muscles and impaired mandibular mobility were significantly commoner findings among those with recurrent headaches and those with more intense headaches. Tooth-grinding and clenching were related to frequency but not to intensity of headache. The investigation showed a significant relationship between frequency and intensity of headaches and signs and symptoms of dysfunction of the masticatory system.
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Scher, Ann I., Paul B. Rizzoli, and Elizabeth W. Loder. "Medication overuse headache." Neurology 89, no. 12 (August 18, 2017): 1296–304. http://dx.doi.org/10.1212/wnl.0000000000004371.

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It is a widely accepted idea that medications taken to relieve acute headache pain can paradoxically worsen headache if used too often. This type of secondary headache is referred to as medication overuse headache (MOH); previously used terms include rebound headache and drug-induced headache. In the absence of consensus about the duration of use, amount, and type of medication needed to cause MOH, the default position is conservative. A common recommendation is to limit treatment to no more than 10 or 15 days per month (depending on medication type) to prevent headache frequency progression. Medication withdrawal is often recommended as a first step in treatment of patients with very frequent headaches. Existing evidence, however, does not provide a strong basis for such causal claims about the relationship between medication use and frequent headache. Observational studies linking treatment patterns with headache frequency are by their nature confounded by indication. Medication withdrawal studies have mostly been uncontrolled and often have high dropout rates. Evaluation of this evidence suggests that only a minority of patients required to limit the use of symptomatic medication may benefit from treatment limitation. Similarly, only a minority of patients deemed to be overusing medications may benefit from withdrawal. These findings raise serious questions about the value of withholding or withdrawing symptom-relieving medications from people with frequent headaches solely to prevent or treat MOH. The benefits of doing so are smaller, and the harms larger, than currently recognized. The concept of MOH should be viewed with more skepticism. Until the evidence is better, we should avoid dogmatism about the use of symptomatic medication. Frequent use of symptom-relieving headache medications should be viewed more neutrally, as an indicator of poorly controlled headaches, and not invariably a cause.
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Al-Hashel, Jasem Yousef, Samar Farouk Ahmed, and Raed Alroughani. "Prevalence of Primary Headache Disorders in Kuwait." Neuroepidemiology 48, no. 3-4 (2017): 138–46. http://dx.doi.org/10.1159/000478892.

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Background: Only an insignificant quantum of data exists on the prevalence of primary headaches among those living in Kuwait. We aimed to determine the prevalence of primary headaches among the Kuwaiti population. Methods: This community-based study included Kuwaiti population aged 18-65 years. Using systematic random sampling, data was collected by the Headache-Attributed Restriction, Disability, Social Handicap and Impaired Participation questionnaire. Responses to the diagnostic questions were transformed into diagnoses algorithmically to confirm the diagnosis of primary headache. Results: A total of 15,523 patients were identified of whom 9,527 (61%) were diagnosed with primary headache disorder; a female predominance of 62.2% was observed. The mean age was 34.84 ± 10.19. Tension-type headache (TTH) was the most prevalent at 29% followed by episodic migraine (23.11%), chronic migraine (5.4%), and medication overuse headache (2.4%). Primary headache prevalence declined steadily from 71% in those aged 18-30 years to 23% in those over 50 (p < 0. 037). The female:male ratio was 1.7:1. Frequency and severity of primary headache were correlated significantly with lost work days (r = 0.611, p < 0.001 and r = 0.102, p = 0.001, respectively). Conclusions. In Kuwait, primary headache disorder is more frequent in young adults and females. TTH followed by episodic migraine were the more prevalent types of headache. Higher frequency and severe headaches were associated with increasing social and work-related burden.
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de Tommaso, M., M. Sardaro, C. Serpino, F. Costantini, F. Vecchio, M. Pia Prudenzano, P. Lamberti, and P. Livrea. "Fibromyalgia Comorbidity in Primary Headaches." Cephalalgia 29, no. 4 (April 2009): 453–64. http://dx.doi.org/10.1111/j.1468-2982.2008.01754.x.

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Fibromyalgia syndrome (FMS) is a chronic pain condition of unknown aetiology characterized by diffuse pain and tenderness at tender points. The aim of the study was to assess the prevalence and clinical features of FMS in the different forms of primary headaches, in a tertiary headache centre. Primary headache patients ( n = 217) were selected and submitted to the Total Tenderness Score, anxiety and depression scales, Migraine Disability Assessment, allodynia questionnaire, Short Form 36 Health Survey and the Medical Outcomes Study-Sleep Scale. In patients with FMS, the Multidimensional Assessment of Fatigue, the Pain Visual Analog Scale, the Manual Tender Point Survey and the Fibromyalgia Impact Questionnaire were employed. FMS was present in 36.4% of patients and prevailed significantly in tension-type headache and in patients with higher headache frequency. Headache frequency, pericranial muscle tenderness, anxiety and sleep inadequacy were especially associated with FMS comorbidity. In the FMS patients, fatigue and pain at tender points were significantly correlated with headache frequency. FMS seems increasingly prevalent with increased headache frequency, for the facilitation of central sensitization phenomena favoured by anxiety and sleep disturbances.
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Finn, Thomas, Raymond DiGiuseppe, and Clayton Culver. "The Effectiveness of Rational-Emotive Therapy in the Reduction of Muscle Contraction Headaches." Journal of Cognitive Psychotherapy 5, no. 2 (January 1991): 93–103. http://dx.doi.org/10.1891/0889-8391.5.2.93.

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The study tested the effectiveness of RET in treating muscle contraction headaches. Thirty-five adult subjects diagnosed as muscle contraction headache sufferers completed one of four treatment conditions: Rational-Emotive Therapy (RET); Progressive muscle relaxation (PMR); Headache discussion (HAD), which discussed historical roots of symptoms and monitored cognitive responses but learned no specific coping techniques; and a Waiting list symptom monitoring group (WLC). Dependent measures consisted of data on each subject’s weekly headache duration, frequency, severity, and number of headache-free days. These measures were derived from a daily headache diary. Frontalis EMG was also measured. After a treatment program of 10 weekly one-and-one-half-hour group therapy sessions, both the RET and PMR groups had significantly lower headache severity scores, headache frequency, than the HAD and WLC groups. While changes in headache duration and headache-free days were not significant, patterns of these means were consistent with the other measures showing a decrease in headache pathology. At follow-up, ratings of headache improvement done by each subject and by a significant other showed the RET group reported greater improvement than the PMR and HAD groups, which did not differ. The results suggest that RET and PMR were equally effective in the treatment of muscle contraction headaches.
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Heckman, BD, KA Holroyd, G. Tietjen, FJ O'Donnell, L. Himawan, C. Utley, R. Watakakosol, and M. Stillman. "Whites and African-Americans in Headache Specialty Clinics Respond Equally Well to Treatment." Cephalalgia 29, no. 6 (June 2009): 650–61. http://dx.doi.org/10.1111/j.1468-2982.2008.01785.x.

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This study sought to determine if Whites and African-Americans respond similarly to headache treatment administered in ‘real-world’ headache specialty treatment clinics. Using a naturalistic, longitudinal design, 284 patients receiving treatment for headache disorders completed 30–day daily diaries that assessed headache frequency and severity at pretreatment and 6–month follow-up and also provided data on their headache disability and quality of life at pretreatment and 1–, 2– and 6–month follow-up. Controlling for socioeconomic status and psychiatric comorbidity, hierarchical linear models found that African-Americans and Whites reported significant reductions in headache frequency and disability and improvements in life quality over the 6–month treatment period. African-Americans, unlike Whites, also reported significant decreases in headache severity. Nevertheless, Africans-Americans had significantly more frequent and disabling headaches and lower quality of life after treatment relative to Whites. Although Whites and African Americans responded favourably to headache treatments, more efficacious treatments are needed given the elevated level of headache frequency that remained in both racial groups following treatment.
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Domingues, Renan B., Halina Duarte, Carlos Senne, Gustavo Bruniera, Fernando Brunale, Natália P. Rocha, and Antonio L. Teixeira. "Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients." Arquivos de Neuro-Psiquiatria 74, no. 8 (August 2016): 626–31. http://dx.doi.org/10.1590/0004-282x20160096.

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ABSTRACT Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
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Constantinides, Vasilios, Evangelos Anagnostou, Anastasia Bougea, George Paraskevas, Elisavet Kapaki, Ioannis Evdokimidis, and Evangelia Kararizou. "Migraine and tension-type headache triggers in a Greek population." Arquivos de Neuro-Psiquiatria 73, no. 8 (August 2015): 665–69. http://dx.doi.org/10.1590/0004-282x20150093.

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Migraine and tension type headache are the two most common primary headaches. The purpose of this study was to detect differences in clinical characteristics and headache triggers and in a Greek cohort of 51 migraineurs and 12 patients with tension-type headache. (TTH) Migraine patients had a significantly lower age at headache onset and frequency, higher mean visual analogue scale (VAS) and greater maximum duration of headache episodes compared to TTH patients. They did not differ from (TTH) patients in quality of headache, laterality of pain, way of headache installation and progression and temporal pattern of headaches. Nausea, vomiting and phonophobia were more frequent in migraine. Triggering of headaches by dietary factors was associated with migraine, whereas there was no difference between the two groups in any of the other headache triggers. Stress, both physical and psychological, were particularly common in both patient groups.
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Hom, Grant L., Brian L. Hom, Barbara Kaplan, and A. David Rothner. "A Single Institution’s Experience of Primary Headache in Children With Celiac Disease." Journal of Child Neurology 35, no. 1 (September 25, 2019): 37–41. http://dx.doi.org/10.1177/0883073819873751.

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Background: Few studies exist examining the frequency of primary headache in children with celiac disease and the impact of a gluten-free diet on primary headache symptomology. This study explores characteristics and frequency of headaches in children with celiac disease and response to gluten-free diet at a single institution. Methods: Medical records were reviewed for children with celiac disease confirmed by the presence of elevated tissue transglutaminase IgA levels and histologic changes consistent with the diagnosis of celiac disease on small bowel biopsy. Eligible participants were contacted via letter for participation in a phone survey regarding headaches. Phone interviews were conducted 2 weeks after notification and lasted approximately 10 minutes. Headaches were classified according to ICHD-3 criteria. Results: 247 eligible patients or their families were contacted. A total of 132 (53.44%) agreed to participate. One participant was excluded due to insufficient information provided. Overall, 51 of 131 participants had recurrent headache defined as at least 1 episode per month (39%, 95% confidence interval [CI]: 31%-47%) and 33 had migraine with or without aura (25%, 95% CI: 18%-33%). Twenty-eight had frequent tension-type headache (22%, 95% CI: 15%-29%). Thirty-two participants noted headaches before a confirmed diagnosis of celiac disease. Twenty-two of 32 participants (68.75%) noticed decreased headache frequency or intensity, or both, after starting the gluten-free diet. Conclusion: This study suggests that at least one-third of children and adolescents with celiac disease have recurrent headaches at the time of diagnosis. A gluten-free diet led to improved headache symptomology in a significant number of these patients.
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Molina, Omar Franklin, Marcus Geraldo Peixoto, Nayene Leocádia Manzutti Eid, Raphael Navarro Aquilino, and Rise Consolação Iuata Costa Rank. "Headache and Bruxing Behavior Types in Craniomandibular Disorders (Cmds) Patients." Revista Neurociências 19, no. 3 (March 31, 2001): 449–57. http://dx.doi.org/10.34024/rnc.2011.v19.8345.

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Objective. Assess headache and bruxism in Craniomandibular Disorders (CMDs) and non CMDs patients. Method. Clinical examination, questionnaires, headache criteria, severity of bruxism. Results. The prevalence of headache was 68.3% in the CMDs group and 51.4% in the non-CMDs group (p<0.04).Tension type (TTH)=52.8% and combination headaches=25.2% predominated in CMDs. Migraine was more prevalent in Non-CMDs (21.1%) than in CMDs subjects (11.4%). Severe bruxism predominated in the headache/CMDs group=35% as compared to the non-headache/ CMDs group=21%, (p=0.08). We found a frequency of 29.3% extreme bruxism in the headache group and 7% in the non-headache group (p><0.0005). The frequencies of mild/moderate bruxism were about 28% in the TTH, 44.8% in the “other headaches” and 72% in the non-headache/CMDs groups. The frequencies of severe/extreme bruxism were 72.3% in the TTH, 55.2% in the “Other headaches”, and 28% in the non- headache/CMDs groups(p=0.0001). Conclusion. Headache, TTH and combination headache were common in the CMDs group. Severe and extreme bruxism were more prevalent in the headache /CMDs group than in the “other headaches” and in the non/headache CMDs groups. Severe and extreme bruxism were more frequent in the TTH/CMDs group.>
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Silva-Júnior, Ariovaldo Alberto da, Bruno Engler Faleiros, Tales Michel dos Santos, Rodrigo Santiago Gómez, and Antônio Lúcio Teixeira. "Relative frequency of headache types: a longitudinal study in the tertiary care." Arquivos de Neuro-Psiquiatria 68, no. 6 (December 2010): 878–81. http://dx.doi.org/10.1590/s0004-282x2010000600009.

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In order to properly assess patients with primary headache, one needs to follow the cases up longitudinally. In Brazil, there were no studies using this methodology published after the publication of the latest issue of the International Classification of Headaches in 2004 - ICHD-2. This is especially important when we consider that it was only after such publication that we had the criteria used to classify some types of headaches which evolve with daily, or almost daily, spells, and which are very common in tertiary health care centers. OBJECTIVE: To assess the frequency of headache types in a tertiary health care center, in a longitudinal fashion. METHOD: We assessed 95 consecutive patients. These patients were diagnosed and classified according to the ICDH-2. The subjects were followed up for 18 months, they were treated and reassessed. RESULTS: Most of the individuals had more than one type of headache. Among those with episodic migraine in 2007, 6 developed chronic migraine in 2008, producing an incidence rate of 7.2%. Among those with chronic migraine in 2007, 9 remitted, producing a remission rate of 75%. In 2007, 24 individuals abused analgesic agents and 17 no longer showed abuse criteria in 2008 - when 7 new cases were found. CONCLUSION: The diagnosis of migraine remained stable. On the other hand, treatment brought about a reduction in the frequency of headaches caused by excessive use of analgesic, although the frequency of daily chronic headache was almost unaltered.
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Suzuki, Keisuke, Yasuyuki Okuma, Tomoyuki Uchiyama, Masayuki Miyamoto, Ryuji Sakakibara, Yasushi Shimo, Nobutaka Hattori, et al. "The prevalence, course and clinical correlates of migraine in Parkinson’s disease: A multicentre case-controlled study." Cephalalgia 38, no. 9 (October 26, 2017): 1535–44. http://dx.doi.org/10.1177/0333102417739302.

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Background Previous studies have reported a lower migraine prevalence in Parkinson’s disease (PD) patients and improvements in migraine headaches after PD onset, but the clinical association of migraines with PD is unclear. Methods We analysed headache and migraine prevalence and clinical correlates in 436 PD patients (mean age, 69.3 ± 7.8 years) and 401 age- and sex-matched controls (mean age, 69.2 ± 8.6 years) in a case-controlled, multicentre study. Migraines were diagnosed by a questionnaire developed according to the International Classification of Headache Disorders, second edition. We evaluated changes in headache intensity, frequency and severity over several years around the onset of PD among PD patients with headaches or migraines, and over the past several years among control subjects with headaches or migraines. Results PD patients had lower lifetime (9.6% vs. 18.0%) and 1-year (6.7% vs. 11.0%) migraine prevalences than controls. However, lifetime (38.5% vs. 38.9%) and 1-year (26.1% vs. 26.2%) headache prevalence did not differ between PD patients and controls. After adjusting for gender, timing of the evaluation of headache changes, and recall period, PD patients with headaches or migraines exhibited a pronounced reduction in the intensity, frequency and overall severity of their headaches and migraines after the onset of PD compared with controls with headaches or migraines. PD patients with migraines exhibited a higher rate of depression and higher Pittsburgh Sleep Quality Index and PD sleep scale-2 scores than those without headaches. Conclusion While overall headache and migraine severity reduced after PD onset, the presence of migraines was associated with sleep disturbances and depression in PD patients.
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Mitsikostas, DD, and AM Thomas. "Comorbidity of Headache and Depressive Disorders." Cephalalgia 19, no. 4 (May 1999): 211–17. http://dx.doi.org/10.1046/j.1468-2982.1999.019004211.x.

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The goal of the present study was to investigate the clinical profile of patients with primary headache syndromes who also suffer from mood disorders. Four-hundred-and-seventy headache outpatients (170M, 300F) and 150 age- and sex-matched healthy subjects were screened using a specific questionnaire that included the Hamilton rating scales for anxiety and depression. The average scores of the Hamilton rating scales for anxiety and depression were significantly higher in headache sufferers (17.4 and 14.2, respectively) than in healthy people (6.8 and 5.7, respectively). The frequency of headache attacks, the history of headaches, and gender (women more than men) were correlated with the score of the Hamilton rating scale for both anxiety and depression. Sixteen headache patients (3.4%) achieved the DSM-IV criteria for major depression or dysthymia versus one among headache-free subjects (0.6%; OR 5.2). Patients suffering from drug-overuse and migraine with aura showed the higher odds ratios (35 and 17, respectively). These results suggest that those headache patients with long history and high frequency of headaches, or patients suffering from migraine with aura and drug-overuse might benefit from psychiatric evaluation.
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Jull, G., C. Barrett, R. Magee, and P. Ho. "Further Clinical Clarification of the Muscle Dysfunction in Cervical Headache." Cephalalgia 19, no. 3 (April 1999): 179–85. http://dx.doi.org/10.1046/j.1468-2982.1999.1903179.x.

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The Headache Classification Committee of the International Headache Society listed impairments in cervical muscle function as criteria for headaches of cervical spine origin. Fifteen subjects with cervical headache and 15 controls were tested for the frequency of abnormal responses to passive stretching and abnormal muscle contraction. A new test of cranio-cervical flexion was used to assess the contraction of the deep neck flexors. Results indicated a trend towards a higher frequency of abnormal response to passive stretching of the muscles examined in the cervical headache group but only the upper trapezius proved significantly different to the control group. Deep neck flexor muscle contraction was significantly inferior in the cervical headache group. From the perspective of physical characterization of cervical headache, it appears mat response from passive stretch of muscle may not be a strong criterion for cervical headache but deep neck flexor performance may have potential to identify musculoskeletal involvement in headache. The finding may also provide positive directions for conservative treatment of cervical headache.
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Fofi, Luisa, Valerio Orlandi, Nicola Vanacore, Maria C. Mizzoni, Alba Rosa, Cinzia Aurilia, Gabriella Egeo, Pietro Casella, and Piero Barbanti. "Headache in chronic cocaine users: A cross-sectional study." Cephalalgia 34, no. 9 (February 5, 2014): 671–78. http://dx.doi.org/10.1177/0333102414520764.

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Background Headache is one of the most common symptoms after cocaine use. Methods We investigated headache frequency and characteristics and the correlation between headache and acute cocaine intake in a cross-sectional study in a consecutive series of chronic cocaine users. Results Participation rate was 94.1%. Of the 80 subjects enrolled, 72 (90%) reported current headaches, in most cases migraine or probable migraine without aura. Of these 72, 29 (40.3%) had a headache history, whereas 43 (59.7%) reported de novo headache after beginning to use cocaine. After acute cocaine use, a large percentage of users reported headache attacks: 86.2% of previous headache sufferers (migraine or probable migraine without aura in all cases) and 93% of de novo headache sufferers (migraine/probable migraine without aura = 35; episodic tension-type headache = three patients; cocaine-induced headache= two patients). Most subjects reported that when they used cocaine headaches worsened. Conclusion Chronic cocaine use frequently seems to worsen or induce headache with migraine or migraine-like characteristics, probably owing to a serotoninergic and dopaminergic system impairment. In headache sufferers, especially those with migraine headaches, clinicians should enquire into possible cocaine use.
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Aguila, Maria-Eliza R., Trudy Rebbeck, Alun Pope, Karl Ng, and Andrew M. Leaver. "Six-month clinical course and factors associated with non-improvement in migraine and non-migraine headaches." Cephalalgia 38, no. 10 (December 3, 2017): 1672–86. http://dx.doi.org/10.1177/0333102417744360.

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Background Evidence on the medium-term clinical course of recurrent headaches is scarce. This study explored the six-month course and factors associated with non-improvement in migraine compared with tension-type headache and cervicogenic headache. Methods In this longitudinal cohort study, the six-month course of headaches was prospectively examined in participants (n = 37 with migraine; n = 42 with tension-type or cervicogenic headache). Participants underwent physical examination for cervical musculoskeletal impairments at baseline. Participants also completed questionnaires on pain, disability and other self-report measures at baseline and follow-up, and kept an electronic diary for 6 months. Course of headaches was examined using mixed within-between analyses of variance and Markov chain modeling. Multiple factors were evaluated as possible factors associated with non-improvement using regression analysis. Results Headache frequency, intensity, and activity interference in migraine and non-migraine headaches were generally stable over 6 months but showed month-to-month variations. Day-to-day variations were more volatile in the migraine than the non-migraine group, with the highest probability of transitioning from any headache state to no headache (probability = 0.82–0.85). The odds of non-improvement in disability was nearly six times higher with cervical joint dysfunction (odds ratio [95% CI] = 5.58 [1.14–27.42]). Conclusions Headache frequency, intensity, and activity interference change over 6 months, with day-to-day variation being more volatile in migraine than non-migraine headaches. Cervical joint dysfunction appears to be associated with non-improvement for disability in 6 months. These results may contribute to strategies for educating patients to help align their expectations with the nature of their headaches.
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Jesus, Alan Chester Feitosa de, Hélio Araújo Oliveira, Marcelo Oliveira Ribeiro Paixão, Thalyta Porto Fraga, Felipe José N. Barreto, and Marcelo Moraes Valença. "Clinical description of hemodialysis headache in end-stage renal disease patients." Arquivos de Neuro-Psiquiatria 67, no. 4 (December 2009): 978–81. http://dx.doi.org/10.1590/s0004-282x2009000600003.

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BACKGROUND: Hemodialysis (HD)-related headaches are a common complaint of patients undergoing this procedure. OBJECTIVE: To determine the frequency and clinical characteristics of headache in patients undergoing HD and to discuss their diagnostic criteria. METHOD: The present study assessed, in a prospective manner, a series of patients consulting at a HD center in Aracaju, Sergipe, Brazil, from November 2007 to January 2008. Only patients with HD-related headaches without previous history of primary headache were diagnosed as isolated HD headache (HDH). RESULTS: Headache was reported by 76.1% of the patients studied. Prior to beginning dialysis, 47.9% had migraine without aura, 6.7% migraine with aura, 0.6% hemiplegic migraine, 5% episodic tension-type headache, and 2.5% migraine and tension-type headache. HDH was diagnosed in 6.7% of the patients, the most prevalent features being diffuse or temporal region location, bilateral headache, throbbing nature, and moderate severity. Seven patients with headaches between the sessions were not classified. CONCLUSION: While the pathophysiology of HDH is unknown, to diagnose patients with HDH or other possible HD-related headaches remains a challenge.
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Gesztelyi, G., and D. Bereczki. "Disability is the Major Determinant of the Severity of Depressive Symptoms in Primary Headaches but not in Low Back Pain." Cephalalgia 25, no. 8 (August 2005): 598–604. http://dx.doi.org/10.1111/j.1468-2982.2005.00937.x.

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Pain syndromes are often associated with depression. In a prospective study we analysed if determinants of depression differ among patients with different primary headaches and between headaches and non-headache pain. During a 2-year period between 1 February 2002 and 31 January 2004, 635 subjects (migraine n = 231; tension-type headache n = 176; cluster headache n = 11; patients with low back pain n = 103; and healthy subjects n = 114) seen by two neurologists filled in a questionnaire on pain characteristics, the MIDAS questionnaire and the Beck Depression Inventory. A multivariate general regression model was used to identify independent predictors of the severity of depressive symptoms. Pain was most frequent in chronic tension-type headache and most intense in the cluster subgroup (P < 0.001, Kruskal-Wallis ANOVA). In univariate tests gender, age, pain frequency, pain intensity and disability were all significantly associated with the severity of depressive symptoms. In the multivariate model disability was the most important independent determinant of the severity of depressive symptoms in the pooled headache group as well as in the migraine and tension-type headache subgroups. In contrast to patients with headache, pain frequency and pain intensity were the significant independent predictors of the severity of depressive symptoms in patients with low back pain. In a multivariate model, after controlling for other factors, determinants of the severity of depressive symptoms were different in headache and non-headache pain subjects, suggesting a different mechanism for developing depression in primary headaches and in other pain syndromes.
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Kristoffersen, Espen Saxhaug, Knut Stavem, Christofer Lundqvist, and Michael Bjørn Russell. "Excessive daytime sleepiness in chronic migraine and chronic tension-type headache from the general population." Cephalalgia 38, no. 5 (July 10, 2017): 993–97. http://dx.doi.org/10.1177/0333102417721133.

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Introduction A relationship between headache and excessive daytime sleepiness (EDS) has been suggested. This study investigated this association in relation to people with chronic migraine or chronic tension-type headaches. Methods A total of 30,000 persons aged 30–44 from the general population were screened for chronic headache. Those eligible were interviewed by a headache specialist. EDS was defined as Epworth sleepiness scale score >10. Logistic regression models were used. Results Among the 323 eligible participants, 21.1% had EDS. In multivariable logistic regression analysis, the odds ratios (OR) of EDS were not significantly different in people with CM and CTTH. However, high headache frequency was associated with EDS (OR 2.03 (95% CI 1.11–3.73, p = 0.022)) for those with ≥ 80 compared to < 80 headache days/3 months, after adjustment for type of headache, age, and gender. Conclusions Increased EDS was associated with higher headache frequency, but not with specific headache diagnoses.
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Dodick, DW, AC Mosek, and JK Campbell. "The Hypnic (“Alarm Clock”) Headache Syndrome." Cephalalgia 18, no. 3 (April 1998): 152–56. http://dx.doi.org/10.1046/j.1468-2982.1998.1803152.x.

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Hypnic headache syndrome is a rare, sleep-related, benign headache disorder. We report 19 new cases (84% females) with follow-up data. The mean age at headache onset was 60.5 ± 9 years (range 40–73 years). Headache awakened the patients from the night's sleep at a consistent time, usually between 1.00 and 3.00 a.m. (63%); three patients (16%) reported that identical headaches could occur also during daytime naps. Headache frequency was high, occurring more than 4 nights/week in 68% of the patients. Headache resolution occurred within 2 h in 68% of patients. Neurologic examination, laboratory studies, and brain imaging were unrevealing at the time of diagnosis. Headache severity largely remains unchanged or attenuates over time, but frequency may vary in either direction. Only one patient had spontaneous relief from headache. Four patients (24%) achieved permanent suppression of headache with medication, and two were able to abort individual headache attacks. Caffeine in a tablet or beverage was helpful in four patients. Lithium carbonate therapy caused side effects requiring cessation of treatment in four patients.
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Albuquerque, Regina Pires de, Adriana Barbosa Santos, Waldir Antônio Tognola, and Marco Antônio Arruda. "An epidemiologic study of headaches in brazilian schoolchildren with a focus on pain frequency." Arquivos de Neuro-Psiquiatria 67, no. 3b (September 2009): 798–803. http://dx.doi.org/10.1590/s0004-282x2009000500003.

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The purpose of this study was to assess the prevalence and frequency of the headaches in Brazilian schoolchildren. A cross-sectional study was conducted between March and November 2004 in São José do Rio Preto, São Paulo State, Brazil. A sample of 5,232 children from elementary schools was selected using proportional stratified sampling method. To collect data, a questionnaire was handed out in the schools to the schoolchildren to be answered by parents or guardians. From the total answers received, 84.2% reported headache complaints during the last year. There were significant complaint differences between males and females. Females were reported as having more frequent headaches than males with daily ones occurring twice as many times. A greater headache frequency was also reported for increasing age. The study has shown that headache prevalence was high, with a predominantly higher frequency (monthly, weekly and daily) with girls and older age groups.
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Leone, M., AP Cecchini, E. Mea, V. Tulio, and G. Bussone. "Epidemiology of Fixed Unilateral Headaches." Cephalalgia 28, no. 1_suppl (July 2008): 8–11. http://dx.doi.org/10.1111/j.1468-2982.2008.01607.x.

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A fixed location unilateral headache suggests involvement of a precise nervous structure, and neuroimaging investigations are essential to seek to identify it. Nevertheless, side-locked primary headaches also occur, although they are rare. Side-locked primary headaches are more frequently found in the group of the short-lasting (≤ 4 hours) headaches but long-lasting headache forms may also present with the pain always on the same side, including migraine, tension-type headache, new daily persistent headache and cervicogenic headache. Future studies should address the issue whether patients with side-locked headache form differ from those with non-side-locked form both in terms of natural history and biological markers. Among 63 consecutive chronic cluster headache patients seen by us from 1999 to 2007, 32 (51±) had side shift. We also found that the duration of the chronic condition was significantly longer in those with side shift than those without. The high frequency of side shift in chronic cluster headache should be considered when proposing surgical treatment for severe intractable forms of the disease.
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Zaric, N., N. Milovanovic-Kovacevic, M. Savic, and M. Delic-Miskovic. "Frequency of headache in stroke." Journal of the Neurological Sciences 357 (October 2015): e170. http://dx.doi.org/10.1016/j.jns.2015.08.582.

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Laurell, K., B. Larsson, and O. Eeg-Olofsson. "Headache in Schoolchildren: Agreement Between Different Sources of Information." Cephalalgia 23, no. 6 (July 2003): 420–28. http://dx.doi.org/10.1046/j.1468-2982.2003.00540.x.

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The level of agreement between different sources of information, i.e. questionnaires, interviews and diaries, was evaluated in a sample of 129 schoolchildren, 69 girls and 60 boys, ranging in age from 7 to 17 years. Headache diagnoses and headache features showed high agreement between questionnaires and subsequent interviews. The concordance between questionnaires and interviews for headache diagnoses increased, and the number of unclassified headaches decreased, when the International Headache Society (IHS) duration criterion was excluded. When comparing headache frequency reported in questionnaires and interviews with diary recordings, the agreement was low and the frequency higher in the diaries. Overall, the agreement between questionnaires, interviews and diaries was not related to age or gender. The questionnaire may serve as a valid source of information in studies of headache in schoolchildren. Prospective recordings in diaries provide additional information, in particular of low-intensity headache. In children, the IHS duration criterion should be modified or excluded.
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Rasmussen, BK. "Epidemiology of Headache." Cephalalgia 21, no. 7 (September 2001): 774–77. http://dx.doi.org/10.1177/033310240102100708.

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Headache disorders constitute a public-health problem of enormous proportions, with an impact on both the individual sufferer and society. Epidemiological knowledge is required to quantitate the significance of these disorders. The effects on individuals can be assessed by examining prevalence, distribution, attack frequency and duration, and headache-related disability. The socio-economic burden includes both direct costs associated with health care utilization and costs associated with missed work due to sickness absence or reduced efficiency. The individual and socio-economic burden of headaches is substantial. Headache disorders deserve more attention, especially concerning strategies leading to adequate primary prevention, diagnosis and treatment.
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Jull, GA, and WR Stanton. "Predictors of Responsiveness to Physiotherapy Management of Cervicogenic Headache." Cephalalgia 25, no. 2 (February 2005): 101–8. http://dx.doi.org/10.1111/j.1468-2982.2004.00811.x.

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A recent randomized controlled trial tested the effectiveness of therapeutic exercise and manipulative therapy on 200 subjects with cervicogenic headache. Although treatments were efficacious, 25% of patients did not achieve a clinically acceptable outcome – 50% reduction in headache frequency. This study aimed to identify predictors from variables in subjects' demographics and headache history which might identify those who did or did not achieve a 50-79% or 80-100% reduction in headache immediately after the active treatments and 12 months postintervention. The results revealed no consistent pattern of predictors, although the absence of light-headedness indicated higher odds of achieving either a 50-79% [odds ratio (OR) = 5.45) or 80-100% (OR = 5.7) reduction in headache frequency in the long term. Headaches of at least moderate intensity, the patient's age and chronicity of headache did not mitigate against a successful outcome from physiotherapy intervention.
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Pryse-Phillips, William, Helen Findlay, Peter Tugwell, John Edmeads, T. J. Murray, and R. F. Nelson. "A Canadian Population Survey on the Clinical, Epidemiologic and Societal Impact of Migraine and Tension-Type Headache." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 19, no. 3 (August 1992): 333–39. http://dx.doi.org/10.1017/s0317167100041950.

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ABSTRACT:Trained telephone interviewers contacted 1,573 adults across Canada about the nature and frequency of headaches suffered by them or by others in their households. Using a table of pain symptoms and other characteristics abstracted from the International Headache Society (IHS) classification, the headaches were assigned to migraine headache, tension-type headache or other diagnostic groups. Of the households sampled, 59% had at least one headache sufferer in residence. The proportion of headache sufferers with migraine was 14%; with tension-type, 36%; and with both, 14%. Migraine headache caused more disability than tension-type headache, with nearly 20% of migraine sufferers taking time off work and disability lasting for a mean of 1 day. It is concluded that the current prevalences of migraine and tension-type headache in Canada fall around the mean of previous studies, that the IHS criteria can form a basis for diagnostic classification and that the functional impact of migraine has been seriously underestimated in the past.
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Soee, Ann-Britt L., Liselotte Skov, Lene Theil Skovgaard, and Lise L. Thomsen. "Headache in children: Effectiveness of multidisciplinary treatment in a tertiary paediatric headache clinic." Cephalalgia 33, no. 15 (July 11, 2013): 1218–28. http://dx.doi.org/10.1177/0333102413490349.

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Aim The aim of this article is to evaluate the effectiveness of a specific multidisciplinary treatment programme for children with headache and to describe the concept and settings of the Children’s Headache Clinic in Denmark. Method All new patients were included and evaluations were conducted after six and 12 months. Pharmacological and non-pharmacological treatments were offered by a team of specialists (physicians, headache nurses, a physiotherapist and a psychologist). Patients The subjects comprised 169 children (mean age 11.7 (range 4–17), 91 females, 78 males), 39% of whom suffered from chronic headache (≥15 days/month). All children were diagnosed according to the International Classification of Headache Disorders, second edition; 20% had migraine, 34% tension-type headache, 27% mixed headache, 4% medication-overuse headache, and 15% were diagnosed with other types of headaches. Results Fifty per cent of the children had an improvement in headache frequency above 50% at six months. By the use of repeated measurement analysis, we found a significant decrease in headache frequency in all of the six headache groups, whereas the increase in quality of life (PedsQL™ 4.0) was significant for the group as a whole. Conclusion Though preliminary, the results show a good outcome for multidisciplinary treatment programmes for children who suffer from frequent or chronic headache.
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Rodríguez-Almagro, Daniel, Alexander Achalandabaso-Ochoa, Francisco Javier Molina-Ortega, Esteban Obrero-Gaitán, Alfonso Javier Ibáñez-Vera, and Rafael Lomas-Vega. "Neck Pain- and Unsteadiness-Inducing Activities and their Relationship to the Presence, Intensity, Frequency, and Disability of Headaches." Brain Sciences 10, no. 7 (July 3, 2020): 425. http://dx.doi.org/10.3390/brainsci10070425.

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(1) Background: Headache is a significant public health problem. Despite the association between headache and neck pain, little is known about the relationships among specific activities that generate neck pain and headache. The aim of this study was to identify the specific activities that result in neck pain and unsteadiness, and determine how they are linked to headache in university students. (2) Methods: One hundred and six patients with physician-diagnosed headache and 92 healthy university students completed surveys assessing demographics; the presence, frequency, intensity, and disability of headaches; and activities generating neck pain and unsteadiness. (3) Results: The presence of headache was related to female gender (p = 0.001), neck pain when reading or watching television (p = 0.024), and unsteadiness when moving the head (p = 0.005). Headache-related disability was associated with intensity of neck pain (p < 0.001), neck pain when reading or watching television (p = 0.033), and stumbling (p < 0.001). Headache frequency was related to smoking (p = 0.004), the duration of neck pain-associated symptoms (p = 0.047), and neck pain when driving (p = 0.039). Intensity of headache was associated with female gender (p = 0.002), smoking (p = 0.013), and neck pain-related sleep alterations (p = 0.024). (4) Conclusions: Female gender, smoking, neck pain, and unsteadiness when moving the head are factors related to headache in university students.
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Arruda, Marco Antônio, Renato Arruda, Vincenzo Guidetti, and Marcelo Eduardo Bigal. "ADHD Is Comorbid to Migraine in Childhood: A Population-Based Study." Journal of Attention Disorders 24, no. 7 (June 6, 2017): 990–1001. http://dx.doi.org/10.1177/1087054717710767.

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Objective: Recurrent headaches and ADHD are prevalent in the pediatric population. Herein, we assess if ADHD is comorbid to headaches overall, to headache subtypes (e.g., migraine), and to headache frequency. Method: Informed consent and analyzable data were obtained for 5,671 children aged 5 to 12 years (65.9% of the target sample). Parents and teachers were interviewed using validated questionnaires based on the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5). Relative risks were modeled using univariate and multivariate analyses. Results: As contrasted to nonheadache controls, the prevalence of ADHD was significantly higher in children with migraine ( p < .001) but not in those with tension-type headaches. In children with migraine, risk of ADHD increased as a function of headache frequency ( p < .05). Conclusion: Migraine and frequent migraine are comorbid to ADHD. Future studies should focus on the impact of the association on the burden to the children and their families.
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Martin, Geoffrey V., Timothy Houle, Robert Nicholson, Albert Peterlin, and Vincent T. Martin. "Lightning and its association with the frequency of headache in migraineurs: An observational cohort study." Cephalalgia 33, no. 6 (January 24, 2013): 375–83. http://dx.doi.org/10.1177/0333102412474502.

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Aim The aim of this article is to determine if lightning is associated with the frequency of headache in migraineurs. Methods Participants fulfilling diagnostic criteria for International Headache Society-defined migraine were recruited from sites located in Ohio ( n = 23) and Missouri ( n = 67). They recorded headache activity in a daily diary for three to six months. A generalized estimating equations (GEE) logistic regression determined the odds ratio (OR) of headache on lightning days compared to non-lightning days. Other weather factors associated with thunderstorms were also added as covariates to the GEE model to see how they would attenuate the effect of lightning on headache. Results The mean age of the study population was 44 and 91% were female. The OR for headache was 1.31 (95% confidence limits (CL); 1.07, 1.66) during lighting days as compared to non-lightning days. The addition of thunderstorm-associated weather variables as covariates were only able to reduce the OR for headache on lightning days to 1.18 (95% CL; 1.02, 1.37). The probability of having a headache on lightning days was also further increased when the average current of lightning strikes for the day was more negative. Conclusion This study suggests that lightning represents a trigger for headache in migraineurs that cannot be completely explained by other meteorological factors. It is unknown if lightning directly triggers headaches through electromagnetic waves or indirectly through production of bioaerosols (e.g. ozone), induction of fungal spores or other mechanisms. These results should be interpreted cautiously until replicated in a second dataset.
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Krogh, Anne-Berit, Bo Larsson, and Mattias Linde. "Prevalence and disability of headache among Norwegian adolescents: A cross-sectional school-based study." Cephalalgia 35, no. 13 (February 26, 2015): 1181–91. http://dx.doi.org/10.1177/0333102415573512.

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Background Headache is common in adolescents and affects schoolwork and relations with friends and family. In most previous epidemiological surveys, only the most bothersome headache has been documented. The aim was to determine headache prevalence not only taking into account the most bothersome headache, but also to compare characteristics of the most bothersome and less bothersome headaches, and to investigate headache-related disability. Methods A cross-sectional school-based study was conducted in which 493 representative adolescents aged 12–18 years were recruited by stratified cluster sampling and interviewed. Headache diagnosis was made according to the new classification system of the International Headache Society (ICHD-3 beta), and the Pediatric Migraine Disability Assessment (PedMIDAS) was used to evaluate disability. Results The one-year prevalence of any headache type, definite migraine, probable migraine and tension-type headache was 88%, 23%, 13% and 58%, respectively. The point prevalence of any headache was 38%. Nine percent of participants fulfilled criteria for more than one headache diagnosis. The most bothersome headache had a significantly longer duration ( p < 0.001) and higher intensity ( p < 0.001) than the less bothersome headache, but similar frequency ( p = 0.86). Adolescents with headaches lost up to nine days of activity each year, implicating headache as a major health issue. Conclusions Headaches are very common and disabling among adolescents. The full extent of this health problem is better appreciated if inquiry is not limited to the most bothersome subtypes.
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Аrtemenkо, Аda R., Olga A. Shavlovskaya, Vera V. Оsipovа, Gennadiy V. Kovrov, and Rovshan L. Gasanov. "Sleep-related headaches: clinical features and treatment approaches." L.O. Badalyan Neurological Journal 1, no. 1 (April 19, 2020): 35–46. http://dx.doi.org/10.17816/2686-8997-2020-1-01-35-46.

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Headaches occurring during sleep are one of the most common types of night time pain complaints, along with back pain. Sleep-related headaches can be a manifestation of both primary headaches (migraine, cluster headache, chronic paroxysmal hemicrania, hypnic headache) and secondary headaches associated with somatic pathology (anemia, hypoxemia), neurological disorders (brain tumors, arteriovenous malformations), psychiatric (depressive, anxiety) and sleep disorders (obstructive sleep apnea). The relationship between headaches and sleep depends on the patients age, frequency and severity of the headaches, provoking factors (excessive sleep, sleep deprivation, overuse of painkillers), the stage of sleep (REM sleep or slow-wave sleep) and possible genetic predisposition (hemiplegic migraine). The connections between sleep and headaches are complex and interrelated. Sleep can both provoke and relieve headaches. On the other hand, headaches can cause sleep disorders, which are typical for a severe type of cephalgia with the development of chronic daily headache syndrome, medication overuse, and psychiatric comorbidity. General anatomical structures, neurochemical and neurophysiological mechanisms involved in sleep and headache regulation are assumed. According to polysomnography data, objective changes in the structure of night sleep were detected in patients with a sleep-related headache: a reduction in the sleep duration and a decrease in the slow-wave sleep representation. Most nighttime headache attacks are linked with the REM sleep phase. Management of patients with sleep-related headaches should include the diagnosis and treatment of both headache and sleep disorder, which will significantly improve the results of treatment or even cure headaches in some cases.
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Slater, S., MJ Crawford, MA Kabbouche, SL LeCates, S. Cherney, P. Vaughan, A. Segers, et al. "Effects of Gender and Age on Paediatric Headache." Cephalalgia 29, no. 9 (September 2009): 969–73. http://dx.doi.org/10.1111/j.1468-2982.2008.01827.x.

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The aim of this study was to evaluate the impact of gender and age on headache characteristics and disability. Headache characteristics were assessed at an initial visit to a paediatric specialty care centre and five follow-up visits. A total number of 4121 patients were evaluated. Fifty-eight per cent of the sample was female. Boys were younger at their first headache and initial visit. They more frequently described headache pain as squeezing and location as top of the head. Girls reported more frequent and longer headaches. Girls more often described headache pain as sharp and location as back of the head. Age accounted for more variance than gender in headache severity, duration, frequency and disability. Gender differences exist in headache characteristics. Age is also an important factor in the variability in characteristics and disability. Longitudinal studies are needed to describe further the natural history of headaches in childhood and compare outcome between genders.
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Nicoletti, A., F. Patti, S. Lo Fermo, A. Liberto, A. Castiglione, P. Laisa, A. Garifoli, et al. "Headache and Multiple Sclerosis: A Population-Based Case-Control Study in Catania, Sicily." Cephalalgia 28, no. 11 (November 2008): 1163–69. http://dx.doi.org/10.1111/j.1468-2982.2008.01662.x.

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We carried out a population-based case-control study to evaluate the association between multiple sclerosis (MS) and headache. We had previously determined the incidence of MS during 1990-1999 in Catania, Sicily, identifying 155 incident MS patients; these subjects underwent a telephone interview using a standardized questionnaire for headache. Diagnosis and classification of headaches were made according to International Headache Society criteria (1988). A control group was selected from the general population through random digit dialling. One hundred and one (65.2±) MS patients, of the 155 identified, and 101 controls were screened for headaches. Fifty-eight (57.4±) MS patients and 38 (37.2±) controls fulfilled the diagnostic criteria of headache. A significant association between MS and headache was found with an adjusted odds ratio, estimated by logistic regression, of 2.18 (95± confidence interval 1.27, 3.93). Frequency of headaches in our MS population is higher than in the general population, supporting the hypothesis of a possible association between these two conditions.
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Karacan Gölen, Meltem, and Dilek Yilmaz Okuyan. "Covid-19 and headache characteristics." Neurology Asia 26, no. 3 (September 2021): 527–34. http://dx.doi.org/10.54029/2021jkf.

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Background & Objective: Studies have shown that the most common neurologic symptom in patients with COVID-19 is headache, which may even be the first and only symptom. This study aimed to determine headache characteristics such as frequency, duration and localization, as well as the relationship of systemic inflammation with headaches in patients with COVID-19. Methods: A total of 202 patients hospitalized for COVID-19, consisting of 101 patients with headaches and 101 patients with no headache, were included in the study. Demographic characteristics, symptoms, clinical findings, and laboratory results were evaluated. In the group with headaches, visual analog scale (VAS) scores, duration, severity, and localization of pain were recorded. Results: One hundred nineteen (58.9%) of the patients had no headache in their previous medical history, whereas 21.3% (43/202) had a migraine history. Most of the patients with headache experienced short-term attacks of moderate-severity headaches (47.1%) that were pressing in nature (59%), and generalized (32.4%). We divided our patients into two groups according to pain severity: one of patients with mild-to-moderate headache and one of those with severe headache.. Pain characteristics were compared between the groups, and it was observed that the pain duration was longer in the group with severe pain (p<0.001). When the groups with and without headaches were compared, no significant differences were found between the groups regarding inflammatory markers such as lymphocyte count, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer levels. Conclusion: The headache in our patients with COVID-19 was mostly new-onset, of moderate severity, compressive in nature, and generalized. Inflammatory markers were unrelated to the presence and severity of the headaches.
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Melvin, Jr, Eugene A. "Using Peripheral Stimulation to Reduce the Pain of C2-Mediated Occipital Headaches: A Preliminary Report." Pain Physician 3;10, no. 5;3 (May 14, 2007): 453–60. http://dx.doi.org/10.36076/ppj.2007/10/453.

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Background: Peripheral nerve stimulation (PNS) is an accepted treatment for neuropathic pain. Recent studies have focused on its potential for relieving headache pain. Objectives: To investigate the effectiveness of PNS in reducing occipital headache pain. Design: A prospective, 12-week pilot study involving 11 patients evaluated before and after implantation of PNS systems to treat C2-mediated occipital headaches. Methods: Prior to and at 4 and 12 weeks after implantation, patients completed the Short-Form McGill Pain Questionnaire (SF-MPQ), Visual Analog Scale (VAS), and Present Pain Index (PPI). Patients also answered questionnaires and kept diaries to record stimulator use, medication consumption, and numbers of headaches. Results: A comparison of pre- and post-implantation evaluations showed statistically significant declines in scores on the SF-MPQ (64%; p = 0.0013), VAS (67%; p < 0.0001), and PPI (68%; p = 0.0009). Most patients (91% and 64% respectively) reported reductions in medication use and numbers of headaches. Patients also reported a reduction in headache symptoms and the impact of headaches on activities. Two adverse events were encountered, one due to a loose connection and, the other caused by lead migration. Conclusions: PNS reduced headache pain, headache frequency and medication use. Key words: peripheral nerve stimulation, PNS, peripheral nerve, occipital headache, headache pain
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