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Relevant bibliographies by topics / Head and neck tumour

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Academic literature on the topic 'Head and neck tumour'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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Journal articles on the topic "Head and neck tumour"

1

GAZE, M. N., and JANET A. WILSON. "REVIEW Head and neck tumour immunology." Clinical Otolaryngology 13, no. 6 (December 1988): 495–99. http://dx.doi.org/10.1111/j.1365-2273.1988.tb00324.x.

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Silva, Andreia, Patrícia Caixeirinho, Miguel Vilares, Carina Semedo, Mariluz Martins, Carlos Zagalo, and Diogo Casal. "Retrospective Study of 114 Free Flaps for Head and Neck Oncological Reconstruction in a Portuguese Tertiary Cancer Center." Acta Médica Portuguesa 35, no. 3 (March 2, 2022): 192. http://dx.doi.org/10.20344/amp.13734.

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Introduction: The Portuguese experience in microsurgical reconstruction of the head and neck after oncological surgery is scantly described. The primary aim of this study was to characterize the use of microvascular reconstruction after head and neck tumor resection in a Portuguese tertiary oncological centerMaterial and Methods: The authors retrospectively evaluated 114 microvascular free flap procedures performed for head and neck reconstruction after oncological resection in a department of Head and Neck Surgery of a Portuguese tertiary oncological center. Patients were operated on from January 2012 to May 2018. Data on patient demographic features, tumour characteristics, perioperative complications, postoperative aesthetic and functional results, survival time and time to recurrence were extracted.Results: Most tumours mandating microsurgical reconstruction were mucosal squamous cell carcinomas (85%) and were located in the oral region (95.6%). Around 45% of the patients had a T4a tumour and 30% a T2 tumour. Cervical metastases were present in 45.6% of the cases. The radial forearm flap and the fibular flap were the most commonly used microsurgical reconstructive options (58% and 41%, respectively). More than 80% of patients had no post-operative complications. Partial necrosis of the flap occurred in 6.1% of patients, while total flap necrosis occurred in 3.5% of cases. Aesthetic and functional results were considered at least satisfactory in all patients in which the flaps survived.Conclusion: Microvascular reconstruction seems like a reliable treatment option in head and neck oncological surgery at our institution.

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Aremu, Shuaib K., Kayode Rasaq Adewoye, and Tayo Ibrahim. "Immunotherapy for head and neck cancers." International Surgery Journal 6, no. 10 (September 26, 2019): 3884. http://dx.doi.org/10.18203/2349-2902.isj20194465.

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Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour which arises from various anatomical areas in the head and neck region. HNSCC has multiple resistance mechanisms through which it evades the immune responses. It is particularly characterized by an immunosuppressive environment which includes the release of immunosuppressive factors, expansion, and expansion of immune cells which have inhibitory activity reduction of tumour immunogenicity. Human papillomavirus positive (HPV+) HNSCC tumours have one of the higher levels of T cells infiltration. Studies which explore this relationship to the prognosis of patients vary, with some showing benefit only with high CD8/Treg ratio as seen with HPV+ diseaseand others showing improved prognosis with a higher number of TIL Treg. High CD8+ TIL seen in HPV + disease has been shown in several studies to confer improved disease-free survival. The most successful vaccination strategy is preventive vaccination for HPV. Investigations using different approaches have been carried out on therapeutic vaccines for HPV-associated HNSCC. Despite immune responses being seen in a number of studies, these vaccines are still not effective for clinical use as of yet.

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Baharudin, A., A. Khairuddin, A. Nizam, and A. R. Samsuddin. "Evaluation of irradiated salivary gland function in patients with head and neck tumours treated with radiotherapy." Journal of Laryngology & Otology 123, no. 1 (May 1, 2008): 108–13. http://dx.doi.org/10.1017/s0022215108002466.

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AbstractIntroduction:Radiotherapy is an important treatment modality for head and neck tumours. One of its major drawbacks is post-treatment salivary gland hypofunction. This study was performed to objectively evaluate the salivary gland function in post-irradiated head and neck tumour patients.Methods:We performed a cross-sectional study of 30 patients with head and neck tumours who had received radiotherapy. Unstimulated and stimulated whole salivary flow rates were assessed in these 30 patients, and compared with those of 30 normal subjects. Unstimulated whole saliva was measured by the draining method, while the spitting method was used to collect stimulated whole saliva.Results:Both unstimulated and stimulated whole salivary flow rates were significantly reduced in the irradiated patients, compared with the normal subjects. This difference was statistically significant (p = 0.0001).Conclusion:Salivary function in post-irradiated head and neck tumour patients (assessed as salivary flow rates) was significantly reduced compared with normal controls, suggesting marked salivary gland hypofunction.

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Ślaska, Brygida, Magdalena Surdyka, Adam Brodzki, Sylwia Nisztuk, Artur Gurgul, Monika Bugno-Poniewierska, Anna Śmiech, Dorota Różańska, and Maciej Orzelski. "Mitochondrial D-loop mutations can be detected in sporadic malignant tumours in dogs." Bulletin of the Veterinary Institute in Pulawy 58, no. 4 (December 1, 2014): 631–37. http://dx.doi.org/10.2478/bvip-2014-0096.

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Abstract The aim of this study was to identify mutations in the D-loop region of mtDNA in head, neck, and limb tumours in dogs, and determination of their relationship with the process of neoplastic transformation. Blood and tumour tissue samples from 19 dogs with diagnosed sporadic malignant tumours were analysed. DNA extraction, amplification, and sequencing of the mtDNA D-loop, and bioinformatic analyses were performed. Five mutations and 19 polymorphisms were observed in 68.42% of all tumours. Polymorphic variants were noted in 42.86% of the head and neck tumours and in 58.33% of the limb tumours. Mutations were observed in 21.05% of dogs. The mutations were found in 28.57% of the head and neck tumours and in 16.66% of the limb tumours. The mutations were identified in 50% of the studied epithelial cancers. In the mesenchymal tumours, no mutations in the D-loop region were observed. Mitochondrial haplotype A17 was found in over 40% cases of limb tumours. No association between the age, breed, sex, type of tumour, and detected polymorphic variants were observed. Different mutational changes in the D-loop sequences of mtDNA identified in the blood and tumour tissues may indicate a relationship between the type of tumour and individual changes in the D-loop nucleotide sequences of mtDNA.

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Eldabe, S. S., and D. M. Ryall. "Anaesthesia for head and neck tumour surgery." Current Anaesthesia & Critical Care 7, no. 1 (February 1996): 9–14. http://dx.doi.org/10.1016/s0953-7112(96)80025-1.

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7

van der Laan, B. F. A. M., G. BARIS, R. Th Gregor, F. J. M. Hilgers, and A. J. M. Balm. "Radiation-induced tumours of the head and neck." Journal of Laryngology & Otology 109, no. 4 (April 1995): 346–49. http://dx.doi.org/10.1017/s0022215100130117.

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AbstractIn order to study the induction of malignancy in normal tissues due to ionizing radiation, we reviewed the files of 2500 patients with a tumour of the head and neck treated at the Netherlands Cancer Institute (Antoni van Leeuwenhoek Ziekenhuis), Amsterdam, from 1977 to 1993. We then checked whether or not these patients had been previously irradiated. Patients with a thyroid carcinoma or skin cancer were excluded from the study, since it is generally known that previous irradiation is a risk factor in these tumours. Eighteen patients were found to have a malignancy within a previously irradiated area (0.70 per cent). The mean interval between radiation and diagnosis of the head and neck tumour was 36.5 years. There were five soft tissue sarcomas, nine squamous cell carcinomas and four salivary gland tumours. Fourteen patients were operated upon whereas four received palliative treatment only. The median survival of the total group was 3.5 years. Particularly. in young patients because of the better cancer therapy and prolonged survival one must be aware of the increased risk of radiation-induced tumours.

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Sim, Sing Yang, and Ma’en Al-Mrayat. "Thyroid Paraganglioma- An Unusual Head and Neck Tumour." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A962. http://dx.doi.org/10.1210/jendso/bvab048.1966.

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Abstract Paragangliomas are neuroendocrine tumour originating from the neural crest-derived paraganglia with majority arising from the head and neck. (1)Thyroid paraganglioma are exceedingly rare neuroendocrine tumours accounting for <0.1% of thyroid malignancy (1) We present a 57 years old gentleman who was referred to ENT surgeon following discovery of a two month history of lump on his left neckIt has not changed in size and not caused any symptoms such as anxiety, sweats, palpitations, dizziness or unexplained headaches. He has a Past medical history of epilepsy following a Road traffic accident 28 years ago leaving him seizure prone. He has no family history of neuroendocrine tumours His ultrasound scan of his thyroid gland showed a 25 x 23 x 15mm lesion lying anteriorly within the left thyroid lobe. There are two highly reflective foci which could represent microcalcification. It was classified as U5 lesion He proceeded with fine needle aspiration which confirmed carcinoma of the left thyroid gland with no clear differentiation between follicular or papillary carcinoma. He undergone a total thyroidectomy and left central level VI lymph node dissection His histology confirmed a thyroid paraganglioma staining strongly positive for neuroendocrine markers (Synaptophysin and chromogranin) while S-100 shows positivity in the sustentacular cells. He was referred for genetic testing which demonstrate no evidence of mutation in FH, SDHAF2, SDHB/C/D, RET, MAX, TMEM127 and VHL gene. He was commenced on levothyroxine replacement at a dose of 150micrograms OD. His urine metanephrines is 178.1pmol/L (0-510), urine normetanephrines 192.9pmol/L (0-1180) and 3-methoxytyramine <75pmol/ L (0-180) (all normal). His MRI neck revealed no synchronous tumour. He continues to be followed up under our endocrine clinic. Conclusion: Due to the rarity of these tumours, their natural history is mostly unknown. Nevertheless, postoperative surveillance should include plasma or urinary metanephrines and ultrasonography. References: 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824793/

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Gustafsson, H., A. Kale, A. Dasu, A. Lund, P. H. Edqvist, and K. Roberg. "EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model." Cell Biochemistry and Biophysics 75, no. 3-4 (July 29, 2017): 299–309. http://dx.doi.org/10.1007/s12013-017-0814-5.

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Abstract Head and neck squamous cell carcinoma (HNSCC) tumours are associated with high mortality despite advances in therapy. The monoclonal antibody cetuximab (Erbitux®) has been approved for the treatment of advanced HNSCC. However, only a subset of HNSC patients receiving cetuximab actually responds to treatment, underlining the need for a means to tailor treatments of individual patients. The aim of the present study was to investigate the effect of cetuximab treatment on tumour growth, on tumour partial oxygen pressure as measured by LiPc electron paramagnetic resonance oximetry and on the expression of proteins involved in tumour growth, metabolism and hypoxia. Two HNSCC cell lines, UT-SCC-2 and UT-SCC-14, were used to generate xenografts on female BALB/c (nu/nu) nude mice. Mice with xenografts were given three injections of intraperitoneal cetuximab or phosphate-buffered saline, and the tumour volume was recorded continuously. After treatment the tumour partial oxygen pressure was measured by LiPc electron paramagnetic resonance oximetry and the expression of epidermal growth factor receptor (EGFR), phosphorylated EGFR, Ki-67, MCT1, MCT4, GLUT1, CAIX and HIF-1α were investigated by immunohistochemistry. In xenografts from both cell lines (UT-SCC-2 and UT-SCC-14) cetuximab had effect on the tumour volume but the effect was more pronounced on UT-SCC-14 xenografts. A higher tumour oxygenation was measured in cetuximab-treated tumours from both cell lines compared to untreated controls. Immunocytochemical staining after cetuximab treatment shows a significantly decreased expression of EGFR, pEGFR, Ki67, CAIX and nuclear HIF-1α in UT-SCC-14 tumours compared to untreated controls. MCT1 and GLUT1 were significantly decreased in tumours from both cell lines but more pronounced in UT-SCC-14 tumours. Taken together, our results show that cetuximab treatment decreases the tumour growth and increases the tumour partial oxygen pressure of HNSCC xenografts. Furthermore we found a potential connection between the partial oxygen pressure of the tumours and the expression of proteins involved in tumour growth, metabolism and hypoxia.

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Pfleiderer, A. G., P. Thomson, and C. M. Milroy. "ENT presentation of Ollier's disease." Journal of Laryngology & Otology 105, no. 2 (February 1991): 148–50. http://dx.doi.org/10.1017/s002221510011521x.

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AbstractCartilaginous tumours occurring in the head and neck are usually regarded and seen as solitary lesions. However, we present an unique case where the cartilaginous tumour in the ENT region was the presenting feature of Ollier's disease (multiple enchondromatosis). It is recommended that further investigations be carried out in patients with cartilaginous tumours presenting in the head and neck to exclude the possible presence of this unusual and interesting syndrome.

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Dissertations / Theses on the topic "Head and neck tumour"

1

Sundelin, Kaarina. "Head and Neck Cancer : Factors Affecting Tumour Growth." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1032s.pdf.

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Murray, Patrick Francis. "Immunomodulation within the head and neck tumour microenvironment." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10124.

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Changes in the immune response have been implicated in the progression of squamous cell carcinoma of the head and neck (HNSCC). Evidence is emerging that processes within the tumour microenvironment can lead to immune modulation and subsequent tumour growth or metastasis. The hypothesis of this thesis is that the HNSCC tumour microenvironment will have increased levels of cytokines that produce an overall negative effect on the cellular cytotoxic immune response against the malignant cells. Specifically, it is hypothesised that a Th-2-like anti-inflammatory response will favour tumour cell progression and be associated with advanced stage HNSCC. This thesis examines the levels of a panel of immune cytokines to investigate whether difference in these levels have an association with the progression of the disease and other standard clinico-pathological factors. A method of protein extraction from tumour tissue and detection of quantitative cytokine levels was developed and optimised. A cohort of 69 patients newly-presenting with HNSCC was recruited prospectively to the study, with a total of 83 samples of primary HNSCC tumour tissue and metastatic nodal tissue being investigated. Increased levels of TGF-β, described as concentration of cytokine/mg total protein extracted, (median 1051 pg/mg vs. 659 pg/mg, p= 0.004) and reduced levels of IL-17 (median 4.2pg/mg vs. median 18.6 pg/mg, p= 0.009), compared with normal tissue from control patients were reported. The HNSCC samples were also found to have higher levels of VEGF in tumour samples (83 pg/mg vs. 27.6 pg/mg, p=0.026) compared with control tissue. No difference was found in the levels of IL-2, IL-10, IL-12, IL-15, or IL-17. When comparing early stage (I-III) to late stage IV HNSCC patients it was found that there were significantly lower levels of the Th1-like IL-12 in the higher stage IV patients (median 50pg/mg vs. 21 pg/mg, p= 0.01), and significantly higher levels of IL-15 in stage IV patients (median 52 pg/mg, vs. 20 pg/mg p= 0.03). In summary, analysis of cytokine levels within the tumour microenvironment of HNSCC may be of prognostic value, and further study of the immune suppressive nature of HNSCC could open potential therapeutic approaches, especially if such data are correlated with other cellular parameters, e.g. T regulatory or CD8+ve T cell levels.

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Kulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.

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Metastasis in head and neck cancer patients is responsible for over 50% of deaths. There are currently no tools to identify patients at risk of developing metastasis. Circulating tumour cells (CTC) represent a transient cancer cell population in the blood. In this study, the researcher has developed CTC isolation methodologies and used novel culture formulations to expand patient derived CTCs for therapy testing. Furthermore, the researcher identified biomarkers present on CTCs which could select patients for immunotherapies, a current unmet need. This work sets the foundation for a personalized medicine approach to treating head and neck cancer patients.

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Homer, Jarrod James. "Studies on angiogenesis in head and neck squamous cell carcinoma." Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342866.

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Chan, Chiu-lung Richie, and 陳肖龍. "Mucosal melanoma of the head and neck." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632876.

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Wimardhani, Yuniardini. "Molecular Detection Of Disseminated Tumour Cells In Blood And Lymph Nodes In Patients With Head And Neck Squamous Cell Carcinoma; Correlation With Clinical And Pathological Factors And Its Effect On Patients Outcome." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/5121.

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Zimmermann, Miriam. "The tumour microenvironment and response to therapeutic agents in head and neck squamous carcinoma cells." Thesis, University of London, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548044.

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Cheah, Ramsah. "Monitoring the response of head and neck tumour tissue to irradiation using a microfluidic-based approach." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13947.

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Radiotherapy remains the standard treat74ment for head and neck squamous cell carcinoma (HNSCC), however, resistance remains a real clinical problem despite the improvements and development of new treatment strategies. Patient outcome could potentially be improved if the response to irradiation could be predicted allowing alternative treatments to be implemented. The current project has investigated the ability to maintain HNSCC tissue under pseudo in vivo-like conditions using a bespoke microfluidic device. The interrogation of the tissue with irradiation has also been performed with a view to predicting outcome and ultimately personalising medicinal treatment. Following extensive optimisation of key steps in device establishment, e.g. flow rates, serum concentration, oxygen perfusion, using rat liver and human tumour tissue, a series of HNSCC biopsies were divided and placed into parallel microfluidic devices and pieces of each tumour were subjected to single-dose irradiation (5, 10, 15, and 20Gy). Lactate dehydrogenase (LDH) release was measured in effluent collected every 2hr. In five of the tumours (primary n=3; metastatic lymph node n=2), frozen tissue sections were stained for cytokeratin (CK), M30 (detects cleaved CK-18), γH2AX, Ki-67 and for TUNEL. A CK18-labelling index (CK18-LI) was developed by expressing the percentage of apoptotic area (M30) over the total tumour area (CK+ staining). The positive γH2AX, Ki-67 expression and TUNEL were evaluated as positive nuclei within selected tumour areas. Single-dose irradiation induced variable, yet higher, CK18-LI compared with nonirradiated controls. In contrast no statistically significant differences in LDH release were observed between irradiated samples and controls. The percentage of Ki-67 expression reduced dose-dependently but not significantly following on-chip irradiation. Variation in expression profiles of these markers was identified between patients when using the same irradiation regimen demonstrating the potential of current microfluidic irradiation experimentation in monitoring patient’s radiotherapeutic response. In conclusion, microfluidics offers a potential tool in personalised medicine, capable of predicting a tumours response to irradiation prior to clinical administration although further validation experiments are required. The approach has equal applicability to all solid tumours and multiple types of treatment, i.e. chemo-radiation.

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Andrews, Nigel Anthony. "Intrinsic cellular radiosensitivity in head and neck cancer." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367189.

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Boldrup, Linda. "p63 and potential p63 targets in squamous cell carcinoma of the head and neck." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1522.

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Books on the topic "Head and neck tumour"

1

Andrearczyk, Vincent, Valentin Oreiller, and Adrien Depeursinge, eds. Head and Neck Tumor Segmentation. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67194-5.

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H, Qizilbash Ali, Young J. Edward M, and Qizilbash Ali H, eds. Head and neck. 2nd ed. New York: Igaku-Shoin, 1996.

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3

Qizilbash, Ali H. Head and neck. New York: Igaku-Shoin, 1988.

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4

Rahbar, Reza, Carlos Rodriguez-Galindo, John G. Meara, Edward R. Smith, and Antonio R. Perez-Atayde, eds. Pediatric Head and Neck Tumors. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-8755-5.

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5

Head and neck pathology. 2nd ed. Philadelphia, PA: Elsevier Saunders, 2013.

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6

Bruce, Brockstein, and Masters Gregory, eds. Head and neck cancer. Boston: Kluwer Academic, 2003.

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7

I, Chiosea Simion, and Seethala Raja R, eds. Head and neck pathology. New York: Demos Medical Pub., 2011.

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8

E, Thawley Stanley, ed. Comprehensive management of head and neck tumors. 2nd ed. Philadelphia: W.B. Saunders, 1999.

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9

Thakur, Jagdeep S., and Ripu Daman Arora. Operative Surgery for Head and Neck Tumours. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139.

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E, Thawley Stanley, Panje William R, Batsakis John G, and Lindberg Robert D, eds. Comprehensive management of head and neck tumors. Philadelphia: Saunders, 1987.

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Book chapters on the topic "Head and neck tumour"

1

Chaitanya S, Avinash, and Rajeev Gupta. "Hypopharyngeal Tumour." In Operative Surgery for Head and Neck Tumours, 105–10. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139-11.

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Panda, Smriti, and Hitesh Verma. "Oropharyngeal Tumour Surgery." In Operative Surgery for Head and Neck Tumours, 83–104. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139-10.

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Arora, Ripu Daman, and Jagdeep S. Thakur. "Parapharyngeal Tumour Surgery." In Operative Surgery for Head and Neck Tumours, 202–9. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139-20.

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Thakur, Jagdeep S., and Kartik N. Rao. "Sinonasal Tumour Surgery." In Operative Surgery for Head and Neck Tumours, 145–58. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139-14.

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Nagarkar, Nitin M., and Ripu Daman Arora. "Salivary Glands Tumour Surgery." In Operative Surgery for Head and Neck Tumours, 74–82. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780367430139-9.

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Kovács, Adorján F. "Head and Neck." In Locoregional Tumor Therapy, 125–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36572-0_9.

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Kovács, Adorján F. "Head and Neck." In Locoregional Tumor Therapy, 199–211. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-69947-9_8.

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Rao, Chinmay, Suraj Pai, Ibrahim Hadzic, Ivan Zhovannik, Dennis Bontempi, Andre Dekker, Jonas Teuwen, and Alberto Traverso. "Oropharyngeal Tumour Segmentation Using Ensemble 3D PET-CT Fusion Networks for the HECKTOR Challenge." In Head and Neck Tumor Segmentation, 65–77. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67194-5_8.

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Rischin, Danny. "Biomarkers for Immune Modulatory Treatment in Head and Neck Squamous Cell Carcinoma (HNSCC)." In Critical Issues in Head and Neck Oncology, 83–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_6.

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AbstractImmune checkpoint inhibitors have changed the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a minority of patients respond, hence the search for predictive biomarkers. Potential predictive biomarkers for immune checkpoint inhibitors discussed in this chapter include (1) Immune checkpoint ligand expression e.g., PD-L1, (2) biomarkers of a T-cell inflamed tumour microenvironment (TME) such as gene expression profiles of activated T cells, (3) biomarkers of tumour neoepitope burden such as tumour mutation burden (TMB) and (4) multidimensional quantitative techniques. At present only PD-L1 expression has been shown to have clinical utility in head and neck cancer. It enriches for populations more likely to respond, but the false positive predictive value remains high. In the pivotal Keynote−048 trial that established a role for pembrolizumab (anti-PD1) monotherapy and pembrolizumab + chemotherapy as treatment options in first-line R/M HNSCC, primary endpoints included overall survival in defined subgroups based on PD-L1 expression. In this trial the combined positive score (CPS) was used which takes into account PD-L1 expression in tumour and immune cells. Based on this trial regulatory approvals for first-line pembrolizumab in R/M HNSCC require assessment of PD-L1 expression using the CPS. Finally we discuss emerging evidence that locoregionally advanced HPV-associated oropharyngeal cancers that have high expression of CD103 positive CD8 T cells have an excellent prognosis and features that suggest increased probability of responding to anti-PD1/PD-L1, raising the possibility of incorporating these immune therapies as part of a de-escalation trial strategy.

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Spiessl, B., P. Hermanek, O. Scheibe, and G. Wagner. "Head and Neck Tumours." In TNM-Atlas, 4–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-02443-0_2.

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Conference papers on the topic "Head and neck tumour"

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Irlanda, Pacheco-Bravo, Hidalgo-Tobon Silvia, Zaragoza Kena, Reynoso-Noverón Nancy, De Celis-Alonso Benito, and Delgado-Hernandez Rosa. "ADC biomarker for head and neck tumors." In XIII MEXICAN SYMPOSIUM ON MEDICAL PHYSICS. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4901384.

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Duong Dinh, TA, E. Mici, A. Otremba, J. Ilgner, and M. Westhofen. "Neuroendocrine tumors of the head and neck." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1685982.

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Vakoulovskaya, Elena G., Victor V. Shental, N. A. Abdoullin, Yury P. Kuvshinov, T. D. Tabolinovskaia, N. J. Edinak, Boris K. Poddubny, et al. "Photodynamic therapy of head and neck tumors." In BiOS Europe '96, edited by Stanley B. Brown, Benjamin Ehrenberg, and Johan Moan. SPIE, 1996. http://dx.doi.org/10.1117/12.260763.

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4

Makarava, N. I., and M. N. Piatkevich. "TREATMENT PLANNING PROTOCOLS FOR HEAD AND NECK TUMORS IRRADIATION." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-66-69.

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Abstract:

In order to provide high-quality radiation therapy at the National Cancer Center of Belarus, a group of medical physicists developed the first local protocol in Belarus for radiotherapy treatment planning of head and neck tumors patients. The protocol contains grounded practice-oriented recommendations based on the long-term clinical experience of qualified medical physicists in treating patients with head and neck tumors for irradiation using modern linear accelerators.

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Zhao, Baixiang, John Soraghan, Gaetano Di Caterina, and Derek Grose. "Segmentation of Head and Neck Tumours Using Modified U-net." In 2019 27th European Signal Processing Conference (EUSIPCO). IEEE, 2019. http://dx.doi.org/10.23919/eusipco.2019.8902637.

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Nagle, Luz, Amy Mackay Weber, MacLean Hall, Matthew Beatty, J. Trad Wadsworth, Caitlin McMullen, Krupal Patel, Kathryn Vorwald, Christine Chung, and Shari Pilon-Thomas. "Abstract 2178: Expansion of tumor-specific tumor-infiltrating lymphocytes (TIL) from head and neck tumors." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2178.

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Yang, Kyung-Min, WonJoo Kim, Jeong-Mi Lee, and Seong-Jin Kim. "Abstract 4411: DRAK1 overexpressed in head and neck cancer suppresses the TGF-β1 tumor suppressor activity in head and neck cancer cells." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4411.

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Kamrani, Ali, and Maryam Azimi. "Geometrical analysis and predictive modeling of head and neck tumors." In 2014 World Automation Congress (WAC). IEEE, 2014. http://dx.doi.org/10.1109/wac.2014.6935641.

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Mack, Martin G., Thomas J. Vogl, Petra Mueller, Carsten M. Philipp, H. Boettcher, Andre Roggan, M. Juergens, et al. "MR-guided laser-induced thermotherapy of head and neck tumors." In BiOS Europe '95, edited by Stephen G. Bown, Herbert J. Geschwind, Raimund Hibst, Frederic Laffitte, Giulio Maira, Roberto Pini, Hans-Dieter Reidenbach, Hans H. Scherer, and Pasquale Spinelli. SPIE, 1996. http://dx.doi.org/10.1117/12.230307.

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Kumar, Dhruv, Partha Kasturi, Bennett Van Houten, and Sufi Thomas. "Abstract 1139: Tumor-associated fibroblasts facilitate head and neck cancer metabolism." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1139.

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Reports on the topic "Head and neck tumour"

1

Pereira, Daniela, Diana Martins, and Fernando Mendes. Immunotherapy in Head and Neck Cancer When, How and Why? INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0016.

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Poindexter, Samuel E. Comparing Immunohistologic and Demographic Variables of Head and Neck Squamous Cell Carcinoma. Fort Belvoir, VA: Defense Technical Information Center, May 2015. http://dx.doi.org/10.21236/ad1012738.

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LaFiandra, Michael E., and Harry Zywiol. Mounted Combat System Crew Shock Loading: Head and Neck Injury Potential Evaluation. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada469753.

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Halldin, Peter, Sofia Hedenstierna, Karin Brolin, and Hans von Holst. Finite Element Analysis of the Effects of Head-Supported Mass on Neck Responses. Fort Belvoir, VA: Defense Technical Information Center, September 2006. http://dx.doi.org/10.21236/ada456789.

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Shender, Barry, Glenn Paskoff, Greg Askew, Rich Coughlan, and Wayne Isdahl. Head and Neck Loads and Moments Developed During Tactical and Rotary Wing +Gz-Stress. Fort Belvoir, VA: Defense Technical Information Center, January 2000. http://dx.doi.org/10.21236/ada389301.

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Shender, Barry S., Glenn Paskoff, Gregory Askew, Richard Coughlan, and Wayne Isdahl. Determination of Head and Neck Loads and Moments During Tactical and Rotary Wing Maneuvering Acceleration. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada390466.

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Zhang, Dongyuan, Zhengze Wang, Jingwen Li, Chengliang Ren, and Shen Tian. Neutrophil-to-lymphocyte ratio in head and neck cancer prognosis: An updated systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2020. http://dx.doi.org/10.37766/inplasy2020.9.0074.

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Wade, Amber L., Judy L. Dye, Charlene R. Mohrle, and Michael R. Galarneau. Head, Face, and Neck Injuries During Operation Iraqi Freedom II: Results From the US Navy and Marine Corps Combat Trauma Registry. Fort Belvoir, VA: Defense Technical Information Center, January 2006. http://dx.doi.org/10.21236/ada445195.

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Amoroso, Paul J., Nicole S. Bell, Holly Toboni, and Mark Krautheim. A Baseline Historical Analysis of Neck and Back-Related Morbidity in the U.S. Army: Occupational Risks Potentially Related to Head-Supported Mass. Fort Belvoir, VA: Defense Technical Information Center, September 2005. http://dx.doi.org/10.21236/ada440190.

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Zhan, Ze-Jiang, Fang Zhang, Wen-Ze Qiu, Tai-Ze Yuan, and Rong-Hui Zheng. The optimal second-line treatment model for recurrent and/or metastatic head and neck squamous cell carcinoma: a Bayesian network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0041.

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