Dissertations / Theses on the topic 'Head and neck radiotherapy'
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Beasley, William. "Optimising adaptive radiotherapy for head and neck cancer." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/optimising-adaptive-radiotherapy-for-head-and-neck-cancer(96e831b0-751a-454d-8a6d-4dd490b6a88f).html.
Full textBhide, Shreeang Arvind. "Optimization of intensity modulated radiotherapy in head and neck cancer." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511161.
Full textLei, Mary Wei-Ching. "Image guided intensity modulated radiotherapy in head and neck cancer." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600034.
Full textLeslie, Martin David. "Salivary gland function after radiotherapy for head and neck cancer." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341706.
Full textOstyn, Mark R. "Reducing Uncertainty in Head and Neck Radiotherapy with Plastic Robotics." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5558.
Full textAndrews, Nigel Anthony. "Intrinsic cellular radiosensitivity in head and neck cancer." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367189.
Full textPatterson, Joanne Margaret. "Swallowing in head and neck cancer patients treated by (chemo) radiotherapy." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545765.
Full textUrbano, Maria Teresa Guerrero. "Evaluation of intensity modulated radiotherapy in head and neck and pelvic malignancies." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510356.
Full textHo, Kean Fatt. "Optimising dose escalated intensity modulated radiotherapy (IMRT) in head and neck cancer." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508596.
Full textRamadaan, Ihab Safa. "Validation of Deformable Image Registration for Head & Neck Cancer Adaptive Radiotherapy." Thesis, University of Canterbury. Physics and Astronomy, 2013. http://hdl.handle.net/10092/8083.
Full textMaraveyas, Anthony. "Refinement of targeted radiation strategies for the treatment of head and neck squamous cell carcinoma." Thesis, Imperial College London, 1995. http://hdl.handle.net/10044/1/8275.
Full textLundmark, Martin. "Clinical evaluation of atlas-based segmentation for radiotherapy of head and neck tumours." Thesis, Umeå universitet, Institutionen för fysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45571.
Full textBakgrund Atlasbaserad, semiautomatisk segmentering skulle kunna användas för att underlätta den för onkologen tidskrävande uppgiften med att manuellt segmentera strukturer och organ i patienter vid behandlingsplanering inför strålbehandling. Tidigare segmenterade atlaspatienter ger med hjälp av deformeringsalgoritmer segmenteringsförslag för strukturer i den aktuella patienten. Dessa kan sedan kontrolleras och editeras av onkologen med en tidsbesparing gentemot manuell segmentering som följd. En atlas som baserats på en enstaka individ (singelatlas) kan dock ha begränsningar när det gäller att täcka de anatomiska variationer som finns mellan olika patienter. Därför har metoder med fusionering av multipla segmenteringsförslag från en databas bestående av ett antal sedan tidigare segmenterade patienter (fusionerad multipelatlas) potential att ge ett bättre segmenteringsresultat. Syfte Huvudsyftet med arbetet var att undersöka de möjliga tidsbesparingar för onkologen som kan åstadkommas när editering av atlasbaserad segmentering används vid planering inför strålbehandling i huvud- och halsområdet istället för manuell segmentering Material och metoder En kommersiell, atlasbaserad segmenteringsprogramvara (VelocityAI från Nucletron AB) användes i studien. Genom att låta en erfaren onkolog segmentera ett antal CT-studier (11 st) enligt ett vedertaget protokoll skapades en databas av atlaser som sedan, via deformerbara registreringar, kunde generera lika många segmenteringsförslag för en nytillkommen patient. Den enskilda atlas som ansågs mest representativ valdes till att framställa segmenteringsförslaget för metoden med singelatlas. Till metoden med fusionerade multipla atlaser användes en lokalt utvecklad MATLAB-algoritm baserad på viktade distansmappar. Vikterna representerar sannolikheten för förbättrat segmenteringsresultat och baseras på tidigare resultat1 där sannolikheterna bestämts utifrån en beräkning av likheterna mellan bilderna i ett visst område från den specifika segmenteringen. Tio patienter har inkluderats i studien. Varje patient segmenterades tre gånger, (a) manuellt, (b) med singelatlas och (c) med fusionerade multipla atlaser. För metoderna (b) och (c) editerades sedan segmenteringsförslagen av onkologen utan att denne fick använda resultatet från metod (a) som referens. För fallet med fusionerade multipla atlaser, (c), användes databasen med 11 atlaser. Tiden onkologen behövde för segmentering respektive editering av segmenteringsförslaget uppmättes i varje enskilt fall för jämförelse. Onkologen fick även göra en bedömning av hur hjälpsamt segmenteringsförslaget var i samband med editeringen. För utvärdering av resultaten användes Dice’s similaritetskoefficient, Hausdorff’s distansmått samt strukturernas volym. Resultat Resultaten visar på att en tidsbesparing i storleksordningen 40 % är rimlig när onkologen editerar förslag från fusioneringen av multipla atlassegmenteringar i jämförelse med manuell segmentering. Vid användning av singelatlas är motsvarande siffra 21 %. Slutsatser Användandet av atlasbaserad segmentering kan reducera tidsåtgången för segmentering av patienter inför strålbehandling i huvud-halsområdet. 1C. Sjöberg and A. Ahnesjö, Evaluation of atlas-based segmentation using probabilistic weighted distance maps, Manuscript, Uppsala University, 2011
Webster, Gareth John. "Intensity-Modulated Radiotherapy for the Head and Neck : Improvements in Planning and Delivery." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509060.
Full textBrown, Elizabeth M. "Biologically guided adaptive radiotherapy treatment planning for virally-mediated head and neck cancer." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/98899/1/Elizabeth_Brown_Thesis.pdf.
Full textTang, Nin-fai Francis, and 鄧年輝. "Monte Carlo dose calculations in quality assurance for IMRT of head and neck cancers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203797.
Full textNewbold, Katie Lindsay. "The application of advanced imaging techniques to radiotherapy planning in head and neck cancer." Thesis, Institute of Cancer Research (University Of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498512.
Full textBerthon, Beatrice. "Optimisation of Positron Emission Tomography based target volume delineation in head and neck radiotherapy." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/69184/.
Full textKuo, Michael Jeo-Ming. "Aberrations of chromosome arms 5q and 8p in squamous cell carcinomas of the head and neck." Thesis, University of Birmingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340558.
Full textChan, Sze-man, and 陳詩敏. "A clinical guideline to manage radiotherapy induced oral mucositis in head and neck cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44622934.
Full textRyalat, Mohammad. "Automatic construction of immobilisation masks for use in radiotherapy treatment of head-and-neck cancer." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66573/.
Full textCarr, Simon David. "Assessing the effects of radiotherapy on head and neck squamous cell carcinoma using microfluidic techniques." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:8396.
Full textPow, Ho-nang Edmond. "Oral health and quality of life after intensity-modulated head and neck radiotherapy for nasopharyngeal carcinoma /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36749333.
Full textPow, Ho-nang Edmond, and 鮑浩能. "Oral health and quality of life after intensity-modulated head and neck radiotherapy for nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501565X.
Full textNguyen, Nam, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, et al. "Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer." BioMed Central, 2012. http://hdl.handle.net/10150/610349.
Full textGoodall, Benjamin David. "An exploration of the experience of undergoing radiotherapy for head and neck cancer patients : a biopsychosocial approach." Thesis, University of Hull, 2007. http://hydra.hull.ac.uk/resources/hull:15098.
Full textSCALCO, ELISA. "Evaluation of morphological and structural variations in parotid glands during radiotherapy in the head and neck district." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50419.
Full textRodrigues, Joana de Matos. "From genes to radioresistance in head and neck squamous cell carcinoma." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16133.
Full textHead and Neck Cancers (HNC) are a group of tumours located in the upper aero-digestive tract. Head and Neck Squamous Cell Carcinoma (HNSCC) represent about 90% of all HNC cases. It has been considered the sixth most malignant tumour worldwide and, despite clinical and technological advances, the five-year survival rate has not improved much in the last years. Nowadays, HNSCC is well established as a heterogeneous disease and that its development is due to accumulation of genetic events. Apart from the majority of the patients being diagnosed in an advanced stage, HNSCC is also a disease with poor therapeutic outcome. One of the therapeutic approaches is radiotherapy. However, this approach has different drawbacks like the radioresistance acquired by some tumour cells, leading to a worse prognosis. A major knowledge in radiation biology is imperative to improve this type of treatment and avoid late toxicities, maintaining patient quality of life in the subsequent years after treatment. Then, identification of genetic markers associated to radiotherapy response in patients and possible alterations in cells after radiotherapy are essential steps towards an improved diagnosis, higher survival rate and a better life quality. Not much is known about the radiation effects on cells, so, the principal aim of this study was to contribute to a more extensive knowledge about radiation treatment in HNSCC. For this, two commercial cell lines, HSC-3 and BICR-10, were used and characterized resorting to karyotyping, aCGH and MS-MLPA. These cell lines were submitted to different doses of irradiation and the resulting genetic and methylation alterations were evaluated. Our results showed a great difference in radiation response between the two cell lines, allowing the conclusion that HSC-3 was much more radiosensitive than BICR-10. Bearing this in mind, analysis of cell death, cell cycle and DNA damages was performed to try to elucidate the motifs behind this difference. The characterization of both cell lines allowed the confirmation that HSC-3 was derived from a metastatic tumour and the hypothesis that BICR-10 was derived from a dysplasia. Furthermore, this pilot study enabled the suggestion of some genetic and epigenetic alterations that cells suffer after radiation treatment. Additionally, it also allowed the association of some genetic characteristics that could be related to the differences in radiation response observable in this two cell lines. Taken together all of our results contribute to a better understanding of radiation effects on HNSCC allowing one further step towards the prediction of patients’ outcome, better choice of treatment approaches and ultimately a better quality of life.
Cancro da Cabeça e Pescoço refere-se a um grupo de tumores que aparecem no trato aerodigestivo superior, sendo que o carcinoma das células escamosas da cabeça e pescoço (CCECP) corresponde a mais de 90% de todos os casos de cancro nesta região. Foi considerado o sexto tumor mais maligno em todo o mundo e, apesar de todos os avanços tecnológicos e clínicos, a taxa de sobrevivência a cinco anos não melhorou significativamente nas últimas décadas. Atualmente sabe-se que o CCECP é uma doença bastante heterogénea que se desenvolve devido à acumulação de alterações genéticas e epigenéticas. Alguns dos grandes problemas associados a este tipo de cancro são o diagnóstico em fase tardia da doença e os poucos resultados terapêuticos. Uma das escolhas terapêuticas para o CCECP é a radioterapia, no entanto, esta tem diversos inconvenientes, como a radioresistência adquirida por algumas células tumorais, que se associam a piores prognósticos. Um aumento do conhecimento na área da biologia da radiação é necessário para melhorar esta opção terapêutica, evitando futuros efeitos tóxicos e fornecendo uma melhor qualidade de vida nos anos subsequentes ao tratamento. Desta forma, a identificação de marcadores moleculares associados quer a uma resposta à radioterapia, quer a possíveis alterações celulares após tratamento com radiação, é essencial para melhorar o diagnóstico, taxa de sobrevivência e qualidade de vida destes doentes. Adicionalmente, existe uma grande falha no conhecimento em relação aos efeitos da radiação nas células, como tal, o principal objetivo deste estudo foi o de contribuir para um conhecimento mais alargado do efeito da radiação em doentes com CCECP. Para isso foram utilizadas duas linhas comerciais celulares, HSC-3 (derivada de um tumor metastático da língua) e BICR-10 (derivada de um tumor da mucosa bucal), que foram caracterizadas com recurso a aCGH, MS-MLPA e citogenética convencional. Estas linhas foram submetidas a diferentes doses de radiação e as alterações genéticas e de metilação pós tratamento foram determinadas. Estes resultados demonstraram uma grande variação de resposta à radiação para estas duas linhas celulares, permitindo a conclusão que a linha HSC-3 é mais radiossensível que a linha BICR-10. Tendo isto em mente, procedeu-se a análise da morte celular, ciclo celular e danos no DNA de forma a tentar compreender esta diferença. A caracterização genética de ambas as linhas celulares permitiu corroborar que a linha HSC-3 era derivada de um tumor metastático e sugeriu que a linha celular BICR-10 estaria associada a um estado de displasia. Para além disto, foi possível analisar alterações genéticas e epigenéticas ocorridas após irradiação e associar determinados perfis genéticos a uma melhor ou pior resposta à radiação. Em suma, os nossos resultados contribuiram para um conhecimento mais aprofundado dos efeitos da radiação no CCECP possibilitando, no futuro, melhores opções de tratamento e uma melhor qualidade de vida para estes doentes.
Isenring, Elisabeth A. "The impact of nutrition support in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/36795/1/36795_Digitised%20Thesis.pdf.
Full textKawamura, Mitsue. "A scoring system predicting acute radiation dermatitis in patients with head and neck cancer treated with intensity-modulated radiotherapy." Kyoto University, 2019. http://hdl.handle.net/2433/244519.
Full textZziwa, Aloysious. "A RADIOTHERAPY PLAN SELECTOR USING CASE-BASED REASONING." Master's thesis, Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/85055.
Full textM.S.E.
Developing a head and neck cancer treatment plan for a candidate of Intensity Modulated Radiation Therapy (IMRT) requires extensive domain knowledge and subjective experience. Therefore, it takes a cancer treatment team at least 2 to 3 days to develop such a plan from scratch. Many times the team may not use a reference plan. Sometimes, to reduce the amount of time taken to generate each treatment plan, these experts recall a patient, whose plan they recently prepared, and who had similar symptoms as the candidate. Using this recalled patient's plan as the starting point, the cancer treatment team modifies it based on the differences in the symptoms of the new candidate and those of the reference patient record. The resultant plan after modification is presented as the new treatment plan for the oncologist to evaluate its suitability for treatment of the candidate. This approach is heavily dependent on the team's choice of the reference patient record. Choosing a starting treatment plan where the patient's symptoms are not the closest to the new candidate implies that more time will be spent modifying the plan than is necessary and the resultant treatment plan may not be the best achievable under the same circumstances given a better starting plan. Therefore, the team's bias in choosing the starting plan may affect the quality of treatment plan that is finally produced for the candidate. This thesis proposes a system that behaves like an un-biased radiotherapy expert - following a similar process and standards as the human experts and which searches the entire IMRT patient database and returns the record (with patient symptoms and treatment plan) for a patient whose symptoms are most similar to the candidate's symptoms. It takes in the new candidate's information (from diagnosis, scans of the tumor and interviews with the candidate), searches the database and prints out a patient record showing another patient's treatment plan as the suggested starting point for generating the new plan. The system uses Case-Based Reasoning (CBR) because it mimics the experts' approach since it makes use of previous successes and shuns reasoning that has failed in the past. This occurs by considering only treatment plans that have been implemented successfully on patients in the hospital archive. For this thesis, CBR is applied using fuzzy IF-THEN rules to search the patient database. Fuzzy logic is used because it can handle imprecise expressions commonly used in natural language to determine the appropriate weight of the patient attributes in the search process. Filtering of patient records based on parameter value ranges is also used to reduce the number of records that have to be compared. The system code developed for this thesis was prepared in Java and C Language Integrated Production System (CLIPS) using the Java Expert System Shell (JESS). This system is part of a bigger expert system that is being prepared by the Intelligent Systems Applications Center (ISAC) for Thomas Jefferson University Hospital, expected to generate a radiotherapy plan for a patient designated for IMRT treatment. Initial results from the developed prototype prove the viability of selecting similar patients using CBR. It is important to note that the overall objective of the project is to build a system that effectively aids decision support by the IMRT team when generating a new treatment plan and not to replace them. The team is expected to use the generated plan as a starting point in determining a new treatment plan. If the generated plan is sufficient, the oncologist and their team will have to check this plan (in their various capacities) against expected standards for quality control before passing it on for implementation. This will save them time in planning and allow them to focus more on the patient's needs hence a higher quality of life for the patient after treatment.
Temple University--Theses
Helal, Azza Mahmoud. "The effect of patient anatomy on optimised intensity modulated radiotherapy dose distributions for head and neck and prostate cancer." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438639.
Full textZheng, Xiangpeng. "Specificity and feasibility of HN-5 peptide for diagnosis and targeted therapy of head and neck squamous cell carcinomas : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1400957411&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Full textGulati, Shuchi. "Phase-1 Study of Metformin in Combination with Concurrent Cisplatin and Radiotherapy in Patients with Locally Advanced Head and Neck Cancer." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593171585877322.
Full textLochner, Johann Georg. "A comparison of two saliva substitutes in the management of xerostomia during radiotherapy for cancer of the head and neck." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9540_1257166768.
Full textThe aim of the study is to compare the palliative efficacy of two saliva substitutes (Sinspeek and Xerostom) in patients during radiotherapy for cancer of the head and neck. This crossover randomised controlled clinical trial was carried out on twenty-five patients with malignant tumours of the head and neck, following four weeks of radiotherapy at tygerberg hospital. The benefit of saliva substitutes to ameliorate the effects of xerostomia is well established and proper advice and access to relevant preparations is essential.
Marcu, Loredana Gabriela. "Deterministic modelling of kinetics and radiobiology of radiation-cisplatin interaction in the treatment of head and neck cancers." Title page, contents and abstract only, 2004. http://hdl.handle.net/2440/37961.
Full textThesis (Ph.D.)--School of Chemistry and Physics, 2004.
Satherley, Thomas William Scott. "The impact of plan complexity on the accuracy of VMAT for the treatment of head and neck cancer." Thesis, University of Canterbury. Physics, 2015. http://hdl.handle.net/10092/10584.
Full textPOLI, MARIA E. R. "Definição do volume de planejamento do alvo (PTV) e seu efeito na radioterapia." reponame:Repositório Institucional do IPEN, 2007. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11552.
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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Larsson, Maria. "Eating problems in patients with head and neck cancer treated with radiotherapy : Needs, problems and support during the trajectory of care." Doctoral thesis, Karlstad University, Faculty of Social and Life Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-777.
Full textAim: The overall aim of this thesis was to acquire knowledge about daily life with focus on eating problems during the trajectory of care for patients with head and neck cancer treated with radiotherapy. Method: The data in study I were gained from medical and nursing records of 50 patients. Documented parameters of eating problems, their causes and consequences, and undertaken interventions were collected before treatment, during radiotherapy, and one, six, and twelve months after completion of treatment, using a study-specific audit instrument. Data were analysed with descriptive and inferential non-parametric statistics. In study II eight patients were interviewed during the radiotherapy treatment period with focus on experiences of eating problems. In study III nine patients were interviewed six to twelve weeks after treatment with the focus on experiences of daily life during the trajectory of care having eating problems. In study IV twelve patients were interviewed about their conceptions of the significance of a supportive nursing care clinic during the whole trajectory of care. Data were analysed with interpretative phenomenology (II, III) and phenomenography (IV). Findings: The four studies showed that being a patient in the trajectory of care often meant that life was disturbed and threatened. This was partly due to the eating problems and their consequences, which could occur during the whole trajectory of care (I, III, IV) but was experienced as most intense and severe during radiotherapy (II) and the nearest weeks after completion of radiotherapy (III, IV). The disturbances and threats experienced due to eating problems could affect the whole person as they were physical (I-IV), psychological, social and existential (II, III). The experiences of eating problems due to the tumour and its treatment and the experience of having cancer per se were strongly connected as one phenomenon, which disturbed and threatened the informants’ daily life. The other part that disturbed the patients’ life was the waiting in suspense. A long and trying waiting in uncertainty was experienced due to lack of knowledge and support, practical as well as emotional. This was most pronounced during pauses in radiotherapy (III) and after completion of the treatment when the lack of support from the health care was obvious (I, II, III). The patients were then most often left to their own devices. In order to endure, they needed both inner strength, described as own coping strategies, and strength from outside, described as support from family, friends and health care professionals (II, III). The nurse clinic was found to give a hand to hold during the whole trajectory of care (IV). It could meet these patients’ needs of knowledge, care and support, both concerning practical measures related to the eating problems and other side-effects of the treatment, and concerning their emotional needs. In addition the nurse clinic could support the relatives in their worries and anxiety (IV). Conclusion: This thesis showed the necessity of continuous assessment, treatment and evaluation of patients’ problems, and the patients’ needs of information and support throughout the trajectory of care.
Nutting, Christopher. "Can intensity-modulated radiotherapy (IMRT) be used to reduce toxicity and improve tumour control in patients with head and neck cancer?" Thesis, City University London, 2012. http://openaccess.city.ac.uk/1128/.
Full textWegoye, Emmanuel. "Radiotherapy for head and neck paragangliomas: A 10 year retrospective review 2005-2014 at Groote Schuur Hospital and UCT Private academic hospital." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30840.
Full textDe, Pomeroy-Legg Jeanita. "Prevalence of side-effects and change in nutritional status during radical radiotherapy for head and neck malignancies at Tygerberg Academic Hospital, Western Cape, South Africa." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/1492.
Full textBlades, Rae. "A cost-effectiveness analysis of a silicone film-forming gel versus 10% glycerine in patients with head and neck cancer." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/198193/1/Rae_Blades_Thesis.pdf.
Full textConibear, John Richard. "Assessment of target volume and organ at risk contouring variability within the context of UK head and neck and lung cancer radiotherapy clinical trials." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045105/.
Full textGeorgi, Alexander. "Lokal fortgeschrittene Kopf-Hals-Tumoren- Eine retrospektive, monoinstitutionale Studie zur Beurteilung der postoperativen Radiochemotherapie im klinischen Alltag." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-130129.
Full textAlbuquerque, Danielle Frota de. "Avaliação dos parâmetros de halitose e sialometria em pacientes submetidos à radioterapia de cabeça e pescoço." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/25/25132/tde-14062007-132546/.
Full textThe aim of this study was to verify the halitosis parameters in patients who had received head and neck radiotherapy. The degree of halitosis was determined through the presence of tongue coating, classified according to its dry weight; the salivary flow rate, the BANATM test and HalimeterTM oral measurements. A total of 48 subjects were examined, which were divided into three groups. Group 1 was consisted for patients with good oral health and no complains of bad breath; Group 2 consisted of patients with bad oral health condition and Group 3 comprised individuals who had received head and neck radiotherapy. The concentration of Volatile Sulfur Compounds (VSC) was assessed by means of a portable sulfide monitor (HalimeterTM) and the values were correlated to the resting and stimulated salivary flow rate and to the BANATM test with material collected from the tongue coating and its dry weight. Halitosis was quantified before and after the removal of the tongue coating and the data was analyzed by means of the ANOVA test. The correlation among salivary flow rate, weight of the tongue coating and HalimeterTM oral measurements was evaluated by the Pearson test. The results showed a statistically significant difference between group 1 and 3, and between groups 1 and 2. A relationship between the presence of tongue coating and the VSC levels was also demonstrated. In concerning to the salivary flow rate, there was a statistically significant reduction between group 1 and 3, and group 2 and 3. In the accordance of this study, halitosis can be considered a side effect of radiotherapy, tied with the hyposalivation and deficient oral health.
Alencar, Anelise Ribeiro Peixoto. "Tratamento da mucosite oral radio e quimioinduzida: comparação entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-01072011-131133/.
Full textIn this clinical study verified the effects of low intensity laser in the prevention and treatment of oral mucositis radio and/or chemical induced. Thirty one patients with head and neck cancer were selected before being submitted to cancer exclusive radiotherapy or radio and associated chemotherapy. The patients were distributed into three randomly groups as follows: group 1- (control) conventional medicine treatment; group 2 conventional medicine treatment and daily lasertherapy as soon as grade two oral mucositis appeared; group 3 conventional medicine treatment and daily lasertherapy to be initiated immediately before radiotherapy sessions.The irradiation parameters were: wavelength of 660nm, potency of 100mW, continuous mode, punctual application, 2J energy on thirty pre-determined 30 points, with 20s of exposure per point. The control group received medical treatment which consisted in using a set of preventive and therapeutic approach for acute radiation-induced adverse effects. Results were evaluated observing occurrence and grade of oral mucositis, score of pain, loss of body mass, use of nasogastric sound line, internment and interruption of oncologic treatment due to oral mucositis. The results showed that the preventive protocol as used was the most effective in prevention and treatment of oral mucositis and that its daily application contributed in relieving the painful symptomatology so collaborating to maintain and/or bettering the life quality of oncologic patients.
Silva, Ana Margarida Abreu Rodrigues da. "A radioterapia em patologia oncológica de cabeça e pescoço: impacto na qualidade de vida e na saúde oral." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3407.
Full textO cancro é um problema de saúde pública a nível mundial, devido à sua crescente prevalência, com grande impacto individual e social. Têm-se verificado progressos importantes no tratamento oncológico, aumentando a expectativa de vida dos doentes, pelo que é de extrema importância para a sua recuperação e reintegração na sociedade, melhorar a Qualidade de Vida Relacionada com a Saúde (QdVRS) dos mesmos. A radioterapia é uma das modalidades terapêuticas mais utilizadas no tratamento do patologia oncológica de cabeça e pescoço, podendo estar associada ou não à cirurgia ou quimioterapia. No entanto, apesar do tratamento radioterápico visar atingir apenas as células neoplásicas, pode provocar efeitos secundários nocivos nas células normais da zona irradiada, interferindo na QdVRS do doente ou mesmo alterando a evolução do próprio tratamento. Algumas das complicações mais frequentes da radioterapia na cavidade oral são a xerostomia, mucosite, disfagia, candidose, entre outras. Assim, o Médico Dentista tem um papel fundamental na equipa multidisciplinar de tratamento oncológico, permitindo minimizar a frequência e morbilidade das complicações decorrentes da doença ou do seu tratamento e, consequentemente, melhorar a QdVRS destes doentes. Neste estudo pretende-se avaliar o impacto do tratamento radioterápico na QdVRS dos doentes oncológicos de cabeça e pescoço. Para isso, 91 doentes oncológicos de cabeça e pescoço do Instituto Português de Oncologia Francisco Gentil do Porto (IPOPFG) responderam a dois questionários diferentes sobre QdVRS: EORTC QLQ-C30 (avaliação geral da QdVRS) e QLQ-H&N35 (módulo específico para pacientes com patologia oncológica de cabeça e pescoço). Os resultados obtidos indicam que aquando do diagnóstico, a maioria dos tumores encontra-se em estádios avançados da doença (58.5%), sendo a QdVRS dos homens mais afectada comparativamente à das mulheres. Conclui-se que é de extrema importância a sensibilização da população para o cancro oral e a necessidade de exames de rotina da cavidade oral de modo a permitir o diagnóstico precoce da doença. Due to its increasing prevalence cancer is a public health problem worldwide with huge individual and social impact. There have been significant advances in cancer treatment, increasing patients’ life expectancy. Thus it is of utmost importance to their recovery and reintegration into society to improve patients’ Health-Related Quality of Life (HRQoL). Radiation therapy is one of the most used therapies in the treatment of the head and neck cancer, and may be used together with surgery or chemotherapy. However, despite aiming at targeting only the neoplastic cells, it can cause harmful side effects in normal cells of the radiated area, interfering in the patient's HRQoL or even changing the evolution of the treatment itself. Some of the most frequent complications of radiotherapy in the oral cavity are xerostomy, mucositis, dysphagia, candidiasis, among others. So, the Dentist has a fundamental role in the multidisciplinary team of oncological treatment, minimizing the frequency and morbidity of the complications arising from the disease or its treatment and, consequently, improving the HRQoL of these patients. This study aims to evaluate the impact of radiation treatment on the HRQoL of patients with head and neck cancer. To do this, 91 patients with head and neck cancer being treated at Instituto Português de Oncologia Francisco Gentil (Portuguese Institute of Oncology Francisco Gentil - IPOPFG), in Porto, answered to two different questionnaires on HRQoL: EORTC QLQ-C30 (general assessment of HRQoL) and QLQ-H&N35 (specific module given to patients with head and neck cancer). The results obtained indicate that at the time of diagnosis, most tumors are in advanced stages of the disease (58.5%), the HRQoL of men being more affected when compared to that of women. It is concluded that it is of utmost importance the awareness of the population to oral cancer and the need for routine examinations of the oral cavity to allow for early diagnosis of the disease.
Duma, Marciana Nona [Verfasser], Hans C. W. E. [Akademischer Betreuer] Geinitz, Jürgen [Akademischer Betreuer] Debus, and Michael [Akademischer Betreuer] Molls. "The impact of image guided radiotherapy in head and neck cancers:soft tissue changes, dosimetric consequences and adaptive radiotherapy / Marciana-Nona Duma. Gutachter: Jürgen Debus ; Hans C.-W. E. Geinitz ; Michael Molls. Betreuer: Hans C.-W. E. Geinitz." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/103151211X/34.
Full textALENCAR, ANELISE R. P. "Tratamento da mucosite oral radio e quimioinduzida: comparacao entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade." reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9632.
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Chan, King Chong. "Jaw Bone Changes on Panoramic Imaging after Head and Neck Radiotherapy." Thesis, 2012. http://hdl.handle.net/1807/33363.
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