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Academic literature on the topic 'HCU database'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "HCU database"

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Hajek, André, Benedikt Kretzler, and Hans-Helmut König. "Personality, Healthcare Use and Costs—A Systematic Review." Healthcare 8, no. 3 (September 9, 2020): 329. http://dx.doi.org/10.3390/healthcare8030329.

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Background: Thus far, there is a lack of a systematic review synthesizing empirical studies that analyze the link between personality factors and healthcare use (HCU) or costs. Consequently, the purpose of our systematic review is to give an overview of empirical findings from observational studies examining the association between personality factors and HCU or costs. Methods: PubMed, PsycINFO, and NHS EED (NHS Economic Evaluation Database) were searched. Observational studies examining the association between personality factors and HCU costs by using validated tools were included. Two reviewers performed study selection and data extraction and evaluated the study quality. Findings were synthesized qualitatively. Results: In total, n = 15 studies (HCU, n = 14; cost studies, n = 1) were included in the final synthesis. A few studies point to an association between conscientiousness and HCU (with mixed evidence). Some more evidence was found for an association between higher agreeableness, higher extraversion, and higher openness to experience and increased HCU. The majority of studies analyzed found a link between higher neuroticism and increased HCU. Conclusion: Personality factors, and particularly neuroticism, are associated with HCU. This knowledge is important to manage healthcare use. However, future research based on longitudinal data and studies investigating the link between personality characteristics and costs are required.
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Von den Hoff, Daan W., Floor A. C. Berden, Femke Atsma, Arnt F. A. Schellekens, and Joost P. H. Drenth. "Against All Odds? Addiction History Associated with Better Viral Hepatitis Care: A Dutch Nationwide Claims Data Study." Journal of Clinical Medicine 11, no. 4 (February 21, 2022): 1146. http://dx.doi.org/10.3390/jcm11041146.

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The elimination of viral hepatitis in target populations is crucial in reaching WHO viral hepatitis elimination goals. Several barriers for the treatment of viral hepatitis in people with addictive disorders have been identified, yet nationwide data on hepatitis healthcare utilization (HCU) in these patients are limited. We investigated whether a history of addictive disorder is associated with suboptimal hepatitis HCU, indicating failure to receive diagnostic care or treatment. We identified all newly referred viral hepatitis patients in the Netherlands between 2014 and 2019 by query of the Dutch national hospital claims database. Each patient’s first year of HBV or HCV care activities was collected and clustered in two categories, ‘optimal’ or ‘suboptimal’ hepatitis HCU. Optimal HCU includes antiviral therapy. We tested the association between addiction history and HCU, adjusted for sex, age, migrant status, and comorbidity. In secondary analyses, we explored additional factors affecting hepatitis HCU. We included 10,513 incident HBV and HCV patients, with 13% having an addiction history. Only 47% of all patients achieved optimal hepatitis HCU. Addiction history was associated with less suboptimal HCU (adjusted OR = 0.73, 95% CI = 0.64–0.82). Migration background was associated with suboptimal HCU (OR = 1.62, 95% CI = 1.50–1.76). This study shows that addiction history is associated with higher viral hepatitis HCU; thus, this population performs better compared to non-addicted patients. However, less than 50% of all patients received optimal hepatitis care. This study highlights the need to improve hepatitis HCU in all patients, with a focus on migrant populations. Linkage to care in the addicted patients is not studied here and may be a remaining obstacle to be studied and improved to reach WHO viral hepatitis elimination goals.
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Satwani, Prakash, Ruta Brazauskas, Staci D. Arnold, Naya He, Yimei Li, Richard Aplenc, Matt Hall, et al. "A Study of Predictors of Clinical Outcomes and Healthcare Utilization in Children with Sickle Cell Disease Undergoing Allogeneic Hematopoietic Cell Transplantation." Blood 126, no. 23 (December 3, 2015): 528. http://dx.doi.org/10.1182/blood.v126.23.528.528.

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Abstract Introduction: Current advances in allogeneic hematopoietic cell transplant (alloHCT) may warrant a paradigm shift in managing children with sickle cell disease (SCD). This study characterizes the clinical outcomes and health care utilization (HCU) of alloHCT for pediatric SCD. We hypothesize that early alloHCT will have improved clinical outcomes, and decreased HCU. Methods: The Center for International Blood and Marrow Transplant Research database was used to identify children 21 years or less with alloHCT for SCD in the United States. Patient data included comprehensive research forms (CRF) from 2000-13 and transplant essential data (TED) forms from 2000-11. CRFs provided clinical risk factors associated with overall survival, graft failure, grade III-IV acute GVHD, and GVHD related event free survival (GREFS) - the survival free of graft failure, chronic GVHD, or death. Risk factors included age, gender, performance status, year of alloHCT, prior SCD complications and therapy, CMV status, donor type, conditioning regimen, and GVHD prophylaxis. Due to low event rates and sample size, only univariate analysis of risk factors was performed. TED data was merged with Pediatric Health Information System (PHIS) inpatient data using a probabilistic merging algorithm to determine risk factors and clinical outcomes associated with HCU. Available PHIS adjusted cost data was used to determine the total adjusted cost for all inpatient admissions per patient per hospital day. To standardize these costs, the total adjusted cost per 30 hospital days was calculated for each patient and used as the primary HCU outcome. HCU outcomes were analyzed for the alloHCT year, day 0 to day +365. Results: CRF data for 161 patients showed an overall survival at 2 years of 90% (95% confidence intervals [CI] 85-95%): 96% (95% CI 89-100%) for related and unrelated cord blood transplant (CBT), 94% (95% CI 86-98%) matched siblings (MSD), and 74% (95% CI 54-90%) matched unrelated donors (MUD, p=0.002). All deaths occurred among children with pre-alloHCT complications of SCD, and deaths were due to organ failure (37.5%), infections (25%), GVHD (6.25%). Risk of death was significantly higher for children ≥10 years old (HR 21, p=0.003) and MUD compared to MSD (HR 5.88, p=0.005) but lower with cyclosporine A (CSA) GVHD prophylaxis versus FK506 (HR 0.33, p=0.031). 75% of deaths occurred before day +42. Cumulative acute GVHD incidence at day 100 was 14% (95% CI 9-20%)and was associated with age ≥10yrs (HR 2.63, p=0.035). Chronic GVHD incidence was 31% (95% CI 23-38%) at 2yrs, and factors associated were age ≥10yrs (HR 1.92, p=0.034), MUD vs MSD (HR 2.53, p=0.017), and CSA vs FK506 prophylaxis (HR 0.48, p=0.018). Chronic GVHD risk increased significantly after 2006 (HR 2.81, p=0.018). The 2yr GREFS was 64% (95% CI 56-71%). Age ≥10yrs (HR 2.2, p=0.005), MUD (vs MSD, HR 3.00, p=0.002) and CSA prophylaxis (vs FK506, HR 0.49, p=0.011) were significantly associated with this outcome. Among the 175 patients with combined TED and PHIS data, the median total adjusted cost was $117,393 per 30 hospital days per patient (range: $36,244-$515,640) during the alloHCT year with a median of 53 hospital days per patient (range: 16-304). Age ≥10yrs and HCU were not significantly associated (p=0.775). MSD had the lowest HCU compared to CBT and unrelated transplants (p<0.001). CBT and peripheral blood stem cells were associated with higher HCU compared to bone marrow (p=0.004). Increased HCU was associated with prior stroke (p=0.0004) and pain crises (p=0.0094) but not acute chest syndrome (p=0.2913). Overall SCD complication and severity indices correlated with increased HCU (p=0.052, p=0.0219, respectively). Conclusions: AlloHCT outcomes in children with SCD were linked to age and donor type suggesting that early alloHCT before age 10 years is preferred. Specifically, SCD severity and MUD alloHCT are associated with poorer outcomes and increased HCU. This supports the recommendation of early alloHCT, prior to onset of SCD complications, for children with SCD and an available MSD. Donor source and type had a significant impact on both outcomes and HCU. CBT outcomes were similar to MSD bone marrow; yet CBT had higher HCU suggesting additional analysis is needed to determine if the clinical benefit outweighs the cost. Further analysis is also needed to better understand and mitigate risk factors associated with poor outcomes and increased HCU following MUD alloHCT. Disclosures Arnold: Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program: Other: award. Hahn:NIH/NHLBI: Research Funding; Novartis: Equity Ownership.
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Newman, Lawrence, Pamela Vo, Lujia Zhou, Cristina Lopez Lopez, Andy Cheadle, Melvin Olson, and Juanzhi Fang. "Health Care Utilization and Costs in Patients With Migraine Who Have Failed Previous Preventive Treatments." Neurology: Clinical Practice 11, no. 3 (April 1, 2021): 206–15. http://dx.doi.org/10.1212/cpj.0000000000001076.

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ObjectiveTo characterize health care utilization (HCU) and associated costs among patients with migraine categorized by the number of preventive treatment failures (TFs; 1 TF, 2 TFs, and 3+ TFs) using real-world data.MethodsThis retrospective analysis identified adults with incident migraine diagnosis in the IBM MarketScan Commercial and Medicare Supplemental database between January 1, 2011, and June 30, 2015. TF was defined in the 2 years after the first migraine diagnosis period. One TF, 2 TFs, and 3+ TFs were defined as patients who had received only 2 preventive treatments (PTs), 3 PTs, and 4+ PTs in the 2-year period, respectively. A negative binomial model was used to analyze HCU data, and a 2-part model was used for cost data controlling for the preindex Deyo-Charlson Comorbidity Index.ResultsOverall, 24,282 patients with incident migraine who had failed at least 1 PT were included in the analysis. Of these, 72.7% (n = 17,653) had 1 TF, 20.2% (n = 4,900) had 2 TFs, and 7.1% (n = 1,729) had 3+ TFs. Adjusted annualized rates of all-cause and migraine-specific HCU increased with an increase in the number of TFs (1.4–4 times higher; all p < 0.0001 vs 1 TF). The mean total all-cause health care costs were higher by $3,732 (95% confidence interval [CI]: $2,708–$4,588) in patients with 2 TFs and by $8,912 (95% CI: $7,141–$10,822) in patients with 3+ TFs vs those with 1 TF. Outpatient costs were the key drivers of differences in health care costs.ConclusionsTF in patients with migraine was associated with a substantial resource and cost burden, which increased with the number of TFs.
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Takada, Yosuke, and Yasuhiro Otomo. "Study of Medical Supply and Demand Balance for the Nankai Trough Earthquake." Prehospital and Disaster Medicine 34, s1 (May 2019): s44. http://dx.doi.org/10.1017/s1049023x19001079.

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Introduction:The Nankai Trough, marking the boundary between the Eurasian Plate and the Philippine Sea Plate, is forecasted to create a tragic earthquake and tsunami within 30 years.Aim:To clarify the gap between medical supplies and demand.Methods:Collected the data of the estimation of injured persons from each prefecture throughout Japan, and also the number of Intensive Care Unit (ICU) and High Care Unit (HCU) beds in Japan from the Ministry of Health database. We re-calculated the number of severe cases based on official data. Moreover, we calculated the number of beds of hospitals with the capacity to receive severe patients.Results:The total number of disaster base hospitals is 723 hospitals with 6556 ICU beds, and 545 hospitals have 5,248 HCU beds throughout Japan. When the Nankai Trough earthquake occurs, 187 disaster base hospitals would be located in the area with seismic intensity 6-upper on the Japanese Seismic Intensity Scale of 0-7, and 79 disaster base hospitals would be located in the tsunami inundation area. The estimated total number of injured persons is 661,604 including 26,857 severe cases, 290,065 moderate cases, and 344,682 minor cases.Discussion:Even if all ICU and HCU beds are usable for severe patients, there will be 15,053 more beds needed. The Cabinet Office of Japan assumes that 60% of hospital beds would not be able to be used in an area of the seismic intensity of 6-upper. If 80% of beds are used in the non-disaster time, the number of beds which are usable at the time of a disaster will decrease more. The beds needed for severe patients would be significantly lacking when the Nankai Trough earthquake occurs. It will be necessary to start treatment of the severe patients who are “more likely to be saved more.”
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Ouattara, Eric, Amelie Bruandet, Aurélie Borde, Xavier Lenne, Florence Binder-Foucard, Maggie Le-bourhis-zaimi, Joris Muller, et al. "Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database." BMJ Open Respiratory Research 8, no. 1 (October 2021): e001002. http://dx.doi.org/10.1136/bmjresp-2021-001002.

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ObjectiveTo explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or a hospital care unit (HCU).DesignRetrospective cohort analysis using the French national (Programme de médicalisation des systèmes d’information) database.SettingAny public or private hospital in France.Participants98 366 patients admitted with COVID-19 for more than 1 day during the first semester of 2020 were included. The underlying conditions were retrieved for all contiguous stays.Main outcome measuresIn-hospital mortality and associated risk factors were assessed using frailty Cox models.ResultsAmong the 98 366 patients included, 25 765 (26%) were admitted to a CCU. The median age was 66 (IQR: 55–76) years in CCUs and 74 (IQR: 57–85) years in HCUs. Age was the main risk factor of death in both CCUs and HCUs, with adjusted HRs (aHRs) in CCUs increasing from 1.60 (95% CI 1.35 to 1.88) for 46 to 65 years to 8.17 (95% CI 6.86 to 9.72) for ≥85 years. In HCUs, the aHR associated with age was more than two times higher. The gender was not significantly associated with death, aHR 1.03 (95% CI 0.98 to 1.09, p=0.2693) in CCUs. Most of the underlying chronic conditions were risk factors for death, including malignant neoplasm (CCU: 1.34 (95% CI 1.25 to 1.43); HCU: 1.41 (95% CI 1.35 to 1.47)), cirrhosis without transplant (1.41 (95% CI 1.22 to 1.64); 1.27 (95% CI 1.12 to 1.45)) and dementia (1.30 (95% CI 1.16 to 1.46); 1.07 (95% CI 1.03 to 1.12)).ConclusionThis analysis confirms the role of age as the major risk factor of death in patients with COVID-19 irrespective to admission to critical care and therefore supports the current vaccination policies targeting older individuals.
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Huang, Joanna C., Sudeep Karve, Sanchita Porwal, Kushan Thakkar, Thomas Marshall, and Tanja Rosenberg. "Health Care Utilization and Costs Among Patients with Chronic Myeloid Leukemia Using Tyrosine Kinase Inhibitors." Blood 132, Supplement 1 (November 29, 2018): 3537. http://dx.doi.org/10.1182/blood-2018-99-113809.

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Abstract INTRODUCTION: Tyrosine kinase inhibitors (TKIs) remain mainstay in the management of patients with CML. Several TKIs have been approved over the last two decades. Even though efficacy and safety remain as the primary drivers in treatment selection, in recent years importance has been placed on treatment affordability and economic burden associated with the long-term cancer treatments such as TKIs. However, current literature lacks real-world data on healthcare utilization (HCU) and costs among patients with CML using TKIs, which this study aims to address. METHODS: Retrospective cohort study was conducted using MarketScan Commercial, and Supplemental Medicare databases (2012-2016). Data includes medical and pharmacy utilization and costs for over 90 million individuals enrolled in employer-sponsored health-plans in the US. Data includes information on but not limited to medical diagnosis, procedures, drugs dispensed, date of service, health plan enrollment. Study involves adult patients (≥18 years) with ≥2 medical claims with a diagnosis of CML (ICD-9-CM: 205.10 - 205.12; ICD-10: C92.10-C92.12) and with a prescription claim for TKI. The date of first-TKI claim defined the index date. Patients were required to have continuous health plan enrollment ≥6 months before (defined as baseline period) and ≥6 months after index date. Selected patients were further classified into 5 sub-groups based on the index TKI observed (prescribed) post CML diagnosis (imatinib, dasatinib, nilotinib, bosutinib, ponatinib). Among the selected patients, all-cause HCU and costs were assessed from index date until end of database or end of enrollment, whichever occurred earlier. HCU and associated costs were assessed overall and by care settings including inpatient, emergency room, physician office, outpatient hospital, outpatient pharmacy, nursing facility and ancillary care. In addition, baseline (6 month) utilization and costs were assessed. Monthly and annual resource utilization and costs were reported for the overall CML cohort (across all TKI users) and by index TKI sub-groups. All costs were reported from a payer perspective (i.e., costs reimbursed by health plan) and adjusted to 2017 US dollars using the US consumer price index (medical component). All analyses were descriptive in nature. RESULTS: The study cohort included 2,213 CML patients. Distribution for the index TKI treatment was as follows: 41% imatinib, 36% dasatinib, 21% and 1% each for bosutinib and ponatinib. Mean age (standard deviation [SD]) of the cohort was 55 (15) years which was similar for individual TKI sub-groups. Majority of patients were males (55%) and 56% were enrolled in a preferred provider organization plan. The mean follow-up duration post-TKI initiation was 607 (442) days. The average baseline monthly all-cause costs were $4,365 with inpatient and pharmacy costs accounting for over 3/4th of the total costs (Figure 1). Post-TKI initiation the average monthly costs were twice ($9,288) compared with the baseline costs ($4,365) and the increase was primarily attributable to higher outpatient pharmacy costs ($6,619, accounted for 71% of total costs) (Figure 2). Monthly costs across other care settings (inpatient, outpatient, emergency room) were similar for the baseline and post-TKI initiation. On average patients had 1.4 office visits, 2.5 prescriptions and 0.7 hospital outpatient visits per month at baseline, which increased by 23%, 38% and 49%, respectively post TKI-initiation. During the 1st year post TKI-initiation, 17% patients in the overall CML cohort had at least 1 inpatient admission and this was consistent across individual TKI-sub-groups (except ponatinib, 50%). CONCLUSIONS: Findings on TKI utilization and costs in employer-sponsored health-plan database indicate that average costs and utilization were similar across the TKI sub-groups with pharmacy costs accounting for 71% of the total post TKI initiation costs. Overall, this study helps address the literature gap by providing recent real-world treatment care-setting specific utilization and costs among TKI uses and these data can be of value to several healthcare stakeholders including physicians, managed care plans and researchers in supporting clinical and formulary decisions and also serve as inputs for economic models. Finally, the sample sizes for ponatinib and bosutinb were small and results for these TKIs should be interpreted with caution. Disclosures Huang: ZS Associates: Employment; Novo Nordisk Inc: Equity Ownership; AstraZeneca: Research Funding. Karve:AbbVie: Employment, Equity Ownership. Porwal:ZS Associates: Employment. Thakkar:ZS Associates: Employment. Marshall:AbbVie: Employment, Equity Ownership. Rosenberg:AbbVie: Employment, Equity Ownership.
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Arnold, J. G., R. Srinivasan, T. S. Ramanarayanan, and M. DiLuzio. "Water resources of the Texas Gulf Basin." Water Science and Technology 39, no. 3 (February 1, 1999): 121–33. http://dx.doi.org/10.2166/wst.1999.0151.

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A geographic information system (GIS) has been integrated with a distributed parameter, continuous time, nonpoint source pollution model SWAT (Soil and Water Assessment Tool) for the management of water resources. This integration has proven to be effective and efficient for data collection and to visualize and analyze the input and output of simulation models. The SWAT-GIS system is being used to model the hydrology of eighteen major river systems in the United States (HUMUS). This paper focuses on the integration of SWAT (basin scale hydrologic model) with the Geographical Resources Analysis Support System (GRASS-GIS) and a relational database management system. The system is then applied to the Texas Gulf River basin. Input data layers (soils, land use, and elevation) were collected at a scale of 1:250,000 from various sources. Average monthly simulated and observed stream flow records from 1970-1979 are presented for the hydrologic cataloging units (HCU) defined by the United States Geological Survey (USGS) in the Texas Gulf basin. Average annual sediment yields computed from sediment rating curves are compared against simulated sediment yields from seven river basins within the Texas Gulf showing reasonable agreement.
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Sada, K. E., Y. Kojo, J. Fairburn-Beech, K. Sato, E. Hayashi, S. Akiyama, and M. Van-Dyke. "FRI0218 PREVALENCE, BURDEN OF DISEASE AND HEALTHCARE UTILIZATION AMONG PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) IN JAPAN 2005-2017." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 692.1–693. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1658.

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Background:EGPA is a rare vasculitis condition with very limited data available from real-world settings on burden and health care utilization (HCU), particularly in Japan.Objectives:To estimate the prevalence (overall and age, gender stratified) and describe HCU and treatment patterns among Japanese EGPA patients.Methods:This was a retrospective descriptive cohort study using a large administrative claims database covering up to more than 5 million corporate employees and their dependents (JMDC claim database) in Japan. Annual prevalence from 2005-2017 was estimated using two EGPA case definitions: a) patients with ≥1 ICD-10 code (2003 version) for EGPA (M30.1), b) patients with ≥2 ICD-10 codes for EGPA (M30.1) during the year in which prevalence was calculated. Among newly identified EGPA patients with no EGPA code in at least 12 months before, clinical burden, comorbidities, after hour visiting (AHV), all cause hospitalization, and treatment with drugs, including oral corticosteroid (OCS) use was described. OCS dose was expressed as prednisone equivalent.Results:The total number of newly identified patients in 2006-2016 was 45 persons and the mean (SD) age was 42.3 years (SD 14.7 years). The prevalence (per 1,000,000 patients) of EGPA with case definition a) in Japan in 2017 was estimated to be 38.0. The stratified prevalence (per 1,000,000) by age was: 2.3 in the group aged <18 years, 34.0 in those aged 18-50 years, and 91.1 in those aged ≥50 years, respectively. The prevalence in females (50.0) was approximately 1.7-fold higher than that in male (28.7). The prevalence, including stratified results, with definition b) was similar to that with definition a). In the newly identified patients, 60% of patients had at least one hospitalization and 55.6% had AHV, in the year after the first observed EGPA code during the study period. Following index date, new patients were treated: 77.8% with OCS, 11.1% with Azathioprine, 8.9% with intravenous immunoglobulin, 6.7% with Cyclophosphamide, 4.4% with Methotrexate, and 2.2% with Rituximab (non mutually exclusive). The mean (SD) maximum recorded daily dose of OCS in the 12 months follow up period was 53.5 (39.9) mg in new patients. The average dose (SD) of OCS in first month and last month in new patients was 39.1 (29.0) and 9.8 mg (4.8), respectively. Among those with at least a 14-day supply of OCS, 73.1% could be classified as adherent (≥80%) based on their 1-year proportion of days covered. 6.7% of EGPA patients experienced a potentially worsening with an increase of ≥10 mg daily OCS dose prescription following a previous prescription of <10mg.Conclusion:Analysis of the burden of disease and the use of medical resources in newly identified EGPA patients revealed that EGPA patients require hospitalizations and AHV, in addition to exposure to high doses of OCS. The appropriate medication for the treatment of EGPA to reduce burden on patients may need consider the pathophysiological state of EGPA patients.Disclosure of Interests:KEN-EI SADA Speakers bureau: I received speaker’s fee from GSK and Astra Zeneca K.K., Yoshiki Kojo Shareholder of: GSK, Employee of: GSK, Jolyon Fairburn-Beech Shareholder of: GSK, Employee of: GSK, Keiko Sato Shareholder of: GSK, Employee of: GSK, Etsuko Hayashi Shareholder of: GSK, Employee of: GSK, Shoko Akiyama Shareholder of: GSK, Employee of: GSK, melissa van-dyke Shareholder of: GSK, Employee of: GSK
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Gao, Yan, Yan Li, Ziyan Song, Zhenxing Jin, Xiao Li, and Chunluan Yuan. "Sortilin 1 Promotes Hepatocellular Carcinoma Cell Proliferation and Migration by Regulating Immune Cell Infiltration." Journal of Oncology 2022 (July 8, 2022): 1–13. http://dx.doi.org/10.1155/2022/6509028.

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Objectives. Recent evidence suggests that Sort1 promotes carcinogenesis and tumor progression in multiple types of cancers. This study investigates the role of Sort1 in hepatocellular carcinoma (HCC). Methods. The differentially expressed gene was screened through GEO and TCGA databases. The Sort1 gene was identified and its expression was then verified by TCGA and HCCDB (a database of hepatocellular carcinoma expression atlas) databases. The Human Protein Atlas database was used to assess the gene expression in tissues. The TCGA and KM-plotter databases were used to study the relationship between Sort1 and HCC. The correlation between Sort1 and immune cells was evaluated through the TIMER database. GO and KEGG enrichment analysis was used to investigate the possible mechanism. The role of Sort1 in cell proliferation and invasion of HCC was further explored through in vitro experiments. Result. The differentially expressed molecule obtained from database screening was Sort1. Its expression was higher in cancer tissues than in paracancerous ones, and it was mainly located in the cytoplasm. The TCGA, KM-plotter databases, and our study data showed that low expression of Sort1 in HCC patients had better overall survival (OS), progression-free survival (PFI), and disease-specific survival (DSS). Further analysis indicated a significant correlation between Sort1 expression and immune cell infiltration. The gene set enrichment analysis (GSEA) analysis showed that Sort1 affected the biological events of HCC by participating in the WNT, TGF-BETA, JAK, STAT, and CALCIUM signaling pathways. In vitro, cytological experiments demonstrated reduced expression of PCNA, Ki-67, Vimentin, N-cadherin, and MMP-9 mRNA after knocking down Sort1, although E-cadherin expression was promoted. Overall, these processes reduced the ability of proliferation and invasion of HCC cells. Conclusion. Downregulation of Sort1 can prolong the OS, PFI, and DSS of HCC patients. Furthermore, due to its link with immune cell infiltration, the Sort1 gene represents a potentially novel predictive biomarker of HCC. The growth of HCC can be significantly inhibited by interfering with Sort1; therefore, these results provide a potential target for developing anticancer strategies for HCC.
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Dissertations / Theses on the topic "HCU database"

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REA, FEDERICO. "Monitoring and assessing diagnostic-therapeutic paths with healthcare utilization databases: experiences, concerns and challenges." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/262324.

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The aim of this thesis is to provide the methodology used to develop and validate population-based prognostic scores, and to assess the effectiveness and cost-effectiveness of the diagnostic-therapeutic path of diabetes, using the healthcare utilization databases (or administrative databases) of Italian regions. Thus, the thesis is structured into the following three main parts. First, the reasons to justify the need of real-world studies in addition to evidence from randomized controlled trials, the definitions of real-world data and real-world evidence, and an overview of the Italian healthcare utilization databases are given. Second, because patients should be monitored according to their risk to experience adverse outcomes (e.g., all-cause mortality, hospital admissions), prognostic scores could be used. However, the main limitation in the use of pre-existing score is that they are usually developed in countries different from Italy and from hospital-based or pharmacy-based surveys, so hindering their applicability to all beneficiaries of the National Health Service. Therefore, two population-based prognostic scores were developed and validated using data from some Italian regions. The usefulness of one of these scores (i.e., the so-called Multisource Comorbidity Score) in the risk adjustments and as a tool for health policy planning is also shown. Third, tracing the work carried out from the “Monitoring and assessing care pathways” working group of the Italian Ministry of Health, a description of the following activities is provided: I. the development of process indicators to monitor and assess the quality of care of patients suffering from some chronic disease; II. the comparison of care quality between regions; III. the validation of the diabetes care indicators with respect to selected outcomes (i.e., the assessment of their effectiveness); IV. the assessment of the costs from the National Health Service perspective (calculated by the amount that the Regional Health Authority reimbursed to health providers) according to different levels of adherence to the diagnostic-therapeutic path of diabetes. Finally, the Beaver® regional research platform, able to compute the set of process and outcome indicators defined by the Health Ministry and to generate evidence on effectiveness and cost-effectiveness profile, is described.
The aim of this thesis is to provide the methodology used to develop and validate population-based prognostic scores, and to assess the effectiveness and cost-effectiveness of the diagnostic-therapeutic path of diabetes, using the healthcare utilization databases (or administrative databases) of Italian regions. Thus, the thesis is structured into the following three main parts. First, the reasons to justify the need of real-world studies in addition to evidence from randomized controlled trials, the definitions of real-world data and real-world evidence, and an overview of the Italian healthcare utilization databases are given. Second, because patients should be monitored according to their risk to experience adverse outcomes (e.g., all-cause mortality, hospital admissions), prognostic scores could be used. However, the main limitation in the use of pre-existing score is that they are usually developed in countries different from Italy and from hospital-based or pharmacy-based surveys, so hindering their applicability to all beneficiaries of the National Health Service. Therefore, two population-based prognostic scores were developed and validated using data from some Italian regions. The usefulness of one of these scores (i.e., the so-called Multisource Comorbidity Score) in the risk adjustments and as a tool for health policy planning is also shown. Third, tracing the work carried out from the “Monitoring and assessing care pathways” working group of the Italian Ministry of Health, a description of the following activities is provided: I. the development of process indicators to monitor and assess the quality of care of patients suffering from some chronic disease; II. the comparison of care quality between regions; III. the validation of the diabetes care indicators with respect to selected outcomes (i.e., the assessment of their effectiveness); IV. the assessment of the costs from the National Health Service perspective (calculated by the amount that the Regional Health Authority reimbursed to health providers) according to different levels of adherence to the diagnostic-therapeutic path of diabetes. Finally, the Beaver® regional research platform, able to compute the set of process and outcome indicators defined by the Health Ministry and to generate evidence on effectiveness and cost-effectiveness profile, is described.
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Conti, Laura. "HCI e Data Visualization per dati distribuiti geograficamente: un caso di studio." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15556/.

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Il caso di studio esaminato dalla tesi mette in pratica le ricerche e gli studi effettuati riguardanti le metodologie di Human Computer Interaction (HCI) e le tecniche di Data Visualization. Il sistema realizzato in termini di web app responsive permette la ricerca e la visualizzazione delle relazioni internazionali, intrattenute da professori e ricercatori dell'Università di Bologna. L'obiettivo è stato raggiunto partendo dall'analisi del primo prototipo già esistente del sistema, seguita dalla riprogettazione della struttura sottostante e dall'implementazione delle nuove specifiche concordate con il target user. Utilizzando gli strumenti appartenenti ad HCI e Data Visualization, il focus durante l'intera procedura di sviluppo è stato l'utente, definendo una progettazione User Centered che mette al primo posto i bisogni e le necessità di chi utilizza il sistema. Tra le funzionalità implementate si ricorda la possibilità di visualizzare le informazioni in base alla propria posizione, tramite l'utilizzo della geolocalizzazione che offre un servizio puntuale all'utente. Per ottenere una visualizzazione aggregata delle informazioni si sono utilizzati grafici e mappe di calore in pieno stile Data Visualization, usufruendo delle librerie JavaScript D3.js e Leaflet.js. Tra gli elementi tecnologici usati si ricorda il solution stack XAMPP, il framework CakePHP e i linguaggi di programmazione HTML, CSS, JavaScript, PHP e Python. Tali scelte sono state eseguite allo scopo di uniformare le tecnologie a quelle generalmente utilizzate all'interno dell'Ateneo, assicurando una più semplice manutenzione ed evoluzione futura.
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Falk, Joakim. "Usability guided development of a participant database system." Thesis, Linköpings universitet, Interaktiva och kognitiva system, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-146269.

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This project consisted of the development of a web based participant database system to replace a spreadsheet based one for the project “Vi Ses! Språkvänner i Linköping” and the evaluation of it. The design and implementation was done iteratively using a collection of usability guidelines as well as the results of a set of user tests. User tests were also used for the evaluation of the web database system. The task during the user tests was participant matching and the main measurement taken was task completion time. The project resulted in a web database system that could fully replace the spreadsheet database system. The evaluation tests showed that this system was both faster to match participants in as well as less error prone.
Detta projekt bestod av utvecklingen och evalueringen av ett webbaserat databassystem för deltagare. Den skulle ersätta ett existerande Excel-baserat databassystem för projektet “Vi Ses! Språkvänner i Linköping”. Designen och implementationen gjordes iterativt med hjälp av användbarhetsriktlinjer och resultat från användartester. Användartester användes även för evalueringen av webbdatabassystemet. Uppgiften i användartesterna var deltagarmatchning och det huvudsakliga mätvärdet var hur lång tid uppgiften tog. Projektet resulterade i ett webbaserat databassystem som helt kunde ersätta det Excel-baserade systemet. Evalueringstesterna visade att systemet var både snabbare och mindre felbenäget att matcha deltagare i.
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Saless, Neema. "Using HcB-8 and HcB-23 recombinant congenic mice to discover genes for bone strength." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Khawaja, Anas Ahmad. "Studie rozmanitosti HCV IRES: propojení experimentálního přístupu s přípravou a hodnocením rozsáhlé databáze mutací." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-351519.

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Translation initiation in the hepatitis C virus (HCV) occurs through a cap- independent mechanism that involves an internal ribosome entry site (IRES) capable of interaction with and utilization of the eukaryotic translational machinery. We focused on the structural configuration of the different HCV-IRES domains and the impact of IRES primary sequence variations on secondary structure conservation and function. For this purpose we introduced into our laboratory, methods such as denaturing gradient and temperature gradient gel electrophoresis for screening the degree of heterogeneity and total amount of HCV-IRES variability accumulated in HCV infected patients over a period of time. The selected samples showed variable migration pattern of the HCV-IRES (from all the patients) visualized in DGGE and TGGE, were sequenced and evaluated for translation efficiency using flow cytometry. In some cases, we discovered that multiple mutations, even those scattered across different domains of HCV-IRES, led to restoration of the HCV-IRES translational activity, although the individual occurrences of these mutations were found to be deleterious. We propose that such observation may be attributed to probable long- range inter- and/or intra-domain functional interactions. We established a large-scale HCV-IRES...
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Chin, Pei-Ju, and 勤沛儒. "The Single Nucleotide Polymorphism Database of HCR Gene in Taiwanese Patients With Psoriasis." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/76720755799667527970.

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碩士
國立陽明大學
遺傳學研究所
90
Psoriasis is a chronic skin disorder occurring in 1%~2% of dermatosis cases. There is no difference between male and female for the frequency of psoriasis. Characteristic features include epidermal keratinocyte hyperproliferation, altered epidermal maturation, vascular proliferation, and inflammatory cell accumulation. Whereas the pathogenesis of psoriasis remains uncertain, some evidence suggest that multiple factors, including environmental stress, virus, microbe, autoimmune system can cause psoriasis synergistically. Although the genetic component of psoriasis is still unknown, modern genetic analysis suggest the transmission of psoriasis is affected by genetic factors. Previous studies suggest that the psoriasis and genetic factors are highly correlated. The psoriasis candidate loci have been narrowed down by applying improve on genetic assay methods. One of the candidate locus contains immune gene cluster, called HLA-C cluster or PSOR1, which locates on the chromosome 6p. This locus is one of the highly polymorphic gene clusters ever known. Recent studies indicate that one of the PSOR1 genes, called HCR, correlates with the pathogenesis of psoriasis. The distribution of single nucleotide polymorphisms (SNP) in HCR will affect the frequency of psoriasis. Using the genomic DNA sequencing and dHPLC, screen of the SNPs in HCR gene of Taiwanese patients with psoriasis. By the case-control study we find some significant SNPs have higher allele frequency in patients than in healthy controls. Furthermore, some SNPs alter the amino acid sequence of the HCR protein. Wishing genetic epidemiology and functional studies, these SNPs will provide some clues to understanding the pathogeny of psoriasis. The other purpose in our research is to establish a SNP database of pathogenic genes in Taiwanese patients. At the beginning, data of SNPs in HCR genes isused to generate the prototype of this database. We create a lot of functional modules to fit the requirement of personal medical care and other practical applications. In the future, expansion and improvement of the database is necessary increase to a capacity for more and more SNPs discovery. Combination of the wet-bench experiences and bioinformatics techniques, we give an example for large-scale SNP data analysis and friendly query system for the research of pathogenic SNP screen.
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Ringeisen, Bradley Richard. "Collisions and reactions of HCl and HBr with liquid glycerol." 2000. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Feketová, Zuzana. "S čepičkou nebo bez čepičky? Iniciace translace eukaryot se zaměřením na opurtunního patogena C. albicans." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311436.

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Candida albicans belongs to serious human opportunistic pathogens, causing severe health complications to immunocompromised patients. To my best knowledge, it is the only organism that survives with unmethylated cap structures found on the 5'ends of mRNA molecules. Using functional assay, I demonstrated that orf19.7626 codes for C. albicans translation initiation factor 4E (Ca4E). We couldn't prove our hypothesis, that Ca4E could be responsible for the unmethylated cap recognition in our model organism S. cerevisiae. Candida sp. possesses also another rather unusual feature - ambiguous CUG codon. In most of the cases, CUG is decoded as a serine, but sometimes also as a leucine. This gives rise to a so called "statistical proteome". One CUG codon is also part of the mRNA coding for Ca4E protein, therefore two versions of Ca4E-Ca4ELeu and Ca4ESer -might occur in C. albicans simultaneously. Both of them are able to rescue deletion of S. cerevisiae eIF4E gene, but they confer temperature sensitivity to the heterologous host. This phenotype is more pronounced with the Ca4ELeu version. We observed milder temperature sensitive phenotype after co-expression of Ca4E together with C. albicans eIF4G (Ca4G). Conformational coupling between eIF4E and eIF4G leads to enhanced affinity of eIF4E to the cap...
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Books on the topic "HCU database"

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Dirgahayu, Paramasari. Molecular epidemiology database of HIV, HBV, HCV, HDV, HTLV-1/2, and TTV in Central of Java, Indonesia: Final report international research collaboration and international publication. [Surakarta]: Sebelas Maret Univ., 2010.

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Gavriel, Salvendy, and SpringerLink (Online service), eds. Human Interface and the Management of Information. Designing Information Environments: Symposium on Human Interface 2009, Held as Part of HCI International 2009, San Diego, CA, USA, July 19-24, 2009, Procceedings, Part I. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009.

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Smith, Michael J. Human Interface and the Management of Information. Interacting with Information: Symposium on Human Interface 2011, Held as Part of HCI International 2011, Orlando, FL, USA, July 9-14, 2011, Proceedings, Part I. Berlin, Heidelberg: Springer-Verlag GmbH Berlin Heidelberg, 2011.

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Schmorrow, Dylan D. Foundations of Augmented Cognition. Directing the Future of Adaptive Systems: 6th International Conference, FAC 2011, Held as Part of HCI International 2011, Orlando, FL, USA, July 9-14, 2011. Proceedings. Berlin, Heidelberg: Springer-Verlag GmbH Berlin Heidelberg, 2011.

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Holzinger, Andreas. Human-Computer Interaction and Knowledge Discovery in Complex, Unstructured, Big Data: Third International Workshop, HCI-KDD 2013, Held at SouthCHI 2013, Maribor, Slovenia, July 1-3, 2013. Proceedings. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013.

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R, Meersman, Tari Zahir, and HCI-SWWA (2003 : Catania, Sicily), eds. On the move to meaningful Internet systems 2003: OTM 2003 workshops : OTM confederated international workshops : HCI-SWWA, IPW, JTRES, WORM, WMS, and WSRM 2003, Catania, Sicily, November 3-7, 2003 : proceedings. New York: Springer-Verlag, 2003.

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Salvendy, Gavriel, and Michael J. Smith. Human Interface and the Management of Information. Interacting with Information: Symposium on Human Interface 2011, Held as Part of HCI International ... FL, USA, July 9-14, 2011. Proceedings, Part I. Springer, 2011.

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Schmorrow, Dylan D., and Cali M. Fidopiastis. Foundations of Augmented Cognition. Directing the Future of Adaptive Systems: 6th International Conference, FAC 2011, Held as Part of HCI ... FL, USA, July 9-14, 2011, Proceedings. Springer, 2011.

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Book chapters on the topic "HCU database"

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Draper, Stephen W. "HCI and Database work: Reciprocal relevance and challenges." In Workshops in Computing, 455–65. London: Springer London, 1993. http://dx.doi.org/10.1007/978-1-4471-3423-7_25.

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Lin, Rungtai, Ricer Cheng, and Ming-Xian Sun. "Digital Archive Database for Cultural Product Design." In Usability and Internationalization. HCI and Culture, 154–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-73287-7_20.

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Salman, Ahmad Ali, and Shiny Verghese. "Database Design for Online Psychometric Design (OnPsyD) Tool." In HCI International 2014 - Posters’ Extended Abstracts, 234–39. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07857-1_42.

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Kaltenthaler, Daniel, Johannes-Y. Lohrer, Peer Kröger, and Henriette Obermaier. "xBook, a Framework for Common Scientific Databases." In HCI International 2018 – Posters' Extended Abstracts, 62–70. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92270-6_9.

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Yaish, Haitham, Madhu Goyal, and George Feuerlicht. "Proxy Service for Multi-tenant Database Access." In Availability, Reliability, and Security in Information Systems and HCI, 100–117. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40511-2_8.

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Terauchi, Mina, Keiko Watanabe, Yuji Nagashima, Naoto Kato, Taro Miyazaki, Seiki Inoue, Shuichi Umeda, Toshihiro Shimizu, and Nobuyuki Hiruma. "Compilation of a Sign Language Database for Use in Medical Practice." In HCI International 2014 - Posters’ Extended Abstracts, 264–69. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07854-0_47.

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Barcelona, Antonio. "Chapter 1. General description of the metonymy database in the Córdoba project, with particular attention to the issues of hierarchy, prototypicality, and taxonomic domains." In Human Cognitive Processing, 27–54. Amsterdam: John Benjamins Publishing Company, 2018. http://dx.doi.org/10.1075/hcp.60.01bar.

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Rashid, Fatema, and Ali Miri. "An Emerging Strategy for Privacy Preserving Databases: Differential Privacy." In HCI for Cybersecurity, Privacy and Trust, 487–98. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50309-3_32.

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Hernández-Gomariz, Isabel. "Chapter 3. Analysis of metonymic triggers, metonymic chaining, and patterns of interaction with metaphor and with other metonymies as part of the metonymy database in the Córdoba project." In Human Cognitive Processing, 75–94. Amsterdam: John Benjamins Publishing Company, 2018. http://dx.doi.org/10.1075/hcp.60.03her.

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Leung, Carson K., Christopher L. Carmichael, Yaroslav Hayduk, Fan Jiang, Vadim V. Kononov, and Adam G. M. Pazdor. "Data Mining Meets HCI: Data and Visual Analytics of Frequent Patterns." In Machine Learning and Knowledge Discovery in Databases, 289–93. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46131-1_37.

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Conference papers on the topic "HCU database"

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Blatman, Géraud, Jean-Christophe Le Roux, Kim Wallin, Jussi Solin, Thomas Métais, Ertugrul Karabaki, and Wolfgang Mayinger. "Statistical Methods and Database Splitting for HCF Data Analysis." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63141.

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Fatigue curves are receiving nowadays an increased level of attention in the wake of experimental campaigns showing that the original ASME III mean air curve, also known as the Langer curve [1], does not represent accurately part of the recently obtained laboratory data. EDF, VTT and E.ON have been working towards a relevant fatigue assessment strategy. The three organizations recently exchanged HCF databases, providing a common benchmark to test and compare the various analysis methods. Following the 2014 PVP paper [2], several statistical approaches are being investigated. A special focus is given to methods able to properly account for run-out data points, which do not have the same statistical significance as failed data points. Besides, it has to be noted that only a limited number of material grades are used in NPP primary loop components and in each case, the material batches are identified and specified in detail. Therefore, a more accurate and relevant fatigue assessment might be obtained by splitting large datasets that generally mix various testing conditions and material grades. A comparison is made between a “mixed” approach and a “separated” one, in which the fatigue assessment is performed successively for two or more subsets, e.g. associated with two testing temperature ranges and/or steel grades. Both “mixed” and “separated” strategies are applied to the EDF and the E.ON databases containing fatigue data in different temperatures for non-stabilized and stabilized austenitic stainless steels. The resulting data scatters are compared and the significance of these statistical approaches to fatigue assessment is discussed.
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Mearaj, Insha, Piyush Maheshwari, and Maninder Jeet Kaur. "Data Conversion from Traditional Relational Database to MongoDB using XAMPP and NoSQL." In 2018 Fifth HCT Information Technology Trends (ITT). IEEE, 2018. http://dx.doi.org/10.1109/ctit.2018.8649513.

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Zhao, Yani, and Yongfang Xie. "Study on Differential Expression Genes in HCC Based on GEO Database." In BIC 2021: 2021 International Conference on Bioinformatics and Intelligent Computing. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3448748.3448759.

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Harris, Steven D., and Robert A. North. "Mining MAUDE: Human Factors Perspectives on EHR and Device Design From the FDA Manufacturers and Users Device Experience Database." In 2012 Symposium on Human Factors and Ergonomics in Health Care. Human Factors and Ergonomics Society, 2012. http://dx.doi.org/10.1518/hcs-2012.945289401.022.

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"Investigation of Strut Strength Using a Deep-Beam Database." In SP-265: Thomas T.C. Hsu Symposium: Shear and Torsion in Concrete Structures. American Concrete Institute, 2009. http://dx.doi.org/10.14359/51663305.

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Schopf, T., S. Weihe, and J. Rudolph. "Investigations on Multi-Stage Tests and Transient Endurance Limit Behavior Under Low-, High- and Very High Cycle Fatigue Loads." In ASME 2022 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/pvp2022-84718.

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Abstract The fatigue analyses included in nuclear rules of KTA [1]–[2] and ASME [3] are based on defined loads (specified or measured loads and frequencies). It is assumed that highly cyclic loadings or resonance vibrations are avoided by appropriate design. Often these loads are recorded by measurements during commissioning or during operation. In particular, in pressure vessel and reactor internals such vibrational excitations cannot be excluded, so that fatigue loadings in the HCF regime and even in the VHCF regime can occur. Since these kinds of loading situations also appear in combination with fatigue loadings in the LCF regime, load collectives are to be considered, as they are not explicitly taken into account in the current analysis of the nuclear regulations. Furthermore, no generally validated method, especially a consolidated damage accumulation model is available. Furthermore, design fatigue curves for austenitic steels in the applicable international design codes were extended by extrapolation from originally 106 up to 1011 load cycles [1]–[3]. However, the existing database for load cycles equal to or above 107 is still insufficient. Therefore, international efforts are currently ongoing in order to expand the database through international co-operations and compile a safe high cycle fatigue (HCF) database [4]. This is particularly important in combination with the influence of the cooling medium and its consideration according to established international standards as the database of the Argonne National Laboratory ANL [5] for fatigue behavior under medium conditions. For the range from HCF to VHCF and for their combination with LCF loads (collective effect) and the currently discussed limit values above which the cooling medium has an effective influence on the fatigue strength are not sufficiently consolidated. These aspects gain in importance particularly in the long-term operation context. A recently finished cooperative research project aims at contributing to closing these mentioned gaps by generation of a data and assessment basis for the fatigue behavior of welded austenitic stainless steels at high numbers of load cycles [6]. The following topics will be discussed in detail in the paper: • Fatigue behavior at variable amplitude loading (combination of LCF / HCF and LCF / VHCF) • Development of a fatigue assessment methodology under consideration of the transient endurance limit and damage accumulation effects including assessment and adaptation of appropriate fatigue damage parameters
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Lin, Chen, Wayne Mak, Pengyu Hong, Katharine Sepp, and Norbert Perrimon. "Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases." In 7th IEEE International Conference on Bioinformatics and Bioengineering. IEEE, 2007. http://dx.doi.org/10.1109/bibe.2007.4375742.

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Kim, Ji-Hoon, Seunghee Han, Kwanghyun Park, Soo-Young Ji, and Joo-Young Kim. "Trinity: End-to-End In-Database Near-Data Machine Learning Acceleration Platform for Advanced Data Analytics." In 2022 IEEE Hot Chips 34 Symposium (HCS). IEEE, 2022. http://dx.doi.org/10.1109/hcs55958.2022.9895601.

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Bychenko, Artem, Maksym Udovenko, Vitalii Nuianzin, and Andriy Berezovskyi. "Remote Visual Information System for Identification of Dangerous Substances Using Unmanned Aircrafts." In International Scientific Applied Conference "Problems of Emergency Situations". Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-i5mfl9.

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Development of a functional model of the process of creating a knowledge base on the recognition of objects and actions of the enemy on the basis of neural networks and fuzzy logic. The aim of the work is to develop a set of software and hardware designed for remote identification of hazardous substances by machine visual recognition of information signs of dangerous goods with the output of relevant information to the means of visual display (interface). Recommendations concerning providing UAVs with the necessary technical means to monitor the zone of emergencies are analyzed. The recommendations of the organization of radio communication between the UAV and the operator depending on the range of the UAV departure, terrain conditions etc are analyzed and given. The structural scheme of the complex of remote recognition of HC in the form of blocks, units and software and hardware is developed. As a result of the analysis of programming systems, it was found that Python programming language is the best choice to ensure the full operation of the software due to the built-in capabilities and the involvement of third-party frameworks. A database containing information on more than 3.000 HCs with detailed recommendations for emergency response is developed. The hardware and software complex for remote identification of dangerous substances by machine visual recognition of information signs of dangerous goods by UAV, consisting of unmanned aerial platform with photo-video recording means, data transmission system to ground control station, PC for processing results and related software are substantiated and developed. A test of the UAV's capabilities in recognizing danger signs with UN numbers in different lighting conditions was tested. In all cases, the HC was accurately identified. The ideas and methods proposed in this article will allow to create cheap and simple tools for rescue units of Ukraine, which deal with the consequences of emergencies related to the leakage of HCs.
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Santos, Túlio Silveira, and Paulo Cezar Martins Ribeiro. "Performance analysis of Brazilian highways under concession through the capacity and level of service." In CIT2016. Congreso de Ingeniería del Transporte. Valencia: Universitat Politècnica València, 2016. http://dx.doi.org/10.4995/cit2016.2016.3514.

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This paper proposes the development of a methodology to analyze the performance of highways under concession through the capacity and level of service, with special attention to Brazilian highways. The trajectory of transport infrastructure provision in Brazil and its performance assessment framework are mentioned, as well as an approach of the level of service concept and the Highway Capacity Manual (HCM). An inventory of the highway with the necessary data to the model is proposed. This database should incorporate information from multiple data sources and its use will be important for the processing and compilation of raw data in order to structure a full informational basis. Then, it is developed a method for segmentation of homogeneous road sections, as conceptualized by HCM, and proposed a way of level of service measurement. Finally, there are analysis of the use of HCM in some highways concession programs in Brazil.DOI: http://dx.doi.org/10.4995/CIT2016.2016.3514
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Reports on the topic "HCU database"

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Jin, Hongyu, and Man Zhang. LR-5 by LI-RADS under contrast enhanced ultrasonography manifests satisfactory diagnostic performance for hepatocellular carcinoma: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0011.

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Review question / Objective: To evaluate the relative diagnostic sensitivity, specificity, and accuracy of LR-5 under contrast-enhanced ultrasonography (CEUS) LI-RADS system in the differential diagnosis of hepatocellular carcinoma (HCC). Information sources: A comprehensive and thorough search of literature was carried out through internationally acknowledged medical literature resources database, including PubMed/MEDLINE, EMBASE, Ovid, and Web of Science along with regional databases with key research words of (“hepatocellular carcinoma” OR “liver cancer” OR “liver tumor” OR “liver nodule” OR “liver mass” OR “liver lesion”) AND (“contrast-enhanced US” OR “contrast-enhanced ultrasonography” OR “contrast-enhanced ultrasound” OR “CEUS”) AND (“LI-RADS” OR “liver reporting and data system”) for studies published between January 2017 and June 2021. We limited the language used in the literature as English only.
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Hung, Hsuan-Yu, and Chung-Yu Chen. The impact of Sofosbuvir/Velpatasvir/Voxilaprevir treatment on serum hyperglycemia in HCV infections: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0109.

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Review question / Objective: To assess the possible cause of events, the incidence of grade 3 hyperglycemia after treating Sofosbuvir/Velpatasvir/Voxilaprevir in HCV infections. Condition being studied: Sofosbuvir, velpatasvir, and voxilaprevir (SOF/VEL/VOX) is an effective, safe rescue therapy regimen for patients have previously been treated failure. Initiating Direct-Acting Antiviral (DAA) treatment for HCV infection with diabetes have experienced hypoglycemia, it could improve insulin resistance due to clean HCV. However, some studies shown that SOF/VEL/VOX has Grade 3 hyperglycemia adverse events. This finding contradicts that other DAAs studies. Information sources: Conducting a comprehensive literature search on the pubmed, Cochrane, clinicalkey, Embase, and MEDLINE electronic databases.
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Or, Etti, David Galbraith, and Anne Fennell. Exploring mechanisms involved in grape bud dormancy: Large-scale analysis of expression reprogramming following controlled dormancy induction and dormancy release. United States Department of Agriculture, December 2002. http://dx.doi.org/10.32747/2002.7587232.bard.

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The timing of dormancy induction and release is very important to the economic production of table grape. Advances in manipulation of dormancy induction and dormancy release are dependent on the establishment of a comprehensive understanding of biological mechanisms involved in bud dormancy. To gain insight into these mechanisms we initiated the research that had two main objectives: A. Analyzing the expression profiles of large subsets of genes, following controlled dormancy induction and dormancy release, and assessing the role of known metabolic pathways, known regulatory genes and novel sequences involved in these processes B. Comparing expression profiles following the perception of various artificial as well as natural signals known to induce dormancy release, and searching for gene showing similar expression patterns, as candidates for further study of pathways having potential to play a central role in dormancy release. We first created targeted EST collections from V. vinifera and V. riparia mature buds. Clones were randomly selected from cDNA libraries prepared following controlled dormancy release and controlled dormancy induction and from respective controls. The entire collection (7920 vinifera and 1194 riparia clones) was sequenced and subjected to bioinformatics analysis, including clustering, annotations and GO classifications. PCR products from the entire collection were used for printing of cDNA microarrays. Bud tissue in general, and the dormant bud in particular, are under-represented within the grape EST database. Accordingly, 59% of the our vinifera EST collection, composed of 5516 unigenes, are not included within the current Vitis TIGR collection and about 22% of these transcripts bear no resemblance to any known plant transcript, corroborating the current need for our targeted EST collection and the bud specific cDNA array. Analysis of the V. riparia sequences yielded 814 unigenes, of which 140 are unique (keilin et al., manuscript, Appendix B). Results from computational expression profiling of the vinifera collection suggest that oxidative stress, calcium signaling, intracellular vesicle trafficking and anaerobic mode of carbohydrate metabolism play a role in the regulation and execution of grape-bud dormancy release. A comprehensive analysis confirmed the induction of transcription from several calcium–signaling related genes following HC treatment, and detected an inhibiting effect of calcium channel blocker and calcium chelator on HC-induced and chilling-induced bud break. It also detected the existence of HC-induced and calcium dependent protein phosphorylation activity. These data suggest, for the first time, that calcium signaling is involved in the mechanism of dormancy release (Pang et al., in preparation). We compared the effects of heat shock (HS) to those detected in buds following HC application and found that HS lead to earlier and higher bud break. We also demonstrated similar temporary reduction in catalase expression and temporary induction of ascorbate peroxidase, glutathione reductase, thioredoxin and glutathione S transferase expression following both treatments. These findings further support the assumption that temporary oxidative stress is part of the mechanism leading to bud break. The temporary induction of sucrose syntase, pyruvate decarboxylase and alcohol dehydrogenase indicate that temporary respiratory stress is developed and suggest that mitochondrial function may be of central importance for that mechanism. These finding, suggesting triggering of identical mechanisms by HS and HC, justified the comparison of expression profiles of HC and HS treated buds, as a tool for the identification of pathways with a central role in dormancy release (Halaly et al., in preparation). RNA samples from buds treated with HS, HC and water were hybridized with the cDNA arrays in an interconnected loop design. Differentially expressed genes from the were selected using R-language package from Bioconductor project called LIMMA and clones showing a significant change following both HS and HC treatments, compared to control, were selected for further analysis. A total of 1541 clones show significant induction, of which 37% have no hit or unknown function and the rest represent 661 genes with identified function. Similarly, out of 1452 clones showing significant reduction, only 53% of the clones have identified function and they represent 573 genes. The 661 induced genes are involved in 445 different molecular functions. About 90% of those functions were classified to 20 categories based on careful survey of the literature. Among other things, it appears that carbohydrate metabolism and mitochondrial function may be of central importance in the mechanism of dormancy release and studies in this direction are ongoing. Analysis of the reduced function is ongoing (Appendix A). A second set of hybridizations was carried out with RNA samples from buds exposed to short photoperiod, leading to induction of bud dormancy, and long photoperiod treatment, as control. Analysis indicated that 42 genes were significant difference between LD and SD and 11 of these were unique.
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