Relevant bibliographies by topics / HCSCR

Academic literature on the topic 'HCSCR'

Author: Grafiati
Published: 11 March 2023

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Journal articles on the topic "HCSCR"

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Arsalan, Mani, Felix Woitek, Volker Adams, Axel Linke, Markus J. Barten, Stefan Dhein, Thomas Walther, Friedrich-Wilhelm Mohr, and Jens Garbade. "Distribution of Cardiac Stem Cells in the Human Heart." ISRN Cardiology 2012 (March 4, 2012): 1–5. http://dx.doi.org/10.5402/2012/483407.

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Introduction. The existence of human cardiac stem cells (hCSC) and their regenerative capacity are not fully defined. The aim of this study was to identify and analyse the distribution of hCSCs by flow cytometry (FCM). Methods. Tissue samples from the left ventricle (LV) and the appendages of the right atrium (RA) and left atrium (LA) were taken during cardiac surgery. Mononuclear cells (MNCs) were isolated, labelled for the stem-cell-marker c-kit and hematopoietic-lineage markers and analysed by FCM. Results. HCSCs could be isolated from the RA, LA, and LV without significant quantitative difference between both atria (A) (RA 4.80 ± 1.76% versus LA 4.99 ± 1.69% of isolated MNCs, P=0.922). The number of hCSCs was significantly higher in both atria compared to the left ventricle (A 4.90 ± 1.29% versus LV 0.62 ± 0.14% of isolated MNCs, P=0.035). Conclusion. The atria contain a higher concentration of hCSC than the left ventricle. HCSCs located in the atria could serve as an endogenous source for heart regeneration.
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Friday, Derek, David A. Savage, Steven A. Melnyk, Norma Harrison, Suzanne Ryan, and Heidi Wechtler. "A collaborative approach to maintaining optimal inventory and mitigating stockout risks during a pandemic: capabilities for enabling health-care supply chain resilience." Journal of Humanitarian Logistics and Supply Chain Management 11, no. 2 (February 22, 2021): 248–71. http://dx.doi.org/10.1108/jhlscm-07-2020-0061.

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PurposeInventory management systems in health-care supply chains (HCSC) have been pushed to breaking point by the COVID-19 pandemic. Unanticipated demand shocks due to stockpiling of medical supplies caused stockouts, and the stockouts triggered systematic supply chain (SC) disruptions inconceivable for risk managers working individually with limited information about the pandemic. The purpose of this paper is to respond to calls from the United Nations (UN) and World Health Organization (WHO) for coordinated global action by proposing a research agenda based on a review of current knowledge and knowledge gaps on the role of collaboration in HCSCs in maintaining optimal stock levels and reinforcing resilience against stockout disruptions during pandemics.Design/methodology/approachA systematic review was conducted, and a total of 752 articles were analyzed.FindingsCollaborative planning, forecasting and replenishment practices are under-researched in the HCSC literature. Similarly, a fragmented application of extant SC collaborative risk management capabilities undermines efforts to enhance resilience against systematic disruptions from medical stockouts. The paucity of HCSC articles in humanitarian logistics and SC journals indicates a need for more research interlinking two interdependent yet critical fields in responding to pandemics.Research limitations/implicationsAlthough based on an exhaustive search of academic articles addressing HCSCs, there is a possibility of having overlooked other studies due to search variations in language controls, differences in publication cycle time and database search engines.Originality/valueThe paper relies on COVID-19's uniqueness to highlight the limitations in optimization and individualistic approaches to managing medical inventory and stockout risks in HCSCs. The paper proposes a shift from a fragmented to holistic application of relevant collaboration practices and capabilities to enhance the resilience of HCSCs against stockout ripple effects during future pandemics. The study propositions and suggestion for an SC learning curve provide an interdisciplinary research agenda to trigger early preparation of a coordinated HCSC and humanitarian logistics response to future pandemics.
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Park, Ji Hye, Hyeok Kim, Hyung Ryong Moon, Bong-Woo Park, Jae-Hyun Park, Woo-Sup Sim, Jin-Ju Kim, et al. "Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair." Experimental & Molecular Medicine 53, no. 9 (September 2021): 1423–36. http://dx.doi.org/10.1038/s12276-021-00676-x.

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AbstractStem cell-based therapies with clinical applications require millions of cells. Therefore, repeated subculture is essential for cellular expansion, which is often complicated by replicative senescence. Cellular senescence contributes to reduced stem cell regenerative potential as it inhibits stem cell proliferation and differentiation as well as the activation of the senescence-associated secretory phenotype (SASP). In this study, we employed MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation. In vitro experiments showed that the MHY-1685‒primed hCSCs exhibited higher viability in response to oxidative stress and an enhanced proliferation potential compared to that of the unprimed senile hCSCs. Interestingly, priming MHY-1685 enhanced the expression of stemness-related markers in senile hCSCs and provided the differentiation potential of hCSCs into vascular lineages. In vivo experiment with echocardiography showed that transplantation of MHY-1685‒primed hCSCs improved cardiac function than that of the unprimed senile hCSCs at 4 weeks post-MI. In addition, hearts transplanted with MHY-1685-primed hCSCs exhibited significantly lower cardiac fibrosis and higher capillary density than that of the unprimed senile hCSCs. In confocal fluorescence imaging, MHY-1685‒primed hCSCs survived for longer durations than that of the unprimed senile hCSCs and had a higher potential to differentiate into endothelial cells (ECs) within the infarcted hearts. These findings suggest that MHY-1685 can rejuvenate senile hCSCs by modulating autophagy and that as a senescence inhibitor, MHY-1685 can provide opportunities to improve hCSC-based myocardial regeneration.
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Mazzone, Paolo, Fabio Viselli, Stefano Ferraina, Margherita Giamundo, Massimo Marano, Marco Paoloni, Francesco Masedu, Annamaria Capozzo, and Eugenio Scarnati. "High Cervical Spinal Cord Stimulation: A One Year Follow-Up Study on Motor and Non-Motor Functions in Parkinson’s Disease." Brain Sciences 9, no. 4 (April 3, 2019): 78. http://dx.doi.org/10.3390/brainsci9040078.

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Background: The present study investigated the effectiveness of stimulation applied at cervical levels on pain and Parkinson’s disease (PD) symptoms using either tonic or burst stimulation mode. Methods: Tonic high cervical spinal cord stimulation (T-HCSCS) was applied on six PD patients suffering from low back pain and failed back surgery syndrome, while burst HCSCS (B-HCSCS) was applied in twelve PD patients to treat primarily motor deficits. Stimulation was applied percutaneously with quadripolar or octapolar electrodes. Clinical evaluation was assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Hoehn and Yahr (H&Y) scale. Pain was evaluated by a visual analog scale. Evaluations of gait and of performance in a cognitive motor task were performed in some patients subjected to B-HCSCS. One patient who also suffered from severe autonomic cardiovascular dysfunction was investigated to evaluate the effectiveness of B-HCSCS on autonomic functions. Results: B-HCSCS was more effective and had more consistent effects than T-HCSCS in reducing pain. In addition, B-HCSCS improved UPDRS scores, including motor sub-items and tremor and H&Y score. Motor benefits appeared quickly after the beginning of B-HCSCS, in contrast to long latency improvements induced by T-HCSCS. A slight decrease of effectiveness was observed 12 months after implantation. B-HCSCS also improved gait and ability of patients to correctly perform a cognitive–motor task requiring inhibition of a prepared movement. Finally, B-HCSCS ameliorated autonomic control in the investigated patient. Conclusions: The results support a better usefulness of B-HCSCS compared to T-HCSCS in controlling pain and specific aspects of PD motor and non-motor deficits for at least one year.
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Kim, Sung-A., Akira Babazono, Aziz Jamal, Yunfei Li, and Ning Liu. "Comparison of care utilisation and medical institutional death among older adults by home care facility type: a retrospective cohort study in Fukuoka, Japan." BMJ Open 11, no. 4 (April 2021): e041964. http://dx.doi.org/10.1136/bmjopen-2020-041964.

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ObjectivesWe compared the care services use and medical institutional deaths among older adults across four home care facility types.DesignThis was a retrospective cohort study.SettingWe used administrative claims data from April 2014 to March 2017.ParticipantsWe included 18 347 residents of Fukuoka Prefecture, Japan, who received home care during the period, and aged ≥75 years with certified care needs of at least level 3. Participants were categorised based on home care facility use (ie, general clinics, Home Care Support Clinics/Hospitals (HCSCs), enhanced HCSCs with beds and enhanced HCSCs without beds).Primary and secondary outcome measuresWe used generalised linear models (GLMs) to estimate care utilisation and the incidence of medical institutional death, as well as the potential influence of sex, age, care needs level and Charlson comorbidity index as risk factors.ResultsThe results of GLMs showed the inpatient days were 54.3, 69.9, 64.7 and 75.0 for users of enhanced HCSCs with beds, enhanced HCSCs without beds, HCSCs and general clinics, respectively. Correspondingly, the numbers of home care days were 63.8, 51.0, 57.8 and 29.0. Our multivariable logistic regression model estimated medical institutional death rate among participants who died during the study period (n=9919) was 2.32 times higher (p<0.001) for general clinic users than enhanced HCSCs with beds users (relative risks=1.69, p<0.001).ConclusionsParticipants who used enhanced HCSCs with beds had a relatively low inpatient utilisation, medical institutional deaths, and a high utilisation of home care and home-based end-of-life care. Findings suggest enhanced HCSCs with beds could reduce hospitalisation days and medical institutional deaths. Our study warrants further investigations of home care as part of community-based integrated care.
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Chen, Changfu, Yongxia Han, Junxiang Liu, Wenxiong Mo, Zhao Yuan, Jianning Huang, Haibo Su, Xiancong Zhang, and Kaijian Wu. "Research on the Lightning Intruding Overvoltage and Protection Measures of 500 kV AC Fault Current Limiter." Energies 12, no. 20 (October 11, 2019): 3845. http://dx.doi.org/10.3390/en12203845.

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As one of the key technologies to solve the problem of high short-circuit current, the fault current limiter (FCL) has become a research hotspot in China and abroad. The overvoltage and protection measures of the FCL are the key technologies for its application. Therefore, this paper studies the lightning intruding overvoltage and protection measures for a 500 kV FCL based on a high coupled split reactor (HCSR). Firstly, according to the main topology of the system and the 500 kV HCSR-FCL structure, the lightning intruding overvoltage simulation model of the 500 kV station, including the nearby transmission lines, is established on the PSCAD (Power Systems Computer Aided Design) program. Secondly, the lightning overvoltage of the equipment in the station and the components of the HCSR-FCL are simulated and analyzed when the transmission lines nearby are subjected to lightning shielding failure and back flashover. Meanwhile, the influence of the HCSR-FCL on the lightning overvoltage of the equipment in the station are compared and analyzed before and after the HCSR-FCL is installed. The simulation results show that the overvoltage of the equipment in the station and the components of the HCSR-FCL is more serious when the shielding failure occurs in the transmission lines nearby. The HCSR-FCL can reduce the lightning overvoltage of the equipment in the station, but the maximum inter-terminal and inter-arm lightning overvoltage of the HCSR can reach 1064 kV and 790 kV, respectively, under the current limiting state and the current sharing state. Finally, methods of increasing the arresters on the transmission lines side of the HCSR-FCL and shunt capacitor between each module of the HCSR-FCL are proposed to reduce the lightning overvoltage. The lightning impulse withstand voltage of each component of the HCSR is also proposed: The inter-terminal lightning impulse withstand voltage of HCSR is 170 kV. The inter-arm lightning impulse withstand voltage of HCSR is 200 kV. The terminal-to-ground lightning impulse withstand voltage of the HCSR-FCL is 1550 kV.
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Jirun, Peng, Guoxin Zhang, Hyun Kee Kim, Seon-Ah Ha, Jin Zhongtian, Qiao Shishi, Cui Zhuqingqing, et al. "Clinical Utility of Alpha Fetoprotein and HCCR-1, Alone or in Combination, in Patients with Chronic Hepatitis, Liver Cirrhosis and Hepatocellular Carcinoma." Disease Markers 30, no. 6 (2011): 307–15. http://dx.doi.org/10.1155/2011/698975.

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Serum alpha fetoprotein (AFP) is the most widely used tumor marker in detecting patients with hepatocellular carcinoma (HCC). However, it has been indicated that HCCR-1 (human cervical cancer oncogene 1) might be supplementary to AFP in the detection. We conducted a prospective study in 120 normal and 524 liver disease patients to evaluate the significance of simultaneous measurement of 2 tumor markers (AFP and HCCR-1) in the diagnosis of HCC through the cohort study in Korea and China. We also performed immunohistochemical studies using 25 normal subjects (N), 32 liver cirrhosis (LC) and 116 HCC tissues. The sensitivities of AFP (20 ng/mL) and HCCR-1 (10 ng/mL) in HCC were 55.8% (164/294) and 44.2% (130/294), respectively. When AFP was combined with HCCR-1, sensitivities increased to 4.2% (N), 12.7% (chronic hepatitis; CH), 50.0% (LC), and 77.2% (HCC), respectively. Although there was no significant difference in the diagnostic rate for HCC between AFP and HCCR-1, many cases for AFP-negative HCC were positive for HCCR-1 and vice versa. Moreover, the combined use of AFP and HCCR-1 improved the diagnostic rate to 70.8% in small HCC (< 2 cm) and 81.6% in large HCC (≥ 2 cm), respectively. AFP and HCCR-1 are independent markers. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.
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Bimonte, Sabrina, Maddalena Leongito, Antonio Barbieri, Vitale del Vecchio, Michela Falco, Aldo Giudice, Raffaele Palaia, et al. "The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells." Stem Cells International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1065230.

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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear. MicroRNAs (miRNAs) are able to regulate a lot of biological processes such as self-renewal and pluripotency of HCSCs, representing a new promising strategy for treatment of HCC chemotherapy-resistant tumors. In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment.
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Wang, Linbin, Rui Zhu, Yixin Pan, Peng Huang, Yuyan Tan, Boyan Fang, Jun Liu, and Dianyou Li. "Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson’s Disease and Parkinson Variant of Multiple System Atrophy: A Case Series." Brain Sciences 12, no. 9 (September 10, 2022): 1222. http://dx.doi.org/10.3390/brainsci12091222.

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High cervical spinal cord stimulation (HCSCS) was found to have therapeutic effects on Parkinsonian gait disturbance. However, the results were inconsistent and confounded with symptoms of pain. This study aimed to reveal the gait and dysarthric effects of HCSCS in PD (Parkinson’s disease) and MSA-P (Parkinson variant of multiple system atrophy) patients without pain. Three PD and five MSA-P patients without painful comorbidities were assessed for gait performance and speech before SCS surgery and at 3- and 6-month follow-up. Stride length and the time spent in the Timed Up-and-Go task showed little change after HCSCS surgery. Overall voice quality (measured by dysphonia severity index) and perceptual speech intelligence improved significantly at 3 months, but improvements slightly diminished at 6 months postoperatively. Change in quality of life (measured by 8-item Parkinson’s disease questionnaire) was also notable at 3 months but narrowed over time following HCSCS. In conclusion, HCSCS showed therapeutic effects in improving the dysarthria but not gait disturbance in pain-free PD and MSA-P patients.
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Zhang, Guoxin, Seon-Ah Ha, Hyun K. Kim, Jinah Yoo, Sanghee Kim, Youn S. Lee, Soo Y. Hur, et al. "Combined Analysis of AFP and HCCR-1 as an Useful Serological Marker for Small Hepatocellular Carcinoma: A Prospective Cohort Study." Disease Markers 32, no. 4 (2012): 265–71. http://dx.doi.org/10.1155/2012/964036.

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Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world. The only serological marker widely used for the diagnosis of HCC is alpha-fetoprotein (AFP). Despite that AFP is widely used for the diagnosis of HCC, it has a limit as a serological marker due to its low sensitivity and specificity. The human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported as a new biomarker for HCC. To further evaluate the HCCR-1 as a biomarker for HCC, we conducted the prospective cohort study. We evaluated the significance of simultaneous measurement of 2 tumor markers in the diagnosis of HCC in China, Japan and Korea. Two markers for HCC, AFP and HCCR-1, were measured in the sera obtained from 1,338 patients at the time of initial diagnosis of HCC. Of the 1338 HCC patients, 616 (46%) and 686 (51.3%) were sero-positive for AFP and HCCR-1, respectively. The positive rate for HCC was increased up to 74.1% in combined use of AFP and HCCR-1. Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa. More importantly, the diagnostic rate for small HCC (< 2 cm) was significantly improved in the combined analysis of AFP and HCCR-1 to 56.9% although it was only 40.1% and 23.4% in the single analysis of HCCR-1 and AFP, respectively. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.
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Dissertations / Theses on the topic "HCSCR"

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Boscarato, Ilan. "Integration of catalytic technology into marine engine pollution abatement system." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4501.

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2009/2010
La ricerca condotta nel presente lavoro di tesi è stata condotta nell’ambito del progetto ECOMOS. Il progetto consiste in ricerca di base e ricerca applicata e lo scopo del lavoro era sviluppate tecnologie innovative per l’abbattimento degli inquinanti gassosi prodotti da motori marini. In tal senso il lavoro è stato condotto su due filoni principali: - Uno riguardante la ricerca di base, in cui sono stati verificati gli effetti del supporto su catalizzatori a base di argento operanti in condizioni di miscela magra utilizzando un idroreattore catalitico. - Uno riguardante la ricerca applicata, che ha richiesto l’analisi e razionalizzazione dello stato dell’arte circa l’abbattimento delle emissioni gassose inquinanti nel settore marino allo scopo di proporre un modello di sistema integrato per l’abbattimento; la verifica della fattibilità della proposta utilizzando catalizzatori modello a base di platino; lo studio del disegno e la costruzione di un impianto micro pilota su scala di laboratorio per l’abbattimento delle emissioni di un motore marino facente uso di catalizzatori a base di Pt/Al2O3 ed infine la realizzazione di un impianto pilota con la collaborazione di Cetena. I principali risultati ottenuti possono essere riassunti in: - Ricerca di base: o Il supporto risulta avere un forte effetto sull’attività catalitica o L’attività catalitica può essere modificata scegliendo l’opportuno supporto o La resistenza all’avvelenamento provocato dalla presenza di zolfo nei gas può essere aumentata tramite l’introduzione di zirconia nel supporti, ma ulteriori test sono necessari per razionalizzare completamente quanto osservato - Ricerca applicata: o Il catalizzatore a base di platino supportato su allumina, Pt/Al2O3, ha dimostrato di essere stabile ed attivo anche in presenza di elevate concentrazioni di SO2 nella fase gassosa suggerendo la possibilità di utilizzo nel settore marino. o È stato identificato un inaspettato fenomeno di condensazione, per la cui completa caratterizzazione sono richiesti ulteriori test. o Acqua ed anidride carbonica hanno effetti limitati sull’ossidazione dell’ossido di azoto mentre sopprimono la reazione di condensazione. o La presenza di idrocarburi sopprime l’ossidazione di NO o I test sull’impianto pilota di laboratorio hanno dimostrato che il catalizzatore scelto è attivo nell’ossidazione di NO, ma si conferma la necessità di ossidare prima tutti gli HC. o È stata confermata la necessità di ossidare No ad NO2 qualora si vogliano abbattere le emissioni di ossidi di azoto tramite assorbimento in acqua di mare mentre si è confermata l’efficacia per l’abbattimento di SO2. o L’impianto di laboratorio ha consentito il dimensionamento del catalizzatore per l’impianto pilota. o I problemi riscontrati nell’impianto di laboratorio hanno suggerito modifiche che sono state applicate all’impianto pilota.
The research conducted in the present thesis was carried out within the framework of the ECOMOS project. The project consists of basic and applied research and overall scope of the work was to develop novel marine pollution abatement technologies. Accordingly, the work was carried out along two main directions: - fundamental research, in which the effect of the support on lean deNOx activity of Ag-based catalyst were investigated using a catalytic microreactor; - and applied research, which involved a recognition and rationalization of the state of the art in marine pollution abatement to purpose a model of integrated system; the verification of the feasibility of the purpose, using a model Pt catalyst; the study of the design, of the layout and the construction and testing of a laboratory-scale plant for the abatement of emissions from marine engines using Pt / Al2O3 catalysts and the dimensioning of a pilot plant in collaboration with Cetena. The main results found on the two directions are summarized in the following lists: - Basic studies: HC SCR on Ag based catalyst:  The support effect is clearly evidenced as a main contributor to catalytic activity;  The activity can be tuned by using appropriate supports;  The resistance to sulphur poisoning can be improved by the introduction of zirconia in the support, but further test are needed to fully address this observation; - Fundamental studies:  The Pt/Al2O3 catalyst tested in the microreactor demonstrated activity and stablity even in the presence of high SO2 concentration suggesting the possibility of its use in the marine sector;  An unexpected phenomenon was found, the condensation process in which NOx are dissolved in SO3 mists, which need further studies to be completely elucidated;  H2O and CO2 have only small negative influence on the NO oxidation but suppress the condensation;  HC suppress NO oxidation, the necessity of oxidising the HC before NO oxidation becomes effective, has been demonstrated;  Pilot plant tests revealed that the Ecocat catalyst is active for NO oxidation but the need to oxidise all the carbonaceous species was again confirmed;  The monolith has an activity comparable to that found in the microreactor studies using model mixtures. In this way activities of powdered catalysts could be related to honeycomb analogues;  The need to oxidize NO to NO2 to favour the absorption into the scrubber was confirmed;  The scrubber effectively abates SOx;  The problems of crusting and the excessive pressure drop found in the micro scrubber provided indications on how to modify the pilot plant;  The real plant design and construction has been completed, in cooperation with the industrial partners;  The catalytic section was designed and completed;  The pilot plant is now ready for the tests.
XXIII Ciclo
1983
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Olausson, Andreas, and Stefanus Louca. "Reviewing Code Review : Defining and developing High-level ConceptualCode Review at a financial technology company." Thesis, KTH, Lärande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273982.

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Code review is a recurring activity at software companies where the source code, orparts of it, undergoes an inspection where the aim is to detect possible errors beforethe code is released for production. A variation of code review that is common today iscalled modern code review and is more lightweight practise than formal code review. Inmodern code review, the developers participate and continuously revise their colleagues’code.At a financial technology company in Stockholm, modern code review is applied. Thecompany has expressed a need to implement a tool that can facilitate the code reviewprocess. One suggestion from the company was to implement high-level conceptual codereview (HCCR), an idea of a tool where code changes are sorted automatically intodifferent commits with a specific message.In order to implement the tool, HCCR needs to be defined and concretised since it haspreviously existed solely as an idea. As a first step of the project, developers’ view ofwhat information is desirable in a commit needed to be examined. The project addressedthe following research questions: What information is desirable and needed by the developers of a medium-sizedcompany, to help them do code reviews in a pull-based environment?– What should the information consist of?– How should the information be presented?To answer these questions, interviews were conducted with software developers at thecompany, together with observations where the developers had to try out a first iterationof HCCR. The first iteration was developed using the company’s guidelines on howdevelopers contribute to code changes together with our company supervisor’s viewson how the tool can work. The interviews were recorded and transcribed, whereafteriia thematic analysis was applied. From the analysis, 13 concepts emerged, which weredivided into five categories. The developers wanted the commits to be atomic, compilableand testable in order to facilitate debugging. The developers also expressed a need toget clear information about both pull-requests (PRs) and commit messages. In theinterviews, a theme emerged that the messages should consist of: what has changed andwhy it has changed. Differences were also observed in the code review process as differentdevelopers use different strategies when reviewing code.Based on the information that emerged from the interviews and observations along withprevious research, a second iteration of HCCR was prepared. The report concludes bydiscussing possible implementations of the tool.
Kodgranskning är en vanligt förekommande aktivitet hos mjukvaruföretag där källkoden,eller delar av den, genomgår en granskning för att upptäcka möjliga fel innan kodensläpps till produktion. En variation av kodgranskning som är vanlig idag kallas modernkodgranskning och är en mindre formell kodgranskning där utvecklarna själva är medoch kontinuerligt reviderar sina kollegors kod.Ett finansiellt teknikbolag i Stockholm tillämpar modern kodgranskning. Företagethar uttryckt ett behov av att implementera ett verktyg som kan underlättakodgranskningsprocessen. Ett förslag från företaget var att implementera HCCR, enidé om ett verktyg där kodändringar automatiskt sorteras till olika, så kallade, commits1med ett specifikt meddelande.För att implementera verktyget behöver HCCR definieras och konkretiseras. Som ettförsta steg i projektet behövde vi undersöka utvecklarnas önskvärda information av huren commit bör utformas. Projektet behandlar följande forskningsfrågor: Vilken information är önskvärd och behövs av utvecklarna på ett medelstort företag,för att hjälpa dem att göra kodgranskningar i en pull-based miljö?– Vad ska informationen bestå av?– Hur skall informationen presenteras?För att svara på frågorna gjordes intervjuer med mjukvaruutvecklarna på företagettillsammans med observationer där utvecklarna fick prova på en första iteration avHCCR. Den första iterationen togs fram genom att använda företagets riktlinjer gällandehur utvecklare bidrar med kodändringar tillsammans med åsikter från handledaren påföretaget om hur verktyget kan fungera. Intervjuerna spelades in och transkriberades1När det kommer till ord och uttryck inom Git, (exempelvis commits, pull-request, push, pull) finnsdet ingen standardiserad översättning till svenska. Därför kommer dessa ord skrivas på engelska isammanfattningen.ivvarpå en tematisk analys genomfördes. Från analysen framträdde 13 koncept kringkodgranskning vilka delades in i fem kategorier. Utvecklarna önskade att varje commitskulle vara atomisk, kompilerbar samt testbar för att underlätta felsökning av buggar.Utvecklarna uttryckte också ett behov av att få tydlig information om både PR ochcommit-meddelanden. I intervjuerna framkom det att meddelandena borde bestå av:vad som har ändrats och varför det har ändrats. Det observerades även skillnader ikodgranskningsprocessen då olika utvecklare använder olika strategier när de granskarkod.Baserat på den information som framträdde från intervjuerna och observationernatillsammans med tidigare forskning utarbetades en andra iteration av HCCR. Rapportenavslutas med att diskutera möjliga implementationer av verktyget.
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Hocine, Hocine Rachid. "La réponse immunitaire allogénique contre les cellules souches cardiaques humaines." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC320/document.

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L’augmentation de la moyenne de vie a modifié le spectre des maladies cardiaques vers l'insuffisance cardiaque, un désordre progressif incurable, marqué par une perte massive de cardiomyocytes. En raison de la rareté des donneurs, la transplantation cardiaque, devient de plus en plus difficile. En 2003, la découverte des cellules souches cardiaques humaines (hCSC) pouvant supporter la réparation du myocarde après un infarctus a soulevé l’espoir d’approches thérapeutiques plus prometteuses. La transplantation des cellules autologues (issues du patient) a montré une efficacité limitée en raison de la mauvaise qualité des cellules après infarctus. De ce fait, l’utilisation des CPC allogéniques provenant de donneurs sains semble aujourd’hui le choix le plus réaliste et représente un potentiel produit thérapeutique abordable et disponible pour tous. Cependant les cellules allogéniques soulèvent des problèmes immunologiques importants qu’il faut résoudre avant leur utilisation clinique. Concernant la réponse immune innée, nos résultats indiquent que les hCPC allogéniques ont une susceptibilité modeste à la lyse NK et pourraient même être protégées contre cette lyse en contexte inflammatoire. Contrairement à la réponse immunitaire innée favorable contre les hCPC allogéniques, la présence des alloanticorps anti-HLA peut être néfaste. Nos résultats ont montré que les DSA-HLA I spécifiques de l’haplotype des hCPC peuvent induire leur lyse par CDC et ADCC et cette lyse est fortement augmentée par les conditions inflammatoires. L’ensemble de ces résultats indique que les hCPC allogéniques sont des cellules à faible risque immunologique en ce qui concerne la réponse immune innée, par contre une élimination rapide par CDC ou tardive par ADCC des hCPC pourrait se produire chez les patients ayant des DSA-HLA I spécifiques de l’allèle(s) exprimé(s) par les hCPC incitant ainsi le dépistage des DSA-HLA avant l’infusion thérapeutique des hCPC
The increase in average life changed the spectrum of heart disease to heart failure, a progressive incurable disorder, characterized by a massive loss of cardiomyocytes. Due to the scarcity of donors, cardiac transplantation, only effective treatment known to date is becoming increasingly difficult. In 2003, the discovery of human cardiac stem cells (HCS/PC) can support the repair of the myocardium after myocardial raised hopes of promising therapeutic approaches. Transplantation of autologous (from the patient) showed limited efficiency because of the poor quality of the cells after infarction. Therefore, the use of stem / progenitor heart (CPC) from allogeneic healthy donors seems today the most realistic choiceand represents a potential therapeutic product available to all. However allogeneic cells raise significant immunological problems that must be resolved before clinical use. Regarding the innate immune response, our results indicate that allogeneic HCPC have a modest susceptibility to NK lysis and could even be protected against this lysis in the inflammatory context. In addition, allogeneic HCPC seem able to inhibit the activity of NK cells. Unlike the favorable innate immune response against the allogeneic HCPC, the presence of anti-HLA alloantibodies can be harmful. Our results showed that the DSA-specific HLA class I haplotype of the HCPC can induce their lysis by CDC and ADCC and this lysis is greatly increased by inflammatory conditions. However, the DSA-specific HLA II do not induce HCPC lysis. All these results indicate that allogeneic HCPC are cells with low immunological risk regarding the innate immune response. On the contrary, rapid elimination by CDC or ADCC of HCPC may occurs in patients with DSA- HLA class I specific allele (s) expressed by the HCPC thus prompting the screening of HLA-DSA prior to therapeutic infusion of HCPC
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Reis, Ivo Miguel Ferreira da Paixão. "Unveiling human Cardiac Stem Cells role in myocardial ischemia-reperfusion injury." Master's thesis, 2018. http://hdl.handle.net/10362/51572.

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Books on the topic "HCSCR"

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Reprints, Retro Comic. E.C. Comic's Picture Stories from American History Hcsc: Collecting All Four E.C. Issues Retro Comic Reprints #158. RETRO COMIC REPRINTS, 2022.

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Reprints, Retro Comic. E.C. Comic's Picture Stories from World History and Science Hcsc: Collecting Both Complete E.C. Series Retro Comic Reprints #166. RETRO COMIC REPRINTS, 2022.

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Reprints, Retro Comic. E.C. Comic's Picture Stories from History and Science Giant-Size Hardcover Hcsc: Collecting Three Complete E.C. Series Retro Comic Reprints #207. RETRO COMIC REPRINTS, 2022.

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Book chapters on the topic "HCSCR"

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Weiss, Jeffrey N. "The Transendocardial Autologous Cells (hMSC) or (hMSC) and (hCSC) in Ischemic Heart Failure Trial." In Stem Cell Surgery Trials in Heart Failure and Diabetes, 13–19. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-78010-4_3.

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Kumar, Amit, and Mohan K. Pradhan. "EDM Process Optimization of Machining Parameters for Through Hole Making on HCHCR AISI-D7 Steel Using RSM." In Lecture Notes in Mechanical Engineering, 179–95. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8341-1_15.

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Sathish Kumar, M., and B. Satyanarayana. "Optimization of Process Parameters in W-EDM with HCHCR by Using Taguchi Optimization Technique and Grey Relational Analysis." In Lecture Notes in Mechanical Engineering, 55–66. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5347-7_5.

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Kumar, Sandeep, and Abhishek Singh. "Multi-objective Optimization of Powder Mixed Green-EDM Parameters on Machining of HcHcr Steel Using an Integrated MCDM Approach." In Lecture Notes in Mechanical Engineering, 199–214. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-7150-1_17.

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Kumar, Sandeep, Jagadish, and Amitava Ray. "Multi-objective Optimization of CNC Drilling Parameters on Machining of HcHcr Steel Using Taguchi’s Technique and Grey Relational Analysis." In Advances in Thermal Engineering, Manufacturing, and Production Management, 353–67. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2347-9_31.

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Russell, Cynthia. "A Nurse’s Perspective." In Health Care & Spirituality: Listening, Assessing, Caring. Baywood Publishing Company, Inc., 2000. http://dx.doi.org/10.2190/hcsc1.

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Stewart, Richard. "A Chaplain’s Perspective: The Early Years Reverend." In Health Care & Spirituality: Listening, Assessing, Caring. Baywood Publishing Company, Inc., 2000. http://dx.doi.org/10.2190/hcsc2.

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Gilbert, Richard B. "A Chaplain’s Perspective: The Challenge for Today Reverend." In Health Care & Spirituality: Listening, Assessing, Caring. Baywood Publishing Company, Inc., 2000. http://dx.doi.org/10.2190/hcsc3.

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Adams, David W. "A Beginning Examination of the Spirituality of Health Care Professionals." In Health Care & Spirituality: Listening, Assessing, Caring. Baywood Publishing Company, Inc., 2000. http://dx.doi.org/10.2190/hcsc4.

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Morgan, John D. Morgan. "Dying and Grieving are Journeys of the Spirit John D. Morgan." In Health Care & Spirituality: Listening, Assessing, Caring. Baywood Publishing Company, Inc., 2000. http://dx.doi.org/10.2190/hcsc5.

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Conference papers on the topic "HCSCR"

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Sharmin, Moushumi, and Jalal Mahmud. "Message from HCSC Organizing Committee." In 2017 IEEE 41st Annual Computer Software and Applications Conference (COMPSAC). IEEE, 2017. http://dx.doi.org/10.1109/compsac.2017.297.

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Guo, Yuanfan, Minghao Xu, Jiawen Li, Bingbing Ni, Xuanyu Zhu, Zhenbang Sun, and Yi Xu. "HCSC: Hierarchical Contrastive Selective Coding." In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2022. http://dx.doi.org/10.1109/cvpr52688.2022.00948.

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Liu, Yuhong, Symeon Papadopoulos, Rene Kaiser, and Moushumi Sharmin. "Message from the HCSC Organizing Committee." In 2016 IEEE 40th Annual Computer Software and Applications Conference (COMPSAC). IEEE, 2016. http://dx.doi.org/10.1109/compsac.2016.252.

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Sharmin, Moushumi, Katsunori Oyama, and Claudio Giovanni Demartini. "Message from the HCSC 2018 Workshop Organizers." In 2018 IEEE 42nd Annual Computer Software and Applications Conference (COMPSAC). IEEE, 2018. http://dx.doi.org/10.1109/compsac.2018.00050.

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Nagy, Peter A., and Douglas R. Moore. "Hard-clad-silica(HCSR)-fused biconical taper couplers." In Fiber Optic Components and reliability, edited by Paul M. Kopera and Dilip K. Paul. SPIE, 1992. http://dx.doi.org/10.1117/12.135399.

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Sun, Limin. "HCCR by contour-based elastic mesh fuzzy feature." In Electronic Imaging 2006, edited by Kazem Taghva and Xiaofan Lin. SPIE, 2006. http://dx.doi.org/10.1117/12.648608.

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Zhu, Chen, and Jie Huang. "Fiber-Optic Extrinsic Fabry-Perot Interferometer Inspired Microwave Device: A Novel Ultra-Sensitive Sensing Platform." In Optical Fiber Sensors. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/ofs.2022.th4.6.

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Inspired by the fiber-optic extrinsic Fabry-Perot interferometer, we report a novel and universal ultra-sensitive microwave Fabry-Perot sensing platform based on an open-ended hollow coaxial cable resonator (OE-HCCR) for sub-nanometer displacement sensing.
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Dong Won Lee, Hyung Gon Jin, Eo Hwak Lee, Suk-Kwon Kim, Jae Sung Yoon, Kyu In Shin, and Seungyon Cho. "Thermal-hydraulic analysis for conceptual design of Korean HCCR TBM-set." In 2015 IEEE 26th Symposium on Fusion Engineering (SOFE). IEEE, 2015. http://dx.doi.org/10.1109/sofe.2015.7482299.

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Sun, Limin, and Zhaoxin Gai. "Research on classifying performance of SVMs with basic kernel in HCCR." In Electronic Imaging 2006, edited by Edward R. Dougherty, Jaakko T. Astola, Karen O. Egiazarian, Nasser M. Nasrabadi, and Syed A. Rizvi. SPIE, 2006. http://dx.doi.org/10.1117/12.642553.

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Lee, Dong Won, Hyung Gon Jin, Kyu In Shin, Eo Hwak Lee, Suk-Kwon Kim, Jae Sung Yoon, Mu-Young Ahn, and Seungyon Cho. "Functional components design and analysis of a Korean HCCR TBM in ITER." In 2013 IEEE 25th Symposium on Fusion Engineering (SOFE). IEEE, 2013. http://dx.doi.org/10.1109/sofe.2013.6635374.

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