Dissertations / Theses: 'HCh models'

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Ilyina, Tatjana P. "The fate of persistent organic pollutants in the North Sea multiple year model simulations of {[gamma]-HCH [gamma-HCH], {[alpha]-HCH [alpha-HCH] and PCB 153." Berlin Heidelberg New York Springer, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2874201&prov=M&dok_var=1&dok_ext=htm.

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Ilyina, Tatjana P. "The fate of persistent organic pollutants in the North Sea : multiple year model simulations of [gamma]-HCH, [alpha]-HCH and PCB 153 /." Berlin [u.a.] : Springer, 2007. http://www.loc.gov/catdir/toc/fy0710/2006939205.html.

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Sandberg, Daniel. "Experiments, Computations and Models for Probabilistic HCF Design." Doctoral thesis, KTH, Hållfasthetslära (Avd.), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-182436.

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High Cycle Fatigue (HCF) failure is a common failure type for many mechanical components. Traditional HCF design is based on the deterministic safety factor approach, typically used in conjunction with the point stress method. A current development is to explicitly model the uncertainty of the design set-up, and compute the probability of failure, pf. If pf can be computed in an appropriate way, the contributions to fatigue can be identified and managed. Probabilistic design gives improved control over safety, which helps to avoid overly conservative design. One of the applications dealt with in this work is gas turbine compressor blades. For this type of component requirements on safety coincide with requirements on high efficiency, low weight, etc. In such case, methods for accurate fatigue assessment become extra important. In order to perform an appropriate fatigue design, certain requirements must be fulfilled. For example, the fatigue model that is used must be accurate and the relevant material parameters must be accurately determined. Other requirements are that the mesh used in the FE-computations for the stress field is fine enough, a HCF post-processor that enables application of fatigue models to real components must be available and a method for computation of pf including all uncertainties should also be available. In Paper A, it is shown that for a gas turbine compressor blade, it is the number of elements through the blade’s thickness that is the most important mesh property for convergence in . In Paper B, it is investigated which test strategy that should be used in order to perform accurate estimations of material parameters in multiaxial HCF criteria by use of as few laboratory tests as possible when different types of scatter are present, and when the cost to perform the fatigue tests is taken into consideration. It is shown that performing tests on few stress ratios located far away from each other is the best strategy, and that for tests performed in a high quality laboratory, scatter in specimen misalignment has an insignificant influence on the parameter estimation. In Papers C and D, the prediction accuracy for the probabilistic volume based Weakest Link (WL) model and the Volume method for the Probability of Fatigue (VPF) is investigated. A novel specimen design is suggested for investigation of the volume effect. Based on the results, the newly developed VPF is favoured for design purpose. In Paper D, the HCF post-processor AROMA-PF is also presented, and used for computation of pf for a real gas turbine compressor blade geometry. The behavior of the predicted fatigue probability curves is very different between WL and the VPF for low pf-values. In Paper E, a new method for fatigue probability assessment is presented. The classification of aleatory uncertainty type 1 and type 2 is also introduced. The suggested method is applied to a bladed disk in a gas turbine for computation of pf. The results show that the epistemic uncertainty in the modeling of the aero-forcing gives the major contribution to uncertainty in pf.

QC 20160222

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Blackburn, Ian Russell. "A conceptual multi-model HCI model for the blind." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/575.

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The ability for blind people to read and write Braille aids literacy development. A good level of literacy enables a person to function well in society in terms of employment, education and daily living. The learning of Braille has traditionally been done with hard copy Braille produced by manual and more recently electronic Braille writers and printers. Curtin University is developing an electronic Braille writer and the research on an interface for Braille keyboard devices, presented in this thesis, forms part of the Curtin University Brailler project.The Design Science approach was the research method chosen for this research because of the flexibility of the approach and because it focuses upon the building of artefacts and theory development. The small sample size meant that both individual interviews and a focus group were employed to gather relevant data from respondents. The literature review covers a variety of areas related to computer interfaces and Braille keyboard devices. A key finding is that the interaction paradigm for Braille keyboard devices needs to differ to interfaces for sighted individuals because of the audio, tactile and serial nature of the information gathering strategies employed by blind people as compared with the visual and spatial information gathering strategies employed by sighted individuals. In terms of usability attributes designed to evaluate the interface consistency was found to be a key factor because of its importance to learning and memory retention.However, two main functions carried out on a computer system are navigating and editing. Thus the model of interface for Braille keyboard devices presented in this thesis focuses upon navigation support and editing support.Feedback was sort from by interviews with individuals and a focus group. Individual interviews were conducted face to face and via the telephone and the focus group was conducted via Skype conference call to enable participants from all over the world to provide feedback on the model.The model was evaluated using usability attributes. Usability was important to the respondents, in particular consistency, learnability, simplicity and ease of use were important. The concept of rich navigation and infinitely definable key maps were understood by respondents and supported. Braille output is essential including the ability to show formatting information in Braille.The limitations of the research included the few respondents to the interviews and the choice to focus upon a theoretical model rather than implementing the model on an actual device. Future research opportunities include implementing the interface concepts from the model on to touch screen devices to aid further development of the interface and implementing the interface on a physical device such as the Curtin University Brailler.

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Sandberg, Daniel. "Use of Experiments, Computations and Models for HCF Design." Licentiate thesis, KTH, Hållfasthetslära (Inst.), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-160354.

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Oshlyansky, Lidia. "Cultural models in HCI : Hofstede, affordance and technology acceptance." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42813.

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There are many models of culture available to Human-Computer Interaction (HCI) researchers and industry sector practitioners that could potentially help in tackling the challenge of designing across cultures. Models by Hall and Hofstede (investigated in this thesis) among others, are used by the HCI community to shape research, frame research findings and inform design. However, very limited information is available that proves the applicability of these models to the field. There is currently no large scale, multi-country study that addresses the suitability and applicability of cultural models to the topical areas covered by HCI. The consequence of this lack of validated applicability is that the community, due to a lack of tools or knowledge, have to rely on guesswork or rules of thumb when tackling cross-cultural research and design. The research described here sets out to investigate when cultural models can be applied and to which HCI topics. This thesis explores the relationship and applicability of Hofstede's cultural model to two HCI topics which span Ito and Nakakoji's (1996) model of cultural impact on interaction. These two topics are cross-cultural affordance and cross-cultural technology acceptance. The thesis contingently also looks at the viability of doing cross-cultural research by using standardised tools and measures. The first study described here was a research project exploring the differences in affordances between two cultures and how or if Hofstede's cultural model could be applied to explain the findings of this study. The results from the affordance study showed that cultural differences do exist at the affordance level of interaction. However, Hofstede's cultural model could not help explain HCI at the lower end of Ito and Nakakoji's cultural influence model, at the level of affordance. The affordance study also provided useful insight into the questionnaire method used for gathering data in the second, larger scale project on technology acceptance. The second study which focused on cross-cultural technology acceptance, at the high end of Ito and Nakakoji's model, was a large scale, multinational, exploratory study. It investigated how Hofstede's cultural model could assist in understanding cross-cultural differences in technology acceptance as expressed when using websites. The research sought to understand how and if Hofstede's cultural model as measured by the Value Survey Module (VSM) would correlate with website acceptance as measured by the Unified Theory Acceptance and Use of Technology (UTAUT). Both models were measured using questionnaires in 11 countries and 6 different languages. Results of this second study showed that Hofstede's model was not helpful at the higher end of Ito and Nakakoji's cultural influence model. Indeed the results cast doubt as to the validity of Hofstede's model as measured by the VSM while validating the use of the UTAUT cross-culturally.

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Buschmann, Udo. "Modellierung und Simulation von Hoch-Temperatur-Korrosionsprozessen." Düsseldorf VDI-Verl, 2008. http://d-nb.info/993723861/04.

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Rocha, Marcio. "New routes to HCI : a transdisciplinary approach." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/3767.

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This thesis bring together different disciplines – philosophy of mind, artificial intelligence, cognitive science, cybernetics and the performing arts – in a transdisciplinary investigation that raises new questions about the human mind and our relationship with computers and machines in a way that contributes to and helps elucidate the human computer interaction (HCI) debate. It chooses transdisciplinarity as the methodology best able to mobilize new ideas and generate a different approach to HCI, one that will develop fresh insights and produce critical ways of thinking about the problems of contemporary life in relation to our interaction with technologies (in the broadest sense of the term). The thesis reconciles the artificial with human nature by using transdisciplinary methods to reduce the friction between human beings and computers. It does this by revisiting early mechanical machines and automatons (from mythology and science), as well as exploring the subject in relation to elements of the performing arts. In the process, the thesis confronts the concepts of ‘artificial’ and ‘natural’ intelligence, and explores various models of mind and intelligence, as well as examining the physicality or materiality of artefacts in terms of their congruence with the paradigm of the ‘embodied mind’. The preliminary studies and literature review carried out for the research revealed that the model of the mind currently proposed by HCI as the basis for theories of how humans interact with computers is unsatisfactory, limited and very problematic, not least because it is a disembodied and representational conception of the human mind. In order to relieve HCI of this problematic issue, the thesis introduces the concept of the ‘embodied mind’, which brings a deeper understanding of how the mind works; its recognition that the human mind, body and the world are interrelated entities gives us a new insight into how we can improve our interactions with machines and computers. To achieve this, the research explores the conceptualization of human characteristics such as intelligence and cognition, and confirms 7 that these concepts are subject to change, manifested in different forms, distributed, situated and contextualized. Intelligence is not interpreted as a literal entity, as it is in cognitive psychology, or as a quality that belongs to or empowers human beings alone, but inspired by the philosophy of artificial intelligence (AI), the thesis argues that it is a manifestation that ‘emerges’ when favourable conditions facilitate interactions between agents and artefacts. Through a focused analysis and interpretation of early automatons, robots, and artificial and mechanical machines, the study explores the concept that technology is both a practice and an imaginative idea, and not just a concrete manifestation of a solution to human problems. It perceives automatons, especially ‘fraudulent’ automatons, as true archaeological discoveries, evidence of the fact that our human ambitions and ideas are not limited by the technological expressions of different eras; they represent a special repository of the desire to capitalize on and make such ideas manifest even when the technology for their materialization is not yet available. The thesis also brings ventriloquism and puppetry into the discussion, as both objects and performative practices, in order to highlight the human relationship with the material environment, as well as related aspects of human and non-human agency. This indicates that cybernetics could prove a useful framework for an understanding of elements of the relationship between the human and the artificial. The thesis therefore tackles the problems and limitations imposed by cognitive science, computer science and psychology, currently the main disciplines concerned with improving human relationships with computers and machines, but more specifically, it offers a more historically and philosophically informed contribution to the study of HCI.

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Ng, Wing Lon. "Ökonometrische Modellierung von Durationsprozessen ultra-hoch frequenter Orderbuchdaten /." Berlin : Logos-Verl, 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014770244&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Dijana, Karuović. "Model korisničkog interfejsa interaktivnog obrazovnog softvera." Phd thesis, Univerzitet u Novom Sadu, Tehnički fakultet Mihajlo Pupin u Zrenjaninu, 2009. http://dx.doi.org/10.2298/NS20091014KARUOVIC.

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Oblast istraživanja ove disertacije obuhvata interakciju čoveka i računara.Kreirani su: model korisničkog interfejsa, sa smernicama za kvalitetnijurealizaciju obrazovnih softvera namenjenih najmlađim korisnicima, modelobrazovnog softvera na zakonima FITSA, kurikulum nastavnog predmetaInterakcija čoveka i računara. Očekivano poboljšanje obrazovnih efekatanastave prikazano je kroz vrednovanje rezultata istraživanja ostvarenihtestiranjem preciznosti prilikom rešavanja testova znanja kod onih testova kojise prilagođavaju performansama korisnika.
The research area of this thesis includes the interaction of man andcomputer. Model of the user interface, with guidelines for betterimplementation of educational software for the youngest users, a model ofeducational software to the laws Fits, curriculum teaching subject interactionof man and computer were created. Expected improvement of the educationaleffects of teaching is shown through the evaluation of results achieved whentesting the accuracy of solving tests in those tests that adapt to userperformance.

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Holz, Christian. "3D from 2D touch." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6779/.

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While interaction with computers used to be dominated by mice and keyboards, new types of sensors now allow users to interact through touch, speech, or using their whole body in 3D space. These new interaction modalities are often referred to as "natural user interfaces" or "NUIs." While 2D NUIs have experienced major success on billions of mobile touch devices sold, 3D NUI systems have so far been unable to deliver a mobile form factor, mainly due to their use of cameras. The fact that cameras require a certain distance from the capture volume has prevented 3D NUI systems from reaching the flat form factor mobile users expect. In this dissertation, we address this issue by sensing 3D input using flat 2D sensors. The systems we present observe the input from 3D objects as 2D imprints upon physical contact. By sampling these imprints at very high resolutions, we obtain the objects' textures. In some cases, a texture uniquely identifies a biometric feature, such as the user's fingerprint. In other cases, an imprint stems from the user's clothing, such as when walking on multitouch floors. By analyzing from which part of the 3D object the 2D imprint results, we reconstruct the object's pose in 3D space. While our main contribution is a general approach to sensing 3D input on 2D sensors upon physical contact, we also demonstrate three applications of our approach. (1) We present high-accuracy touch devices that allow users to reliably touch targets that are a third of the size of those on current touch devices. We show that different users and 3D finger poses systematically affect touch sensing, which current devices perceive as random input noise. We introduce a model for touch that compensates for this systematic effect by deriving the 3D finger pose and the user's identity from each touch imprint. We then investigate this systematic effect in detail and explore how users conceptually touch targets. Our findings indicate that users aim by aligning visual features of their fingers with the target. We present a visual model for touch input that eliminates virtually all systematic effects on touch accuracy. (2) From each touch, we identify users biometrically by analyzing their fingerprints. Our prototype Fiberio integrates fingerprint scanning and a display into the same flat surface, solving a long-standing problem in human-computer interaction: secure authentication on touchscreens. Sensing 3D input and authenticating users upon touch allows Fiberio to implement a variety of applications that traditionally require the bulky setups of current 3D NUI systems. (3) To demonstrate the versatility of 3D reconstruction on larger touch surfaces, we present a high-resolution pressure-sensitive floor that resolves the texture of objects upon touch. Using the same principles as before, our system GravitySpace analyzes all imprints and identifies users based on their shoe soles, detects furniture, and enables accurate touch input using feet. By classifying all imprints, GravitySpace detects the users' body parts that are in contact with the floor and then reconstructs their 3D body poses using inverse kinematics. GravitySpace thus enables a range of applications for future 3D NUI systems based on a flat sensor, such as smart rooms in future homes. We conclude this dissertation by projecting into the future of mobile devices. Focusing on the mobility aspect of our work, we explore how NUI devices may one day augment users directly in the form of implanted devices.
Die Interaktion mit Computern war in den letzten vierzig Jahren stark von Tastatur und Maus geprägt. Neue Arten von Sensoren ermöglichen Computern nun, Eingaben durch Berührungs-, Sprach- oder 3D-Gestensensoren zu erkennen. Solch neuartige Formen der Interaktion werden häufig unter dem Begriff "natürliche Benutzungsschnittstellen" bzw. "NUIs" (englisch natural user interfaces) zusammengefasst. 2D-NUIs ist vor allem auf Mobilgeräten ein Durchbruch gelungen; über eine Milliarde solcher Geräte lassen sich durch Berührungseingaben bedienen. 3D-NUIs haben sich jedoch bisher nicht auf mobilen Plattformen durchsetzen können, da sie Nutzereingaben vorrangig mit Kameras aufzeichnen. Da Kameras Bilder jedoch erst ab einem gewissen Abstand auflösen können, eignen sie sich nicht als Sensor in einer mobilen Plattform. In dieser Arbeit lösen wir dieses Problem mit Hilfe von 2D-Sensoren, von deren Eingaben wir 3D-Informationen rekonstruieren. Unsere Prototypen zeichnen dabei die 2D-Abdrücke der Objekte, die den Sensor berühren, mit hoher Auflösung auf. Aus diesen Abdrücken leiten sie dann die Textur der Objekte ab. Anhand der Stelle der Objektoberfläche, die den Sensor berührt, rekonstruieren unsere Prototypen schließlich die 3D-Ausrichtung des jeweiligen Objektes. Neben unserem Hauptbeitrag der 3D-Rekonstruktion stellen wir drei Anwendungen unserer Methode vor. (1) Wir präsentieren Geräte, die Berührungseingaben dreimal genauer als existierende Geräte messen und damit Nutzern ermöglichen, dreimal kleinere Ziele zuverlässig mit dem Finger auszuwählen. Wir zeigen dabei, dass sowohl die Haltung des Fingers als auch der Benutzer selbst einen systematischen Einfluss auf die vom Sensor gemessene Position ausübt. Da existierende Geräte weder die Haltung des Fingers noch den Benutzer erkennen, nehmen sie solche Variationen als Eingabeungenauigkeit wahr. Wir stellen ein Modell für Berührungseingabe vor, das diese beiden Faktoren integriert, um damit die gemessenen Eingabepositionen zu präzisieren. Anschließend untersuchen wir, welches mentale Modell Nutzer beim Berühren kleiner Ziele mit dem Finger anwenden. Unsere Ergebnisse deuten auf ein visuelles Modell hin, demzufolge Benutzer Merkmale auf der Oberfläche ihres Fingers an einem Ziel ausrichten. Bei der Analyse von Berührungseingaben mit diesem Modell verschwinden nahezu alle zuvor von uns beobachteten systematischen Effekte. (2) Unsere Prototypen identifizieren Nutzer anhand der biometrischen Merkmale von Fingerabdrücken. Unser Prototyp Fiberio integriert dabei einen Fingerabdruckscanner und einen Bildschirm in die selbe Oberfläche und löst somit das seit Langem bestehende Problem der sicheren Authentifizierung auf Berührungsbildschirmen. Gemeinsam mit der 3D-Rekonstruktion von Eingaben ermöglicht diese Fähigkeit Fiberio, eine Reihe von Anwendungen zu implementieren, die bisher den sperrigen Aufbau aktueller 3D-NUI-Systeme voraussetzten. (3) Um die Flexibilität unserer Methode zu zeigen, implementieren wir sie auf einem großen, berührungsempfindlichen Fußboden, der Objekttexturen bei der Eingabe ebenfalls mit hoher Auflösung aufzeichnet. Ähnlich wie zuvor analysiert unser System GravitySpace diese Abdrücke, um Nutzer anhand ihrer Schuhsolen zu identifizieren, Möbelstücke auf dem Boden zu erkennen und Nutzern präzise Eingaben mittels ihrer Schuhe zu ermöglichen. Indem GravitySpace alle Abdrücke klassifiziert, erkennt das System die Körperteile der Benutzer, die sich in Kontakt mit dem Boden befinden. Aus der Anordnung dieser Kontakte schließt GravitySpace dann auf die Körperhaltungen aller Benutzer in 3D. GravitySpace hat daher das Potenzial, Anwendungen für zukünftige 3D-NUI-Systeme auf einer flachen Oberfläche zu implementieren, wie zum Beispiel in zukünftigen intelligenten Wohnungen. Wie schließen diese Arbeit mit einem Ausblick auf zukünftige interaktive Geräte. Dabei konzentrieren wir uns auf den Mobilitätsaspekt aktueller Entwicklungen und beleuchten, wie zukünftige mobile NUI-Geräte Nutzer in Form implantierter Geräte direkt unterstützen können.

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Högye, Sebastian, and Tommie Andersson. "Konkursprediktionsmodeller Inom Tillverknings- och detaljhandelsbranschen." Thesis, Södertörns högskola, Företagsekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-41318.

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Research question: Three models, Z``-score, O-score and Skogsvik HCA model, will be used in this study to examine Swedish companies who has gone bankrupt over the last decade within the manufacturing and retail branches. The study will examine how these models stand against each other when it comes to predict bankruptcy within these two branches one and two years in advance. Purpose: The purpose with this study is to examine these three models that are used for bankruptcy prediction and to get an understanding of why the accuracy differs between the models when it comes to predicting bankruptcy within the manufacturing and retail branches. Method: The study is based on a quantitative method with a deductive research approach to examine the accuracy of the three models when it comes to one and two years before bankruptcy. Conclusion: The study shows that Skogsvik’s model is the most accurate when it comes to predicting bankruptcy within the manufacturing and retail branches.
Problemställning: Tre modeller, Z``-scoremodellen, O-scoremodellen och skogsviks HCA modell, kommer att användas i vår studie för att undersöka svenska aktiebolag som gått i konkurs det senaste decenniet inom tillverkningsbranschen och detaljhandelsbranschen. Studien kommer undersöka hur dessa tre modeller står sig mot varandra när det kommer till att förutspå konkurser inom tillverknings- och detaljhandelsbranschen under en prediktionstid på både ett och två år i förväg. Syfte: Syftet med uppsatsen är att undersöka tre olika modeller som används för konkursprediktion och få en förståelse varför träffsäkerheten skiljer sig mellan de olika modellerna när det gäller att förutse konkurs inom tillverkningsbranschen och detaljhandelsbranschen. Metod: Studien bygger på en kvantitativ metod med en deduktiv ansats för att undersöka hur stor träffsäkerhet som redan befintliga modeller har vid förutsägelser av framtida konkurser på upp till två år. Slutsats: Studien visar att Skogsviks modell är den som är mest träffsäker när det gäller att förutse konkurser inom tillverknings- och detaljhandelsbranschen.

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Nacheva, Maria. "Mikromodell für den Wärmeübergang bei der Sprühkühlung hoch erhitzter Metalloberflächen." Magdeburg docupoint-Verl, 2009. http://d-nb.info/996364749/04.

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Scherling, Nicole. "Cell-mediated immune responses observed after the adoptive transfer of HCV-primed splenocytes in an HCV transgenic mouse model." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27726.

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HCV is a positive stranded RNA virus that infects up to 170 million people worldwide. Chronic infection is established in 80% of the cases and may lead to cirrhosis and hepatocellular carcinomas. A major debate regarding chronic HCV pathogenesis is whether liver damage is host or virus mediated. CD4+ and CD8+ immune responses are needed to control infection but these are often inefficient, resulting in chronic infection. The presence of these responses in chronic infection may contribute to liver pathogenesis. To study the relevance of immune-mediated liver damage, we created an immunization regimen which elicited humoral and cellular immune responses in B6C3F1 mice. HCV-primed donor splenocytes were stained with CFSE and transferred to a CE1E2 HCV Tg mouse model. Donor cells were recovered in various organs eight days following the transfer. HCV-primed CD4+ and CD8+ T cells selectively accumulated in the liver of the Tg mice where the CE1E2 transgene is predominantly expressed and caused liver pathology under the form of lymphocyte infiltration. The accumulation of these cells indicates a homing mechanism to this organ and a role in the development of liver pathologies. Further studies are required to unearth the mechanisms behind cellular trafficking and cell-mediated immune damage.

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Lepage, Candis. "An Evaluation of the Ottawa Hospital Viral Hepatitis Telemedicine Program and Increasing Hepatitis C Virus Care Engagement of Indigenous Peoples Through Telemedicine." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38342.

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Objective: Evaluate The Ottawa Hospital Viral Hepatitis Program (TOHVHP) telemedicine (TM) program for patient retention, treatment initiation and sustained virologic response (SVR) rates. Methods: Retrospective analysis of TOHVHP cohort data for patients entering HCV care between 2012 and 2016. Logistic regression modeling was used to assess characteristics associated with patient retention, treatment initiation, and achieving SVR. TM outcomes were compared to the standard outpatient clinic and mixed delivery outcomes. Results: Treatment initiation rates were comparable between TM and the outpatient clinic. TM delivered Direct Acting Antiviral treatments achieved high SVR outcomes across all patient populations. Patient retention was lower among TM patients. Conclusion: TOHVHP TM program engaged patients facing barriers to traditional HCV care models. Efforts to improve TM retention are needed.

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Newman, Randa E. "Hypertrophic Cardiomyopathy Genotype Prediction Models in a Pediatric Population." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459529335.

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Ekman, Jonas. "Evaluation of HCI models to control a network system through a graphical user interface." Thesis, KTH, Data- och elektroteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-208951.

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SAAB has a project under development for a network system with connected nodes, where the nodes are both information consumer and producer of different communication types. A node is an equipment or an object that are used by the army e.g. it can be a soldier, military hospital or an UAV. The nodes function as a part of a mission e.g. a mission can be Defend Gotland. The aim of this project is that the user will rank different missions from the one with the highest priority to the lowest. This will affect the network in a way that the communication between the nodes at the mission with the highest rank will be prioritised over the communication between the underlying missions. A user can via the GUI rank the missions, and then set the associated settings for them. Via the GUI the user should be able to work at three different levels. The first is to plan upcoming missions. The second one is in real time see if the system delivers the desired conditions. The last one is to simulate if the system can deliver the desired conditions. This thesis investigated various HCI models that could be used to create a GUI, to reduce the risk of a user configuring the system incorrectly. The study showed that there are no HCI models that take account for misconfigurations, and therefore a new model was created. The new model was used and evaluated by creating a prototype of a GUI for SAAB’s project and was tested on a potential user. The test showed that the new model reduced the risk of misconfigurations.
SAAB har ett projekt för utveckling av ett nätverkssystem med anslutande noder, med noder som kan vara både informationsproducent och konsument för olika kommunikationstyper. En nod är en sak eller ett objekt inom försvaret t.ex. kan det vara en soldat, militärt sjukhus eller en obemannad farkost. Varje nod tillhör ett uppdrag, tex att försvara Gotland. Målet med projektet är att man ska kunna gradera de olika uppdragen och därmed gradera vilken prioritet dessa noder har i nätet. Noder som tillhör ett uppdrag med hög gradering kommer prioriteras över de underliggande uppdragen i nätverket. En användare kan via ett grafiskt användargränssnitt gradera uppdragen och konfigurera tillhörande inställningar. Via det grafiska användargränssnittet kan en användare även planera, gradera och konfigurera inställningar för kommande uppdrag samt simulera om det går att genomföra. Användaren ska även i realtid kunna se om de önskade inställningarna inte kan leva upp till de önskade kraven, och därmed kunna åtgärda detta. Detta arbete undersökte olika MMI-modeller som kan användas för att skapa ett grafiskt användargränssnitt som minimerar risken att användaren konfigurerar systemet på ett felaktigt sätt. Studien visade sig att det inte finns några MMI modeller som tar hänsyn till felkonfigureringar, och en ny modell skapades. Den nya modellen användes och utvärderas genom att skapa en prototyp av ett grafiskt användargränssnitt för SAAB:s projekt, som testades på en potentiell användare. Testet visade att den nya modellen minskar risken för felkonfigureringar.

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Paterson, Caren Joan Isabella. "The development of a small animal model for hepatitis C virus (HCV) using chimeric HCV-BVDV (bovine viral diarrhoea virus) replicons." Thesis, Royal Veterinary College (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415668.

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Wähler, Reinhard. "Adenovirale Immuntherapie solider Tumore am HCC-Modell der Ratte (Rattus norvegicus, Berkenhout 1769)." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969478194.

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Gao, Zhanhai School of Mathematics UNSW. "Modelling Human Immunodeficiency Virus and Hepatitis C Virus Epidemics in Australia." Awarded by:University of New South Wales. School of Mathematics, 2001. http://handle.unsw.edu.au/1959.4/18187.

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This thesis is concerned with the mathematical modelling for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) epidemics in Australia. There are two parts to this thesis. Part I is aimed at modelling the transmission of HIV and HCV via needle sharing among injecting drug users (IDUs). The dynamical model of an epidemic through needle sharing among IDUs is derived. This model reveals the correlation between needle sharing and the epidemic prevalence among IDUs. The simulations of HIV and HCV prevalence and incidence among IDUs in Australia are made with this model. The comparison of simulated results with literature estimates shows that the modelled results are consistent with the literature estimates. The effects of needle sharing and cleaning on HIV and HCV prevalence and incidence among IDUs in Australia are evaluated. Part II is devoted to modelling the spread of HIV in the general community in Australia. A mathematical model is formulated to assess the epidemiological consequences of injecting drug use and sexual transmission in Australia. The effects of highly active antiretroviral therapies (HAART) on the HIV epidemic are included. The modelled results are in broad agreement with the literature estimates and observed data. The long-term effects of HAART are also discussed.

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Novosád, Jiří. "Model stárnutí unipolárního tranzistoru." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217242.

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This work deals with problems aging of unipolar transistors. In theoretical parts are described the mechanisms which causing aging unipolar transistors and way leading to the restriction the change of parameters in time. The measurement and data evaluation was built on theoretical knowledge. The model of aging FET is a result of this works; it is creating extraction of data from measured data. Finally, the degradation constants are evaluation from this data. This FET aging model is easy to use in simulators of electronics circuits including aging simulations (e.g. ELDO).

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Puttige, Anjan Rao. "Improvements on HCM Model for g-function Generation and Illustration of Fluid Temperature Prediction." Thesis, KTH, Energiteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-201032.

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Ground coupled heat pump (GCHP) is a promising solution to the problem of efficient heating/cooling of residential and commercial buildings. Long term modelling of borehole heat exchanger (BHE) is necessary for better design and operation of GCHP. The definition of the boundary condition at the borehole wall has been of particular interest in the modelling of BHE. Equal and uniform heat flux at all the borehole walls is the simplest boundary condition that is used in most analytical models and in some numerical models as well. Uniform temperature at the borehole wall with an imposed total heat flux is more accurate boundary condition since the boreholes are generally hydraulically connected in parallel and the variation of average fluid temperature is negligible along the depth of the borehole, but it is difficult to implement.This thesis presents improvements to a numerical model that uses a fictitious Highly Conductive Material (HCM) that is embedded in the boreholes is used to implement the uniform temperature boundary condition at the borehole wall. A high variation of heat flux at the ends of the borehole was observed in the HCM model. The presence of borehole resistance between the circulating fluid and the borehole wall means that the uniform fluid temperature boundary condition does not imply uniform temperature at the borehole wall. A thin thermally resistive layer was introduced between the HCM and the borehole wall to represent borehole resistance and a semi-circular part was added at the bottom of the borehole to have even distribution of heat flux. The improved model (enhanced HCM, EHCM ) was validated by comparing the g-function generated by the EHCM model with an analytical solution.The EHCM model was illustrated by simulating the operation of a monitored installation located in Baiona, Spain. The model predicted the daily average fluid temperature with reasonable accuracy in comparison with measured data. The reason for some of the inaccuracy was explained. The EHCM model was compared with other models including a commercial software.

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Helms, James W. "Developing and Evaluating the (LUCID/Star)*Usability Engineering Process Model." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/32481.

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In recent years, interactive systems developers have increasingly included usability engineering and interaction design as an integral part of software development. With recognition of the importance of usability come attempts to structure this new aspect of system design, leading to a variety of processes and methodologies. Unfortunately, these processes have often lacked flexibility, completeness and breadth of coverage, customizability, and tool support. This thesis shows the development of a process model, that we call LUCID/Star*, which addresses and overcomes the characteristics lacking in existing methodologies and an evaluation of its application in a real-world development environment. To demonstrate the goal of this thesis, we have used a combination of empirical and analytical evidence. The (LUCID/Star)* process model for usability engineering grew out of the examination, adaptation, and extension of several existing usability and software methodologies. The methods that most greatly impacted the creation of (LUCID/Star)*were the LUCID Framework of interaction design, the Star Life Cycle of usability engineering, and the Waterfall and Spiral models of Software engineering. Unlike most of these, we have found that a sequence of cycles (each of which produces a product evolution ) is a more effective analogy for the interaction development process. A sequence of cycles is more modular and makes it easier to focus on each cycle separately. Working with Optim Systems, Inc. in Falls Church, VA we instantiated the process model and introduced it as a process to develop a web-based device management system. (LUCID/Star)* performed remarkably in the Optim case, overcoming the tight constraints of budget and schedule cuts to produce an excellent prototype of the system.
Master of Science

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Finnerty, Cecilia. "Towards the development of a model of user engagement with packaged software." Thesis, London Metropolitan University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343190.

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Chau, Dueng Horng. "Data Mining Meets HCI: Making Sense of Large Graphs." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/94.

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We have entered the age of big data. Massive datasets are now common in science, government and enterprises. Yet, making sense of these data remains a fundamental challenge. Where do we start our analysis? Where to go next? How to visualize our findings? We answers these questions by bridging Data Mining and Human- Computer Interaction (HCI) to create tools for making sense of graphs with billions of nodes and edges, focusing on: (1) Attention Routing: we introduce this idea, based on anomaly detection, that automatically draws people’s attention to interesting areas of the graph to start their analyses. We present three examples: Polonium unearths malware from 37 billion machine-file relationships; NetProbe fingers bad guys who commit auction fraud. (2) Mixed-Initiative Sensemaking: we present two examples that combine machine inference and visualization to help users locate next areas of interest: Apolo guides users to explore large graphs by learning from few examples of user interest; Graphite finds interesting subgraphs, based on only fuzzy descriptions drawn graphically. (3) Scaling Up: we show how to enable interactive analytics of large graphs by leveraging Hadoop, staging of operations, and approximate computation. This thesis contributes to data mining, HCI, and importantly their intersection, including: interactive systems and algorithms that scale; theories that unify graph mining approaches; and paradigms that overcome fundamental challenges in visual analytics. Our work is making impact to academia and society: Polonium protects 120 million people worldwide from malware; NetProbe made headlines on CNN, WSJ and USA Today; Pegasus won an opensource software award; Apolo helps DARPA detect insider threats and prevent exfiltration. We hope our Big Data Mantra “Machine for Attention Routing, Human for Interaction” will inspire more innovations at the crossroad of data mining and HCI.

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Gharibpour, Sohrab, and Veronika Madzinova. "Designing for Sustainable HCI : Location-Based Mobile Application for Encouraging Environmental Friendly Ways of Transportation." Thesis, Umeå universitet, Institutionen för informatik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120738.

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This thesis aims to explore what are the main factors for designers to consider, when they design persuasive technologies for improving environmentally sustainable behavior. This paper starts out with a definition of sustainability as such, while also describing the most pressing issues within ecological sustainability. The biggest part of related research is dedicated to the persuasive technologies and three main factors of ability, trigger and motivation. We also talk about a fourth, additional factor of an emotional relationship. Besides persuasive technologies, this part describes sustainable Human-Computer Interaction, location-based services, and ethical issues are mentioned as well. The first part of the next section is dedicated to the description of a High Fidelity prototype of persuasive mobile application. The second part talks about quantitative and qualitative methods used while collecting data. After that, the reader is presented with the study results, which are then also analyzed. The following part discuss these results in a more depth. In the end, we summarize obtained results and the whole study.

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Da, Costa Daniel. "Study of cell host factors involved in Hepatitis C virus tropism." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ071/document.

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Le virus de l’hépatite C (HCV) est un problème majeur de santé publique. Le développement de nouveaux traitements pour lutter contre le HCV a été ralenti par l’absence de modèles d’études in vitro et in vivo convenables. Le but de mon travail de thèse a été, dans un premier temps, de caractériser les facteurs déterminant le tropisme hépatique du HCV. En exprimant des facteurs clés dans une lignée cellulaire humaine non-hépatocytaire, nous avons reconstitué in fine l’ensemble du cycle viral dans ces cellules. L’entrée du virus dans la cellule hôte fait intervenir différents récepteurs d’entrée dont CD81, occludin (OCLN), claudin-1 (CLDN1) et scavenger receptor class B type I (SR-BI). L’expression de ces quatre récepteurs sur cette lignée la rend hautement permissive à l’entrée du virus, mais ne permet pas de rétablir la réplication du virus. L’expression du micro-ARN 122, un micro-RNA important pour l’infection du HCV, dans les cellules exprimant les quatre récepteurs, restaure une forte réplication de l’ARN viral mais ne permet pas de détecter une production de particules infectieuses. L’expression de l’apolipoprotein E (apoE), jouant un rôle primordial dans l’assemblage et la sécrétion, rétablis cette dernière étape du cycle viral du HCV dans la lignée cellulaire humaine non-hépatocytaire. Dans un second temps, j’ai utilisé la stratégie, précédemment établie, pour étudier la spécificité d’espèce de l’infection du HCV dans plusieurs lignées hépatocytaires murines. Nous avons pu rendre ces cellules permissives à l’entrée du HCV et pu détecter une très faible réplication. L’ensemble de mes travaux apportent de nouvelles informations sur la compréhension des facteurs clés nécessaire au cycle viral du HCV dans des cellules murines et humaines
Hepatitis C virus (HCV) is a global health burden. The development of new therapeutics to treat HCV infection has been hampered by the lack of convenient in vitro and in vivo model systems. The goal of my PhD work was, in a first time, to characterize the factors determining the hepatotropism of HCV. By expressing key factors within a non-hepatic cell line, we reconstituted in fine the full HCV life cycle in those cells. Virus entry into the host cell requires different entry factors which are CD81, occludin (OCLN), claudin-1 (CLDN1) and the scavenger receptor class B type I (SR-BI). The expression of these four factors in this cell line renders it highly permissive to viral entry, but does not allow restoring replication of the virus. The expression of miR-122, a micro-RNA important for HCV infection, into the cell lines expressing the four HCV entry factors restore a strong replication of the HCV RNA but does not allow detecting infectious viral particle production. Further expression of the apolipoprotein E (apoE), which plays a critical role in the assembly and release process, restore the last step of the HCV life cycle in a non-hepatic cell line. In a second part of my PhD, I have used the previously developed strategy to study the species specificity of HCV infection using different mouse hepatoma cell lines. We have been able to render these cell lines permissive to HCV entry and have been able to detect a slight replication. Altogether, my results bring new information on the understanding of key factors important for HCV life cycle in mouse and human cells

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Essinger, Karl. "A comparison of interaction models in Virtual Reality using the HTC Vive." Thesis, Blekinge Tekniska Högskola, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-17227.

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Virtual Reality (VR) is a field within the gaming industry which has gained much popularity during the last few years. This is caused mainly by the release of the VR-headsets Oculus Rift [1] and HTC Vive [2] two years ago. As the field has grown from almost nothing in a short time there has not yet been much research done in all VR-related areas. One such area is performance comparisons of different interaction models independent of VR-hardware. This study compares the effectiveness of four software-based interaction models for a specific simple pick-and-place task. Two of the interaction models depend on the user moving a motion controller to touch a virtual object, one automatically picks them up on touch, the other requires a button press. The other two interaction models have the user move a laser pointer to point at an object to pick it up. The first has the laser pointer emitted from a motion controller and the second has it emitted from the user’s head. All four interaction models use the same hardware, the default HTC Vive equipment. The effectiveness is measured in three metrics, time to complete the task, number of errors made during the task, and the amount of participant enjoyment rated on a scale from one to five. The first two metrics are measured through an observational experiment where the application running the virtual environment also logs all relevant information. The user enjoyment is gathered through a questionnaire the participant answers during the experiment. These are the research questions: • How do the interaction models compare in terms of accuracy and time efficiency when completing basic pick and place tasks in this experiment? • Which interaction models are subjectively more enjoyable to use according to participants? The results of the experiment are displayed as charts in the results chapter and then further analysed in the analysis and discussion chapter. Possible sources of error and theories about why the results turned out the way they did are also discussed. The study concludes that the laser pointer based interaction models, 3 and 4, were much less accurate than the handheld interaction models, 1 and 2, in this experiment. All interaction models except 4 achieved about the same test duration while interaction model 4 lagged several seconds behind. The participants liked interaction model 1 the most, followed closely by 3. They disliked 4 the most and rated 2 at a point in the middle of the rest.

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Cubas, Gonzales Tania Lizeth, Alcedo Rousbel Ricardo Rondon, and Torres Fernando Mauricio Tarquino. "Best HCM deterministic model calibrated for capacity analysis of basic segments of freeways in Lima." Institute of Electrical and Electronics Engineers Inc, 2020. http://hdl.handle.net/10757/656413.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
In traffic engineering, the assessment of capacity in basic segment of freeway is a critical factor for planning, design and operational analysis of the freeway facilities. Thereby, the Highway Capacity Manual - HCM is the main guide used in many countries of the world including Perú that contain the methodology to estimate freeway capacity in traffic studies. Nevertheless, the information of vehicular traffic used for the construction of the models proposed by the HCM, reflect the characteristics of North American features. Therefore, its application in other traffic conditions, must be backed by studies of the local conditions and calibrations of the models proposed, hereby, adjusting to each city. The objetive of this research, is calibrate and compare of the HCM 2010 and HCM 2016 models, starting off the traffic engineering study in Panamericana Sur freeway located in Lima, Perú. The report will recommended the application of a calibrated model that best represents the local Peruvian conditions. The results of this study suggest that the model of calibrated capacity HCM2016, is the best representation, with a reliability of 97%, the local behavior of the basic freeway segments in function of the speed and the flow intensity. After applying the calibrated model into basic freeway segments concessioned by Rutas de Lima SAC, it was reflected that the use of the HCM2000, employed by this Company, show flow intensities within a level of service - LOS D, while, the calibrated HCM2016 shows us that those values are found, in reality, within a level of service - LOS E.

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Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;
Ph.D.
The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gastro-retentive dosage forms have been the topic of interest in recent years as a practical approach in drug deliveries to the upper GI tract or for release prolongation and absorption. These dosage forms are particularly suitable for drugs that have local effects on the gastric mucosa in the stomach. Other candidates include drugs that are likely to be absorbed in the upper small intestine, or drugs that are unstable in basic environment of distal intestine and colon or those with low solubility at elevated pH conditions (i.e. weak bases). To develop a gastro-retentive delivery system the following steps were taken. First, to investigate the possible incompatibility issues between the model drug and excipients to be used for the delivery system. Stability and physicochemical properties of the active agent and its mixture with excipients were studied using analytical techniques such as Raman spectroscopy and Differential scanning calorimetry (DSC). No incompatibility issues were detected. Second, Kollidon SR as a relatively new release-rate controlling polymer was incorporated in the final formulation. For solid dosage form the ability of the final powder mix to flow well during manufacturing and the intrinsic characteristics that make it compressible are critical. The in-depth compaction study of Kollidon SR was assessed with the help of a compaction simulator. The flowability, swelling and erosion behavior together with release-rate retarding properties of Kollidon SR were also assessed. The final oral delivery system was based on Kollidon SR and Polyethylene Oxide (PEO) 303 as a monolithic matrix system. The noneffervescent monolithic matrix was made by direct compression. In vitro evaluation of the designed system released the active content in a near zero manner. The dosage form was bouyant in pH 2.0 acidic buffer with no floatation lag time which minimizes the possibility of early gastric emptying.

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Bliemsrieder, Elisabeth [Verfasser], and Johannes [Akademischer Betreuer] Hirschberger. "Onkologische Bildgebung mittels hyperpolarisierter 13C-Magnetresonanzspektroskopie in einem Ratten-HCC-Modell / Elisabeth Bliemsrieder ; Betreuer: Johannes Hirschberger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1194835619/34.

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Soukal, Pavel. "Model stárnutí unipolárního tranzistoru." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217677.

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According to non-stopable progress in wireless communications, it is desirable to integrate the RF front-end with the baseband building blocks of communication circuits into a one chip in the recent years. The CMOS technology advances, this is the reason why it becomes attractive for system-on-a-chip implementation, but CMOS device is getting shrink, so the channel electric field increasing and the hot carrier (HCI) effect becomes more significant. If the oxide is scaled down to less than 3 nm, then there is the possibility of soft or hard oxide breakdown (S/HBD) often takes place. As a result of the oxide trapping and interface generation is the long term performance drift and related reliability problems in devices and circuits. During the scaling and increasing chip power dissipation operating temperatures for device have also is increasing. Another reliability concern is the negative bias temperature instability (NBTI) caused by the interface traps under high temperature and negative gate voltage bias are arising while the operation temperature of devices is increasing. Parameter’s extraction is a very important part of the current electronic components modeling process, as it looking for the value of the unknown parameters in mathematical model, which represents physical behavior of given electronic component. The problem of parameter extraction is that fits electronic components mathematical model to a measured data set is an ill-posed problem and its solution is inherently difficult. This diploma thesis presents the parameter extraction, optimization methodology and verifies it on a case study of a MOSFET mathematical models (LEVEL1, LEVEL2 and LEVEL3) parameter extraction. The presented nonlinear method is based on the method of the least squares, which is solved with the aid of Levenberg- Marquardt’s algorithm.

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Sandor, Ovidiu. "Social Awareness Support for Cooperation : Design Experience and Theoretical Models." Doctoral thesis, KTH, Människa-datorinteraktion, MDI, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-24482.

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This thesis addresses the research question of how social awareness support in computer systems for groups and communities can be designed in a successful way. While the field of human-computer interaction has been working with similar questions for more than 20 years, many aspects of people’s cooperation and the way those should be considered in system design still need further consideration and research. The thesis presents a number of projects where systems for cooperation have been designed for different settings and different kinds of use with a particular interest in social awareness. Drawing from the experiences of the different projects, design sensitivities around awareness, as a central prerequisite for collaboration, are suggested. Another contribution of the thesis is the presentation of a theoretical model for awareness, called Aether, introduced by us a number of years ago. We will discuss the theoretical implications of the model as well as a number of applications of it based on our own work as well as based on the work of other researchers who used Aether, by this providing confirmation of our model. Based on the findings around awareness, the thesis argues for a ‘translucent’ approach to the issue of socio-technical balance that one has to consider in the design process. Instead of trying to understand and model human behaviour or the social organization of cooperation, in order to ‘code’ them into the computer system, this approach advocates for systems that mediate information in a ‘translucent’ way so that people can retain the control of the organization of cooperation in their given context. By using a ‘reflective practitioner’ approach, the thesis discusses how people-centred methods have been used throughout these projects and looks into how awareness could be considered by using these methods. The focus of this investigation is twofold: on one hand to understand how the used methods have influenced our discussion about awareness and on the other hand it aims to address the practitioners of the field by questioning some of the common beliefs in the field. By investigating social awareness support in collaborative systems, the thesis contributes to theoretical arguments in the field of humancomputer interaction, and the area of CSCW in particular, while at the same time it provides the interaction design practitioner with a number of considerations for practical use.
QC 20100913

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Cubas, Gonzales Tania Lizeth, and Alcedo Rousbel Ricardo Rondon. "Calibración y comparación de los Manuales de Capacidad de Carreteras HCM 2000, HCM 2010 y HCM 2016; y selección de un modelo de capacidad calibrado para la aplicación en tramos básicos de la autopista Panamericana Sur de Lima Metropolitana." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/653981.

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En el área de la ingeniería del tráfico vehicular, referente a la planificación, diseño, y operación de la infraestructura vial de transporte, la mayoría de los países tienen como principal referencia la norma International Highway Capacity Manual-HCM dentro de sus políticas de operación de proyectos de transporte. Sin embargo, este manual refleja las características de tráfico estadounidense. Debido a esto, no es directamente aplicable para las distintas realidades de tráfico de los países. Por lo que, su aplicación debe estar respaldado por estudios de las condiciones locales y calibraciones de los modelos que se ajusten a cada región. Al identificar esta brecha de conocimiento, se realizó un estudio de operación de la autopista Panamericana Sur en la región de Lima-Perú. A partir de los datos de campo, se desarrollaron curvas de ajuste para calibrar los modelos de capacidad del HCM a las condiciones locales de tráfico limeñas. Como resultado de la investigación el modelo de capacidad calibrado HCM 2016, es el que mejor representa el comportamiento local de los segmentos básicos en función de la velocidad y la intensidad, con una confiabilidad del 97,41%. Finalmente, al aplicar el modelo calibrado en un tramo básico de la autopista panamericana sur concesionado por Rutas de Lima SAC, se vio reflejado que el uso del HCM 2000, empleado por esta empresa, muestran intensidades dentro de un nivel de servicio D, mientras que, el HCM 2016 calibrado nos indica que esos valores se encontrarían, en realidad, dentro de un nivel de servicio E.
In the traffic engineering, relating to the planning, design, and operation of transport infrastructure, the majority of countries have as main reference the International Standard Highway Capacity Manual-HCM within their policies of operation of transport projects. However, this manual reflects United States traffic characteristics. Because of this, it is not directly applicable for the different traffic realities of the countries. So, your application must be supported by studies of local conditions and of calibrations of the proposed models of traffic, in such a way that fits each región. Due to this knowledge gap, was made a study of the operation of the Panamericana Sur freeway located in Lima City. From this study, made it possible to develop adjustment curves to obtain capacity models calibrated to the analysis of limeñas freeway operation. The results of the research, indicates that the model calibrated HCM2016, is the best that represents the local behavior of the basic segments freeway as a function of speed and intensity, with a reliability of 97.41%. In applying the model calibrated on basic freeway segments of the Panamericana Sur concessioned by Rutas de Lima SAC, reflected that the use of the HCM2000, employed by this company, show intensities within a service level D, while, the calibrated HCM2016 indicates that these values would be actually within a service level E.
Tesis

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35

Martinez, Joao Carlos. "Anisotropie des propriétés supraconductrices du composé Y2Ba4Cu8O16." Grenoble 1, 1991. http://www.theses.fr/1991GRE10056.

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Ce travail est consacre a l'etude de l'anisotropie de hc1 et hc2 sur un meme monocristal de y2ba4cu8o16 (y:248). Nous avons montre que le compose y:248 presente une temperature de transition supraconductrice de tc0=73,2 k. Les champs critiques hc1 et hc2 sont de trois a cinq fois plus faibles par rapport au compose yba2cu3o (7-d). A partir d'un modele de ginzburg-landau anisotrope on obtient des longueurs de penetration: 1800 a (dans le plan cristallographique (a,b)) et 8000 a (au long de l'axe c). La magnetoresistance mesuree jusqu'a 20 teslas (pour differentes orientations du champ) donne des longueurs de coherence: 40 a (dans le plan (a,b)) et 4 a (au long de l'axe c). Pour h=0 et au-dessus de la temperature critique, on observe, a partir de mesures de conductivite, des fluctuations a trois dimensions. Le meme resultat a ete obtenu pour les fluctuations sous champ au-dessus de hc2, pour une temperature legerement inferieure a tc0

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Hägele, Miriam [Verfasser]. "Münchner Modell der Früherkennung und Frühen Hilfen für psychosozial hoch belastete Familien: Evaluation der Frühen Hilfen / Miriam Hägele." Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1024127044/34.

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Scheller, Tobias Philipp [Verfasser], and Sven A. [Akademischer Betreuer] Lang. "Verbesserte Wirksamkeit der FGFR Blockade durch mTOR Inhibition im HCC Modell / Tobias Philipp Scheller. Betreuer: Sven A. Lang." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1110147244/34.

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Shen, Hong. "Hepatitis C infection models." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T016.

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L'hépatite C (VHC) est l'une des causes principales de maladies du foie dans le monde, qui représentent un risque élevé d'évoluer vers la cirrhose et le carcinome hépatocellulaire. Actuellement, le traitement standard de l’infection par le VHC est l'interféron pégylé-(peg-IFN) et la ribavirine. Bien que le taux de la réponse virale soutenue (RVS) au traitement se soit améliorée au cours de ces années, cette thérapie n'est pas efficace chez tous les patients. En outre, plusieurs effets secondaires toxiques, de complications et le coût élevé limitent la compliance du patient et l'efficacité du traitement. Il n'existe pas de modèle simple d'infection par le VHC et il est nécessaire de développer des modèles in vitro et in vivo utiles pour étudier la physiopathologie de l'infection par le VHC, y compris les événements précoces de l'infection aiguë (l'entrée du virus, des mécanismes immunologiques et génétiques prédictifs) ainsi que l'évaluation de la puissance des médicaments antiviraux contre le VHC. Nous rapportons ici, nos efforts visant à développer des modèles appropriés de l'infection par le VHC. Dans un premier temps, nous avons établi un modèle de petit animal pour étudier l'infection par le VHC. Tupaia est un petit animal, apparenté aux primates et peu couteux. Dans notre travail, nous avons étudié la susceptibilité du tupaia à l'infection par VHC. Douze tupaias adultes ont été inoculés avec le VHC provenant de sérum de patient et d'ARN du VHC (génotype 1a). Trois jeunes tupaias ont été artificiellement nourris pendant un mois et ensuite inoculés par le VHC provenant de sérum du patient. L'ARN du VHC, les anticorps anti-VHC et l’évolution des quasi-espèces du VHC ont été déterminées chez l'animal avant et après l'inoculation. L'infection transitoire et intermittente s'est produite chez deux des 3 jeunes tupaias et l’infection chronique par le VHC s’est produite chez quatre tupaias sur 12 tupaias adultes. Le tupaia devrait représenter un modèle utile pour l'étude de l’infection chronique par le VHC. Dans une deuxième étape, un système de culture in vitro d'hépatocytes primaires de Tupaia a été établi, dans lequel l'infection par le VHC ne pouvait être bloquée ni par le CD81 soluble ni par des anticorps dirigés contre le CD81. Pour comprendre ces résultats, nous avons cloné, séquencé la grande boucle extracellulaire (LEL) du CD81 chez le Tupaia et analysé l'interaction de la protéine d’enveloppe E2 du VHC avec la LEL du CD81 chez le Tupaia par un test « enzyme-linked immunosorbent assay » (EIA). Nous avons constaté que chez le Tupaia, la séquence d'acides aminés du LEL de CD81 qui se lie au VHC présentait en 6 résidus d'acides aminés différents par rapport à la séquence humaine et la capacité de LEL de CD81 à se lier à la proteine d’enveloppe E2 du VHC a également diminuée. La structure différente de CD81 chez l’homme et chez le tupaia pourrait expliquer l'altération de l'interaction entre CD81 et la proteine E2 du VHC. Ce résultat démontre un rôle important de LEL du CD81 pour l'entrée du VHC. Dans une troisième étape, nous avons développé un modèle ex vivo de culture de tranches de foie humain et leur infection par le VHC. Le développement de lignées cellulaires provenant d’hepatocarcinome, permissives à la réplication du VHC, a fourni d'importants nouveaux outils virologiques pour étudier les mécanismes de l'infection par le VHC, mais ce modèle expérimental reste relativement éloigné des conditions physiologiques et pathologiques. Nous rapportons ici le développement d'un nouveau modèle ex vivo utilisant la culture de tranches de foie humain adulte, démontrant, pour la première fois, la capacité d’isolats primaires ainsi que JFH -1, H77/C3, Con1/C3 (HCVcc), de répliquer et de produire de novo des particules virales infectieuses ayant un titre viral élevé…
Hepatitis C virus (HCV) is one of the major causes of liver disease all over the world which has a high risk to progress to cirrhosis and hepatocellular carcinoma. Currently, the licensed standard treatment of HCV infection is Pegylated-interferon (peg-IFN) and ribavirin. Although the sustained viral response (SVR) rate of treatment has improved during these years, this therapy is not effective in all patients. In addition, several toxic side effects, complication and high cost limit the patient compliance and the efficacy of the treatment. There is no easy model of HCV infection and it is necessary to develop useful in vitro and in vivo models to study the pathobiology of HCV infection, including early events of acute infection (viral entry, immunological mechanisms, and genetic predictors) as well as the evaluation of the potency of the HCV antiviral drugs. We report here in our efforts in developing suitable models of HCV infection. In a first step, we preliminary established a small animal model to study HCV infection. Tupaia is a small, closed related to primate and cost-effective animal. In our work, we investigated the susceptibly of tupaia to HCV infection. Twelve adult tupaias were inoculated with native HCV from patient serum and full-length HCV RNA (Genotype 1a). Three young tupaias were artificially breeded for a month and then inoculated by native HCV from patient serum. HCV RNA, anti-HCV and HCV quasi species evolution were determined in the animal before and after inoculation. Transient and intermittent infection occurred in two among 3 young tupaias and HCV chronic infection occurred in four among 12 adult tupaias. Tupaia should represent a useful model for study HCV chronic infection. In a second step, an in vitro culture system of primary tupaia hepatocytes has been established in which HCV infection could be blocked neither by the soluble CD81 nor by antibodies against CD81. To understand these results, we cloned, sequenced the large extracellular loop (LEL) of tupaia CD81 and analyzed the interaction of HCV E2 with the tupaia CD81 LEL by enzyme-linked immunosorbent assay (EIA). We found that in the tupaia the amino acids sequence of HCV CD81 LEL presented in 6 different amino acid residues compared with human CD81 LEL sequence and the CD81 LEL ability to bind to HCV E2 was also decreased. The different structure of CD81 between human and tupaia could explain the alteration of the interaction between HCV E2 and CD81. This result demonstrated an important role of CD81 LEL for HCV entry. In a third step, we developed an ex vivo model of human liver slices culture and their infection with HCV. The development of human cultured HCV-replication-permissive hepatocarcinoma cell lines has provided important new virological tools to study the mechanisms of HCV infection; however this experimental model remains distantly related to physiological and pathological conditions. Here, we report the development of a new ex vivo model using human adult liver slices culture, demonstrating, for the first time, the ability of primary isolates to undergo de novo viral replication with the production of high titer infectious virus, as well as JFH-1, H77/C3, Con1/C3 (HCVcc). This experimental model was validated by demonstrating the HCV neutralization or HCV inhibition, in a dose-dependent manner, either by CD81 or E2 specific antibodies or convalescent serum from a recovered HCV patient, or by anti-viral drugs. This new ex vivo model represents a powerful tool for studying the viral life cycle, dynamics of virus spread in the liver and also for evaluating the efficacy of the new antiviral drugs. In the last step, we evaluated the efficacy of the new antiviral drugs with our ex vivo model of human adult liver slices. HCV NS3/4A protease is essential for viral replication and has been one of the most important target for developing specific antiviral drug

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Soare, Catalina P. "Characterization of Liver Damage Mechanisms Induced by Hepatitis C Virus." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20343.

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Hepatitis C Virus (HCV) is one of the most important causes of chronic liver disease, affecting more than 170 million people worldwide. The mechanisms of hepatitis C pathogenesis are unknown. Viral cytotoxicity and immune mediated mechanisms might play an important role in its pathogenesis. HCV infection and alcohol abuse frequently coexist and together lead to more rapid progression of liver disease, increasing the incidence and prevalence of cirrhosis and hepatocellular carcinoma. The cytopathic effect of HCV proteins, especially the core, E1 and E2 structural proteins, which induce liver steatosis, oxidative stress and cell transformation may be amplified by alcohol abuse. The purpose of this study was to characterize the liver damage mechanisms induced by HCV structural proteins and alcohol and to determine the potential molecular mechanism(s) that may promote chronic, progressive liver damage. A transgenic mouse model expressing HCV core, E1 and E2 was used to investigate whether alcohol increased HCV RNA expression. Real-time RT-PCR analysis of genes involved in lipid metabolism and transport confirmed their abnormal expression in the alcohol-fed transgenic mice. In addition, light and electron microscopy analysis were performed on liver tissues of transgenic mice on an alcoholic diet versus those on a normal diet, in order to identify histological changes. The severe hepatopathy in HCV transgenic mice was exacerbated by alcohol. Mitochondria and endoplasmic reticulum had severe abnormalities in the electron microscopy analysis. The second part of this study focused on adaptive immune responses, which may also play an important role in HCV pathogenesis. I focused my analysis on dendritic cells (DC), which have been the main suspects to explain immune impairment in HCV infection. Their powerful antigen-presenting function allows them to stimulate the antiviral response of CD4+ and CD8+ T cells, the effector cells of the immune system. This unique function of the DC makes them possible targets for immune evasion by the Hepatitis C virus. In this study, DCs were generated from mouse bone marrow cells. I investigated their maturation capacity in the presence of structural proteins of HCV. The impact of HCV core/E1/E2 polyprotein on DCs cytokine expression and ability to activate T-cell lymphocytes was also analyzed. A dysfunctional CD4 T cell response was observed after exposure of DCs to core/E1/E2 polyprotein, indicating inefficient CD4 priming, which might lead to chronic HCV infection in humans. The presence of the core/E1/E2 polyprotein reduced the DC maturation capacity and the expression of certain cytokines (IL-12, IFNg, IL-6, MCP-1) important for stimulation and chemotaxis of T cells and other immune cells. My studies contribute to the understanding of HCV pathogenesis and may have implications to the development of better therapies for HCV infection.

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Albalawi, Tahani F. "Quantifying the Effect of Cognitive Biases on Security Decision-Making." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532529752353789.

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Kitkowska, Agnieszka. "Advancing Models of Privacy Decision Making : Exploring the What & How of Privacy Behaviours." Licentiate thesis, Karlstads universitet, Institutionen för matematik och datavetenskap (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69974.

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People's decisions do not happen in a vacuum; there are multiple factors that may affect them. There are external determinants, such as cost/benefit calculation of decision outcomes. There are also internal factors, such as attitudes, personality, emotions, age, and nationality. Frequently, the latter have a final say on the decision at hand, and similar determinants are triggered during the digital interaction when people make decisions about their privacy. The current digital privacy landscape is filled with recurring security breaches and leaks of personal information collected by online service providers. Growing dependency on Internet-connected devices and increasing privacy risks prompted policy makers to protect individuals' right to privacy. In Europe, the General Data Protection Regulation requires companies to provide adequate information about their data collection and processing practices to users, to increase privacy awareness and enable better decision making. Regardless, currently there is no sufficient, usable technology, which could help people make improved privacy decisions, decreasing over-disclosure and oversharing. Hence, multidisciplinary researchers aim at developing new privacy-enhancing solutions. To define such solutions and successfully convey data provision and processing practices, potential risks, or harms resulting from information disclosure, it is crucial to understand cognitive processes underpinning privacy decisions. In this thesis, we examine privacy decisions and define factors that influence them. We investigate the attitude-behaviour relationship and identify privacy concerns affecting perceptions of privacy. Additionally, we examine factors influencing information sharing, such as emotional arousal and personality traits. Our results demonstrate that there is a relationship between privacy concerns and behaviours, and that simplified models of behaviour are insufficient to predict privacy decisions. Our findings show that internal factors, such as nationality and culture, emotional arousal, and individual characteristics, affect privacy decisions. Based on our findings, we conclude that future models of privacy should incorporate such determinants. Further, we postulate that privacy user interfaces must become more flexible and personalised than the current solutions.
Growing dependency on Internet-connected devices and increasing privacy risks prompted policymakers to protect individuals’ right to privacy. In Europe, the General Data Protection Regulation requires companies to provide users with adequate information about data collection and processing practices to increase privacy awareness and enable better decisions. Hence, multidisciplinary researchers aim at developing new privacy-enhancing solutions. However, to develop such solutions it is crucial to understand cognitive processes underpinning privacy decisions. This thesis objective is to investigate privacy behaviours. We identify privacy concerns affecting perceptions of privacy and examine factors influencing information sharing. We show that simplified models of behaviour are insufficient predictors of privacy decisions, and that demographic characteristic, emotion and personality affect privacy attitudes and behaviours. Based on our findings we conclude that future models of privacy and designs of privacy user interfaces must incorporate such behavioural determinants.

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Thavamani, Abhishek [Verfasser], and Alfred [Akademischer Betreuer] Nordheim. "Integrated multi-omic analysis of HCC formation in the SRF-VP16iHep mouse model / Abhishek Thavamani ; Betreuer: Alfred Nordheim." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1173699864/34.

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Kraus, Florian [Verfasser]. "Verfahren zur weitgehend automatisierten Erzeugung der Middleware für hoch ausfallsichere, integrierte Avioniksysteme mittels Model-Integrated Computing / Florian Kraus." München : Verlag Dr. Hut, 2018. http://d-nb.info/1170473504/34.

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Zacharias, Stefan [Verfasser], Michael [Akademischer Betreuer] Kerschgens, and Susanne [Akademischer Betreuer] Crewell. "Energiehaushalte aus Flugzeugmessungen und hoch aufgelösten Simulationen mit dem meteorologischen Modell FOOT3DK / Stefan Zacharias. Gutachter: Michael Kerschgens ; Susanne Crewell." Köln : Universitäts- und Stadtbibliothek Köln, 2011. http://d-nb.info/1038110386/34.

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Kerkmann, Heiko [Verfasser]. "Modell und Berechnung von Konzentrations-Inhibitionskurven hoch- und niedrigpotenter Substanzen am TTX-resistenten Natriumkanal der erwachsenen Ratte / Heiko Kerkmann." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1065394853/34.

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Shimaoka, Filipe Jun. "Avaliação da força de compressão dos parafusos sem cabeça (HCS) - modelo experimental de fraturas do escafoide em ossos sintéticos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17142/tde-22082017-101735/.

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A força de compressão entre os fragmentos é um importante fator que interfere na consolidação das fraturas. O objetivo deste trabalho foi avaliar a eficácia de cada um dos parafusos sem cabeça de auto compressão com três diâmetros de rosca diferentes, empregados no tratamento das fraturas do escafoide. Utilizando um dispositivo de alumínio acoplado à uma máquina universal de ensaios equipada com uma célula de carga de 50 kgf. Foram utilizados dois blocos de espuma rígida de poliuretana de densidade 0,16 g/cc. Os testes foram realizados com os parafusos HCS da marca Synthes®, com diâmetros de 3,0 mm, 2,4 mm e 1,5 mm. Todos tinham 20 mm de comprimento. Os parafusos foram introduzidos utilizando os princípios da técnica AO, sendo o instrumental fornecido com os parafusos. Foram realizados com os parafusos supracitados fixações com inserção a 90º, 60º, 45º e 30º de inclinação em relação à superfície do bloco. Todos procedimentos foram repetidos por sete vezes, comparando-se os valores obtidos do pico da força de compressão (Força Max), da força de compressão após 20 segundos (Força T1) e da força de compressão após 300 segundos (Força T2). Para as fixações dos parafusos de 3.0 mm e 2.4 mm com 30º de inclinação não houve compressão, devido ao rompimento da superfície do bloco pela rosca da extremidade proximal dos parafusos. A Força Max do parafuso HCS de 3.0 mm foi maior do que a dos parafusos de 2.4 mm em todas as comparações. A relação entre as Força T2/Força T1 foram semelhante em todas as comparações, isto é, não apresentaram diferença estatística, e demostraram que a acomodação dos parafusos não foi relacionada ao diâmetro da rosca dos parafusos. Concluímos que a força de compressão entre os fragmentos foi maior quando o diâmetro da rosca do parafuso também foi maior, independente da posição da inserção em relação à fratura
The interfragmentary compression force is an important factor for fracture healing. The aim of this study was to evaluate the effectiveness of each three different diameters headless compression screw, used for the treatment of scaphoid fractures. It was used an aluminum device coupled to a universal testing machine equipped with a load cell of 50 kgf. Two rigid foam blocks made of polyurethane with density of 0.16 g/cc. The tests were performed with the HCS Synthes® with 20 mm length 3.0 mm, 2.4 mm and 1.5 mm in diameter. The screws were inserted using the AO technique and instrumental provided with screws. They were performed with the above screw with 90º, 60º, 45º and 30º tilt with the block and repeated seven times and comparing the results obtained from the peak compression force (Max Force) to compression force after 20 seconds (T1 Force) and compression force after 300 seconds (T2 force). For the fixations of 3.0 mm and 2.4 mm screws with 30° tilt no compression were reached, as the proximal threads of the screws broke the surface of the block. Max Force for HCS 3.0 mm was higher than the 2.4 mm screws in all comparisons. The relationship T2 Force / T1 Force was similar in all comparisons, showing no statistical difference, proving that the accommodation of the screws is not related to the threads diameter of the screws. It was concluded in this work that there was a reduction of interfragmentary compressive force by reducing the threads diameter of the screws, regardless of the position placed over the fracture surface

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Azizi, Ali. "Humoral and cellular immune responses in RNA viral infections: Immunogenicity of HIV-1, HCV and SARS-CoV candidate vaccines in animal models." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/29278.

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It is difficult to induce protective immunity against most RNA viruses. However, there is strong evidence that humoral and especially cellular immune responses play crucial roles in the control of established RNA viral infections. Thus, an ideal vaccine should be able to induce strong specific antibody titer as well as a robust T-helper and T-cell cytotoxic response. Here, correlates of protective immunity against HIV-1, HCV and SARS-CoV were assessed. Monocistronic and polycistronic DNA constructs containing structural HIV-l, and SARS genes were designed. The structural proteins (HIV- gpl20, gag, pol, HCV-core, E1/E2 and SARS-NC) were also expressed, purified and characterized in mammalian and bacterial cell lines. HLA-A2.1 and B6 mice were immunized with different combinations of DNA constructs, recombinant proteins and novel adjuvants. Humoral responses were measured by titrating of specific antibodies and cell-mediated immune responses were identified by Th1/Th2 cytokine expression, lymphocyte proliferation, intracellular cytokine staining, HLA-peptide dimer assay, and ELISPOT. The first study in HIV-1 showed that a combination of DNA single constructs, protein and adjuvant induce a higher immune response compared to the DNA or/and protein alone. In the second HIV-1 approach, a synergistic effect between HIV/HCV antigens was detected that may lead to induction of multi-specific immune responses against both HIV and HCV. In the third study (SARS project), a high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP (X-link inhibitor of apoptosis) as an adjuvant.

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Chen, Jinyan, and 陈锦艳. "Residual risks estimating models of transmission of HBV, HIV and HCV with different assays : lesson for screening strategies for Chinese blood banks." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193767.

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Blood safety is an issue of public health concern. Sensitive screening assays for excluding infectious donations have been widely adopted to reduce the risk of transfusion-transmitted infections, especially for hepatitis B virus (HBV), hepatitis C virus (HCV) and (human immunodeficiency virus) HIV infections. Even with sensitive screening assays, residual risk of undetectable infectious donations remains because donations may be made in the “window period” when the infection is present but difficult to detect with serological tests. Currently, serological screening tests are mainly used in China, rather than the more expensive and sensitive DNA based tests. From a public health perspective, choice of the screening test depends on overall cost-effectiveness, including assessment of the residual risk. To facilitate a full cost-effectiveness analysis, this review identifies the best residual risk estimating model in a Chinese setting. The search was conducted using databases including PubMed and ISI Web of Knowledge filtered by publication date, English language and accessibility of full text. Both exclusion and inclusion criteria were used for articles identification. Five papers on residual model estimation were retrieved. The blood donor profile in China was used to understand how these models differ and how these differences would affect their use and interpretation. This study identified the Michael P. Busch model as the optimal residual risk estimating model for Chinese blood banks’ to facilitate the cost-effectiveness assessment of a screening strategy in terms of achieving a balance of blood safety and cost.
published_or_final_version
Public Health
Master
Master of Public Health

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Niu, Zhuolu [Verfasser], and Martin [Akademischer Betreuer] Biel. "Biochemical and functional analysis of a genetic mouse model with altered HCN channel expression / Zhuolu Niu ; Betreuer: Martin Biel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/113104052X/34.

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Taei, Nasrin. "Synthetic Peptides Model Instability of Cardiac Myosin Subfragment-2." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc283844/.

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Hypertrophic cardiomyopathy (HCM), a heart-related abnormality, is the most prevalent cause of sudden death in young athletes at sporting events. A cluster of cardiomyopathy mutations are localized in β-cardiac myosin at the N-terminal region of subfragment-2. Using resonance energy transfer probes, a synthetic peptide model system was developed to study stability of the coiled coil (S2 fragment) structure by determining monomer-dimer equilibrium of the peptide. Fluorescence resonance energy transfer and MacroModel software suite were used to obtain distance measurements along with measurement of coiled coil formation. The model peptide was used to characterize the effects of disease-causing-mutations and examine potential candidate drugs (polyamines) to counteract effects of mutations causing HCM. Distance measurements between donor and acceptor probes obtained by computational simulation and fluorescence resonance energy transfer (FRET) were consistent. Measurements also agreed with simulations of unlabeled wildtype, indicating coiled coil structural stability of the peptide. Interaction of the site-specific antibody with the peptide strongly inhibited dimerization and destabilized coiled coil structure of the peptide. Presence of negatively charged glutamate residues in the region of subfragment-2 strongly suggested a potential interaction site for positively charged polyamines. Binding of certain polyamines, such as poly-L-Lysine 11 residues and poly-D-Lysine 17 residues, demonstrated the ability to enhance dimerization and improve stability of the coiled coil structure, while some other polyamines were shown to have insignificant impact on the structure. In an attempt to characterize the effect of HCM-causing-mutations, peptides containing E924K mutation and lethal mutation E930 deletion were synthesized. Fluorescence resonance probes were conjugated to the mutant peptides to determine coiled coil formation. Results obtained from both dynamic simulations and resonance energy transfer experiments indicated that these mutations strongly inhibit dimerization, and thus, destabilize coiled coil structure of the peptide. Further experiments were conducted using heterodimers containing a chain of wildtype and a chain of mutant peptide. Both E924K & Edel930 mutations destabilized coiled coil formation and prevented dimerization. This peptide model system would provide a promising tool for drug development targeting HCM-causing-mutations along the S2 region of myosin.

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Dissertations / Theses on the topic 'HCh models'

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