Relevant bibliographies by topics / HBMS4

Academic literature on the topic 'HBMS4'

Author: Grafiati
Published: 25 July 2024

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Journal articles on the topic "HBMS4"

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Xu, Cynthia M., Catherine Karbasiafshar, Rayane Brinck Teixeira, Nagib Ahsan, Giana Blume Corssac, Frank W. Sellke, and M. Ruhul Abid. "Proteomic Assessment of Hypoxia-Pre-Conditioned Human Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Demonstrates Promise in the Treatment of Cardiovascular Disease." International Journal of Molecular Sciences 24, no. 2 (January 14, 2023): 1674. http://dx.doi.org/10.3390/ijms24021674.

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Human bone marrow mesenchymal stem cell derived-extracellular vesicles (HBMSC-EV) are known for their regenerative and anti-inflammatory effects in animal models of myocardial ischemia. However, it is not known whether the efficacy of the EVs can be modulated by pre-conditioning of HBMSC by exposing them to either starvation or hypoxia prior to EV collection. HBMSC-EVs were isolated following normoxia starvation (NS), normoxia non-starvation (NNS), hypoxia starvation (HS), or hypoxia non-starvation (HNS) pre-conditioning. The HBMSC-EVs were characterized by nanoparticle tracking analysis, electron microscopy, Western blot, and proteomic analysis. Comparative proteomic profiling revealed that starvation pre-conditioning led to a smaller variety of proteins expressed, with the associated lesser effect of normoxia versus hypoxia pre-conditioning. In the absence of starvation, normoxia and hypoxia pre-conditioning led to disparate HBMSC-EV proteomic profiles. HNS HBMSC-EV was found to have the greatest variety of proteins overall, with 74 unique proteins, the greatest number of redox proteins, and pathway analysis suggestive of improved angiogenic properties. Future HBMSC-EV studies in the treatment of cardiovascular disease may achieve the most therapeutic benefits from hypoxia non-starved pre-conditioned HBMSC. This study was limited by the lack of functional and animal models of cardiovascular disease and transcriptomic studies.
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Cho, Hee-Yeon, Sooho Lee, Ji-Hong Park, Yoon Hae Kwak, HaeYong Kweon, and Dongchul Kang. "Competitive Hybridization of a Microarray Identifies CMKLR1 as an Up-Regulated Gene in Human Bone Marrow-Derived Mesenchymal Stem Cells Compared to Human Embryonic Fibroblasts." Current Issues in Molecular Biology 44, no. 4 (March 28, 2022): 1497–512. http://dx.doi.org/10.3390/cimb44040102.

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Mesenchymal stem cells (MSCs) have been widely applied to the regeneration of damaged tissue and the modulation of immune response. The purity of MSC preparation and the delivery of MSCs to a target region are critical factors for success in therapeutic application. In order to define the molecular identity of an MSC, the gene expression pattern of a human bone marrow-derived mesenchymal stem cell (hBMSC) was compared with that of a human embryonic fibroblast (hEF) by competitive hybridization of a microarray. A total of 270 and 173 genes were two-fold up- and down-regulated with FDR < 0.05 in the hBMSC compared to the hEF, respectively. The overexpressed genes in the hBMSC over the hEF, including transcription factors, were enriched for biological processes such as axial pattern formation, face morphogenesis and skeletal system development, which could be expected from the differentiation potential of MSCs. CD70 and CD339 were identified as additional CD markers that were up-regulated in the hBMSC over the hEF. The differential expression of CD70 and CD339 might be exploited to distinguish hEF and hBMSC. CMKLR1, a chemokine receptor, was up-regulated in the hBMSC compared to the hEF. RARRES2, a CMKLR1 ligand, stimulated specific migration of the hBMSC, but not of the hEF. RARRES2 manifested as ~two-fold less effective than SDF-1α in the directional migration of the hBMSC. The expression of CMKLR1 was decreased upon the osteoblastic differentiation of the hBMSC. However, the RARRES2-loaded 10% HA-silk scaffold did not recruit endogenous cells to the scaffold in vivo. The RARRES2–CMKLR1 axis could be employed in recruiting systemically delivered or endogenous MSCs to a specific target lesion.
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Sun, Aining, Guo Feng, Jingjing Xu, Wenjuan Wang, and Wu Depei. "The Involvement of NF-κB Subunits in the Interaction Between CLL-B Cells and Bone Marrow Stromal Cells." Blood 118, no. 21 (November 18, 2011): 4590. http://dx.doi.org/10.1182/blood.v118.21.4590.4590.

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Abstract Abstract 4590 Objective: To investigate the function of NF-κB signaling pathway in the interaction between chronic lymphocytic leukemia B cells and bone marrow stromal cells. Method: The expression of NF-κB family members at mRNA and protein levels were examined by quantitative RT-PCR and Western bloting analyses individualy, and the differences between CLL-human bone marrow stromal cell (hBMSC) and non-CLL-hBMSC were investigated with the methods above. Cell death was measured by flow cytometry analysis after B-CLL cells were co-cultured with hBMSC and treated with proteasome inhibitors. The changes of NF-κB expression at the protein levels were examined by Western bloting after co-culture experiment. Result: The expression of NF-κB family members turned out to be heterogeneous at both mRNA and protein levels in B-CLL cells, and the members demonstrated a different κB-DNA binding activities. The mRNA expression of NF-κB family members in B-CLL cells was shown at a remarkable higher level than that of the controls. The relative mRNA expression of relA was 0.0214±0.012, whereas it was 0.0130±0.012 for the controls of CD19 positive cells. The relative mRNA expression of p50 and p52 were 66.0860±21.649 and 0.0208±0.011 respectively, and the corresponding expression of CD19 positive cells were 24.8440±9.749 and 0.0065±0.002. The differences were statistically significant. There was no notable difference between CLL-hBMSC and Non-CLL-hBMSC. hBMSC protected B-CLL cells against the proteasome inhibitors and facilitated the survival of B-CLL cells. Conclusion: NF-κB expression is heterogeneous in bone marrow B-CLL cells. There is no significant difference between CLL-hBMSC and non-CLL-hBMSC. hBMSC can protect the survival of B-CLL cells dependending on the endogenous NF-κB activity. hBMSC can increase the drug resistance of B-CLL cells to proteasome inhibitors. Disclosures: No relevant conflicts of interest to declare.
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Yang, Hongwei, Meng Cong, Weixiao Huang, Jin Chen, Min Zhang, Xiaosong Gu, Cheng Sun, and Huilin Yang. "The Effect of Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Cartilage Repair in Rabbits." Stem Cells International 2022 (September 8, 2022): 1–12. http://dx.doi.org/10.1155/2022/5760107.

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Mesenchymal stem cells (MSCs) have shown chondroprotective effects in cartilage repair. However, side effects caused by MSC treatment limit their application in clinic. As a cell-free therapy, MSC-derived exosomes (EXOs) have attracted much more attention in recent years. In the present study, we prepared EXOs from human bone marrow mesenchymal stem cells (hBMSCs) and examined their therapeutic potentials in cartilage repair. Our results showed that the prepared extracellular vesicles exhibit classical features of EXOs, such as cup-like shape, around 100 nm diameter, positive protein markers (CD81, TSG101, and Flotillin 1), and ability of internalization. In primary chondrocytes, the treatment of hBMSC-EXOs markedly increases cell viability and proliferation in a dose-dependent manner. Moreover, wound healing assay showed that hBMSC-EXOs accelerate cell migration in primary chondrocytes. JC-1 staining revealed that the mitochondrial membrane potential was enhanced by hBMSC-EXOs, indicating cell apoptosis was decreased in the presence of hBMSC-EXOs. In rabbits with articular cartilage defects, local administration with hBMSC-EXOs facilitates cartilage regeneration as evidenced by gross view and hematoxylin-eosin (H&E) and Saf-O/Fast Green staining. In addition, the International Cartilage Repair Society (ICRS) score was increased by the application of hBMSC-EXOs. Overall, our data indicate that the treatment with hBMSC-EXOs is a suitable cell-free therapy for treating cartilage defects, and these benefits are likely due to improved cell proliferation and migration in chondrocytes.
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Chikato, Masao Koda, Koshiro Kamiya, Mari Dezawa, Masayuki Hashimoto, Takeo Furuya, Akihiko Okawa, Kazuhisa Takahashi, and Masashi Yamazaki. "Transplantation of human bone marrow stromal cell-derived neuroregenrative cells promotes functional recovery after spinal cord injury in mice." Acta Neurobiologiae Experimentalis 74, no. 4 (December 31, 2014): 479–88. http://dx.doi.org/10.55782/ane-2014-2010.

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Transplantation of bone marrow stromal cells (BMSCs) for spinal cord injury (SCI) has been shown to improve functional outcome. BMSCs can be easily obtained from bone marrow aspirate and have fewer problems in the clinical application for human SCI from the ethical and legal points of view. Recently, we produced cells with neural stem and/or progenitor cell property and neural regeneration supporting capacity from human bone marrow stromal cells (human bone marrow stroma cell-derived neuroregenerative cells: hBMSC-NRs). The aim of the present study was to clarify the effectiveness of transplantation of hBMSC-NRs to injured spinal cord of severe combined immunodeficiency (NOD/SCID) mice. Neurite outgrowth assay of PC-12 cells was performed. One week after a T9-level contusion SCI, hBMSCs or hBMSC-NRs were transplanted into the spinal cord. After the transplantation, functional and histological examinations were performed. Conditioned media of hBMSC-NRs significantly promoted the neurite outgrowth of PC-12 cells in vitro. Transplanted hBMSC-NRs survived in the injured spinal cord 8 weeks after SCI. Immunohistochemistry revealed that the density of serotonin-positive fibers of the transplanted group was significantly higher than that of the control group at the epicenter and caudal segment to the injured site. The recovery of hind limb function of the hBMSC-NRs group was significantly better than that of the control group. In conclusion, hBMSC-NRs can be one of the realistic candidates for cell transplantation therapy for human SCI.
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Tam, Kin-Wai, Cheuk-Yin Wong, Kenneth Lap-Kei Wu, Guy Lam, Xiaotong Liang, Wai-Ting Wong, Maximilian Tak-Sui Li, et al. "IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries." Cells 12, no. 11 (May 25, 2023): 1479. http://dx.doi.org/10.3390/cells12111479.

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The in vitro derivation of Schwann cells from human bone marrow stromal cells (hBMSCs) opens avenues for autologous transplantation to achieve remyelination therapy for post-traumatic neural regeneration. Towards this end, we exploited human induced pluripotent stem-cell-derived sensory neurons to direct Schwann-cell-like cells derived from among the hBMSC-neurosphere cells into lineage-committed Schwann cells (hBMSC-dSCs). These cells were seeded into synthetic conduits for bridging critical gaps in a rat model of sciatic nerve injury. With improvement in gait by 12-week post-bridging, evoked signals were also detectable across the bridged nerve. Confocal microscopy revealed axially aligned axons in association with MBP-positive myelin layers across the bridge in contrast to null in non-seeded controls. Myelinating hBMSC-dSCs within the conduit were positive for both MBP and human nucleus marker HuN. We then implanted hBMSC-dSCs into the contused thoracic cord of rats. By 12-week post-implantation, significant improvement in hindlimb motor function was detectable if chondroitinase ABC was co-delivered to the injured site; such cord segments showed axons myelinated by hBMSC-dSCs. Results support translation into a protocol by which lineage-committed hBMSC-dSCs become available for motor function recovery after traumatic injury to both peripheral and central nervous systems.
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Ramalingam, Mahesh, Sujeong Jang, and Han-Seong Jeong. "Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis." Stem Cells International 2021 (January 22, 2021): 1–16. http://dx.doi.org/10.1155/2021/6658271.

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Mesenchymal stem cells (MSCs) have been used against several diseases. Their potential mainly appears from its secreted biomolecules. Human bone marrow-derived stem cells (hBMSC) displayed neuronal functional characteristics after differentiation by basic fibroblast growth factor (bFGF) and forskolin. PD is a chronic age-related neurodegenerative disease (NDD) characterized by loss of dopaminergic neurons in the substantia nigra (SN) and abnormal accumulation of α-synuclein (α-syn) aggregations. In this present study, we evaluated the therapeutic effects of neural differentiated hBMSC (NI-hBMSC) conditioned medium (NI-hBMSC-CM) to a rotenone- (ROT-) induced Parkinson’s disease (PD) model in SH-SY5Y cells. NI-hBMSC-CM treatment (50% diluted) in the last 24 h of 48 h ROT (0.5 μM) toxicity showed a significant increase in cell survival. The decreased tyrosine hydroxylase (TH) expression as a hallmark of PD was increased by NI-hBMSC-CM. The Triton X-100-soluble and Triton X-100-insoluble cell lysate fractions were used in Western blotting. The oligomeric, dimeric, and monomeric phosphorylated serine129 (p-S129) α-syn and total monomeric α-syn were decreased during ROT toxicity in the Triton X-100-soluble fraction. The Triton X-100-insoluble fraction revealed that ROT toxicity significantly increased the oligomeric but decreased the dimeric and monomeric p-S129 α-syn expressions while all forms of total α-syn were increased in SH-SY5Y cells. NI-hBMSC-CM stabilized the physiological α-syn monomers and reduced aggregated insoluble p-S129 α-syn against ROT. The cytoskeletal proteins, neurofilament-H (NF-H), β3-tubulin (Tuj1), neuronal nuclei (NeuN), and synaptophysin (SYP) were significantly decreased during ROT toxicity. In addition, proapoptotic Bax was increased by ROT with decreased antiapoptotic Bcl-2 and Mcl-1 as well as proforms of caspase-9, caspase-3, caspase-7, and PARP-1. NI-hBMSC-CM ameliorated the neurotrophic protein expressions, controlled the Bax/Bcl-2 ratio, upregulated procaspases, and inactivated PARP-1. From our results, we conclude that NI-hBMSC-CM containing released biomolecules during neural differentiation employs regenerative effects on the ROT model of PD in SH-SY5Y cells.
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Wang, Baodong, Na Xu, Li Cao, Xiaojun Yu, Shanxi Wang, Qikun Liu, Yinguang Wang, Haoran Xu, and Yang Cao. "miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/β-Catenin Pathway." Stem Cells International 2022 (October 20, 2022): 1–16. http://dx.doi.org/10.1155/2022/2164057.

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In this study, we explored the regulatory mechanism of intervertebral disc degeneration (IDD) that involves miR-31 shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) and its downstream signaling molecules. Nucleus pulposus cells (NPCs) were isolated and treated with TNF-α to simulate IDD in vitro. The TNF-α-exposed NPCs were then cocultured with hBMSCs or hBMSC-EVs in vitro to detect the effects of hBMSC-EVs on NPC viability, apoptosis, and ECM degradation. Binding between miR-31 and NFAT5 was determined. A mouse model of IDD was prepared by vertebral disc puncture and injected with EVs from hBMSCs with miR-31 knockdown to discern the function of miR-31 in vivo. The results demonstrated that hBMSC-EVs delivered miR-31 into NPCs. hBMSC-EVs enhanced NPC proliferation and suppressed cell apoptosis and ECM degradation, which was associated with the transfer of miR-31 into NPCs. In NPCs, miR-31 bound to the 3 ′ UTR of NFAT5 and inhibited NFAT5 expression, leading to activation of the Wnt/β-catenin pathway and thus promoting NPC proliferation and reducing cell apoptosis and ECM degradation. In addition, miR-31 in hBMSC-EVs alleviated the IDD in mouse models. Taken together, miR-31 in hBMSC-EVs can alleviate IDD by targeting NFAT5 and activating the Wnt/β-catenin pathway.
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Zhang, Zhen, Yi Liu, Xuelian Tao, Ping Du, Myagmartsend Enkhbat, Khoon S. Lim, Huaiyu Wang, and Peng-Yuan Wang. "Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin/Hyaluronan Hydrogels." Polymers 15, no. 8 (April 18, 2023): 1925. http://dx.doi.org/10.3390/polym15081925.

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Cell cultures of dispersed cells within hydrogels depict the interaction of the cell–extracellular matrix (ECM) in 3D, while the coculture of different cells within spheroids combines both the effects of cell–cell and cell–ECM interactions. In this study, the cell co-spheroids of human bone mesenchymal stem cells/human umbilical vein endothelial cells (HBMSC/HUVECs) are prepared with the assistance of a nanopattern, named colloidal self-assembled patterns (cSAPs), which is superior to low-adhesion surfaces. A phenol-modified gelatin/hyaluronan (Gel-Ph/HA-Ph) hydrogel is used to encapsulate the multicellular spheroids and the constructs are photo-crosslinked using blue light. The results show that Gel-Ph/HA-Ph hydrogels with a 5%-to-0.3% ratio have the best properties. Cells in HBMSC/HUVEC co-spheroids are more favorable for osteogenic differentiation (Runx2, ALP, Col1a1 and OPN) and vascular network formation (CD31+ cells) compared to HBMSC spheroids. In a subcutaneous nude mouse model, the HBMSC/HUVEC co-spheroids showed better performance than HBMSC spheroids in angiogenesis and the development of blood vessels. Overall, this study paves a new way for using nanopatterns, cell coculturing and hydrogel technology for the generation and application of multicellular spheroids.
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Choi, Andrew, Hyungjun Yoon, Seon Jin Han, Ji-Ho Lee, In Hyeok Rhyou, and Dong Sung Kim. "Rapid harvesting of stem cell sheets by thermoresponsive bulk poly(N-isopropylacrylamide) (PNIPAAm) nanotopography." Biomaterials Science 8, no. 19 (2020): 5260–70. http://dx.doi.org/10.1039/d0bm01338b.

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A novel concept of utilizing bulk PNIPAAm substrate nanotopography for rapid harvest of human bone marrow mesenchymal stem cells (hBMSCs) sheet. The created nanotogporaphy significantly accelerated the formation of hBMSC layers and eased the detachment of hBMSC sheets.
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Dissertations / Theses on the topic "HBMS4"

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Mishra, Ekant. "Concussions in Ice Hockey : Accident Reconstructions Using Finite Element Simulations." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-253774.

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Ice hockey, one of the most popular sports in the world, is a contact sport that is always associated with huge risks of traumatic brain injuries (TBIs) resulting from high-velocity impacts. Although technology in player protection equipment has advanced over the years, mild traumatic brain injuries (mTBIs) like concussion remain prevalent. Finite Element (FE) analysis presents a methodology to recreate accidents in an effort to study the effects of protective helmets and predict brain injuries. This study aimed at improving the response of an existing ice hockey helmet FE model during different impact conditions and reconstructing an ice hockey collision using FE simulations. First, the shear response of the Expanded Polypropylene (EPP) material for the helmet liner was improved by means of a single element simulation to replicate the experiments. Simulations of helmet drop tests were then performed to validate the helmet FE model. Two different designs of the helmet model were implemented, one with normal properties of the foam and the other with a softer foam. Actual cases of ice hockey accidents were then reconstructed using positioning and impact velocities as input from video analysis. As player to player collisions had not been reconstructed for ice hockey using two player models, it was decided to use two full body Human Body Models (HBMs) for the reconstruction. The biomechanical injury parameters for the accident reconstruction were plotted and compared with injury thresholds for concussion. The kinematic results achieved from the drop test simulations showed a considerable decrease in peak values for resultant accelerations, resultant rotational accelerations, and resultant rotational velocities. These results also exhibited better CORrelation and Analysis (CORA) scores than previously achieved. The biomechanical analysis of the accident reconstruction showed the strains in the brain for the concussed player to be more than the threshold for concussion, which confirms the validity of the reconstruction approach. The results of this study show an improved response of the helmet FE model under different impact conditions. They also present a methodology for ice hockey accident reconstruction using two full body HBMs.
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Lohse, Nils [Verfasser], Henning [Akademischer Betreuer] Schliephake, Nikolaus [Akademischer Betreuer] Gerstdorff, and Thomas [Akademischer Betreuer] Crozier. "Tissue Engineering von Knochen-Vergleichende Untersuchung der Differenzierung humaner Knochenmarkstromazellen (hBMSC) auf Kalziumkarbonat-Biomaterialien unter Verwendung zweier unterschiedlicher Besiedelungstechniken / Nils Lohse. Gutachter: Henning Schliephake ; Nikolaus Gerstdorff ; Thomas Crozier. Betreuer: Henning Schliephake." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042733147/34.

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ASTROLOGO, LETIZIA. "La Displasia Fibrosa in modelli in vitro e in vivo." Doctoral thesis, 2014. http://hdl.handle.net/11573/917778.

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La displasia fibrosa (DF) è una malattia genetica dell’osso e del midollo osseo causata da mutazioni missenso attivanti nel gene codificante per la subunità α della proteina G stimolatoria, Gs (Gsα). Fratture patologiche, deformità e dolori ossei rappresentano comunemente l’espressione clinica della malattia, correlata a sostituzione di osso normale e midollo osseo con tessuto abnorme, a carente mineralizzazione ed instabilità dell’osso, a midollo osseo fibrotico e non ematopoietico. Tali anomalie dipendono dalla disfunzione delle cellule che formano l’osso (osteoblasti), causata dalla presenza della mutazione nelle cellule stesse e nei loro progenitori, le cellule stromali del midollo osseo (BMSC). Ad oggi, non sono note le modificazioni molecolari generate dalla mutazione, né quale sia il contributo dei diversi tipi cellulari al fenotipo malattia, né è disponibile una cura efficace per la DF. Per definire esaustivamente a livello molecolare, cellulare ed organismico gli eventi fisiopatologici della DF, e per identificare nuove strategie terapeutiche, abbiamo generato e studiato modelli di DF in vitro e in vivo. Per analizzare la modulazione trascrizionale indotta dalla mutazione attivante di Gsα (R201C), abbiamo esaminato con i microarray il profilo di espressione di BMSC umane, ingegnerizzate per esprimere stabilmente la mutazione GsαR201C. L’analisi interpretativa dei dati di microarray ha evidenziato la modulazione di geni che sottendono i fondamentali cambiamenti tissutali osservati nella DF, tra cui MGP (artefice della sotto-mineralizzazione dell’osso) e RANKL (responsabile dell’eccessivo riassorbimento osseo), entrambi possibili bersagli terapeutici. D’altra parte, per valutare il contributo di specifiche popolazioni cellulari al fenotipo malattia abbiamo generato modelli murini che consentono l’espressione tessuto-specifica di GsαR201C. In particolare, abbiamo prodotto topi con l’espressione della GsαR201C confinata alle cellule murali, ossia i progenitori scheletrici intesi come cellule microvascolari. L’analisi ai raggi X di questi animali ha messo in luce un’alterazione radiografica delle ossa femorali dei topi, suggerendo che l’espressione della Gsα mutata nelle cellule murali causi anormalità del tessuto scheletrico. Inoltre, per ottenere nuovi modelli murini tessuto-specifici, abbiamo prodotto topi condizionali per l’espressione tessuto-specifica della GsαR201C (Lox-Stop-Lox-GsαR201C). Lo studio radiografico di questi animali ha confermato l’assenza di anomalie ossee. Questi animali potranno essere incrociati con topi che esprimano la ricombinasi Cre nei diversi tessuti di interesse, per ottenere un’ ampia gamma di topi GsαR201C tessuto-specifici. Nel suo insieme, questo lavoro è stato importante per l’identificazione di possibili bersagli terapeutici, ha contribuito a definire l’istopatogenesi molecolare della DF, e, in particolare, dall’uso/analisi di topi GsαR201C tessuto-specifici, potrà derivare un’ulteriore caratterizzazione della patologia.
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"The Development of Biomimetic Biomaterials to Present Microenvironmental Cues for the Regulation of hBMSC Differentiations." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292701.

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Lohse, Nils. "Tissue Engineering von Knochen-Vergleichende Untersuchung der Differenzierung humaner Knochenmarkstromazellen (hBMSC) auf Kalziumkarbonat-Biomaterialien unter Verwendung zweier unterschiedlicher Besiedelungstechniken." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B26B-8.

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Drescher, Maren [Verfasser]. "Der Einfluss von zyklischem mechanischem Dehnungsstress und Dexamethason auf die osteogene Differenzierung von humanen stromalen Zellen aus dem Knochenmark (hBMSC) / vorgelegt von Maren Drescher." 2008. http://d-nb.info/988455439/34.

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Hildebrandt, Kristin [Verfasser]. "Implantation von Tricalciumphosphat (TCP) und humanen Knochenmarkstammzellen (hBMSC) mit exogenem und endogenem rekombinanten Bone-morphogenetic-Protein-2 (BMP-2) in ein Femur-Defektmodell der Ratte zur Beschleunigung der interkonnektiven Knochenheilung / vorgelegt von Kristin Hildebrandt." 2004. http://d-nb.info/973950218/34.

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Book chapters on the topic "HBMS4"

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Bellare, Mihir, and Wei Dai. "Chain Reductions for Multi-signatures and the HBMS Scheme." In Lecture Notes in Computer Science, 650–78. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-92068-5_22.

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Awofeso, Niyi. "Smart Approaches for Optimizing Learning and Assessments in Online University Courses." In Enhancing Higher Education Accessibility Through Open Education and Prior Learning, 93–115. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-7571-0.ch005.

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This chapter discusses findings from two initiatives for optimizing the quality of learning and assessments in online university courses at Hamdan Bin Mohammed Smart University: (1) use of mandatory assessment policy of self-paced classes to promote learner engagement and (2) achievement of learning outcomes and fairness of assessments using question and answer discussion forum platform compared with the more commonly used general discussion forum platform. With regards to the first initiative, the author undertook a case study of a policy of mandating assessment of engagement with self-paced classes at HBMSU between 2016 and 2017. Also, the author discusses findings from operational research to address the following questions: (1) How appropriate is the Q&A variant of online discussion forums in facilitating both cooperative and collaborative learning? (2) How may course facilitators equitably grade online learning individual and collaborative learning activities using Q&A discussion forums?
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Awofeso, Niyi. "Utilizing Question and Answer Discussion Forums to Enhance Learning in University Health Courses." In Advances in Educational Technologies and Instructional Design, 235–51. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5255-0.ch014.

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This chapter examines the contributions of Moodle's Q&A discussion forum platforms to optimizing cooperative and collaborative learning, validity of assessment of discussion forum posts, and achievement of course outcomes. The author studied: (1) How appropriate is the Q&A variant of online discussion forums in facilitating individual and collaborative learning? (2) How may course facilitators equitably grade online learning individual and collaborative learning activities using Q&A discussion forums? (3) Do learners' performance in Q&A category of online discussion forums predict performance in other assignments in online courses? (4) How well do learning activities in Q&A forums achieve courses' learning outcomes compared with other learning approaches? Survey and data analysis conducted by the author at HBMSU, UAE revealed that Moodle's Q&A discussion forum compares favorably with other teaching approaches in facilitating cooperative and collaborative learning, predicting overall learning achievement as well as improving validity of assessments.
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Conference papers on the topic "HBMS4"

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Weaver, Caitlin M., Anna N. Miller, and Joel D. Stitzel. "Pelvic Injury Survival Analysis for a Finite Element Human Body Model Using Multiple Data Sets." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-88447.

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Finite element (FE) computational human body models (HBMs) have gained popularity over the past several decades as human surrogates for use in blunt injury research. FE HBMs are critical for the analysis of local injury mechanisms. These metrics are challenging to measure experimentally and demonstrate an important advantage of HBMs. The objective of this study is to evaluate the injury risk predictive power of localized metrics to predict the risk of pelvic fracture in a FE HBM. The Global Human Body Models Consortium (GHBMC) 50th percentile detailed male model (v4.3) was used for this study. Cross-sectional and cortical bone surface instrumentation was implemented in the GHBMC pelvis. Lateral impact FE simulations were performed using input data from tests performed on post mortem human subjects (PMHS). Predictive power of the FE force and strain outputs on localized fracture risk was evaluated using the receiver operator characteristic (ROC) curve analysis. The ROC curve analysis showed moderate predictive power for the superior pubic ramus and sacrum. Additionally, cross-sectional force was compared to a range of percentile outputs of maximum principal, minimum principal, and effective cortical element strains. From this analysis it was determined that cross-sectional force was the best predictor of localized pelvic fracture.
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Cevik, Ziysan Buse, Aylin Korkmaz, and Ozan Karaman. "Effects Of Laminin Derived Peptides On HBMSC-HUVEC Coculture." In 2021 Medical Technologies Congress (TIPTEKNO). IEEE, 2021. http://dx.doi.org/10.1109/tiptekno53239.2021.9632931.

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Chang, Richard, Namrata Thakur, Jie Wang, Yurni Li, Ser Choong Chong, and Ramanpreet Singh Pahwa. "Efficient and Adaptive Semantic Segmentation of HBMs using Incremental Learning." In 2023 IEEE 25th Electronics Packaging Technology Conference (EPTC). IEEE, 2023. http://dx.doi.org/10.1109/eptc59621.2023.10457605.

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Pahwa, Ramanpreet Singh, Richard Chang, Wang Jie, Zhao Ziyuan, Cai Lile, Xu Xun, Foo Chuan Sheng, Chong Ser Choong, and Vempati Srinivasa Rao. "3D Defect Detection and Metrology of HBMs using Semi-Supervised Deep Learning." In 2023 IEEE 73rd Electronic Components and Technology Conference (ECTC). IEEE, 2023. http://dx.doi.org/10.1109/ectc51909.2023.00161.

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Jie, Wang, Richard Chang, Xu Xun, Cai Lile, Chuang Sheng Foo, and Ramanpreet Singh Pahwa. "Improved Bump Detection and Defect Identification for HBMs using Refined Machine Learning Approach." In 2022 IEEE 24th Electronics Packaging Technology Conference (EPTC). IEEE, 2022. http://dx.doi.org/10.1109/eptc56328.2022.10013164.

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Pahwa, Ramanpreet Singh, Richard Chang, Wang Jie, Xu Xun, Oo Zaw Min, Foo Chuan Sheng, Chong Ser Choong, and Vempati Srinivasa Rao. "Automated Detection and Segmentation of HBMs in 3D X-ray Images using Semi-Supervised Deep Learning." In 2022 IEEE 72nd Electronic Components and Technology Conference (ECTC). IEEE, 2022. http://dx.doi.org/10.1109/ectc51906.2022.00297.

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Ahsanuzzaman, Mohammad, Mohammed A. Gabr, and Roy H. Borden. "An Approach to Predict Unknown Diameter of Hollow-Bar Micropiles (HBMs) in Sandy Soils Considering Installation Parameters." In Geo-Congress 2020. Reston, VA: American Society of Civil Engineers, 2020. http://dx.doi.org/10.1061/9780784482780.015.

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Rajakumaran, Sriram, Rahul S, Rakesh Mitra Vasireddy, and Suhas Nair. "Developing dynamic driver head envelope for passenger cars considering real-time road conditions." In WCX SAE World Congress Experience. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-01-2493.

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<div class="section abstract"><div class="htmlview paragraph">Ergonomics plays an important role in automobile design to achieve optimal compatibility between occupants and vehicle components. The overall goal is to ensure that the vehicle design accommodates the target customer group, who come in varied sizes, preferences and tastes. Headroom is one such metric that not only influences accommodation rate but also conveys a visual perception on how spacious the vehicle is. An adequate headroom is necessary for a good seating comfort and a relaxed driving experience. Headroom is intensely discussed in magazine tests and one of the key deciding factors in purchasing a car. SAE J1100 defines a set of measurements and standard procedures for motor vehicle dimensions. H61, W27, W35, H35 and W38 are some of the standard dimensions that relate to headroom and head clearances. While developing the vehicle architecture in the early design phase, it is customary to specify targets for various ergonomic attributes and arrive at the above-mentioned dimensions. In general, specifications that relate to headroom are only a consequence of static assessments carried out inside a laboratory and not on real-time driving condition. The static assessment can be as simple as positioning a digital manikin in CAD environment and then specifying how high or low the interior trim of the headliner be to achieve a certain head clearance. In actual driving scenario, the vehicle would experience rough terrain. In such cases, the road undulations can displace the occupant from their normal seated position in effect reducing the head clearance. Therefore, it is important to understand this dynamic variance of head clearance on actual driving condition. Undertaking a volunteer test to study this variance comes with risk of endangering the participant and has other measurement related complexities. Hence, we adopt a simulation-based approach for the same using Human Body Models (HBMs) of different anthropometry, which are proven having high bio-fidelity. The aim of this study is to validate this hypothesis and develop a head envelope for drivers considering dynamic road conditions, thus enabling vehicle manufactures digitally evaluate head clearance during early development phase. A typical driving scenario with various vehicle speeds on different stochastic roads and braking conditions are simulated using MBS vehicle models and the acceleration signatures from the simulations are used to estimate the vertical lift of driver over the seat. The resulting displaced posture is compared with the normal driving posture and various head clearances are analyzed. The outcome of this work will help in validating and (or) updating the static head envelope and use it for specifying the headroom target for driver in the early phase of the vehicle design.</div></div>
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