Dissertations / Theses on the topic 'HAT activity'
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Dunphy, Elizabeth Louise. "TAF1 HAT activity in cell proliferation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6250.
Full textHamed, Munerah. "Effect of p300 HAT Activity on Myogenic Differentiation." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23707.
Full textBrooks, Kimberlee. "Grade nine students and policy : perspectives of the school nutrition and physical activity environment." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Health Sciences, c2012, 2012. http://hdl.handle.net/10133/3114.
Full textxi, 179 leaves : ill. ; 29 cm
Husain, Ralf. "Hat die Belastung gestillter Kinder mit persistenten organischen Schadstoffen Einfluss auf natürliche Killerzellen?" Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15045.
Full textBreast-fed infants are exposed to persistent organic pollutants (POPs) via breast milk. Animal studies indicate a special sensitivity of the maturing immune system to POPs. Possible effects of these compounds on the infantile organism are so far barely examined. Potential influences of several POPs (PCDDs, PCDFs, PCBs, beta-HCH, HCB and pp-DDE) on natural killer (NK) cells and NK activity of breast-fed infants in comparison to formula-fed infants were investigated. NK cells are a subset of lymphocytes (CD3-CD56/16+) that can kill allogeneic, virus-infected and malignant cells via their cytotoxic activity without prior sensitization. The study group consisted of 66 healthy infants examined at age 11 to 12 months, of which 50 infants were breast-fed and 16 infants were formula-fed. 13 breast-fed infants came from a region with known increased PCDD/PCDF-burden. Numbers of NK cells were measured by flow cytometric immunophenotyping. NK activity was analysed by a non-radioactive flow cytometric cytotoxicity assay. POP concentrations in the blood fat of the probands were calculated commercially. There were no significant differences between breast-fed and formula-fed infants concerning number and activity of NK cells in the t-test. Analysis of correlation showed no significant influences of POP concentrations on the number and activity of NK cells. In the course of the study the data obtained by the employed cytotoxicity assay proved to be only semiquantitative. The presented findings and further results concerning the immune system of the study subjects suggest that the relatively high burden of long-term breast-fed infants with POPs does not lead to a biological effect in the infantile organism. Regarding the proven positive effects of breast-feeding the existing recommendation to breastfeed can be encouraged.
Worku, Netsanet, August Stich, Arwid Daugschies, Iris Wenzel, Randy Kurz, Rene Thieme, Susanne Kurz, and Gerd Birkenmeier. "Ethyl pyruvate emerges as a safe and fast acting agent against Trypanosoma brucei by targeting pyruvate kinase activity." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-179599.
Full textHart, Jonathan Michael. "The influence of biofilm on the antifungal activity of amine oxide." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-015-Hart-index.htm.
Full textTitle from title page screen (viewed on August 11, 2009). Research advisor: Jegdish P. Babu, Ph.D. Document formatted into pages (ix, 32 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 28-31).
Olsson, Kristina, and Helena Bäckström. "Tjugoåringars upplevelse av vilka faktorer som har haft betydelse för hur fysiskt aktiva de varit över tid." Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-31502.
Full textABSTRACT Background: Physical activity promotes health, and will have positive effects for the body. Children and adolescents physical activity is influenced by different factors at individual and environmental level. The factors integrate with each other and affect the physical activity in different ways and can be divided into different systems according to the ecological systems theory. It could for example involve the attitudes of parents and friends and how the physical environment is designed. Aim: Based on Ecological systems theory the purpose of this study is to examine 20-yearolds experience of which factors that have had an impact on their physical activity from 11 years old until today. Method: The study was conducted with a qualitative design with inductive approach. Five participants were interviewed based on an interview guide containing semi-structured questions. Qualitative content analysis was used to analyze and interpret the material. Result: The analysis resulted in 4 categories with 14 subcategories. The categories were: "Involvement in sport is affected by internal feelings and external demands", "Being a part of the community", "The impact of physical environment and socioeconomic conditions" and "Other possible factors affecting the activity". Conclusion: The result showed that the factors with the greatest impact is within the micro and exosystems. The factors varies over time and focuses on parents, friends and availability.
Lloyd, Jonathan Andrew. "Hate Managers and Where They Target: An Analysis of Hate Crime as Hate Group Self-Help." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/90883.
Full textMaster of Science
In my thesis, I ask the question of how hate groups methodically encourage where hate crimes occur. I do this by creating the concept of the hate manager. Hate managers are figures which influence would-be criminals into their illegal acts. They do this by stoking the fears necessary for them to act outside legal boundaries in reaction to some feeling of threat, an act known as self-help. Hate crimes, I argue, are a form of self-help where the feeling of threat is directed towards individuals belonging to some marginalized group. By looking at data collected by various agencies in the state of Virginia, I discover that the presence of a hate group in a county is a stronger predictor for such acts than any other factor for hate crime likelihood. By doing so, I demonstrate that hate crimes are a form of social control. That is, I argue that hate groups maintain a sense of order or ranking by means of illegal and disciplinary self-help in the form of hate crimes. I conclude my thesis by outlining suggestions for future exploration of the hate manager’s role.
Aymard, Chloé. "Nouvelles méthodes électrochimiques pour le criblage d’inhibiteurs de transcétolases." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1212/document.
Full textThis thesis focuses on the development of a new electrochemical method allowing the high throughputscreening of enzyme inhibitors. For this purpose, a target enzyme has been selected for its therapeutic interest,transketolase (TK): this enzyme is involved in many diseases (cancer, neurodegenerative diseases, diabetes ...) and inthe survival of pathogenic parasites. To measure TK activity, two reporter systems have been developed by usingelectrochemical plates, composed of 96 independent electrodes.The first one is based on a bienzymatic system, requiring the use of an auxiliary enzyme, galactose oxidase(GAOx), in its soluble form or immobilized in laponite. This enzyme is able to oxidize TK products and producehydrogen peroxide. The 96-well format allowed to quickly optimize the electrochemical detection of oxidase activityby intermittent pulse amperometry (IPA) of oxidase activity and only 10 minutes are required to perform 96simultaneous measurements. In parallel, in order to harness the 96-well electrochemical system, this detection ofoxidase activity was also carried out in 10 minutes using electrochemiluminescence. This method is more sensitiveand less variable than IPA but is limited to the use of soluble enzymes. However, the reaction conditions are notoptimal for the bienzymatic system (TK-GAOx): long incubation times are required and are poorly adapted for thescreening of TK inhibitors.A second reporter system no longer requiring an auxiliary enzyme and involving only one TK substrate hasbeen optimized. This system relies on the oxidation by ferricyanide of the reactional intermediate resulted of thebinding of the cofactor (thiamine pyrophosphate) and the substrate. This method allows to measure 96 TK activitiesin only 7 minutes and was easily used to screen an in-house chemical library. The screening of 1360 molecules leadto the identification of a new TK inhibitor with an IC50 of 63 μM. This electrochemical system was also used todetermine the mechanism of inhibition (partial non-competitive mechanism) and the associated inhibition constant(3.4 μM). These results are innovative in the field of electrochemistry and offer a wide range of applications forenzymatic activity screening or the screening of enzymes inhibitors
Hall, Lori L. "Race and Online Hate: Exploring the Relationship between Race and the Likelihood of Exposure to Hate Material Online." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82037.
Full textPh. D.
Haq, Rizwan ul [Verfasser]. "Modulation of hippocampal sharp wave-ripple activity in vitro / Rizwan ul Haq." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/102669471X/34.
Full textMcKelvie, Mary. "Surveilling Hate/Obscuring Racism?: Hate Group Surveillance and the Southern Poverty Law Center's "Hate Map"." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/7060.
Full textNusair, Arwa Y. "Comparison of Aspartate Transcarbamoylase Activity Between Pseudomonas Aeruginosa Which Has One Chromosome and Burkholderia Cepacia Which Has Three Chromosomes." Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc149646/.
Full textEnebrink, Maria. "Föräldrars upplevelser av att leva med ett barn som har astma : En kvalitativ studie." Thesis, Högskolan i Gävle, Akademin för hälsa och arbetsliv, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-12128.
Full textSikk, Helis. "Affective Economies of Activism: Reimagining Anti-Lgbtq Hate Crime." W&M ScholarWorks, 2016. https://scholarworks.wm.edu/etd/1477068228.
Full textPasupuleti, Vinay. "A novel peptide derived from the functional domain of AGGF1 has anti-angiogenic activity." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310957711.
Full textWatanabe, Koji. "Pterin-6-aldehyde, an Inhibitor of Xanthine Oxidase, Has Superoxide Anion Radical Scavenging Activity." Kyoto University, 2000. http://hdl.handle.net/2433/151411.
Full textTibell, Håkan. "Vilken påverkan har fysisk aktivitet på lärande." Thesis, Karlstad University, Karlstad University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1012.
Full textABSTRACT
The purpose of the study was to examine, from the point of view of former research findings, what impact physical activity had on learning. I chose to make an explorative/inductive research, to get as much knowledge as possible from the studied presentation of problem, not to limit myself to a specific research theory. The result proved, that school personal and student experienced many positive effects from daily physical activities. The pupils were more pleased. There was more piece and quiet in the classroom. The ability of concentration increased. The social climate was more agreeable, and with this the developement of knowledge was inpacted. Most research scientists also talked about the importance of better self-reliance and good self-understanding as a result of physical activities. It was also mentioned, that the number of violation had decreased and that the results of the national test had improved. The conclusions were, that it was elementary that schoolboards considered, the alterations in Lpo- and Lpf 94 about daily physical activities, seriously. The leaders of the school area had to appropriate resources, that would make it possible for teachers, to make physical activities form an integral part of many subjects. To sum up, learning was impacted positively by physical activities, even if the reported results showed that further research would be needed.
SAMMANFATTNING
Syftet med studien var, att utifrån tidigare forskning, undersöka vilken påverkan fysisk aktivitet hade på lärande. Jag valde att göra en explorativ/induktiv undersökning, för att hämta så mycket kunskap som möjligt från det studerade problemområdet och inte begränsa mig till en specifik undersökningsteori. Resultatet visade, att skolans personal och elever upplevde många positiva effekter av daglig fysisk aktivitet. Eleverna var gladare. Det var lugnare i klassrummet. Koncentrationsförmågan ökade. Det sociala klimatet var behagligare, och med det påverkades kunskapsutvecklingen. De flesta forskare nämnde även betydelsen av ökat självförtroende och god självuppfattning, som resultat av fysisk aktivitet. Det framkom också, att antalet kränkningar hade minskat och att resultaten på de nationella proven hade blivit bättre. Slutsatser blev, att det var primärt att skolledning tog förändringarna, i Lpo och Lpf 94, om daglig fysisk aktivitet på allvar. Ledarna i skolans värld borde avsätta mer resurser, som möjliggör för lärare att ämnesintegrera fysisk aktivitet. Sammanfattningsvis, påverkades lärande positivt av fysisk aktivitet, även om resultaten som redovisades visade, att det krävdes ytterliggare forskning.
Hoeger, Ivonne. "Men hate it, women love it? : a critical examination of shopping as a gendered activity." Thesis, University of Exeter, 2009. http://hdl.handle.net/10036/92361.
Full textOlsson, Malin. "Det som utförs med kroppen påverkar knoppen? : En litteraturstudie om vilken inverkan fysisk aktivitet har på barns lärande och skolprestationer." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-19791.
Full textLaurent, Fabien. "Impact de l'oxydation chimique et de la refonctionnalisation sur des paramètres physico-chimiques et biologiques de terres contaminées au HAP." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0033/document.
Full textIn order to clean up polycyclic aromatic hydrocarbon (PAH) contaminated soils, various techniques have been developed during the last decades, but their impact on soil functions was rarely considered. The objective of this study was to assess the impact of chemical oxidation treatments on different physico-chemical and biological parameters of PAH contaminated soil and to propose solutions to improve the biological functioning of oxidized soil. Various laboratory and field experiments have shown that the efficiency of chemical oxidation reactions (Fenton reaction and activated persulfate) on PAH concentrations depended on pollutant availability and soil physico-chemical properties. Besides, intense acidification processes have been observed on uncarbonated soil with a strong impact on soil physico-chemical and biological parameters. Moreover, this alteration was higher with activated persulfate treatment, leading to the loss of trace metals in water percolation. In the strongly acidified soil, the input of materials, suitable for pH increase, resulted in the restoration of biological activities and soil capacity to support vegetation. The association of chemical oxidation treatment and restoration techniques could present a good mean for soil rehabilitation. Finally, an index, which aimed to represent soil conditions based on the weight given to different parameters, was proposed and was used to evaluate changes induced by oxidation treatments and restoration techniques
Wright, Colin W., Peter A. Linley, R. Brun, S. Wittlin, and E. Hsu. "Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity." MDPI Publishing, 2010. http://hdl.handle.net/10454/4539.
Full textAncient Chinese herbal texts as far back as the 4th Century Zhou hou bei ji fang describe methods for the use of Qing Hao (Artemisia annua) for the treatment of intermittent fevers. Today, the A. annua constituent artemisinin is an important antimalarial drug and the herb itself is being grown and used locally for malaria treatment although this practice is controversial. Here we show that the ancient Chinese methods that involved either soaking, (followed by wringing) or pounding, (followed by squeezing) the fresh herb are more effective in producing artemisinin-rich extracts than the usual current method of preparing herbal teas from the dried herb. The concentrations of artemisinin in the extracts was up to 20-fold higher than that in a herbal tea prepared from the dried herb, but the amount of total artemisinin extracted by the Chinese methods was much less than that removed in the herbal tea. While both extracts exhibited potent in vitro activities against Plasmodium falciparum, only the pounded juice contained sufficient artemisinin to suppress parasitaemia in P. berghei infected mice. The implications of these results are discussed in the context of malaria treatment using A. annua infusions.
Hugoni, Mylène. "Structure et activité des Archaea planctoniques dans les écosystèmes aquatiques." Thesis, Clermont-Ferrand 2, 2013. http://www.theses.fr/2013CLF22388/document.
Full textAquatic Archaea are important players among microbial plankton and significantly contribute to biogeochemical cycles, especially nitrogen, but details regarding their community structure and seasonal activity and dynamics remain largely unexplored. In marine ecosystems, the widespread distribution of Ammonia Oxidizing Archaea (AOA) suggests that they probably play a major role in nutrients cycling. However, we cannot generalize these observations to all aquatic ecosystems because of their high diversity and/or a lack of information and studies on these organisms for some of these ecosystems. More precisely, lacustrine and coastal ecosystems were less studied while they are potentially subjected to strong anthropogenic impacts. Moreover, notable differences in terms of diversity and activity between marine and freshwater communities can be expected, considering the specific environmental parameters of each ecosystem. The objectives of this thesis were: i) to study the archaeal community structure across a temporal scale and assess the diversity of archaeal communities and AOA in diverse aquatic ecosystems along anthropogenic and/or salinity gradient (lacustrine, estuarine and coastal ecosystems); ii) to determine their relative contribution in ammonia oxidation, compared to Ammonia Oxidizing Bacteria (AOB) by looking at their spatial and temporal distribution and activity, and iii) to explore more precisely the environmental parameters that could drive AOA and/or AOB establishment
Bennett, Cheryl Louise. "Investigating Hate Crimes in Farmington, New Mexico." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293748.
Full textAndersson, Ellinor. "Har ett idrottsmedlemskap som barn någon betydelse för den fysiska aktiviteten som vuxen?" Thesis, University of Gävle, Faculty of Health and Occupational Studies, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7122.
Full textSyftet med studien var att undersöka om studenter tror att deras fysiska aktivitetsnivå idag påverkats av ett medlemskap i en idrottsförening som barn, samt ta reda på deras egen upplevda aktivitetsnivå idag. Det är en kvalitativ deskriptiv undersökning och därför var intervjuer den mest lämpliga metoden att använda. Individuella intervjuer gjordes med tretton studenter på en högskola. Det framkom i resultatet att deltagarna hade inställningen att den fysiska aktivitetsnivån som äldre, kunde ha påverkats av ett medlemskap i en idrottsförening som barn och unga. Detta troddes bero på bland annat den positiva känsla som idrottande gav och som gjorde att fysisk aktivitet upplevdes som något bra och roligt. Även andra saker spelade in som sammanhållningen som fanns vid idrottande. Detta var i sin tur en orsak till att en positiv känslan för fysisk aktivitet infann sig. Det gick även att urskilja ett mönster mellan tidigare idrotter och hur deltagarna motionerade idag. De som till exempel spelat fotboll som yngre, använde det som en motionsform även idag, detta skedde både på eget organiserade träffar med vänner men också som träffar som var organiserade av utomstående.
The purpose of this study was to examine whether students' memberships in sports clubs has affected their attitudes towards physical activity and physical activity level. It was a qualitative descriptive survey based on individual interviews. Results showed that there was a pattern between the former sports membership and current patterns of physical activity. For instance, those who liked playing football at a young age, continue to adopt the same type of exercise today. This pattern applies to other types of physical activity, with or without club membership. In addition, many respondents thought that a club membership at a young age could have an impact on their physical activity as adults. This was mainly due to the positive feeling that sportsmen perception, that physical activity was something good and fun. Social cohesion in sport was the one thing that many of those interviewed believed was a major reason why sports, was perceived as positive.
Hansson, Sandra, Josefine Landén, and Emma Orrefalk. ""Vi har nog en väg att vandra" : Medarbetares upplevelser av en aktivitetsbaserad arbetsplats." Thesis, Högskolan i Borås, Akademin för vård, arbetsliv och välfärd, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-648.
Full textToday’s changeable society requires a great deal of organizations adaptability which in turn puts high demands on the office design to meet this changeability. An office concept that is attaining more attention from Swedish organizations is the activity-based concept. At an activity-based workplace, which is made up by different activity-areas, the employee can choose a workstation that best supports the activity at hand. Some of the uttered pros of activity-based workplaces are the decrease in use of office space as well as the increase in communication and productivity. The purpose of this research is to receive an understanding for the employee’s experience of the activity-based workplace, in a public organization. We will furthermore view if the intentions with the implementation, of the office concept, are shown in the employees’ experiences. The research was carried out at Kungälvs stadshus who just recently started working activity-based. Interviews and observations, with a qualitative approach, were carried out. The major findings of this research was that the respondents experiences of the workplace, in most cases, weren’t connected to the activity-based concept as such. Instead it was connected to the physical environment. The majority of the respondents experienced that the workplace supported them in their work. However, the experiences differed some, due to the employee’s assignment. Another finding was that the employees didn’t use all the resources in the workplace and was restricted in their mobility. Further the research shows that some of the intentions, with the implementation of the office concept, are shown in the employees’ experiences and some of the intentions are not shown. The value of this research lies in the fact that the research in this area is limited and the research that exists is done with a quantitative approach. Furthermore, the research illuminates the, all too rarely researched employee-perspective.
Kock, Elina, and Yamma Sarwari. "How can machine learning help identify cheating behaviours in physical activity-based mobile applications?" Thesis, Malmö universitet, Fakulteten för teknik och samhälle (TS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20791.
Full textThis study investigates the possibility to use machine learning for Human Activity Recognition (HAR) in Bamblup, a physical activity-based game for smartphones, in order to detect whether a player is cheating or is indeed performing the required activity. Sensor data from an accelerometer and a gyroscope from an iPhone 7 was used to gather data from various people performing a set of activities. The activities of interest are jumping, squatting, stomping, and their cheating counterparts, fake jumping, fake squatting, and fake stomping. A Sequential model was created using the free open-source library TensorFlow. Feature Selection was performed using the program WEKA (Waikato Environment for Knowledge Analysis), to select the attributes which provided the most information gain. These attributes were subsequently used to train the model in TensorFlow, which gave a classification accuracy of 66%. The fake activities were classified relatively well, and so was the stomping activity. Jumping and squatting had the lowest accuracy of 21.43% and 28.57% respectively. Additionally, the Random Forest classifier in WEKA was tested on the dataset using 10-fold cross validation, providing a classification accuracy of 90.47%. Our findings imply that machine learning is a strong candidate for aiding in the detection of cheating behaviours in mobile physical activity-based games.
Ljungberg, Angelica. "Fysisk aktivitet och hälsosam kost : Vad har grundskoleelever fått med sig för kunskaper från skolan?" Thesis, Karlstads universitet, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-28585.
Full textMalm, Moa. "Har fysisk aktivitet och sömn påverkan på arbetsminnet hos äldre individer? : En kvantitativ studie." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79812.
Full textThis study has examined the sleep of older individuals as well as physical activity in relation to working memory. The aim of the study was to investigate whether a relationship exists between them. The research questions were whether physical activity affects the working memory of older people and whether sleep is a contributing factor to better working memory. Data set for the study consisted of a total of 181 individuals who were between 50-75 years old. The method used in the study was a quantitative questionnaire and three different tests of the participants working memory. Statistical analysis of data collected was carried out using the SPSS program. Results showed a significant relationship between the participants age and working memory. Level of education was also something that affected the results of the working memory tests for the participants. Unfortunately, it could be concluded that sleep was not positively related to working memory. Another conclusion was that physical activity and age had a correlation but no causal relationship to participants working memory performance that could be explained.
Saidi, Oussama. "Sommeil de l'adolescent : effet de l'activité physique et de l'alimentation chez l'adolescent sportif ou en condition d'obésité." Thesis, Université Clermont Auvergne (2017-2020), 2020. http://www.theses.fr/2020CLFAC059.
Full textPhysical activity and ingested nutrients take part in the regulation of the internal clock andsleep physiology. Recently, there has been a surge of interest in this topic. However, studiesremain almost exclusively limited to adults. Adolescence is marked by critical transitionsthat may trigger several behavioral disturbances particularly with regard to sleep. A problemcompounded by an array of endogenous and exogenous factors forming the so called“Perfect Storm” of both altered sleep duration and quality. Obesity and elite sport are twofactors that have been separately associated with sleep disturbances, and have a negativeimpact on holistic development, with lowered performance and altered health status ofadolescents, both physical (recovery, metabolism, growth, weight control) and cognitive(learning, memory, decision-making, vigilance). Therefore, the purpose of this work was toexplore the effect of physical activity and nutrition on sleep among these two distinctadolescent populations. Altered sleep pattern in young athletes seems to be more related tosport constraints such as competition and travel. However, acute exercise improves sleepduration in quality in both populations (athlete and with obesity). Moreover, dietary intakeseems to be a promising alternative to improve sleep quality. Only three days undercontrolled feeding fixed at the recommended dietary allowance resulted in reduced sleeponset latency in adolescents with obesity compared to ad-libitum condition. Finally,randomized controlled studies are needed to support the effect of certain nutrients on sleep.PROTMORPHEUS study will bring a fuller understanding of the effect of proteintryptophan/large neutral amino acids ratio on sleep
Lieber, Diana. "Functional assays for screening antibody activity in droplet-based microfluidics." Strasbourg, 2010. https://publication-theses.unistra.fr/public/theses_doctorat/2010/LIEBER_Diana_2010.pdf.
Full textHigh-throughput, cell-based assays require small sample volumes to reduce assay costs and to allow for rapid sample manipulation. However, further miniaturisation of conventional microtiter plate technology is problematic due to evaporation and capillary action. To overcome these limitations, we developed droplet-based microfluidic platforms in which cells are grown in aqueous microcompartments separated by an inert perfluorocarbon carrier oil. Furthermore, this system allowed for an automated analysis of individual compartments subsequent to an incubation period as required for high-throughput, cell-based assays. In addition, we focused on the development of functional assays for screening antibody activity, e. G. Neutralisation of HIV or the inhibition of ACE-1. Common high throughput approaches for antibody screening use phage display or hybridoma cells. Phage display is powerful but based on binding properties rather than neutralising effects. Hybridoma cells allow for direct screening of neutralising activity, but are very restricted in the number of clones that can be screened due to their generation and proliferation as required for conventional screens. The aim of this study was the development of novel screening technology with the ultimate goal of screening single antibody-releasing cells (hybridoma cells). This system should also allow for direct B-cell screening. Once established, this technology could be used for the screening/ selection of many more therapeutic antibodies
Elfving, Elias. "Analysis on how to estimate the number of holes a drill rig has completed based on its activity." Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-85474.
Full textMäki, Sami. "Har rock en roll för hälsan? : En fokusgruppsstudie på hur musicerande i grupp inverkar på vuxna deltagarnas välbefinnande och empowerment." Thesis, Högskolan i Gävle, Avdelningen för arbets- och folkhälsovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-14409.
Full textSyftet med denna kvalitativa studie var att bidra till förståelsen om hur en musikgruppsverk-samhet kan inverka på deltagarnas välbefinnande och empowerment samt att undersöka vad i sammanhanget som kan ge upphov till denna inverkan.Missivbrev skickades till 13 vuxna deltagare i en rockmusikskola i mellersta Sverige och 7 personer (4 män, 3 kvinnor) deltog sedan i studien. 4 teman diskuterades i fokusgrupper i en strävan att synliggöra hur informanterna berörts av verksamheten samt vilka faktorer som varit betydelsefulla i sammanhanget. Transkriberingen av intervjuerna analyserades sedan genom att meningsbärande enheter plockades ut, kodades och delades upp i teman.Resultaten visade att en rockgruppsverksamhet har inverkan på deltagarnas välbefinnande och empowerment genom ett samlad inverkan av flera faktorer. De teman som framkom i fokus-grupperna med betydelse för denna inverkan är 1) fokus på nuet genom musiken, 2) personlig utveckling, 3) meningsfull fritidssysselsättning samt 4) gruppens egenskaper och under detta tema fanns fyra underliggande teman; delaktighet, likvärdighet, tolerans, samarbete mot ge-mensamt mål och ledarskapet. Studien har lett fram till en ökad förståelse om hur en musik-gruppsverksamhet inverkar på individers välbefinnande och empowerment. Ett avstamp till att synliggöra de medverkande krafterna som har en roll i denna inverkan har påbörjats och det behövs mer forskning med bättre lämpade metoder för att mer ingående belysa fenomenet
Soules, Aurélien. "Apports des activités chimiques et photochimiques des alkyls azides à la synthèse macromoléculaire." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2010. http://www.theses.fr/2010ENCM0001.
Full textThis work aims at using both chemical and photochemical activities of fluorinated telomers bearing azido end groups, to promote the synthesis of thermostable macromolecules and original photocrosslinked networks. In a first part, we have prepared and characterized a novel class of linear poly(alkyl aryl) ethers by the promotion of competitive “Click” reaction and Hay coupling. Then, the photolysis under UV irradiation of these fluorinated polymers was studied and used to generate photocrosslinked materials. The surface free energies of the resulting films were established using the Owens-Wendt model. The roughness and composition of the surfaces were investigated by profilometry, AFM and EDX analysis. Finally, the preparation under UV irradiation of original polymer networks was performed. The post-sulfonation of these materials allowed to prepare new proton exchange membranes for fuel cells application. The microstructures, physical and chemical properties of these electrolytes were investigated
Khozaei, Mahdi. "Increased plastid transketolase activity in transgenic tobacco plants alters carbon metabolism and has negative impacts on growth and yield." Thesis, University of Essex, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522086.
Full textKlaar, Sandra, and Malin Klasson. "Se om din hund har varit en Good Boy med hjälp av glanceable feedback : En designforskning för att implementera glanceable feedback I aktivitetsenheter för hundar." Thesis, Högskolan Kristianstad, Avdelningen för design, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-22076.
Full textThe purpose of this study is to investigate how glanceable feedback can be implemented in activity units for dogs to create a better user experience and reduce the technological disruption in human-dog communication. Previous studies show that the development of activity units for dogs is far from as successful as activity units for humans (Ramokapane, van der Linden & Zamansky, 2019; Väätäjä et al. 2018; Zamansky et al. 2019). Väätäjä, et al. (2018) have pointed out the importance of the technology behind the activity, such as the mobile phone, unit not coming between the dog owner and the dog. It must not act as a disturbance that distances communication or interaction between dog and human (Väätäjä et al. 2018). This is inevitable in today's activity units for dogs as the user is completely dependent on the mobile phone's associated application (Väätäjä et al. 2018). The question (How can glanceable feedback be applied in an activity unit for dogs to give the dog owner direct information on the dog's activity?) Investigates how glanceable feedback can be applied in activity units for dogs and avoid that communication between dog and owner is disturbed by technology. The result is the Good Boy activity unit. The unit is equipped with a display and a mechanical wheel that switches between the different categories distance / step, pulse / body temperature, info /contact information and LED/lamp.
Antero-Jacquemin, Juliana. "Longevity and causes of mortality in elite athletes." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB154/document.
Full textBackground and objectives: along their careers, elite athletes are subjected to specific constraints that distinguish them from the general population. Such constraints, related to the high intensity of their physical activity, their overexposure to injuries or particular lifestyle, may have long-term consequences on the athletes' health, and ultimately on their longevity. Thus, the main goals of the present study are the following: 1) to describe and analyze elite athletes’ longevity and specific causes of mortality in comparison with the general population and according to the type of effort they performed; and 2) to investigate their lifespan trends in comparison with the longest-lived humans in order to apprehend the current scenario of human longevity trends. Methods: we collected data on the biography and the athletic performances of all the French athletes who participated in the Olympic Games (OG) from 1912 to 2012 (n = 4708), and all the French cyclists who participated in the Tour de France (TDF) from 1947 to 2012 (n=786). Then, we verified their vital statuses through the National Registry of Identification of Physical Persons (RNIPP). For the deceased athletes, we obtained the causes of their deaths through the Centre for epidemiology on medical causes of death (CépiDc). We compared the athletes’ overall and specific mortality (according to the main chapters of the International Classification of Disease) with the French civilian life tables using Standardized Mortality Ratio (SMR) and the Kaplan-Meier methods. We adapted and applied the life years-lost method under the competing risk model to quantify differences on longevity due to major causes of death according to the athletes’ type of effort. Furthermore, we collected data on worldwide deceased Olympians participating in the OG from 1896 to 2012 (n=19 012) and on worldwide supercentenarians (>110 years) deceased between 1900 and 2013 (n= 1 205) in order to analyze their lifespan trends using a density analysis tool (total number of life durations per birth date). Findings and conclusion: French elite athletes show consistently lower mortality (≈40-50% lower) in comparison with their compatriots, whether female or male Olympians, or professional cyclists, mostly related with a lower cardiovascular (≈ 40-60% lower) and cancer mortality (≈ 45% lower). No excess mortality was observed in elite athletes for any of the specific causes of death we studied. French Olympians’ lower mortality results in an average of seven years of life saved in relation to the general population. This gain partitioned according to specific causes of deaths shows that cardiovascular longevity benefit is associated with the type of sports practiced during the Olympic career, favoring combined type of effort over very short- or very long-duration effort. In relation to cancer mortality, all types of effort studied were associated with better longevity. Despite their survival advantage, no Olympian in the world, up to date, has ever reached the status of a supercentenarian, as the longest-lived was 106 years old. The common lifespan trends between Olympians and supercentenarians indicate similar mortality pressures over both populations that increase with age, a scenario that is better explained by a biological “barrier” limiting further progression. The supercentenarians’ density trends show a current stagnation of the human longevity
Conchar, Lauren. "Everyone has the right to participate : exploring the lived experiences of adolescents with cerebral palsy and their involvement in physical activity." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86388.
Full textENGLISH ABSTRACT: Engagement in physical activity is a basic human right and has numerous benefits for mental well-being. Persons with disabilities are often denied this right due to a number of barriers existing on physiological, psychological and structural levels. Adolescents with motor impairments may be even further marginalised due to the physical nature of their impairment as well as being at a developmental stage where their opinions may not be taken into account based on their age. Research that has been conducted in this area has mostly focused on the accounts of parents and teachers with little voice being given to adolescents. This research aimed to explore the lived experiences of a group of adolescents with cerebral palsy (CP) and their involvement in physical activity. The sample group consisted of 15 adolescents with CP between the ages of 12 and 18 in the Western Cape. Semi-structured interviews were conducted with the participants. In addition, three staff members were interviewed in order to add a secondary layer of data to the study. The interviews were analysed using interpretative phenomenological analysis which aims to give voice to participants and to make meaning of these accounts through interpretation by the researcher. Five major themes emerged from the data, namely: (1) “When they call me cripple” – what it means to have a motor impairment, (2) My experience of physical activity – perceived benefits, facilitators and barriers to participation, (3) Protective factors and coping strategies employed by participants to overcome barriers to participation, (4) What I would like and what I recommend, and (5) Perceptions of staff members at the school. These themes were discussed through a theoretical framework focused on the psychological and social factors which influence an individual’s participation in (or avoidance of) physical activity. While this theoretical framework is based on able-bodied persons, it was interesting to compare the experiences of adolescents with CP. The findings were further discussed in comparison to the relevant literature, although the purpose of qualitative research is not to necessarily generalise findings. This discussion yielded similarities and differences in terms of experiences relating to barriers and facilitators to participation. In addition, the findings supported the notion that adolescents with disabilities know what they want and have valuable input to offer in terms of their own experiences. Recommendations include further studies being conducted with groups of adolescents with disabilities other than CP as well as in other areas of South Africa. This could give a more rounded understanding of the experiences of adolescents with disabilities and could better inform projects that could be developed.
AFRIKAANSE OPSOMMING: Betrokkenheid in fisiese aktiwiteit is ‘n basiese mensereg en het verskeie voordele vir verstandelike gesondheid. Mense wat gestremdhede het word dikwels ontken van hierdie reg, as gevolg van getalle struikelblokke wat bestaan op fisiologiese, sielkundige en strukturele vlakke. Adolessente met motoriese gestremdhede mag dalk nog meer gemarginaliseerde word as gevolg van die fisiese aard van hul gestremdheid, asook die feit dat hulle in ‘n ontwikkelings stadium is waar hulle opinie dalk nie in ag geneem word nie weens hulle ouderdom. Navorsing wat uitgevoer is in hierdie gebied het meestal gefokus op die mededeling van die ouers en onderwysers en het min stem gegee aan die adolessente self. Hierdie navorsing het daarop gemik om die beleefde ervaringe van ‘n groep adolessente met serebrale verlamming en hulle betrokkenheid in fisiese aktiwiteit te ondersoek. Die monster groep het bestaan uit 15 adolessente met serebrale verlamming tussen die ouderdomme van 12 en 18 in die Wes-Kaap. Semi- gestruktureerde onderhoude was gedoen met die deelnemers. Bykomend is daar ook onderhoude gedoen met drie personeellede om ‘n sekondêre vlak van data aan die studie te verleen. Die onderhoude was geanaliseer deur gebruik te maak van interpreterende fenomenologiese analise, wat daarop gemik is om ‘n stem te gee aan die deelnemers en om sin te maak van hulle beskrywinge deur interpretasie van die navorser. Vyf groot temas het na vore gekom uit die data, naamliks: (1) Wanneer hulle my verlam noem – wat dit beteken om ‘n motorise gestremdheid te hê, (2) My ondervinding van fisiese aktiwiteit – waargenome voordele, fasiliteerders en struikelblokke tot deelname, (3) Beskermende faktore en hanteringsvaardighede wat gebruik word deur die deelnemers om struikelblokke tot deelname te oorkom, (4) Waarvan ek sal hou en wat ek voorstel, en (5) Persepsies van personeellede by die skool. Hierdie temas was bespreek deur ‘n teoreties raamwerk wat gefokus is op die sielkundige en sosiale faktore wat ‘n individu se deelname aan (of vermyding van) fisiese aktiwiteit beïnvloed. Alhoewel hierdie teoretiese raamwerk gebaseer is op ongestremde persone, was dit interessant om die ondervindinge te vergelyk met adolessente met serebrale verlamming. Die bevindinge is verder bespreek in vergelyking met relevante literatuur, al is die doel van kwalitatiewe navorsing nie noodwendig om bevindinge te veralgemeen nie. Die bespreking het ooreenkomste, so wel as verskille ten opsigte van ondervindinge met betrekking tot hindernisse en fasiliteerders tot deelname opgelewer. Daarbenewens verleen die bevindinge ook ondersteuning aan die idee dat adolessente met gestremdhede weet wat hulle wil hê en dat hulle waardevolle insette het om te lewer in terme van hulle eie ervarings. Aanbevelings sluit in dat daar verdere studies gedoen moet word met ‘n groep adolessente wat ‘n gestremdheid anders as serebrale verlamming het, asook om verdere studies te doen in ander areas van Suid-Afrika. Dit sal ‘n meer afgeronde begrip van die ondervindinge van adolessente met gestremdhede lewer en sal ook beter instaat wees om projekte in te lig wat dalk ontwikkel mag word.
Cole, Ashley Kahlil Prentice William E. "The spine and scapula stabilizing S3 brace has an effect on posture and muscle activity in overhead athletes with poor posture." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1864.
Full textTitle from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department Exercise and Sport Science Athletic Training." Discipline: Exercise and Sports Science; Department/School: Exercise and Sport Science.
Garcia, Avalos Tania, and Jose Murillo. "AMONG MASTER OF SOCIAL WORK STUDENTS, WHAT HAS A HIGHER IMPACT ON LEVELS OF STRESS: SPIRITUALITY, PHYSICAL ACTIVITY, OR SELF-COMPASSION." CSUSB ScholarWorks, 2018. https://scholarworks.lib.csusb.edu/etd/672.
Full textAdams, Sarah Jane. "Hell Hath No Fury like a Scorned Soap Fan: A Case Study of Soap Opera Fan Activism." Thesis, North Dakota State University, 2012. https://hdl.handle.net/10365/26500.
Full textKoford, Michelle A. "A Retrospective Study of the Effects of an Incentive Based Fitness and Well Being Intervention Has on Body Fat Loss and Cardiovascular Fitness at a Corporate Work Site." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1408709892.
Full textDool, Carly Jade 1985. "Pharmacologic inhibition of insulin receptor tyrosine kinase activity has antineoplastic effects similar to alloxan-induced insulin deficiency with less acute metabolic toxicity." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111555.
Full textRosenström, Lotta. ""Sån kärlek har man aldrig varit med om..." : En studie av högläsning för personer med demens." Thesis, Stockholms universitet, Institutionen för socialt arbete - Socialhögskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-43502.
Full textVillars, Clément. "Mesure objective de l’activité physique en conditions de vie libre et relations avec l’adiponectine." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10301/document.
Full textAccurate measurements of physical activity in free living are needed to establish what dose of physical activity is necessary for obtaining a specific health benefits. The first aim of this work was to validate the Actiheart (which combines heart rate and accelerometry sensors) with doubly labeled water (DLW). We show a good level of concordance between physical activity energy expenditure (PAEE) estimated by Actiheart and DLW. Individualization of the relationship between heart rate and PAEE by an incremental test is needed for an accurate estimate of the PAEE at the individual level and to evaluate changes induced by an intervention. In laboratory, we show that the accuracy of Actiheart is activitydependent. This requires the establishment of their recognition from new sensors and mathematical models. Adiponectin, hormone secreted by adipose tissue, has a role in energy metabolism and its secretion decreases with obesity. However the effects of physical activity remain in contradiction in published studies. The second objective of this work was to evaluate the effect of physical activity and intervention with weight control on plasma adiponectin. We show that the total and high molecular weight adiponectin were negatively associated with modifications of the physical activity level. Further work is however necessary to understand the mechanisms underlying this modulation of plasma adiponectin which does not seem related to changes in synthesis in adipose tissue or muscle
Fredriksson, Mathias. "Obeskattade reserver : Har en förändring kring användandet och dynamiken mellan periodiseringsfonder och överavskrivningar inträffat?" Thesis, University of Gävle, Department of Business Administration and Economics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-3818.
Full textSyfte: År 2005 infördes en ny lag, att företagen som gjorde avsättningar till periodiseringsfonder var tvungna att beskatta en schablonintäkt som erhölls från de gjorda avsättningarna. Problemet som uppsatsen berör är huruvida användandet av överavskrivningar hade förändrats efter att lagen tillkom för periodiseringsfonder jämfört med tidigare. Dessutom fokuserades det också på vilka konsekvenser obeskattade reserver har fått före och efter att lagen trädde i kraft. Syftet med examensarbetet är att kartlägga hur företagens vanor kring avskrivningar över plan förändrades efter införandet av schablonintäkten på periodiseringsfonder, och om överavskrivningar kan anses som ett substitut till periodiseringsfonder istället för ett komplement.
Metod: En undersökning gjordes på företagen som är listade på börslistan ”large cap”. De åren som undersökningen omfattade var åren 2003, 2004, 2005 och 2006. Företagen som användes var redan förutbestämda, varför urvalet blev ett subjektivt urval. Anledningen till det var för att undersökningen ämnade skapa en stor insikt i Sveriges ledande börsföretags resultatplanering. De data som insamlades hämtades från företagens årsredovisningar, och data sammanställdes i tabeller och diagram.
Resultat & slutsats: Resultatet för undersökningen visade på att företagen hade ett lågt användande av resultatjusteringar redan under år 2003, och det fortsatte att avta allt eftersom åren gick, emellertid fanns en tendens att företagen ökade sitt användande under år 2006.
Periodiseringsfonder var mer vanliga att använda för alla år förutom år 2005. Med detta som underlag blev slutsatsen att överavskrivningar inte är ett substitut till periodiseringsfonder. Vidare tycks företagen inse att det är billigare för dem att inte använda sig av obeskattade reserver, och betala skatten direkt, eftersom färre gjorde avsättningar.
Förslag till fortsattforskning: I uppsatsen koncentrerades urvalet till att enbart omfatta Sveriges 60 största börsnoterade företag, och forskningen bör utvidgas till att omfatta ett mer representativt urval i Sveriges företagsklimat. Anledningen till det är för att kunna erhålla en statistisk säkerställning kring användandet av obeskattade reserver.
Uppsatsens bidrag: Uppsatsen har skapat en större förståelse kring obeskattade reserver och i vilken omfattning de används bland företagens som tenderar att bestämma praxis. Vidare har också djupare kunskap erhållits kring vilken av de två bokslutsdispositionerna som är mest användbar, samt skatters påverkan på företagens valmöjligheter.
Aim: By the year 2005 a new law was introduced, the companies was now being charged with an interest income on the tax allocation reserve. The problem this thesis is based on is how the usage of excess depreciation had changed pre and post the new law was established because this tool do not have a fee for its usage. Additionally this thesis also focused on what consequences this law have had on the general usage of untaxed reserves. The purpose with the thesis is to get an understanding if the usage of excess depreciation changed after the tax allocation reserves was being taxed and if excess depreciation can be a substitute to tax allocation reserve instead of being a complement to it.
Method: A survey was performed, with the companies listed on the Stockholm stock exchange's large cap as the only objects in the survey. The sample of the survey was pre-decided; hence the sample of the survey was subjective, but also because the survey intended to create an insight in the income planning of the leading enterprises of the stock exchange in Stockholm. The years included in the survey were 2003, 2004, 2005 and 2006 and the data, foundation to the survey, was gathered from the companies' annual reports.
Result & Conclusions: The result of the survey showed that the companies had a low usage of appropriations, already back in 2003, which continued to decrease as the years went by however in the year 2006 a tendency was that the companies had increased their usage of untaxed reserves. Tax allocation reserves were more frequently used in all the years except in the year 2005. With regard to this information following conclusions could be made: excess depreciation could not be seen as a substitute to the tax allocation reserve. Moreover, a decrease in the usage of untaxed reserves could also be seen, as the companies realised that it would be cheaper for them not using them.
Suggestions for future research: The survey was narrowed to just include the sixty largest companies traded on the Stockholm exchange; hence the research should be extended to include a more representative sample of all the companies in Sweden. The reason is to find out if the usage in appropriations has changed to the degrees of being statistically significant.
Contribution of the thesis: The thesis has produced a greater understanding about appropriations and to what degree the companies who set praxis are using them. Furthermore, a comprehension about which of the two appropriations that is the most useful has been received, and also how much taxes influence the choices made by companies.
Tanaka, Kuniaki. "Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model." Kyoto University, 2021. http://hdl.handle.net/2433/261609.
Full textGirardot, Charles. "Deciphering enhancer activity in Drosophila based on transcription factor occupancy and chromatin state chromatin state characterization." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00829472.
Full textSkripcevska, Kristina. ""I had to become my own hero" : En utvärderande studie av träningsapplikationen RunKeeper." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-23381.
Full textFysisk aktivitet är en viktig roll för att kunna säkerställa god hälsa och välmående. Motivation är en nyckel faktor för att upprätthålla en hälsosamlivsstil. Tillsammans med dagens moderna teknik har det utvecklats nya innovativa tillvägagångssätt för att motivera människan till regelbunden fysisk aktivitet. Denna studie undersöker hur en träningsapplikation kan bidra till ökad motivation och hur beteendeförändring förekommer vid användning av en träningsapplikation. Kvalitativa datainsamlingsmetoder såsom intervjuer och observationer har använts i denna studie. Resultatet visar att träningsapplikationens förmåga att motivera varierar beroende på användare. Det finns även ett stort intresse att kunna ta del av slutresultat och ha kontroll över den personliga utvecklingen.
Shauli, Mathulo Mathabiso. "Histopathology induced by a medicinal plant indigenous to South Africa that has shown in vitro anti-microbial activity against drug resistant strains of Mycobacterium tuberculosis." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/3990.
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