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1
Gowda, Charitha, Rose Y. Hardy, Steven Traylor, and Gilbert C. Liu. "Trends in healthcare utilisation for firearm-related injuries among a cohort of publicly insured children in Ohio." Journal of Epidemiology and Community Health 75, no. 9 (February 26, 2021): 906–9. http://dx.doi.org/10.1136/jech-2020-215940.
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ObjectiveTo examine healthcare utilisation for all firearm-related injuries among publicly insured children.MethodsA retrospective analysis of firearm injury medical claims among paediatric (<21 years) Medicaid beneficiaries in Ohio from 2010 to 2018. Factors associated with unintentional and intentional firearm injury were explored using multivariable logistic regression. Average annual patient healthcare costs were determined in 2019 US$.ResultsThere were 1061 firearm injury-related claims (853 (80%) unintentional; 154 (15%) intentional; 54 (5%) unknown) occurring in 663 children over 2 736 517 available person-years. From 2010 to 2018, yearly total firearm claims rose from 19.7 to 31.3 per 100 000 persons (p=0.033). Urban children experienced a non-significant increase in firearm claims rate over time (26.1 vs 35.0/100 000; p=0.066) while the claims rate nearly tripled among those in rural areas (8.4 vs 24.0/100 000; p=0.012). Younger age, females and rural residence were associated with reduced odds of injury claims. The average annual costs for emergency department and inpatient visits, respectively, were $260 and $5735.ConclusionRisk and type of firearm injury claims among low-income children in Ohio varies by age, sex and residence. Prevention programmes should be tailored based on these demographics.
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Huehls, Mitchum. "What’s the Matter with Ohio? Liberal Democracy and the Challenge of Irrationality." American Literary History 32, no. 2 (2020): 328–53. http://dx.doi.org/10.1093/alh/ajaa006.
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Abstract This essay mines 100 years of fiction about the irrationalities of small-town Ohio to ask whether liberal democracy can accommodate irrationality or is required, because of its double commitment to equality and liberty, to exclude it. Reading novels from Sherwood Anderson, William Gass, and Stephen Markley, I trace a trajectory from the late nineteenth century of Anderson’s Winesburg, Ohio (1919), when irrationality partially grounded liberal community, to the twenty-first century of Markley’s Ohio (2018), when the irrationalities of violence, addiction, racism, and abuse constitute what I call “piteous solidarity,” a form of solidarity grounded on our shared inhumanity. I conclude by speculating that such piteous solidarity might represent “the mobilization of common affects in defense of equality and social justice” that Chantal Mouffe has recently argued is necessary for constituting the “we” of a left populism.
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Qiu, Xiao, Jane Straker, and Katherine Abbott. "When Is a Nursing Home Complaint Really a Complaint? Making Sense Out of Increased Complaints in U.S. Nursing Homes." Innovation in Aging 5, Supplement_1 (December 1, 2021): 846. http://dx.doi.org/10.1093/geroni/igab046.3095.
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Abstract Official complaints are one tool for addressing nursing home quality concerns in a timely manner. Similar to trends nationwide, the Ohio Department of Health (ODH) has noticed a trend in increasing nursing home complaints and has partnered with the Scripps Gerontology Center to learn more about facilities that receive complaints. Greater understanding may lead to proactive approaches to addressing and preventing issues. This study relies on two years of statewide Ohio nursing home complaint data. Between 2018 and 2019, the average complaint rate per 100 residents went from 6.59 to 7.06, with more than 70% of complaints unsubstantiated. Complaint information from 629 Ohio nursing homes in 2018 was linked with Centers for Medicare and Medicaid Services Nursing Home Compare data, the Ohio Biennial Survey of Long-Term Care Facilities, and Ohio Nursing Home Resident and Family Satisfaction Surveys. Using ordered logistic regression analyses, we investigated nursing home providers' characteristics using different levels of complaints and substantiated complaints. Findings suggest that providers with higher complaint rates are located in urban areas, had administrator and/or director of nursing (DON) turnover in the previous 3 years, experienced decreased occupancy rates, had reduced nurse aide retention, and received lower family satisfaction scores. Additionally, providers with administrator and/or DON turnover, and low family satisfaction scores are more likely to have substantiated complaints. Because increasing numbers of complaints are accompanied by relatively low substantiation rates, policy interventions targeted to specific types of providers may improve the cost-effectiveness of complaint resolution, as well as the quality of care.
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Kennedy, Katherine, Cassandra Hua, and Matt Nelson. "ANALYSIS OF OHIO’S ASSISTED LIVING DIRECT CARE WORKFORCE." Innovation in Aging 7, Supplement_1 (December 1, 2023): 329–30. http://dx.doi.org/10.1093/geroni/igad104.1098.
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Abstract Direct care workers (DCWs) in Ohio’s licensed residential care facilities (RCFs) provide the most assistance with activities of daily living to individuals with disabilities. DCWs include medication aides, personal care aides, and nurse aides. In 2017, 41% of Ohio AL administrators reported high DCW recruitment issues and 36% high DCW retention problems (8+ on 10-point scale). Understanding how RCFs with no or little recruitment/retention challenges compare to other RCFs on strategies used, training hours, wages, benefits, resident composition, and RCF characteristics can identify potential strategies to increase recruitment/retention. This study uses the 2019 Ohio Biennial Survey of Long-Term Care Facilities (n=540 RCFs) to compare RCF strategies to recruit and retain DCWs by measures of recruitment/retention problem-severity and their 3-year retention rates among full-time (FT) and part-time (PT) DCWs. In 2019, 65% of Ohio RCF administrators reported recruitment issues at the median or greater (8+). Similarly, 62% of RCFs experienced retention issues at the median or more (7+). On average, 37% of FT DCWs worked in the RCF for 3 years or more and 21% among PT DCWs (ranges: 0%-100%). 28.24% of RCFs reported high 3-year retention among FT DCWs (60-100%) and 26.51% reported high 3-year retention among their PT DCWs (30%-100%). RCFs with less serious recruitment challenges report providing more hours of training for newly employed DCWs before they provide resident care (34.54 vs. 29.60, t=-2.7, p<.01). Individual retention strategies did not show relationships with high retention. Results indicate pervasive challenges with DCW retention and recruitment that require new approaches.
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Calder, Dale R. "Charles Wesley Hargitt (1852–1927): American educator and cnidarian biologist." Archives of Natural History 36, no. 2 (October 2009): 244–61. http://dx.doi.org/10.3366/e0260954109000977.
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Charles Wesley Hargitt was born near Lawrenceburg, Indiana, USA, and died at Syracuse, New York. After a brief career as a Methodist Episcopal minister, he carried out graduate studies in biology at Illinois Wesleyan University and Ohio University. He served briefly on the faculty at Moores Hill College and later at Miami University of Ohio before receiving an appointment at Syracuse University. Hargitt spent 36 years at Syracuse, and for 21 years was a trustee of the Marine Biological Laboratory, Woods Hole, Massachusetts. His research encompassed animal behaviour, cell biology, development, ecology, natural history, and taxonomy, as well as education, eugenics, and theology, and he wrote or contributed to more than 100 publications in science. Approximately half of these were on Cnidaria, with 41 of them on Hydrozoa. His most important works in hydrozoan taxonomy were on species of the Woods Hole region, the Philippines, and south China. Hargitt was author of three genera and 48 species and subspecies ascribed to Hydrozoa, seven species of Anthozoa, and one species of Cubozoa. Four species of hydroids are named in his honour.
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Graham, John B., and Brian C. McCarthy. "Forest floor fuel dynamics in mixed-oak forests of south-eastern Ohio." International Journal of Wildland Fire 15, no. 4 (2006): 479. http://dx.doi.org/10.1071/wf05108.
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Silvicultural treatments alter fuel dynamics in forested systems, which may alter fire regime. Effects of thinning and prescribed fire on forest-floor fuels were studied in mixed-oak forests of south-eastern Ohio to examine fuel dynamics over time. Fuel characteristics were measured before, immediately after, and 3 years following fire and thinning treatments along 20-m transects (n = 432) following Brown’s planar intersect method. Measurements were taken to determine litter, duff, 1-h, 10-h, 100-h, and 1000-h sound (1000S) or rotten (1000R) fuel mass. Coarse woody debris (CWD) was sampled on 432 additional 80-m2 belt-transects. Repeated-measures analysis of variance with post-hoc Bonferonni comparisons was used to analyse the change in the fuels over time. The specific effects of silvicultural treatments varied over time with changes in larger, sound fuels (1000S and CWD) persisting longer than changes to finer (litter, duff, 1-h, 10-h, and 100-h) or less-sound (1000R) fuels, which appear to be more transient. Unlike in western North America where fuels accumulate over time, decomposition and productivity appear comparable in eastern mixed-oak forests. Aside from their impact on decomposition or productivity rates, silvicultural treatments appear to have little impact on fine-fuel loading in these systems.
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Hannibal, Joseph T., Michael E. Williams, and Gary L. Jackson. "An inexpensive source of dolomite powder for use with airbrasive units." Journal of Paleontology 62, no. 2 (March 1988): 316. http://dx.doi.org/10.1017/s002233600003002x.
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In the past few years the Cleveland Museum of Natural History has received several inquiries as to our source of dolomite for use with S.S. White® industrial airbrasive units. We have been using inexpensive, “agricultural” dolomite with these units for several years. This source was “discovered” by testing of a wide variety of dolomite sources by Peter Kotulak, a former preparator at the Museum, under the direction of M.E.W. We are currently using OHSO® Pulverized Limestone, a kiln-dried dolomitic limestone recommended for agricultural, and lawn and garden, use. It is produced by the Ohio® Lime Co., of Woodville, Ohio. A 22.7 kg (50 pound) bag costs $2.25, and is available at building supply companies. The dolomite must be sieved and dried to prevent clogging of the unit's line and nozzle. We use a Ro-Tap® Testing Sieve Shaker to sieve the material, with #30 (595 micron), #60 (250 micron), and #100 (150 micron) U.S.A. standard testing sieves. An incandescent desk lamp can be placed over an open container of the sieved dolomite to keep it dry. Used powder may be re-sieved for reuse if desired.
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Graham, Gary W., P. Charles Goebel, Randall B. Heiligmann, and Matthew S. Bumgardner. "Influence of Demographic Characteristics on Production Practices within the Ohio Maple Syrup Industry." Northern Journal of Applied Forestry 24, no. 4 (December 1, 2007): 290–95. http://dx.doi.org/10.1093/njaf/24.4.290.
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Abstract Maple syrup production contributes approximately $5 million annually to Ohio's economy and provides supplemental nontimber forest product income for forestland owners. To better understand the factors that influence this important nontimber forest industry in Ohio, including producer heritage, producer age, sap collection methods, size of maple operation, and educational programming, we conducted a detailed survey of all known Ohio maple syrup producers (761 total producers). Over 80% of producers responded to the survey (620 respondents), making our analysis one of the most extensive of a maple industry in North America. In general, most maple operations in Ohio are part-time, family-based enterprises and over 25% of Ohio's maple producers are of Amish heritage. Although we estimate that there are over 400,000 taps in the state, the typical sugarbush is relatively small—the average sugarbush is 27 ac in size and over a third of the operations have fewer than 100 taps. Chi-square analyses did reveal several significant (α = 0.05) associations among producer characteristics. Although Amish producers were significantly younger and had significantly larger operations than their English or non-Amish counterparts (P < 0.001), a higher proportion of English producers reported using tubing collection systems than Amish producers (P = 0.031). Additionally, while larger maple operations tended to use tubing systems more frequently (P < 0.001), we did not detect a significant association between sap collection method (bucket versus tubing) and producer age (P = 0.169). Finally, English producers tend to be older. Older producers (>53 years old), producers using tubing collection systems, and producers with more than 250 taps were significantly more likely to participate in Ohio State University (OSU) Extension educational programming (P ≤ 0.05). These results suggest significant relationships among producer demographics and the characteristics of maple operations in Ohio, and future OSU educational programming should be tailored to reflect these important relationships.
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Holmes, Marion A., and Glenn R. Matlack. "Agricultural history drives structure and tree species composition of second growth forest over 100 years in southeastern Ohio, USA." Journal of Vegetation Science 28, no. 4 (April 12, 2017): 736–46. http://dx.doi.org/10.1111/jvs.12516.
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Williams, Roger A., and Yuhua Tao. "A Carbon Management Diagram for Oak-hickory Forests in Southern Ohio." Northern Journal of Applied Forestry 28, no. 3 (September 1, 2011): 161–65. http://dx.doi.org/10.1093/njaf/28.3.161.
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Abstract A carbon management diagram for use in oak-hickory forests in southern Ohio has been developed to allow easier quantification of total forest carbon stock. The total carbon stock is positively correlated to basal area and average stand diameter but poorly correlated to the number of trees per acre. The total amount of carbon stored in these forests is going to be influenced by age and site quality to the extent that age and site influence basal area and the average tree size. Accordingly, not all stands considered to be fully to overstocked store the most carbon. Rather, it is a combination of basal area and average tree size that determines the total carbon stored, with the carbon stock in the forest increasing with an increase in both basal area and average tree diameter. Examples illustrating the use of the diagram are presented for two oak forests on oak site indexes 60 and 80. Both forests are overstocked at age 100 years, but the forest on site index 60 stores 77 tons/ac of total carbon compared with 103 tons/ac on site index 80.
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Erjavec, James L. "A New Map of Pleistocene Proglacial Lake Tight Based on GIS Modeling and Analysis." Ohio Journal of Science 118, no. 2 (December 5, 2018): 57. http://dx.doi.org/10.18061/ojs.v118i2.6548.
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Glacial-age Lake Tight was first mapped by John F. Wolfe in 1942. Wolfe compiled his map from photographs of 50 USGS topographic maps, and used the 900-foot contour to delineate its shoreline. An estimate, as reported by Hansen in 1987, suggested an area of approximately 18,130 km2 (7,000 mi2) for the lake. Using a geographic information system (GIS) environment, an updated map of Lake Tight was developed employing the 275-meter (902-foot) elevation contour. Calculations now suggest the area of Lake Tight was 43 percent larger or approximately 26,000 km2 (10,040 mi2) and the volume approximately 1,120 km3 (268 mi3). The reconstruction of Lake Tight in a GIS creates a spatial analysis platform that can support research on the origin and development of the lake, the geologic processes that occurred as a consequence of the advance of the pre-Illinoian ice, and the origin of the Ohio River. The development of the upper Ohio Valley during the Quaternary Period remains one of the outstanding problems in North American geology. The details of the transition from the Teays River to Lake Tight, and from Lake Tight to the Ohio River, are poorly understood despite more than 100-years passing since the first significant study of those changes. A refined understanding of the area and depth of Lake Tight is essential but is complicated by fundamental unknowns—such as the location of the pre-Illinoian ice margin and the extent and consequence of isostatic flexure of the lithosphere due to ice-loading and lake-loading. Given the assumptions required for the model, the accuracy of both the raster data and the 1942 topographic maps, and the paucity of essential field data, mapping the lake shoreline at the widely cited 274.32-meter (900-foot) contour would not provide increased verifiable accuracy.
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Werman, Howard A., Timothy Erskine, Jeffrey Caterino, Jane F. Riebe, and Tricia Valasek. "Development of Statewide Geriatric Patients Trauma Triage Criteria." Prehospital and Disaster Medicine 26, no. 3 (June 2011): 170–79. http://dx.doi.org/10.1017/s1049023x11006315.
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AbstractIntroduction: The geriatric population is unique in the type of traumatic injuries sustained, physiological responses to those injuries, and an overall higher mortality when compared to younger adults. No published, evidence-based, geriatric-specific field destination criteria exist as part of a statewide trauma system. The Trauma Committee of the Ohio Emergency Medical Services (EMS) Board sought to develop specific criteria for geriatric trauma victims.Methods: A literature search was conducted for all relevant literature to determine potential, geriatric-specific, field-destination criteria. Data from the Ohio Trauma Registry were used to compare elderly patients, defined as age >70 years, to all patients between the ages of 16 to 69 years with regards to mortality risk in the following areas: (1) Glasgow Coma Scale (GCS) score; (2) systolic blood pressure (SBP); (3) falls associated with head, chest, abdominal or spinal injury; (4) mechanism of injury; (5) involvement of more than one body system as defined in the Barell matrix; and (6) co-morbidities and motor vehicle collision with one or more long bone fracture. For GCS score and SBP, those cut-off points with equal or greater risk of mortality as compared to current values were chosen as proposed triage criteria. For other measures, any criterion demonstrating a statistically significant increase in mortality risk was included in the proposed criteria.Results: The following criteria were identified as geriatric-specific criteria: (1) GCS score <14 in the presence of known or suspected traumatic brain trauma; (2) SBP <100 mmHg; (3) fall from any height with evidence of traumatic brain injury: (4) multiple body-system injuries; (5) struck by a moving vehicle; and (6) the presence of any proximal long bone fracture following motor vehicle trauma. In addition, these data suggested that elderly patients with specific co-morbidities be given strong consideration for evaluation in a trauma center.Conclusions: The state of Ohio is the first state to develop evidence-based geriatric-specific field-destination criteria using data from its state-mandated trauma registry. Further analysis of these criteria will help determine their effects on over-triage and under-triage of geriatric victims of traumatic injuries and the impact on the overall mortality in the elderly.
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Kriss, A. B., P. A. Paul, and L. V. Madden. "Relationship Between Yearly Fluctuations in Fusarium Head Blight Intensity and Environmental Variables: A Window-Pane Analysis." Phytopathology® 100, no. 8 (August 2010): 784–97. http://dx.doi.org/10.1094/phyto-100-8-0784.
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Window-pane methodology was used to determine the length and starting time of temporal windows where environmental variables were associated with annual fluctuations of Fusarium head blight (FHB) intensity in wheat. Initial analysis involved FHB intensity observations for Ohio (44 years), with additional analyses for Indiana (36 years), Kansas (28 years), and North Dakota (23 years). Selected window lengths of 10 to 280 days were evaluated, with starting times from approximate crop maturity back to the approximate time of planting. Associations were quantified with Spearman rank correlation coefficients. Significance for a given variable (for any window starting time in a collection of starting times) was declared using the Simes' multiplicity adjustment; at individual time windows, significant correlations were declared when the individual (unadjusted) P values were <0.005. In all states, moisture- or wetness-related variables (e.g., daily average relative humidity [RH] and total daily precipitation) were found to be positively correlated with FHB intensity for multiple window lengths and starting times; however, the highest correlations were primarily for shorter-length windows (especially 15 and 30 days) at similar starting times during the final 60 days of the growing season, particularly near the time of anthesis. This period encompasses spore production, dispersal, and fungal colonization of wheat spikes. There was no evidence of significant correlations between FHB and temperature-only variables for any time window; however, variables that combined aspects of moisture or wetness with temperature (e.g., duration of temperature between 15 and 30°C and RH ≥ 80%) were positively correlated with FHB intensity. Results confirm that the intensity of FHB in a region depends, at least in part, on environmental conditions during relatively short, critical time periods for epidemic development.
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Rinehardt, Hannah, Evan Morgan, Mahmoud Kassem, Marilly Palettas, Abdul Miah, Iyad Alnahhas, Pilar Guillermo Prieto Eibl, et al. "Assessment of Leptomeningeal Carcinomatosis Diagnosis and Outcomes from 2005 to 2015 at Ohio State University." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e13554-e13554. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e13554.
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e13554 Background: Leptomeningeal carcinomatosis (LMC) is a complication of advanced malignancies wherein primary tumors metastasize to the leptomeninges surrounding brain and spinal cord. LMC complicates 4-15% of malignant solid tumors with incidence increasing as survival of patients with advanced cancer improves. Diagnostic methods include magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology. MRI findings may be nonspecific, and the gold standard of diagnosis is malignant cytology on CSF analysis. We assessed detection methods, incidence, and outcomes of LMC at The Ohio State University Comprehensive Cancer Center from 2005-2015. Methods: This was an IRB-approved single-institution retrospective study of 160 patients with confirmed diagnosis of LMC who were treated at the OSUCCC-James between Jan 1, 2005 and Dec 31, 2015. Patients with hematologic and central nervous system malignancies were excluded. Descriptive statistics were used to summarize demographic and clinical characteristics. Overall survival (OS) was defined as time from LMC diagnosis to death or last known follow-up, and was generated using Kaplan-Meier methods. Results: Median age of LMC diagnosis was 55.8 years (range: 48, 62.5). 69 (43%) patients had primary breast cancer, 41 (26%) had lung cancer, and 17 (11%) had melanoma. 73 patients (46%) presented with stage IV disease at initial diagnosis of the primary cancer, 41 (26%) with stage III disease, and 26 (16%) with stage II disease. Median time from diagnosis of primary cancer to diagnosis of LMC was 2 years (range: 0, 31.2). 158 (99%) patients had metastases at the time of LMC diagnosis, predominantly in bone (36%) or brain (36%). Median OS was 1.9 months (CI: 1.3, 2.5). 160 (100%) patients had an MRI of the brain or spine and 155 (97%) had MRI findings consistent with LMC. 75 (47%) patients underwent lumbar puncture, and 39 (52%) had CSF cytology positive for malignancy. Conclusions: Patients with LMC commonly presented with stage IV breast cancer, lung cancer, or melanoma with metastases to the brain or bone. Despite treatment, prognosis remains poor and confirmation of diagnosis can be challenging. Clinicians should have a low threshold for investigating LMC in high risk patients presenting with neurologic signs or symptoms.
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Williams, Nicole, Hannah Rinehardt, Evan Morgan, Mahmoud Kassem, Marilly Palettas, Vinay Puduvalli, Pierre Giglo, et al. "LPTO-10. ASSESSMENT OF LEPTOMENINGEAL CARCINOMATOSIS DIAGNOSIS AND OUTCOMES FROM 2005 TO 2015 AT THE OHIO STATE UNIVERSITY." Neuro-Oncology Advances 1, Supplement_1 (August 2019): i8. http://dx.doi.org/10.1093/noajnl/vdz014.033.
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Abstract BACKGROUND: Leptomeningeal carcinomatosis (LMC) is a complication of solid tumor malignancies where tumors metastasize to the leptomeninges. LMC complicates 4–15% of malignancies with incidence increasing as survival of patients with advanced cancer improves. Diagnostic methods include magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology. We assessed detection methods, incidence, and outcomes of LMC at The Ohio State University Comprehensive Cancer Center from 2005–2015. METHODS: This was a single-institution retrospective study of 160 patients with confirmed diagnosis of LMC. Patients with hematologic and central nervous system malignancies were excluded. Descriptive statistics were used to summarize demographic and clinical characteristics. Overall survival (OS) was defined as time from LMC diagnosis to death or last known follow-up, and was generated using Kaplan-Meier methods. RESULTS: Median age of LMC diagnosis was 55.8 years (range: 48, 62.5). 69 (43%) patients had primary breast cancer, 41 (26%) had lung cancer, and 17 (11%) had melanoma. 73 patients (46%) presented with stage IV disease at initial diagnosis of the primary cancer, 41 (26%) with stage III disease, and 26 (16%) with stage II disease. Median time from diagnosis of primary cancer to diagnosis of LMC was 2 years (range: 0, 31.2). 158 (99%) patients had metastases at the time of LMC diagnosis, predominantly in bone (36%) or brain (36%). Median OS was 1.9 months (CI: 1.3, 2.5). 160 (100%) patients had an MRI of the brain or spine and 155 (97%) had MRI findings consistent with LMC. 75 (47%) patients underwent lumbar puncture, and 39 (52%) had CSF cytology positive for malignancy. CONCLUSIONS: Despite treatment, prognosis remains poor and confirmation of diagnosis can be challenging. This study highlights the need for novel therapeutics and improved diagnostic techniques for patients with LMC.
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Flinders, Brooke A. "Improving Quality in Teen Pregnancy Prevention Through Effective Replication: A Mixed Methods Focus on Fidelity." Journal of Doctoral Nursing Practice 10, no. 2 (2017): 149–54. http://dx.doi.org/10.1891/2380-9418.10.2.149.
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Fidelity monitoring is an essential component of evidence-based replication in teen pregnancy prevention. Fidelity toolkits ensure that core curriculum is adhered to, by providing a detailed checklist of expected activities. When systematically reviewed, fidelity toolkits offer critical information on challenges and barriers that can inform and improve future programming. The purpose of this project was to implement an educational program to improve sexual health in teens, using a fidelity toolkit to promote and evaluate program fidelity. Participants, from a suburban Ohio county, included faculty, junior-level baccalaureate nursing students, and females, 15–19 years of age. Plan-do-study-act methodology was used to carry out this quality improvement initiative. Twenty-three nursing students, divided among 3 clinical sections, and their 3 faculty members completed the fidelity toolkits. Part I fidelity ranged from 82.73% to 100% (M = 97.8%), Part II fidelity ranged from 75% to 95.83% (M = 92.76%), Part III fidelity ranged from 81.5% to 95.83% (M = 91.8%), and Part IV fidelity ranged from 57% to 100% (M = 98.2%). Overall, fidelity of the program averaged 96.4%. Several themes were identified as a result of the qualitative analysis of narrative toolkit responses, in the categories of participant factors, site factors, and presenter factors. Toolkit use led to a high level of program fidelity.
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van der Wiel, Karin, Sarah B. Kapnick, Gabriel A. Vecchi, James A. Smith, P. C. D. Milly, and Liwei Jia. "100-Year Lower Mississippi Floods in a Global Climate Model: Characteristics and Future Changes." Journal of Hydrometeorology 19, no. 10 (October 1, 2018): 1547–63. http://dx.doi.org/10.1175/jhm-d-18-0018.1.
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AbstractFloods in the Mississippi basin can have large negative societal, natural, and economic impacts. Understanding the drivers of floods, now and in the future, is relevant for risk management and infrastructure-planning purposes. We investigate the drivers of 100-yr-return lower Mississippi River floods using a global coupled climate model with an integrated surface water module. The model provides 3400 years of physically consistent data from a static climate, in contrast to available observational data (relatively short records, incomplete land surface data, transient climate). In the months preceding the model’s 100-yr floods, as indicated by extreme monthly discharge, above-average rain and snowfall lead to moist subsurface conditions and the buildup of snowpack, making the river system prone to these major flooding events. The meltwater from snowpack in the northern Missouri and upper Mississippi catchments primes the river system, sensitizing it to subsequent above-average precipitation in the Ohio and Tennessee catchments. An ensemble of transient forcing experiments is used to investigate the impacts of past and projected anthropogenic climate change on extreme floods. There is no statistically significant projected trend in the occurrence of 100-yr floods in the model ensemble, despite significant increases in extreme precipitation, significant decreases in extreme snowmelt, and significant decreases in less extreme floods. The results emphasize the importance of considering the fully coupled land–atmosphere system for extreme floods. This initial analysis provides avenues for further investigation, including comparison to characteristics of less extreme floods, the sensitivity to model configuration, the role of human water management, and implications for future flood-risk management.
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Selhorst, Mitchell, Alicia Fernandez-Fernandez, and M. Samuel Cheng. "Rasch analysis of the anterior knee pain scale in adolescents with patellofemoral pain." Clinical Rehabilitation 34, no. 12 (July 17, 2020): 1512–19. http://dx.doi.org/10.1177/0269215520942950.
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Objective: The aim of this study was to evaluate the Anterior Knee Pain Scale in a cohort of adolescents being treated conservatively for patellofemoral pain using Rasch analysis. Design: This is a psychometric study. Setting: Physical therapy clinics of a large pediatric hospital in Columbus, Ohio (United States) Subjects: A total of 646 adolescent patients with patellofemoral pain (76% female, 14.6 ± 1.6 years old). Intervention: Not applicable. Main Measure: The Anterior Knee Pain Scale. Results: The median Anterior Knee Pain Scale score was 73 (interquartile range 64–81), with scores ranging from 7 to 100 on the 100-point scale. The Rasch person reliability for the Anterior Knee Pain Scale was 0.74 and the Cronbach’s alpha was 0.75, representing an acceptable person reliability. Principal component analysis revealed a ratio of 5.2:1 demonstrating acceptable unidimensionality of the Anterior Knee Pain Scale. A significant misfit was observed in the item “Abnormal Painful Kneecap Movements” (Outfit Means Square 2.74, Infit Means Square 1.41). Ordering of item responses was unsatisfactory as only five of the 13 items demonstrated appropriate distinction between each of the responses. There was no differential item functioning for sex or age for all items of the Anterior Knee Pain Scale, based upon the criterion of ⩾ 0.5 logit difference. Conclusion: The Anterior Knee Pain Scale does not meet interval-level measurement criteria and should be considered ordinal level data.
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Bowyer, Stuart, Dan Werthimer, Charles Donnelly, Jeff Cobb, David Ng, and Michael Lampton. "Twenty Years of Serendip, The Berkeley Seti Effort: Past Results and Future Plans." International Astronomical Union Colloquium 161 (January 1997): 667–76. http://dx.doi.org/10.1017/s0252921100015220.
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AbstractThe Berkeley SETI effort has been ongoing for more than twenty years. During this period we have carried out extensive SETI searches, but of at least equal importance, we have been on the forefront of instrumentation development, the development of interference rejection and detection algorithms, and educational efforts. Our instrumentation has evolved from a 100 channel spectrometer (SERENDIP I) to our latest machine (SERENDIP IV) with 168 million channels. In addition to supporting our SETI work, our hardware has been used by NASA for RFI surveys and to check the Mars Survey relay transmitter. Our designs have influenced several of the major SETI hardware systems, and a SERENDIP III system is currently being used in the Ohio State SETI group. Our hardware has also been incorporated in pulsar instrumentation at NAIC (Arecibo), NRAO (Greenbank) and Bonn, Germany. We have just completed a 4 year search at the world’s largest radio telescope at Arecibo. We covered 93% of the observable sky at least once, and 44% of the sky at least 5 times, with a sensitivity of ~ 3 × l0−25Wm−2. We collected and analyzed information from over 1014spectral bins and logged and analyzed over 2 × 108signals of potential special interest. We have developed extensive analysis programs to identify and remove interference and to search for signal characteristics which are expected from an extraterrestrial signal. Our algorithms were successful in removing all but 0.01% of spurious RFI in the Arecibo data set. We have involved over 30 undergraduate and graduate students in our effort, and 5 Master's theses have been awarded for work on the SERENDIP project. Our next effort will use our SERENDIP IV hardware at Arecibo Observatory to carry out a 21 cm survey of the Arecibo sky.
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Ruan, Dijiao, Xu Tang, Xiaoli Li, Lianlian Li, and Jing Hua. "Trends and bibliometric analysis on pediatric anesthesia from 2002 to 2022: A review." Medicine 102, no. 43 (October 27, 2023): e35626. http://dx.doi.org/10.1097/md.0000000000035626.
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Pediatric anesthesia is one of the most concerning topics in our society. However, there is still a lack of a comprehensive overview of the research base and of future trends. This study aimed to guide beginners quickly learn the academic research on pediatric anesthesia and do their own studies by analyzing the articles of this field in the latest 21 years through bibliometric analysis. Literature scanning was conducted with the Web of Science database. Microsoft Excel, SPSS, VOSviewer, and CiteSpace were in this review. There was an increasing trend of articles on pediatric anesthesia, based on the analysis of 11,591 included articles. The top 3 most productive countries were the United States of America (4538), Canada (730) and Turkey (688). The most productive institutions were Boston Childrens hospital, Childrens Hospital Philadelphia and Ohio State University. Tobias, Joseph D (141), Kim, Hee-Soo (40) and Curley, Martha A Q (38) were the most active authors. Habre W (2017), Gross JB (2002) and Cravero JP (2009) are the articles cited more than 100 times during the analysis years. Anesthesia and Analgesia, Anesthesiology, Pediatric Anesthesia, were the core journals in this field. Cohort, simulation, sleep, postoperative complication are strongest burst keywords in recent years. This article summarizes the authoritative institutions, authors, literatures and frontier hotspots on pediatric anesthesia. Itwill be a valuable literature review and help beginners to quickly get started in the field, reduce unnecessary clueless and aimless learning, and greatly improve learning efficiency.
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Szilagyi, S. Jean. "Staff Training and Stress in Long Term Care Facilities Special Care Units for Alzheimer's Elders." Magyar Gerontológia 13 (December 29, 2021): 43–44. http://dx.doi.org/10.47225/mg/13/kulonszam/10582.
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Objective:Special Care Units (SCU) in long term care health facilities are named to indicate "unique to diagnosis" or a level of care. The purpose of this study was to explore perceptions among caregivers and licensed nurses in selected nursing homes in Ohio and Pennsylvania and New York, as they pertained to the differences in care to Alzheimer's elders in SCUs. It examined the education and experience of staff and the satisfaction of this staff as it pertained to stress and wages.
Background:Long-term caregivers often experience stress, resulting in "burn-out" as a consequence of limited training, levels of care required, cognitive decline of elders and family expectations. The caregivers, on SCUs, environmentally designed for the elders with cognitive decline, need specialized training in the physical and mental dimensions of the various forms of dementia, Alzheimer's type.
Methods:The study used a qualitative research design with a survey questionnaire and one-on-one interviews with administrators and human resource directors. A pilot study of SCUs in Ohio and Pennsylvania and New York was initiated. The population was the employees of these SCU. The levels of employees questioned included: Executive director/Administrator, nurses, nurse aides, housekeepers and activities staff, laundry and social service workers. The procedure was standardized to enhance the reliability of the data. The respondents were notified in advance of the specific application of their answers and were afforded the opportunity to receive a monetary donation to the SCU of their respective facilities.An Eden Alternative Home, with a program of goals and missions characterizing enhancement of an elder's life, a home-like environment and family-centered staff and care, in a very rural area of Pennsylvania, was also engaged to contrast and compare the hypotheses of the study.
Results:On the SCU, less than 5 percent of the staff had received training specific to the care of the Alzheimer's elders. In the Eden Home, 100 percent of the staff had received training specific to the care of the Alzheimer's elders. On the SCU, less than 18 percent were satisfied with the quality and quantity of specialized and extensive training. In the Eden Home, 100 percent of the staff was satisfied with their specific training. On the SCU, using a Leiken scale, more than 55 percent felt that they should receive higher wages. In the Eden home, the results were the same. However, the longevity of the employees was 13.5 years as opposed to only 3.25 years in the SCU in other homes.
Conclusion:These findings suggest there is a need to examine, expand and intensify the training of all caregivers on a special unit for the elders afflicted with dementia, Alzheimer's type.
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Berger, Annette M. "Akron, Ohio – a high solids anaerobic digestion process replaces a successful In-Vessel composting operation." Water Practice and Technology 11, no. 2 (June 1, 2016): 396–412. http://dx.doi.org/10.2166/wpt.2016.048.
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For 26 years, the City of Akron had been managing their wastewater solids using the in-vessel Paygro Composting process. While the operations of the facility and the marketing of the finished compost was successful, the concern by the public over the odor generation, the steadily increasing operational costs and the need for a large capital investment to continue composting, as a result of the facility showing its years of wear from the operations, was the reason for the City to move forward with building a new 13,607 dry t (15,000 dry ton) anaerobic digestion (AD) plant. The new 13,607 dry t (15,000 dry ton) AD plant modeled the 4535 dry t (5000 dry ton) Schmack BioGas AG AD plant built in 2007, which was used to validate the operational process and understand the biogas generation prior to going full scale. With the success of the 4535 dry t (5000 dry ton) AD plant, the City in 2011 entered into a long term contract with KB BioEnergy (formerly KB Compost) to build and operate the new 13,607 dry t (15,000 dry ton) (AD) plant on the same grounds that the composting facility existed now known as the Akron Renewable Energy Facility. The $32M plant would use the BIOFerm Energy Systems/Schmack BioGas AD technology. Three 600 kW MWM all-in-one packages from 2-G Cenergy were purchased to convert the biogas to electricity. In addition, an indirect paddle dryer by Komline Sanderson was installed to further process the solids coming out of the AD plant to produce material suitable for market. Construction of the facility began in September of 2011 with the plant being operational by the end of 2013. To process the solids anaerobically, two 1000 cubic meter Eucos (horizontal plug flow tanks) and two 3000 cubic meter Coccus' (complete mix tanks) were constructed. One Euco and one Coccus act as a train capable of processing 6803 dry t (7500 dry tons) of solids. The feedstock consists of a liquid stream entering the Euco tanks at 5% solids and the solids stream where the dewatered sludge enters at 28–30% solids. Maintaining a temperature between 35°C and 37.8°C (95°F and 100°F) in the tanks, the material is slowly moved thru the Euco over the next 8 days where 50% of the biogas production occurs. The digested solids are then transferred to the Coccus where the retention time is approximately 20 days prior to being discharged to holding tanks. Material entering the holding tanks is between 9 and 11% solids. The digestate is then dewatered using centrifuges. This dewatered digestate cake is then the feedstock for the dryer where the solids enter at approximately 30% and leave at ≥92% solids. The biogas production from the process is approximately 11.3 m³/min (400 cfms). This biogas can be used to fuel the three 600 kW MWM engines or the thermal boilers used with the dryer or a combination of both depending on the need. With some of the biogas used in the thermal boilers, a biogas conditioning skid by Unison Solutions was installed that removes hydrogen sulfide, siloxanes if present and moisture. Normal operations result in the biogas being consumed by the engines with a power production of 1.2MW of electric capacity and 1.3MW of thermal capacity. An enclosed flare was installed to manage up to 17.0 m³/min (600 cfms) of biogas. After one year of operations, the 13,607 dry t (15,000 dry ton) AD plant has been able to process all the sludge generated by the Akron Water Reclamation Facility successfully. On average 12.0 m³/min (425 cfms) of biogas have been produced resulting in 1048 kWh generated or 87% design capacity. This paper will take a closer look at the operational numbers as well as the challenges that occurred along the way of commissioning the facility.
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Lawrimore, Jay, Thomas R. Karl, Mike Squires, David A. Robinson, and Kenneth E. Kunkel. "Trends and Variability in Severe Snowstorms East of the Rocky Mountains*." Journal of Hydrometeorology 15, no. 5 (September 25, 2014): 1762–77. http://dx.doi.org/10.1175/jhm-d-13-068.1.
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Abstract The 100 most severe snowstorms within each of six climate regions east of the Rocky Mountains were analyzed to understand how the frequency of severe snowstorms is associated with seasonal averages of other variables that may be more readily predicted and projected. In particular, temperature, precipitation, and El Niño/La Niña anomalies from 1901 to 2013 were studied. In the southern United States, anomalously cold seasonal temperatures were found to be more closely linked to severe snowstorm development than in the northern United States. The conditional probability of occurrence of one or more severe snowstorms in seasons that are colder than average is 80% or greater in regions of the southern United States, which was found to be statistically significant, while it is as low as 35% when seasonal temperatures are warmer than average. This compares with unconditional probabilities of 55%–60%. For seasons that are wetter (drier) than average, severe snowstorm frequency is significantly greater (less) in the Northern Plains region. An analysis of the seasonal timing of severe snowstorm occurrence found they are not occurring as late in the season in recent decades in the warmest climate regions when compared to the previous 75 years. Since 1977, the median date of occurrence in the last half of the cold season is six or more days earlier in the Southeast, South, and Ohio Valley regions than earlier in the twentieth century. ENSO conditions also were found to have a strong influence on the occurrence of the top 100 snowstorms in the Northeast and Southeast regions.
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Barnes, C. W., L. J. Szabo, and V. C. Bowersox. "Identifying and Quantifying Phakopsora pachyrhizi Spores in Rain." Phytopathology® 99, no. 4 (April 2009): 328–38. http://dx.doi.org/10.1094/phyto-99-4-0328.
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In summers of 2005 and 2006, rain was collected weekly at over 100 selected National Atmospheric Deposition Program/National Trends Network sites across the soybean-growing region of the central and eastern United States. Rain samples were screened for Phakopsora pachyrhizi (causal agent of soybean rust) DNA using a nested real-time polymerase chain reaction assay. Over this time frame, P. pachyrhizi spores were detected in every state in the study, but more frequently in states along the Gulf and Atlantic coasts and along the Ohio River Valley westward to Kansas. A bimodal temporal distribution of samples testing positive for P. pachyrhizi was found in both years. However, there was a greater than threefold increase in the number of samples testing positive for P. pachyrhizi in 2006 compared with 2005, with the most significant increase in August. There was also an increase in the average number of spores per sample in 2006 relative to 2005. Sequence analysis of a subset of positive samples was used to validate the assay results. From the sequence analysis, two reliable polymorphic regions were found, resulting in six distinct genotypes. One genotype was found in 56% of the samples tested, whereas the other genotypes were found less frequently.
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Madden, Gwyn D., Sango Otieno, and Jordan Karsten. "Assessing the Occipital Condyles for Age Estimation of Non-Adults." Anthropology – Open Journal 5, no. 2 (December 30, 2022): 31–42. http://dx.doi.org/10.17140/antpoj-5-129.
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Objectives New methods for assessing age of non-adult remains are frequently sought to improve the ability to correctly identify individuals in for forensic and archaeological purposes. Especially when faced with comingled remains, it is helpful to have a bone appropriate tool for age estimation. Research was carried out to assess the usefulness of the occipital condyles for aging non-adult individuals using metric and morphology analyses. The research population included occipital condyles, both fused and unfused, of individuals of known age at death non-adult from the from the Hamann-Todd Collection, Museum of Natural History, Cleveland, Ohio, USA (N=69); Colecção Esqueletos Identificados, Natural History Museum, University of Coimbra, Portugal (N=113); Museu Bocage, National Museum of Natural History, Lisbon, Portugal (N=60). Length and width measurements were taken then regression was used to analyse the datasets. Three morphological factors were observed including, level of fusion at the synchondrosis intraoccipitalis anterior, presence/absence of billows and presence/absence of depressions. Results Accuracy based on the metric model ranged between 37-71%. The morphological model showed fusion present as early as 3-years of age, with all non-adults over 8-years showing 100% complete fusion. Only individuals below 13-years of age displayed billows or depressions present; presence not absence of the morphological variables can be used to estimate age with a 92% accuracy rate. Conclusion The metric model does not reach an acceptable level of accuracy for use in aging non-adults. Morphology of the occipital condyles do not follow a specific age progression but can be used as a quick age assessment guide; if these morphological features are present the individual very likely between 3-13-years of age.
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Creary, Susan E., Deena J. Chisolm, Sharon K. Wrona, and Jennifer N. Cooper. "Opioid Prescription Filling Trends Among Children with Sickle Cell Disease After the Release of State-Issued Guidelines on Pain Management." Pain Medicine 21, no. 10 (March 6, 2020): 2583–92. http://dx.doi.org/10.1093/pm/pnaa002.
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Abstract Objective To assess the impact of Ohio’s 2012, 2013, and 2016 opioid prescribing guidelines on opioid and nonsteroidal anti-inflammatory drug (NSAID) prescription filling and health care utilization for pain among children with sickle cell disease (SCD). Design Quasi-experimental retrospective cohort study. Setting Ohio Medicaid claims data from August 2011 to August 2016. Subjects Medicaid beneficiaries under age 19 years with SCD. Methods Interrupted time series analyses comparing population-level rates of opioids and NSAID prescriptions filled, standardized amounts of opioids dispensed, and acute health care utilization for pain before and after release of each guideline. Results In our cohort of 1,505 children with SCD, there was a temporary but significant decrease in the opioid filling rate (–2.96 prescriptions per 100 children, P = 0.01) and in the amount of opioids dispensed (–31.39 milligram morphine equivalents per filled prescription, P < 0.001) after the 2013 guideline but a temporary but significant increase in the opioid filling rate (7.44 prescriptions per 100 children, P < 0.001) and in the amount of opioids dispensed (72.73 mg morphine equivalents per filled prescription, P < 0.001) after the 2016 guideline. The NSAID filling rate did not significantly change after any of the guidelines. Acute health care utilization rates for pain after the 2016 guideline were similar to those before the 2013 guideline (rate ratio = 1.04, P = 0.63). Conclusions Our results suggest that Ohio’s 2013 and 2016 guidelines were associated with significant but nonsustained changes in opioid prescription filling among children with SCD. Additional studies are needed to confirm that opioid guidelines have a sustained impact on excessive opioid prescribing, filling, and misuse.
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Hasan, Muhammad Noman, Arwa Fraiwan, Priyaleela Thota, Tolulope Oginni, Grace Mfon Olanipekun, Fatimah Hassan-Hanga, Jane Little, Stephen K. Obaro, and Umut A. Gurkan. "Clinical Testing of Hemechip in Nigeria for Point-of-Care Screening of Sickle Cell Disease." Blood 132, Supplement 1 (November 29, 2018): 1095. http://dx.doi.org/10.1182/blood-2018-99-115355.
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Abstract In sub-Saharan Africa, nearly a quarter of a million babies are born with sickle cell disease (SCD) each year. An estimated 50-90% of these babies die before age 5 due to lack of early diagnosis and timely treatment. The World Health Organization estimates that more than 70% of SCD related deaths are preventable with simple, cost-effective interventions, such as early screening followed by affordable and widely available treatment regimens. Here, we present the early clinical testing results of HemeChip, which is the first single-use cartridge-based microchip electrophoresis hemoglobin screening platform. HemeChip was developed by Hemex Health, Inc., based on technology licensed from Case Western Reserve University. HemeChip allows affordable, objective, quantitative screening of hemoglobin variants at the point-of-care. HemeChip works with a drop of finger or heel-prick blood and separates hemoglobin variants on a piece of cellulose acetate paper that is housed in an injection molded plastic cartridge with a precisely controlled electric field. HemeChip works with a portable reader to produce easily understandable, objective, and quantitative descriptions of the hemoglobin types and percentages present in a blood sample. The HemeChip reader guides the user step-by-step through the test procedure with animated on-screen instructions to minimize user errors. Hemoglobin identification and quantification is automatically done with a custom software on the reader. HemeChip reader records and analyzes the hemoglobin electrophoresis real-time, and it can wirelessly transmit the test results to a central electronic database, if needed. HemeChip prototype units have been clinically tested and benchmarked against the clinical standard technique in Kano, Nigeria, where the SCD prevalence is the highest in the world. We tested a total of 248 subjects (228 children aged 6 weeks to 5 years in Kano, Nigeria; and 20 adults in Cleveland, Ohio, United States) under institutional review board approval, using both HemeChip and the clinical standard laboratory method, High Performance Liquid Chromatography (HPLC, VARIANT™ II, Bio-Rad Laboratories, Inc., Hercules, California). HemeChip tests were done on eHealth Africa campus in Kano, Nigeria, by trained local healthcare workers using blood samples collected at the nearby Aminu Kano Teaching Hospital. Clinical standard (HPLC) testing was done independently by the International Foundation Against Infectious Disease in Nigeria (IFAIN, Abuja, Nigeria) for the blood samples obtained in Kano or by the University Hospitals Cleveland Medical Center Clinical Laboratories (Cleveland, Ohio) for the blood samples obtained in Cleveland. Test results included the following: homozygous SCD (HbSS), heterozygous sickle hemoglobin C disease (HbSC), heterozygous sickle trait (HbAS), and normal (HbAA). HemeChip identified the subjects with HbSS with 100% accuracy, HbSC with 100% accuracy, HbAS with 98.2% accuracy, and HbAA with 96.4% accuracy in comparison to HPLC (Table 1). Overall accuracy of HemeChip was 97.2% in comparison to HPLC for the subjects tested. HemeChip sensitivity was 100% for all hemoglobin variants tested (Table 2), and specificity was 96.4% for HbSS vs. HbAA, 98.2% for HbSS vs. HbAS, 100% for HbSC vs. HbAS, and 100% for HbAS vs. HbAA. Bland-Altman analysis indicated strong agreement between the quantitative HPLC and HemeChip results for hemoglobin percentages, with a mean bias of -3.2%. HemeChip enables, for the first time, accurate, cost-effective identification and quantification of hemoglobin variants at the point-of-need. HemeChip has been developed based on a versatile, mass-producible microchip electrophoresis platform technology that may address other unmet needs in biology and medicine that require rapid, decentralized hemoglobin or protein analysis, identification, and/or quantification. Disclosures Thota: Hemex Health Inc: Employment. Little:PCORI: Research Funding; Hemex: Patents & Royalties: Patent, no honoraria; NHLBI: Research Funding; Doris Duke Charitable Foundations: Research Funding.
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Begley-Miller, Danielle, and Alan Cady. "White-Tailed Deer Browsing of Soybeans Significantly Changes Plant Morphology and Reduces Yield, Contributing to Large Financial Losses." Ohio Journal of Science 115, no. 2 (October 6, 2015): 56. http://dx.doi.org/10.18061/ojs.v115i2.4750.
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White-tailed deer (Odocoileus virginianus) densities in North America have increased significantly in the last 100 years, contributing to extensive agricultural losses. Smaller farming operations are more likely to be impacted by these losses since they generally are not as financially buffered against poor harvests. This study explores changes in plant growth patterns, percent damage, harvest biomass, and yield of a soybean crop from deer browsing at three exposure levels on a small research farm in southwestern Ohio. Experimental soybean plots protected from deer browsing were placed in 0.5 hectare fields during the entire 2010 growing season. Similar, but unprotected, control plots were adjacent to these exclosed areas. The exclosure/control areas were assigned a browse exposure level (high, medium, low) based on their proximity to a wooded area. Individually identified plants were sampled by exposure level and treatment (protected vs. unprotected) in July and August measuring height, width, and percent damage. Yield and above-ground biomass were assessed upon harvest in October. Soybean plants protected from deer browsing were 25 percent taller, 87 percent less damaged, yielded 74 percent more seed, and had 47 percent more above-ground biomass than unprotected plants. Browsing exposure level was not significantly different between enclosed and open plots for any plant parameter. Given per-plant yield results and an average planting density, this farm experienced a loss of $68 (±$32) per hectare to deer. Overall, that represents a $405 (± $214), or 43 percent, financial loss over one growing season.
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Saud, Pradip, Jingxin Wang, Benktesh D. Sharma, and Weiguo Liu. "Carbon impacts of hardwood lumber processing in the northeastern United States." Canadian Journal of Forest Research 45, no. 12 (December 2015): 1699–710. http://dx.doi.org/10.1139/cjfr-2015-0082.
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Carbon emission from hardwood lumber processing in different-sized sawmills under varying energy sources, management strategies, and potential carbon offsetting capacity through useful life (service life) of lumber in the northeastern United States was analyzed using analytical statistics such as analysis of variance (ANOVA), mixed-effect model, principal component analysis, and Monte Carlo simulation. Data obtained from a regional sawmill survey (Pennsylvania, New York, Ohio, and West Virginia), energy audit of sawmills, public databases, and relevant literature were analyzed for the gate-to-gate life cycle inventory framework. Results showed that mean carbon emission (megagrams (Mg) per thousand cubic metres (TCM)) for lumber processing significantly differs among sawmill sizes. The total carbon emission from electricity consumption and wood residue of lumber processing was approximately 62.5%, 80.3%, and 66.2% of carbon stored in lumber processed for small, medium, and large sawmills, respectively. Efficient management and potential opportunities of improvement in sawmills can significantly reduce carbon emission (10.96% ± 1.57%) from hardwood lumber processing. Carbon stock from lumber production could be enhanced by either reducing carbon emission from energy consumption or decreasing lumber export quantity. The carbon emission–loss ratio (CELR) suggested that after 100 years, nearly 50% of carbon stored in lumber would be still available for carbon accountability. Electricity generation from either a single resource (natural gas) or mixed resources as is the case in RFC EAST (eGrid subregion) would be beneficial in lowering carbon emission from sawmill processing.
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McCormack, S., A. Pleister, D. Young, P. Confer, and G. A. Otterson. "A single institution experience of lung cancer treatment in octogenarians." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 18141. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18141.
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18141 Background: In the NCI’s SEER database nearly 15% of NSCLC patients were = 80 years during the years 1973–2003. As the “elderly” population increases, the percentage of octogenarians with NSCLC will increase. To better understand this population we investigated the patient and tumor characteristics and treatment modalities by stage in octogenarians with NSCLC over a recent 5 year period at The Ohio State University Medical Center. Methods: Patients aged 80 years and older with biopsy-proven NSCLC seen between 1998–2003 were included in the analysis. 74 patients met criteria for study. Data was gathered from the cancer registry and chart reviews. Characteristics included stage, histology, treatment, and co-morbid conditions (pulmonary and non-pulmonary co-morbidities, weight loss, and ECOG PS). PS was either explicitly stated or inferred from the records, or recorded as “unknown” when PS could not be determined. Results: The 74 patients averaged 82.8 years of age (range 80–91), with 53% males and 47% females (83 years of age with 56% males and 44% females from the SEER database). 46% of patients had “surgical” disease (Stage IA, IB, and IIB), 20.3% had stage III disease, 29.7% had stage IV disease, and 4.0% had indeterminate staging. 82.4% of “surgical” disease patients received some variety of treatment (70.6% surgery[S], 23.5% radiation[RT], and 12.5% chemo[Ch]); 80% of stage III patients received treatment (53.3% S, 40% RT, and 33.3% Ch); 50% of stage IV patients received treatment (0% S, 31.8% RT, and 40.9% Ch). Patients with an ECOG PS of 0–1, 2, 3–4, or “unknown” equaled 44.6%, 20.3%, 16.2%, and 18.9% respectively with 81.8%, 100%, 41.7%, and 78.6% of these patients receiving treatment. Conclusions: There is little data on treatment of the ‘extreme elderly.‘ Our analysis of this subset of the elderly reveals that most octogenarians seen at a referral center can receive treatment. The majority of “surgical” disease octogenarians received surgical resection of their primary tumor and the majority of all patients received some treatment. Further studies of outcomes based on staging, co-morbidities, and PS will be important in this population. Additional studies of this population in non-referral centers are of interest. No significant financial relationships to disclose.
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Jiang, Justin, Audrey M. Sigmund, Qiuhong Zhao, Patrick Elder, Don M. Benson, Ashley Rosko, Maria Chaudhry, et al. "Trend in Survival in Patients Undergoing Allogeneic Stem Cell Transplantation: An Institutional Experience." Blood 136, Supplement 1 (November 5, 2020): 15. http://dx.doi.org/10.1182/blood-2020-138548.
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Introduction: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative treatment for many hematological malignancies and disorders. However, this potential is often impeded by several factors including relapse of the underlying disease, graft-vs-host disease (GVHD) and infectious complications. Specifically, acute GVHD continues to be a major factor in the morbidity and mortality of patients. Hence, the practice of allo-SCT is continuously evolving to mitigate these factors. In particular, advances in the conditioning regimens, GVHD prophylaxis, infectious disease monitoring and prophylaxis and supportive care not only have resulted in improved outcomes, but also have expanded potential indications for allo-HSCT. Therefore, we conducted a retrospective analysis on patients who underwent allo-SCT at The Ohio State University from 1986-2018 to better understand how survival has changed longitudinally in accordance with these therapeutic advancements. Method: We analyzed data from 1943 consecutive patients who received an allo-SCT. Patients were divided into seven groups based on the year of transplant: groups (gp) 1: 1984-1988, 2: 1989-1993, 3: 1994-1998, 4: 1999-2003, 5: 2004-2008, 6: 2009-2013, and 7: 2014-2018. The primary endpoints were overall survival (OS) and progression free survival (PFS), and log-rank test was used to compare across transplant years. The Kaplan-Meier method was used to estimate OS and PFS. The secondary endpoints were the cumulative incidences of grade II-IV and grade III-IV acute GVHD (aGVHD), chronic GVHD (cGVHD), and non-relapse mortality (NRM). Cumulative incidence rates were estimated and compared using Gray's test accounting for competing risks. Results: Across the years (1984-2018), the median age was 50.0 (range: 18-76) with 59.6% of the patients being male. Acute myeloid leukemia accounted for 36.3% of transplants, followed by non-Hodgkin lymphoma (14.2%), acute lymphoid leukemia (11.8%), chronic myeloid leukemia (10.1%), and myelodysplastic syndrome (10.0%). Fifty-five percent of patients received myeloablative conditioning. Across the groups, statistically significant improvements in PFS and OS were observed (p<0.001 and p<0.001, respectively) (Figure 1a, 1b). The median PFS improved from 0.8 yrs. (95% confidence interval [CI]: 0.6-1.2) in gp 1 to 3.7 yrs. (95% CI: 2.3-NR) in gp 7. The median OS also improved from 1.0 yrs. (95% CI: 0.7-1.2) in gp1 to NR (95% CI: 4.2-NR) in gp7. The 5-yr PFS among the groups were 24, 25, 25, 28, 33, 41 and 48%, respectively, with a significant improvement seen since 2004. Similar improved trends were seen at 10 yrs. The 5-yr OS were 25, 28, 28, 28, 40, 47 and 53%, respectively, with similar significant improvement seen since 2004. Similar improved trends were seen at 10 yrs. Complete GVHD data was available since 1999 (gp 4-7). The cumulative incidence of grade II-IV aGVHD increased over the years: 36, 27, 38, and 52% at day 100 and 37, 31, 44, and 55%, respectively, at day 180 (Figure 1c). Grade III-IV aGVHD were 21, 10, 11, and 19% at day 100 and 22, 11, 13, and 21% by day 180, respectively, with the highest rate seen for groups 4 and 7. Overall cGVHD also increased over the 4 group years with day 365 cGVHD at 38, 40, 34, and 48% and extensive cGVHD at 27, 34, 31, and 44%, respectively (p<0.001 and p<0.001, respectively). The rate of NRM significantly improved across the years, with 1-yr NRM at 40, 38, 42, 46, 21, 15, and 15% and 5-yr NRM at 54, 51, 51, 57, 31, 22, and 24%, respectively, with a significant improvement seen since 2004 (Figure 1d). Conclusion: Our data shows improved overall and progression-free survival post allo-SCT over decades, which may be attributed to advances in supportive care, and GVHD and relapse mitigation therapy. The decline in NRM is also likely due to improved supportive measures such as infectious disease monitoring and prophylaxis. Nonetheless, post-transplant relapse and grade III-IV aGVHD remain prominent challenges. Therefore, future research should continue to investigate therapeutic strategies that can both reduce high grade GVHD while limiting post-transplant relapse. Disclosures Chaudhry: Sanofi: Consultancy, Membership on an entity's Board of Directors or advisory committees. Bumma:Amgen: Speakers Bureau; Sanofi: Speakers Bureau. Khan:Amgen: Consultancy; Janssen: Consultancy. Devarakonda:Janssen: Consultancy. Vasu:Kiadis Inc: Other: Kiadis has obtained exclusive licensing requirements from The OHio State University; Janssen: Membership on an entity's Board of Directors or advisory committees; Omeros: Membership on an entity's Board of Directors or advisory committees. Jaglowski:CRISPR: Consultancy; Novartis: Consultancy, Research Funding; Juno: Consultancy; Kite, a Gilead Company: Consultancy, Research Funding. William:Incyte: Research Funding; Guidepoint Global: Consultancy; Dova: Research Funding; Merck: Research Funding; Seattle Genetics: Research Funding; Kyowa Kirin: Consultancy, Honoraria; Celgene: Consultancy, Honoraria. Mims:Leukemia and Lymphoma Society: Other: Senior Medical Director for Beat AML Study; Agios: Consultancy; Abbvie: Membership on an entity's Board of Directors or advisory committees; Syndax Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Jazz Pharmaceuticals: Other: Data Safety Monitoring Board; Kura Oncology: Membership on an entity's Board of Directors or advisory committees; Novartis: Speakers Bureau. Brammer:Bristol-Myers Squibb: Research Funding; Celgene: Research Funding; Seattle Genetics: Honoraria, Speakers Bureau; Kymera: Honoraria; Verastem Oncology: Other: Travel. Saad:Incyte Pharmaceuticals: Other: Personal Fees; Amgen: Other: research support; Kadmon: Other: research support; Orcabio: Other: research support; Magenta Therapeutics: Other: Personal Fees. Efebera:Celgene: Research Funding; Takeda: Honoraria, Speakers Bureau; Pharmacyclics: Research Funding; Ohio State University: Current Employment.
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Leggett, Amanda N., Benjamin C. Bugajski, Laura N. Gitlin, and Helen C. Kales. "Characterizing dementia caregiver style in managing care challenges: Cognitive and behavioral components." Dementia 20, no. 6 (January 31, 2021): 2188–204. http://dx.doi.org/10.1177/1471301220988233.
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Background Caring for a person living with dementia can take a physical and emotional toll, but understudied is the process by which family caregivers actually provide care. Caregiver management styles may vary and affect care decision-making, experiences, receptivity to and participation in interventions, and outcomes for the caregiver and person living with dementia. Methods Participants included 100 primary family caregivers for persons with dementia who were on average 64 years old and had been providing care for 55 months, 74% women, and 18% nonwhite. Participants were interviewed in Michigan and Ohio regarding their cognitive and behavioral management of a recent care challenge and values guiding their decision-making. The rigorous and accelerated data reduction technique was used to analyze qualitative data leading to the identification of caregiving styles. Styles were compared across sample characteristics using chi-square and ANOVA tests. Findings Five distinct styles emerged: “Externalizers” (superficial understanding, self-focused, and frequent expressions of anger or frustration), “Individualists” (provide care by going alone, emotionally removed, and lack management strategies), “Learners” (recognize need to change their approach but are stuck and emotionally turbulent), “Nurturers” (positive affect and empathy toward care and reflect natural mastery), and “Adapters” (arsenal of acquired management strategies and adapt to challenges). Style groups differed significantly in terms of age and use of formal care supports. Discussion We identified five distinct styles by which caregivers addressed care challenges using a robust qualitative methodology. Styles may be important to identify in order to better tailor interventions to needs and abilities.
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Parikh, Ankur, Meredith Spitz, Cooper T. Johnson, and S. A. Erzurum. "Sight for All United: Five Year Impact of a Vision Foundation on its Community." Ohio Journal of Public Health 4, no. 1 (June 21, 2021): 60–66. http://dx.doi.org/10.18061/ojph.v4i1.8074.
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Background: In 2016, Sight for All United (SFAU) was founded in the Mahoning Valley of Ohio with the mission of improving access to care and maximizing the visual potential of the underserved. Methods: A retrospective chart review was conducted on patients served by SFAU from January 2016 through August 2020. Socioeconomic information, type of service, cost, and dollar amount paid were collected for patients. The data were analyzed with descriptive statistics and mapped with Esri ArcGIS. Results: A total of 1327 patients received assistance through the medical assistance and school vision programs. In the medical assistance program, 222 patients (mean age 50 years, 57% female) completed applications and 37% (83 patients) were in a household of 3 or more people. Median yearly income was $18 504, 134% above the federal poverty level by household size. The most common surgical services were cataract surgery (101) and vitreoretinal care (17). The most common medical services were eye exams (79) and spectacles (76). Estimated value of medical services provided was $367 249; actual cost was $93 746. The school vision program provided 1105 eye exams, 1514 pairs of spectacles, and 1 cataract surgery with an estimated value of $133 692. Conclusion: Sight for All United provided $500 941 of vision services to its patients since 2016 while dispersing less than $100 000 of donated dollars through collaboration with eye care providers, community resources, and national foun-dations. This study demonstrates the impact vision foundations managed by local eye care providers can have on the needs in their community in a cost-effective and efficient way.
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Miller, Gay Y., Paul C. Bartlett, Susan E. Lance, Judy Anderson, and Lawrence E. Heider. "Costs of clinical mastitis and mastitis prevention in dairy herds." Journal of the American Veterinary Medical Association 202, no. 8 (April 15, 1993): 1230–36. http://dx.doi.org/10.2460/javma.1993.202.08.1230.
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Summary: A stratified random sample of 50 Ohio dairy herds, monitored for 1 year between March 1988 and May 1989, was used to estimate the component costs of clinical mastitis per cow-year overall and by organism, the component costs of an episode of clinical mastitis overall and by organism, and the incidence of clinical mastitis by organism. Each herd was visited monthly by a veterinarian who conducted on-farm interviews and completed standardized data-collection forms designed to elicit economic information about the on-farm costs of clinical mastitis and mastitis prevention. Producers collected milk samples prior to treatment of clinical mastitis cases. Culturing methods allowed identification of 18 specific mastitis pathogen classifications. Annual costs estimated were on a per cow-year and clinical episode basis. The monthly mean population of cows monitored was 4,068. Mastitis prevention cost $14.50/cow-year, whereas the cost incurred by producers because of clinical cases of mastitis was $37.91. Organisms prevalent in the cows’ environment caused the most costly types of mastitis. Disregarding contaminated samples and episodes for which no milk samples were taken, mastitis for which 2 organisms were isolated accounted for 35.5% of costs of clinical mastitis, followed by cases for which Escherichia coli (21.3%) was isolated, cases for which culturing yielded no growth (8.6%), and cases for which esculin-positive Streptococcus spp (6.4%), Klebsiella spp (5.7%), esculin-negative CAMP-negative Streptococcus spp (5.1%), Enterobacter spp (4.8%), coagulase-negative Staphylococcus spp (4.1%), coagulase-positive Staphylococcus spp (3.0%), S agalactiae (2.5%), and Bacillus spp (1.2%) were isolated. Other categories of classification each accounted for < 0.5% of costs. Mean cost per clinical episode was $107.11. Mean incidence of clinical mastitis was 38.74 cases/100 cowyears. Mixed infections had the highest incidence (mean, 4.80 cases/100 cow-years), followed by cases with no growth (2.96), E coli (2.10), esculin-positive Streptococcus spp (1.94), coagulase-negative Staphylococcus spp (1.60), esculin-negative CAMP-negative Streptococcus spp (1.25), coagulase-positive Staphylococcus spp (1.04), Enterobacter spp (0.36), and Klebsiella spp (0.27).
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Crowe, Remle P., Roger Levine, Severo Rodriguez, Ashley D. Larrimore, and Ronald G. Pirrallo. "Public Perception of Emergency Medical Services in the United States." Prehospital and Disaster Medicine 31, S1 (November 25, 2016): S112—S117. http://dx.doi.org/10.1017/s1049023x16001126.
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AbstractObjectiveThe objective of this study was to assess the public’s experience, expectations, and perceptions related to Emergency Medical Services (EMS).MethodsA population-based telephone interview of adults in the United States was conducted. The survey instrument consisted of 112 items. Demographic variables including age, race, political beliefs, and household income were collected. Data collection was performed by trained interviewers from Kent State University’s (Kent, Ohio USA)Social Research Laboratory. Descriptive statistics were calculated. Comparative analyses were conducted between those who used EMS at least once in the past five years and those who did not use EMS using χ2andttests.ResultsA total of 2,443 phone calls were made and 1,348 individuals agreed to complete the survey (55.2%). There were 297 individuals who requested to drop out of the survey during the phone interview, leaving a total of 1,051 (43.0%) full responses. Participants ranged in age from 18 to 94 years with an average age of 57.5 years. Most were Caucasian or white (83.0%), married (62.8%), and held conservative political beliefs (54.8%). Three-fourths of all respondents believed that at least 40% of patients survive cardiac arrest when EMS services are received. Over half (56.7%) believed that Emergency Medical Technician (EMT)-Basics and EMT-Paramedics provide the same level of care. The estimated median hours of training required for EMT-Basics was 100 hours (IQR: 40-200 hours), while the vast majority of respondents estimated that EMT-Paramedics are required to take fewer than 1,000 clock hours of training (99.3%). The majority believed EMS professionals should be screened for illegal drug use (97.0%), criminal background (95.9%), mental health (95.2%), and physical fitness (91.3%). Over one-third (37.6%) had used EMS within the past five years. Of these individuals, over two-thirds (69.6%) rated their most recent experience as “excellent.” More of those who used EMS at least once in the past five years reported a willingness to consent to participate in EMS research compared with those who had not used EMS (69.9% vs. 61.4%,P=.005).ConclusionsMost respondents who had used EMS services rated their experience as excellent. Nevertheless, expectations related to survival after cardiac arrest in the out-of-hospital setting were not realistic. Furthermore, much of the public was unaware of the differences in training hour requirements and level of care provided by EMT-Basics and EMT-Paramedics.CroweRP,LevineR,RodriguezS,LarrimoreAD,PirralloRG.Public perception of Emergency Medical Services in the United States.Prehosp Disaster Med.2016;31(Suppl.1):s112–s117.
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Eyles, Nicholas, Carolyn H. Eyles, Christopher Woodworth-Lynas, and Todd A. Randall. "The sedimentary record of drifting ice (early Wisconsin Sunnybrook deposit) in an ancestral ice-dammed Lake Ontario, Canada." Quaternary Research 63, no. 2 (March 2005): 171–81. http://dx.doi.org/10.1016/j.yqres.2004.12.002.
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Outcrops of pebbly mud (diamict) at Scarborough in Southern Ontario, Canada (the so-called Sunnybrook ‘Till’) are associated with the earliest incursion of the Laurentide Ice Sheet (LIS) into mid-continent North America some 45,000 years ago. The Sunnybrook is a blanket-like deposit containing deepwater ostracodes and occurs conformably within a thick (100 m) succession of deltaic and glaciolacustrine facies that record water depth changes in a large proglacial lake. Contextual evidence (associated facies, sedimentary structures, deposit geometry and landforms) indicates a low energy depositional setting in an ice-dammed ancestral Lake Ontario in which scouring by floating ice masses was an important process. U-shaped, iceberg-cut scours (with lateral berms) up to 7 m deep, occur on the upper surface of the Sunnybrook and are underlain by ‘sub-scour’ structures that extend several meters below the scour base. Ice-rafted concentrations of clasts (‘clast layers’), grooved surfaces formed by floating ice glissading over a muddy lake floor (‘soft sediment striations’) and melanges of sand and mud mixed by grounding ice keels (‘ice keel turbates’) are present and are all well known from modern cold environments. The wider significance of this depositional model is that the LIS margin lay east of Scarborough and did not overrun Southern Ontario. This finding is in agreement with recent data from the Erie Basin of Canada, Ohio, and Indiana where deposits formerly correlated with the Sunnybrook (and thus implying an extensive early Wisconsin ice sheet) are now regarded as Illinoian. A speculative hypothesis is proposed that relates deposition of the Sunnybrook and two younger deposits of similar sedimentology, to surge-like instabilities of the southern LIS margin.
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Nita, M., M. A. Ellis, L. L. Wilson, and L. V. Madden. "Evaluation of a Disease Warning System for Phomopsis Cane and Leaf Spot of Grape: A Field Study." Plant Disease 90, no. 9 (September 2006): 1239–46. http://dx.doi.org/10.1094/pd-90-1239.
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A field evaluation of a warning system for Phomopsis cane and leaf spot of grape (Vitis spp.), caused by Phomopsis viticola, was conducted in Ohio over 3 years (2002 to 2004) by applying fungicides and fungicide-adjuvant combinations based on predicted infection events. Three different criteria for risk—light, moderate, and high—were evaluated with the warning system. The warning system is based on measured weather conditions (temperature and wetness duration following rain) and a model for risk of leaf and internode infection. Vines were sprayed with fungicides based on either the warning system or a calendar-based 7-day protectant program, from 2.5-cm shoot growth (Eichhorn-Lorenz [E-L] stage 7) to the end of the broom (E-L stage 27). Fungicides were tested with or without an adjuvant (JMS Stylet-Oil or Regulaid). In the controls, the mean percentage of leaves and internodes with infections ranged from 36 to 100%, the number of lesions per leaf ranged from 1 to 28, and percentage of internodes covered by lesions ranged from 1 to 12%. Both the calendar-based protectant treatment (based on use of mancozeb) and the warning system treatment based on spraying in response to light or moderate predicted infection events (especially with mancozeb + Regulaid) resulted in significantly less disease incidence and severity compared with the controls. The mean percent control (relative difference in disease between a treatment and the control) was higher for the protectant schedule (˜55% and ˜80% for incidence and severity, respectively, based on application of mancozeb) than for the warning system (˜36% and ˜60% for incidence and severity, respectively, based on application of mancozeb + Regulaid), but there were two to three times more fungicide applications with the protectant schedule than with the warning system.
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Kegler, Michelle C., Regine Haardörfer, Taylor Melanson, Lindsey Allen, Lucja T. Bundy, Matthew W. Kreuter, Rebecca S. Williams, Melbourne F. Hovell, and Patricia Dolan Mullen. "Steps Toward Scalability: Illustrations From a Smoke-Free Homes Program." Health Education & Behavior 46, no. 5 (June 5, 2019): 773–81. http://dx.doi.org/10.1177/1090198119848767.
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Scalable interventions remain effective across a range of real-world settings and can be modified to fit organizational and community context. “Smoke-Free Homes: Some Things are Better Outside” has been effective in promoting smoke-free home rules in low-income households in efficacy, effectiveness, generalizability, and dissemination studies. Using data from a dissemination study in collaboration with five 2-1-1 call centers in Ohio, Florida, Oklahoma, and Alabama ( n = 2,345 households), this article examines key dimensions of scalability, including effectiveness by subpopulation, secondary outcomes, identification of core elements driving effectiveness, and cost-effectiveness. Evaluated by 2-1-1 staff using a pre–post design with self-reported outcomes at 2 months postbaseline, the program was equally effective for men and women, across education levels, with varying number of smokers in the home, and whether children were present in the home or not. It was more effective for nonsmokers, those who smoked fewer cigarettes per day, and African Americans. Creating a smoke-free home was associated with a new smoke-free vehicle rule (odds ratio [OR] = 3.38, confidence interval [CI 2.58, 4.42]), decreased exposure to secondhand smoke among nonsmokers (b = −2.33, p < .0001), and increased cessation among smokers (OR = 5.8, CI [3.81, 8.81]). Use of each program component was significantly associated with success in creating a smoke-free home. Using an intent-to-treat effect size of 40.1%, program benefits from 5 years of health care savings exceed program costs yielding a net savings of $9,633 for delivery to 100 households. Cost effectiveness, subpopulation analyses, and identification of core elements can help in assessing the scalability potential of research-tested interventions such as this smoke-free homes program.
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Shrestha, Nabin K., Patrick C. Burke, Amy S. Nowacki, and Steven M. Gordon. "Risk of Coronavirus Disease 2019 (COVID-19) among those up-to-date and not up-to-date on COVID-19 vaccination by US CDC criteria." PLOS ONE 18, no. 11 (November 8, 2023): e0293449. http://dx.doi.org/10.1371/journal.pone.0293449.
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Background The CDC recently defined being “up-to-date” on COVID-19 vaccination as having received at least one dose of a COVID-19 bivalent vaccine. The purpose of this study was to compare the risk of COVID-19 among those “up-to-date” and “not up-to-date”. Methods Employees of Cleveland Clinic in Ohio, USA, in employment when the COVID-19 bivalent vaccine first became available, and still employed when the XBB lineages became dominant, were included. Cumulative incidence of COVID-19 since the XBB lineages became dominant was compared across the”up-to-date” and “not up-to-date” states, by treating COVID-19 bivalent vaccination as a time-dependent covariate whose value changed on receipt of the vaccine. Risk of COVID-19 by vaccination status was also evaluated using multivariable Cox proportional hazards regression adjusting for propensity to get tested for COVID-19, age, sex, most recent prior SARS-CoV-2 infection, and number of prior vaccine doses. Results COVID-19 occurred in 1475 (3%) of 48 344 employees during the 100-day study period. The cumulative incidence of COVID-19 was lower in the “not up-to-date” than the “up-to-date” state. On multivariable analysis, being “up-to-date” was not associated with lower risk of COVID-19 (HR, 1.05; 95% C.I., 0.88–1.25; P-value, 0.58). Results were very similar when those 65 years and older were only considered “up-to-date” after 2 doses of the bivalent vaccine. Conclusions Since the XBB lineages became dominant, adults “up-to-date” on COVID-19 vaccination by the CDC definition do not have a lower risk of COVID-19 than those “not up-to-date”, bringing into question the value of this risk classification definition.
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Dally, Diana L., Wendy Dahar, Ann Scott, Douglas Roblin, and Allan T. Khoury. "The Impact of a Health Education Program Targeting Patients with High Visit Rates in a Managed Care Organization." American Journal of Health Promotion 17, no. 2 (November 2002): 101–11. http://dx.doi.org/10.4278/0890-1171-17.2.101.
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Purpose. To determine if a mailed health promotion program reduced outpatient visits while improving health status. Design. Randomized controlled trial. Setting. A midsized, group practice model, managed care organization in Ohio. Subjects. Members invited (N = 3214) were high utilizers, 18 to 64 years old, with hypertension, diabetes, or arthritis (or all). A total of 886 members agreed to participate, and 593 members returned the initial questionnaires. The 593 members were randomized to the following groups: 99 into arthritis treatment and 100 into arthritis control, 94 into blood pressure treatment and 92 into blood pressure control, and 104 into diabetes treatment and 104 into diabetes control. Measures. Outpatient utilization, health status, and self-efficacy were followed over 30 months. Interventions. Health risk appraisal questionnaires were mailed to treatment and control groups before randomization and at 1 year. The treatment group received three additional condition-specific (arthritis, diabetes, or hypertension) questionnaires and a health information handbook. The treatment group also received written health education materials and an individualized feedback letter after each returned questionnaire. The control group received condition-specific written health education materials and reimbursement for exercise equipment or fitness club membership after returning the 1-year end of the study questionnaire. Results. Changes in visit rates were disease specific. Parameter estimates were calculated from a Poisson regression model. For intervention vs. controls, the arthritis group decreased visits 4.84 per 30 months (p < 0.00), the diabetes group had no significant change, and the hypertension group increased visits 2.89 per 30 months (p < 0.05), the overall health status improved significantly (−6.5 vs. 2.3, p < 0.01) for the arthritis group but showed no significant change for the other two groups, and coronary artery disease and cancer risk scores did not change significantly for any group individually. Overall self-efficacy for intervention group completers improved by −8.6 points (p < 0.03) for the arthritis group, and the other groups showed no significant change. Conclusions. This study demonstrated that in a population of 18 to 64 years with chronic conditions, mailed health promotion programs might only benefit people with certain conditions.
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Pratt, Thomas L., James F. Dolan, Jackson K. Odum, William J. Stephenson, Robert A. Williams, and Mary E. Templeton. "Multiscale seismic imaging of active fault zones for hazard assessment: A case study of the Santa Monica fault zone, Los Angeles, California." GEOPHYSICS 63, no. 2 (March 1998): 479–89. http://dx.doi.org/10.1190/1.1444349.
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High‐resolution seismic reflection profiles at two different scales were acquired across the transpressional Santa Monica Fault of north Los Angeles as part of an integrated hazard assessment of the fault. The seismic data confirm the location of the fault and related shallow faulting seen in a trench to deeper structures known from regional studies. The trench shows a series of near‐vertical strike‐slip faults beneath a topographic scarp inferred to be caused by thrusting on the Santa Monica fault. Analysis of the disruption of soil horizons in the trench indicates multiple earthquakes have occurred on these strike‐slip faults within the past 50 000 years, with the latest being 1000 to 3000 years ago. A 3.8-km-long, high‐resolution seismic reflection profile shows reflector truncations that constrain the shallow portion of the Santa Monica Fault (upper 300 m) to dip northward between 30° and 55°, most likely 30° to 35°, in contrast to the 60° to 70° dip interpreted for the deeper portion of the fault. Prominent, nearly continuous reflectors on the profile are interpreted to be the erosional unconformity between the 1.2 Ma and older Pico Formation and the base of alluvial fan deposits. The unconformity lies at depths of 30–60 m north of the fault and 110–130 m south of the fault, with about 100 m of vertical displacement (180 m of dip‐slip motion on a 30°–35° dipping fault) across the fault since deposition of the upper Pico Formation. The continuity of the uncomformity on the seismic profile constrains the fault to lie in a relatively narrow (50 m) zone, and to project to the surface beneath Ohio Avenue immediately south of the trench. A very high‐resolution seismic profile adjacent to the trench images reflectors in the 15 to 60 m depth range that are arched slightly by folding just north of the fault. A disrupted zone on the profile beneath the south end of the trench is interpreted as being caused by the deeper portions of the trenched strike‐slip faults where they merge with the thrust fault.
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Koroukian, Siran M., Jennifer Tsui, Weichuan Dong, Xiaoyu Yan, Uriel Kim, Johnie Rose, Jeffrey Albert, Kristine M. Zanotti, Cynthia Owusu, and Gregory Cooper. "Towards reducing cancer burden within the Medicaid program: Impact of Medicaid expansion on cancer stage at diagnosis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 1572. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1572.
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1572 Background: Studies to date have shown post-Medicaid expansion (M-exp) decreases in the percentage of cancer patients who are uninsured and improvements in cancer stage at diagnosis in states that expanded Medicaid as part of the Affordable Care Act. However, most studies have examined impact of M-exp on stage outcomes at the population level, or among Medicaid and uninsured, rather than solely in the Medicaid population. Using cancer registry data from a non M-exp state (Georgia (GA)) and two M-exp states (Ohio (OH) and New Jersey (NJ)), we compared changes in cancer stage in patients on Medicaid, accounting for individual- and contextual-level characteristics at the Zip Code Tabulation Area (ZCTA) level. Methods: We used GA, OH, and NJ cancer registry data for individuals 20-64 years of age and diagnosed with incident invasive female breast (BC), cervical (CC), and colorectal cancer (CRC). Data spanned from 2010-2017 for GA and OH, and from 2011-2016 for NJ (for BC and CRC only), with 2014 marking the year in which Medicaid was expanded in OH and NJ. We retrieved demographic data (age, race/ethnicity, sex for CRC, insurance status, and cancer stage from the cancer registries), and obtained ZCTA-level data from the American Community Survey (e.g., income, education, and female-headed households). We defined late-stage diagnosis as regional- or distant- stage. We conducted multivariable logistic regression models by state and cancer site to examine changes in late-stage cancer diagnosis pre- and post-M-exp, accounting for individual- and ZCTA-level covariates. Results: The number of patients with incident cancer who were on Medicaid increased by 41.7% (n = 1757 to 2490), 59.6% (327 to 522), and 76.4% (953 to 1681) for BC, CC, and CRC cancers, respectively, in Ohio; by 92.4% (433 to 833) for BC and by over 100% for CRC (232 to 496) in NJ; but by 12.7% (662 to 746) among CRC patients in GA, where the number of BC and CC patients on Medicaid remained relatively stable. Adjusting for individual and contextual-level factors, the adjusted risk ratio (ARR and (95% Confidence Interval)) for late-stage disease was lowest for BC patients in OH (0.93 (0.87, 0.99)) and for CRC patients in GA (0.94 (0.89, 0.99)). The ARR for BC and CRC in NJ were not statistically significant, though they trended towards improvement. Similarly, changes in late-stage for CC were not statistically significant in OH or in GA. Conclusions: The increased number of cancer patients in Medicaid and the reductions in late-stage diagnosis observed may potentially translate into reduced, or at least stabilized, cancer-related morbidity and mortality burden among Medicaid beneficiaries over time. However, reductions in late-stage diagnosis were not consistent across cancer sites or states, possibly due to differences in population demographics, health behaviors, healthcare seeking patterns, and state-level cancer prevention efforts.
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Stopka, Thomas J., Denise C. Babineau, Erin B. Gibson, Charles E. Knott, Debbie M. Cheng, Jennifer Villani, Jonathan M. Wai, et al. "Impact of the Communities That HEAL Intervention on Buprenorphine-Waivered Practitioners and Buprenorphine Prescribing." JAMA Network Open 7, no. 2 (February 22, 2024): e240132. http://dx.doi.org/10.1001/jamanetworkopen.2024.0132.
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ImportanceBuprenorphine significantly reduces opioid-related overdose mortality. From 2002 to 2022, the Drug Addiction Treatment Act of 2000 (DATA 2000) required qualified practitioners to receive a waiver from the Drug Enforcement Agency to prescribe buprenorphine for treatment of opioid use disorder. During this period, waiver uptake among practitioners was modest; subsequent changes need to be examined.ObjectiveTo determine whether the Communities That HEAL (CTH) intervention increased the rate of practitioners with DATA 2000 waivers and buprenorphine prescribing.Design, Setting, and ParticipantsThis prespecified secondary analysis of the HEALing Communities Study, a multisite, 2-arm, parallel, community-level, cluster randomized, open, wait-list–controlled comparison clinical trial was designed to assess the effectiveness of the CTH intervention and was conducted between January 1, 2020, to December 31, 2023, in 67 communities in Kentucky, Massachusetts, New York, and Ohio, accounting for approximately 8.2 million adults. The participants in this trial were communities consisting of counties (n = 48) and municipalities (n = 19). Trial arm randomization was conducted using a covariate constrained randomization procedure stratified by state. Each state was balanced by community characteristics including urban/rural classification, fatal opioid overdose rate, and community population. Thirty-four communities were randomized to the intervention and 33 to wait-list control arms. Data analysis was conducted between March 20 and September 29, 2023, with a focus on the comparison period from July 1, 2021, to June 30, 2022.InterventionWaiver trainings and other educational trainings were offered or supported by the HEALing Communities Study research sites in each state to help build practitioner capacity.Main Outcomes and MeasuresThe rate of practitioners with a DATA 2000 waiver (overall, and stratified by 30-, 100-, and 275-patient limits) per 100 000 adult residents aged 18 years or older during July 1, 2021, to June 30, 2022, were compared between the intervention and wait-list control communities. The rate of buprenorphine prescribing among those waivered practitioners was also compared between the intervention and wait-list control communities. Intention-to-treat and per-protocol analyses were performed.ResultsA total of 8 166 963 individuals aged 18 years or older were residents of the 67 communities studied. There was no evidence of an effect of the CTH intervention on the adjusted rate of practitioners with a DATA 2000 waiver (adjusted relative rate [ARR], 1.04; 95% CI, 0.94-1.14) or the adjusted rate of practitioners with a DATA 2000 waiver who actively prescribed buprenorphine (ARR, 0.97; 95% CI, 0.86-1.10).Conclusions and RelevanceIn this randomized clinical trial, the CTH intervention was not associated with increases in the rate of practitioners with a DATA 2000 waiver or buprenorphine prescribing among those waivered practitioners. Supporting practitioners to prescribe buprenorphine remains a critical yet challenging step in the continuum of care to treat opioid use disorder.Trial RegistrationClinicalTrials.gov Identifier: NCT04111939
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Habib, Joyce, Neil Dunavin, Gary Phillips, Patrick Elder, Meaghan Tranovich, Don M. Benson, Craig C. Hofmeister, John C. Byrd, Steven M. Devine, and Yvonne Efebera. "Analysis of 179 Patients with Newly Diagnosed Multiple Myeloma (MM) Treated with Novel Agents Followed by Autologous Stem Cell Transplantation (ASCT): a Retrospective Study." Blood 116, no. 21 (November 19, 2010): 1343. http://dx.doi.org/10.1182/blood.v116.21.1343.1343.
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Abstract Abstract 1343 Background: Multiple myeloma (MM) is the second most common hematological malignancy in the United States with an estimated 20,580 new cases in 2009. Over the past decade, the introduction of novel agents (thalidomide, lenalidomide and bortezomib) have played a pivotal role in improving response rates, duration of response, overall survival (OS) and quality of life. In this study we describe a single center experience with novel agents used for induction followed by high dose chemotherapy (HDT) and first autologous stem cell transplant (ASCT) in patients with MM. Method: A retrospective review of the medical records of 179 newly diagnosed patients with MM seen between October 2006 and December 2009 at The Ohio State University was performed. All patients received novel therapy containing thalidomide, bortezomib or lenalidomide as part of an induction regimen followed by ASCT. All patients received melphalan 140mg/m2 or 200mg/m2 as preparative regimen. Kaplan-Meier estimates were used to plot progression free survival and overall survival. Results: Of the 181 patients seen, 2 were excluded because they did not receive a novel agent as part of induction treatment. Of the 179 patients analyzed, median age was 56.8 years (29-80) with 30% of patients older than 60 years. African American represented 19%. Fifty-nine percent were male, 80% had Durie-Salmon (DS) stage III while 25%, 28%, 18% represented International prognostic score (IPS) stage I, II, and III respectively with 27% unknown. Median comorbidity index score was 2 (2-7) and median Karnofsky performance score (KPS) was 90% (70-100). Thirty percent had high risk genetic profile, and 73% received one line of treatment before ASCT. The median time from diagnosis to ASCT was 8.33 months (4-58). The overall response rate (ORR) prior to transplant was 84% (9% complete (CR), 29% very good partial (VGPR), and 46% partial (PR)). The ORR post ASCT was 89% (CR 45%, VGPR 22%, PR 21%). Non relapse mortality was 1% and 3% at 100 days and 1 year respectively. At a median follow up of 31 months (7-90), 69 patients (38%) had relapsed. Median progression free survival (PFS) was 29 months with 1 and 3 years PFS of 79.3% and 61.5% respectively (Fig. 1). The OS was not reached. One and 3 years OS were 93% and 88% respectively (Fig. 1). Univariate analysis showed that time to transplant > 12 months was associated with poor outcome and decreased overall survival (HR 3.30, p = 0.008). High risk genetic profile was also found to be associated with decreased overall survival although this was not statistically significant (HR 2.31, p = 0.070). Multivariate analysis found that only time to transplant > 12 months was an independent predictor of decreased OS. Significant predictors for disease progression were high risk genetic profile and time to transplant > 12 months in patients receiving 2 or more treatments before ASCT. Conclusion: Induction with novel agents followed by HDT and ASCT improves CR rate, in our case from 9% to 45%. Median PFS (29 months) was comparable to other published data. OS was not been reached after a median follow up of 31 months. Predictors of progression include high risk genetic profile and time to transplant > 12 months. The only significant predictor for survival was time to transplant. Our study suggests that an early transplant may improve OS and PFS. An extended analysis will be presented at the meeting. Disclosures: Phillips: NCI/NIH: Research Funding; NCCM Grant: Research Funding; ARRA RC2 Grant: Research Funding. Byrd:Genzyme Corporation: Research Funding.
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Barr, Amy, and Mark Bennett. "Precision Planting for sh2 Sweet Corn Stand Establishment." HortScience 33, no. 3 (June 1998): 535e—536. http://dx.doi.org/10.21273/hortsci.33.3.535e.
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The impact of soil type and planting depths on the emergence of three hybrids of shrunken 2 sweet corn with varying seed vigor was investigated. Two field trials were completed (planted on 18 Sept. 1996 and 6 May 1997) in a field containing Crosby and Kokomo soil types in Columbus, Ohio. Three sh2 hybrids (`Starship', `Skyline', and `Confection') were planted at 1.3-, 2.5-, and 5.1-cm depths with six replications on each of the two soils in the fall study. The same hybrids were planted the following spring with an adjustment to 2-, 4-, and 6-cm planting depths over the same soil types, and the addition of a transition soil. The use of data loggers in 1997 allowed for continual monitoring of soil temperatures at each of the planting depths throughout the field, and calculation of soil heat units throughout the emergence period. There were no significant differences between depths for average temperatures or soil heat units. Minimum temperatures were significantly colder on the lighter color soil and had a linear relationship with emergence counts. Soil tests were carried out at all sites for P, K, Mg, and Ca. Although significant differences were found with the Kokomo soil having higher nutrient levels than the transition or Crosby soil, levels throughout the field were more than adequate for emergence. Compaction and soil moisture measurements were taken with a neutron probe. Dry density was significantly higher on the lighter color soils, while soil moisture percentage climbed from 18% on Crosby to 25% on the Kokomo. In both years, there were significant differences in emergence indices based not only on hybrid and planting depth but also on location. Emergence ranged from below 50% to nearly 100% depending on the treatment and field location. Each of the 108 sampling points was located with a GPS receiver and the use of ArcView software allowed for data layers to be stored and mapped so that prescriptions could be made for best stand establishment.
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Elabd, Hatem, Anjuli Eagleston, Dominique Brandt, and Stephen Blatt. "267. Characteristics and Trends of Serratia Blood Stream Infections." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S133—S134. http://dx.doi.org/10.1093/ofid/ofaa439.311.
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Abstract Background Serratia is an opportunistic pathogen known to cause an array of infectious presentations including UTIs, pneumonia, wound infections, skin and soft tissue infections, surgical site infections and although rare, endocarditis and bacteremia. The aim of the proposed study is to identify the characteristics of patients with community-acquired Serratia blood stream infection over a five-year period within the TriHealth inpatient population within the Cincinnati, Ohio Region. The study will also examine antibiotic resistance patterns among patients with Serratia bloodstream infections. Methods This is a retrospective cohort study of 107 adult patients admitted to two community hospitals from January 2014 to December 2018 with a positive blood culture for Serratia species. A complete data set of 100 patients was analyzed for complications, antibiotic resistance, in-hospital mortality, 90-day mortality, readmission within 90 days and length of Hospital Stay (LOS). Descriptive statistics was performed using frequencies for discrete variables and median (IQR) for continuous variables. Results Patients admitted with a positive Serratia blood culture were 38% female with a median (IQR) age of 54.5 years (40.25–71.75) and predominantly white (85%). Forty percent had hepatitis C (HCV) infection and 42% had a history of IV drug use. Most patients were living at home (77%), 18% in long term care and 91% were infected with Serratia marcescens. The most common complications were endocarditis (12%) and osteomyelitis (10%). Extended spectrum beta-lactamase (ESBL) production was confirmed in 13%. In-hospital mortality was 2%, 90-day mortality 2%, readmission 23% and median (IQR) LOS 7(3.25–14.75). PATIENT CHARACTERISTICS AND OUTCOMES (part 1) PATIENT CHARACTERISTICS AND OUTCOMES (part 2) PATIENT CHARACTERISTICS AND OUTCOMES (part 3) Conclusion This study demonstrates that a high proportion of patients admitted with Serratia bacteremia are IV drugs users and that they have a high prevalence of coexistent HCV infection. Endocarditis and metastatic foci of infection are relatively common. Appropriate empiric antibiotic management should take into account the significant incidence of ESBL production resulting in a prolonged LOS and a high readmission rate. Disclosures All Authors: No reported disclosures
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Kasson, M. T., D. P. G. Short, E. S. O'Neal, K. V. Subbarao, and D. D. Davis. "Comparative Pathogenicity, Biocontrol Efficacy, and Multilocus Sequence Typing of Verticillium nonalfalfae from the Invasive Ailanthus altissima and Other Hosts." Phytopathology® 104, no. 3 (March 2014): 282–92. http://dx.doi.org/10.1094/phyto-06-13-0148-r.
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Verticillium wilt, caused by Verticillium nonalfalfae, is currently killing tens of thousands of highly invasive Ailanthus altissima trees within the forests in Pennsylvania, Ohio, and Virginia and is being considered as a biological control agent of Ailanthus. However, little is known about the pathogenicity and virulence of V. nonalfalfae isolates from other hosts on Ailanthus, or the genetic diversity among V. nonalfalfae from confirmed Ailanthus wilt epicenters and from locations and hosts not associated with Ailanthus wilt. Here, we compared the pathogenicity and virulence of several V. nonalfalfae and V. alfalfae isolates, evaluated the efficacy of the virulent V. nonalfalfae isolate VnAa140 as a biocontrol agent of Ailanthus in Pennsylvania, and performed multilocus sequence typing of V. nonalfalfae and V. alfalfae. Inoculations of seven V. nonalfalfae and V. alfalfae isolates from six plant hosts on healthy Ailanthus seedlings revealed that V. nonalfalfae isolates from hosts other than Ailanthus were not pathogenic on Ailanthus. In the field, 100 canopy Ailanthus trees were inoculated across 12 stands with VnAa140 from 2006 to 2009. By 2011, natural spread of the fungus had resulted in the mortality of >14,000 additional canopy Ailanthus trees, 10,000 to 15,000 Ailanthus sprouts, and nearly complete eradication of Ailanthus from several smaller inoculated stands, with the exception of a few scattered vegetative sprouts that persisted in the understory for several years before succumbing. All V. nonalfalfae isolates associated with the lethal wilt of Ailanthus, along with 18 additional isolates from 10 hosts, shared the same multilocus sequence type (MLST), MLST 1, whereas three V. nonalfalfae isolates from kiwifruit shared a second sequence type, MLST 2. All V. alfalfae isolates included in the study shared the same MLST and included the first example of V. alfalfae infecting a non-lucerne host. Our results indicate that V. nonalfalfae is host adapted and highly efficacious against Ailanthus and, thus, is a strong candidate for use as a biocontrol agent.
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Rodriguez Berrios, Maria D., Amy LeClair, Janis Breeze, Sarah Reisenger, Evelyn Gonzalez, Jill Oliveri, Electra Paskett, and Karen Freund. "3262 Determining the association of acculturation, community identity and discrimination on cancer screening rates and quality of life among underserved populations." Journal of Clinical and Translational Science 3, s1 (March 2019): 142. http://dx.doi.org/10.1017/cts.2019.322.
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OBJECTIVES/SPECIFIC AIMS: To determine the association of participant’s characteristics and socio-cultural factors including acculturation, community identity and discrimination with the adherence to cancer screening guidelines and participants’ quality of life. METHODS/STUDY POPULATION: As part of the Cancer Disparities Research Network pilot cohort, the study recruited 333 participants across four sites: Boston Chinatown, African American communities in Philadelphia, and Hispanic communities in Columbus, and rural white communities in Appalachia, Ohio. Enrolled participants were eligible if they were 40 to 74 years old, did not live in a nursing home or other facility, and had no prior invasive cancer diagnosis. Additionally, each participant met at least one of the following criteria: living in a medically underserved area, having low literacy, low income (defined as 100% of the 2015 Federal Poverty Level FPL according to 2015 FPL Guidelines), or being uninsured or receiving subsidized health insurance coverage. Participants completed a baseline survey of demographic data, health status, including health behaviors and risk factors to cancer, Primary Care Physician (PCP) status and most recent breast, cervical, prostate, skin and colorectal cancer screenings. Information related to discrimination, acculturation or adaptation, and sense of belonging to their community was collected using validated instruments. RESULTS/ANTICIPATED RESULTS: Of the 333 participants enrolled in the study, 65.5% were women, 14.1% were 40-50 years of age, 59.8% were 51-64 years, and 26.1% were 65-74. The cohort was racially and ethnically diverse: 8.4% of participants identified as Hispanic, 30.3% as non-Hispanic White, 31.2% as non-Hispanic Black, 29.4% as non-Hispanic Asian, and 0.6% as Other. 62.2% spoke English, 8.1% Spanish, and 29.7% Chinese as their primary language. Low incomes were common: 33.6% reported incomes $15,000 or less, and 25.8% reported incomes between $15,000 and $24,999. Overall adherence to USPSTF guidelines on cancer screening rates was 77.9% for breast cancer, 71.1% for cervical cancer, and 67.7% for colorectal cancer. Analyses will present the association of acculturation, community identity, and discrimination with cancer screening and quality of life measures. DISCUSSION/SIGNIFICANCE OF IMPACT: This study will promote the increase of cancer disparities research, and reinforce the importance of inclusion and increased recruitment of diverse populations in future studies. By determining the potential factors associated with cancer disparities among minority populations, it may provide new information for clinicians to have more cultural sensitivity addressing potential disparities in the clinical setting. It will also promote the creation of more tailored interventions and programs to deliver adequate healthcare among these populations.
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Tandra, Anand, Leland Metheny, David Yao, Paolo F. Caimi, Lauren Brister, Brenda Cooper, Hillard M. Lazarus, et al. "Low Dose Antithymocyte Globulin (ATG) for Graft-Versus-Host Disease (GVHD) Prophylaxis." Blood 128, no. 22 (December 2, 2016): 5788. http://dx.doi.org/10.1182/blood.v128.22.5788.5788.
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Abstract ATG appears to reduce the incidence of acute and chronic GVHD after allogeneic hematopoietic stem cell transplantation (HSCT). Potential risks of this strategy include viral reactivation, delayed immune recovery and increased relapse rates. The ideal dosing of rabbit ATG in this context is largely unknown. We therefore hypothesized that low dose ATG would reduce the incidence of acute and chronic GVHD in matched unrelated donor (MUD) transplants without compromising survival and relapse rate. A retrospective analysis was performed of a cohort of high-risk MUD HSCT recipients treated since year 2013, when our practice changed to include rabbit ATG at 3 mg/Kg for all MUD transplants at the Case Medical Center in Cleveland, Ohio. Herein we present the results of this analysis. Methods. 58 MUD transplants were performed between years 2013 and 2016, with a median follow up of 262 days post-transplant. All donor-recipient pairs were matched by high resolution HLA typing at HLA-A, -B, -C, and DRB1, (8/8 matches) with the exception of 4 pairs (7/8 matches. Median age was 56 years (range, 53-64). Underlying diagnoses were AML (n=26), MDS (13), CML (n=5), NHL (n=9), Hodgkin's lymphoma (n=2), Multiple Myeloma (n=1) and myeloproliferative disorders (n=2). Preparative regimens were ablative in 26 cases (45 %) and of reduced intensity in 31 cases (55 %). Graft source was bone marrow (n=5) and peripheral blood (n=53). All but 4 pts received GVHD prophylaxis with tacrolimus, and mini-methotrexate (5 mg/m2 on days +1, +3, +6 and +11), in addition to rabbit ATG 3 mg/Kg divided in two doses on days -2 and -1 pre HSCT. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Human Herpes Virus (HHV6) PCR were conducted thrice weekly during the first 100 days after HSCT. Results. The 100-day cumulative incidence of grade II-IV acute GVHD was 41% (95% CI: 29-57; Fig 1), while the cumulative incidence of grade III-IV acute GVHD was 18% (95% CI: 9-35; Fig 2). 1-year cumulative incidence of chronic GVHD was 27% (95% CI: 17-42; Fig 3). At 180 days, the incidence of CMV viremia (defined as more than 1,000 copies/mL) was 25% (95% CI: 16-40), while the incidence of EBV and of HHV6 viremia was 35% (95% CI: 24-51) and 14% (95% CI: 8-27), respectively. There was no instance of EBV-related lymphoproliferative disorder. 3-year overall survival estimate is 48% (95% CI: 34-62). Cumulative incidence of Non-relapse mortality (NRM) and relapse at 1 year was 21% (95% CI: 12-37) and 44% (95% CI: 29-65), respectively. Conclusion. Our study shows that low dose rabbit ATG appears to reduce chronic GVHD rates without a major effect on acute GVHD incidence. CMV, EBV and HHV6 reactivation did occur, albeit at rates that are somewhat lower than those historically reported, without EBV-driven lymphoproliferative disorder. Disclosures Caimi: Genentech: Speakers Bureau; Roche: Research Funding; Novartis: Consultancy; Gilead: Consultancy.
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Messerschmidt, C. A., F. M. Abreu, L. H. Cruppe, M. V. Biehl, M. L. Day, C. R. F. Pinto, and M. A. Coutinho da Silva. "9 EFFECTS OF MECLOFENAMIC ACID ON LUTEAL FUNCTION OF BEEF CATTLE." Reproduction, Fertility and Development 24, no. 1 (2012): 115. http://dx.doi.org/10.1071/rdv24n1ab9.
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The objective of this study was to determine the effects of meclofenamic acid, a nonsteroidal anti-inflammatory, on luteal function of beef cattle. A total of 18 Angus cows, aged between 2 and 3 years old, were enrolled in the experiment. All cows were synchronized using a 5-day CIDR protocol. Briefly, cows received 100 μg of gonadorelin diacetate tetrahydrate (GnRH; Cystorelin®, Merial, Athens, GA, USA) and a controlled internal drug release insert (CIDR; Eazi-BreedTM CIDR®, Pfizer Animal Health, New York, NY, USA). Five days later, the CIDR was removed and 50 mg of dinoprost (Lutalyse®, Pfizer Animal Health) was administered intramuscularly. Oestrus was determined by twice daily observations of mounting behaviour and tail painting scores (day of oestrus = Day 0). At 72 h after dinoprost, a second dose of gonadorelin (100 μg, IM) was administered. On Day 14, cows were randomly assigned to the following treatment groups: 1) control: 10 mL of saline solution administered IM; 2) systemic: 2 g of meclofenamic acid administered IM; and 3) oral: 2 g of meclofenamic acid administered orally. Cows were treated once daily for 11 days (i.e. until Day 24) and no adverse reactions were observed. Blood sampling and ovarian ultrasonography were performed every 72 h from Day 0 until Day 12 and then every 48 h until the end of the study. Serum progesterone concentrations were determined by radioimmunoassay and were used to determine functional luteolysis (i.e. progesterone <1 ng mL–1). Ovaries were evaluated for the presence of a corpus luteum and to evaluate follicular growth and subsequent ovulation. One-way ANOVA was used to compare the day of peak progesterone concentration, lifespan of the corpus luteum and the length of the oestrous cycle between groups. Significance was set at P < 0.05 and data are presented as means ± standard error of the mean (Table 1). There were no effects of meclofenamic acid administration on any of the parameters evaluated (P > 0.05). In conclusion, meclofenamic acid administration did not affect luteal function in our study. Potentially, higher doses of meclofenamic acid may be necessary to inhibit prostaglandin synthesis and prevent luteolysis. Table 1.Effects of meclofenamic acid administration on the day of peak progesterone concentration, lifespan of the corpus luteum (CL) and the length of oestrous cycle in beef cows (mean ± standard error of the mean) Funding was provided by The Ohio State University, College of Veterinary Medicine, USDA-Animal Health Formula Funds. The authors are also grateful to the staff at the OSU Beef Center Facility for helping with animal handling and care.