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1

Taber, Douglass F., and Weiwei Tian. "Synthesis of (−)-Hamigeran B." Journal of Organic Chemistry 73, no. 19 (October 3, 2008): 7560–64. http://dx.doi.org/10.1021/jo8010683.

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2

Clive, Derrick L. J., and Jian Wang. "Synthesis of natural (−)-hamigeran B." Tetrahedron Letters 44, no. 42 (October 2003): 7731–33. http://dx.doi.org/10.1016/j.tetlet.2003.08.089.

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3

Clive, Derrick L. J., and Jian Wang. "Synthesis of (±)-Hamigeran B, (−)-Hamigeran B, and (±)-1-epi-Hamigeran B: Use of Bulky Silyl Groups to Protect a Benzylic Carbon−Oxygen Bond from Hydrogenolysis." Journal of Organic Chemistry 69, no. 8 (April 2004): 2773–84. http://dx.doi.org/10.1021/jo030347v.

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4

Jiang, Biao, Ming-ming Li, Ping Xing, and Zuo-gang Huang. "A Concise Formal Synthesis of (−)-Hamigeran B." Organic Letters 15, no. 4 (February 4, 2013): 871–73. http://dx.doi.org/10.1021/ol400030a.

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5

Mukherjee, Herschel, Nolan T. McDougal, Scott C. Virgil, and Brian M. Stoltz. "A Catalytic, Asymmetric Formal Synthesis of (+)-Hamigeran B." Organic Letters 13, no. 5 (March 4, 2011): 825–27. http://dx.doi.org/10.1021/ol102669z.

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6

Trost, Barry M., Carole Pissot-Soldermann, and Irwin Chen. "A Short and Concise Asymmetric Synthesis of Hamigeran B." Chemistry - A European Journal 11, no. 3 (January 21, 2005): 951–59. http://dx.doi.org/10.1002/chem.200400558.

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7

Li, Ruo-Xin, Rui Han, Guo-Jie Wu, Fu-She Han, and Jin-Ming Gao. "Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators." Marine Drugs 18, no. 6 (June 11, 2020): 306. http://dx.doi.org/10.3390/md18060306.

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We describe the efficient synthesis of a series of new simplified hamigeran B and 1-hydroxy-9-epi-hamigeran B norditerpenoid analogs (23 new members in all), structurally related to cyathane diterpenoid scaffold, and their anti-neuroinflammatory and neurite outgrowth-stimulating (neurotrophic) activity. Compounds 9a, 9h, 9o, and 9q exhibited moderate nerve growth factor (NGF)-mediated neurite-outgrowth promoting effects in PC-12 cells at the concentration of 20 μm. Compounds 9b, 9c, 9o, 9q, and 9t showed significant nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-activated BV-2 microglial cells, of which 9c and 9q were the most potent inhibitors, with IC50 values of 5.85 and 6.31 μm, respectively. Two derivatives 9q and 9o as bifunctional agents displayed good activities as NO production inhibitors and neurite outgrowth-inducers. Cytotoxicity experiments, H2O2-induced oxidative injury assay, and ELISA reaction speculated that compounds may inhibit the TNF-α pathway to achieve anti-inflammatory effects on nerve cells. Moreover, molecular docking studies provided a better understanding of the key structural features affecting the anti-neuroinflammatory activity and displayed significant binding interactions of some derivatives (like 9c, 9q) with the active site of iNOS protein. The structure-activity relationships (SARs) were also discussed. These results demonstrated that this structural class compounds offered an opportunity for the development of a new class of NO inhibitors and NGF-like promotors.
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8

Cao, Bao-Chen, Guo-Jie Wu, Fang Yu, Yu-Peng He, and Fu-She Han. "A Total Synthesis of (−)-Hamigeran B and (−)-4-Bromohamigeran B." Organic Letters 20, no. 12 (June 6, 2018): 3687–90. http://dx.doi.org/10.1021/acs.orglett.8b01490.

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9

Jiang, Biao, Ming-ming Li, Ping Xing, and Zuo-gang Huang. "ChemInform Abstract: A Concise Formal Synthesis of (-)-Hamigeran B (XIV)." ChemInform 44, no. 28 (June 21, 2013): no. http://dx.doi.org/10.1002/chin.201328176.

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10

Sperry, Jeffrey B., and Dennis L. Wright. "Synthesis of the hamigeran skeleton through an electro-oxidative coupling reaction." Tetrahedron Letters 46, no. 3 (January 2005): 411–14. http://dx.doi.org/10.1016/j.tetlet.2004.11.108.

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11

Cai, Zhengxin, and Michael Harmata. "Studies Directed toward the Synthesis of Hamigeran B: A Catalytic Oxidative Cyclization." Organic Letters 12, no. 24 (December 17, 2010): 5668–70. http://dx.doi.org/10.1021/ol102478h.

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12

Lau, Stephen Y. W. "Concise and Protective Group-Free Syntheses of (±)-Hamigeran B and (±)-4-Bromohamigeran B†." Organic Letters 13, no. 2 (January 21, 2011): 347–49. http://dx.doi.org/10.1021/ol102780s.

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13

Trost, Barry M., Carole Pissot-Soldermann, Irwin Chen, and Gretchen M. Schroeder. "An Asymmetric Synthesis of Hamigeran B via a Pd Asymmetric Allylic Alkylation for Enantiodiscrimination." Journal of the American Chemical Society 126, no. 14 (April 2004): 4480–81. http://dx.doi.org/10.1021/ja0497025.

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14

Jiang, Baiyang, and Mingji Dai. "11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C–H Functionalizations." Journal of the American Chemical Society 143, no. 48 (November 23, 2021): 20084–89. http://dx.doi.org/10.1021/jacs.1c11060.

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15

Mehta, Goverdhan, and Harish M. Shinde. "Enantiospecific total synthesis of 6-epi-(−)-hamigeran B. Intramolecular Heck reaction in a sterically constrained environment." Tetrahedron Letters 44, no. 37 (September 2003): 7049–53. http://dx.doi.org/10.1016/s0040-4039(03)01754-4.

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16

Breinholt, Jens, Anders Kjœr, Carl E. Olsen, Birgitte R. Rassing, and Connie N. Rosendahl. "Hamigerone and Dihydrohamigerone: Two Acetate-Derived, Antifungal Metabolites from Hamigera avellanea." Acta Chemica Scandinavica 51 (1997): 1241–44. http://dx.doi.org/10.3891/acta.chem.scand.51-1241.

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17

Kuwata, Kazuaki, Rie Fujita, Kengo Hanaya, Shuhei Higashibayashi, and Takeshi Sugai. "Formal total synthesis of (−)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center." Tetrahedron 74, no. 7 (February 2018): 740–45. http://dx.doi.org/10.1016/j.tet.2017.12.054.

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18

Woolly, Ethan F., A. Jonathan Singh, Euan R. Russell, John H. Miller, and Peter T. Northcote. "Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis." Journal of Natural Products 81, no. 2 (January 26, 2018): 387–93. http://dx.doi.org/10.1021/acs.jnatprod.7b00960.

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19

Miesch, Laurence, Tania Welsch, Vincent Rietsch, and Michel Miesch. "Intramolecular Alkynylogous Mukaiyama Aldol Reaction Starting from Bicyclic Alkanones Tethered to Alkynyl Esters: Formal Total Synthesis of (±)-Hamigeran B." Chemistry - A European Journal 15, no. 17 (April 20, 2009): 4394–401. http://dx.doi.org/10.1002/chem.200802309.

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20

Lin, Han, Li-Jun Xiao, Min-Jie Zhou, Hong-Ming Yu, Jian-Hua Xie, and Qi-Lin Zhou. "Enantioselective Approach to (−)-Hamigeran B and (−)-4-Bromohamigeran B via Catalytic Asymmetric Hydrogenation of Racemic Ketone To Assemble the Chiral Core Framework." Organic Letters 18, no. 6 (March 4, 2016): 1434–37. http://dx.doi.org/10.1021/acs.orglett.6b00369.

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21

Clive, Derrick L. J., and Jian Wang. "Stereospecific Total Synthesis of the Antiviral Agent Hamigeran B—Use of Large Silyl Groups to Enforce Facial Selectivity and to Suppress Hydrogenolysis." Angewandte Chemie International Edition 42, no. 29 (July 28, 2003): 3406–9. http://dx.doi.org/10.1002/anie.200351519.

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22

Dattelbaum, Jonathan D., A. Jonathan Singh, Jessica J. Field, John H. Miller, and Peter T. Northcote. "The Nitrogenous Hamigerans: Unusual Amino Acid-Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis." Journal of Organic Chemistry 80, no. 1 (December 4, 2014): 304–12. http://dx.doi.org/10.1021/jo502370b.

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23

Singh, A. Jonathan, Jonathan D. Dattelbaum, Jessica J. Field, Zlatka Smart, Ethan F. Woolly, Jacqueline M. Barber, Rosemary Heathcott, John H. Miller, and Peter T. Northcote. "Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity." Organic & Biomolecular Chemistry 11, no. 46 (2013): 8041. http://dx.doi.org/10.1039/c3ob41305e.

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24

Dattelbaum, Jonathan D., A. Jonathan Singh, Jessica J. Field, John H. Miller, and Peter T. Northcote. "ChemInform Abstract: The Nitrogenous Hamigerans: Unusual Amino Acid-Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis." ChemInform 46, no. 21 (May 2015): no. http://dx.doi.org/10.1002/chin.201521227.

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25

Cambie, Richard C., Clifton E. F. Rickard, P. Stewart Rutledge, and Keri D. Wellington. "Hamigerin A and a hamigerin D decomposition product." Acta Crystallographica Section C Crystal Structure Communications 57, no. 8 (August 9, 2001): 958–60. http://dx.doi.org/10.1107/s0108270101007442.

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26

Singh, A. Jonathan, Jonathan D. Dattelbaum, Jessica J. Field, Zlatka Smart, Ethan F. Woolly, Jacqueline M. Barber, Rosemary Heathcott, John H. Miller, and Peter T. Northcote. "ChemInform Abstract: Structurally Diverse Hamigerans from the New Zealand Marine Sponge Hamigera tarangaensis: NMR-Directed Isolation, Structure Elucidation and Antifungal Activity." ChemInform 45, no. 15 (March 27, 2014): no. http://dx.doi.org/10.1002/chin.201415217.

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27

Hassan, Wafaa, RuAngelie Edrada, Rainer Ebel, Victor Wray, and Peter Proksch. "New Alkaloids from the Mediterranean Sponge Hamigera hamigera." Marine Drugs 2, no. 3 (August 25, 2004): 88–100. http://dx.doi.org/10.3390/md203088.

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28

NAKAYAMA, MOTOKAZU, KOUICHI HOSOYA, TETSUHIRO MATSUZAWA, YUSUKE HIRO, AYUMI SAKO, HAJIME TOKUDA, and TAKASHI YAGUCHI. "A Rapid Method for Identifying Byssochlamys and Hamigera." Journal of Food Protection 73, no. 8 (August 1, 2010): 1486–92. http://dx.doi.org/10.4315/0362-028x-73.8.1486.

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Heat-resistant fungi, genera Byssochlamys, Talaromyces, Neosartorya, and Hamigera, contribute significantly to the spoilage of heat-processed acidic foods, due to the formation of heat-resistant ascospores. Here, we first evaluated the differences in the β-tubulin gene between Byssochlamys and Hamigera and developed specific primers to identify the Byssochlamys species fulva, nivea, and spectabilis, and Hamigera. Using primers designed for B. fulva and B. nivea (B1F/1R), specific PCR products were detected for B. fulva and B. nivea, as well as B. langunculariae and B. zollerniae, two closely related species. Similarly, the Pae4F/4R-1 and H2F/2R primers produced specific PCR products for B. spectabilis and Hamigera, respectively. Using these three primer sets, strains involved in acidic food spoilage and environmental contamination were not detected. The detection limits of all primer sets were 1 ng of DNA by PCR and 10 pg of DNA by nested PCR. Each PCR assay was specific, even if the sample was contaminated 1,000-fold by other fungal DNA. Thus, this method has proved to possess an extremely high degree of specificity.
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29

Cambie, Richard C., Clifton E. F. Rickard, P. Stewart Rutledge, and Keri D. Wellington. "ChemInform Abstract: Hamigerin A (I) and a Hamigerin D Decomposition Product (II)." ChemInform 32, no. 50 (May 23, 2010): no. http://dx.doi.org/10.1002/chin.200150179.

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30

Li, Xiaojun, Dongsheng Xue, Cheng Wang, and Shuanhu Gao. "Total Synthesis of the Hamigerans." Angewandte Chemie International Edition 55, no. 34 (July 8, 2016): 9942–46. http://dx.doi.org/10.1002/anie.201604070.

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31

Li, Xiaojun, Dongsheng Xue, Cheng Wang, and Shuanhu Gao. "Total Synthesis of the Hamigerans." Angewandte Chemie 128, no. 34 (July 8, 2016): 10096–100. http://dx.doi.org/10.1002/ange.201604070.

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32

Clive, Derrick L. J., and Jian Wang. "SYNTHESIS OF THE HAMIGERANS. A REVIEW." Organic Preparations and Procedures International 37, no. 1 (February 2005): 1–35. http://dx.doi.org/10.1080/00304940509355400.

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33

Madu, Christian E., and Carl J. Lovely. "A Pauson−Khand Approach to the Hamigerans." Organic Letters 9, no. 23 (November 2007): 4697–700. http://dx.doi.org/10.1021/ol7018604.

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34

Breinholt, Jens, Anders Kjær, Carl E. Olsen, Birgitte R. Rassing, Jo Klaveness, Frode Rise, Kjell Undheim, et al. "A Bis-formamidodiphenylbutadiene from the Fungus Hamigera avellanea." Acta Chemica Scandinavica 50 (1996): 643–45. http://dx.doi.org/10.3891/acta.chem.scand.50-0643.

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35

Romero, Stella Maris, Andrea Irene Romero, Alberto Miguel Stchigel, Ernesto Rodríguez Andrade, Viviana Andrea Barrera, José Francisco Cano, and Ricardo Comerio. "Biodiversity of heat-resistant ascomycetes from semi-arid soils in Argentina." Mycotaxon 135, no. 3 (October 16, 2020): 535–58. http://dx.doi.org/10.5248/135.535.

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Artificial thermal shock conducted on 50 soil samples from a semi-arid geographic region (Catamarca and La Rioja provinces) in northern Argentina yielded 34 heat-resistant fungal strains. These strains were assigned to seventeen taxa in ten ascomycete genera: Arthrinium (1), Aspergillus (3), Epicoccum (1), Gilmaniella (1), Hamigera (2), Leiothecium (1), Penicillium (2), Talaromyces (4), Trichocladium (1), and Trichoderma (1). All strains were identified by phenotypic features, with molecular data additionally obtained for eleven strains. Five species are reported for the first time in Argentina.
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36

Jiang, Baiyang, and Mingji Dai. "Synthetic Studies toward the Hamigerans with a 6–7–5 Tricyclic Core." Organic Letters 22, no. 11 (May 13, 2020): 4176–79. http://dx.doi.org/10.1021/acs.orglett.0c01253.

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37

BERTOLINO, MARCO, GABRIELE COSTA, ANNA REBOA, GIORGIO BAVESTRELLO, MAURIZIO PANSINI, FEDERICO BETTI, MARZIA BO, and GIOVANNI DANERI. "The sponge fauna of the Seno Magdalena and Puyuhuapi Fjord (Chile), with a description of two new species." Zootaxa 4623, no. 2 (June 25, 2019): 306–20. http://dx.doi.org/10.11646/zootaxa.4623.2.5.

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The presence of fjords, islands and channels originating from glacial erosion and ice cap retreat, makes the Chilean benthic biodiversity difficult to explore and study. Our survey of this region allowed the identification of 29 Demospongiae species in total. Two of them are new to science and here described: Biemna lutea sp. nov., and Hamigera cleistochela sp. nov.. Two species (Clathria (Clathria) microxa and Lissodendoryx (Ectyodoryx) patagonica,) are new for the region and the Chilean fjords. Lissodendoryx (Ectyodoryx) patagonica was found for the second time after the original description by Ridley & Dendy, 132 years ago. These results – considering the small number of species identified on the whole – are promising and confirm that the marine biodiversity of Chilean fjords is remarkable but not well known yet.
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38

BRUCE, A. J. "Pontoniine shrimps from the 2003 NORFANZ Expedition, 10 May–16 June (Crustacea: Decapoda: Palaemonidae)." Zootaxa 981, no. 1 (May 16, 2005): 1. http://dx.doi.org/10.11646/zootaxa.981.1.1.

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A report is presented on a small collection of pontoniine shrimps, from the Tasman Sea, by the 2003 NORFANZ Expedition. The report includes information on 5 taxa, including two species new to science, Periclimenes fenneri and P. tangeroa. Hamiger novaezealandiae Borradaile is now recorded for the first time since 1910.
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39

Cambie, Richard C., Allick R. Lal, Michael R. Kernan, and Patricia R. Bergquist. "Chemistry of Sponges, 17. A Novel Brominated Benzocylooctane Derivative from Hamigera taragensis." Journal of Natural Products 58, no. 6 (June 1995): 940–42. http://dx.doi.org/10.1021/np50120a020.

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40

Giridharan, Periyasamy, Shilpa A. Verekar, Akash R. Gohil, Prabhu Dutt Mishra, Amit Khanna, and Sunil Kumar Deshmukh. "Antiproliferative Activity of Hamigerone and Radicinol Isolated fromBipolaris papendorfii." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/890904.

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Secondary metabolites from fungi organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Through high throughput screening (HTS) and bioassay-guided isolation, we isolated two bioactive compounds hamigerone (1) and radicinol (2). These compounds were isolated from fungusBipolaris papendorfii, isolated from the rice fields of Dera, Himachal Pradesh, India. The structures of the compounds were established on the basis of spectroscopic data, namely, NMR (1H,13C, mass, and UV). Both compounds were found to be antiproliferative against different cancer cells. Furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (BCL-2), and in turn increase caspase-3 expression in cancer cells. This is the first report of these compounds from fungusBipolaris papendorfiiand their anticancer activity.
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41

Yamazaki, Mikio, Yoshikazu Horie, Kiewan Bae, Yukio Maebayashi, Yasuhiro Jisai, and Haruhiro Fujimoto. "New fungal metabolites avellanins A and B from Hamigera avellanea, with pressor effect." CHEMICAL & PHARMACEUTICAL BULLETIN 35, no. 5 (1987): 2122–24. http://dx.doi.org/10.1248/cpb.35.2122.

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42

Cheng, Jie-Fei, Jong-Soo Lee, Furong Sun, Elizabeth A. Jares-Erijman, Sue Cross, and Kenneth L. Rinehart. "Hamigerols A and B, Unprecedented Polysulfate Sterol Dimers from the Mediterranean SpongeHamigera hamigera." Journal of Natural Products 70, no. 7 (July 2007): 1195–99. http://dx.doi.org/10.1021/np070027x.

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43

Isaka, Masahiko, Panida Chinthanom, Surisa Kongthong, Sumalee Supothina, and Pataranun Ittiworapong. "Hamigeromycins C–G, 14-membered macrolides from the fungus Hamigera avellanea BCC 17816." Tetrahedron 66, no. 4 (January 2010): 955–61. http://dx.doi.org/10.1016/j.tet.2009.11.101.

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44

Almeida, Celso, Ignacio Pérez-Victoria, Víctor González-Menéndez, Nuria de Pedro, Jesús Martín, Gloria Crespo, Thomas Mackenzie, et al. "Non-geminal Aliphatic Dihalogenation Pattern in Dichlorinated Diaporthins from Hamigera fusca NRRL 35721." Journal of Natural Products 81, no. 6 (May 24, 2018): 1488–92. http://dx.doi.org/10.1021/acs.jnatprod.8b00041.

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45

Scaramuzza, Nicoletta, and Elettra Berni. "Heat-resistance of Hamigera avellanea and Thermoascus crustaceus isolated from pasteurized acid products." International Journal of Food Microbiology 168-169 (January 2014): 63–68. http://dx.doi.org/10.1016/j.ijfoodmicro.2013.10.007.

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46

KIKOKU, YUTAKA, NOBUHIRO TAGASHIRA, and HIROYUKI NAKANO. "Heat Resistance of Fungi Isolated from Frozen Blueberries." Journal of Food Protection 71, no. 10 (October 1, 2008): 2030–35. http://dx.doi.org/10.4315/0362-028x-71.10.2030.

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This study dealt with the isolation, characterization, and identification of the fungal microflora of frozen blueberries imported from Canada. The thermal inactivation rates of the rarely studied isolated heat-resistant molds, Devriesia spp. and Hamigera striata, in naturally and artificially contaminated blueberry slurries were also determined. The D-values of naturally contaminating Devriesia spp. at 70, 80, 85, and 90°C were 714, 114, 44.4, and 14.1 min, respectively. The D-values of H. striata at 70, 80, 85, and 90°C were 909, 286, 42.6, and 10.3 min, respectively. The z-values calculated from the thermal death time curves were 11.0 and 6.9°C for Devriesia spp. and H. striata, respectively. Results also showed that in both test mold species, the naturally occurring molds had significantly higher thermal resistance than did the artificially contaminated counterparts. The results established by this study may be used by blueberry processors to prevent losses due to spoilage caused by the heat-resistant microorganisms.
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47

Igarashi, Yasuhiro, Fumiya Gohda, Taito Kadoshima, Takao Fukuda, Tomoaki Hanafusa, Akane Shojima, Jiro Nakayama, Gerald F. Bills, and Stephen Peterson. "Avellanin C, an inhibitor of quorum-sensing signaling in Staphylococcus aureus, from Hamigera ingelheimensis." Journal of Antibiotics 68, no. 11 (May 6, 2015): 707–10. http://dx.doi.org/10.1038/ja.2015.50.

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48

Isaka, Masahiko, Panida Chinthanom, Sukitaya Veeranondha, Sumalee Supothina, and J. Jennifer Luangsa-ard. "Novel cyclopropyl diketones and 14-membered macrolides from the soil fungus Hamigera avellanea BCC 17816." Tetrahedron 64, no. 49 (December 2008): 11028–33. http://dx.doi.org/10.1016/j.tet.2008.09.077.

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49

NAKAO, Kazunari, Yasumasa HAMADA, and Takayuki SHIOIRI. "Total synthesis of avellanins A and B, new fungal metabolites from Hamigera avellanea with pressor effect." CHEMICAL & PHARMACEUTICAL BULLETIN 37, no. 4 (1989): 930–32. http://dx.doi.org/10.1248/cpb.37.930.

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50

Nicolaou, K. C., David L. F. Gray, and Jinsung Tae. "Total Synthesis of Hamigerans and Analogues Thereof. Photochemical Generation and Diels−Alder Trapping of Hydroxy-o-quinodimethanes." Journal of the American Chemical Society 126, no. 2 (January 2004): 613–27. http://dx.doi.org/10.1021/ja030498f.

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