Academic literature on the topic 'Haemoglobin concentration'

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Journal articles on the topic "Haemoglobin concentration"

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Hofmann, O., G. Carrucan, N. Robson, and T. Brittain. "The chloride effect in the human embryonic haemoglobins." Biochemical Journal 309, no. 3 (August 1, 1995): 959–62. http://dx.doi.org/10.1042/bj3090959.

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The interactions of the three human embryonic haemoglobins with chloride ions have been investigated. Each of the three embryonic haemoglobins exhibits a unique pattern of oxygen-affinity-dependence on chloride ion concentration. Human embryonic haemoglobin Portland (zeta 2 gamma 2) is found to be completely insensitive to chloride ion concentration. Haemoglobin Gower I (zeta 2 gamma 2) shows a small concentration dependence, whilst haemoglobin Gower II (alpha 2 epsilon 2) exhibits a dependence approaching that of the adult protein. The degree of co-operativity for each protein is essentially chloride concentration independent. The chloride-dependent and -independent components of the alkaline Bohr effects have been measured for each of the embryonic haemoglobins and compared with that of the adult protein. Both the chloride-binding data and the Bohr effect have been analysed in terms of the recently developed allosteric model proposed by Perutz [Perutz, Fermi, Poyart, Pagnier and Kister (1993) J. Mol. Biol. 233, 536-545].
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Appleby, CA, ES Dennis, and WJ Peacock. "A primaeval origin for plant and animal haemoglobins?" Australian Systematic Botany 3, no. 1 (1990): 81. http://dx.doi.org/10.1071/sb9900081.

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The discovery and study of haemoglobin and its genes in nitrogen-fixing nonleguminous plant root nodules and in the roots of non-nodulated and non-nodulating plants has shown that these haemoglobins, the leghaemoglobins of legume nodules, and animal haemoglobins, all have a common evolutionary origin. It would be simple to assume that they are related by vertical descent from a haemoglobin-containing proto-organism that evolved in the early biosphere some 1500 million years ago, but this might not be so. Recently, haemoglobin has been recognised in Vitreoscilla, a bacterium, and homology between this protein and its gene and animal and plant haemoglobins and their genes is demonstrated. This could mean that bacterial, plant and animal haemoglobins are related by vertical descent from haemoglobin present in a common proto-organism, possibly a primitive archaebacterium, that developed in the early Archean era more than 3500 million years ago. The known properties of contemporary plant and animal haemoglobins and their genes suggest that plant haemoglobin, with its ability to function at nanomolar concentration of free oxygen and its three-intron gene structure, could most resemble this putative primaeval haemoglobin.
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Chesterton, Lindsay, Stewart H. Lambie, Lisa J. Hulme, Maarten Taal, Richard J. Fluck, and Christopher W. McIntyre. "Online measurement of haemoglobin concentration." Nephrology Dialysis Transplantation 20, no. 9 (July 5, 2005): 1951–55. http://dx.doi.org/10.1093/ndt/gfh926.

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Airaksinen, S., and M. Nikinmaa. "Effect of haemoglobin concentration on the oxygen affinity of intact lamprey erythrocytes." Journal of Experimental Biology 198, no. 11 (November 1, 1995): 2393–96. http://dx.doi.org/10.1242/jeb.198.11.2393.

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We investigated whether the oxygen affinity of lamprey haemoglobin decreases with increasing oxygen concentration at the high (10­25 mmol l-1 monomeric) haemoglobin concentrations prevailing within the erythrocytes. The intracellular concentration of haemoglobin was experimentally adjusted by shrinking the cells osmotically: the osmolality of the equilibration medium was increased from approximately 250 mosmol kg-1 by 90 mosmol kg-1 to 340 mosmol kg-1 or by 180 mosmol kg-1 to 430 mosmol kg-1 by adding sucrose in the medium. This increased the mean cellular haemoglobin concentration from 16.9±0.23 mmol l-1 (monomeric haemoglobin) to 20.0±0.20 mmol l-1 (monomeric haemoglobin) and to 23.0±0.36 mmol l-1 (monomeric haemoglobin), respectively (means ± s.e.m., N=35­40; all the samples from 7­8 different pools of blood at each osmolality combined). The oxygen equilibrium curves at each osmolality were determined by Tucker's method. An increase in haemoglobin concentration shifted the oxygen equilibrium curve to the right as indicated by the P50 values, which were 4.26±0.07 kPa at the lowest, 4.64±0.13 kPa at the intermediate and 5.64±0.40 kPa (means ± s.e.m., N=7­8) at the highest haemoglobin concentrations. The decrease in haemoglobin oxygen-affinity was attributed to the volume changes, since the intracellular pH did not decrease with increasing mean cellular haemoglobin concentration. Thus, the variations in red blood cell volume commonly observed during hypoxia may play a role in the regulation of haemoglobin function.
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Symonds, Erin L., Joanne Osborne, Stephen R. Cole, Peter Bampton, Robert Fraser, and Graeme P. Young. "Gender differences in faecal haemoglobin concentration." Journal of Medical Screening 23, no. 1 (July 20, 2015): 54. http://dx.doi.org/10.1177/0969141315597018.

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Terwilliger, R. C., N. B. Terwilliger, G. M. Hughes†, A. J. Southward†, and E. C. Southward†. "Studies on the haemoglobins of the small Pogonophora." Journal of the Marine Biological Association of the United Kingdom 67, no. 1 (February 1987): 219–34. http://dx.doi.org/10.1017/s002531540002645x.

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Haemoglobin is present, often at high concentration, dissolved in the blood of all small Pogonophora so far examined.The haemoblobin of Siboglinum fiordicum resembles annelid and vestimentiferan haemoglobins in having subunits with molecular weights of 15000–16700 plus traces of 35000–40000 MW material. 5. fiordicum haemoglobin has 1 mol haem per 21500 g protein, and a similar lack of correspondence between subunits and mols of haem is shown by annelid and vestimentiferan haemoglobins. However, S. fiordicum haemoglobin differs considerably from annelid and vestimentiferan haemoglobins in other respects, even though the three groups are closely linked taxonomically. The haemoglobin of S. fiordicum has a lower apparent molecular weight (Mr = 3.5–4.0 x 105) than that of annelid haemoglobins (Mr = 3–4 x 108) when measured under the same conditions. Pogonophore blood examined with the electron microscope does not show the two-tiered hexagonal structure found in annelid and vestimentiferan haemoglobins. S. fiordicum haemoglobin also differs from annelid and vestimentiferan haemoglobins in amino acid composition.The haemoglobins of the small pogonophores examined have a very high affinity for oxygen. The P 50 ranges from 0.36 Torr in diluted blood of S. fiordicum (15 °C) to 0.5–1.0 Torr in undiluted blood of S. atlanticum (10 °C) and s. fiordicum (15 °C). Only a slight Bohr effect was found. The high oxygen affinity can be related to the wide range of P o2 values experienced in the habitat and the need to transport oxygen to the deeply buried posterior end of the body that contains autotrophic endosymbiotic bacteria.
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Nikinmaa, M. "Oxygen and carbon dioxide transport in vertebrate erythrocytes: an evolutionary change in the role of membrane transport." Journal of Experimental Biology 200, no. 2 (January 1, 1997): 369–80. http://dx.doi.org/10.1242/jeb.200.2.369.

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Two major strategies are apparent for the regulation of gas transport by vertebrate blood except in the myxinoids, which seem to have little scope for such regulation. In lampreys and teleost fish, haemoglobins have low buffering capacities and large Bohr/Haldane effects. Na+/H+ exchange plays an important role in the control of haemoglobin oxygen-affinity in these vertebrate groups. The large Bohr/Haldane effect also facilitates carbon dioxide transport: the blood (or erythrocyte) pH increases upon deoxygenation, thus increasing the concentration of bicarbonate formed at a given carbon dioxide tension. In lampreys, the bicarbonate permeability of the erythrocyte membrane is low. As a consequence, extracellular acid loads cannot be buffered by haemoglobin. In contrast, teleost erythrocytes possess a functional anion exchange, allowing extracellular proton loads to be buffered by haemoglobin. However, because the buffering capacity of teleost haemoglobins is low, buffering of extracellular acid loads is less effective in teleost fish than in elasmobranch fish and in air-breathing vertebrates whose haemoglobins have a high buffering capacity. However, the high buffering capacity of the haemoglobins diminishes the possibility of regulating haemoglobin oxygen-affinity via secondarily active Na+/H+ exchange, because intracellular pH changes, caused by proton efflux, remain small.
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Miike, Akira, Zensuke Ogawa, and Ikunosuke Sakurabayashi. "The development of an artificial stool usable for the surveillance of faecal haemoglobin testing." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 55, no. 3 (October 9, 2017): 394–99. http://dx.doi.org/10.1177/0004563217732587.

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Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneously contains not only human haemoglobin A0 (HbA0) but also glycerol as an internal standard material. After the collection of the artificial stool into a buffer, the haemoglobin concentration in dispersed solution was measured using a method based on the peroxidase like activity of haemoglobin. The glycerol concentration was measured using a commercially available triglyceride measurement kit. Results With regard to the haemoglobin stability, the decrease in the level of human haemoglobin in the artificial stool was <2% when it was stored at −80℃ for four months, −20℃ for two weeks, and 5℃ for two days. The artificial stool was easily collected with the collecting tubes of a commercially available faecal haemoglobin test kit. The weight of the collected artificial stool could be calculated by measuring the concentration of glycerol in the extracting solution of the collected stool sample. The haemoglobin concentrations could be adjusted based on their collection weights. Conclusions The artificial stool has a paste-like consistency and contains both haemoglobin and glycerol homogeneously. Furthermore, the measured haemoglobin concentration could be determined based on the collected stool weight, which was directly related to the glycerol concentration. These features make it a useful material for the surveillance of faecal occult blood testing.
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Amrithaashri S, Sridevi G, and Archana Santhanam. "Effect of decreased haemoglobin concentration on audio visual reaction time." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 16, 2020): 674–78. http://dx.doi.org/10.26452/ijrps.v11ispl3.3000.

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Anaemia is defined as the decrease in the blood with haemoglobin concentration and has also been a very important public health issue that extremely affects the middle-income countries. The present study was planned to investigate the association between haemoglobin concentration with audiovisual reaction time. The study was conducted among I year BDS female student population of saveetha dental college and hospital. Based on Haemoglobin values, the study population was divided into two categories. Group 1- Female subjects whose haemoglobin concentration was above 10 G %. Group 2(anaemic group)- Female subjects whose haemoglobin concentration was below 10 G%. Audiovisual reaction time was determined by the audio visual meter. The student's test was used to analyse the relationship between haemoglobin level and audiovisual reaction time The effect of age above and below 20 years also were analysed for haemoglobin and ART, VRT association. Pearson Chi square test was used to analyse the difference between normal and anaemic individuals in the age group above and below 20 years. The results of the analysis revealed that haemoglobin concentration was inversely proportional to Audio visual reaction time. The association analysis done between age groups with audiovisual reaction time in normal and anaemic participants did not show significant change. Thus, the present study concludes that haemoglobin concentration is inversely related to audio visual reaction time. This may be attributed to lower neural activity and impaired nerve conduction produced by anaemia.
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Chien, Kuo-Liong, Ting-Yu Lin, Chen-Yang Hsu, Chang-Chuan Chan, Tony Hsiu-Hsi Chen, and Li-Sheng Chen. "Association between faecal haemoglobin concentration and the risk of cardiovascular diseases among Taiwanese adults in a community-based screening cohort." BMJ Open 10, no. 6 (June 2020): e032633. http://dx.doi.org/10.1136/bmjopen-2019-032633.

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ObjectivesThe role of faecal haemoglobin as a colorectal cancer screening tool has been demonstrated. However, the association between the faecal haemoglobin concentration and the risk of cardiovascular disease events and deaths is still unclear.DesignCohort study design.SettingPopulation-based organised integrated service screening in Keelung City, TaiwanParticipantsA total of 33 355 healthy individuals aged over 40 years who were free of cardiovascular disease at study entry were followed up.Main outcomes and measuresNewly diagnosed cardiovascular disease events and deaths.ResultsAfter a median follow-up of 2.39 years, a total of 2768 participants developed cardiovascular events, and after a median follow-up of 8.43 years, 317 cases of cardiovascular deaths occurred. The risk of cardiovascular disease increased with baseline faecal haemoglobin in a dose–response manner, yielding a significant elevated risk of cardiovascular disease in parallel with the incremental concentration of faecal haemoglobin (adjusted HRs=1.04, 1.10, 1.40 and 1.23 for faecal haemoglobin concentrations of 1–19, 20–49, 50–99 and ≥100 ng/mL, trend test, p<0.0001, as compared with the reference group with undetectable faecal haemoglobin concentrations). A similar pattern was observed for the risk of cardiovascular disease deaths. In addition, the faecal haemoglobin improved the prediction performance of the model for the risk of cardiovascular diseases; the integrated discrimination improvement was 0.3% (p<0.001) for cardiovascular events and 0.1% (p=0.020) for cardiovascular deaths.ConclusionsOur data support that faecal haemoglobin concentrations may be associated with the risk of cardiovascular diseases. The biological mechanisms underlying the role of faecal haemoglobin as health outcomes should be investigated.
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Dissertations / Theses on the topic "Haemoglobin concentration"

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Digby, Jayne. "The relationship between faecal haemoglobin concentration and risk of significant colorectal neoplasia in screening and symptomatic populations." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/278e46d6-762b-4a0e-a2cc-3a3cbf475d52.

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Faecal immunochemical tests for haemoglobin (FIT) are replacing traditional guaiac-based faecal occult blood (gFOBT) tests in bowel screening programmes due to their many advantages. An evaluation of using quantitative FIT within the Scottish Bowel Screening Programme (SBSP) has taken place with faecal haemoglobin (Hb) concentration recorded for 38,720 participants. Subsequently, it has been established that faecal Hb concentration is related to severity of colorectal neoplastic disease, with higher median faecal Hb concentration in participants with advanced neoplasia compared to those with less severe outcomes (200.0 v. 166.0 µg Hb/g faeces, p < 0.0001). Those with elevated faecal Hb concentration (60.0 - 79.9 µg Hb/g faeces) at the time of a negative test result (< 80.0 µg Hb/g faeces) were more likely to be later diagnosed with an interval cancer than those with undetectable Hb (adjusted odds ratio = 24.7, 95% CI: 4.9 - 124.6). Follow-up of participants with a negative test result then testing positive in the subsequent screening round allowed calculation of an adjusted odds ratio of 38.0 (95% CI: 20.2 – 71.2) for advanced neoplasia in those with initial faecal Hb concentration 60.0 - 79.9 µg Hb/g faeces compared to those with faecal Hb concentration < 20.0 µg Hb/g faeces. These results give firm support to the role of faecal Hb concentration as a strong predictor of future risk of advanced neoplasia. The use of FIT in symptomatic patients was also evaluated, with results showing that using a cut-off faecal Hb concentration of any detectable Hb would have ruled out colorectal cancer and could have reduced the referral rate by 40%. With introduction of FIT now approved for the SBSP, it is hoped that a risk scoring system can be developed based on age, gender and faecal Hb concentration to better direct colonoscopy resource and reduce the proportion of interval cancers.
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Chipchase, Jeremy. "The use of intensity modulated optical spectroscopy to measure cerebral saturation and haemoglobin concentration in the human fetus during labour." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444401/.

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Background: Although intrapartum hypoxia-ischaemia is an important cause of death and permanent brain injury, current available methods for the detection of damaging fetal hypoxia are unsatisfactory and unreliable. Electronic fetal heart rate monitoring (EFM) is considered to be the "gold standard" for intrapartum fetal surveillance. However, monitoring of the fetal heart rate provides an indirect measure of fetal hypoxia and provides little indication of the adequacy of cerebral perfusion. Consequently, EFM has a false positive rate of 99.8% in the detection of fetuses that subsequently develop cerebral palsy. A direct consequence of the poor specificity of fetal heart rate monitoring is a high rate of unnecessary Caesarean sections with associated fetal and maternal morbidity. Most fetuses subjected to intrapartum hypoxia will be protected from brain injury by appropriate changes in cardiovascular distribution. It is the aim of fetal surveillance to detect the minority of fetuses in whom this response is absent and who are at risk of permanent brain injury. Intrapartum fetal pulse oximetry is a promising new method of fetal surveillance, enabling measurement of fetal arteriolar saturation but the technique provides no direct information on cerebral oxygen delivery. Intrapartum measurement of fetal cerebral saturation and changes in blood volume has been described using conventional near infrared spectroscopy (NIRS). However, the clinical relevance of these values may be limited. This is because these values are derived from changes in the concentrations of oxyhaemoglobin (HbCh) and deoxyhaemoglobin (Hb) from an arbitrary baseline. Furthermore, the contribution of artefact to NIRS measurements of Hb and HbC>2 changes, arising from possible changes in the geometry of the NIRS fetal probes during uterine contractions, has not been clearly defined. Using novel methods of collection and analysis of NIRS data, the technique of Intensity Modulated Optical Spectroscopy (IMOS) has the unique potential to provide direct information on fetal cerebral oxygenation and perfusion during labour from measured absolute values of fetal cerebral Hb02 and Hb. Furthermore, the technique of IMOS has the potential to provide more information on the contribution of probe movement during uterine contractions to conventional NIRS data.;Aims: The aims of this project were therefore to use this new technique of intensity modulated optical spectroscopy to (a) provide the first measurements of absolute cerebral blood volume and cerebral saturation in healthy normoxic human fetuses during labour and (b) to compare these values with those calculated from fetuses that develop hypoxia-ischaemia during labour and (c) to assess the contribution of probe movement during uterine contractions.;Methods: After assessing and optimising the technical performance of a specially designed and constructed intensity modulated optical spectrometer, a specially designed optical probe was placed against the scalp of 29 fetuses after rupture of amniotic membranes during labour and connected to the spectrometer.;Results: Of these 29 fetuses, data were collected from 18 fetuses during the first and second stage of labour through to delivery. Of these 18, data was suitable for analysis in 10 of these fetuses. In these 10 fetuses, a mean (+/-1 S.D.) value of cerebral saturation of 59 +/-12 % and a mean absolute cerebral blood volume of 2.8 +/-1.0mls/100g over 3 uterine contractions were derived from the mean concentrations of Hb and Hb02 of 30 +/-18 and 46 +/-21 umol/1, respectively. Concentration changes rather than artefact appeared to dominate the NIR signal in the calculation of these values.;Conclusion: This work has provided the first measurements of absolute values of fetal cerebral oxygenation and of cerebral perfusion, whilst the contribution of artefact to the data, certainly in the healthy fetus, appears to be negligible. However, despite these advances in near infrared technology and knowledge of intrapartum fetal cerebral haemodynamics, the number of fetuses studied with near infrared spectroscopy, in particular IMOS, remains small. In order for IMOS to be subjected to larger studies to assess it's usefulness as a realistic adjunct to fetal heart rate monitoring, advances in the technology are still required.
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Gordon, Christopher, and res cand@acu edu au. "Hydrostatic and thermal influences on intravascular volume determination during immersion: quantification of the f-cell ratio." Australian Catholic University. School of Exercise Science, 2001. http://dlibrary.acu.edu.au/digitaltheses/public/adt-acuvp4.14072005.

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Previous data have shown that the most prevalent, indirect plasma volume (PV) measurement technique, which utilises changes in haematocrit (Hct) and haemoglobin concentration ([Hb]), underestimates actual PV changes during immersion, when compared to a direct tracer-dilution method. An increase in the F-cell ratio (whole-body haematocrit (Hctw) to large-vessel haematocrit (Hctv) ratio) has been purported as a possible explanation, probably due to hydrostatic and thermally-mediated changes during water immersion. Previous investigators have not quantified the F-cell ratio during immersion. Therefore, this study sought to determine the effect of the F-cell ratio on the indirect method during both, thermoneutral and cold-water immersions. Seven healthy males were tested three times, seated upright in air (control: 21.2°C SD ±1.1), and during thermoneutral (34.5oC SD ±0.2) and cold-water immersion (18.6oC SD ±0.2), immersed to the third intercostal space for 60 min. Measurements during the immersion tests included PV (Evans blue dye column elution, Evans blue dye computer programme, and Hct [Hb]), red cell volume (RCV; sodium radiochromate), cardiac frequency (fc) and rectal temperature (Tre). Plasma volume during the control trial remained stable, and equivalent across the three tests. There was a hydrostatically-induced increase in PV during thermoneutral immersion, when determined by the Evans blue dye method (16.2%). However, the Hct/[Hb] calculation did not adequately reflect this change, and underestimated the relative PV change by 43%. In contrast, PV decreased during cold immersion when determined using the Evans blue dye method by 17.9% and the Hct/[Hb] calculation by 8.0%, respectively, representing a 52% underestimation by the latter method. There was a non-significant decline in RCV during both immersions. Furthermore, an increase (8.6%) and decrease (-14.4%) in blood volume (BV) was observed during thermoneutral and cold-water immersions, respectively. The decline in RCV during thermoneutral immersion attenuated the BV expansion. Despite the disparity between the PV methods, there was no increase in the F-cell ratio during either immersion. In contrast, there was a significant decline in the F-cell ratio during the control: air and thermoneutral immersion, which may indicate that other, undefined variables may impact on the stability of the red cell compartment. The current study is the first to show that the Hct/[Hb] method clearly underestimates PV changes during both thermoneutral and cold-water immersion. Furthermore, RCV was shown, for the first time, to decline during both immersions. However, the changes in the F-cell ratio during this study, did not account for the underestimation of PV change using the Hct/[Hb] method.
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Gustavsson, Frida. "Validation study : HemoCue Hb 201 + as a tool in comparative physiological field studies on avian blood." Thesis, Linköpings universitet, Biologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120106.

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Haemoglobin concentration is becoming a widely popular parameter to use to assess physiological condition within a broad range of species. Assessments of large populations would preferable be done in field to receive quick results and avoid confounding factors associated with transport of blood. A validation study is here performed to see how well the point-of-care device HemoCue Hb 201 + can assess haemoglobin concentration on avian blood. Nucleated erythrocytes have previously been pointed out as something that makes it problematic to apply HemoCue Hb 201 +, designed for human blood, on avian blood. Here it is shown that HemoCue Hb 201 + accurately can estimate haemoglobin concentration for chicken-, tinamou-, and ostrich blood. However, manipulation of ostrich cells, to yield a larger mean corspuscular volume, results in HemoCue Hb 201 + overestimating haemoglobin concentration. A large mean corpuscular volume could therefore be something that impair accuracy in values retrieved with HemoCue Hb 201 +. This study shows that HemoCue Hb 201 + seems possible to apply on avian blood to some extent, but highlights the importance of validation studies when applying this device on new species.
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Sheik, Hafsa. "The influence of a blood donors sitting position during time of waiting on the change of haemoglobin concentration during blood donation." Thesis, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349266.

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The routines for blood testing were changed during 2010 at the blood bank in UAS. At first, the blood test was taken before the donation and now it is taken after donation. Along with this, the blood bank increased the lowest level for allowance of blood donation with 10 g/L both for men and women. The level is now on 125 g/L and 135 g/L for women respectively men. After the increase, it was noticed that the amount of blood donors were deferred due to low Hb levels in creased. A study made in year 2013, investigated how much the Hb-levels actually was changed during a blood donation. It showed that it was lowered in means by 6 g/L and not 10 g/L as previously thought.The aim of this study was to see if the sitting position of the blood donor during waiting time and the supine position during the time of blood donation may had any effect on the difference of the Hb-level during the blood donation.Data from the 120 blood donors in the earlier study was collected. Hb values, before and after blood donation, were taken from the earlier study and registered times were taken from the database Prosang. The waiting time, time of blood donation and the difference of Hb-levels were calculated and correlated with Spearmanns correlation coefficient.The results did not show any correlation between the times and the difference in Hb-levels. One of the reasons may be that the blood donor physiology differ and thus the change in Hb-level can vary.
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Vucea, Valentina. "Les dérivées de l’hémoglobine dans la structure rétinienne par la technique de réflectométrie multi-spectrale." Thèse, 2013. http://hdl.handle.net/1866/12732.

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Books on the topic "Haemoglobin concentration"

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Raine, Tim, James Dawson, Stephan Sanders, and Simon Eccles. Haematology. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199683819.003.0013.

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AnaemiaTransfusion of blood productsClotting emergenciesBleedingAnticoagulationReduced red blood cell (RBC) mass, usually conveniently approximated as reduced haemoglobin concentration (eg ♂ <130g/L, ♀ <115g/L1). Causes easily divide into 3 basic mechanisms (reduced RBC production, increased RBC des-truction, RBC loss) with clues found in abnormalities of RBC size and shape....
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Hendriks, Herman G. D., and Joost T. M. de Wolf. Haematological and coagulation disorders and anaesthesia. Edited by Philip M. Hopkins. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0084.

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This chapter covers the principal haematological disorders and their implications for anaesthesia. Haemoglobin concentration is the main determinant of oxygen delivery to the tissues making anaemia a potential concern for the anaesthetist. In deciding whether to correct anaemia with a red blood cell transfusion, the anaesthetist must consider the nature of the surgery and the underling cause of the anaemia as well as the haemoglobin concentration. Techniques to limit the need for blood transfusion and the complications of transfusion are discussed. Perfect haemostasis means control of bleeding without the occurrence of thrombotic events. Coagulation management requires an understanding of this balance and the knowledge that altered coagulation activity may result in clinically relevant bleeding or, in contrast, thrombosis. Therefore, the key in haemostasis is an understanding that every anticoagulant action enhances the risk of bleeding and every procoagulant action enhances the risk of thrombosis. If a specific defect in the haemostatic system is known, treatment is tailored to restore this defect. However, tests to predict surgical bleeding do not exist, as it is for test to predict thrombotic events. The strengths and limitations of coagulation tests should be appreciated before they are used to assist clinical decision-making in the perioperative period. An excellent coagulation test is the clinical field (i.e. the surgical wound). If there are abnormalities in the coagulation tests without clinical bleeding, a correction is hardly necessary. In patients taking anticoagulant medication, consideration must be given on an individual patient basis, to the relative risks of continuing (bleeding) or stopping (thrombotic events) the medication.
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Jakob, Stephan M., and Jukka Takala. Oxygen transport in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0137.

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Adequate oxygen delivery is crucial for organ survival. The main determinants of oxygen delivery are cardiac output, haemoglobin concentration, and arterial oxygen saturation. The adequacy of oxygen delivery also depends on oxygen consumption, which may vary widely. Mixed venous oxygen saturation reflects the amount of oxygen not extracted by the tissues, and therefore provides useful information on the relationship between oxygen delivery and oxygen needs. If not in balance, tissue hypoxia may ensue and arterial lactate concentration increases. This occurs at higher oxygen delivery rates in acute compared with chronic diseases where metabolic adaptions often occur. Arterial and mixed venous oxygen saturation are related to each other. The influence of mixed venous saturation on arterial saturation increases with an increasing intrapulmonary shunt. This chapter discusses interactions between the components of oxygen transport and how they can be evaluated. Various methods for measuring tissue oxygenation and oxygen consumption are also presented, together with their limitations.
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Ho, Kwok M. Kidney and acid–base physiology in anaesthetic practice. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0005.

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Anatomically the kidney consists of the cortex, medulla, and renal pelvis. The kidneys have approximately 2 million nephrons and receive 20% of the resting cardiac output making the kidneys the richest blood flow per gram of tissue in the body. A high blood and plasma flow to the kidneys is essential for the generation of a large amount of glomerular filtrate, up to 125 ml min−1, to regulate the fluid and electrolyte balance of the body. The kidneys also have many other important physiological functions, including excretion of metabolic wastes or toxins, regulation of blood volume and pressure, and also production and metabolism of many hormones. Although plasma creatinine concentration has been frequently used to estimate glomerular filtration rate by the Modification of Diet in Renal Disease (MDRD) equation in stable chronic kidney diseases, the MDRD equation has limitations and does not reflect glomerular filtration rate accurately in healthy individuals or patients with acute kidney injury. An optimal acid–base environment is essential for many body functions, including haemoglobin–oxygen dissociation, transcellular shift of electrolytes, membrane excitability, function of many enzymes, and energy production. Based on the concepts of electrochemical neutrality, law of conservation of mass, and law of mass action, according to Stewart’s approach, hydrogen ion concentration is determined by three independent variables: (1) carbon dioxide tension, (2) total concentrations of weak acids such as albumin and phosphate, and (3) strong ion difference, also known as SID. It is important to understand that the main advantage of Stewart over the bicarbonate-centred approach is in the interpretation of metabolic acidosis.
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Joynt, Gavin M., and Gordon Y. S. Choi. Blood gas analysis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0072.

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Arterial blood gases allow the assessment of patient oxygenation, ventilation, and acid-base status. Blood gas machines directly measure pH, and the partial pressures of carbon dioxide (PaCO2) and oxygen (PaO2) dissolved in arterial blood. Oxygenation is assessed by measuring PaO2 and arterial blood oxygen saturation (SaO2) in the context of the inspired oxygen and haemoglobin concentration, and the oxyhaemoglobin dissociation curve. Causes of arterial hypoxaemia may often be elucidated by determining the alveolar–arterial oxygen gradient. Ventilation is assessed by measuring the PaCO2 in the context of systemic acid-base balance. A rise in PaCO2 indicates alveolar hypoventilation, while a decrease indicates alveolar hyperventilation. Given the requirement to maintain a normal pH, functioning homeostatic mechanisms result in metabolic acidosis, triggering a compensatory hyperventilation, while metabolic alkalosis triggers a compensatory reduction in ventilation. Similarly, when primary alveolar hypoventilation generates a respiratory acidosis, it results in a compensatory increase in serum bicarbonate that is achieved in part by kidney bicarbonate retention. In the same way, respiratory alkalosis induces kidney bicarbonate loss. Acid-base assessment requires the integration of clinical findings and a systematic interpretation of arterial blood gas parameters. In clinical use, traditional acid-base interpretation rules based on the bicarbonate buffer system or standard base excess estimations and the interpretation of the anion gap, are substantially equivalent to the physicochemical method of Stewart, and are generally easier to use at the bedside. The Stewart method may have advantages in accurately explaining certain physiological and pathological acid base problems.
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Book chapters on the topic "Haemoglobin concentration"

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Jones, Geoffrey, Neil T. Clancy, Simon Arridge, Daniel S. Elson, and Danail Stoyanov. "Inference of Tissue Haemoglobin Concentration from Stereo RGB." In Lecture Notes in Computer Science, 50–58. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43775-0_5.

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Wolf, M., P. Evans, H. U. Bucher, V. Dietz, M. Keel, R. Strebel, and K. von Siebenthal. "Measurement of Absolute Cerebral Haemoglobin Concentration in Adults and Neonates." In Advances in Experimental Medicine and Biology, 219–27. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5399-1_31.

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Jones, Geoffrey, Neil T. Clancy, Xiaofei Du, Maria Robu, Simon Arridge, Daniel S. Elson, and Danail Stoyanov. "Fast Estimation of Haemoglobin Concentration in Tissue Via Wavelet Decomposition." In Lecture Notes in Computer Science, 100–108. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66185-8_12.

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Steimers, André, M. Gramer, M. Takagaki, R. Graf, U. Lindauer, and Matthias Kohl-Bareis. "Simultaneous Imaging of Cortical Blood Flow and Haemoglobin Concentration with LASCA and RGB Reflectometry." In Oxygen Transport to Tissue XXXV, 427–33. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7411-1_57.

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Gao, Lei, Clare E. ElwellElwell, Matthias Kohl-Bareis, Marcus Gramer, Chris E. Cooper, Terence S. Leung, and Ilias Tachtsidis. "Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre." In Oxygen Transport to Tissue XXXII, 15–20. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-7756-4_3.

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Wolf, M., H. U. Bucher, V. Dietz, M. Keel, K. von Siebenthal, and G. Duc. "How to Evaluate Slow Oxygenation Changes to Estimate Absolute Cerebral Haemoglobin Concentration by Near Infrared Spectrophotometry in Neonates." In Advances in Experimental Medicine and Biology, 495–501. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5865-1_62.

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Wolf, M., M. Keel, D. Schenk, V. Dietz, K. von Siebenthal, U. Wolf, O. Baenziger, and H. U. Bucher. "Comparison of Absolute Cerebral Haemoglobin Concentration in Neonates Measured Directly and by the Oxygen Swing Method both Based on Near Infrared Spectrophotometry." In Oxygen Transport to Tissue XX, 125–29. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4863-8_15.

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Nikinmaa, M., and R. G. Boutilier. "Adrenergic Control of Red Cell pH, Organic Phosphate Concentrations and Haemoglobin Function in Teleost Fish." In Mechanisms of Systemic Regulation, 107–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79666-1_5.

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Perry, David J., and Katharine Lowndes. "Blood disorders specific to pregnancy." In Oxford Textbook of Medicine, 2173–80. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.1416.

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Plasma volume increases by more during pregnancy than does red cell mass, leading to haemodilution and a fall in the haematocrit from about 40% to 33%, with the nadir usually reached at 24 to 32 weeks gestation. Anaemia during pregnancy is defined as a haemoglobin concentration of <10.5 g/dl during the second and third trimesters....
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Ciurea, Stefan O., and Ronald Hoffman. "The polycythaemias." In Oxford Textbook of Medicine, 4264–74. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.220308.

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Polycythaemia or erythrocytosis is characterized by an abnormal increase in the numbers of red blood cells, leading to an elevation in the haemoglobin concentration and haematocrit (>52% in men and >48% in women). The cause may be either (1) primary—due to an intrinsic defect of haemopoietic stem cells; or (2) secondary—due to extrinsic stimulation of progenitor erythroid cells by circulating growth factors; and the condition needs to be distinguished from (3) pseudopolycythaemia—in which haematocrit is raised because the plasma volume is decreased....
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Conference papers on the topic "Haemoglobin concentration"

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Zakaria, Hasballah, and Raditya Artha Rochmanto. "Optimum Wavelengths on Haemoglobin Concentration Measurement." In 2018 International Symposium on Electronics and Smart Devices (ISESD). IEEE, 2018. http://dx.doi.org/10.1109/isesd.2018.8605439.

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Steimers, A., M. Gramer, B. Ebert, M. Füchtemeier, G. Royl, C. Leithner, J. P. Dreier, U. Lindauer, and M. Kohl-Bareis. "Imaging of Cortical Haemoglobin Concentration with RGB Reflectometry." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/ecbo.2009.7368_13.

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Steimers, A., M. Gramer, B. Ebert, M. Füchtemeier, G. Royl, C. Leithner, J. P. Dreier, U. Lindauer, and M. Kohl-Bareis. "Imaging of cortical haemoglobin concentration with RGB reflectometry." In European Conferences on Biomedical Optics, edited by Irene Georgakoudi, Jürgen Popp, and Katarina Svanberg. SPIE, 2009. http://dx.doi.org/10.1117/12.831583.

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Shovlin, Claire, Basel Chamali, Vatshalan Santhirapala, Hannah Tighe, and James Jackson. "Arterial oxygen content primarily reflects haemoglobin concentration in a cohort of hypoxaemic patients." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2269.

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Sakaguchi, K., S. Furukawa, E. Okada, T. Katsura, A. Maki, and H. Kawaguchi. "Path length correction for haemoglobin concentration measurement in exposed cortex by multi-spectral imaging." In Biomedical Topical Meeting. Washington, D.C.: OSA, 2006. http://dx.doi.org/10.1364/bio.2006.tui12.

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Sakaguchi, Koichiro, Tomoya Tachibana, Kentaro Yokoyama, Shunsuke Furukawa, Eiji Okada, Takushige Katsura, Atsushi Maki, and Hideo Kawaguchi. "Estimation of Path Length Factor for Measurement of Haemoglobin Concentration in the Exposed Cortical Tissue." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2005. http://dx.doi.org/10.1364/ecbo.2005.wh4.

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Sakaguchi, K., T. Tachibana, K. Yokoyama, S. Furukawa, T. Katsura, A. Maki, H. Kawaguchi, and E. Okada. "Estimation of path length factor for measurement of haemoglobin concentration in the exposed cortical tissue." In European Conference on Biomedical Optics 2005, edited by Kai Licha and Rinaldo Cubeddu. SPIE, 2005. http://dx.doi.org/10.1117/12.632848.

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Sakaguchi, Koichiro, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, and Eiji Okada. "Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2007. http://dx.doi.org/10.1364/ecbo.2007.6629_19.

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Plywaczewski, Robert, Barbara Kazanecka, Dorota Gorecka, and Pawel Sliwinski. "Plasma Haemoglobin A1c (HbA1c) Concentration And Cardiovascular Complications In Obstructive Sleep Apnoea (OSA) Patients With And Without Diabetes." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3696.

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Sakaguchi, Koichiro, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, and Eiji Okada. "Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis." In European Conference on Biomedical Optics, edited by Brian W. Pogue and Rinaldo Cubeddu. SPIE, 2007. http://dx.doi.org/10.1117/12.728225.

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