Relevant bibliographies by topics / Haematopoietic

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Haematopoietic'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Haematopoietic.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Haematopoietic"

1

Kondera, Elżbieta. "Haematopoiesis and haematopoietic organs in fish." Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego 15, no. 1 (March 31, 2019): 9–16. http://dx.doi.org/10.5604/01.3001.0013.4535.

Full text
Abstract:
Haematopoiesis is a complex process in which haematopoietic stem cells, the most immature elements of the haematopoietic hierarchy, proliferate and differentiate into various classes of haematopoietic progenitor cells. These progenitor cells have been shown to be able to differentiate into mature blood cells: erythrocytes, lymphocytes, thrombocytes, granulocytes, and monocytes. The pronephros, or head kidney, is a basic organ forming the blood elements, and is also a reservoir of blood cells. Basic haematopoietic structures and mechanisms in fish are similar to those functioning in other vertebrates, and all haematopoietic cell types are very similar to those of mammals.
APA, Harvard, Vancouver, ISO, and other styles
2

De, Ranita, Kulkarni Uday Prakash, and Eunice S. Edison. "Complex Interactions in Regulation of Haematopoiesis—An Unexplored Iron Mine." Genes 12, no. 8 (August 20, 2021): 1270. http://dx.doi.org/10.3390/genes12081270.

Full text
Abstract:
Iron is one of the most abundant metals on earth and is vital for the growth and survival of life forms. It is crucial for the functioning of plants and animals as it is an integral component of the photosynthetic apparatus and innumerable proteins and enzymes. It plays a pivotal role in haematopoiesis and affects the development and differentiation of different haematopoietic lineages, apart from its obvious necessity in erythropoiesis. A large amount of iron stores in humans is diverted towards the latter process, as iron is an indispensable component of haemoglobin. This review summarises the important players of iron metabolism and homeostasis that have been discovered in recent years and highlights the overall significance of iron in haematopoiesis. Its role in maintenance of haematopoietic stem cells, influence on differentiation of varied haematopoietic lineages and consequences of iron deficiency/overloading on development and maturation of different groups of haematopoietic cells have been discussed.
APA, Harvard, Vancouver, ISO, and other styles
3

Štefková, Kateřina, Markéta Hanáčková, Jan Kučera, Katarzyna Anna Radaszkiewicz, Barbora Ambrůžová, Lukáš Kubala, and Jiří Pacherník. "MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells." Stem Cells International 2019 (June 2, 2019): 1–16. http://dx.doi.org/10.1155/2019/5128135.

Full text
Abstract:
The activation of p38alpha kinase mediates cell response to various extracellular factors including many interleukins and growth factors important for haematopoiesis. The role of p38alpha kinase was previously analysed in particular haematopoietic cells. In this study and for the first time, the role of p38alpha kinase in haematopoiesis was studied using a model of continuous haematopoietic development in pluripotent embryonic stem cellsin vitro. The expression of transcripts associated with haematopoiesis and the potential for the formation of specific haematopoietic cell colonies were compared between wild-type and mutant p38alpha gene-depleted cells. The absence of p38alpha kinase led to the inhibition of hemangioblast formation during the first step of haematopoiesis. Later, during differentiation, due to the lack of p38alpha kinase, erythrocyte maturation was impaired. Mutant p38α−/−cells also exhibited decreased potential with respect to the expansion of granulocyte colony-forming units. This effect was reversed in the absence of erythropoietin as shown by colony-forming unit assay in media for colony-forming unit granulocytes/macrophages. p38alpha kinase thus plays an important role in the differentiation of common myeloid precursor cells into granulocyte lineages.
APA, Harvard, Vancouver, ISO, and other styles
4

Basden, K., DW Cooper, and EM Deane. "Development of the blood-forming tissues of the tammar wallaby Macropus eugenii." Reproduction, Fertility and Development 8, no. 6 (1996): 989. http://dx.doi.org/10.1071/rd9960989.

Full text
Abstract:
The development of the haematopoietic tissues of the tammar wallaby Macropus eugenii follows a similar pattern to that observed in eutherian and other metatherian mammals. At birth, the liver appears to be the only site of haematopoiesis with significant numbers of neutrophils and stem cells present in the circulation. By Day 3, the spleen shows limited haematopoietic activity and by Day 12 contains areas of erythroid and myeloid cells. At two weeks after birth, the haematopoetic activity in the liver declines and small areas of haematopoiesis are apparent in the bone marrow. By the end of the first month, the bone marrow appears to be the major site of haematopoiesis.
APA, Harvard, Vancouver, ISO, and other styles
5

Al-Drees, Mohammad A., Jia Hao Yeo, Badwi B. Boumelhem, Veronica I. Antas, Kurt W. L. Brigden, Chanukya K. Colonne, and Stuart T. Fraser. "Making Blood: The Haematopoietic Niche throughout Ontogeny." Stem Cells International 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/571893.

Full text
Abstract:
Approximately one-quarter of all cells in the adult human body are blood cells. The haematopoietic system is therefore massive in scale and requires exquisite regulation to be maintained under homeostatic conditions. It must also be able to respond when needed, such as during infection or following blood loss, to produce more blood cells. Supporting cells serve to maintain haematopoietic stem and progenitor cells during homeostatic and pathological conditions. This coalition of supportive cell types, organised in specific tissues, is termed the haematopoietic niche. Haematopoietic stem and progenitor cells are generated in a number of distinct locations during mammalian embryogenesis. These stem and progenitor cells migrate to a variety of anatomical locations through the conceptus until finally homing to the bone marrow shortly before birth. Under stress, extramedullary haematopoiesis can take place in regions that are typically lacking in blood-producing activity. Our aim in this review is to examine blood production throughout the embryo and adult, under normal and pathological conditions, to identify commonalities and distinctions between each niche. A clearer understanding of the mechanism underlying each haematopoietic niche can be applied to improvingex vivocultures of haematopoietic stem cells and potentially lead to new directions for transplantation medicine.
APA, Harvard, Vancouver, ISO, and other styles
6

Vainieri, Maria L., Andrew M. Blagborough, Adam L. MacLean, Myriam L. R. Haltalli, Nicola Ruivo, Helen A. Fletcher, Michael P. H. Stumpf, Robert E. Sinden, and Cristina Lo Celso. "Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points." Open Biology 6, no. 6 (June 2016): 160038. http://dx.doi.org/10.1098/rsob.160038.

Full text
Abstract:
Haematopoiesis is the complex developmental process that maintains the turnover of all blood cell lineages. It critically depends on the correct functioning of rare, quiescent haematopoietic stem cells (HSCs) and more numerous, HSC-derived, highly proliferative and differentiating haematopoietic progenitor cells (HPCs). Infection is known to affect HSCs, with severe and chronic inflammatory stimuli leading to stem cell pool depletion, while acute, non-lethal infections exert transient and even potentiating effects. Both whether this paradigm applies to all infections and whether the HSC response is the dominant driver of the changes observed during stressed haematopoiesis remain open questions. We use a mouse model of malaria, based on natural, sporozoite-driven Plasmodium berghei infection, as an experimental platform to gain a global view of haematopoietic perturbations during infection progression. We observe coordinated responses by the most primitive HSCs and multiple HPCs, some starting before blood parasitaemia is detected. We show that, despite highly variable inter-host responses, primitive HSCs become highly proliferative, but mathematical modelling suggests that this alone is not sufficient to significantly impact the whole haematopoietic cascade. We observe that the dramatic expansion of Sca-1 + progenitors results from combined proliferation of direct HSC progeny and phenotypic changes in downstream populations. We observe that the simultaneous perturbation of HSC/HPC population dynamics is coupled with early signs of anaemia onset. Our data uncover a complex relationship between Plasmodium and its host's haematopoiesis and raise the question whether the variable responses observed may affect the outcome of the infection itself and its long-term consequences on the host.
APA, Harvard, Vancouver, ISO, and other styles
7

Haznedaroglu, Ibrahim C., and Yavuz Beyazit. "Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis." Clinical Science 124, no. 5 (November 12, 2012): 307–23. http://dx.doi.org/10.1042/cs20120300.

Full text
Abstract:
The locally active ligand peptides, mediators, receptors and signalling pathways of the haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin–angiotensin system) affect the essential steps of definitive blood cell production. Haematopoiesis, erythropoiesis, myelopoiesis, formation of monocytic and lymphocytic lineages, thrombopoiesis and other stromal cellular elements are regulated by the local BM RAS. The local BM RAS is present and active even in primitive embryonic haematopoiesis. ACE (angiotensin-converting enzyme) is expressed on the surface of the first endothelial and haematopoietic cells, forming the marrow cavity in the embryo. ACE marks early haematopoietic precursor cells and long-term blood-forming CD34+ BM cells. The local autocrine tissue BM RAS may also be active in neoplastic haematopoiesis. Critical RAS mediators such as renin, ACE, AngII (angiotensin II) and angiotensinogen have been identified in leukaemic blast cells. The local tissue RAS influences tumour growth and metastases in an autocrine and paracrine fashion via the modulation of numerous carcinogenic events, such as angiogenesis, apoptosis, cellular proliferation, immune responses, cell signalling and extracellular matrix formation. The aim of the present review is to outline the known functions of the local BM RAS within the context of primitive, definitive and neoplastic haematopoiesis. Targeting the actions of local RAS molecules could represent a valuable therapeutic option for the management of neoplastic disorders.
APA, Harvard, Vancouver, ISO, and other styles
8

Keenan, Christine R. "Heterochromatin and Polycomb as regulators of haematopoiesis." Biochemical Society Transactions 49, no. 2 (April 30, 2021): 805–14. http://dx.doi.org/10.1042/bst20200737.

Full text
Abstract:
Haematopoiesis is the process by which multipotent haematopoietic stem cells are transformed into each and every type of terminally differentiated blood cell. Epigenetic silencing is critical for this process by regulating the transcription of cell-cycle genes critical for self-renewal and differentiation, as well as restricting alternative fate genes to allow lineage commitment and appropriate differentiation. There are two distinct forms of transcriptionally repressed chromatin: H3K9me3-marked heterochromatin and H3K27me3/H2AK119ub1-marked Polycomb (often referred to as facultative heterochromatin). This review will discuss the role of these distinct epigenetic silencing mechanisms in regulating normal haematopoiesis, how these contribute to age-related haematopoietic dysfunction, and the rationale for therapeutic targeting of these pathways in the treatment of haematological malignancies.
APA, Harvard, Vancouver, ISO, and other styles
9

HARMS, Gesche, Regine KRAFT, Gerlinde GRELLE, Bärbel VOLZ, Jens DERNEDDE, and Rudolf TAUBER. "Identification of nucleolin as a new L-selectin ligand." Biochemical Journal 360, no. 3 (December 10, 2001): 531–38. http://dx.doi.org/10.1042/bj3600531.

Full text
Abstract:
Apart from leucocyte–endothelial interactions, the adhesion molecule L-selectin mediates the homotypic adhesion of leucocytes during recruitment at sites of acute inflammation, as well as intercellular adhesion of haematopoietic progenitor cells during haematopoiesis. There is evidence that, in addition to P-selectin glycoprotein ligand-1, other as-yet-unidentified proteins function as L-selectin ligands on human leucocytes and haematopoietic progenitor cells. In the present study, we show: (i) by affinity chromatography on L-selectin–agarose; (ii) by protein identification using MS; and (iii) by covalent cell-surface labelling with sulphosuccinimidyl-2-(biotinamido)ethyl-1,3-dithiopropionate that the multifunctional nuclear protein nucleolin is partly exposed on the cell surface, and is a ligand of L-selectin in human leucocytes and haematopoietic progenitor cells.
APA, Harvard, Vancouver, ISO, and other styles
10

Karia, Dimple, Robert C. G. Gilbert, Antonio J. Biasutto, Catherine Porcher, and Erika J. Mancini. "The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain." Royal Society Open Science 7, no. 1 (January 2020): 191048. http://dx.doi.org/10.1098/rsos.191048.

Full text
Abstract:
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes result in tightly regulated cell differentiation transcriptional programmes. However, the complex functional and physical interplay between transcription factors and chromatin-modifying enzymes remains elusive. Recent evidence has implicated histone demethylases in normal haematopoietic differentiation as well as in malignant haematopoiesis. Here, we report an interaction between H3K4 demethylase JARID1A and the haematopoietic-specific master transcription proteins SCL and GATA1 in red blood cells. Specifically, we observe a direct physical contact between GATA1 and the second PHD domain of JARID1A. This interaction has potential implications for normal and malignant haematopoiesis.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Haematopoietic"

1

Robinson, Simon N. "Proliferation regulation of haematopoietic stem cells in normal and leukaemic haematopoiesis." Thesis, University of St Andrews, 1992. http://hdl.handle.net/10023/14965.

Full text
Abstract:
The cellular integrity of the blood is maintained by the cellular output of the haematopoietic stem cell population which produces the specialized precursors and differentiated cells which constitute the blood. The investigation of haematopoietic stem cell behaviour and regulation has been hampered by both the difficulty in their identification and the development of relevant assay systems. The purpose of this investigation was to study the behaviour and regulation of the haematopoietic stem cell population in normal and leukaemic haematopoiesis using an in vitro assay of a primitive haematopoietic precursor. The use of a combination of haematopoietic colony-stimulating factors [interleukin 3 (IL3)/multi-CSF and macrophage colony-stimulating factor (M-CSF/CSF-1)] in semi-solid agar culture of murine haematopoietic tissue, stimulated the proliferation of a haematopoietic colony-forming cell, defined as the "HPP-CFCIL3+CSF-1" population, which was characterized by a high proliferative potential, a multipotency and behavioural and regulatory properties consistent with its being a primitive haematopoietic precursor and possibly a component of the haematopoietic stem cell population. The proportion of the in vitro HPP-CFCIL3+csf-1 population in S-phase in normal murine marrow, was determined to be relatively low at approximately 10%, increasing to approximately 40% in sublethally X-irradiated, regenerating murine marrow and the respective presence of the haematopoietic stem cell proliferation inhibitor and stimulator was demonstrable by the induction of appropriate kinetic changes in the in vitro HPP-CFCIL3+CSF-1 population. In leukaemic haematopoiesis, leukaemic proliferation often occurs at the expense of apparently suppressed normal haematopoiesis. In vitro HPP-CFCIL3+CSF-1 assay of the haematopoietic stem cell proliferation regulators in a number of murine, myeloid leukaemic cell lines, failed to demonstrate either increased levels of the haematopoietic stem cell proliferation inhibitor, or evidence of a direct-acting, leukaemia- associated proliferation inhibitor, however, evidence of a leukaemia- associated impairment of inhibitor and stimulator production was observed and this may be a possible mechanism by which the leukaemic population develops a proliferative advantage over normal haematopoietic tissue. The identification of a possible mechanism of leukaemic progression and suppression of normal haematopoiesis may subsequently allow the development of potentially more effective disease treatment and management regimes. The endogenous haemoregulatory tetrapeptide: Acetyl-N-Ser- Asp-Lys-Pro [AcSDKP, Mr=487 amu] is reported to prevent the G0-G1 transition of haematopoietic stem cells into S-phase. The mechanism of action of AcSDKP and a number of related peptides, was investigated in relation to the stem cell proliferation stimulator and inhibitor. AcSDKP demonstrated no direct haemoregulatory role against the in vitro HPP-CFCIL3+CSF-1 population, which is consistent with reports that AcSDKP is not active against cells already in late G1, or S-phase, rather it appeared to act indirectly by impairing the capacity of the haematopoietic stem cell proliferation stimulator to increase the proportion of the in vitro HPP-CFCIL3+CSF-1 population in S-phase. An apparent impairment of stimulator action may explain the reported AcSDKP-associated 'block' of haematopoietic stem cell recruitment. A putative endogenous AcSDKP precursor and synthetic and degradative enzyme systems have been reported and the possible physiopathological role of AcSDKP in a number of myeloproliferative disorders has been implicated. The potential application of AcSDKP as a 'haemoprotective' agent administered prior to the use of S-phase- specific chemotherapy may be of clinical significance. The in vitro HPP-CFCIL3+CSF-1 assay of a primitive haematopoietic precursor cell population, which may be a component of the haematopoietic stem cell population, should play a significant role in the investigation of haematopoietic stem cell behaviour and regulation in both normal and aberrant haematopoiesis. With the characterization of the mechanism(s) of action of the haematopoietic stem cell proliferation inhibitor and stimulator and the haemoregulatory tetrapeptide AcSDKP, the manipulation of the haematopoietic system to clinical advantage can be envisaged, while the identification of the aberrant regulatory mechanism(s) in haematopoietic dysfunction may allow, the development of more effective disease treatment and management regimes.
APA, Harvard, Vancouver, ISO, and other styles
2

Samitsch, Marina. "Dissecting human haematopoietic progenitors." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:58511f8d-cb36-4acf-b706-c465c50f5404.

Full text
Abstract:
Human haematopoiesis resembles a complex hierarchy, however most intermediate stages are only poorly defined. Efforts to characterise human progenitors have been inconsistent and failed to integrate previous knowledge. Furthermore, characterisation of normal progenitors has important implications in acute myeloid leukaemia (AML) biology. We previously established that leukaemic stem cells (LSCs) resemble the immunophenotypic progenitor compartments more closely than the stem cell fraction. Therefore, I set out to characterise human stem and progenitor cells (HSCPs) on phenotypic, molecular and functional level to complete the picture of human haematopoiesis. I purified HSPCs based on their immunophenotype from adult bone marrow (BM) and umbilical cord blood (CB) to investigate steady state and neonatal haematopoiesis. To define differentiation potentials, HSPCs were subjected to functional in vitro assays on bulk and clonal level. Limit dilution assays were used to determine the frequency of cells with multiple differentiation potentials. RNA sequencing revealed underlying lineage priming and specific gene expression signatures. I successfully characterized the incompletely defined Lin-CD34+CD38-CD45RA+ fraction in BM and CB, containing a CD10lo lymphoid-primed multipotent progenitor (LMPP) with T cell, B cell, NK cell, granulocytic and monocytic differentiation potential, and succeeded in placing it in the haematopoietic hierarchy with relation to similar lympho-myeloid progenitors defined by other groups. This research lays the foundation to characterise early human progenitors with a comprehensive toolkit on a phenotypic, molecular and functional level. Findings from this thesis might provide knowledge about potential targets in LSCs.
APA, Harvard, Vancouver, ISO, and other styles
3

Bureau, Emilie Aurelie. "Investigation of the role of haematopoietic cell kinase in normal and leukaemic haematopoiesis." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444125/.

Full text
Abstract:
Acute myeloid leukaemia (AML) is characterised by an accumulation of immature blasts that fail to fully differentiate. Leukaemia is organised as a hierarchy, which is maintained by leukaemic stem cells (LSC). To identify molecular differences between normal haematopoietic stem cells (HSC) and LSC, we performed microarray analysis and found that haematopoietic cell kinase (HCK) is overexpressed in LSC. Thus, by knocking-down HCK in leukaemic cells or overexpressing it in stem cell enriched fractions, we should be able to evaluate its role in leukaemogenesis. Since LSC are difficult to culture in vitro, we started to validate HCK silencing in leukaemic cell lines, Mono-mac-6 (MM6), U937 and Fujioka/P31, which highly express HCK. In all cell lines studied, no more than 50% silencing could be achieved, even when a short-hairpin anti-HCK was cloned into a lentiviral backbone to follow the long-term effect of HCK silencing. Decrease in kinase activity was confirmed using kinase assay and phospho-specific antibody recognising the activated HCK kinase. We show that HCK silencing does not affect the cell cycle, proliferation, differentiation or apoptosis of the cell lines. However, using methylcellulose assay, we observe a significant change in MM6 colony morphology caused by a decrease in their migration properties. Moreover, using phospho-flow cytometry, G-CSF and GM-CSF signal transduction towards STAT5 could be proven to occur via HCK in MM6, but not in Fujioka/P31 or U937 cells. HSC enriched umbilical cord blood cells were also transduced with a lentivirus encoding p59HCK. Overexpression of p59HCK in these cells led to their enhanced erythroid differentiation at the expense of myeloid differentiation underlined by the activation of c-Raf, ERK and STATS. Overall, this study can be used as a preliminary set up for further investigation of the role of HCK in normal human stem cells and in primary AML samples in vivo.
APA, Harvard, Vancouver, ISO, and other styles
4

Ivanovs, Andrejs. "Development of haematopoietic stem cells in the human embryo." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8839.

Full text
Abstract:
Haematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Qualitative and quantitative assessment of HSCs can only be performed functionally using the in vivo long-term repopulation assay. Due to the lack of such data, little is known about the development of HSCs in the human embryo, which is a prerequisite for the development of new therapeutic strategies. Employing the xenotransplantation assay, I have performed here the spatio-temporal mapping of HSC activity within the human embryo and have shown that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the ventral wall of the dorsal aorta, and only later appear in the yolk sac, liver and placenta. Human AGM region HSCs transplanted into immunodeficient mice provide long-term high-level multilineage haematopoietic repopulation. These cells, although present in the AGM region in low numbers, exhibit a very high self-renewal potential. A single HSC derived from the AGM region generates around 600 daughter HSCs in primary recipient mice, which disseminate throughout the entire recipient bone marrow and are retransplantable. These findings highlight the vast regenerative potential of the earliest human HSCs and set a new standard for in vitro generation of HSCs from pluripotent stem cells for the purpose of regenerative medicine. I have also established a preliminary immunophenotype of the earliest human HSC. These data will be useful for my future studies on the mechanisms underlying the high potency of human embryonic HSCs and on the characterisation of embryonic HSC niche.
APA, Harvard, Vancouver, ISO, and other styles
5

Rossouw, Sophia Catherine. "Apoptosis in Haematopoietic progenitors." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3179.

Full text
Abstract:
Introduction: Intracranial pressure (ICP) monitoring is a cornerstone of care for patients with severe traumatic brain injury (TBI). The primary goal of ICP treatment is to preserve brain oxygenation, and since brain oxygenation is usually not measured, the control of ICP is used as a surrogate marker. However studies indicating that cerebral hypoxia/ischemia may occur in the face of adequate ICP and cerebral perfusion pressure (CPP) suggest that the interaction between ICP and brain oxygenation is poorly understood and warrants further investigation. This is of particular importance in the context of children in whom the interpretation of relationships between intracranial factors is even more complex due to changing physiological norms with age. To date little scientific data exists in children and treatment threshold values are often extrapolated from adult guidelines. This study aims to better understand the relationship between ICP and brain oxygenation measured as brain tissue oxygen tension (PbtO2) in a large paediatric cohort suffering from severe TBI. Specifically analysis 1) investigated ICP and PbtO2 profiles over time following TBI, 2) examined the relationship between ICP and PbtO2 from time-linked paired observations, 3) explored various critical thresholds for ICP and PbtO2, and 4) interrogated digital data trends depicting the relationship between ICP and PbtO2. The level of agreement between hourly recorded and high frequency electronic data for ICP and PbtO2 was also evaluated. Method: Paired ICP and PbtO2 data from 75 children with severe TBI were tested with correlation and regression. Additional analyses controlled for mean arterial pressure (MAP), arterial partial pressure of oxygen (PaO2), CPP, arterial partial pressure of carbon dioxide (PaCO2) and haemoglobin (Hb) using multivariate logistic regression analysis and general estimating equations. Various thresholds for ICP were examined; these included age-related thresholds to account for the potential influence of age. Receiver-operating curves (ROCs) were used to graphically demonstrate the relationships between various thresholds of ICP and various definitions of low PbtO2. These were constructed for pooled and individual patient data. Interrogation of electronically recorded data allowed for case illustrations examining the relationship between ICP and PbtO2 at selected time points. Hourly and electronic data were compared using Bland and Altman plots and by contrasting the frequency of ICP and PbtO2 perturbations recorded with each system. 5 Result: Analyses using over 8300 hours of paired observations revealed a weak relationship between ICP and PbtO2, with an initially positive but weak slope (r = 0.05) that trended downwards only at higher values of ICP. Controlling for inter-individual differences, as well as MAP, CPP, PaO2, PaCO2 and Hb did not strengthen this association. This poor relationship was further reflected in the examination of threshold ICP values with ROCs, no singular critical ICP threshold for compromised brain oxygenation was discernible. Using age-based thresholds did not improve this relationship and individual patient ROCs demonstrated inter-individual heterogeneity in the relationship between ICP and PbtO2. However, it was clear that in individual patients ICP did exhibit a strong negative relationship with PbtO2 at particular time points, but various different relationships between the 2 variables were also demonstrated. A high level of agreement was found between hourly and electronic data. Conclusion: These results suggest that the relationship between ICP and PbtO2 is highly complex. Although the relationship in individual children at specific time points may be strong, pooled data for the entire cohort of patients, and even for individual patients, suggest only a weak relationship. This is likely because several other factors affect PbtO2 outside of ICP, and some factors affect both independently of each other. These results suggest that more study should be directed at optimising ICP thresholds for treatment in children. The use of complimentary monitoring modalities may assist in this task. Depending on the adequacy of measures of brain perfusion, metabolism or oxygenation, it is possible that targeting a range of ICP values in individual patients may be appropriate; however this would require detailed investigation.
APA, Harvard, Vancouver, ISO, and other styles
6

Stocking, Carol E. "Autonomous growth of haematopoietic cells." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290956.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Butler, Lisa H. "Chromosome translocations in haematopoietic neoplasms." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360209.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Trento, Cristina. "Interaction between haematopoietic and mesenchymal stroma." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/37557.

Full text
Abstract:
Parenchyma and stroma represent the functional and structural units in every organ of the body respectively. Stromal cells of mesenchymal origin (MSC) have traditionally been associated with a structural support activity within the tissue, but it is only recently that more complex functions have been unveiled. Subsets of MSC have been shown to play a fundamental role in self-renewal and differentiation of haematopoietic stem cells (HSC). Recent findings show that MSC and bone marrow (BM) macrophages represent fundamental components in the niche, modulating egress and mobilization of HSC during normal or emergency myelopoiesis. Therefore, I have decided to investigate whether and how MSC contribute to the formation and function of myeloid cells. In an in vitro co-culture model I have observed that MSC have the ability to induce the expansion and differentiation of different subsets of mature myeloid cells from haematopoietic BM cells. Based on the differential expression of CD11b and Gr-1, three cell subsets recapitulating myeloid differentiation could be identified. MSC induced differentiation targets common myeloid progenitors (CMP) or granulocyte/macrophage progenitors (GMP) but not the primitive HSC. CD11b+ sorted cells obtained at the end of the co-culture exhibited a functional profile characterised by high levels of both anti- and pro-inflammatory markers, such as nitric oxide synthase 2 (NOS2) and arginase-1 (ARG-1). In order to identify the mechanisms involved in this phenomenon I have chosen to investigate a number of molecules involved in the regulation of haematopoietic differentiation by the microenvironment. I have demonstrated that whilst NOS2 and agrin, an ECM protein, play a key role in the differentiation of CD11b+ Gr-1- F4/80+ cells, complement appears to be primarily involved in the generation of CD11b+ Gr-1int-low F4/80- cells. My studies have shown that MSC differentiating activity is not confined to the BM but can also be detected in MSC from other tissues like skin and kidney. Overall these results suggest a key role for stromal cells as regulators of myeloid differentiation. Further investigation is under way to assess the importance of such a function in vivo.
APA, Harvard, Vancouver, ISO, and other styles
9

Goodman, Reyna Suzanne. "Immunogenetics of haematopoietic stem cell transplantation." Thesis, Anglia Ruskin University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478885.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Wong, Gabriel K. "Haematopoietic clonality in common variable immunodeficiency." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6935/.

Full text
Abstract:
The aetiology of Common Variable Immunodeficiency (CVID) has fascinated immunologists since Dr. Janeway reported the first case in 1953. While the advances in molecular biology have enlightened us on the aetiology in some patients, the majority is not caused by inherited genetic disorders. A convincing mechanism accounting for the intrinsic variable and partial nature of the condition has yet been proposed. CVID separates itself from other primary antibody deficiencies by the procurement of an abnormal T-cell compartment. Data from this study support that both T-cells and B-cells are subjected to similar deficiency. Investigation of the T-cell receptor repertoire by next-generation sequencing and multi-parametric flow cytometry suggests a severe reduction in naïve T-cell output from the thymus. Similarly, the study of long-lived plasma cell generation and survival highlighted the greatest functional deficits in the naïve B-cell pool, altogether supporting an acquired arrest in lymphogenesis. Using DNA methylation as a surrogate marker for pre-VDJ clonality, this study further shows that some CVID patients exhibited clonal haematopoiesis, adjoining CVID to other clonal haematopoiesis related acquired haematological disorders. Further work is being focused on using high resolution techniques to confirm this association and mechanistically define the development of antibody deficiency in adulthood.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Haematopoietic"

1

Stocking, Carol E. Autonomous growth of haematopoietic cells. Uxbridge: Brunel University, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Bertheault-Cvitkovic, F. Breast cancer: The role of haematopoietic growth factors. Macclesfield: Gardiner-Caldwell Communications, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tura, S. Multiple myeloma: The role of haematopoietic growth factors. Macclesfield: Gardiner-Caldwell Communications Ltd., 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Kaye, S. B. Hodgkin's disease: The role of haematopoietic growth factors. Macclesfield: Gardiner-Caldwell Communications, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Hoelzer, D. Myeloid malignancies: The role of haematopoietic growth factors. Macclesfield: Gardiner-Caldwell Communications, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Crowther, D. Non-Hodgkin's lymphoma: The role of haematopoietic growth factors. Macclesfield: Gardiner-Caldwell Communications, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Dexter, T. Michael. Haematopoietic growth factors: Review of biology and clinical potential. Macclesfield: Gardiner-Caldwell Communications, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Neijt, J. P. Advanced ovarian cancer: The role of haematopoietic growth factors. Macclesfield: Gardiner-CaldwellCommunications, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

International Agency for Research on Cancer and World Health Organization, eds. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: International Agency for Research on Cancer, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Barge, A. Acute myeloid leukaemia: The role of haematopoietic growth factors. Macclesfield: Gardner-Caldwell Communications, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Haematopoietic"

1

Taylor, Alice M., and Barbara J. Bain. "The haematopoietic system." In The Biology of Ageing and Its Clinical Implication, 50–64. London: CRC Press, 2022. http://dx.doi.org/10.1201/9781846197925-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Taylor, Ian. "Lymphoid and haematopoietic system." In A Practical Guide to the Histology of the Mouse, 149–68. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118789568.ch9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Baranov, Alexander, Dirk Densow, T. M. Fliedner, and Hauke Kindler. "Haematopoietic Stem Cell Transplantation." In Clinical Pre Computer Proforma for the International Computer Database for Radiation Exposure Case Histories, 93–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78740-9_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Globerson, Amiela. "Haematopoietic Stem Cell Ageing." In Ageing Vulnerability: Causes and Interventions, 85–100. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470868694.ch8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Thain, Colin, and Jacqueline Bloomfield. "Haematopoietic Stem Cell Transplantation." In Cancer and Cancer Care, 217–32. 1 Oliver’s Yard, 55 City Road London EC1Y 1SP: SAGE Publications Ltd, 2015. http://dx.doi.org/10.4135/9781473920620.n14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Rosenthal, F. M., A. Lindemann, F. Herrmann, and R. Mertelsmann. "Interleukins and Haematopoietic Growth Factors." In Lymphohaematopoietic Growth Factors in Cancer Therapy, 3–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-76037-2_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Snowden, John, and Stephen Webber. "Haematopoietic Stem Cell Transplantation (HSCT)." In Haematology in Critical Care, 135–43. Oxford: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118869147.ch21.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Domen, Jos, and Jignesh Dalal. "Haematopoietic Stem Cells in Therapy." In Principles of Stem Cell Biology and Cancer, 65–83. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118670613.ch4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Gordon, M. Y. "Biology of Haematopoietic Stem Cells." In Peripheral Blood Stem Cell Autografts, 26–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-75717-4_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Wilkinson, Adam C., and Berthold Göttgens. "Transcriptional Regulation of Haematopoietic Stem Cells." In Transcriptional and Translational Regulation of Stem Cells, 187–212. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6621-1_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Haematopoietic"

1

Tan, K. K., K. Z. Tang, S. Huang, A. S. Putra, T. H. Lee, S. C. Ng, Jerry K. Y. Chan, L. G. Tan, and Mark S. K. Chong. "Automated haematopoietic stem cells harvesting machine." In 2009 International Conference on Mechatronics and Automation (ICMA). IEEE, 2009. http://dx.doi.org/10.1109/icma.2009.5246304.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Thieffry, Denis. "Logical modelling of haematopoietic cell fate reprogramming." In the 9th International Conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2037509.2037512.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tent, Michiel. "Autologous haematopoietic stem cell transplantation versus DMTs." In ECTRIMS Congress 2022, edited by Hans-Peter Hartung. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/320f3185.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lennon, Jonathon, Ian Bilmon, Megan Hogg, David Gottlieb, and Peter Middleton. "Pulmonary function changes following allogeneic haematopoietic cell transplantation." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa4190.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Tang, K. Z., M. Rauff, H. C. Tan, and Y. Zhou. "Precession-based control methodology for haematopoietic stem cells harvesting." In 2013 10th IEEE International Conference on Control and Automation (ICCA). IEEE, 2013. http://dx.doi.org/10.1109/icca.2013.6565204.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Falade, Funmi, Gulrukh Ahsan, Kimberly C. Gilmour, Fariba Tahami, and Jesmina James. "83 Immune reconstitution of patients with unrelated allogeneic haematopoietic transplants." In GOSH Conference 2019, Care of the Complex Child. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-gosh.83.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Yan, W. W., Y. Liu, and B. M. Fu. "Mechanical Mechanism of Circadian Fluctuations Regulated Haematopoietic Stems Cell Release." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53377.

Full text
Abstract:
Haematopoietic stem cells (HSCs) circulate in the bloodstream under flow conditions, but the mechanical mechanisms of governing their physiological trafficking in mammals are still not yet clearly understood. The mobilization of HSCs and their progenitors into the circulation represents the basis for modern bone marrow transplantation procedures [1]. Recently, Mendez-Ferrer et al. performed experimental investigations on mice [2]. They demonstrated that the circulating HSCs and their progenitors exhibit robust circadian oscillations, and the circadian fluctuations could also be significantly altered when the HSCs were subjected to different time of lighting. These results indicated that the photic cues could affect the trafficking of HSCs in healthy animals. This implies that the light is the stimulus of HSCs release. When the HSCs are exposed to light, the HSCs release would markedly increase; when the HSCs are in darkness, the HSCs release keeps low efficiency. In this study, we numerically simulate this phenomenon to study the mechanical mechanism of circadian fluctuations regulated HSCs release under the influence of periodic lighting time.
APA, Harvard, Vancouver, ISO, and other styles
8

Scheidl, Stefan, Wilma Zinke-Cerwenka, Gabor Kovacs, Sonja Reitter, Natascha Troester, and Horst Olschewski. "Bronchiolitis Obliterans In Allogeneic Haematopoietic Stem Cell Transplantation Following Nonmyeloablative Conditioning." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sanchez, M., JM Ortgega, L. Calvo, N. Gomez, I. Navarro, and C. Abarca. "CP-010 Use and effectiveness of plerixafor for haematopoietic stem cells mobilisation." In 22nd EAHP Congress 22–24 March 2017 Cannes, France. British Medical Journal Publishing Group, 2017. http://dx.doi.org/10.1136/ejhpharm-2017-000640.10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Du Chunjuan and Zeng Yanjun. "Hidden Markov Model Analysis of Motifs in interleukins and haematopoietic growth factor family." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1615882.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Haematopoietic"

1

Hristova, Marina, Plamen Todorov, Nadya Petrova, Diana Gulenova, Ibryam Ibryam, and Elena Hristova. Clonogenic Activity of Human Haematopoietic Stem Cells Cultured under Micro-vibrations. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, May 2018. http://dx.doi.org/10.7546/crabs.2018.04.08.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Haematopoietic' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography