Journal articles: 'Gynura procumbens'

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Selviani, Amalia, Sugito Sugito, and Sutriswanto Sutriswanto. "Pengaruh Variasi Konsentrasi Ekstrak Daun Sambung Nyawa terhadap Zona Hambat Bakteri Escherichia Coli Metode Difusi." Jurnal Laboratorium Khatulistiwa 2, no. 2 (July 7, 2019): 44. http://dx.doi.org/10.30602/jlk.v2i2.328.

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Abstract: Gynura procumbens plants or often called Gynura procumbens (Lour.) Merr is a plant belonging to the Asteraceae family. Based on the results of phytochemical screening performed, the chemical content contained in the leaves of Gynura procumbens (Lour).Merr is phenol, saponin and steroid. Phenol and saponin each have a mechanism as an antibacterial. The purpose of this study was to determine the inhibition zone of Gynura procumbens extract, concentration of 10%, 20%, 30%, 40% dan 50% to Escherichia coli bacteria on hook moutellic agar and to know the value of Resistant, Intermediate and Sensitive from leaf extract of Gynura procumbens (Lour).Merr against bacterial inhibition zone of Escherichia coli, as well as to analyze the effect of concentration variation of Gynura procumbens (Lour).Merr leaf extract to the inhibitory zone of Escherichia coli bacteria. The research method used is experimental method. Based on the result of the research, it is known that Gynura procumbens (Lour).Merr leaf extract have inhibition zone to Escherichia coli bacteria with the width of the lowest barrier zone of 6 mm at 10% concentration while the width of the highest resistance zone is 20 mm at concentration 50% with 30 mm control. From the statistical test result using Simple Linear Regression, the result of p(0,000) at 95% confdence level (p = 0,000 <α (0,05) meaning that there is inﬂuence of concentration of Gynura procumbens (Lour).Merr leaf extract to zone inhibit of Escherichia coli bacteria diffusion method.Abstrak: Tanaman sambung nyawa atau sering disebut dengan Gynura procumbens (Lour.) Merr merupakan tanaman yang termasuk dalam famili Asteraceae. Berdasarkan hasil skrining ftokimia yang dilakukan, kandungan kimia yang terdapat di dalam daun sambung nyawa adalah fenol, saponin dan steroid. Senyawa fenol dan saponin memiliki mekanisme sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui zona hambat dari ekstrak daun sambung nyawa konsentrasi 10%, 20%, 30%,40% dan 50% terhadap bakteri Escherichia coli pada media muller hinton agar dan untuk mengetahui nilai Resisten, Intermediet dan Sensitif dari ekstrak daun sambung nyawa (Gynura procumbens (Lour).Merr) terhadap zona hambat bakteri Escherichia coli serta menganalisis pengaruh variasi konsentrasi ekstrak daun sambung nyawa (Gynura procumbens (Lour).Merr) terhadap zona hambat bakteri Escherichia coli. Metode penelitian yang digunakan adalah metode ekperimental semu. Berdasarkan hasil penelitian diketahui bahwa ekstrak daun sambung nyawa mempunyai zona hambat terhadap bakteri Escherichia coli dengan luas zona hambatan terendah 6 mm pada konsentrasi 10% sedangkan luas zona hambatan tertinggi 20 mm pada konsentrasi 50% dengan kontrol pembanding sebesar 30 mm. Dari hasil uji statistik menggunakan Regresi Linier Sederhana, didapatkan hasil p (0,000) pada tingkat kepercayaan 95% (p=0,000 < α (0,05) yang berarti ada pengaruh variasi konsentrasi ekstrak daun sambung nyawa terhadap zona hambat bakteri Escherichia coli metode difusi.

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Haque, Ehfazul, Mir Shahriar Kamal, Md Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Chowdhury, Shaila Kabir, Md Shah Amran, and Md Sahab Uddin. "Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens." Current Topics in Medicinal Chemistry 21, no. 29 (December 22, 2021): 2671–86. http://dx.doi.org/10.2174/1568026621666211004094902.

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Gynura procumbens (Lour.) Merr. is a well-known plant used in folkloric medicine in tropical Asian countries. The plant is prevalently employed by traditional healers in the treatment of diabetes, cancer, hypertension, inflammation, fever, and skin disorders. Several scientific studies reported that Gynura procumbens possesses considerable therapeutic value for the development of emerging treatment options. The diverse pharmacological effects of this plant are attributed to its vast phytoconstituent content. Different chemical classes, including alkaloids, flavonoids, phenolics, steroids, proteins, and polysaccharides, have been isolated from this plant. In this review, we tried to explore the different aspects of Gynura procumbens as an established medicinal plant. The data gathered here give an indication that the plant Gynura procumbens is a good natural source of chemical compounds with different types of pharmacological actions, and these chemical compounds can be used as models for the development of de novo therapeutic agents.

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Haque, Ehfazul, Mir Shahriar Kamal, Md Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Chowdhury, Shaila Kabir, Md Shah Amran, and Md Sahab Uddin. "Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens." Current Topics in Medicinal Chemistry 21, no. 29 (December 22, 2021): 2671–86. http://dx.doi.org/10.2174/1568026621666211004094902.

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Gynura procumbens (Lour.) Merr. is a well-known plant used in folkloric medicine in tropical Asian countries. The plant is prevalently employed by traditional healers in the treatment of diabetes, cancer, hypertension, inflammation, fever, and skin disorders. Several scientific studies reported that Gynura procumbens possesses considerable therapeutic value for the development of emerging treatment options. The diverse pharmacological effects of this plant are attributed to its vast phytoconstituent content. Different chemical classes, including alkaloids, flavonoids, phenolics, steroids, proteins, and polysaccharides, have been isolated from this plant. In this review, we tried to explore the different aspects of Gynura procumbens as an established medicinal plant. The data gathered here give an indication that the plant Gynura procumbens is a good natural source of chemical compounds with different types of pharmacological actions, and these chemical compounds can be used as models for the development of de novo therapeutic agents.

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Meiyanto, Edy. "EKSTRAK ETANOLIK DAUN Gynura procumbens (Luor) Merr. MENGHAMBAT PROLIFERASI SEL KANKER PAYUDARA TIKUS PADA KARSINOGENESIS YANG DIINDUKSI DENGAN dimetilbenz(a)antrazena (DMBA)." Pharmacon: Jurnal Farmasi Indonesia 13, no. 1 (January 27, 2015): 12–17. http://dx.doi.org/10.23917/pharmacon.v13i1.21.

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Penelitian sebelumnya menunjukkan bahwa ekstrak etanolik daun Gynura procumbens dapat menghambat pertumbuhan tumor payudara tikus yang diinduksi DMBA. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanolik daun Sambung nyawa (Gynura procumbens (Luor) Merr) pada proliferasi sel kanker payudara tikus yang diinduksi dengan Dimetilbenz(a)antrazena (DMBA). Enam puluh ekor tikus betina galur SD umur 6 minggu dibagi menjadi 6 kelompok yaitu tanpa perlakuan, perlakuan DMBA saja dan empat kelompok perlakuan DMBA+ekstrak. Inisiasi DMBA dilakukan dengan dosis 20 mg/kgBB yang diberikan sebanyak 10 kali dengan frekuensi pemberian 2 kali setiap minggu. Mulai minggu ke-1 (post I) atau ke-6 (post II) kelompok perlakuan mendapat ekstrak etanolik daun Gynura procumbens dalam CMC 0,5 % seminggu 3 kali melalui oral dengan dosis 250 mg/kgBB dan 750 mg/kgBB. Pada minggu ke-16 tikus dikorbankan, jaringan payudara diambil untuk dibuat preparat histologi dengan teknik pewarnaan silver (AgNOR). Mean AgNOR (mAgNOR) dihitung pada setiap preparat tiap kelompok. mAgNOR kelompok perlakuan dibandingkan dengan mAgNOR kelompok tanpa perlakuan. Hasil penelitian menunjukkan ekstrak etanolik daun Gynura procumbens dengan dosis 250 mg/kgBB dan 750 mg/kgBB yang diberikan mulai minggu kesatu maupun ke-6 setelah inisiasi DMBA terakhir dapat mengurangi proliferasi sel kanker payudara tikus. Rata-rata mAgNOR kelompok tanpa perlakuan dan perlakuan DMBA saja masing-masing 0,8 ± 0,34 dan 2,7 ± 0,41, mAgNOR post I kelompok dosis 250 dan dosis 750 masing-masing 1,4 ± 0,39 dan 1,3 ± 0,09, sedangkan mAgNOR post II kelompok dosis 250 dan dosis 750 masing-masing 1,6 ± 0,47 dan 1,5 ± 0,31. Pengamatan terhadap ekspresi COX-2 menunjukkan adanya penurunan pada kelompok perlakuan ekstrak dosis 250 dan 750 mg/kgBB. Hasil-hasil tersebut menunjukkan bahwa ekstrak etanolik daun Gynura procumbens dapat menghambat proliferasi sel-sel tumor payudara yang kemungkinan berhubungan dengan penurunan ekspresi COX-2. Kata kunci: Gynura procumbens, anti-karsinogenesis, proliferasi, AgNOR

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Uthia, Rahimatul, Dina Yuliana, and Widya Kardela. "Antihypertension Activity of Gynura procumbens (L.) Merr. Extract On Blood Pressure And Monoxide Nitrogen Levels In Male White Rats." JPK : Jurnal Proteksi Kesehatan 9, no. 2 (July 6, 2021): 25–31. http://dx.doi.org/10.36929/jpk.v9i2.309.

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Hypertension is closely related to vasodilation disorders because of the decreased availability of nitrogen monoxide (NO). The purpose of this study was to determine the decrease in blood pressure and nitrogen monoxide (NO) levels in rats after administration of Gynura procumbens leaves extract. The results showed that the administration of Gynura procumbens leaves extracts significantly reduced blood pressure and increased NO levels. From the results of Duncan's test, it was found that the dose of 300mg / Kg BW showed a better effect on increasing NO levels (p <0.05). From the results of the study, it can be concluded that the ethanol extract of Gynura procumbens leaves has an antihypertensive activity that can reduce blood pressure and increase the NO level.

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Rosidah, Mun Yam, Amirin Sadikun, and Mohd Asmawi. "Antioxidant Potential of Gynura procumbens." Pharmaceutical Biology 46, no. 9 (January 2008): 616–25. http://dx.doi.org/10.1080/13880200802179642.

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Hamid, Iwan Sahrial, Yuseni Kusuma P., Retno Bijanti, and Bimo Aksono. "The Number of Macrophages and Heterophils on Chick Embryo Chorioallantoic Membrane After Gynura procumbens (Lour) Merr Extract Treatment and bFgF Induction." Indonesian Journal of Cancer Chemoprevention 3, no. 2 (June 30, 2012): 398. http://dx.doi.org/10.14499/indonesianjcanchemoprev3iss2pp398-403.

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Antiangiogenesis (inhibition of new blood vessels formation) has become a strategy to inhibit cancer development. The aim of this experiment was to investigate antiangiogenic effect of Gynura procumbens (Lour) Merr focusing on the decreasing of the number of macrophages and heterophils on chick embryo chorioallantoic membrane. Nine-days-aged-eggs were divided into six groups (eight eggs each group). Group I (positive control) eggs were induced with bFGF+Tris HCl. Group II (negative control) eggs were treated with DMSO+Tris HCl. Group III (treatment I) eggs were induced with 60 ng bFGF and treated with ethanolic extract of G. procumbens leaves with the dose of 60 µg. The following treatment groups, i.e. group IV (treatment II), group V (treatment III), and group VI (treatment IV) were treated with increasing dose of extract, starting from 75 µg, 90 µg, and the last was 110 µg. Eggs were incubated until they reach the age of twelve days to observe macrophages, while to observe heterophils, eggs were incubated until the age of seventeen days. Based on haematoxylin-eosin staining, macrophages in the treatment groups were less than the control positive group (bFGF+Tris HCl), but based on giemsa staining, the effect of Gynura procumbens in decreasing the number of heterophils could not be observed because some blood smears. These analysis suggest that the ethanolic extract of Gynura procumbens leaves can perform as antiangiogenic agent decreasing the number of macrophages.Keywords: antiangiogenic, macrophages, heterophils, Gynura procumbens

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Ishak, Pertiwi, Peter Kabo, and Yulia Yusrini Djabir. "Nefroprotective Effect of Gynura procumbens Extract Against Paracetamol Toxicity in Rats." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 7, no. 2 (October 4, 2021): 181–90. http://dx.doi.org/10.22487/j24428744.2021.v7.i2.15584.

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ABSTRACT Excessive doses of paracetamol have the potential to cause acute kidney injury and even death. Gynura procumbens has been traditionally used as folk-medicine for kidney disease. This study aimed to examine the nephroprotective effect of Gynura procumbens leaf extract against paracetamol-induced nephrotoxicity in rats. Twenty-five male wistar rats (150-200 g) were divided into 5 groups. Healthy control group, placebo group, and 3 extract treatment groups that received either 100 mg/kg, 200 mg/kg or 300 mg/kg dose. The placebo (sodium carboxymethyl cellulose) or extract was given 4 consecutive days prior to paracetamol (2400 mg/kg) administration on day 5. Blood samples were withdrawn before treatment initiated (day 0), after treatment before paracetamol administration (day 5) and 24-hour after paracetamol administration (day 6). Blood samples were analyzed to obtain urea and creatinine levels. In addition, histopathological analysis was performed on the renal tissue. Paracetamol administration was shown to significantly increase the urea and creatinine levels, and the extract at 300 mg/kg dose was able to significantly prevent the elevation of the renal biomarkers. The histopathological analysis also revealed a significant reduction in renal histopathological injury in 300 mg/kg extract group. It can be concluded that the ethanolic extract of the Gynura procumbens at a dose of 300 mg/kg has a good protective effect on kidney function and tissue structure. Key words: Gynura procumbens, nephroprotective, paracetamol

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Ishak, Pertiwi, Peter Kabo, and Yulia Yusrini Djabir. "Nefroprotective Effect of Gynura procumbens Extract Against Paracetamol Toxicity in Rats." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 7, no. 2 (October 4, 2021): 181–90. http://dx.doi.org/10.22487/j24428744.2021.v7.i2.15584.

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ABSTRACT Excessive doses of paracetamol have the potential to cause acute kidney injury and even death. Gynura procumbens has been traditionally used as folk-medicine for kidney disease. This study aimed to examine the nephroprotective effect of Gynura procumbens leaf extract against paracetamol-induced nephrotoxicity in rats. Twenty-five male wistar rats (150-200 g) were divided into 5 groups. Healthy control group, placebo group, and 3 extract treatment groups that received either 100 mg/kg, 200 mg/kg or 300 mg/kg dose. The placebo (sodium carboxymethyl cellulose) or extract was given 4 consecutive days prior to paracetamol (2400 mg/kg) administration on day 5. Blood samples were withdrawn before treatment initiated (day 0), after treatment before paracetamol administration (day 5) and 24-hour after paracetamol administration (day 6). Blood samples were analyzed to obtain urea and creatinine levels. In addition, histopathological analysis was performed on the renal tissue. Paracetamol administration was shown to significantly increase the urea and creatinine levels, and the extract at 300 mg/kg dose was able to significantly prevent the elevation of the renal biomarkers. The histopathological analysis also revealed a significant reduction in renal histopathological injury in 300 mg/kg extract group. It can be concluded that the ethanolic extract of the Gynura procumbens at a dose of 300 mg/kg has a good protective effect on kidney function and tissue structure. Key words: Gynura procumbens, nephroprotective, paracetamol

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Kim, Kyeong Jin, Ah Hyun Gim, Ji Hyun Kim, Do Hee Kim, Seo Rin Lee, Jee Hyun Park, Ji Won Lim, Ji Hoon Ha, and Soo Nam Park. "Antioxidant Activities of Gynura procumbens Extracts." Journal of the Society of Cosmetic Scientists of Korea 41, no. 2 (June 30, 2015): 181–87. http://dx.doi.org/10.15230/scsk.2015.41.2.181.

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Sari, M. P., H. Sinaga, and L. M. Lubis. "The making of Gynura procumbens powder." IOP Conference Series: Earth and Environmental Science 454 (April 15, 2020): 012111. http://dx.doi.org/10.1088/1755-1315/454/1/012111.

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Nurulita, Nunuk Aries, Edy Meiyanto, and Sugiyanto Sugiyanto. "Selectivity of Ethyl Acetate Fraction of Gynura Procumbens on Colon Cancer and Breast Cancer." Indonesian Journal of Cancer Chemoprevention 2, no. 3 (October 31, 2011): 274. http://dx.doi.org/10.14499/indonesianjcanchemoprev2iss3pp274-280.

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Gynura procumbens is widely used as traditional remedy in South-East Asia. Gynura procumbens exhibites anti inflammatory, antioxidant, and reduced blood pressure activity. The aim of this study was to determine chromatographic profile of ethyl acetate fraction of Gynura procumbens (FEG) and to investigate its cytotoxic properties and selectivity to colon cancerand breast cancer cancer cells. The chromatographic profile of FEG was determined using HPTLC densitometric and HPLC. MTT (3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed to determine the growth inhibitory effect of FEG on the growth of WiDr, MCF-7, and T47D cells. NIH3T3, a normal cells was used to determine the selectivity of FEG, which contained small amount of quercetin as identified from chromatographic profile both HPTLC and HPLC. FEG inhibited cell growth of WiDr, of MCF-7 and of T47D cells in time dependent manner. Quercetin affected cell growth inhibition approximately two fold higher at WiDr and MCF-7, whereas FEG had lower effect on T47D cell. Quercetin did not seem as the main active compound of FEG. At this study, FEG caused less inhibition on the growth of NIH3T3 cells than that of on all cell lines. Selectivity index (SI) of FEG on WiDr, MCF-7 and T47D were 4.97, 2.77 and 7.79 respectively. According to the datas obtained, FEG possesses moderate to high cytotoxicity properties on WiDr, MCF-7 and T47D cells. FEG demonstrates selective effect against cancer cells and reveals prospective properties as cancer chemoprevention agent.Keywords: Gynura procumbens, colon cancer, breast cancer, cytotoxicity, selectivity

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Elfrida, Elfrida, Nawir Muhar, Abdullah Munzir, and Amelia Sriwahyuni Lubis. "EFFECTIVENESS OF Gynura procumbens AGAINST Pangasius sp INFECTED WITH Edwardsiella tarda BACTERIA." Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan 20, no. 2 (December 28, 2022): 243. http://dx.doi.org/10.32663/ja.v20i2.3091.

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This study aimed to analyze the effect of soaking the extracts of Gynura procumbens leaves with different concentrations on wound healing of catfish infected with Edwardsiella tarda bacteria. This research was conducted at the Wet Laboratory of the Fish Quarantine and Quality Control Agency of Padang, West Sumatra. This study used an experimental method with a completely randomized design (CRD) consisting of 3 treatments and 4 replications. The treatment of this research was the concentration of the Gynura procumbens leaves consisting of treatment P1 = 2000 ppm; treatment P2 = 3000 ppm and treatment P3 = 4000 ppm. Based on the analysis of variance, the concentration of the leaf extract had a significant effect on wound shrinkage. Duncan's follow-up test (DMRT) showed that the treatment was P1; P2; and P3 there are significant differences in each treatment. it was shown that Gynura procumbens leaf extract with different concentrations had no significant effect (p> 0.05) on the survival of catfish. The lowest survival rate in treatment P1 was 66.67%, and in treatment P2 and P3 was 100%. The best results were found in the P2 treatment of 80.20% on wound shrinkage and 100% on survival rate.

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Sutthammikorn, Nutda, Volaluck Supajatura, Hainan Yue, Miho Takahashi, Sunee Chansakaow, Nobuhiro Nakano, Pu Song, et al. "Topical Gynura procumbens as a Novel Therapeutic Improves Wound Healing in Diabetic Mice." Plants 10, no. 6 (June 1, 2021): 1122. http://dx.doi.org/10.3390/plants10061122.

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Nonhealing wounds are major socioeconomic challenges to healthcare systems worldwide. Therefore, there is a substantially unmet need to develop new drugs for wound healing. Gynura procumbens, a herb found in Southeast Asia, may be an effective therapeutic for nonhealing diabetic wounds. The aim of this study was to evaluate the efficacy of G. procumbens on wound healing in the diabetic milieu. G. procumbens extract was obtained using 95% ethanol and its components were determined by thin layer chromatography. Diabetes was induced in mice using streptozotocin. We found that G. procumbens extract contained stigmasterol, kaempferol and quercetin compounds. Topical application of G. procumbens on the wounded skin of diabetic mice accelerated wound healing and induced the expression of angiogenin, epidermal growth factor, fibroblast growth factor, transforming growth factor and vascular endothelial growth factor. Furthermore, G. procumbens promoted in vitro wound healing and enhanced the migration and/or proliferation of human endothelial cells, fibroblasts, keratinocytes and mast cells cultured in diabetic conditions. Finally, G. procumbens promoted vascular formation in the diabetic mice. To the best of our knowledge, this is the first study that evaluates in vivo wound healing activities of G. procumbens and activation of cells involved in wound healing process in diabetic conditions. The findings that G. procumbens accelerates wound healing and activates cells involved in the wound healing process suggest that G. procumbens might be an effective alternative therapeutic option for nonhealing diabetic wounds.

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Le, Quyen Thi My, Quynh Thi Diem Nguyen, Phu Hoang Dang, Nhi Thi Y. Nguyen, and Quan Le Tran. "Chemical constituents and bioactivity of Gynura procumbens (Lour.) Merr." Science and Technology Development Journal 22, no. 4 (January 24, 2020): 391–99. http://dx.doi.org/10.32508/stdj.v22i4.1725.

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Introduction: Gynura procumbens (Lour.) Merr. (Family: Asteraceae) is mainly popular in South-East Asian countries for its traditional medicinal properties. It is usually used as a traditional medicine for the treatment of eruptive fevers, rash, kidney disease, migraines, constipation, hypertension, diabetes mellitus, and cancer. It is commonly used as a traditional medicine in Vietnam for the treatment of many diseases. Methods: The leaves and trunks of G. procumbens were collected, macerated with methanol. The extracts from MeOH-soluble extract were processed by the column chromatographic technique to give pure compounds and the nuclear magnetic resonance methods were applied to determine their chemical structures. The inhibitory activities of these extracts against α-glucosidase were conducted and compared with acarbose. Results: Seven organic compounds were isolated and determined the structures, including syringic acid (1), quercetin (2), N,N-dimethylanthranilic acid (3), dehydrovomifoliol (4), β-sitosterol 3-O-β-D-glucopyranoside (5), schottenol (6), montanic acid (7). The inhibition of α-glucosidase test results the IC50 values of the four extracts which were lower than those of acarbose. Conclusion: Seven pure compounds were identified from the leaves and trunks of G. procumbens, including two compounds being isolated from G. procumbens for the first time. The test results showed that the the parts of G. procumbens were active as α-glucosidase inhibitor, which would be useful to support the treatment for diabetes.

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Zainal Abidin, Zurina. "OPTIMIZATION OF CHLOROPHYLL EXTRACTION FROM Gynura procumbens." Malaysian Journal of Analytical Science 20, no. 6 (December 8, 2016): 1421–28. http://dx.doi.org/10.17576/mjas-2016-2006-22.

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Jeon, Hyeong-Ju, and Hye-Jin Kwon. "Anti-inflammation Effect of Gynura Procumbens extract." Journal of Digital Convergence 14, no. 10 (October 28, 2016): 515–20. http://dx.doi.org/10.14400/jdc.2016.14.10.515.

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Ahmed, H., and S. Shehu. "Ethno-botanical and Pharmaceutical Properties of Mollucan Spinach (Gynura procumbens Lour. Merr)." Journal of Applied Sciences and Environmental Management 26, no. 12 (December 31, 2022): 1925–35. http://dx.doi.org/10.4314/jasem.v26i12.6.

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Recently there has been increase in patronage of herbal medicine due to economic constrain particularly among low income earners in the developing countries such as Nigeria. Gynura procumbens, (Molucan spinach) is widely used in traditional medicine for treatment of wide ailments such as fever, malaria, anti-glycaemic, rheumatism, hypertension, diabetes mellitus, cancer, kidney diseases, anti-inflammatory, constipation, male sterility and body pain among others. This study reviews the ethnobotanical and pharmaceutical properties of G. procumbens (Lour.) Merr hence provided some data and information on the biological activity of G. procumbens which evaluated and validated its efficacy and safety in the treatment of different ailments. Based on the traditional uses of G. procumbens, the specie appears to possess high therapeutic potential for treatment of various diseases hence making it a target for pharmacological studies. Despite the knowledge and use of ethnomedicine the current scientific evidence on biological activities of G. procumbens remain scanty.

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Mohamad Bukhori, Mohamad Fhaizal, Hawa ZE Jaafar, Ali Ghasemzadeh, Uma Rani Sinniah, and Gayatri Karipaya. "Preliminary Study on the Effect of Nitrogen and Potassium Fertilization on Phytochemical Content Quality of Gynura procumbens." Malaysian Journal of Fundamental and Applied Sciences 17, no. 4 (August 31, 2021): 365–88. http://dx.doi.org/10.11113/mjfas.v17n4.2053.

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Gynura procumbens is an herbaceous plant. Despite the progressive reports on the pharmacological properties, many are overlooking at the importance of agronomic requirements, such as fertilization, to produce high phytochemical content which have not been conclusively concluded.

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Iskander, M. N., Y. Song, I. M. Coupar, and W. Jiratchariyakul. "Antiinflammatory screening of the medicinal plant Gynura procumbens." Plant Foods for Human Nutrition 57, no. 3/4 (2002): 233–44. http://dx.doi.org/10.1023/a:1021851230890.

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Hu, Ju-Wu, Jing Wu, Yu Zhang, Bin-Hua Huang, Jian-Ping Fu, Lei Wu, and Gang Xu. "Chemical Constituents of the Stems of Gynura procumbens." Chemistry of Natural Compounds 55, no. 3 (May 2019): 583–85. http://dx.doi.org/10.1007/s10600-019-02751-2.

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Pramukantoro, Ganet Eko, and Sri Rejeki Handayani. "Uji Efektifitas Gel Ekstrak Sambung Nyawa (Gynura Procumbens (Lour.)Merr.) Terhadap Penyembuhan Luka Pada Kelinci Hiperglikemia." Jurnal Farmasi Indonesia 18, no. 2 (November 20, 2021): 152–58. http://dx.doi.org/10.31001/jfi.v18i2.778.

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Kondisi hiperglikemia bisa menghambat proses penyembuhan luka. Pemberian gel ekstrak daun sambung nyawa (Gynura procumbens (Lour.)Merr.) menjadi salah satu pilihannya. Tujuan jangka panjang penelitian ini adalah membuktikan gel ekstrak daun sambung nyawa (Gynura procumbens (Lour.)Merr.) mampu menyembuhkan luka pada hewan uji yang diinduksi aloksan. Target khusus yang ingin dicapai adalah memperoleh obat alam berkhasiat mencegah terjadinya luka diabetik dan mengetahui dosis efektif gel ekstrak daun sambung nyawa (Gynura procumbens (Lour.)Merr.) sebagai penyembuh luka pada kondisi hiperglikemia. Penelitian ini menggunakan kelinci putih sebanyak 5 ekor. Pengujian dilakukan dengan membuat luka pada punggung hewan uji DM yang diinduksi aloksan. Aktivitas penyembuhan luka dilihat dengan membagi punggung hewan uji menjadi 5 bagian yang diberi perlakuan sesuai kelompoknya. Kelompok perlakuan dan kelompok kontrol positif dioles dengan gel 2 x sehari selama 9 hari dan dilakukan pengukuran panjang luka pada hari ke 1, 3, 5, 7, dan 9. Aktivitas penyembuh luka diabetik ditunjukkan dengan cara menghitung panjang luka masing-masing perlakuan dan dianalisa dengan uji Anova satu jalan dengan taraf kepercayaan 95%. Hasil dari penelitian menunjukkan bahwa formulasi gel ekstrak daun sambung nyawa dengan basis CMC Na memiliki hasil uji kualitas fisik yang baik seperti uji organoleptis warna sesuai warna ekstrak, aroma khas ekstrak daun sambung nyawa, penampilan kental, homogen, memiliki pH 6. Untuk uji daya sebar, daya lekat, dan viskositas, masing-masing memenuhi persyaratan yang diinginkan. Uji aktivitas penyembuhan luka menunjukkan bahwa kelompok gel ekstrak daun sambung nyawa dengan konsentrasi 5% mampu menyembuhkan paling baik, dengan persentase penyembuhan luka sebesar 67,00%.

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Bae, Dan-Bi, Kyoung-Hee Kim, and Hong-Sun Yook. "Antioxidant and Tyrosinase Inhibitory Activities of Fermented Gynura procumbens." Journal of the Korean Society of Food Science and Nutrition 48, no. 11 (November 30, 2019): 1214–22. http://dx.doi.org/10.3746/jkfn.2019.48.11.1214.

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Choi, Sung-In, Mi Hwa Park, and Ji-Sook Han. "Gynura procumbens Extract Alleviates Postprandial Hyperglycemia in Diabetic Mice." Preventive Nutrition and Food Science 21, no. 3 (September 30, 2016): 181–86. http://dx.doi.org/10.3746/pnf.2016.21.3.181.

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Uthia, Rahimatul, Elin Resti Ananda, and Ifora Ifora. "Gynura procumbens (Lour.) Merr. Leaves Against Mice’s Antibody Titer." JURNAL PROTEKSI KESEHATAN 8, no. 2 (December 13, 2019): 13–19. http://dx.doi.org/10.36929/jpk.v8i2.154.

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The body's defense system can be enhanced by certain compounds that are immunostimulant. An antibody titer is a measure of the body's level of immunity to a disease. Titers are usually expressed in terms of the number of times they can thin the blood until they cannot find any more antibodies. This study aims to determine the activity of the extracts of the leaves of Gynura Procumbens (Lour.) Merr. against antibody titers, the number, and percentage of leukocyte cells of white male mice. 25 mice were divided into 5 groups consisting of negative control, positive control, group dose 75 mg/kg body weight, 150 mg/kg body weight, 300 mg/kg body weight. The extract is given for 7 days orally. The results showed that the administration of leaf extracts can increase antibody titers and increase with increasing doses, as well as increasing the total number of leukocytes and the percentage of leukocyte cells significantly (P <0.05).

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Rosidah, Mun Fei Yam, Amirin Sadikun, Mariam Ahmad, Gabriel Akyirem Akowuah, and Mohd Zaini Asmawi. "Toxicology evaluation of standardized methanol extract of Gynura procumbens." Journal of Ethnopharmacology 123, no. 2 (June 2009): 244–49. http://dx.doi.org/10.1016/j.jep.2009.03.011.

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Hu, Ju-Wu, Jing Wu, Xiong-Hui Li, Bin-Hua Huang, En Yuan, Lei Wu, and Guang-Qiang Ma. "A New Cerebroside from the Roots of Gynura procumbens." Chemistry of Natural Compounds 55, no. 6 (November 2019): 1053–55. http://dx.doi.org/10.1007/s10600-019-02891-5.

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Zhang, Ying, Kun Jiang, Yi-Ming Zhai, Jun-Jie Tan, Da-Li Meng, Sha-Li Guo, Shi-Jin Qu, and Chang-Heng Tan. "ChemInform Abstract: Sesquiterpenoids and Their Glycosides from Gynura procumbens." ChemInform 45, no. 35 (August 14, 2014): no. http://dx.doi.org/10.1002/chin.201435205.

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Ambarwati, Neneng Siti Silfi, Rita Susesty, and Devi Sulastiowati. "The Eﬀect of Sambung Nyawa (Gynura procumbens) Leaves Extract to Reduction of Dandruﬀ on The Scalp." JURNAL ILMU KEFARMASIAN INDONESIA 19, no. 1 (April 21, 2021): 49. http://dx.doi.org/10.35814/jifi.v19i1.942.

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Gynura procumbens is a medicinal plant commonly used in Asian countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. G. procumbens content ﬂavonoids and glycosides and have bacteria activity and anti-fungal activity such as Candida albicans and Aspergillus niger. The purpose of this study was to obtain empirical data about the eﬀect of using the G. procumbens leaves extract on reducing dandruﬀ on the scalp. The extract was obtained by the maceration method using 70% ethanol solvent. The phytochemical compound content is determined with spectrophotometry ultraviolet. Two observers observe the scalp by using observation sheets and grating instruments assisted by a skin and hair analyzer. The reduction of scalp dandruﬀ was the diﬀerence between the initial the results and the ﬁnal test (after treatment). The sample was selected using a purposive sampling technique totaling ten people and divided into two groups (experimental and control groups). The results showed that the calculation of hypothesis testing after analyzing the data obtained a value of t count (5.817)>t table (1.86). This showed an eﬀect of using the G. procumbens leaves extract as a shampoo for reducing dandruﬀ on the scalp. The use of G. procumbens leaves extract as shampoo can reduce dandruﬀ.

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Rismayani, SP, NFN Rismayani. "SIKLUS HIDUP LARVA Nyctemera coleta DAN Paliga auratalis SEBAGAI HAMA PADA TANAMAN DAUN SAMBUNG NYAWA (Gynura procumbens)TANAMAN DAUN SAMBUNG NYAWA (Gynura procumbens) Life Cycle of Nyctemera coleta and Paliga auratalis In Gynura procumbens Leaf." Buletin Penelitian Tanaman Rempah dan Obat 28, no. 1 (June 9, 2017): 89. http://dx.doi.org/10.21082/bullittro.v28n1.2017.89-96.

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Sambung nyawa (Gynura procumbens) merupakan salah satu tanaman obat yang mempunyai beragam manfaat bagi kesehatan, bermanfaat sebagai analgesik hingga antimikroba. Pada tanaman ini terdapat dua spesies larva dari ordo Lepidoptera yang merupakan hama perusak daun, sehingga menghambat pertumbuhan sambung nyawa. Tujuan penelitian untuk mengetahui perilaku dan siklus hidup dari kedua jenis ulat yang ditemukan di pertanaman sambung nyawa, sebagai dasar dalam penelitian pengendalian hama pada pertanaman sambung nyawa. Penelitian dilakukan di Laboratorium Hama Balai Penelitian Tanaman Rempah dan Obat (Balittro) sejak Januari sampai April 2016. Larva yang dikumpulkan dari lapangan dipelihara dan dikembangbiakkan di laboratorium. Parameter yang diamati meliputi stadium dan karakteristik tiap stadium dari siklus hidup dua spesies hama yang ditemukan di pertanaman sambung nyawa. Hasil penelitian menunjukkan bahwa dua jenis larva yang ditemukan di pertanaman sambung nyawa adalah Nyctemera coleta dan Paliga auratalis, termasuk dalam ordo Lepidoptera. Stadium larva N. coleta merupakan stadium yang paling panjang dengan kisaran umur larva rata-rata 24 hari. Larva N. coleta merusak daun dengan memakan jaringan daun sehingga meninggalkan tulang-tulang daun. Stadium yang paling panjang pada P. auratalis adalah stadium pupa dengan rata-rata kisaran umur stadium 13,1 hari. Larva P. auratalis merusak daun sambung nyawa dengan memakan daun dan juga merekatkan sisi-sisi daun menggunakan saliva yang dikeluarkan dari mulutnya.

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Nasiruddin, M., and Shankar Narayan Sinha. "Phytochemical screening and antioxidant, antibacterial efficacy of Gynura procumbens (Lour.) Merr." Asian Journal of Medical and Biological Research 6, no. 2 (July 7, 2020): 187–95. http://dx.doi.org/10.3329/ajmbr.v6i2.48049.

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The emergent medicinal plant Gynura procumbens to the greatest extent familiar in Bangladesh, India, Thailand and Southeast Asia. The plant usually used as a traditional medicine for the treatment of various diseases along with diabetes mellitus. The present investigation was try to display screen qualitative and quantitative phytochemical compositions of ethanol extract of Gynura procumbens leaves as an instance soluble sugar, total amino acids, protein, chlorophyll, flavonoids, tannins, phenol as standard techniques and antioxidant activity as DPPH radical scavenging assay and compare the antibacterial activity by using agar well diffusion method. Qualitative evaluation exhibit present of most of the phytochemicals and quantitative evaluation revealed primary chemical constituents consisting of amino acids (16.34 mg/g), soluble sugar (1.81 mg/g), total chlorophyll (0.52 mg/g), chlorophyll-a (0.34 mg/g), chlorophyll-b (0.145 mg/g) and lowest amount of phytochemical turned into protein (0.12 mg/g). Secondary chemical constituents together with flavonoids (30.32 mg/g), phenols (10.17 mg/g) and tannin (0.96 mg/g). The observation also confirmed great antioxidant activity in a concentration dependent manner via the scavenging of 1, 1-diphenyl-1-picrylhydrazyl radical (DPPH). Result confirmed that, the studied sample has high antioxidant efficacy. The antibacterial interest confirmed as negative effects in all bacteria’s tested. These results advise that Gynura extract is a good herbal supply of bioactive compounds. Asian J. Med. Biol. Res. June 2020, 6(2): 187-195

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Prasetya, Angga, Sri Nuryani Hidayah Utami, and Eko Hanudin. "Effects of Shade and Biochar Application on the Quercetin Content of Longevity Spinach in Inceptisol." Applied and Environmental Soil Science 2021 (April 14, 2021): 1–12. http://dx.doi.org/10.1155/2021/6699873.

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Traditional medicines have been used in both developed and developing countries for a long time, one of which is longevity spinach (Gynura procumbens). Its plants are one type of plant that is used by the community to treat various diseases with their flavonoid content. This plant produces various flavonoids, such as quercetin, which can be optimized by providing shade and increasing nitrogen nutrients by giving biochar and fertilizing. This study aimed to determine the effects of biochar, shade, and fertilizer on the growth and quercetin content of Gynura procumbens plants. This research was arranged in a randomized complete block design (RCBD) with two factors. The first factor was the administration of biochar at four doses, consisting of B0 (without biochar), B10 (biochar 10 tons/ha), B15 (biochar 15 tons/ha), and B20 (biochar 20 tons/ha). Meanwhile, the second factor was the intensity of the shade with three levels of treatment, namely, I0 (without shade), I50 (50%), and I70 (70%). The results showed that the addition of 15 ton/ha of biochar with 70% shade increased the quercetin content by 0.51%.

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Uthia, Rahimatul, Devina Prima Yolanda, Aried Eriadi, and Dwi Dinni Aulia Bakhtra. "Laxative Activity Test of Gynura procumbens (Lour.) Merr. Leave on White Male Mice Induced by Loperamide." Metamorfosa: Journal of Biological Sciences 6, no. 2 (September 21, 2019): 137. http://dx.doi.org/10.24843/metamorfosa.2019.v06.i02.p01.

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Constipation is a symptom of a problematic, non-smooth and irregular defecation process. While laxative is a substance that stimulates intestinal peristalsis as a reflex of direct stimulation of the intestinal wall that can cause or facilitate defecation. This study aimed to determine the ethanol extract of the leaves of Gynura procumbens (L.) Merr. effect as a laxative in white male mice induced by loperamide. The methods used for laxative testing are defecation patterns and intestinal transit methods. The parameters observed included frequency of defecation, stool consistency, stool weight every 30 minutes for 4 hours, and the length of the activated carbon in the mice's intestine. The extract was administered orally at a dose of 75 mg/kg BW, 150 mg/kg BW and 300 mg/kg BW, as a comparison used negative control (Na CMC). From the results of the study, it was found that the administration of ethanol extracts of Gynura procumbens (Lour.) Merr. leaves at the dose of 150 mg/kg BW gave laxative activity to white male mice (P <0.05).

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Sa'adah, Ira Nailas, Yosephine Sri Wulan Manuhara, and Alfinda Novi Kristanti. "Evaluation of Flavonoid Content from Shoot Culture of Gynura procumbens in Balloon-type Bubble Bioreactors." Majalah Obat Tradisional 27, no. 2 (August 31, 2022): 120. http://dx.doi.org/10.22146/mot.72734.

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Gynura procumbens has been widely used to treat several health disorders, such as hyperglycemia, hypertension, diabetes, and allergies. This study aimed to determine the flavonoid content of G. procumbens cultured in a balloon-type bubble bioreactor using various sucrose concentrations (10, 30, and 50 g/L) and explant densities (5, 10, and 15 explants). The plant parts used were stem nodes of G. procumbens, grown in a balloon-type bubble bioreactor using Murashige and Skoog (MS) liquid media with IAA 2 mg/L and BAP 4 mg/L. The total flavonoid content was measured using a UV-Vis spectrophotometer (λ= 510 nm), and the flavonoid profile was tested using thin-layer chromatography (TLC). The administration of 10 g/L sucrose produced the highest total flavonoid production. In the treatment of explant density, the most increasing total flavonoid production was obtained in the treatment of 5 explants. The TLC results showed that each treatment forms spots like standard. This study proved that sucrose and explant densities culture on balloon-type bubble bioreactor method had optimized the production of flavonoids of plant shoots of G. procumbens culture.

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Akon, MOS, DK Datta, T. Biswas, K. Nakamura, and MK Rahman. "Influence of organic manures on the growth of diabetes preventive medicinal plant Gynura, Gynura procumbens." Journal of Biodiversity Conservation and Bioresource Management 4, no. 2 (December 17, 2018): 61–66. http://dx.doi.org/10.3329/jbcbm.v4i2.39850.

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A pot experiment was carried out to evaluate the effects of various organic manures on the growth performance and biomass production of Gynura procumbens in the net house of the Department of Soil, Water and Environment, University of Dhaka. Seven types of manures, viz. ACI, BGF-1, Mazim, Vermicompost, Sufola, GTS and Poultry litter composts were used separately at the rate of 15 ton/ha. Highest height (78cm) in poultry litter compost, leaf number (208.33 no./plant) in sufola manure, leaf area (53.64 cm2/plant) in vermicompost, and branch (3.67 no./plant), girth (3.07cm/plant), fresh weight (202.28g/plant) and dry weight (22.44g/plant) were recorded in poultry litter compost treatment at harvest. Height, leaf area, and fresh and dry weights of leaf varied significantly (p≤ 0.5) and increased with time. Results showed that the overall best growth performance was achieved in poultry litter compost. J. Biodivers. Conserv. Bioresour. Manag. 2018, 4(2): 61-66

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Savitri, Evika Sandi, and Farrikhatun Khusnia. "Growth and Flavonoid Content of Gynura procumbens (Lour) Merr. in Different Soil Water Content." Jurnal Biodjati 4, no. 2 (November 29, 2019): 298–304. http://dx.doi.org/10.15575/biodjati.v4i2.4446.

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Gynura procumbens contains tannins, saponins, steroids, triterpenoids, essential oils and flavonoids which have bioactivity as a medicine for various diseases. One effort to obtain the quality of medicinal plants uses management of soil water content. The opti-mum of soil water content will support optimal growth of a plant. Whereas in conditions of low soil water content resulted in the induc-tion of the production of secondary metabolites as a self-defense sys-tem. This study aimed to determine the effect of soil moisture content on the growth and total content of plant flavonoids G. procumbens. This study was carried out experimentally using a one-factor com-plete randomized design (CRD) consisting of 4 treatments with five replications. The treatment used is the difference in soil water content of 40%, 60%, 80% and 100% field capacity. The data obtained in the form of quantitative data will be analyzed by One Way ANOVA Test. Measurement of the content of total flavonoid compounds was car-ried out using UV-Vis spectrophotometer analysis. The results of the study indicate the influence of soil moisture level on the growth and total content of G. procumbens. Parameter growth of fresh weight, dry weight, and root G. procumbens showed an increase in 40% soil water content. The flavonoid content showed the highest total flavo-noid content 18.884 mg/g in the 40% field capacity soil water content

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Kamaruzaman, Khaidatul Akmar, Wan Mohd Aizat, and Mahanem Mat Noor. "Mass spectrometry data of diabetic rat sperm proteome treated with Gynura procumbens aqueous extract." F1000Research 8 (June 11, 2019): 844. http://dx.doi.org/10.12688/f1000research.19222.1.

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Diabetes mellitus has a deleterious effect on the male reproductive system, especially on sperm quality and spermatogenesis. Gynura procumbens (G. procumbens) is a traditional herb known for its ability to improve the fertility of diabetes-induced male rats. This study was designed to identify the differential expression of sperm proteins after treatment with G. procumbens aqueous extract on diabetes-induced male rats. The sperm proteome was profiled using label-free shotgun proteomics analysis. Sprague Dawley rats used in this study were divided randomly into four groups. One group was a normal control group (healthy rats), while the three other groups were induced with 50 mg/kg bodyweight (BW) of streptozotocin (STZ) to emulate the diabetic condition. The diabetic rats were divided into negative control (non-treated diabetic), metformin-treated (positive control) and G. procumbens aqueous extract-treated (450 mg/kg BW) groups. Oral treatments were administered for 14 consecutive days before the rats were euthanized. Total sperm protein samples were extracted from the caudal epididymis and run through SDS-PAGE. Later, samples were digested using trypsin before liquid chromatography-tandem mass spectrometry (Thermo Orbitrap Fusion) analysis. The acquired data were processed using MaxQuant and Perseus software. The mass spectrometry proteomics data is available through ProteomeXchange Consortium via the PRIDE partner repository, with the dataset identifier PXD011373.

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Cao, Ming-Yuan, Jing Wu, Lei Wu, Zhen Gu, Ju-Wu Hu, Chuan-Qi Xie, and Wei Xiong. "Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via Regulation of the PI3K/Akt and MAPK Signaling Pathways." Evidence-Based Complementary and Alternative Medicine 2022 (April 16, 2022): 1–10. http://dx.doi.org/10.1155/2022/5925626.

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Gynura procumbens is a traditional herb and food extensively cultivated in China and Southeast Asian countries. In this work, the crude extract (CE) of G. procumbens was purified with macroporous resin to obtain the refined fraction, and its anti-inflammatory activity was compared with that of CE. Moreover, the detailed mechanisms of anti-inflammatory activity were also investigated for the first time. The results indicated that CE was more effective in anti-inflammatory activity and it could reduce the secretion of NO, TNF-α, and PGE2 via decreasing the iNOS, TNF-α, and COX-2 genes transcription and related proteins translation, which were associated with the inhibition of AP-1 and NF-κB nuclear translocation and downregulation of PI3K/Akt and MAPK signaling pathways. In conclusion, the extract of G. procumbens has a promising potential in inflammation-related disorders alleviation, and these findings could provide the basis for the comprehensive utilization of G. procumbens and the new functional food development.

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Septaningsih, Dewi Anggraini, Cecep Abdurohman Putra, Irma Herawati Suparto, Suminar Setiati Achmadi, Rudi Heryanto, and Mohamad Rafi. "Phytochemical Profiling of Gynura procumbens (Lour.) Merr. Leaves and Stem Extracts Using UHPLC-Q-Orbitrap HRMS." Indonesian Journal of Chemistry 22, no. 6 (October 23, 2022): 1553. http://dx.doi.org/10.22146/ijc.74236.

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In Indonesia, Gynura procumbens (Lour.) Merr., known as Longevity Spinach or Sambung Nyawa, is commonly grown in tropical and subtropical Asian countries. Many biological activities of G. procumbens have been reported. As we know, the composition and concentration of metabolites, as well as plant parts will significantly affect the biological activities. In this work, UHPLC-Q-Orbitrap-HRMS was used for the putative identification of metabolites present in 70% ethanol extract of G. procumbens leaves and stem extract. Also, we performed clustering of G. procumbens leaves and stem extracts using principal component analysis (PCA) with the peak area of the identified metabolites as the variable. Thirty-one metabolites were identified, and the number of identified peaks in the leaves is higher than in the stem. Those identified metabolites are phenolics, fatty acids, oxo monocarboxylic acids, porphyrins, and chlorophyll fragments. The PCA results showed that the leaves and stem extracts could be grouped, indicating that the composition and concentration of detected compounds differed.

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Tahsin, Md Rafat, Tanzia Islam Tithi, Sabiha Rahman Mim, Ehfazul Haque, Arifa Sultana, Nasiba Binte Bahar, Raju Ahmed, et al. "In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves." Evidence-Based Complementary and Alternative Medicine 2022 (January 19, 2022): 1–18. http://dx.doi.org/10.1155/2022/9095504.

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Background. Diabetes mellitus is one of the most notable health dilemmas. Analyzing plants for new antidiabetic remedies has become an impressive territory for life science researchers. Gynura procumbens has long been used to treat diabetes. Thus, we strived to ascertain the hypoglycemic potentiality of extract of leaves of G. procumbens by in vivo and in silico approaches. Methods. Fresh leaves of G. procumbens were collected and shade-dried to prepare ethanolic extracts to evaluate pharmacological parameters. Diabetes was induced in rats via injecting alloxan through the intraperitoneal route at a dose of 150 mg/kg body weight. Humalyzer 3000 was used to perform a biochemical assay of collected samples from rats. Anti-hyperglycemic activity study along with overdose toxicity test was performed. The pharmacological activity of this plant was also evaluated through a molecular docking study. This in silico study investigated the binding affinity of natural ligands from G. procumbens against glycoside hydrolase enzymes. Results. We detected a peak plasma concentration of G. procumbens at 3 hours 45 minutes that is roughly similar to the peak plasma concentration of metformin. Again, in OGTT and anti-hyperglycemic tests, it has been ascertained that both plant extract and metformin can exert significant P < 0.05 and highly significant P < 0.01 hypoglycemic activity in a dose-dependent manner. Metformin exhibited better therapeutic efficacy than that of plant extract, but it possessed null statistical significance. Also, our safety profile expressed that, similar to metformin, the plant extract can restore the disturbed pathological state in a dose-oriented approach with a wide safety margin. In silico study also validated the potentialities of natural constituents of G. procumbens. Conclusion. This study suggested that G. procumbens can be considered as potential antidiabetic plant. Robust and meticulous investigation regarding plant chemistry and pharmacology in the future may bring about a new dimension that will aid in discovering antidiabetic drugs from this plant in the diabetes management system.

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Setyowati, E., Z. Ikawati, T. Hertiani, and I. D. P. Pramantara. "HMG-CoA reductase and lipase enzyme inhibition from combination of Gynura procumbens and Curcuma xanthorrhiza aqueous extract." Food Research 5, no. 2 (April 25, 2021): 386–92. http://dx.doi.org/10.26656/fr.2017.5(2).493.

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Lifestyle habits related to consuming excessive fatty foods lead to high levels of lipids in the blood. Some drugs are used to reduce lipids by inhibiting the action of the enzyme HMG-CoA reductase and the pancreatic lipase. The Curcuma xanthorrhiza rhizome and Gynura procumbens leaves were empirically used to reduce cholesterol and lipid levels. This study used the combination of aqueous extract of G. procumbens and C. xanthorrhiza rhizomes (4:1) and their single forms as herbs tested. Furthermore, this study aimed to determine the activity of the tested herbs in inhibiting the enzymatic actions of HMG-CoA reductase and pancreatic lipase in vitro, compared with quercetin, curcumin, and positive control. The results showed that the aqueous extract of C. xanthorrhiza with an IC50 value of 127.54 ppm has the highest activity in inhibiting the enzyme HMG-CoA reductase compared to the aqueous extract of G. procumbens and their combination. In the inhibition of lipase enzyme, G. procumbens aqueous extract had the most potent inhibitory activity compared to C. xanthorrhiza and their combination with an IC50 value of 100.08 ppm.

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Mustofa. "Potential Of Sambung Nyawa Leaves (Gynura Procumbens) As An Antidiabetic Medicine." Eureka Herba Indonesia 1, no. 2 (November 23, 2020): 32–35. http://dx.doi.org/10.37275/ehi.v1i2.8.

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Diabetes mellitus is a metabolic disease characterized by an increase in blood sugardue to defects in insulin secretion, insulin sensitivity, or both. The number ofpeople with diabetes mellitus in Indonesia has increased every year. The numberof people with diabetes is 6.9% in 2013 to 10.9% in 2018. Various therapies have beencarried out for the treatment of Diabetes Mellitus, one of which is herbal therapy.Gynura Procumbens is a plant that is widely used as a treatment for diabetes mellitus,kidney, rash and fever, and hypertension. The flavonoid content in GynuraProcumben replaces the decrease in blood sugar. This review article attempts toexplain the role of Gynura Procumbens as an antidiabetic therapy in previous studies.The method used in this article is through searching articles through the NCBIdatabase and Google Scholar. The results of an article search found that GynuraProcumben has antidiabetic potential which can reduce blood sugar in patients withDiabetes Mellitus

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Faizah, Hanik, Ikhlasotul Fawaidah, Najmatul Millah, Ninik Fadhillah, and Muh Ma’arif. "EFFECT OF VARIOUS SUBSTRATES IN NON-CIRCULATING HYDROPONIC SYSTEMS AND SOIL MEDIA ON THE GROWTH OF Gynura procumbens." JURNAL BIOSAINS 6, no. 3 (December 10, 2020): 103. http://dx.doi.org/10.24114/jbio.v6i3.20101.

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The limitations of conventional soil cultivation in producing medicinal plants emerge an interest in searching various alternative cultivation systems, one of which is the hydroponic system. This study aimed to investigate the effect of various substrates in non-circulating hydroponic systems and soil media on the growth of Gynura procumbens. Non-circulating hydroponic cultivation of Gynura procumbens was carried out using stem cuttings. The stem cuttings were transferred to each net pot containing substrates such as rockwool, tree ferns fiber, and sawdust. The net pots were then placed in a tray comprising AB mix 6 ml/L of water. The lower 2-cm-portion of the net pots was immersed in a nutrient solution. Whereas in the conventional soil cultivation, the stem cuttings were transferred to the polybags containing soil media: compost (1: 1). After 28 days of cultivation, the plant growths were measured. The results showed that the use of various substrates in non-circulating hydroponics increased plant growth compared to conventional soil cultivation. Rockwool treatment obtained the highest number of leaves (14,833 ± 5,269 strands), number of roots (20,333 ± 6,121 stands), fresh weight (1.34 ± 0.511 g) and dry weight (0.088 ± 0.031 g).

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Da'i, Muhammad, Astrina Dewi Ratnaningrum, Arifah Sri Wahyuni, Rosita Melannisa, and Ika Trisharyanti Dian Kusuma. "UJI AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. DENGAN METODE DPPH (1,1- Difenil-2- Pikril Hidrazil) SERTA PENETAPAN KADAR FENOLIK TOT." Pharmacon: Jurnal Farmasi Indonesia 13, no. 2 (December 1, 2012): 41–46. http://dx.doi.org/10.23917/pharmacon.v13i2.8.

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Daun Elephantopus schaber L. (tapak liman), Ocimum basilicum L.forma citratum Back., (selasih) Graptophylum pictum Griff (daun ungu), dan Gynura procumbens Merr. (sambung nyawa) memiliki kandungan kimia yang dapat berperan sebagai antiradikal, diantaranya adalah senyawa fenolik. Penelitian ini dilakukan untuk melihat korelasi kandungan fenolik total keempat daun terhadap aktivitas antiradikalnya. Sampel uji yaitu ekstrak etanol daun selasih, ungu, sambung nyawa, dan tapak liman ditentukan aktivitas antiradikal dengan menggunakan metode DPPH (1,1 difenil-2-pikrilhidrazil) kemudian dihitung nilai inhibitory concentration (IC50). Kandungan fenolik total ditentukan secara spektrofotometri menggunakan pereaksi Folin-Ciocalteu dan dihitung sebagai GAE (gallic acid equivalent) yaitu jumlah kesetaraan miligram asam galat dalam satu gram sampel. Penelitian menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman memiliki aktivitas antiradikal dengan nilai IC50 berturut-turut 36,028; 54,998; 103,650; 252,857µg/mL dan kadar fenolik total berturut-turut 167,451; 147,064; 39,371 dan 20,539 mg/g sampel. Hasil penelitian secara keseluruhan menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman berkorelasi positif terhadap aktivitas antiradikalnya. Kata kunci: Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr.

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Idris, Sitinoor Adeib, and Masturah Markom. "Effect of Water Content in Co Solvent on Yield of Supercritical Fluid Extraction of Gynura procumbens Leaves." Journal of Computational and Theoretical Nanoscience 17, no. 2 (February 1, 2020): 1203–6. http://dx.doi.org/10.1166/jctn.2020.8790.

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Gynura procumbens also recognized as Sambung Nyawa is a type of the herbs found in Malaysia, Indonesia and Thailand. It has been consumed as ‘ulam’ by whom that aware of its potential as medicinal remedy and some even drink it as tea for theuraphatic effect. Supercritical fluid extraction is a fast technique to extract valuable compounds from plant parts especially from leaves and seeds. A preliminary study on the effect of solvent water ratio towards yield of Gynura procumbens is conducted at pressure of 20 MPa, temperature of 70 °C, static time of 15 minutes, ethanol as the co solvent and flow rate of 4 ml/min. The time of extraction is 60 minutes. The solvent water ratio was set as follows: 100% ethanol, 75% ethanol and 50% ethanol. The yield obtained are 1.8267%, 0.5933% and 0.9733% for 100%, 75% and 50% ethanol respectively. The extract is then further analysed using high pressure liquid chromatography to determine valuable compounds extracted within the stipulated time at different solvent water ratio. Reversed phase high performance liquid chromatography separation was done using 0.1% phosphoric acid: acetonitirile as eluent in mobile phase to determine flavonoid compounds.

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46

Manogaran, Manimegalai, Vuanghao Lim, and Rafeezul Mohamed. "Response to "Ipolamiide and other phytoconstituents of the Gynura procumbens"." Journal of Herbmed Pharmacology 9, no. 2 (March 22, 2020): 172–73. http://dx.doi.org/10.34172/jhp.2020.23.

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Anuar, Emynurshiela, Umarqayum Abu Bakar, and Mahanem Mat Noor. "Kesan Gynura procumbens terhadap Integriti DNA dan Kualiti Sperma Mencit." Sains Malaysiana 47, no. 9 (September 30, 2018): 1991–97. http://dx.doi.org/10.17576/jsm-2018-4709-06.

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Pestrenin, L. D., B. V. Kurtsev, I. L. Gulyaeva, I. A. Bulatova, and A. M. Miftakhova. "GYNURA PROCUMBENS: REVIEW OF BIOLOGICAL ACTIVITIES AND THEIR POSSIBLE MECHANISMS." Современные проблемы науки и образования (Modern Problems of Science and Education), no. 3 2020 (2020): 105. http://dx.doi.org/10.17513/spno.29863.

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Banu, Tanjina Akhtar, Barna Goswami, Shahina Akter, Mousona Islam, Tammana Tanjin, Ahashan Habib, and Salim Khan. "High Frequency In vitro Regeneration of Gynura procumbens (Lour.) Merr." Plant Tissue Culture and Biotechnology 27, no. 2 (December 27, 2017): 207–16. http://dx.doi.org/10.3329/ptcb.v27i2.35026.

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An efficient rapid in vitro regeneration protocol was described from nodal segment, leaf and petiole explants. MS medium supplemented with 1.0 mg/l BAP and 0.5 mg/l IAA was found best for the multiple shoot formation from nodal segments. In this combination 99% explants produced multiple shoots and the average number of shoots per explants was 20.1 ± 1.96. For petiole and leaf explants best response was observed on MS supplemented with 2.0 mg/l BAP, 1 mg/l IAA and 0.5 mg/l Kn. Petiole explants produced highest mean number of shoots/explant (22.9 ± 1.728) among the three explants when the explants were cultured on MS with 2.0 mg/l BAP, 1 mg/l IAA and 0.5 mg/l Kn. The highest frequency of root induction (100%) and mean number of roots/plantlets (11.75) were obtained on MS. The rooted plantlets were transferred for hardening following acclimatization and finally were successfully established in the field.Plant Tissue Cult. & Biotech. 27(2): 207-216, 2017 (December)

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Algariri, Khalid, Kuong Y. Meng, Item J. Atangwho, Mohd Z. Asmawi, Amirin Sadikun, Vikneswaran Murugaiyah, and Norhyati Ismail. "Hypoglycemic and anti–hyperglycemic study of Gynura procumbens leaf extracts." Asian Pacific Journal of Tropical Biomedicine 3, no. 5 (May 2013): 358–66. http://dx.doi.org/10.1016/s2221-1691(13)60077-5.

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Journal articles on the topic 'Gynura procumbens'

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