Relevant bibliographies by topics / GYF domain

Academic literature on the topic 'GYF domain'

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Published: 15 June 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "GYF domain":

1

Kofler, Michael M., and Christian Freund. "The GYF domain." FEBS Journal 273, no. 2 (January 2006): 245–56. http://dx.doi.org/10.1111/j.1742-4658.2005.05078.x.

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2

Zhang, Xiaobo, Lei Qin, Junxing Lu, Yunong Xia, Xianyu Tang, Xun Lu, and Shitou Xia. "Genome-Wide Identification of GYF-Domain Encoding Genes in Three Brassica Species and Their Expression Responding to Sclerotinia sclerotiorum in Brassica napus." Genes 14, no. 1 (January 15, 2023): 224. http://dx.doi.org/10.3390/genes14010224.

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GYF (glycine-tyrosine-phenylalanine)-domain-containing proteins, which were reported to participate in many aspects of biological processes in yeast and animals, are highly conserved adaptor proteins existing in almost all eukaryotes. Our previous study revealed that GYF protein MUSE11/EXA1 is involved in nucleotide-binding leucine-rich repeat (NLR) receptor-mediated defense in Arabidopsis thaliana. However, the GYF-domain encoding homologous genes are still not clear in other plants. Here, we performed genome-wide identification of GYF-domain encoding genes (GYFs) from Brassica napus and its parental species, Brassica rapa and Brassica oleracea. As a result, 26 GYFs of B. napus (BnaGYFs), 11 GYFs of B. rapa (BraGYFs), and 14 GYFs of B. oleracea (BolGYFs) together with 10 A. thaliana (AtGYFs) were identified, respectively. We, then, conducted gene structure, motif, cis-acting elements, duplication, chromosome localization, and phylogenetic analysis of these genes. Gene structure analysis indicated the diversity of the exon numbers of these genes. We found that the defense and stress responsiveness element existed in 23 genes and also identified 10 motifs in these GYF proteins. Chromosome localization exhibited a similar distribution of BnaGYFs with BraGYFs or BolGYFs in their respective genomes. The phylogenetic and gene collinearity analysis showed the evolutionary conservation of GYFs among B. napus and its parental species as well as Arabidopsis. These 61 identified GYF domain proteins can be classified into seven groups according to their sequence similarity. Expression of BnaGYFs induced by Sclerotinia sclerotiorum provided five highly upregulated genes and five highly downregulated genes, which might be candidates for further research of plant–fungal interaction in B. napus.
3

Mayya, Vinay K., Mathieu N. Flamand, Alice M. Lambert, Seyed Mehdi Jafarnejad, James A. Wohlschlegel, Nahum Sonenberg, and Thomas F. Duchaine. "microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development." Nucleic Acids Research 49, no. 9 (March 24, 2021): 4803–15. http://dx.doi.org/10.1093/nar/gkab162.

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Abstract microRNA (miRNA)-mediated gene silencing is enacted through the recruitment of effector proteins that direct translational repression or degradation of mRNA targets, but the relative importance of their activities for animal development remains unknown. Our concerted proteomic surveys identified the uncharacterized GYF-domain encoding protein GYF-1 and its direct interaction with IFE-4, the ortholog of the mammalian translation repressor 4EHP, as key miRNA effector proteins in Caenorhabditis elegans. Recruitment of GYF-1 protein to mRNA reporters in vitro or in vivo leads to potent translation repression without affecting the poly(A) tail or impinging on mRNA stability. Loss of gyf-1 is synthetic lethal with hypomorphic alleles of embryonic miR-35–42 and larval (L4) let-7 miRNAs, which is phenocopied through engineered mutations in gyf-1 that abolish interaction with IFE-4. GYF-1/4EHP function is cascade-specific, as loss of gyf-1 had no noticeable impact on the functions of other miRNAs, including lin-4 and lsy-6. Overall, our findings reveal the first direct effector of miRNA-mediated translational repression in C. elegans and its physiological importance for the function of several, but likely not all miRNAs.
4

Kofler, Michael, Kathrin Motzny, Michael Beyermann, and Christian Freund. "Novel Interaction Partners of the CD2BP2-GYF Domain." Journal of Biological Chemistry 280, no. 39 (July 6, 2005): 33397–402. http://dx.doi.org/10.1074/jbc.m503989200.

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5

Mansour, Hala, Alejandro Cabezas-Cruz, Véronique Peucelle, Amaury Farce, Sophie Salomé-Desnoulez, Ines Metatla, Ida Chiara Guerrera, Thomas Hollin, and Jamal Khalife. "Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum." International Journal of Molecular Sciences 24, no. 16 (August 10, 2023): 12647. http://dx.doi.org/10.3390/ijms241612647.

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The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, there is little information about this phosphatase and its regulators in the human malaria parasite, Plasmodium falciparum. To address this knowledge gap, we conducted a comprehensive investigation into the structural and functional characteristics of a conserved Plasmodium-specific regulator called Gametocyte EXported Protein 15, GEXP15 (PF3D7_1031600). Through in silico analysis, we identified three significant regions of interest in GEXP15: an N-terminal region housing a PP1-interacting RVxF motif, a conserved domain whose function is unknown, and a GYF-like domain that potentially facilitates specific protein–protein interactions. To further elucidate the role of GEXP15, we conducted in vitro interaction studies that demonstrated a direct interaction between GEXP15 and PP1 via the RVxF-binding motif. This interaction was found to enhance the phosphatase activity of PP1. Additionally, utilizing a transgenic GEXP15-tagged line and live microscopy, we observed high expression of GEXP15 in late asexual stages of the parasite, with localization predominantly in the nucleus. Immunoprecipitation assays followed by mass spectrometry analyses revealed the interaction of GEXP15 with ribosomal- and RNA-binding proteins. Furthermore, through pull-down analyses of recombinant functional domains of His-tagged GEXP15, we confirmed its binding to the ribosomal complex via the GYF domain. Collectively, our study sheds light on the PfGEXP15–PP1–ribosome interaction, which plays a crucial role in protein translation. These findings suggest that PfGEXP15 could serve as a potential target for the development of malaria drugs.
6

Kofler, Michael, Kathrin Motzny, and Christian Freund. "GYF Domain Proteomics Reveals Interaction Sites in Known and Novel Target Proteins." Molecular & Cellular Proteomics 4, no. 11 (August 23, 2005): 1797–811. http://dx.doi.org/10.1074/mcp.m500129-mcp200.

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7

Albert, Gesa I., Christoph Schell, Karin M. Kirschner, Sebastian Schäfer, Ronald Naumann, Alexandra Müller, Oliver Kretz, et al. "The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function." Journal of Molecular Cell Biology 7, no. 5 (June 16, 2015): 402–14. http://dx.doi.org/10.1093/jmcb/mjv039.

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8

Gu, Wei, Michael Kofler, Iris Antes, Christian Freund, and Volkhard Helms. "Alternative Binding Modes of Proline-Rich Peptides Binding to the GYF Domain†." Biochemistry 44, no. 17 (May 2005): 6404–15. http://dx.doi.org/10.1021/bi0479914.

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9

Opitz, Robert, Matthias Müller, Cédric Reuter, Matthias Barone, Arne Soicke, Yvette Roske, Kirill Piotukh, et al. "A modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions." Proceedings of the National Academy of Sciences 112, no. 16 (April 6, 2015): 5011–16. http://dx.doi.org/10.1073/pnas.1422054112.

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Small-molecule competitors of protein–protein interactions are urgently needed for functional analysis of large-scale genomics and proteomics data. Particularly abundant, yet so far undruggable, targets include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3), WW, GYF, and Drosophila enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) homology 1 (EVH1) domains. Here, we present a modular strategy to obtain an extendable toolkit of chemical fragments (ProMs) designed to replace pairs of conserved prolines in recognition motifs. As proof-of-principle, we developed a small, selective, peptidomimetic inhibitor of Ena/VASP EVH1 domain interactions. Highly invasive MDA MB 231 breast-cancer cells treated with this ligand showed displacement of VASP from focal adhesions, as well as from the front of lamellipodia, and strongly reduced cell invasion. General applicability of our strategy is illustrated by the design of an ErbB4-derived ligand containing two ProM-1 fragments, targeting the yes-associated protein 1 (YAP1)-WW domain with a fivefold higher affinity.
10

Kofler, Michael, Katja Heuer, Tobias Zech, and Christian Freund. "Recognition Sequences for the GYF Domain Reveal a Possible Spliceosomal Function of CD2BP2." Journal of Biological Chemistry 279, no. 27 (April 22, 2004): 28292–97. http://dx.doi.org/10.1074/jbc.m402008200.

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You might also be interested in the extended bibliographies on the topic 'GYF domain' for particular source types:
Journal articles Dissertations / Theses

Dissertations / Theses on the topic "GYF domain":

1

Georgiev, Alexander. "Membrane Stress and the Role of GYF Domain Proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7764.

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2

Albert, Gesa Ines [Verfasser]. "Functional characterization of GYF-domain containing proteins / Gesa Ines Albert." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026695856/34.

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3

Mansour, Hala. "Characterization of GEXP15 as a potential regulator of protein phosphatase 1 in Plasmodium falciparum." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS068.

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Le paludisme est l'une des maladies infectieuses les plus répandues, menaçant 40% de la population mondiale, provoquant environ 300 millions de cas et 450 000 décès chaque année, touchant principalement les enfants de moins de 5 ans. En l'absence d'un vaccin efficace et face à l'émergence de la résistance aux médicaments, il y a un besoin urgent pour mieux comprendre la biologie du parasite afin de proposer des traitements innovants. Le parasite du paludisme, Plasmodium, responsable de la maladie, présente un cycle de vie complexe et un processus de division cellulaire unique. Par rapport aux systèmes bien étudiés, la connaissance limitée de la biologie du Plasmodium empêche le développement thérapeutique. La phosphorylation des protéines, un mécanisme de régulation important, est moins comprise dans Plasmodium que dans les cellules mammifères ou de levure. Les kinases et les phosphatases impliquées dans la phosphorylation et la déphosphorylation respectivement sont des cibles potentielles de médicaments. La sous-unité catalytique de la protéine phosphatase de type 1 (PP1c) (PF3D7_1414400) opère en combinaison avec diverses protéines régulatrices pour diriger et contrôler spécifiquement son activité phosphatase. Cependant, peu d'informations sont disponibles sur cette phosphatase et ses régulateurs dans le parasite du paludisme humain, Plasmodium falciparum. Pour combler cette lacune de connaissances, nous avons mené une étude approfondie sur les caractéristiques structurelles et fonctionnelles d'un régulateur spécifique du Plasmodium appelé, Gametocyte EXported Protein 15, GEXP15 (PF3D7_1031600). Par analyses in silico, nous avons identifié trois régions d'intérêt significatives dans GEXP15 : une région N-terminale couvrant un motif RVxF interagissant avec PP1, un domaine conservé dont la fonction est inconnue, et un domaine de type GYF qui facilite potentiellement des interactions spécifiques protéine-protéine. Pour élucider davantage le rôle de GEXP15, nous avons réalisé des études d'interaction in vitro qui ont démontré une interaction directe entre GEXP15 et PP1 via le motif de liaison RVxF. Cette interaction avec PfGEXP15 a été montrée capable d'augmenter l'activité phosphatase de PP1 in vitro. De plus, en utilisant une lignée transgénique de P. falciparum exprimant la GEXP15-GFP, nous avons observé une forte expression de GEXP15 dans les stades asexués tardifs du parasite, avec une localisation principalement dans le noyau. Des expériences d'immunoprécipitation suivies d'analyses en spectrométrie de masse ont révélé l'interaction de GEXP15 avec des protéines de liaison aux ribosomes et à l'ARN. De plus, grâce à des analyses de capture de domaines fonctionnels recombinants de GEXP15 marqués avec un tag His, nous avons confirmé sa liaison avec PfPP1et au complexe ribosomal via le domaine GYF. Dans l'ensemble, notre étude éclaire l'interaction PfGEXP15-PP1-ribosome, qui joue un rôle crucial dans la traduction des protéines. Ces découvertes suggèrent que PfGEXP15 pourrait être une cible potentielle pour le développement de médicaments contre le paludisme
Malaria is one of the most prevalent vector-borne infectious diseases threatening 40% of the global population, causing around 300 million cases and 450,000 deaths annually, mostly affecting children under 5. With no effective vaccine and drug resistance emerging, there is an urgent need for innovative treatments. The malaria-causing Plasmodium parasite has a complex life cycle and unique cell division process. Compared to well-studied systems, limited knowledge of Plasmodium biology hampers therapeutic development. Protein phosphorylation, a key regulatory mechanism, is less understood in Plasmodium than in mammalian or yeast cells. Kinases and phosphatases involved in phosphorylation and dephosphorylation processes respectively are potential drug targets. The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, there is little information about this phosphatase and its regulators in the human malaria parasite, Plasmodium falciparum. To address this knowledge gap, we conducted a comprehensive investigation into the structural and functional characteristics of a conserved Plasmodium-specific regulator called Gametocyte EXported Protein 15, GEXP15 (PF3D7_1031600). Through in silico analysis, we identified three significant regions of interest in GEXP15: an N-terminal region hous-ing a PP1-interacting RVxF motif, a conserved domain whose function is unknown, and a GYF-like domain that potentially facilitates specific protein-protein interactions. To further elucidate the role of GEXP15, we conducted in vitro interaction studies that demonstrated a direct interaction between GEXP15 and PP1 via the RVxF-binding motif. This interaction was found to enhance the phosphatase activity of PP1. Additionally, utilizing a transgenic GEXP15-tagged line and live microscopy, we observed high expression of GEXP15 in late asexual stages of the parasite, with localization predominantly in the nucleus. Immunoprecipitation assays followed by mass spectrometry analyses revealed the interaction of GEXP15 with ribosomal- and RNA-binding proteins. Furthermore, through pull-down analyses of recombinant functional domains of His-tagged GEXP15, we confirmed its binding to PfPP1 and to the ribosomal complex via the GYF domain. Collectively, our study sheds light on the PfGEXP15-PP1-ribosome interaction, which plays a crucial role in protein translation. These findings suggest that PfGEXP15 could serve as a potential target for the development of malaria drugs
4

Kofler, Michael. "GYF domains a class of proline rich ligand binding adaptor domains /." kostenfrei, 2007. http://www.diss.fu-berlin.de/2007/261/index.html.

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5

Sekharan, Monica R. "Structural studies of the cGMP-binding GAF domain of PDE5A /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.

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6

Lee, Hyung Suk 1971. "Proximity of body & mind : urban gym as a heterotopic domain." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/68380.

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Abstract:
Thesis (M.Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 2002.
Includes bibliographical references (p. 78-79).
In the present urban space, where an individual is exposed to the conditions of heterogeneity and anonymity, a conventional Bodybuilding Gym opens up certain issues of emplacement of un/nder-spoken men's body and its close(t)ed placement in the society. While the rituals of entering and exiting the gym and 'building' the muscularity raise questions of men's reflected societal states in North America, the changing social appreciation of the 'new' body images, and emerging holistic approach of wellness of body-mind have become the thresholds to rethink the previously hyper-masculine gym space and to reinvent a way to accommodate these new conditions. I have explored the design of a contemporary gym as a subterranean-heterotopic- site rooted in the current urban context to reflect its various and changing socio-spatial identities of each user. The design focus is to recognize the updated characteristics of the user spaces when the gym is introduced with the new programs of Totality of Body-Mind, or, a further embodied Mind Zone coming into the body activity program concepts, to create new physical and psychological inter-relationships, or Proximity of Heterotopic Stages, to the individual users.
by Hyung Suk Lee.
M.Arch.
7

Alharbi, Mona. "Structural investigation of the GAF domain protein BPSL2418 from Burkholderia pseudomallei." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8314/.

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A new family of methionine-sulfoxide reductase (Msr) was recently discovered, and was named free methionine sulfoxide reductase (fRMsr). This family includes enzymes with a reductase activity toward the free R isomer of a methionine sulfoxide substrate. The fRMsrs have a GAF domain topology, a domain, which was previously identified as having in some cases a cyclic nucleotide phosphodiesterase activity. The classification of fRMsrs as GAF domains revealed a new function can be added to the GAF domain family. Interestingly the four members identified in the fRMsr family share the GAF domain structure and the presence of three conserved cysteines in the active site with free R methionine sulfoxide substrate specificity. This thesis presents the crystal structures of reduced, free Met-SO substrate-bound and MES-bound forms of a new fRMsr from Burkholderia pseudomallei (BPSL2418). BPSL2418 was cloned, overexpressed and purified to enable protein crystallization. The crystallization trials for reduced, Met-SO-bound and MES-bound forms of BPSL2418 were prepared and reasonable crystals of each form were produced. The crystal structures of BPSL2418MES, BPSL2418Met-SO and BPSL2418Reduced were solved at 1.18, 1.4 and 2.0Å, respectively by molecular replacement. The BPSL2418MES crystal belongs to space group P 21 21 21 while BPSL2418Met-SO and BPSL2418Reduced crystals belong to space group P 1 21 1. All three forms share the GAF domain structure of six antiparallel β-strands and four a-helices with connecting loops. The antiparallel β- strands (β1, β2, β5 and β6) are located in the center of the BPSL2418 structure flanked on one side by a three a-helices (a1, a2 and a4) and on the other side by a (loop1, β3, loop2, a3, β4 loop4) unit where loop4 forms a capping flap and covers the active site. The structural comparison of the three forms of BPSL2418 indicates that the catalytically important cysteine is CYS109, where the resolving cysteine is CYS75, which forms a disulfide bond with CYS109. They also suggest that the third conserved cysteine in the active site, CYS85, which is located in a3, is a nonessential cysteine for the catalytic function but it may play a role in the binding of the substrate. The structural comparison of the three forms reveals that conformational changes appear in the active site particularly involving loop4 and CYS109 during catalysis. The 3D structure of BPSL2418 shows strong structure similarity to fRMsrs enzymes, which further suggests that BPSL2418 acts as a free Met-R-SO reductase and shares the catalytic mechanism of fRMsr family.
8

Libiad, Marouane. "La free R Méthionine sulfoxyde réductase (fRMsr) de Neisseria meningitidis : Mécanisme, catalyse et spécificité structurale." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0335/document.

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Les Méthionine sulfoxyde réductases (Msr) catalysent la réduction spécifique des méthionine sulfoxydes (Met-O) en méthionines (Met). Elles sont impliquées dans la résistance des cellules à un stress oxydant et dans la virulence des bactéries pathogènes du genre Neisseria. Cette famille d'enzyme se compose de trois classes, les MsrA et B, structuralement distinctes, et présentant une stéréosléctivité respectivement pour l'isomère S et R de la fonction sulfoxyde du substrat. Une troisième classe, découverte récemment, et appelée fRMsr, catalyse la réduction spécifique de la forme libre de l'isomère R de la fonction sulfoxyde. La fRMsr appartient à la famille des domaines GAF, généralement impliqués dans la signalisation cellulaire, et les fRMsr représentent le premier domaine GAF présentant une activité enzymatique. Les études réalisées au cours de ma thèse sur la fRMsr de Neisseria meningitidis ont permis de montrer que : 1) fRMsr de N. meningitidis présente un mécanisme catalytique identique à MsrA/B avec la formation d'au moins un pont disulfure intramoléculaire Cys84-Cys118 réduit par la thiorédoxine (Trx) ; 2) La Cys118 est le résidu catalytique sur lequel l'intermédiaire acide sulfénique doit se former ; 3) L'étape réductase est l'étape cinétiquement déterminante du mécanisme à deux étapes conduisant à la formation du pont disulfure Cys84-Cys118. La combinaison de l'analyse des résultats cinétiques, et de la structure tridimensionnelle de la fRMsr de N. meningitidis en complexe avec le substrat ont permis de montrer : 1) L'existence d'un site de reconnaissance oxyanion impliqué dans la stabilisation de la fonction carboxylate ; 2) Un rôle de la fonction carboxylate du résidu Asp143 dans la catalyse de l'étape réductase ; 3) Le résidu Glu125 est impliqué dans la reconnaissance et/ou le positionnement du substrat Met-O probablement via la stabilisation du groupement NH3+ ; 4) Un rôle du résidu Asp141 dans le positionnement des résidus Asp143 et Glu125 ; 5) le noyau indole du Trp62 est impliqué dans la stabilisation du groupe méthyle-[epsilon]
Methionine sulfoxide reductases (Msr) catalyze the specific reduction of methionine sulfoxides (Met-O) into methionine (Met). They are involved in cell defences against oxidative stress and virulence of pathogenic bacteria of Neisseria genius. This family of enzymes consists of three classes, MsrA and MsrB, structurally-unrelated, Specific for the S and the R epimer of the sulfoxide function of the substrate, respectively. A third class, recently discovered and called fRMsr, selectively reduce the free form of the R epimer of the sulfoxide function. The fRMsr belongs to the family of GAF domains, they are usually involved in cell signaling, and fRMsr represent the first GAF domain to show enzymatic activity. The studies of the Neisseria meningitidis fRMsr have shown that: 1) The Neisseria meningitidis fRMsr have a identical catalytic mechanism to MsrA and MsrB with the formation of at least one intramolecular disulfide bond, Cys84-Cys118 reduced by thioredoxin (Trx) ; 2) The Cys118 is demonstrated to be the catalytic Cys on which a sulfenic acid is formed ; 3) The Reductase step is the rate determining step of the mechanism leading to the formation of the disulfide bond Cys84-Cys118. The combination of the biochemical and kinetics data, and the examination of the 3D structure of the N. meningitidis fRMsr in complex with its substrate shown: 1) an oxyanion hole involved in the accommodation of the carboxylate group ; 2) the carboxylate group of the Asp143 residue involved in the catalysis of step reductase, and 3) The Glu125 residue involved in the recognition and/or positioning of the Met-O probably by the stabilization of the NH3+; 4) the Asp141 residue involved in the positioning of Asp143 and Glu125 residues ; 5) the indole ring of the Trp62 residue involved in stabilizing of the epsilon-methyl group
9

Rao, Shuyun. "Vav3 Potentiation of Androgen Receptor Activity in Prostate Cancer." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/359.

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Most patients undergoing androgen deprivation therapy relapse eventually and progress to androgen-independent (AI) prostate cancer. Although the mechanisms underlying progression to AI prostate cancer are not well understood, studies suggest that androgen receptor (AR) is still required for AI prostate cancer. Our lab found that Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is up-regulated during the progression of androgen-dependent human prostate cancer cells to androgen-independence in vivo and in cell-based experiments. Since Vav3 significantly increases ligand-dependent AR transcriptional activity and this action requires the Vav3 pleckstrin homology (PH) domain but not Vav3 GEF activity, we explored the role of the Vav3 PH domain in ligand-dependent AR coactivation by Vav3. We found that targeting the Vav3 PH mutant into nuclei but not the plasma membrane restored Vav3 PH mutant in AR coactivation. Targeting Vav3 to the plasma membrane eliminated the capacity of Vav3 to coactivate AR. In agreement with nuclear targeting of Vav3 via its PH domain, chromatin immunoprecipitation assays showed that Vav3 enhancement of AR transcriptional activity was accompanied by Vav3 recruitment to AR transcriptional complexes at an AR target gene enhancer. Further, Vav3 increased AR occupancy at the target gene enhancer upon androgen treatment and this may underlie the capacity of Vav3 to enhance AR transcriptional activity. Because Vav3 can also be activated by growth factors (GFs) and GFs activate AR in the absence of androgen (ligand-independent), we investigated the crosstalk between Vav3 and GF activation of AR and found Vav3 strongly enhanced AR transcriptional activity induced by GFs. GEF function and the downstream Rho GTPase, Rac1 were required for constitutively active (Ca) Vav3 activation of AR, which differs from Vav3 activation of AR in the presence of androgen. We also investigated the possible signal pathways contributing to AR activation by Ca Rac1. Ca Rac1 caused ligand-independent activation of AR in part through MAPK/ERK signaling and conferred prostate cancer growth in the absence of androgen in cell culture, soft agar and mouse tumor xenografts. Thus, our findings indicate that Vav3 activates AR in the presence or absence of ligand through two distinct mechanisms, which supports a versatile regulatory effect of Vav3 in AR signaling and prostate cancer progression.
10

Wu, Albert Ya-Po. "Molecular mechanism of cyclic nucleotide binding to the GAF domains of phosphodiesterases 2 and 5 /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5012.

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Books on the topic "GYF domain":

1

Bod-rang-skyong-ljongs ʼphel rgyas dang sgyur bcos u yon lhan khang. Gzhung lam gyi bdag dbang ham bzung dang gtor skyon btang bar skyin tshab (gun gsab) gron dngul bsdu phyogs kyi rnam grangs dang tshad gzhiʼi skor gyi brda tho: Bod ʼphel sgyur rin gong [2009] ang 651 pa. [Tibet]: Bod-rang-skyong-ljongs ʼgrim ʼgrul thing gzhung lam do dam cus nas par du skrun, 2009.

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Naron, Josie. Columbia University's 'Gym Crow' and the Politics of Public Space: A Zine. Brooklyn, NY: the author, 2018.

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US GOVERNMENT. 21st Century Collection of National War College Military Image Clipart with nearly 20,000 Public Domain Images in JPG and GIF Formats: Army, Navy, Air ... More (Core Federal Information Series). Progressive Management, 2003.

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Book chapters on the topic "GYF domain":

1

Freund, Christian. "The GYF Domain." In Modular Protein Domains, 103–16. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527603611.ch5.

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Ryan, Robert P., Yvonne McCarthy, and J. Maxwell Dow. "The HD-GYP Domain and Cyclic Di-GMP Signaling." In The Second Messenger Cyclic Di-GMP, 57–67. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555816667.ch5.

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Schultz, Joachim E., Torsten Dunkern, Elvira Gawlitta-Gorka, and Gabriele Sorg. "The GAF-Tandem Domain of Phosphodiesterase 5 as a Potential Drug Target." In Phosphodiesterases as Drug Targets, 151–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17969-3_6.

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Gorski, Jerome L. "FGD1 and Faciogenital Dysplasia (Aarskog–Scott Syndrome)." In Inborn Errors Of Development, 1289–98. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0145.

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Abstract FGD1 mutations result in faciogenital dysplasia (FGDY; Aarskog–Scott syndrome), an X-linked recessive multiple congenital anomaly syndrome. Skeletal anomalies dominate the FGDY phenotype. Cardinal clinical features include a characteristic set of craniofacial and skeletal anomalies, disproportionate acromelic short stature, delayed skeletal maturation, and urogenital malformations. FGD1 encodes a guanine nucleotide exchange factor (GEF) that speci’cally activates Cdc42, a Rho guanosine triphosphatase (GTPase) that is involved in cell signaling and the regulation of the actin cytoskeleton, vesicular transport, and gene expression. The FGD1 protein is composed of multiple signaling motifs including a Src homology 3–binding domain, a GEF domain, a zinc-’nger FYVE domain, and two pleckstrin homology (PH) domains. By activating Cdc42, FGD1 stimulates cells to reorganize their actin cytoskeleton and form ‘lopodia, cytoskeletal elements involved in cellular signaling, adhesion, and migration. Through Cdc42, FGD1 also activates the c-Jun N-terminal kinase (JNK) signaling cascade, a pathway that regulates cell growth, apoptosis, and cellular differentiation.
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Semenza, Gregg L. "POU Domain Proteins." In Transcription Factors and Huinan Disease, 261–71. Oxford University PressNew York, NY, 1998. http://dx.doi.org/10.1093/oso/9780195112399.003.0011.

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Abstract Homeodomain transcription factors play essential roles in controlling embryonic development in all animal species studied. Within the super family of homeodomain factors is the POU domain family, which was established on the basis of amino acid sequence homology between the transcription factors ;EITl/GHFl, OCTl, OCT2, and !JNC86 (hence the acronym POU, which is pronounced “pow”) (Herr et al., 1988). PITl/ GHF (Bodner et al., 1988; Ingraham et al., 1988) controls transcription of the growth hormone and other pituitary-specific genes, OCTl (Sturm et al., 1988) is ubiquitously expressed and activates transcription of histone H2B genes, OCT2 (Clerc et al., 1988; Ko et al., 1988) activates transcrip tion of immunoglobulin genes in B lymphocytes, and UNC86 (Finney et al., 1988) determines neuroblast fate in C.elegans. Subsequently, over two dozen POU domain-containing proteins have been identified in C. elegans, Drosophila, and mammals (Verrijzer and Van der Vliet, 1993). A new system of genetic nomenclature has been devised so that the PITl/ GHFl, OCTl, OCT2, and BRN4/OCT9 proteins are encoded by POU1F1, POU2F1, POU2F2, and POU3F4, respectively (reviewed by Ezzell, 1996). The defining characteristic of POU proteins is a bipartite DNA binding domain of 150 to 160 amino acids that consists of a 60-amino acid POU homeodomain (POUH0) located just carboxyl-terminal to a POU-specific domain (POU5) of 70 to 80 amino acids (Fig. 11.1). As described in Chapter 9, the homeodomain contains three a-helical regions so that helices 2 and 3 form a helix-turn-helix motif that is structurally similar to the DNA-binding domain of prokaryotic repressors, in which helix 3 contacts DNA in the major groove (Harrison and Aggar wal, 1990). The POU5 domain contains four a-helical regions so that hel ices 2 and 3 form a helix-turn-helix motif that is similar in its structure to the phage A repressor DNA-binding domain (Assa-Munt et al., 1993).
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Martinez, Sergio E., Xiao-Bo Tang, Stewart Turley, Wim G. J. Hol, and Joseph A. Beavo. "Cyclic Nucleotide-Binding Phosphodiesterase and Cyclase GAF Domains." In Handbook of Cell Signaling, 525–29. Elsevier, 2003. http://dx.doi.org/10.1016/b978-012124546-7/50568-4.

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Martinez, Sergio E., Clemens C. Heikaus, and Joseph A. Beavo. "Cyclic Nucleotide-Binding GAF Domains in Phosphodiesterases and Adenylyl Cyclases." In Handbook of Cell Signaling, 1531–36. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-12-374145-5.00187-x.

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Ahn, Jae-Hyeon, and Suk-Gwon Chang. "Managing Healthcare Organizations through the Knowledge Productivity Measurement." In Creating Knowledge-Based Healthcare Organizations, 286–303. IGI Global, 2005. http://dx.doi.org/10.4018/978-1-59140-459-0.ch021.

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Understanding the contribution of knowledge to business performance is important for efficient resource allocations. It is very true for healthcare organizations. For the best utilization of scare medical expertise in the successful medical service delivery process, knowledge management will play a more important role in the future. In this paper, a performance-oriented knowledge management methodology or KP3 methodology was applied to the medical domain. Through actual data from the six OB/GYN specialty hospitals in Korea, the contribution of knowledge to performance was assessed. Specifically, the productivities of knowledge entities were calculated using DEA (Data Envelopment Analysis) approach to give some important managerial insights for knowledge management activities.
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Fiege, Kerstin, Christian Twittenhoff, Kathrin Kwiatkowski, and Nicole Frankenberg-Dinkel. "Spectroscopic characterization of the heme binding (GAF) domain of two sensor kinases from Methanosarcina acetivorans." In Porphyrin Science by Women, 1265–78. WORLD SCIENTIFIC, 2021. http://dx.doi.org/10.1142/9789811223556_0113.

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El Rahman Hassoun, Abed, Ivana Ujević, Milad Fakhri, Romana Roje-Busatto, Céline Mahfouz, Sharif Jemaa, and Nikša Nazlić. "Biotoxins in the Mediterranean Sea: Lebanon as a Case Study." In Environmental Pollutants in the Mediterranean Sea: Recent Trends and Remediation Approaches, 1–43. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815179064123010003.

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Marine biotoxins are naturally occurring chemicals produced by toxic algae. They can be found in seawater and can accumulate in various marine organisms, such as commercial seafood. When contaminated seafood is consumed, these biotoxins can cause poisoning in humans, with varying health consequences depending on the type and amount of toxins. The proliferation of biotoxin-producing algae in the marine environment has dire socio-economic and environmental consequences due to the contamination of water and seafood. Due to the number of factors related to human pressures and climate change impacts, the frequency of marine biotoxins’ occurrence is increasing significantly globally, and in regional seas such as the Mediterranean Sea. In this chapter, we highlight Lebanon in the Eastern Mediterranean Sea, where marine biotoxins were recently studied. The results show for the first time the presence of lipophilic toxins and cyclic imines in marine biota, with values for okadaic acid, dinophysistoxin 1 and 2, pectenotoxin 1 and 2, yessotoxins and azaspiracids below the detection limit (LOD). Levels above LOD were detected for domoic acid (DA), gymnodimine (GYMb), and spirolides (SPXs) in some species/areas. Maximum levels of DA, GYM, and SPXs (3.88 mg DA kg-1, 102.9 µg GYM kg-1, 15.07 µg SPX kg-1) were found in the spiny oyster (Spondylus spinosus) in agreement with the occurrence of Pseudo-nitzchia spp, Gymndinium spp, and Alexandrium spp. DA was below the EU limit but above the lowest observed adverse effect level (0.9 μg g-1) for neurotoxicity in humans and below the acute reference dose (30 µg kg-1 body weight), both established by EFSA. Considering the lowest lethal dose (LD50) after administration of GYM and SPXs to mice, it is unlikely that there is a health risk due to exposure to these toxins from seafood consumption in Lebanon. Nevertheless, the chronic toxicity of DA, GYMs, and SPXs remains unclear, and the effects of repeated consumption of contaminated seafood need to be investigated. Because biotoxins have been detected in bivalves and commercial species, as well as other organisms in the marine trophic chain, it is evident that species other than bivalves should be monitored, and the spiny oyster (S. spinosus) may play the role of a sentinel species in biotoxin studies. A regular monitoring program is needed to provide reliable, accurate estimates of bloom toxicity and to investigate their potential impact on marine species and human health in Lebanon.

Conference papers on the topic "GYF domain":

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Philippe, Maxime, Bruno Borgarino, Panagiotis Kotronis, and Guillaume Ducrozet. "An Integrated Approach for the Representation of Concrete Gravity Based Foundations for Offshore Wind Turbines." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10639.

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This paper describes a novel approach to efficiently simulate the structural dynamics of a concrete Gravity Based Foundation (GBF). In this time-domain analysis, the GBF is subjected to loads applied by the turbine, wave loads and the influence of the soil structure interaction is taken into account. Wind turbine loads are computed using the aeroelastic software FAST and expressed at the connection point between the turbine and the GBF Wave loads on the GBF are computed using a potential, nonlinear wave model. Nonlinear soil-structure interaction is modelled with the use of a macro-element specifically developed for shallow foundations. Finally, the structure itself is modelled using an Euler-Bernoulli multifiber beam, which allows representing the reinforced concrete sections. It is shown that the numerical model is able to efficiently simulate the behaviour of a GBF foundation under nonlinear irregular wave forces and loads transmitted by the turbine. It reproduces nonlinear phenomena such as a decrease in material stiffness due to damage and permanent strains but also the GBF displacements considering soil structure interaction.
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Bhat, Sandesh G., Thomas G. Sugar, and Sangram Redkar. "Reconstruction of Ground Reaction Force Data Using Lyapunov Floquet Theory and Invariant Manifold Theory." In ASME 2020 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/detc2020-22521.

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Abstract Ground Reaction Force (GRF) is an essential gait parameter. GRF analysis provides important information regarding various aspects of gait. GRF has been traditionally measured using bulky force plates within lab environments. There exist portable force sensing units, but their accuracy is wanting. Estimation of GRF has applications in remote wearable systems for rehabilitation, to measure performance in athletes, etc. This article explores a novel method for GRF estimation using the Lyapunov-Floquet (LF) and invariant manifold theory. We assume human gait to be a periodic motion without external forcing. Using time delayed embedding, a reduced order system can be reconstructed from the vertical GRF data. LF theory can be applied to perform system identification via Floquet Transition Matrix and the Lyapunov Exponents. A Conformal Map was generated using the Lyapunov Floquet Transformation that maps the original time periodic system on a linear Single Degree of Freedom (SDoF) oscillator. The response of the oscillator system can be calculated numerically and then remapped back to the original domain to get GRF time evolution. As an example, the GRF data from an optical motion capture system for two subjects was used to construct the reduced order model and system identification. A comparison between the original system and its reduced order approximation showed good correspondence.
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Hage, Ilige S., Charbel Y. Seif, Ré-Mi Hage, and Ramsey F. Hamade. "A Verified Non-Linear Regression Model for Elastic Stiffness Estimates of Finite Composite Domains Considering Combined Effects of Volume Fractions, Shapes, Orientations, Locations, and Number of Multiple Inclusions." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-86231.

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A non-linear regression model using SAS/STAT (JMP® software; Proc regression module) is developed for estimating the elastic stiffness of finite composite domains considering the combined effects of volume fractions, shapes, orientations, inclusion locations, and number of multiple inclusions. These estimates are compared to numerical solutions that utilized another developed homogenization methodology by the authors (dubbed the generalized stiffness formulation, GSF) to numerically determine the elastic stiffness tensor of a composite domain having multiple inclusions with various combinations of geometric attributes. For each inclusion, these considered variables represent the inclusions’ combined attributes of volume fraction, aspect ratio, orientation, number of inclusions, and their locations. The GSF methodology’s solutions were compared against literature-reported solutions of simple cases according to such well-known techniques as Mori-Tanaka and generalized self-consistent type methods. In these test cases, the effect of only one variable was considered at a time: volume fraction, aspect ratio, or orientation (omitting the number and locations of inclusions). For experimental corroboration of the numerical solutions, testing (uniaxial compression) was performed on test cases of 3D printed test cubes. The regression equation returns estimates of the composite’s ratio of normalized longitudinal modulus (E11) to that of the matrix modulus (Em) or E11/Em when considering any combination of all of the aforementioned inclusions’ variables. All parameters were statistically analyzed with the parameters retained are only those deemed statistically significant (p-values less than 0.05). Values returned by the regression stiffness formulation solutions were compared against values returned by the GSF formulation numerical and against the experimentally found stiffness values. Results show good agreement between the regression model estimates as compared with both numerical and experimental results.
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Chinimilli, Prudhvi Tej, Sean Wolfgang Wachtel, Panagiotis Polygerinos, and Wenlong Zhang. "Hysteresis Compensation for Ground Contact Force Measurement With Shoe-Embedded Air Pressure Sensors." In ASME 2016 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/dscc2016-9920.

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This paper reviews the design of smart shoes, a wearable device that measures ground contact forces (GCFs) for gait analysis. Smart shoes utilize four coils of silicone tubes adhered directly underneath the shoe insole at key points of interest. Air pressure sensors connect to each tube coil to measure pressure changes caused by compression. This paper presents static and dynamic calibration performed on each sensing coil to establish a model of internal pressure and the GCF. Based on the model, a phase lead filter is designed to account for the hysteresis effect and visco-elastic properties of the silicone tube in order to provide accurate GCF measurements. To design this filter, the air bladder is modeled using a standard linear solid (SLS) model. The prediction error minimization (PEM) algorithm is then implemented to identify the continuous-time transfer function of this SLS model, which is then transformed to discrete time domain to implement in a digital processor. Mechanical characterization and testing on a healthy subject are performed to validate the model and its capability to compensate for hysteresis in GCF measurement.
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Gandotra, Rahil, and Levi Perigo. "GPF: A Green Power Forwarding Technique for Energy-Efficient Network Operations." In 2nd International Conference on Machine Learning Techniques and Data Science (MLDS 2021). Academy and Industry Research Collaboration Center (AIRCC), 2021. http://dx.doi.org/10.5121/csit.2021.111808.

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The energy consumption of network infrastructures is increasing; therefore, research efforts designed to diminish this growing carbon footprint are necessary. Building on prior work, which determined a difference in the energy consumption of network hardware based on their forwarding configurations and developed a real-time network energy monitoring tool, this research proposes a novel technique to incorporate individual device energy efficiency into network routing decisions. A new routing metric and algorithm are presented to select the lowest-power, least-congested paths between destinations, known as Green Power Forwarding (GPF). In addition, a network dial is developed to enhance GPF by allowing network administrators to tune the network to optimally operate between energy savings and network performance. To ensure the scope of this research for industry adoption, implementation details for different generations of networking infrastructure (past, present, and future) are also discussed. The experiment results indicate that significant energy and, in turn, cost savings can be achieved by employing the proposed GPF technique without a reduction in network performance. The future directions for this research include developing dynamically-tuning network dial modes and extending the principles to inter-domain routing.
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Tinkl-Hennighausen, Fabian. "Leveraging the Benefits of Big Data and AI at Siemens: The Critical Role of Data Mesh and Domain Orientation." In Genetoberfest 2023. ScienceOpen, 2023. http://dx.doi.org/10.14293/gof.23.05.

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Uslan, Volkan, and Huseyin Seker. "Binding affinity prediction of S. cerevisiae 14-3-3 and GYF peptide-recognition domains using support vector regression." In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2016. http://dx.doi.org/10.1109/embc.2016.7591469.

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van Wijngaarden, Martijn, Piet Meijers, Tim Raaijmakers, Richard de Jager, and Kenneth Gavin. "Gravity Based Foundations for Offshore Wind Turbines: Cyclic Loading and Liquefaction." In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-77082.

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In current modelling of excess pore pressures (EPPs) below marine structures, the irregular nature of cyclic loads and the real storm development are not taken into account. The effect of the irregular cyclic loading in time is investigated in this paper. The wind, wave and turbine loads on a gravity based foundation (GBF) are derived in the frequency domain. The real storm development is based on the CoastDat dataset. The load input is used in a program which takes the generation and dissipation of pore pressures under cyclic loading into account. Also, densification is included. The results show that the first storm in the lifetime of the GBF results in the highest EPPs. The EPP decreases in time, due to significant dissipation and densification during the build-up of a storm. Therefore, not the storms with the largest cyclic loads but the storms with the fastest build-up result in the highest EPPs, since this limits the process of densification. A large scatter is found in the maximum values of EPPs due to the irregular nature of the loads.
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Wymeersch, H., H. Steendam, and M. Moeneclaey. "Log-domain decoding of LDPC codes over GF(q)." In 2004 IEEE International Conference on Communications (IEEE Cat. No.04CH37577). IEEE, 2004. http://dx.doi.org/10.1109/icc.2004.1312606.

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Xiang, Yujiang. "Muscle Force Prediction of 2D Gait Using Predictive Dynamics Optimization." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59107.

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Cyclic human gait is simulated in this work by using a 2D musculoskeletal model with 12 degrees of freedom (DOF). Eight muscle groups are modeled on each leg. Predictive dynamics approach is used to predict the walking motion. In this process, the model predicts joints dynamics and muscle forces simultaneously using optimization schemes and task-based physical constraints. The results indicated that the model can realistically match human motion, ground reaction forces (GRF), and muscle force data during walking task. The proposed optimization algorithm is robust and the optimal solution is obtained in seconds. This can be used in human health domain such as leg prosthesis design.

Reports on the topic "GYF domain":

1

Kibler, Amanda, René Pyatt, Jason Greenberg Motamedi, and Ozen Guven. Key Competencies in Linguistically and Culturally Sustaining Mentoring and Instruction for Clinically-based Grow-Your-Own Teacher Education Programs. Oregon State University, May 2021. http://dx.doi.org/10.5399/osu/1147.

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Grow-Your-Own (GYO) Teacher Education programs that aim to diversify and strengthen the teacher workforce must provide high-quality learning experiences that support the success and retention of Black, Indigenous, and people of color (BIPOC) teacher candidates and bilingual teacher candidates. Such work requires a holistic and systematic approach to conceptualizing instruction and mentoring that is both linguistically and culturally sustaining. To guide this work in the Master of Arts in Teaching in Clinically Based Elementary program at Oregon State University’s College of Education, we conducted a review of relevant literature and frameworks related to linguistically responsive and/or sustaining teaching or mentoring practices. We developed a set of ten mentoring competencies for school-based cooperating/clinical teachers and university supervisors. They are grouped into the domains of: Facilitating Linguistically and Culturally Sustaining Instruction, Engaging with Mentees, Recognizing and Interrupting Inequitable Practices and Policies, and Advocating for Equity. We also developed a set of twelve instructional competencies for teacher candidates as well as the university instructors who teach them. The instructional competencies are grouped into the domains of: Engaging in Self-reflection and Taking Action, Learning About Students and Re-visioning Instruction, Creating Community, and Facilitating Language and Literacy Development in Context. We are currently operationalizing these competencies to develop and conduct surveys and focus groups with various GYO stakeholders for the purposes of ongoing program evaluation and improvement, as well as further refinement of these competencies.

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