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Journal articles on the topic 'Gut-derived B cells'

Author: Grafiati

Published: 18 May 2024

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1

Wang, Juanjuan, Ningning Zhu, Xiaomin Su, Yunhuan Gao, and Rongcun Yang. "Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis." Cells 12, no. 5 (2023): 793. http://dx.doi.org/10.3390/cells12050793.

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The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the gastrointestinal tract. This commensal microbiota can contribute to the regulation of host immune response and homeostasis. Alterations of the gut microbiota have been found in many immune-related diseases. The metabolites generated by specific microorganisms in the gut microbiota, such as short-chain fatty acids (SCFAs), tryptophan (Trp) and bile acid (BA) metabolites, not only affect genetic and epigenetic regulation but also impact metabolism in the immune cells, including immunosuppressive and inflamma

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2

Su, Xiaomin, Yunhuan Gao, and Rongcun Yang. "Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis." Cells 11, no. 15 (2022): 2296. http://dx.doi.org/10.3390/cells11152296.

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Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such as indole-3-lactate (ILA), indole-3-acrylate (IAC), indole-3-propionate (IPA), indole-3-aldehyde (IAID), indoleacetic acid (IAA), indole-3-acetaldehyde and Kyn can be produced by intestinal microorganisms through direct Trp transformation and also, partly, the kynurenine (Kyn) pathway. These metabolites play a critical role in maintaining the homeostasis of the gut and systematic immunity and also potentially affe

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3

Daien, C., J. Tan, R. Audo, J. Mielle, and L. Macia. "OP0131 GUT DERIVED ACETATE PROMOTES REGULATORY B CELLS WITH ANTI-INFLAMMATORY EFFECTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 85.2–85. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4924.

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Background:Regulatory B cells (Bregs) are defective in many auto-immune diseases, i.e. rheumatoid arthritis (RA). The short-chain fatty acid (SCFA) acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes anti-inflammatory regulatory T cells and protects mice from type 1 diabetes and colitis. We hypothesized that acetate could be a good candidate to promote Bregs in auto-immune diseases.Objectives:To assess the effect of acetate on Breg number and function,in vitroandin vivoin mice and humans.Methods:Bregs were defined as IL-10 producing regulatory B cells (B10 cells)

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4

Zheng, Mingzhu, Kairui Mao, Difeng Fang, et al. "B cell residency but not T cell–independent IgA switching in the gut requires innate lymphoid cells." Proceedings of the National Academy of Sciences 118, no. 27 (2021): e2106754118. http://dx.doi.org/10.1073/pnas.2106754118.

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Immunoglobulin A (IgA)–producing plasma cells derived from conventional B cells in the gut play an important role in maintaining the homeostasis of gut flora. Both T cell–dependent and T cell–independent IgA class switching occurs in the lymphoid structures in the gut, whose formation depends on lymphoid tissue inducers (LTis), a subset of innate lymphoid cells (ILCs). However, our knowledge on the functions of non-LTi helper-like ILCs, the innate counter parts of CD4 T helper cells, in promoting IgA production is still limited. By cell adoptive transfer and utilizing a unique mouse strain, we

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Tsuda, Masato, Hiraku Okada, Natsuki Kojima, et al. "Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota." Journal of Immunology Research 2022 (May 4, 2022): 1–13. http://dx.doi.org/10.1155/2022/3974141.

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Gut-associated lymphoid tissue (GALT), such as Peyer’s patches (PPs), are key inductive sites that generate IgA+ B cells, mainly through germinal center (GC) responses. The generation of IgA+ B cells is promoted by the presence of gut microbiota and dietary antigens. However, the function of GALT in the large intestine, such as cecal patches (CePs) and colonic patches (CoPs), and their regulatory mechanisms remain largely unknown. In this study, we demonstrate that the CePs possess more IgG2b+ B cells and have fewer IgA+ B cells than those in PPs from BALB/c mice with normal gut microbiota. Ge

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Osman, Mohammad, Janice Russell та D. Neil Granger. "Lymphocyte-derived interferon-γ mediates ischemia-reperfusion-induced leukocyte and platelet adhesion in intestinal microcirculation". American Journal of Physiology-Gastrointestinal and Liver Physiology 296, № 3 (2009): G659—G663. http://dx.doi.org/10.1152/ajpgi.90495.2008.

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Although previous studies have implicated lymphocytes in the gut microvascular and inflammatory responses to ischemia-reperfusion (I/R), the lymphocyte population and lymphocyte-derived products that mediate these responses have not been defined. Platelet and leukocyte adhesion was measured in intestinal postcapillary venules of wild-type (WT) mice and mice genetically deficient in either CD4+ T cells (CD4−/−), CD8+ T cells (CD8−/−), B cells (B cell−/−), or interferon-γ (IFN-γ−/−) subjected to 45 min of ischemia and 4 h of reperfusion. The I/R-induced platelet and leukocyte recruitment respons

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Yaguchi, Junko, and Shunsuke Yaguchi. "Evolution of nitric oxide regulation of gut function." Proceedings of the National Academy of Sciences 116, no. 12 (2019): 5607–12. http://dx.doi.org/10.1073/pnas.1816973116.

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Although morphologies are diverse, the common pattern in bilaterians is for passage of food in the gut to be controlled by nerves and endodermally derived neuron-like cells. In vertebrates, nitric oxide (NO) derived from enteric nerves controls relaxation of the pyloric sphincter. Here, we show that in the larvae of sea urchins, there are endoderm-derived neuronal nitric oxide synthase (nNOS)-positive cells expressing pan-neural marker, Synaptotagmin-B (SynB), in sphincters and that NO regulates the relaxation of the pyloric sphincter. Our results indicate that NO-dependent pylorus regulation

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8

Sahputra, Rinal, Emma A. Murphy, Ruth Forman, et al. "Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse." Journal of Molecular Medicine 98, no. 9 (2020): 1301–17. http://dx.doi.org/10.1007/s00109-020-01954-3.

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Abstract The IgMi mouse has normal B cell development; its B cells express an IgM B cell receptor but cannot class switch or secrete antibody. Thus, the IgMi mouse offers a model system by which to dissect out antibody-dependent and antibody-independent B cell function. Here, we provide the first detailed characterisation of the IgMi mouse post-Trichuris muris (T. muris) infection, describing expulsion phenotype, cytokine production, gut pathology and changes in T regulatory cells, T follicular helper cells and germinal centre B cells, in addition to RNA sequencing (RNA seq) analyses of wild-t

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9

Kim, Chang H. "Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids." Cellular & Molecular Immunology 18, no. 5 (2021): 1161–71. http://dx.doi.org/10.1038/s41423-020-00625-0.

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AbstractA mounting body of evidence indicates that dietary fiber (DF) metabolites produced by commensal bacteria play essential roles in balancing the immune system. DF, considered nonessential nutrients in the past, is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory and allergic responses. Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are the major DF metabolites and mostly produced by specialized commensal bacteria that are capable of breaking down DF into simpler saccharides and further metabolizing the saccharid

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10

Weisel, Nadine M., Florian J. Weisel, Donna L. Farber, et al. "Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype." Blood 136, no. 24 (2020): 2774–85. http://dx.doi.org/10.1182/blood.2019002782.

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Abstract Although human B cells have been extensively studied, most reports have used peripheral blood as a source. Here, we used a unique tissue resource derived from healthy organ donors to deeply characterize human B-cell compartments across multiple tissues and donors. These datasets revealed that B cells in the blood are not in homeostasis with compartments in other tissues. We found striking donor-to-donor variability in the frequencies and isotype of CD27+ memory B cells (MBCs). A comprehensive antibody-based screen revealed markers of MBC and allowed identification of novel MBC subsets

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Cen, Selena, Nathalie Simard, and Christopher Paige. "B cell differentiation governed by distinct microenvironments (LYM7P.622)." Journal of Immunology 194, no. 1_Supplement (2015): 200.14. http://dx.doi.org/10.4049/jimmunol.194.supp.200.14.

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Abstract B cell differentiation is regulated by the surrounding microenvironment, which produces cytokines, chemokines, and adhesion molecules that guide B cell commitment and differentiation. The gastrointestinal tract, in constant interaction with microbiota, constitutes a distinctive microenvironment for B cell differentiation. While the bone marrow and spleen contain few IgA+ cells, the gut lamina propria is largely colonized by IgA+ cells, which contain a subset of myeloid-like plasma cells expressing IgA, TNFα, iNOS, CD11c, Ly6C and Ly6G. Whether the bone marrow stroma produces inhibitor

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Lanning, Dennis, and Katherine Knight. "Role of CXCL12 and its receptor, CXCR4, in diversification of the rabbit primary antibody repertoire (133.3)." Journal of Immunology 184, no. 1_Supplement (2010): 133.3. http://dx.doi.org/10.4049/jimmunol.184.supp.133.3.

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Abstract The antibody repertoire of early postnatal rabbits is of limited diversity due to preferential V gene usage during VDJ gene rearrangement. Early in life, rabbit B cells expand this repertoire by diversifying their VDJ genes in gut-associated lymphoid tissue. VDJ gene diversification begins around 1 week of age, in B cells located in the basolateral region of nascent follicles. Because these B cells share similarities with B cells in germinal center dark zones, we hypothesized that activated B cells localize to the basolateral region in response to the chemokine CXCL12. To test this hy

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Aihara, Fumiaki, Michael P. Breen, Feng Feng, Rachel Fearns, Joseph P. Mizgerd, and Thomas B. Kepler. "The Influence of The Lung Virome on Pulmonary B cells." Journal of Immunology 202, no. 1_Supplement (2019): 198.14. http://dx.doi.org/10.4049/jimmunol.202.supp.198.14.

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Abstract The human microbiome is a complex and diverse environment that is implicated in human health and disease. Major locations that host a microbiome include the gut, respiratory system, and the urogenital tracts. While there have been steady advances of the effect of our commensal flora in regions such as the gut microbiome, the impact of the pulmonary microbiome, specifically the viral arm of the microbiome (virome), remains unclear and under-researched. Recent studies have shown that pulmonary viruses can influence disease susceptibility to the benefit, or detriment, to the host. Despit

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Rocha, B., P. Vassalli, and D. Guy-Grand. "Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice." Journal of Experimental Medicine 180, no. 2 (1994): 681–86. http://dx.doi.org/10.1084/jem.180.2.681.

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We have investigated the origin of intraepithelial lymphocytes (IEL) populations in the murine gut, using reconstitution experiments in which the presence of thymus-derived cells of host or donor origin is rigorously controlled: RAG-/- mutant mice which have no T cells, were injected either with the bone marrow (BM) cells of nude mice or with selected peripheral lymph node (LN) T cells of euthymic mice. In thymectomized RAG-/- mice, injection of BM cells from nude mice led, after 2 mo, to the development of a peripheral B cell compartment and to the appearance, in the gut, of IEL bearing homod

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Davani, Dariush, Zeev Pancer, and Michael J. H. Ratcliffe. "Ligation of Surface Ig by Gut-Derived Antigen Positively Selects Chicken Bursal and Peripheral B Cells." Journal of Immunology 192, no. 7 (2014): 3218–27. http://dx.doi.org/10.4049/jimmunol.1302395.

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16

Wu, R., J. An, and C. Wang. "AB0072 THE METABOLITES WERE ALTERED IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1214.2–1215. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1763.

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BackgroundRheumatoid arthritis (RA) is characterized by persistent synovitis and abnormal antibodies production[1].The discovery of follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) has added a new understanding of the mechanisms of antibody production in RA such as anti-cyclic peptide containing citrulline (anti-CCP) [2]. The gut microbiota-derived metabolites are also important in regulating immune system to balance disease and health. And the altered gut microbiota-derived metabolites had been found in RA patients[3]. However, the relationship between gut microbiota-de

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Chen, Feidi, Ye Zhao, Xiangsheng Huang, et al. "GPR43 mediates microbiota metabolite SCFA induction of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3." Journal of Immunology 198, no. 1_Supplement (2017): 218.17. http://dx.doi.org/10.4049/jimmunol.198.supp.218.17.

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Abstract As a critical component in maintaining intestinal homeostasis, intestinal epithelial cells (IEC) are known to tune gut microbiota via antimicrobial peptides (AMP) production. In return, microbiota has been reported to regulate IEC expression of AMPs, including RegIIIg and certain defensins. The underlying mechanisms are, however, still not completely understood. The present study attempted to address the novel pathways by which gut microbiota regulates IEC expression of AMP as a way to contribute to intestinal homeostasis. We found that the mice with deficiency of GPR43, a receptor fo

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18

Jin, Linhua, Shinya Kimura, Yixin Zhou, et al. "The Anti-Proliferative Effects of Tricyclic Coumarin GUT-70 as An Hsp90 Inhibitor In Mantle Cell Lymphoma." Blood 116, no. 21 (2010): 3977. http://dx.doi.org/10.1182/blood.v116.21.3977.3977.

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Abstract Abstract 3977 Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma with poor prognosis, requiring novel anticancer strategies. Since p53 inactivating mutations occur primarily in the aggressive and refractory MCL variants, targeting p53-independent signaling pathways is of considerable interest. We previously reported the cytotoxic efficacy of a newly discovered tricyclic coumarin GUT-70 (5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2-butenyl) -10-propyl-2H,8H-benzo[1,2-b;3,4-b ]dipyran-8-one (C23H26O5) (synthesized at Nippon Shinyaku, Kyoto, Japan), originally derived from Calophy

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19

KAO, CHENG-YUAN, Cherng-Shyang Chang, Yi-Chu Liao, et al. "The Novel Roles of Dusp6 in Gut Barrier Modulation and Microbiome Shaping in a Mouse Colitis Model." Journal of Immunology 208, no. 1_Supplement (2022): 115.14. http://dx.doi.org/10.4049/jimmunol.208.supp.115.14.

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Abstract Gut microbiota dysbiosis and barrier integrity are important contributors to overall health and many diseases. Our study demonstrated that dual-specificity phosphatase 6 (Dusp6)-depletion is a novel modulator that enhances baseline gut barrier integrity. We found that Dusp6-knockout mice were more resistant to dextran sulfate sodium (DSS)-induced colitis and had enhanced intrinsic colonic tight-junctions and elongated microvilli before exposure to DSS. Our FMT in germ-free mice and co-housing experiments found that the Dusp6-knockout-derived gut microbiota contribute substantially to

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Wu, J. J., J. X. Chen, T. P. Rothman, and M. D. Gershon. "Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors." Development 126, no. 6 (1999): 1161–73. http://dx.doi.org/10.1242/dev.126.6.1161.

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The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR)were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only in the non-crest-derived population. The crest- and non-crest-derived cells were exposed in vitro to en

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Masenga, Sepiso K., Joreen P. Povia, Propheria C. Lwiindi, and Annet Kirabo. "Recent Advances in Microbiota-Associated Metabolites in Heart Failure." Biomedicines 11, no. 8 (2023): 2313. http://dx.doi.org/10.3390/biomedicines11082313.

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Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino a

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Jedrzkiewicz, Sean, Galina Kataeva, Cory M. Hogaboam, Steven L. Kunkel, Robert M. Strieter, and Derek M. McKay. "Superantigen Immune Stimulation Evokes Epithelial Monocyte Chemoattractant Protein 1 and RANTES Production." Infection and Immunity 67, no. 11 (1999): 6198–202. http://dx.doi.org/10.1128/iai.67.11.6198-6202.1999.

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ABSTRACT Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus aureus enterotoxin B (SEB; a model SAg)-activated immune cells. Also, MCP-1 and RANTES mRNAs were increased in jejunal enterocytes isolated from SEB-treated mice. We suggest that T-cell recruitment to the gut following SAg immune activation could be partially due to epithel

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Taham-zadeh, Dariush, Yuan Wu, and Michael Ratcliffe. "Role of antigen in later stages of B cell development (153.20)." Journal of Immunology 186, no. 1_Supplement (2011): 153.20. http://dx.doi.org/10.4049/jimmunol.186.supp.153.20.

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Abstract B cell development occurs in the gut associated lymphoid tissue (GALT) of many mammals and birds. In chickens, the early stages of B cell development, including colonization of bursal follicles, B cell proliferation within bursal follicles and repertoire diversification by gene conversion, are supported by surface Ig receptor related constructs that lack antigen binding capacity. Thus early B cell development requires Ig receptor expression but not sIg ligation. In contrast later stages of bursal development, including cortico-medullary redistribution of B cells and their maintenance

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Muku, Gulsum, Iain Murray, Juan Espín, and Gary Perdew. "Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist." Metabolites 8, no. 4 (2018): 86. http://dx.doi.org/10.3390/metabo8040086.

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Urolithins (e.g., UroA and B) are gut microbiota-derived metabolites of the natural polyphenol ellagic acid. Urolithins are associated with various health benefits, including attenuation of inflammatory signaling, anti-cancer effects and repression of lipid accumulation. The molecular mechanisms underlying the beneficial effects of urolithins remain unclear. We hypothesize that some of the human health benefits of urolithins are mediated through the aryl hydrocarbon receptor (AHR). Utilizing a cell-based reporter system, we tested urolithins for the capacity to modulate AHR activity. Cytochrom

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Simo, P., P. Simon-Assmann, C. Arnold, and M. Kedinger. "Mesenchyme-mediated effect of dexamethasone on laminin in cocultures of embryonic gut epithelial cells and mesenchyme-derived cells." Journal of Cell Science 101, no. 1 (1992): 161–71. http://dx.doi.org/10.1242/jcs.101.1.161.

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Previous studies have shown that glucocorticoids accelerate intestinal maturation and that this process is mediated by the mesenchymal cells. The possible involvement of laminin (LN), a basement membrane component, in this mesenchymal mediation has been analyzed. For this purpose, the influence of dexamethasone (DX) on the synthesis of LN, its chain composition and its cellular distribution has been examined biochemically and immunocytochemically in two different mesenchyme-derived cell populations, fetal intestinal mesenchymal cells and fetal skin fibroblasts, as well as in cocultures of inte

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Lambolez, Florence, Orly Azogui, Anne-Marie Joret, et al. "Characterization of T Cell Differentiation in the Murine Gut." Journal of Experimental Medicine 195, no. 4 (2002): 437–49. http://dx.doi.org/10.1084/jem.20010798.

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Gut intraepithelial CD8 T lymphocytes (T-IEL) are distinct from thymus-derived cells and are thought to derive locally from cryptopatch (CP) precursors. The intermediate stages of differentiation between CP and mature T-IEL were not identified, and the local differentiation process was not characterized. We identified and characterized six phenotypically distinct lineage-negative populations in the CP and the gut epithelium: (a) we determined the kinetics of their generation from bone marrow precursors; (b) we quantified CD3-ϵ, recombination activating gene (Rag)-1, and pre-Tα mRNAs expression

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Fernández-Tomé, Samuel, Alicia C. Marin, Lorena Ortega Moreno, et al. "Immunomodulatory Effect of Gut Microbiota-Derived Bioactive Peptides on Human Immune System from Healthy Controls and Patients with Inflammatory Bowel Disease." Nutrients 11, no. 11 (2019): 2605. http://dx.doi.org/10.3390/nu11112605.

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Bioactive peptides secreted by probiotic Bifidobacterium longum (peptide B7) and opportunistic pathogen Bacteroides fragilis (peptide B12) modulate the intestinal cytokine milieu in health. Here, we characterized their capacity to modulate both the mucosal cytokine production and the phenotype of circulating antigen presenting cells (APCs) in active inflammatory bowel disease (IBD). The IBD mucosa produced higher levels of pro-inflammatory cytokines referred to healthy controls (HCs). Peptides B7 and B12, however, did not ameliorate the mucosal cytokine milieu in IBD. Human circulating APCs (B

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Trent, Brandon J., Widian Jubair, Sabrina Fetchner, Meagan Chriswell, and Kristine Kuhn. "Promotion of Autoimmune Arthritis via Tryptophan Metabolism and Production of the Bacterial-Derived Tryptophan Metabolite Indole." Journal of Immunology 206, no. 1_Supplement (2021): 105.12. http://dx.doi.org/10.4049/jimmunol.206.supp.105.12.

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Abstract Dysbiosis of gut bacterial communities in autoimmunity is a noted phenomenon in both murine models and human patients; however, the mechanisms of dysbiosis that promote disease pathogenesis remain unclear. In agreement with such studies, our lab has published that administration of antibiotics to deplete the microbiota late in the course of murine collagen-induced arthritis (CIA) significantly ameliorated disease. To understand the mechanisms by which microbiota depletion would significantly decrease CIA, we analyzed cecal metabolites by LC-MS during CIA and after antibiotic treatment

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Bellezzo, J. M., R. S. Britton, B. R. Bacon, and E. S. Fox. "LPS-mediated NF-kappa beta activation in rat Kupffer cells can be induced independently of CD14." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 6 (1996): G956—G961. http://dx.doi.org/10.1152/ajpgi.1996.270.6.g956.

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Lipopolysaccharide (LPS) activation of macrophages occurs after LPS complexed with serum LPS-binding protein (LBP) binds CD14. Activation of the nuclear transcription factor NF-kappa B is directly related to this event. Since the role of CD14 in LPS signaling has not been evaluated in Kupffer cells, the resident hepatic macrophage, the purpose of this study was to characterize LPS-mediated NF-kappa B activation under CD14-dependent (1% serum, as a source of LBP) and CD14-independent (serum-free) conditions. Classic CD14-dependent signaling was seen in peritoneal macrophages where serum potenti

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Maybaum, T. A., and J. D. Reynolds. "B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain." Journal of Immunology 157, no. 4 (1996): 1474–84. http://dx.doi.org/10.4049/jimmunol.157.4.1474.

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Abstract To investigate the molecular events associated with B cell apoptosis, we analyzed follicular B cells from the large Peyer's patch (PP) in the sheep ileum. Over 95% of B cells generated in the ileal PP are rapidly destroyed by apoptosis. Ig V lambda sequences from apoptotic B cells were compared with sequence from B cells about to emigrate from the PP. The sequences originated from two germline genes, V lambda 5.1 and V lambda 5.3. Only V lambda 5.1 was rearranged in apoptotic cells, whereas both V lambda 5.1 and V lambda 5.3 were rearranged in B cells about to emigrate. Apoptotic B ce

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Tu, Zhengkun, Adel Bozorgzadeh, Robert H. Pierce, Jonathan Kurtis, I. Nicholas Crispe, and Mark S. Orloff. "TLR-dependent cross talk between human Kupffer cells and NK cells." Journal of Experimental Medicine 205, no. 1 (2008): 233–44. http://dx.doi.org/10.1084/jem.20072195.

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The liver protects the host from gut-derived pathogens yet is tolerant of antigenic challenge from food and commensal sources. Innate responses involving liver macrophages (Kupffer cells) and effector liver natural killer (NK) cells form the first line in this defense. We address the impact of Toll-like receptor (TLR) signaling on the cross talk between these two cells, and reveal how the liver displays a down-regulated inflammatory response to constitutive bacterial elements through the secretion of interleukin (IL) 10 yet retains a vigorous response to viral challenge. The data support the m

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Jin, Linhua, Shinya Kimura, Yixin Zhou, et al. "The Tricyclic Coumarin GUT-70 Induces Apoptosis and Cell Cycle Arrest Preferentially in Mantle Cell Lymphomas with Mutant p53." Blood 114, no. 22 (2009): 1684. http://dx.doi.org/10.1182/blood.v114.22.1684.1684.

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Abstract Abstract 1684 Poster Board I-710 Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma resistant to standard chemotherapy. Since p53 inactivating mutations occur primarily in the aggressive and refractory MCL variants, development of novel compounds that target p53-independent signaling pathways is of considerable interest. We investigated the cytotoxic efficacy and molecular mechanisms of a newly discovered anticancer agent GUT-70 (synthesized at Nippon Shinyaku, Kyoto, Japan), a natural product derived from the stem bark of Calophyllum brasiliense, characterized as a tricyclic

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Berkowska, Magdalena A., Gertjan J. A. Driessen, Vasilis Bikos, et al. "Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways." Blood 118, no. 8 (2011): 2150–58. http://dx.doi.org/10.1182/blood-2011-04-345579.

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Abstract Multiple distinct memory B-cell subsets have been identified in humans, but it remains unclear how their phenotypic diversity corresponds to the type of responses from which they originate. Especially, the contribution of germinal center-independent responses in humans remains controversial. We defined 6 memory B-cell subsets based on their antigen-experienced phenotype and differential expression of CD27 and IgH isotypes. Molecular characterization of their replication history, Ig somatic hypermutation, and class-switch profiles demonstrated their origin from 3 different pathways. CD

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Kapur, R. P., D. A. Sweetser, B. Doggett, J. R. Siebert, and R. D. Palmiter. "Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts." Development 121, no. 11 (1995): 3787–95. http://dx.doi.org/10.1242/dev.121.11.3787.

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Mice homozygous for the piebald lethal (sl) mutation, which have a complete deletion of endothelin receptor-B, fail to form ganglion cells in the distal large intestine and are nearly devoid of cutaneous melanocytes. These phenotypic features stem from incomplete colonization of the hindgut and skin by neural crest-derived neuroblasts and melanoblasts, respectively. We have used expression of a transgene, dopamine-beta-hydroxylase-nlacZ, to study colonization of the enteric nervous system in sl/sl embryos and sl/sl &lt;--&gt; wild-type chimeric mice. Enteric neuroblasts derived from th

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González-Sarrías, Antonio, Mar Larrosa, Francisco Abraham Tomás-Barberán, Piero Dolara та Juan Carlos Espín. "NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts". British Journal of Nutrition 104, № 4 (2010): 503–12. http://dx.doi.org/10.1017/s0007114510000826.

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Previous studies have reported the anti-inflammatory properties of pomegranate extracts, suggesting that ellagitannins (ET) and ellagic acid (EA) are the main anti-inflammatory compounds. However, both ET and EA are metabolised in vivo by the gut microbiota to yield urolithins (Uro) which can be found in the gut and in systemic bloodstream. The present study was carried out to evaluate the individual effect of EA and their microbiota-derived metabolites Uro on colon fibroblasts upon IL-1β treatment as an in vitro inflammation model. Uro-A and Uro-B (10 μm) inhibited PGE2 production (85 and 40

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Vinderola, Gabriel, Gabriela Perdigón, Jairo Duarte, Edward Farnworth, and Chantal Matar. "Effects of the oral administration of the products derived from milk fermentation by kefir microflora on immune stimulation." Journal of Dairy Research 73, no. 4 (2006): 472–79. http://dx.doi.org/10.1017/s002202990600197x.

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Nutritional status has a major impact on the immune system. Probiotic effects ascribed to fermented dairy products arise not only from whole microorganisms but also from metabolites (peptides, exopolysaccharides) produced during the fermentation. We recently demonstrated the immunomodulating capacity of kefir in a murine model. We now aimed at studying the immunomodulating capacity in vivo of the products derived from milk fermentation by kefir microflora (PMFKM) on the gut. BALB/c mice received the PMFKM for 2, 5 or 7 consecutive days. IgA+ and IgG+ cells were determined on histological slice

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Rahal, Zahraa, Fuduan Peng, Yuejiang Liu, et al. "Abstract 2883: Gut microbiome dysbiosis promotes immune suppression and lung cancer development." Cancer Research 83, no. 7_Supplement (2023): 2883. http://dx.doi.org/10.1158/1538-7445.am2023-2883.

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Abstract Mounting evidence supports synergistic roles for the gut microbiome in cancer progression. Yet, the interplay between the gut microbiome and immune responses in cancer is still poorly understood. We recently showed that gut microbiome changes are closely associated with development of Kras-mutant lung adenocarcinoma (KM-LUAD) in a human-relevant, tobacco-associated mouse model (Gprc5a-/-; G). Knockout of the antimicrobial protein Lcn2 in these mice (Gprc5a-/-/Lcn2-/-; GL) further reduced microbial diversity while enhancing inflammation and tumor development. We thus hypothesized that

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Wang, Haiguang, Fanta Barrow, Kira Florczak, et al. "T Follicular Helper Cells Restrain Obesity-Related Metabolic Disease by Damping Intestinal Inflammation." Journal of Immunology 210, no. 1_Supplement (2023): 64.01. http://dx.doi.org/10.4049/jimmunol.210.supp.64.01.

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Abstract The intestinal immune system is a central modulator of obesity-associated metabolic disease. Particularly, high-affinity intestinal IgA maintains gut homeostasis after its generation in a germinal center (GC) response that requires functional T follicular helper (Tfh) cells in Peyer’s patches (PP). The objective of this study was to determine how obesity affects Tfh function leading to metabolic disease. We investigated the phenotype of Tfh cells in diet-induced obese mice. Obese mice showed enlarged PP featured by an expansion of CXCR5 highICOS highTfh cells. Surprisingly, intestinal

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Krämer, S., A. Schimpl, and T. Hünig. "Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene." Journal of Experimental Medicine 182, no. 6 (1995): 1769–76. http://dx.doi.org/10.1084/jem.182.6.1769.

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Interleukin (IL) 2-deficient mice develop a fatal immunopathology characterized by lymphoadenopathy, splenomegaly, T cell infiltration of the bone marrow, loss of B cells, anemia, and inflammation of the gut. The thymus dependence of these disease symptoms was tested by introducing the IL-2 mutation into athymic mice. With the exception of an increase in CD8+ intrahepatic alpha/beta T cells, IL-2 deficiency had no detectable effect on leukocyte composition or health of athymic mice, indicating a key role for thymus-derived T cells in the initiation of disease and demonstrating that B cell deve

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Bhattarai, Chacchu, Phanindra Prasad Poudel, Arnab Ghosh, and Sneha Guruprasad Kalthur. "The <i>RET</i> gene encodes RET protein, which triggers intracellular signaling pathways for enteric neurogenesis, and <i>RET</i> mutation results in Hirschsprung's disease." AIMS Neuroscience 9, no. 1 (2022): 128–49. http://dx.doi.org/10.3934/neuroscience.2022008.

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<abstract> <p>Enteric neurons and ganglia are derived from vagal and sacral neural crest cells, which undergo migration from the neural tube to the gut wall. In the gut wall, they first undergo rostrocaudal migration followed by migration from the superficial to deep layers. After migration, they proliferate and differentiate into the enteric plexus. Expression of the Rearranged During Transfection (<italic>RET</italic>) gene and its protein RET plays a crucial role in the formation of enteric neurons. This review describes the molecular mechanism by which the <itali

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Riccardi, Carol, та David W. Pascual. "Head and Neck Lymph Node (HNLN) B Cells from L-Selectin−/− (L-Sel−/−) Mice Show αE Expression Independent of Cholera Toxin (CT) Exposure (41.9)". Journal of Immunology 178, № 1_Supplement (2007): S31. http://dx.doi.org/10.4049/jimmunol.178.supp.41.9.

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Abstract Oral immunization with soluble protein plus adjuvant stimulates excellent regional, but not distal Ab responses. Although low level expression of distal immune B cells is observed, these wane with time. Studies examining homing receptor expression should provide insight into understanding how distal mucosal immunity is maintained. Studies showed that B lymphocyte trafficking in the HNLN and NALT is L-Sel-dependent. However, the absence of L-Sel enhanced distal B cell maintenance following oral CT immunization of L-Sel−/− mice and was partly compensated by increased αEβ7+ B cells, as e

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Iwata, N., T. Murayama, Y. Matsumori, et al. "Autocrine loop through cholecystokinin-B/gastrin receptors involved in growth of human leukemia cells." Blood 88, no. 7 (1996): 2683–89. http://dx.doi.org/10.1182/blood.v88.7.2683.bloodjournal8872683.

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The cholecystokinin (CCK)-B/gastrin receptor binds two brain-gut hormones, CCK and gastrin, with high affinities. These peptides have a trophic effect on gastrointestinal cells expressing the receptor in vivo as well as in vitro. Recently, this receptor mRNA was reported to be expressed in immunocytes localized in the lamina propria of normal rat stomach mucosa. Here, we studied the receptor expression in human hematopoietic cells in order to determine whether they play a role in cell growth. The CCK-B/gastrin receptor mRNA was detectable in the polymorphonuclear (PMN) cells but not in the mon

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Bao, Bin, Youyuan Wang, Pavl Boudreau, et al. "BACTERIAL SPHINGOLIPIDS EXACERBATE COLITIS BY INHIBITING ILC3-DERIVED IL-22 PRODUCTION." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S63. http://dx.doi.org/10.1093/ibd/izae020.133.

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Abstract Commensal bacteria of the Bacteroidetes phylum are the primary producers of sphingolipids in the gut lumen. These lipids serve dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells (iNKT). Sphingolipid composition is significantly altered in fecal samples of patients with inflammatory bowel disease (IBD). However, the specific mechanisms by which bacterial sphingolipids modulate mucosal homeostasis and regulate intestinal inflammation remain unclear. In this study, we investigated t

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Hedges, Jodi F., Kerri M. Rask, and Mark A. Jutila. "Enhanced immunity following ingestion of plant derived polysaccharides (134.87)." Journal of Immunology 182, no. 1_Supplement (2009): 134.87. http://dx.doi.org/10.4049/jimmunol.182.supp.134.87.

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Abstract Considering the recent increased interest in dietary supplements by the public, characterization of their mechanisms and safety are warranted. Yamoa(tm), bark from the Funtumia elastica tree, has anecdotal positive effects in asthma patients. We have determined that polysaccharide components of Yamoa(tm) and other dietary supplements stimulate innate immunity similarly to LPS, in part by affecting γδ T cells. We hypothesized that orally administered Yamoa(tm) would effectively target this mucosal T cell subset and result in changes in peripheral and tissue-associated immune cells, and

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Abraham, Ninan, Daniel Patton, Adam Plumb, Stephen Redpath, Lisa Osborne та Georgia Perona-Wright. "The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling. (CCR1P.242)". Journal of Immunology 192, № 1_Supplement (2014): 48.2. http://dx.doi.org/10.4049/jimmunol.192.supp.48.2.

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Abstract IL-7 is a critical cytokine for lymphocyte development but its role in B cells is less well characterized. Using a knock-in mouse with a Tyr to Phe mutation at position 449 (IL-7Rα449F/449F mice) within the cytoplasmic domain of IL-7Rα, we evaluated the role of this YxxM motif in spleen B cells. IL-7Rα449F/449F mice had reduced numbers and increased death of follicular B cells compared to WT, but had significantly more follicular cells than IL-7Rα-/-. The death of IL-7Rα449F/449F follicular cells was not due to a failure to respond to BAFF or lower levels of BAFF. Marginal zone B cell

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Senizza, Alice, Maria Luisa Callegari, Biancamaria Senizza, et al. "Effects of Linoleic Acid on Gut-Derived Bifidobacterium breve DSM 20213: A Transcriptomic Approach." Microorganisms 7, no. 12 (2019): 710. http://dx.doi.org/10.3390/microorganisms7120710.

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Bacterial production of conjugated linoleic acid (CLA) has recently received great attention because of the potential health benefits of this fatty acid. Linoleic acid (LA) can be converted to CLA by several microorganisms, including bifidobacteria, possibly as a detoxification mechanism to avoid the growth inhibition effect of LA. In the present in vitro study, we investigated the gene expression landscape of the intestinal strain Bifidobacterium breve DSM 20213 when exposed to LA. Transcriptomic analysis using RNA-seq revealed that LA induced a multifactorial stress response in the test stra

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Boll, Erik Juncker, Bruno I. Cappellozza, and Giuseppe Copani. "PSIII-29 A Novel Direct-Fed Microbial Supports in Vitro Intestinal Integrity Under Inflamed Conditions." Journal of Animal Science 101, Supplement_3 (2023): 619–20. http://dx.doi.org/10.1093/jas/skad281.722.

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Abstract Ruminants are often exposed to pathogenic and non-pathogenic challenges during daily handling procedures and management activities. These responses, in turn, may trigger the release of pro-inflammatory compounds that can have negative effects on the host. Based on this rationale, we hypothesized that 1) pro-inflammatory cytokines (TNF-α and IFN-γ) would compromise the in vitro gut barrier integrity, and 2) a novel direct-fed microbial (DFM) formulation would support the gut barrier integrity under inflammatory conditions. Therefore, our objective was to evaluate the ability of a novel

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Mengge, Gao, Jun Kong, Yuqian Sun, et al. "G-CSF Induces MAIT Cells to Exert Anti-Intestinal Gvhd Effects Dependent on CXCR6 Mediated Chemotaxis." Blood 142, Supplement 1 (2023): 2048. http://dx.doi.org/10.1182/blood-2023-181445.

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Background: Graft-versus-host disease (GVHD) is a major complication leading to transplantation failure and affecting overall survival after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Granulocyte colony-stimulating factor (G-CSF) can induce T-cell tolerance and altering graft cell components to enhance GVHD prevention in HSCT. MAIT cells are a group of innate immune T cells. It has unique biological properties, including mucosal tissue enrichment, activation of microbial riboflavin derivatives and tissue repair properties, which determine MAIT cells play an important role

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Zhang, Hongwei, Sebastian Rausch, and Susanne Hartmann. "High resistance to intestinal nematode infection is associated with a strong bias for TFH cell responses, rapid IgG1 class switch and limited Th2 effector cell expansion." Journal of Immunology 206, no. 1_Supplement (2021): 99.20. http://dx.doi.org/10.4049/jimmunol.206.supp.99.20.

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Abstract Gastrointestinal nematode infections are highly prevalent in nature, lead to considerable morbidity in infected humans and cause high economical loss in animal husbandry. While it is clear that type 2 responses orchestrated by CD4+GATA-3+ Th2 cells are pivotal for the control of GI nematodes, the basis for differential susceptibility of distinct host genetic backgrounds is less well understood. The high resistance of ‘rapid responder’ SJL mice to infections with the small intestinal nematode H. polygyrus is evident in low parasite egg production and the termination of infection within

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Provitera, Livia, Andrea Tomaselli, Genny Raffaeli, et al. "Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner." Cells 12, no. 5 (2023): 760. http://dx.doi.org/10.3390/cells12050760.

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Necrotizing enterocolitis (NEC) is a devastating gut disease in preterm neonates. In NEC animal models, mesenchymal stromal cells (MSCs) administration has reduced the incidence and severity of NEC. We developed and characterized a novel mouse model of NEC to evaluate the effect of human bone marrow-derived MSCs (hBM-MSCs) in tissue regeneration and epithelial gut repair. NEC was induced in C57BL/6 mouse pups at postnatal days (PND) 3–6 by (A) gavage feeding term infant formula, (B) hypoxia/hypothermia, and (C) lipopolysaccharide. Intraperitoneal injections of PBS or two hBM-MSCs doses (0.5 ×

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