Journal articles on the topic 'Guo shi guan (China)'

Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2016 and May 2019. The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese (VC1 and VC2) and the European (VC3) validation cohorts collectively and independently. Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets. Results: The AUCs for TEPs in the combined validation cohort, VC1, VC2, and VC3 were 0.918 (95% CI 0.889-0.948), 0.923 (0.855-0.990), 0.918 (0.872-0.963), and 0.887 (0.813-0.960), respectively. Combination of TEPs and CA125 demonstrated an AUC of 0.922 (0.889-0.955) in the combined validation cohort; 0.955 (0.912-0.997) in VC1; 0.939 (0.901-0.977) in VC2; 0.917 (0.824-1.000) in VC3. For subgroup analysis, TEPs exhibited an AUC of 0.858, 0.859, and 0.920 to detect early-stage, borderline, non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis. Analysis of public datasets suggested that TEPs had potential to detect multiple malignancies (Table 1). Conclusions: TEPs had robustness, compatibility, and universality for preoperative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities, heterogeneous histological subtypes, early-stage ovarian cancer as well as other malignancies. However, these observations warrant prospective validations in a larger population before clinical utilities. Table 1. Performance for TEPs in public pan-cancer datasets. Disease n Healthy Control AUC, area under the curve (95% CI) Women NSCLC (non-small-cell lung cancer) 126 77 0.758 (0.691-0.825) Breast cancer 38 77 0.817 (0.726-0.909) Colorectal cancer 18 77 0.973 (0.945-1.000) Pancreatic cancer 16 77 0.993 (0.981-1.000) Glioblastoma 10 77 0.923 (0.831-1.000) Men NSCLC 119 82 0.746 (0.677-0.815) Colorectal cancer 25 82 0.933 (0.884-0.982) Pancreatic cancer 22 82 0.993 (0.984-1.000) Glioblastoma 19 82 0.981 (0.959-1.000) All NSCLC 245 159 0.774 (0.728-0.820) Colorectal cancer 40 159 0.978 (0.961-0.996) Breast cancer 38 159 0.821 (0.736-0.906) Pancreatic cancer 35 159 0.987 (0.974-0.999) Glioblastoma 35 159 0.931 (0.890-0.972) Hepatobiliary carcinomas 14 159 0.991 (0.978-1.000) Citation Format: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao. Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB168.

Abstract Objective: Benign breast disease (BBD), especially benign proliferative breast disease (BPBD), is related to increased breast cancer risk. However, few studies have examined whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD. The aim of this study was to evaluate the associations of lifestyle factors with risk of breast cancer among women biopsied for BBD within a multi-center, hospital-based, case-control study in China, in order to provide scientific basis of health guidance for BBD patients and lay the foundation for primary prevention of breast cancer. Methods: A multi-center, hospital-based, case-control study was conducted. Patients with BPBD (n=608) and patients with non-proliferative breast disease (NPBD) (n=366) were collected from 23 hospitals in 11 provinces during April 2012 to April 2013. A face-to-face survey, baseline data and fasting blood was collected with all study subjects. Serum adiponectin levels were assayed using ELISA. After 10 years, the cumulative incidence rate of breast cancer in the two groups was counted through follow-up. Logistic regression analysis was used to obtain the association between specific factors and risk of breast cancer. Results: After 10 years’ follow-up, 388 BPBD and 240 NPBD cases were included in the final analysis (Table 1), of which 16 (4.12%) and 3 (1.25%) developed breast cancer, respectively. The cumulative incidence of breast cancer between the two groups was significant difference (P=0.041). Compared with women in the NPBD group, BPBD group were more likely to be central obesity (with higher waist-to-hip ratio (WHR)) (OR 24.98, 95% CI 1.845-336.203, P=0.015) and less likely to have physical activity (OR 0.626, 95% CI 0.416-0.943, P=0.025) and less often to eat carrots (OR 0.616, 95% CI 0.398-0.953, P=0.030) (Table 2). Subgroup analyze indicated that, physical activity, eat carrots and ham sausage, body weight, BMI, waist circumference and WHR were statistical differences in premenopausal BPBD patients, while only physical activity (OR 0.423, 95% CI 0.269-0.665 P < 0.001) was the independent risk factors. Meanwhile, among the factors of Tea consumption, Glycemia, Body weight, BMI, Waist circumference, WHR and HMW/total adiponectin ratio in postmenopausal group, only HMW/total adiponectin ratio (OR 0.041, 95% CI 0.002-0.820 P=0.037) was statistically significant factor. These stratified multivariate logistic regression analysis results are shown in Table 3. Conclusion: In patients with BBD, physical activity may be the protect factor for breast cancer carcinogenesis in premenopausal women while lower HMW/total adiponectin ratio is a risk factor for postmenopausal women, which can provide direction for primary prevention of breast cancer. Table 1. Pathological types of all subjects. Table 2. The results of multivariate Logistic regression analysis. Table 3. Stratified multivariate Logistic regression analysis by menopause status. Citation Format: Chao Zheng, Dandan Ma, Linfeng Zhao, Maolin Guo, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shi-Guang Zhu, Wenshu Zuo, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Mingming Guo, Yongjiu Wang, Wenzhong Zhou, Shuya Huang, Zhaohui Li, Yajie Zhou, Lijuan Hou, Xinyi Yang, Xuan Zhang, Liyuan Liu, Zhigang Yu. Lifestyle factors are associated with breast cancer risk in women biopsied for benign breast diseases in China: 10-year results of a multi-center, hospital-based, case-control study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-03-31.

The Chinese species of Larnaca are reviewed. A new species, Larnaca (Larnaca) walle sp. nov. is described from China. Female of Larnaca (Larnaca) emarginata Bian, Guo & Shi, 2015 is described for the first time. The type specimen is deposited in Museum of Biology, East China Normal University.

In this paper, one new species of the genus Homogryllacris Liu, 2007, i.e. Homogryllacris obtusitubera sp. nov. and the previously unknown female of Homogryllacris brevispina Shi, Guo & Bian, 2012 are described from China. Meanwhile, the morphological photographs and habitus of these species are provided.

Based on the specimens of Homogryllacris deposited in the Guangxi Normal University, we describe two new species from Guangxi and Yunnan, China. Meanwhile, the morphological photographs and habitus of Homogryllacris brevispina Shi, Guo & Bian, 2012 and Homogryllacris gladiata Liu, 2007 are provided.

This paper deals with five species of the genus Homogryllacris Liu, 2007 from China, including one new species, i.e. Homogryllacris nigromacula sp. nov. Morphological illustrations of most species and habitus of the new species are provided. Moreover, one geographical population of Homogryllacris yunnana Shi, Guo & Bian, 2012 and intraspecific variation of Homogryllacris platycis Liu & Bian, 2021 are discussed and illustrated. All specimens examined are deposited in the Museum of Hebei University.

We record Trimeresurus yingjiangensis Chen, Zhang, Shi, Tang, Guo, Song et Ding, 2019 for the first time from Myanmar based on three specimens collected from Htamanthi wildlife sanctuary, Sagaing Division, Myanmar. Morphologically the newly collected specimens from Myanmar mostly agree with the type series of T. yingjiangensis. Phylogenetically these individuals were placed in a clade with T. yingjiangensis from China, the pairwise genetic distances in DNA sequences of the mitochondrial cytb gene and the nuclear gene fragment c-mos gene between these individuals and T. yingjiangensis from China are 1.34% and 0.06%, respectively. Our finding records T. yingjiangensis for the first time from outside of China.

Walker (1869) proposed the genus Larnaca with type species Larnaca fasciata Walker, 1869. Karny (1937) gave the characters of the genus and listed 8 species. Gorochov (2003) subdivided the genus into two subgenera: Larnaca and Paralarnaca, and their type species are Larnaca (Larnaca) fasciata Walker, 1869 (Malesia) and Larnaca (Paralarnaca) johni (Griffini, 1911) (Malesia) respectively, and described 2 new species, i.e. Larnaca (Larnaca) vietnamensis Gorochov, 2003 (type locality: Vietnam) and Larnaca (Larnaca) phetchaburi Gorochov, 2003 (type locality: Thailand). Bian et al. (2015) firstly reported Larnaca Walker, 1869 from China, and described 1 new species, i.e. Larnaca (Larnaca) emarginata Bian, Guo & Shi, 2015. So far, the genus Larnaca includes 13 species.

This article will briefly describe the features, methods, goals of family education in ancient China, as well as the relevant educational roles of the father and mother in the family. The article will also analyze one of the most unique characteristics of ancient Chinese family education: in each family fixed a tablet with the words 天地君亲 Tian Di Jun Qin Shi (Heaven, land, rulers, ancestors, sages). In ancient China, people believed that teachers and relatives, and heaven, earth, and monarchs, were objects that people should respect and worship. Obviously, this clearly differs from the traditions of most other countries. The idea of Tian Di Jun Qin Shi first appeared in Guo Yu (国语), and in Xunzi (荀子) you can see the initial form of this thought. Over the next 2000 years, these five words penetrate deeply into people's minds, and people often mention them in their daily lives. Their importance and value in Chinese culture and Chinese life are very important and indispensable. The role played by the idea of Tian Di Jun Qin Shi in ancient Chinese family education is more effective than any classical legal practice.

The study of Chinese logic started as the second wave of Western traditional logic spread through China. Following Sun Yirang’s initial work and Liu Shipei’s development of it, this field was preliminarily established by Hu Shi, Zhang Shizhao and Guo Zhanbo. Since the 1980s, it became commonplace to systematize Chinese logic based on the Western system of logic. Since the 1990s, though, the Chinese academic community has begun to reflect on this research method, which has led to the trend of reverting to Chinese culture and its own logic.

The article focuses on the need to consider classical medieval texts not only as sources of historical information, but also as author's works subject to a certain methodology and using a variety of historiographical technologies and ideological schemes. The specific subject of the study is the two main sources on the history of the Eastern and Western Khitans (“Khitan Guo Chi” / “History of the Khitan state” and “Liao Shi” / “History of the [dynasty] Liao”), who created the largest state structures in the pre-Mongol period. “Khian Guo Zhi” is more of a history of the Khitan ethnos, whereas “Liao Shi” is a history of the dynasty, i.e., of the state construction. As a result, we have the maximum possible penetration in those days into the two most important topics-the people as a geopolitical actor and the state as a civilizational-state structure. Their authors carried out impressive synthetic work to prove certain postulates. These are, strictly speaking, not scientific approaches, but ideological, existing, moreover, often in the form of Philistine fabrications. These sources raise a particularly significant problem of the origin of the Khitan, their dynasty, civilizational affiliation of the Khitan, the Khitan determination of the place in a nomadic world, the specifics of socio-economic and social system of the state of Liao, Khitan influence on the social development of the far East and East Asian regions. In them, the Chinese civilizational paradigm was applied to the fullest extent possible, the essential worldview settings of classical Chinese historiography are traced: Sino-centrism, sedentary centrism, Han-fan dichotomies and culture – nature. As a result, these works had a significant impact on the development of the two most common approaches to studying the history of Khitan, which are considered as classical barbarians who constantly attacked China and for this purpose created their own quasi-state, but under the influence of Chinese civilization “grew” to the level of the traditional dynasty.

Guo, G., Guo, X., Wang, Y., Zhang, X., Zhang, S., Li, X., Liu, L., Shi, W., Usman, T., Wang, X., Du, L. and Zhang, Q. 2014. Estimation of genetic parameters of fertility traits in Chinese Holstein cattle. Can. J. Anim. Sci. 94: 281–285. The objective of this study was to estimate genetic parameters for fertility traits in Chinese Holstein heifers and cows. Data of 20169 animals with 42106 records over a period of 10 yr (2001–2010) were collected from Sanyuan Lvhe Dairy Cattle Center in Beijing, China. Traits included age at first service (AFS), number of services (NS), days from calving to first service (CTFS), days open (DO), and calving interval (CI). Genetic parameters were estimated with multiple-trait animal model using the DMU software. Heritability estimates for AFS, NS, CTFS, DO and CI were 0.100±0.012, 0.040±0.017, 0.034±0.011, 0.053±0.019 and 0.056±0.014, respectively. Genetic correlations between traits observed ranged from −0.13 to 0.99. Genetic correlations between AFS with NS, CTFS, DO and CI were −0.31, 0.15, −0.13 and −0.15, respectively. Calving interval was strongly correlated with NS, CTFS and DO (0.49–0.99), and DO showed strong correlation with NS and CTFS (0.49 and 0.58, respectively). The genetic correlation between CTFS and NS was negative moderate (−0.25). Results were in range with previous literature estimates and can be used in Chinese Holstein genetic evaluation for fertility traits.

Brown marmorated stink bug (BMSB) is a polyphagous pest originating from Asia but is now established in North America, Europe and recently South America. It has not established in New Zealand but is considered a signi cant biosecurity threat. Surprisingly, there is very little accessible information on its potential impact on kiwifruit, one of New Zealand’s most important horticulture crops. Articles in Chinese characters1,2,3 published in Chinese journals more than a decade ago demonstrate that BMSB is an important kiwifruit pest in China and, therefore, of concern to New Zealand’s kiwifruit industry. However, these articles were unknown to the broader BMSB research community until recently. This example reemphasises the importance of searching Chinese databases with Chinese characters, along with standard searches in international databases, to ensure a comprehensive understanding of biosecurity risks to New Zealand. Zhang F, Chen Z, Zhang S. 2000. The occurrence and control of Halyomorpha halys in kiwifruit orchards. Northwest Horticulture 2: 38. Guo X, Shi X. 2003. The biology and integrated management of important kiwifruit pests. China Fruits 1: 45-46. Feng H. 2007. The occurrence and control of pests in kiwifruit orchards. Northwest Horticulture 12: 22.

This article is devoted to the analysis of actions undertaken by Wu Ze-tian 武則天 (624–705), the first and only woman in Chinese history, who was bequeathed the title of august emperor and founded the Great Zhou state (Da Zhou 大周； 690–705) to raise the status of the Wu 武 family, as they were represented in the main sources of study for this period – the normative histories Old Book of Tang and New Book of Tang. Career advancement steps of the three most well-known relatives (Wu Cheng-si 武承嗣 (649–698), Wu San-si 武三思 (?–707) and Wu You-ning 武攸宁 (? –705) are examined. Special attention is given to the main stages in the rise of the Empress’s ancestors, including her father Wu Shi-huo, who made the posthumous journey from a guo-gong 國公 to August Emperor (huang-di 皇帝). A conclusion is reached that Wu’s consistent actions in this direction allowed her to replace the royal Tang dynasty with the Wu family in the ideological structure of China for an entire decade. Nevertheless, in the final period of her reign, Wu Ze-tian was forced to give up the hope of installing the Wu family as rulers of China.

Abstract Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. Design Genomic profiling of GC patients including a Singapore cohort (>200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A-mutated GCs were analyzed to examine tumor microenvironmental changes arising from ARID1A loss. Genome-wide ARID1A binding and chromatin profiles (H3K27ac, H3K4me3, H3K4me1, ATAC-seq) of gastric cell lines were generated to identify gastric-specific epigenetic landscapes regulated by ARID1A. Distinct cancer hallmarks of ARID1A-mutated GCs were converged at the genomic, single-cell, and epigenomic level, and targeted by pharmacological inhibition. Results We observed prevalent ARID1A inactivation across GC molecular subtypes, with distinct mutational signatures and linked to a NFKB-driven pro-inflammatory tumour microenvironment. ARID1A-depletion caused loss of H3K27ac activation signals at ARID1A-occupied distal enhancers, but unexpectedly gain of H3K27ac at ARID1A-occupied promoters in genes such as NFKB1 and NFKB2. Promoter activation in ARID1A-mutated GCs was associated with enhanced gene expression, increased BRD4 binding, and reduced HDAC1 and CTCF occupancy. Combined targeting of promoter activation and tumour inflammation via bromodomain and NFKB inhibitors confirmed therapeutic synergy specific to ARID1A-genomic status. Conclusion Our results suggest a therapeutic strategy for ARID1A-mutated GCs targeting both tumour-intrinsic (BRD4-assocatiated promoter activation) and extrinsic (NFKB immunomodulation) cancer phenotypes. Citation Format: Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M. Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A. Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A. Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan, Singapore Gastric Cancer Consortium. Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P28.

<p><strong>Abstract.</strong> Both epoch-making high accuracy map of Japan named 日本分野図, Nihon bunya zu “Allocation Map of Japan” (Dr. Kazutaka Unno called it as “Astronomical Map of Japan”)compiled by Japanese Cartographer 森幸安 Kouan Mori in 1754,and following, 改正日本輿地路程全図”Kaisei Nihon Yochi Rotei Zenzu “Revised General Route Map of Japan” by 長久保赤水 Sekisui Nagakubo in1779 were created according to the latitude data observed in 14 provinces in Japan recorded in 天文瓊統 Tenmon Keitou (book of Astronomy and divination in Japan) written by Japanese astronomer 渋川春海 Harumi Shibukawa. And in 天文瓊統 Tenmon Keitou (book of Astronomy and divination in Japan) the latitude of 北京 Beijing, 南京 Nanjing and 高麗 Korea recorded in 四海験測 Si hăi yān tsē Nationwide survey conducted by 郭守敬 Guo Shoujin et al in1279 in 元 Yuan Dynasty were displayed for revision of calendar to new 授時暦 Shoushi-li calendar. 渋川春海 Harumi Shibukawa adopted 授時暦 Shoushi-li calendar formulated by 郭 守敬 Guo Shoujin et al to his 貞享改暦 Joukyou revision of calendar in Japan 1685. This proves that the technology of observation of the latitude in Japan was transmitted from China for revision of calendar and observed latitude datas recorded in Tenmon Keitou were exploited to the cartography of Map of Japan without land survey project.</p><p>In 1754 森幸安 Kouan Mori compiled his 日本分野図, Nihon bunya zu “Allocation Map of Japan” by Chinese technology of 方格図 fānggētu grid map east and west equidistant from the distance of latitude 1° by Chinese Cartographer 羅洪先 Luo Hong xian’s 廣輿図 Guan YuTu, “Vast map of China” in Ming. Kouan Mori improved his map of Japan to realise the particularity in each allocation grid. Kouan Mori learned global atlas from duplicate the Matteo Ricchhi’s 坤輿万国全圖 Kunyu Wanguo Quatu:general map of Myriad countries on the earth 1602. In 1779, 長久保赤水 Sekisui Nagakubo made many modifications to the Kouan Mori’s maps and improve it to carry in pocket, named 改正日本輿地路程全図 Kaisei Nihon Yochi Rotei Zenzu “Revised General Route Map of Japan” and published it. Since 1809, this Nagakubo’s map has been repeatedly duplicated and translated into the language of each country in Europe and published, in Russia in 1809 and 1810, in France in 1827 by name of famous Surveyor Krusenstern. In 1855&amp;ndash;1862 by United Kingdom Admiralty published the map “Japan Nipon (mean Honshuu Island) Kiusiu and Sikok and a part of coast of Korea” based on a replica map by Krusenstern in 1827. However, these were published without knowing the name of the Japanese original author Sekisui Nagakubo.</p>

Abstract Background: Gastric cancer (GC) ranks the fifth most common cancer and the fourth most frequent cause of cancer-related deaths. Genomically stable gastric cancers (GSGCs) represent 20% of all GCs and GSGC patients have the worst prognosis among all GC subtypes. Although two HER2-targeted antibody-drug conjugates (ADCs), RC48 and DS8201, have shown promising clinical efficacies, most GSGC patients do not benefit from these ADCs due to the infrequent and heterogeneous HER2 expression. Therefore, there remains a significant and unmet medical need for developing novel ADCs targeting GSGC tumors. Methods: In this presented study, a quantitative and unbiased approach was first used to identify potential targets for GSGC in a panel of human GSGC cell lines in reference with two normal human gastric epithelial cells. Cell membrane localizations of potential targets on GSGC cell lines were determined by immunofluorescent (IF) staining. To correlate it with clinically-relevant GSGC tumor samples, immunohistochemical (IHC) staining of potential targets were performed in human diffuse GC tumor tissues along with normal gastric tissues. Next, GSGC cellular internalization capability of antibodies against potential targets was evaluated. Then, an optimized target was selected for developing GSGC-targeted ADCs. A series of ADC formulations with different linkers and payloads were constructed and characterized. Their anti-tumor activities against GSGC cell lines were subsequently screened in order to identify the optimized ADC formulation. Eventually, the anti-tumor activity and biosafety profile of the optimized ADC formulation were determined in suppressing tumor growth, progression and metastasis by using established orthotopic and peritoneal metastasis models of GSGC. Results: We first identified CD54 as a potential molecular target for human GSGCs using comparative flow cytometric analysis. We next evaluated its potential as an ADC target for GSGC-targeted therapy by determining its overexpression levels, cell membrane localizations, and cell internalization activity in GSGC cells. Furthermore, we constructed and characterized a panel of CD54-targeted ADCs and identified an optimized ADC formulation by quantitatively determining their half maximum inhibitory concentrations (IC50s) and validated its anti-tumor efficacy against GSGC tumors. Meanwhile, there was no evidence to indicate histopathological damages to normal organs in the optimized ADC treated group. Conclusions: In this study, we identified a molecular target for GSGC using an unbiased and quantitative screening assay and explored its potential application in developing GSGC-targeted ADCs. In order to maximize its efficacy, we optimized the ADC formulations against GSGC cells using different ADC linkers and payloads. Our study provides a promising targeted therapeutic candidate for the clinical treatment of GSGC. Citation Format: Rui Xu, Li Yuan, Xiao-Qing Guan, Shi-Li Yao, Bing Zhu, Tong Yang, Chun Liu, Peng Guo, Jiang-Jiang Qin, Xiang-Dong Cheng. Rationally developing antibody drug conjugates targeting genomically stable gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5293.

Coromandel lacquer screen is a Chinese folding screen made from the 17th century to 19th century in China. The screen is usually about 250cm high, 600cm width and consisting of twelve panels. Although these screens were made in China during the Qing dynasty, they received their name from India’s Coromandel coast, where they were transshipped to Europe in the late 17th and early 18th centuries by merchants of the English and Dutch East India companies. The Dutch traders carried these screens from Bantam in Java, and in early accounts they were frequently called Bantam screens as well as Coromandel screens. This paper examines Coromandel lacquer screen's art historical significance in the incising global interaction and consumer culture in the 17th and 18th centuries. It first discusses historical and cultural background of production in China which have been little known about. The primary sources focus on the record of <i>Xiu Shi lu</i>, the 16th century book about lacquer, and the inscriptions left on the screens. They will give information about when the screens were produced, what was the purpose of them, and the technique of decoratively incising lacquer and adding polychrome to the voids, called <i>kuan cai</i> in Chinese. The lacquer screen features a continuous scene run through all twelve panels, just like a hand-scroll painting with variety of colours. The prominent subjects for decoration are human figures, landscape and bird-and-flower. The narrative theme with human figures, such as Birthday Reception for General Guo Ziyi and the World of Immortals were shaped by literature or play. Also, the parallels between the lacquer screens and the paintings on the same theme are found. The scenes with Europeans are rare but bring various interpretations within the historical context of the time. The landscape themes, such as the Scenes of Lake Xihu and the Nine Bend in Mountain Wuyi, were depicted famous scenic spots in China. The composition and expression of the screens were probably inspired by landscape woodblock prints, it’s because the technique of lacquer screen and woodblock cutting are similar. Lastly, bird-and-flower theme has a long tradition of wishing longevity, happiness and peace in one’s life and produced in various medium. Thanks to the enormous progress in navigation and discovered sea roots in the 16th century, Dutch and England East India Companies imported quantities of Chinese lacquerworks in the 17th century. As Chinoiserie gain popularity all over Europe, Chinese objects were consumed in various ways. Imported Coromandel lacquer screens were incorporated into European interiors. They were cut into a number of panels, which mounted within wood paneling on walls and inserted into contemporary furniture. The lacquer screen also inspired European’s imitation of Asian lacquer known by a variety of names. This paper surveys Coromandel lacquer screen’s domestic production, exploding consumption and global conquest from the 17th century to 18th centuries, when the screen was explosively made. The lacquer screen is an active participant in cross-cultural interaction, not merely a passive commodity of china. Investigating the material culture of the lacquer screen, it was originally created in chinese domestic background concerned with social prestige, in Europe, consumed to show off exotic luxury and triggered a new stylistic changes in chinoiserie.

Abstract The association of programmed cell death-ligand 1 (PD-L1) expression with the activity of immune checkpoint inhibitor therapy setting has encouraged us to study the prevalence of PD-L1 in muscle invasive urothelial bladder cancer (MIUBC) patients. Since, the prevalence of PD-L1 expression and its prognostic role in MIUBC is unclear in China, we conducted a multi-center, prospective, epidemiological study to investigate prevalence of high PD-L1 expression and its correlation with other exploratory biomarkers including CD8+ T cells and tumor mutation burden (TMB) in Chinese MIUBC patients (NCT03433924). The study enrolled newly diagnosed, untreated MIUBC patients from 17 hospitals in China. High PD-L1 expression by Ventana PD-L1 [SP263] assay was defined as 1) ≥25% tumor cell (TC) + or 2) tumor associated immune cell (IC) area &gt;1%: ≥25% IC+; 3) IC area=1%: 100% IC+. The primary outcome was prevalence of high PD-L1 expression; secondary outcome was PD-L1 expression profile in TC or IC in patients. An exploratory study was conducted to investigate the percentage of patients with high infiltration of CD8+ T cells and elevated TMB using immunohistochemistry and next generation sequencing, respectively. High CD8+ and TMB status was considered if it refers to ˃ median value (3%) and ˃10 mut/Mb, respectively. Association of PD-L1 expression with demographic and baseline characteristics was evaluated by logistic regression model while PD-L1 with tumor biomarkers were evaluated by spearman’s rank correlation coefficient. Overall, 248 MIUBC patients were enrolled and 229 patients with PD-L1 data were included. High PD-L1 expression was observed in 52.4% patients. High PD-L1 expression was positive in 59 (25.8%) patients of TC and 82 (35.8%) patients of IC. CD8+ T cell and TMB showed high expression in 44.5% and 54.1% patients, respectively, with mean TMB of 14.14 mut/Mb. The exploratory analysis showed no significant association of PD-L1 expression with age, gender, primary tumor site, metastatic disease, regional lymph node, tobacco use or AJCC stage. Further a weak and positive correlation was observed between percentage of TC with membrane PD-L1 positivity and CD8+ T cells (0.34, 95%Cl, 0.22 - 0.45, p˂0.001), IC with membrane PD-L1 positivity and CD8+ T cells (0.44, 95%Cl, 0.33 - 0.54, p˂0.001), TC with membrane PD-L1 positivity and TMB (0.05, 95%Cl, -0.08 - 0.19, p=0.441), IC with membrane PD-L1 positivity and TMB (0.16, 95%Cl, 0.02 - 0.29, p=0.020). In conclusion, our study showed high prevalence of PD-L1 expression in patients with MIUBC along with their weak, positive correlation with CD8+ T cells and TMB. These findings are consistent with other studies that show that PD-L1 and TMB stand as the most robust predictive biomarkers, but may be uncorrelated. With subsequent follow-up time, the effect of biomarkers on survival will be assessed in future study. Citation Format: Yu Fan, Tao Dai, Dahong Zhang, Hongqian Guo, Fangjian Zhou, Benkang Shi, Shaogang Wang, Zhigang Ji, Chunxi Wang, Xudong Yao, Qiang Wei, Nanhui Chen, Jinchun Xing, Jinjian Yang, Chuize Kong, Jian Huang, Dingwei Ye, Liqun Zhou. Prevalence of PD-L1 expression and its correlation with tumor biomarkers in the Chinese muscle invasive urothelial bladder carcinoma patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6658.

Introdução: A COVID-19 tornou-se uma emergência de saúde pública no ano de 2020, sendo caracterizada como pandemia no mês de março. Os idosos compõem o grupo de risco dessa doença. Objetivo: Avaliar os efeitos da pandemia de COVID-19 sobre os idosos. Material e Método: A busca pelos artigos foi realizada através da plataforma Pubmed, com a inclusão de 17 estudos. Resultados: Os resultados ressaltaram a prevalência da doença entre a população idosa, e evidenciaram que esse grupo apresenta sintomas atípicos e com duração ligeiramente mais longa desde o início da sintomatologia até a sua admissão, tornando-se mais difícil a identificação da infecção de forma precoce. As manifestações clínicas mais relatadas foram: febre, tosse, produção de escarro, diarreia, fadiga, pneumonia e lesão cardíaca aguda. Também se observa que comorbidades, como hipertensão e doença pulmonar obstrutiva crônica, levam a uma disfunção cardíaca e pulmonar devido a mudanças fisiológicas e anatômicas dos pulmões, agravando o quadro clínico dos pacientes. Os exames de imagem se mostraram grandes aliados ao diagnóstico das alterações pulmonares decorrentes da infecção, além da realização do exame RT-PCR. Conclusão: Os idosos compõem o grupo de risco da COVID-19, sendo indivíduos com comorbidades os mais susceptíveis à agravamentos clínicos. Há necessidades em seguir as recomendações da OMS por não haver um tratamento específico destinado a essa patologia. Descritores: Infecções por Coronavírus; Idoso; Diagnóstico Clínico. Referências World Health Organization [homepage internet]. Pandemia de doença por coronavirus (COVID-19) [acesso em 19 nov 2020]. 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Abstract Background Osteosarcoma (OS) is a highly aggressive malignant tumor of mesenchymal origin and prone to early hematogenous metastases. The 5-year overall survival of metastatic OS is only approximately 20% to 30%. Therefore, it is still clinical dilemma in the treatment of OS. Thus,understanding the molecular features of metastatic osteosarcoma become increasingly important. Methods Formalin-fixed, paraffin-embedded or fresh tissues and matched blood samples were collected from OS patients for whole exome sequencing using next-generation sequencing at OrigiMed (Shanghai, China), a College of American Pathologists accredited and Clinical Laboratory Improvement Amendments certified laboratory. Genomic alterations including single nucleotide variations (SNVs), short and long insertions/deletions (INDELs), copy number variations (CNVs), and gene rearrangements were assessed. Tumor mutational burden (TMB) and the number of tumor neoantigens (NEO) were also measured. Results In total, 38 patients including 29 males and 9 females were recruited with a median age of 19.5 years. Among them, 12 patients had first metastases to bone (group B). The metastatic sites included femur, fibula, pelvis, ribs, sacrum, and spine. The median age of group B was 19.5 years. Twenty-six (26) patients had first metastases to lung (group L). The median age of group L was 14 years.The most frequently mutated genes in OS was TP53 (55.3%), followed by MYC (36.8%), MUC16 (26.3%), PTK2 (21.1%), RAD21 (21.1%), and CDK4 (18.4%). However, genetic features between Groups B and Group L patients were different. In group B patients, the median percentage of SNVs and short INDELs was 94.7% of the overall mutations, and the median percentage of CNVs was 4.3%. In contrast, the median percentage of SNVs and short INDELs in group L was 58.8%, and the median percentage of CNVs was 36.7%. The mutations patterns were clearly different between Group B and Group L with a predominant SNV & INDEL in Group B and a mixture feature of SNV & INDEL and CNV in Group L. Inaddition the median TMB in group B was significantly higher than that in group L (4.85 muts/Mb vs 2.4 muts/Mb, P&lt;0.05). Also, the median number of tumor NEO in group B was nearly 6 times higher than that in group L (743 vs 128.5, P=0.0016). Conclusion Our study identified different molecular features of patients with OS firstly metastasizing to lung and to bone. OS with first bone metastases had a predominant SNV and short INDEL, high TMB level, and high NEO counts, while OS with first lung metastasis had an increased CNV, low TMB, and low NEO counts. Our results suggest that metastatic OS that firstly spread to bone and to lung may be two distinct subgroups and may adopt different treatment strategies. Citation Format: Lu Xie, Zhenyu Cai, Xiaodong Tang, Wei Guo, Fanfei Meng, Xin Zhang, Xiaoliang Shi, Fei Pang. Distinct genetic features between osteosarcomas firstly metastasizing to bone and to lung [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5669.

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Abstract Background: Metronomic chemotherapy, defined as frequent administration of. chemotherapeutic agents at a non-toxic dose without extended rest periods, can overcome drug resistance and achieve disease control with reduced toxicity compared to conventional chemotherapy in maximum tolerated dose by shifting the therapeutic target from tumor cells to tumor endothelial cells. Some of the previous studies of oral vinorelbine have shown good data in efficacy and safety in advanced breast cancer. Methods: The multicenter, open-label, non-inferiority, randomized phase 2 study (NCT03854617) aimed to evaluate the efficacy and safety of oral metronomic vinorelbine in 13 hospitals in China. Eligible HER2-negative breast cancer patients previously treated with anthracycline or taxane regimens were randomized (1:1) to receive metronomic dosage of oral vinorelbine (50mg/3 times a week) or conventional dosage of oral vinorelbine (60mg/m2 weekly for cycle 1 and 80mg/m2 weekly for subsequent cycles in the absence of grade 3 or 4 toxicity) for first-line/second-line chemotherapy. The primary end point was Disease Control Rate (DCR) and a non-inferiority margin of 6% was defined for DCR. Patient characteristics, progression-free survival (PFS), overall survival (OS) and safety/adverse events (AEs) were among the parameters assessed. The expression of 27 cytokines was profiled longitudinally in these patients at baseline and at regular intervals during therapy. Results: Between February 2019 and September 2020, a total of 171 patients were enrolled and randomized to metronomic dosage group (86 patients) and conventional dosage group (85 patients). 136 patients were hormone receptor(HR)positive and 117 patients (68.4%) had visceral metastases. The DCR was 59.3% (95% CI:48.17% to 69.78%) in the metronomic dosage group and 67.1% (95% CI:56.02% to 76.87%) in the conventional dosage group. Whereas, the 18-month survival rate was higher in the metronomic dosage group than that in the conventional dosage group (68.7% vs 43.0%).The median progression-free survival in the metronomic dosage group was 2.8 months (95% CI:1.40 to 3.50) compared with 4.1 months (95% CI:2.80 to 6.20) in the conventional dosage group. Grade 3 or higher adverse events were significantly less frequent in patients in the metronomic dosage group than patients in the conventional dosage group (19.8% vs 48.2%, P&lt;0.001). By comparing the variation of cytokine profiles at baseline and after 6-week treatment in 122 patients, multilevel partial least squares discriminant analysis (PLS-DA) suggested the variation of VEGF, MIP-1α, IL-1B, IL-17, MCP-1, IL-13, PDGF-BB, IL-4 and RANTES were significantly different between the metronomic dosage group and the conventional dosage group during the treatment (all VIP values &gt; 1.2). As for the patients in the metronomic dosage group, GM-CSF, MCP-1, TNF-α, IL-10, IL-13 and MIP-1α were potential biomarkers between the response patients and non-response patients (all VIP values &gt; 1.2). Conclusions: Oral metronomic vinorelbine decreased the risk of severe toxicity significantly and may be an option for older patients and for those intolerable to standard chemotherapy with proper predictive biomarkers, though this study couldn’t prove to show the non-inferiority of oral metronomic vinorelbine for first-line or second-line chemotherapy previously treated with anthracycline or taxane in HER2-negative metastatic breast cancer. Citation Format: Fei Ma, Xinlan Liu, Yanxia Shi, Xiuwen Guan, Huihui Li, Xiaojia Wang, Yuee Teng, Qiang Liu, Jin Yang, Man Li, Qingyuan Zhang, Weihong Zhao, Caiwen Du, Lili Sheng, Binghe Xu. A randomized phase II study investigating oral metronomic vinorelbine versus conventional dosage of vinorelbine in HER2-negative metastatic breast cancer previously treated with anthracycline or taxane:clinical results and biomarker analysis [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-16-02.

Simulasi desain implan sendi pinggul bertujuan untuk menganalisis total deformasi maksimum, tegangan prinsipal maksimum, dan tegangan geser maksimum dengan kombinasi variasi waktu, gerakan, dan pembebanan. Simulasi memungkinkan suatu objek diujicobakan secara visual sebelum diproduksi sebagai purwarupa. Fungsi dari simulasi adalah untuk meminimalisir terjadinya kegagalan dan untuk memangkas biaya produksi. Sebelum memulai simulasi suatu objek perlu dibuatkan desain. Desain dalam penelitian ini menggunakan software CAD yakni Inventor 2014, sedangkan analisis metode elemen hingga dalam desain implan memanfaatkan simulasi ANSYS 18.1. Analisis metode elemen hingga didasarkan pada aktivitas berjalan, melompat, dan menuruni tangga selama kurun waktu 0 detik hingga 4,5 detik. Hasil simulasi menunjukkan bahwa desain implan sendi pinggul menghasilkan 4079 nodal, 2157 Elemen, dan total deformasi maksimum sebesar 0,097 mm (berjalan), 0,2 mm (melompat), dan 0,11 mm (menuruni tangga). Tegangan prinsipal maksimum adalah 32 MPa (berjalan), 66,96 MPa (melompat), dan 73,93 MPa (menuruni tangga). Tegangan geser maksimum adalah 19,74 MPa (berjalan), 41,28 MPa (melompat), dan 45,58 MPa (menuruni tangga).Kata kunci: simulasi; implan sendi pinggul; metode elemen hingga; Mg Alloy.The simulation of the hip joint implant design aims to analyze maximum total deformation, maximum principal stress, and maximum shear stress with a combination of variations in time, motion and loading. Simulation allows an object to be tested visually before being produced as a prototype. Function of simulation is to minimize the occurrence of failures and to cut production costs. Before starting to simulate an object a design needs to be made. The design in this study used CAD software, namely Inventor 2014, while the finite element method analysis in implant design used ANSYS 18.1 simulation. Finite element method analysis is based on walking, jumping and descending stairs over a period of 0 seconds to 4.5 seconds. Simulation results show that hip joint implant design produces 4079 nodals, 2157 elements, and a maximum total deformation of 0.097 mm (walking), 0.2 mm (jumping), and 0.11 mm (descending stairs). Maximum principal stresses are 32 MPa (walking), 66.96 MPa (jumping), and 73.93 MPa (descending stairs). Maximum shear stresses are 19.74 MPa (walking), 41.28 MPa (jumping), and 45.58 MPa (descending stairs).Keywords : Simulation; Hip Joint Implants; Finite Element Method; Mg AlloyDAFTAR RUJUKANAhmed, A., Hameed, P., Shaikh, F., Hussain, Z., Hussain, N., & Aslam, M. (2017). Simulation tools application for arti fi cial lighting in buildings. Renewable and Sustainable Energy Reviews, August, 0–1. https://doi.org/10.1016/j.rser.2017.10.035Boyd, D. D. (2016). General aviation accidents related to exceedance of airplane weight/center of gravity limits. 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This paper presents some results of rainfall forecast in the monsoon onset period in South Vietnam, with the use of ensemble Kalman filter to assimilate observation data into the initial field of the model. The study of rainfall forecasts are experimented at the time of Southern monsoon outbreaks for 3 years (2005, 2008 and 2009), corresponding to 18 cases. In each case, there are five trials, including satellite wind data assimilation, upper-air sounding data assimilation, mixed data (satellite wind+upper-air sounding data) assimilation and two controlled trials (one single predictive test and one multi-physical ensemble prediction), which is equivalent to 85 forecasts for one trial. Based on the statistical evaluation of 36 samples (18 meteorological stations and 18 trials), the results show that Kalman filter assimilates satellite wind data to forecast well rainfall at 48 hours and 72 hours ranges. With 24 hour forecasting period, upper-air sounding data assimilation and mixed data assimilation experiments predicted better rainfall than non-assimilation tests. The results of the assessment based on the phase prediction indicators also show that the ensemble Kalman filter assimilating satellite wind data and mixed data sets improve the rain forecasting capability of the model at 48 hours and 72 hour ranges, while the upper-air sounding data assimilation test produces satisfactory results at the 72 hour forecast range, and the multi-physical ensemble test predicted good rainfall at 24 hour and 48 hour forecasts. The results of this research initially lead to a new research approach, Kalman Filter Application that assimilates the existing observation data into input data of the model that can improve the quality of rainfall forecast in Southern Vietnam and overall country in general.References Bui Minh Tuan, Nguyen Minh Truong, 2013. 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The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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Aim: systematic review of studies in the medical literature of children with COVID – 19 in order to provide evidence of clinical, paraclinical characteristics and relative risk factors of severe degree in children with COVID-19. Research subjects: A systematic review of studies on COVID-19 in children published in the international medical literature. Research methods: the information of research reports was selected from information posted on the COVID-19 update reporting portal of the Ministry of Health, PubMed, EMBASE, Cochrane Library, WHO COVID-19 Database, China National Knowledge Infrastructure (CNKI) Database, WanFang Database through system overview. Results: we collected 115 studies related to COVID-19 in children, published from January 2020 to August 2021, and by screening, we selected 21 studies related to clinical, paraclinical characteristics and relative risk factors of severe degree in children with COVID-19. 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As the largest and most comprehensive Chinese database in the world, China National Knowledge Infrastructure (CNKI: Zhong guo zhi shi ji chu she shi gong cheng 中国知识基础设施工程, also commonly known as Zhi wang 知网)1 is supervised by Tsinghua University and Tonfang Knowledge Network (TKN), a high-tech enterprise funded by Tsinghua University in 1997. It is supported by the Chinese Ministry of Education, the Publicity Department of the Communist Party of China, the Ministry of Science and Technology, the State Administration of the Press, Publication, Radio, Film and Television of the People's Republic of China and the State Planning Commission of the PRC. In December 1996, CNKI began providing CD-ROM and CAJ-CD for Chinese academic journals, and it was officially launched in 1999. This repository initially focused on Chinese academic journals and later expanded its coverage to PhD dissertations, masters’ theses, conference proceedings, yearbooks, books and patent documents. It is divided into three categories: ‘databases’, ‘specialized sources’, and ‘international sources’, including ProQuest and Taylor and Francis journal databases. Ten service centres are established across the world, including Beijing, North America, Japan, Korea, Taiwan and Hong Kong; users include universities, research institutions, government think tanks, industries, hospitals and public libraries.2 CNKI (or CIKRD) updates its information on a daily basis, and its current growth rate is approximately 350,000 new journal articles per month.

The curtain rose. The howling of desert wind filled the performance hall in the Shanghai Grand Theatre. Into the center stage, where a scenic construction of a mountain cliff and a desert landscape was dimly lit, entered the character of the Daoist priest Wang Yuanlu (1849–1931), performed by Chen Yizong. Dressed in a worn and dusty outfit of dark blue cotton, characteristic of Daoist priests, Wang began to sweep the floor. After a few moments, he discovered a hidden chambre sealed inside one of the rock sanctuaries carved into the cliff.Signaled by the quick, crystalline, stirring wave of sound from the chimes, a melodious Chinese ocarina solo joined in slowly from the background. Astonished by thousands of Buddhist sūtra scrolls, wall paintings, and sculptures he had just accidentally discovered in the caves, Priest Wang set his broom aside and began to examine these treasures. Dawn had not yet arrived, and the desert sky was pitch-black. Priest Wang held his oil lamp high, strode rhythmically in excitement, sat crossed-legged in a meditative pose, and unfolded a scroll. The sound of the ocarina became fuller and richer and the texture of the music more complex, as several other instruments joined in.Below is the opening scene of the award-winning, theatrical dance-drama Dunhuang, My Dreamland, created by China’s state-sponsored Lanzhou Song and Dance Theatre in 2000. Figure 1a: Poster Side A of Dunhuang, My Dreamland Figure 1b: Poster Side B of Dunhuang, My DreamlandThe scene locates the dance-drama in the rock sanctuaries that today are known as the Dunhuang Mogao Caves, housing Buddhist art accumulated over a period of a thousand years, one of the best well-known UNESCO heritages on the Silk Road. Historically a frontier metropolis, Dunhuang was a strategic site along the Silk Road in northwestern China, a crossroads of trade, and a locus for religious, cultural, and intellectual influences since the Han dynasty (206 B.C.E.–220 C.E.). Travellers, especially Buddhist monks from India and central Asia, passing through Dunhuang on their way to Chang’an (present day Xi’an), China’s ancient capital, would stop to meditate in the Mogao Caves and consult manuscripts in the monastery's library. At the same time, Chinese pilgrims would travel by foot from China through central Asia to Pakistan, India, Nepal, Bangladesh, and Sri Lanka, playing a key role in the exchanges between ancient China and the outside world. Travellers from China would stop to acquire provisions at Dunhuang before crossing the Gobi Desert to continue on their long journey abroad. Figure 2: Dunhuang Mogao CavesThis article approaches the idea of “abroad” by examining the present-day imagination of journeys along the Silk Road—specifically, staged performances of the various Silk Road journey-themed dance-dramas sponsored by the Chinese state for enhancing its cultural and foreign policies since the 1970s (Kuang).As ethnomusicologists have demonstrated, musicians, choreographers, and playwrights often utilise historical materials in their performances to construct connections between the past and the present (Bohlman; Herzfeld; Lam; Rees; Shelemay; Tuohy; Wade; Yung: Rawski; Watson). The ancient Silk Road, which linked the Mediterranean coast with central China and beyond, via oasis towns such as Samarkand, has long been associated with the concept of “journeying abroad.” Journeys to distant, foreign lands and encounters of unknown, mysterious cultures along the Silk Road have been documented in historical records, such as A Record of Buddhist Kingdoms (Faxian) and The Great Tang Records on the Western Regions (Xuanzang), and illustrated in classical literature, such as The Travels of Marco Polo (Polo) and the 16th century Chinese novel Journey to the West (Wu). These journeys—coming and going from multiple directions and to different destinations—have inspired contemporary staged performance for audiences around the globe.Home and Abroad: Dunhuang and the Silk RoadDunhuang, My Dreamland (2000), the contemporary dance-drama, staged the journey of a young pilgrim painter travelling from Chang’an to a land of the unfamiliar and beyond borders, in search for the arts that have inspired him. Figure 3: A scene from Dunhuang, My Dreamland showing the young pilgrim painter in the Gobi Desert on the ancient Silk RoadFar from his home, he ended his journey in Dunhuang, historically considered the northwestern periphery of China, well beyond Yangguan and Yumenguan, the bordering passes that separate China and foreign lands. Later scenes in Dunhuang, My Dreamland, portrayed through multiethnic music and dances, the dynamic interactions among merchants, cultural and religious envoys, warriors, and politicians that were making their own journey from abroad to China. The theatrical dance-drama presents a historically inspired, re-imagined vision of both “home” and “abroad” to its audiences as they watch the young painter travel along the Silk Road, across the Gobi Desert, arriving at his own ideal, artistic “homeland”, the Dunhuang Mogao Caves. Since his journey is ultimately a spiritual one, the conceptualisation of travelling “abroad” could also be perceived as “a journey home.”Staged more than four hundred times since it premiered in Beijing in April 2000, Dunhuang, My Dreamland is one of the top ten titles in China’s National Stage Project and one of the most successful theatrical dance-dramas ever produced in China. With revenue of more than thirty million renminbi (RMB), it ranks as the most profitable theatrical dance-drama ever produced in China, with a preproduction cost of six million RMB. The production team receives financial support from China’s Ministry of Culture for its “distinctive ethnic features,” and its “aim to promote traditional Chinese culture,” according to Xu Rong, an official in the Cultural Industry Department of the Ministry. Labeled an outstanding dance-drama of the Chinese nation, it aims to present domestic and international audiences with a vision of China as a historically multifaceted and cosmopolitan nation that has been in close contact with the outside world through the ancient Silk Road. Its production company has been on tour in selected cities throughout China and in countries abroad, including Austria, Spain, and France, literarily making the young pilgrim painter’s “journey along the Silk Road” a new journey abroad, off stage and in reality.Dunhuang, My Dreamland was not the first, nor is it the last, staged performances that portrays the Chinese re-imagination of “journeying abroad” along the ancient Silk Road. It was created as one of many versions of Dunhuang bihua yuewu, a genre of music, dance, and dramatic performances created in the early twentieth century and based primarily on artifacts excavated from the Mogao Caves (Kuang). “The Mogao Caves are the greatest repository of early Chinese art,” states Mimi Gates, who works to increase public awareness of the UNESCO site and raise funds toward its conservation. “Located on the Chinese end of the Silk Road, it also is the place where many cultures of the world intersected with one another, so you have Greek and Roman, Persian and Middle Eastern, Indian and Chinese cultures, all interacting. Given the nature of our world today, it is all very relevant” (Pollack). As an expressive art form, this genre has been thriving since the late 1970s contributing to the global imagination of China’s “Silk Road journeys abroad” long before Dunhuang, My Dreamland achieved its domestic and international fame. For instance, in 2004, The Thousand-Handed and Thousand-Eyed Avalokiteśvara—one of the most representative (and well-known) Dunhuang bihua yuewu programs—was staged as a part of the cultural program during the Paralympic Games in Athens, Greece. This performance, as well as other Dunhuang bihua yuewu dance programs was the perfect embodiment of a foreign religion that arrived in China from abroad and became Sinicized (Kuang). Figure 4: Mural from Dunhuang Mogao Cave No. 45A Brief History of Staging the Silk Road JourneysThe staging of the Silk Road journeys abroad began in the late 1970s. Historically, the Silk Road signifies a multiethnic, cosmopolitan frontier, which underwent incessant conflicts between Chinese sovereigns and nomadic peoples (as well as between other groups), but was strongly imbued with the customs and institutions of central China (Duan, Mair, Shi, Sima). In the twentieth century, when China was no longer an empire, but had become what the early 20th-century reformer Liang Qichao (1873–1929) called “a nation among nations,” the long history of the Silk Road and the colourful, legendary journeys abroad became instrumental in the formation of a modern Chinese nation of unified diversity rooted in an ancient cosmopolitan past. The staged Silk Road theme dance-dramas thus participate in this formation of the Chinese imagination of “nation” and “abroad,” as they aestheticise Chinese history and geography. History and geography—aspects commonly considered constituents of a nation as well as our conceptualisations of “abroad”—are “invariably aestheticized to a certain degree” (Bakhtin 208). Diverse historical and cultural elements from along the Silk Road come together in this performance genre, which can be considered the most representative of various possible stagings of the history and culture of the Silk Road journeys.In 1979, the Chinese state officials in Gansu Province commissioned the benchmark dance-drama Rain of Flowers along the Silk Road, a spectacular theatrical dance-drama praising the pure and noble friendship which existed between the peoples of China and other countries in the Tang dynasty (618-907 C.E.). While its plot also revolves around the Dunhuang Caves and the life of a painter, staged at one of the most critical turning points in modern Chinese history, the work as a whole aims to present the state’s intention of re-establishing diplomatic ties with the outside world after the Cultural Revolution. Unlike Dunhuang, My Dreamland, it presents a nation’s journey abroad and home. To accomplish this goal, Rain of Flowers along the Silk Road introduces the fictional character Yunus, a wealthy Persian merchant who provides the audiences a vision of the historical figure of Peroz III, the last Sassanian prince, who after the Arab conquest of Iran in 651 C.E., found refuge in China. By incorporating scenes of ethnic and folk dances, the drama then stages the journey of painter Zhang’s daughter Yingniang to Persia (present-day Iran) and later, Yunus’s journey abroad to the Tang dynasty imperial court as the Persian Empire’s envoy.Rain of Flowers along the Silk Road, since its debut at Beijing’s Great Hall of the People on the first of October 1979 and shortly after at the Theatre La Scala in Milan, has been staged in more than twenty countries and districts, including France, Italy, Japan, Thailand, Russia, Latvia, Hong Kong, Macao, Taiwan, and recently, in 2013, at the Lincoln Center for the Performing Arts in New York.“The Road”: Staging the Journey TodayWithin the contemporary context of global interdependencies, performing arts have been used as strategic devices for social mobilisation and as a means to represent and perform modern national histories and foreign policies (Davis, Rees, Tian, Tuohy, Wong, David Y. H. Wu). The Silk Road has been chosen as the basis for these state-sponsored, extravagantly produced, and internationally staged contemporary dance programs. In 2008, the welcoming ceremony and artistic presentation at the Olympic Games in Beijing featured twenty apsara dancers and a Dunhuang bihua yuewu dancer with long ribbons, whose body was suspended in mid-air on a rectangular LED extension held by hundreds of performers; on the giant LED screen was a depiction of the ancient Silk Road.In March 2013, Chinese president Xi Jinping introduced the initiatives “Silk Road Economic Belt” and “21st Century Maritime Silk Road” during his journeys abroad in Kazakhstan and Indonesia. These initiatives are now referred to as “One Belt, One Road.” The State Council lists in details the policies and implementation plans for this initiative on its official web page, www.gov.cn. In April 2013, the China Institute in New York launched a yearlong celebration, starting with "Dunhuang: Buddhist Art and the Gateway of the Silk Road" with a re-creation of one of the caves and a selection of artifacts from the site. In March 2015, the National Development and Reform Commission (NDRC), China’s top economic planning agency, released a new action plan outlining key details of the “One Belt, One Road” initiative. Xi Jinping has made the program a centrepiece of both his foreign and domestic economic policies. One of the central economic strategies is to promote cultural industry that could enhance trades along the Silk Road.Encouraged by the “One Belt, One Road” policies, in March 2016, The Silk Princess premiered in Xi’an and was staged at the National Centre for the Performing Arts in Beijing the following July. While Dunhuang, My Dreamland and Rain of Flowers along the Silk Road were inspired by the Buddhist art found in Dunhuang, The Silk Princess, based on a story about a princess bringing silk and silkworm-breeding skills to the western regions of China in the Tang Dynasty (618-907) has a different historical origin. The princess's story was portrayed in a woodblock from the Tang Dynasty discovered by Sir Marc Aurel Stein, a British archaeologist during his expedition to Xinjiang (now Xinjiang Uygur autonomous region) in the early 19th century, and in a temple mural discovered during a 2002 Chinese-Japanese expedition in the Dandanwulike region. Figure 5: Poster of The Silk PrincessIn January 2016, the Shannxi Provincial Song and Dance Troupe staged The Silk Road, a new theatrical dance-drama. Unlike Dunhuang, My Dreamland, the newly staged dance-drama “centers around the ‘road’ and the deepening relationship merchants and travellers developed with it as they traveled along its course,” said Director Yang Wei during an interview with the author. According to her, the show uses seven archetypes—a traveler, a guard, a messenger, and so on—to present the stories that took place along this historic route. Unbounded by specific space or time, each of these archetypes embodies the foreign-travel experience of a different group of individuals, in a manner that may well be related to the social actors of globalised culture and of transnationalism today. Figure 6: Poster of The Silk RoadConclusionAs seen in Rain of Flowers along the Silk Road and Dunhuang, My Dreamland, staging the processes of Silk Road journeys has become a way of connecting the Chinese imagination of “home” with the Chinese imagination of “abroad.” Staging a nation’s heritage abroad on contemporary stages invites a new imagination of homeland, borders, and transnationalism. Once aestheticised through staged performances, such as that of the Dunhuang bihua yuewu, the historical and topological landscape of Dunhuang becomes a performed narrative, embodying the national heritage.The staging of Silk Road journeys continues, and is being developed into various forms, from theatrical dance-drama to digital exhibitions such as the Smithsonian’s Pure Land: Inside the Mogao Grottes at Dunhuang (Stromberg) and the Getty’s Cave Temples of Dunhuang: Buddhist Art on China's Silk Road (Sivak and Hood). They are sociocultural phenomena that emerge through interactions and negotiations among multiple actors and institutions to envision and enact a Chinese imagination of “journeying abroad” from and to the country.ReferencesBakhtin, M.M. The Dialogic Imagination: Four Essays. Austin, Texas: University of Texas Press, 1982.Bohlman, Philip V. “World Music at the ‘End of History’.” Ethnomusicology 46 (2002): 1–32.Davis, Sara L.M. Song and Silence: Ethnic Revival on China’s Southwest Borders. New York: Columbia University Press, 2005.Duan, Wenjie. “The History of Conservation of Mogao Grottoes.” International Symposium on the Conservation and Restoration of Cultural Property: The Conservation of Dunhuang Mogao Grottoes and the Related Studies. Eds. Kuchitsu and Nobuaki. Tokyo: Tokyo National Research Institute of Cultural Properties, 1997. 1–8.Faxian. A Record of Buddhistic Kingdoms. Translated by James Legge. New York: Dover Publications, 1991.Herzfeld, Michael. Ours Once More: Folklore, Ideology, and the Making of Modern Greece. Austin: University of Texas Press, 1985.Kuang, Lanlan. Dunhuang bi hua yue wu: "Zhongguo jing guan" zai guo ji yu jing zhong de jian gou, chuan bo yu yi yi (Dunhuang Performing Arts: The Construction and Transmission of “China-scape” in the Global Context). Beijing: She hui ke xue wen xian chu ban she, 2016.Lam, Joseph S.C. State Sacrifice and Music in Ming China: Orthodoxy, Creativity and Expressiveness. New York: State University of New York Press, 1998.Mair, Victor. T’ang Transformation Texts: A Study of the Buddhist Contribution to the Rise of Vernacular Fiction and Drama in China. Cambridge, Mass.: Council on East Asian Studies, 1989.Pollack, Barbara. “China’s Desert Treasure.” ARTnews, December 2013. Sep. 2016 <http://www.artnews.com/2013/12/24/chinas-desert-treasure/>.Polo, Marco. The Travels of Marco Polo. Translated by Ronald Latham. Penguin Classics, 1958.Rees, Helen. Echoes of History: Naxi Music in Modern China. Oxford: Oxford University Press, 2000.Shelemay, Kay Kaufman. “‘Historical Ethnomusicology’: Reconstructing Falasha Liturgical History.” Ethnomusicology 24 (1980): 233–258.Shi, Weixiang. Dunhuang lishi yu mogaoku yishu yanjiu (Dunhuang History and Research on Mogao Grotto Art). Lanzhou: Gansu jiaoyu chubanshe, 2002.Sima, Guang 司马光 (1019–1086) et al., comps. Zizhi tongjian 资治通鉴 (Comprehensive Mirror for the Aid of Government). Beijing: Guji chubanshe, 1957.Sima, Qian 司马迁 (145-86? B.C.E.) et al., comps. Shiji: Dayuan liezhuan 史记: 大宛列传 (Record of the Grand Historian: The Collective Biographies of Dayuan). Beijing: Zhonghua shuju, 1959.Sivak, Alexandria and Amy Hood. “The Getty to Present: Cave Temples of Dunhuang: Buddhist Art on China’s Silk Road Organised in Collaboration with the Dunhuang Academy and the Dunhuang Foundation.” Getty Press Release. Sep. 2016 <http://news.getty.edu/press-materials/press-releases/cave-temples-dunhuang-buddhist-art-chinas-silk-road>.Stromberg, Joseph. “Video: Take a Virtual 3D Journey to Visit China's Caves of the Thousand Buddhas.” Smithsonian, December 2012. Sep. 2016 <http://www.smithsonianmag.com/smithsonian-institution/video-take-a-virtual-3d-journey-to-visit-chinas-caves-of-the-thousand-buddhas-150897910/?no-ist>.Tian, Qing. “Recent Trends in Buddhist Music Research in China.” British Journal of Ethnomusicology 3 (1994): 63–72.Tuohy, Sue M.C. “Imagining the Chinese Tradition: The Case of Hua’er Songs, Festivals, and Scholarship.” Ph.D. Dissertation. Indiana University, Bloomington, 1988.Wade, Bonnie C. Imaging Sound: An Ethnomusicological Study of Music, Art, and Culture in Mughal India. Chicago: University of Chicago Press, 1998.Wong, Isabel K.F. “From Reaction to Synthesis: Chinese Musicology in the Twentieth Century.” Comparative Musicology and Anthropology of Music: Essays on the History of Ethnomusicology. Eds. Bruno Nettl and Philip V. Bohlman. Chicago: University of Chicago Press, 1991. 37–55.Wu, Chengen. Journey to the West. Tranlsated by W.J.F. Jenner. Beijing: Foreign Languages Press, 2003.Wu, David Y.H. “Chinese National Dance and the Discourse of Nationalization in Chinese Anthropology.” The Making of Anthropology in East and Southeast Asia. Eds. Shinji Yamashita, Joseph Bosco, and J.S. Eades. New York: Berghahn, 2004. 198–207.Xuanzang. The Great Tang Dynasty Record of the Western Regions. Hamburg: Numata Center for Buddhist Translation & Research, 1997.Yung, Bell, Evelyn S. Rawski, and Rubie S. Watson, eds. Harmony and Counterpoint: Ritual Music in Chinese Context. Stanford: Stanford University Press, 1996.

Purpose This study aims to examine an important mechanism in the policy-led institutional transitions in China, namely, Te Shi Te Ban (Special Treatments for Special Matters) – an institutional device that facilitates policy implementation. The discussions are contextualized based on the latest chapter of China’s institutional transition, known as the reform initiative of Fang Guan Fu (i.e. the FGF reform: delegate power, streamline administration and optimize government services), which is a policy regime introduced in 2018 to improve the state-market relationship for better socioeconomic development. Design/methodology/approach Based on the theoretical lens of proto-institutions and institutional work and using real-life examples from mass media, this perspective paper examines the effects of the Special Treatments in the institutional transition under the FGF Reform. Findings The Special Treatments are the proto-institutions purposively adopted by the regulators in China to innovate, supervise and renovate the rules and norms during policy implementation. They produce both incremental and radical institutional effects which allow for a more efficient and effective policy-led institutional transition. Originality/value This study contributes to institutional theory in the Chinese management context. Foremost, this study introduces the concept of proto-institutional work and shows how proto-institutions can serve as a mechanism to support and manage the process of institutional transition. In addition, to the best of the authors’ knowledge, this paper is the first to study the FGF Reform – the latest reform initiative in China and theorize an under-researched but important mechanism in its institutional environment – the Special Treatments for Special Matters.

The cost-effectiveness of SGLT2i can be modulated by patients’ characteristics, such as cardiovascular risks. We performed an individualized cost-effectiveness assessment of SGLT2i when added to metformin in people with inadequately controlled T2D to quantify the modulating effect of patients’ characteristics on the cost-effectiveness of SGLT2i. We identified survey participants with T2D receiving metformin monotherapy who had an A1c level above 7.0% from the National Health and Nutrition Examination Survey (2013-2018) . We applied a simulation-based smoothing method to populate the survey sample to its represented national population. We used the BRAVO diabetes model to simulate the lifetime cost and QALYs associated with SGLT2i or sulfonylureas. Treatment escalations were governed by the A1c level at 7% and 8% consequentially. Both costs and QALYs were discounted at 3% annually, and the incremental cost-effectiveness ratio (ICER) threshold was set at $100,000/QALYs. The study sample included 2.89 million individuals. Compared with sulfonylureas, the use of SGLT2i was associated with an average of $9,400 higher medical cost and 0.10 additional QALY, leading to an ICER of $94,000/QALY in the overall population. SGLT2i was cost-effective in people with a history of heart failure (ICER: $67,000/QALY) and myocardial infarction (ICER: $94,000/QALY) , and marginally cost-effective in stroke patients (ICER: $100,000/QALY) . Among individuals without CVD, SGLT2i was cost-effective only in subgroups with HbA1c &gt; 7.5%, age &gt; 60, and diabetes duration &gt; 10 years. Overall, SGLT2i was only cost-effective in individuals with a baseline 10-year CVD risk over 16%, constituting 51.6% of the overall population. Our results align closely with the ADA guideline on the recommended population for SGLT2i use. Out-of-pocket payment subsidy or cost-sharing reduction of SGLT2i should be prioritized in patient subgroups in which SGLT2i has high economic values. Disclosure D. Guan: None. S. Niu: None. V. Fonseca: Consultant; Abbott, Asahi Kasei Corporation, Bayer AG, Novo Nordisk, Sanofi, Research Support; Fractyl Health, Inc., Jaguar Gene Therapy, Stock/Shareholder; Abbott, Amgen Inc., BRAVO4Health, Mellitus Health. L. Shi: None. N. Laiteerapong: None. J. Guo: None. H. Shao: Board Member; BRAVO4HEALTH, LLC.

Сучасне професійне середовище характеризується швидкими змінами та вимагає від працівників здатності до кар’єрної адаптивності, що стає ключовою компетенцією для успішної кар’єри та ефективної роботи в організаціях. Основною метою наукової розвідки було дослідження концепції кар’єрної адаптивності в контексті сучасної організаційної психології через аналіз її впливу на професійний розвиток й організаційні результати. Проведений аналіз теоретичних робіт та емпіричних досліджень, пов’язаних з кар’єрною адаптивністю дозволив розглянути існуючі інструменти оцінки та стратегії розвитку адаптивності. Вивчені та обмірковані результати лонгітюдних і перехресних досліджень сприяли виявленню зв’язку між кар’єрною адаптивністю та різними професійними й організаційними результатами. Встановлено існування суттєвого позитивного зв’язку між кар’єрною адаптивністю індивідів і широким спектром ключових показників їхньої професійної діяльності та загального благополуччя. Серед виявлених результатів особливе місце займає зростання задоволеності кар’єрою, підвищення рівня залученості до роботи, активізація процесів професійного розвитку, а також позитивний вплив на індивідуальне та організаційне благополуччя. Значною мірою досягнення цих позитивних результатів можливе завдяки застосуванню адаптивних поведінкових стратегій, що дозволяють особам ефективно реагувати на мінливі умови та виклики сучасного робочого середовища. На основі проведеного дослідження зроблено висновок, що кар’єрна адаптивність відіграє роль ключового фактора, який визначає успіх професійного розвитку особистості та ефективності організації в цілому. Підтримка та активний розвиток кар’єрної адаптивності мають стати пріоритетними напрямками в діяльності HR-спеціалістів, керівників організацій та розробників корпоративних програм з управління талантами. 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LANGUAGE NOTE | Document text in Chinese; abstract also in English. 《説文》籀文出自《史籀篇》，《史籀篇》的時代問题，向來頗有爭議。班固（32—92）、許慎（約58—約147）以《史籀篇》爲周宣王太史所作，歷代學者皆沿用其説，惟清末王國維别爲新説，以籀文爲戰國時西土秦國通行之文字。此後，學者紛紛重新審視籀文的時代，至今未有定論。值得注意的是，王國維以籀文爲戰國文字，乃基於其對籀文形體特點之觀察。本文針對王國維對籀文特點的看法作進一步探討，認爲王氏所描述的籀文特點大致不誤，惟他以此論定籀文爲戰國文字則難以成立。事實上，籀文的特點與西周晚期金文的風格十分相似，二者可視爲同類書體。原本《史籀篇》或取材於西周晚期之文字材料，並將字形稍加整齊化而寫成。《史籀篇》中的籀文，是太史籀在西周晚期衆多字體中確立的“正體”字。For more than two thousand years, “Zhou-wen” 籀文, as the form of character used in Shizhoupian 史籀篇, has been considered as a kind of script prevailing in the Western Zhou dynasty 西周. This viewpoint was initiated by Ban Gu 班固 (32-92 A.D) and Xu Shen 許慎 (58?-147? A.D) in the period of Eastern Han 東漢. However, in the late Qing period 晚清, by observing the style and characteristics of “Zhou-wen” presented in Shuowenjiezi 説文解字, Wang Guowei 王國維 argues that “Zhou-wen” may not belong to the period of Western Zhou, but rather is a form of character practiced in Qin 秦 of the Warring States period (475-221 B.C.). This argument leads to a point of controversy about the formulation of “Zhou-wen”. My study is an investigation of the style and characteristics of “Zhou-wen “. Comparing “Zhou-wen” with the inscriptions in Shang 商 and Zhou 周 dynasty, I conclude that the description of characteristics made by Wang Guo Wei was probably correct. Nevertheless, Wang’s judgment on the forming age of “Zhou-wen” is not precise. It is because the style and characteristics of “Zhou-wen” is similar to the inscriptions of the late Western Zhou period rather than those in the Warring State period. Hence, I believe in the traditional views initiated by Ban Gu 班固 and Xu Shen 許慎, that Shizhoupian 史籀篇 should be established in the late Western Zhou period by Tai Shi Zhou 太史籀. “Zhou-wen” should be the standardized form of character which practiced in China within that period.

In post-socialist China, gender norms are marked by rising divorce rates (Kleinman et al.), shifting attitudes towards sex (Farrer; Yan), and a growing commercialisation of sex (Zheng). These phenomena have been understood as indicative of market reforms unhinging past gender norms. In the socialist period, the radical politics of the time moulded women as gender neutral even as state policies emphasised their feminine roles in maintaining marital harmony and stability (Evans). These ideas around domesticity bear strong resemblance to pre-socialist understandings of womanhood and family that anchored Chinese society before the Communists took power in 1949. In this pre-socialist understanding, women were categorised into a hierarchy that defined their rights as wives, mothers, concubines, and servants (Ebrey and Watson; Wolf and Witke). Women who transgressed these categories were regarded as potentially dangerous and powerful enough to break up families and shake the foundations of Chinese society (Ahern). This paper explores the extent to which understandings of Chinese femininity have been reconfigured in the context of China’s post-1979 development, particularly after the 2000s.The popular television dramas Chinese Style Divorce (2004, Divorce), Dwelling Narrowness (2009, Dwelling), and Divorce Lawyers (2014, Lawyers) are set against this socio-cultural backdrop. The production of these shows is regulated by the China State Administration of Radio, Film, and Television (SARFT), who has the power to grant or deny production and distribution permits. Post-production, the dramas are sold to state-owned television stations for distribution (Yu 36). Haiqing Yu summarises succinctly the state of Chinese media: “Chinese state manipulation and interference in the media market has seen the party-state media marketized but not weakened, media control decentralized but not reduced, and the media industry commercialized but not privatized” (42). Shot in one of the biggest cities in Shandong, Qingdao, Divorce focuses on Doctor Song Jianping and his schoolteacher wife Lin Xiaofeng and the conflicts between Song and Lin, who quits her job to become a stay-at-home mom after her husband secures a high-paying job in a foreign-invested hospital. Lin becomes paranoid and volatile, convinced that their divorced neighbour Xiao Li is having an affair with Song. Refusing to explain the situation, Song is willing to give her a divorce but fights over guardianship of their son. In the end, it is unconfirmed whether they reconcile or divorce. Divorce was recognised as TV Drama of the Year in 2004 and the two leads also won awards for their acting. Reruns of the show continue to air. According to Hui Faye Xiao, “It is reported that many college students viewed this TV show as a textbook on married life in urban settings” (118). Dwelling examines the issue of skyrocketing housing prices and the fates of the Guo sisters, Haizao and Haiping, who moved from rural China to the competitive economically advanced metropolis. Haiping is obsessed with buying an apartment while her younger sister becomes the mistress of a corrupt official, Song Siming. Both sisters receive favours from Song, which leads to Haiping’s success in purchasing a home. However, Haizao is less fortunate. She has a miscarriage and her uterus removed while Song dies in a car accident. Online responses from the audience praise Dwelling for its penetrating and realistic insights into the complex web of familial relationships navigated by Chinese people living in a China under transformation (Xiao, “Woju”). Dwelling was taken off the air when a SARFT official criticised the drama for violating state-endorsed “cultural standards” in its explicit discussions of sex and negative portrayals of government officials (Hung, “State” 156). However, the show continued to be streamed online and it has been viewed and downloaded more than 100 million times (Yu 34). In Lawyers, Luo Li and Chi Haidong are two competing divorce lawyers in Beijing who finally tie the knot. Chi was a happily married man before catching his wife with her lover. Newly divorced, he moves into the same apartment building as Luo and the drama focuses on a series of cases they handle, most of which involve extramarital affairs. Lawyers has been viewed more than 1.6 billion times online (v.qq.com) and received the China Huading award for “favourite television drama” in 2015. Although these dramas contain some conventional elements of domestic melodramas, such as extramarital affairs and domestic disputes, they differ from traditional Chinese television dramas because they do not focus on the common trope of fraught mother-in-law and daughter-in-law relationships.Centred on the politics of family ethics, these hugely popular dramas present the transformation in gender norms as a struggle between post-socialist and pre-socialist understandings of femininity. On the one hand, these dramas celebrate the emergence of a post-socialist femininity that is independent, economically successful, and sexually liberated, epitomising this new understanding of womanhood in the figures of single women and mistresses. On the other hand, the dramas portray these post-socialist women in perpetual conflict with wives and mothers who propound a pre-socialist form of femininity that is sexually conservative and defined by familial relationships, and is economically less viable in the market economy. Focusing on depictions of femininity in these dramas, this paper offers a comparative analysis into the extent to which gender norms have been reconfigured in post-socialist China. It approaches these television dramas as a pedagogical device (Brady) and pays particular attention to the ways through which different categories of women interrogated their rights as single women, mistresses, wives, and mothers. In doing so, it illuminates the politics through which a liberal post-socialist femininity unleashed by market transformation is controlled in order to protect the integrity of the family and maintain social order. Post-Socialist Femininity Unleashed: Single Women and Mistresses A woman’s identity is inextricably linked to her marital status in Chinese society. In pre-socialist China, women relied on men as providers and were expected to focus on contributing to her husband’s family (Ebrey and Watson; Wolf and Witke). This pre-socialist positioning of women within the private realm of the family, though reinterpreted, continued to resonate in the socialist period when women were expected to fulfil marital obligations as wives and participate in the public domain as revolutionaries (Evans). While the pressure to marry has not disappeared in post-socialist China, as the derogatory term “leftover women” (single women over the age of 27) indicates, there are now more choices for single women living in metropolitan cities who are highly educated and financially independent. They can choose to remain single, get married, or become mistresses. Single women can be regarded as a threat to wives because the only thing holding them back from becoming mistresses is their morals. The 28-year-old “leftover woman” Luo Li (Lawyers) is presented as morally superior to single women who choose to become mistresses (Luo Meiyuan and Shi Jiang) and therefore deserving of a happy ending because she breaks up with her boss as soon as she discovers he is married. Luo Li quits to set up a law firm with her friend Tang Meiyu. Both women are beautiful, articulate, intelligent, and sexually liberated, symbolising unleashed post-socialist femininity. Part of the comic relief in Lawyers is the subplot of Luo’s mother trying to introduce her to “eligible” bachelors such as the “PhD man” (Episodes 20–21). Luo is unwilling to lower her standards to escape the stigma of being a “leftover woman” and she is rewarded for adhering to her ideals in the end when she convinces the marriage-phobic Chi Haidong to marry her after she rejects a marriage proposal from her newly divorced ex-lover. While Luo Li refuses to remain a mistress, many women do not subscribe to her worldview. Mistresses have existed throughout Chinese history in the form of concubines and courtesans. A wealthy and powerful man was expected to have concubines, who were usually from lower socio-economic backgrounds (Ebrey and Watson; Liu). Mistresses, now referred to as xiaosan, have become a heated topic in post-socialist China where they are regarded as having the power to destroy families by transgressing moral boundaries. Some argue that the phenomenon is a result of the market-driven economy where women who desire a financially stable life use their sexuality to seek rich married men who lust for younger mistresses as symbols of power. Ruth Y.Y. Hung characterises the xiaosan phenomenon as a “horrendous sex trade [that is] a marker of neoliberal market economies in the new PRC” (“Imagination” 100). A comparison of the three dramas reveals a transformation in the depiction of mistresses over the last decade. While Xiao Li (Divorce) is never “confirmed” as Song Jianping’s mistress, she flirts with him and crosses the boundaries of a professional relationship, posing a threat to the stability of Song’s family life. Although Haizao (Dwelling) is university-educated and has a stable, if low-paying job, she chooses to break up with her earnest caring fiancé to be the mistress of the middle-aged Song Siming who offers her material benefits in the form of “loans” she knows she will never be able to repay, a fancy apartment to live in, and other “gifts” such as dining at expensive restaurants and shopping at big malls. While the fresh-faced Haizao exhibits a physical transformation after becoming Song’s mistress, demonstrated through her newly permed hair coupled with an expensive red coat, mistresses in Lawyers do not change in this way. Dong Dahai’s mistress, the voluptuous Luo Meiyuan is already a successful career woman who flaunts her perfect makeup, long wavy hair, and body-hugging dresses (Episodes 12–26). She exudes sexual confidence but her relationship is not predicated on receiving financial favours in return for sexual ones. She tells Dong’s wife that the only “third person” in a relationship is the “unloved” one (Episode 15). Another mistress who challenges old ideas of the power dynamic of the rich man and financially reliant young woman is the divorced Shi Jiang, Tang Meiyu’s former classmate, who becomes the mistress of Tang’s husband (Cao Qiankun) without any moral qualms, even though she knows that her friend is pregnant with his child. A powerful businesswoman, Shi is the owner of a high-end bar that Cao frequents after losing his job. Unable to tell his wife the truth, he spends most days wandering around and is unable to resist Shi’s advances because she claims to have loved him since their university days and that she understands him. In this relationship, Shi has taken on the role traditionally assigned to men: she is the affluent powerful one who is able to manipulate the downtrodden unemployed man by “lending” him money in his time of need, offering him a job at her bar (Episode 17), and eventually finding him a new job through her connections (Episodes 23–24). When Cao leaves home after Tang finds out about the affair, Shi provides him with a place to stay (Episode 34). Because the viewers are positioned to root for Tang due to her role as the female lead’s best friend, Shi is immediately set up as one of the villains, although she is portrayed in a more sympathetic light after she reveals to Cao that she was forced to give up her son to her ex-husband in America (who cheated on her) in order to finalise her divorce (Episode 29).The portrayal of different mistresses in Lawyers signals a transformation in the representation of gender compared to Divorce and Dwelling, because the women are less naïve than Haizao, financially well-off because of their business acumen, and much more outspoken and determined to fight for what they want. On the surface these women are depicted as more liberated and free from gender hierarchies and sexual oppression. Hung describes xiaosan as “an active if constrained agent . . . whose new mode of life has become revealingly defensible and publicly acceptable in socioeconomic terms that reflect the moral changes that follow economic reforms” (“State” 166). However, the closure of these storylines suggest that although more complex reasons for becoming a mistress have been explored in the new drama, mistresses are still regarded as a threat to social stability and therefore punished, challenging Hung’s argument about the “acceptability” of mistresses in post-socialist China. Post-Socialist Femininity Restrained: Wives and MothersCountering these liberal forms of post-socialist femininity are portrayals of righteous wives and exemplary mothers. These depictions articulate a moral positioning grounded in pre-socialist and socialist understandings of a woman’s place in Chinese society. These portrayals of moral women check the transgressive powers of single women and mistresses with the potential to break families up. More importantly, they remind the audience of desired gender norms that retain the integrity of the family and anchor a society undergoing rapid transformation.The three dramas portray wives who are stridently righteous in their confrontations with women they perceive as a threat to their families. These women find moral justification for the violence they inflict on transgressors from cultural understandings of their rights as wives. Lin Xiaofeng (Divorce) repeatedly challenges Xiao Li to explain the “logic” underlying her actions when she discovers that Xiao accompanied Song Jianping to a wedding (Episode 14). The “logic” Lin refers to is a cultural understanding that it is her right as wife to accompany Song to public events and not Xiao’s. By transgressing this moral boundary, Xiao accords Lin the moral authority to cast doubt on her abilities as a doctor in a public confrontation. It also provides moral justification for Lin to slap Xiao when she suggests that Lin is an embarrassment to her husband, an argument that underscores Lin’s failure and challenges her moral authority as wife. Jiang Miaomiao (Dwelling) draws on similar cultural understandings when she appears at the apartment Haizao shares with Song Siming (Episode 33). Jiang positions herself in the traditional role of a wife as a household manager (Ebrey) whose responsibilities include paying Song’s mistresses. She puts Haizao into a subordinate position by arguing that since Haizao is less than a mistress and slightly better than a prostitute, she is not worth the money Song has given her. When Haizao refuses to return the money a tussle ensues, causing Haizao to have a miscarriage. Likewise, Miao Jinxiu (Lawyers) draws on similar cultural understandings of a wife’s position when she laments popular arguments that depict mistresses such as Luo Meiyuan as usurping the superior position of wives like herself who are less attractive and able to navigate the market economy. Miao describes these arguments as “inverting black into white” (Episode 19). She publicly humiliates Luo by throwing paint on her at a charity event (Episode 17) and covers Luo’s car with posters labelling Luo a “slut,” “prostitute,” and “shameless” (Episode 18). Miao succeeds in “winning” her husband back. The public violence Miao inflicts on Luo and her success in protecting her marriage are struggles to reinforce the boundaries defining the categories of wife and mistress as these limits become increasingly challenged in China. In contrast to the violent strategies that Lin, Jiang, and Miao adopt, Tang Meiyu resists Shi Jiang’s destructive powers by reminding her errant husband of the emotional warmth of their family. She asks him, “Do you still remember telling me what the nicest sound is at home?” For Cao, the best sounds are Tang’s laughter, their baby’s cries, the sound of the washing machine, and the flushing of their leaky toilet (Episode 43). The couple reconciles and even wins a lottery that cements their “happy ending.” By highlighting the warmth of their family, Tang reminds Cao of her rightful place as wife, restrains Shi from breaking up the couple, and protects the integrity of the family. It is by drawing on deeply entrenched cultural understandings of the rights of wives that these women find the moral authority to challenge, restrain, and control the transgressive powers of mistresses and single women. The dramas’ portrayals of mothers further reinforce the sense that there is a need to restrain liberal forms of post-socialist femininity embodied by errant daughters who transgress the moral boundaries of the family. Lin Xiaofeng’s mother (Divorce) assumes the role of the forgiving wife and mother. She not only forgives Lin’s father for having an affair but raises Lin, her husband’s love child, as her own (Episode 23). On her deathbed, she articulates the values underlying her acceptance of this transgression, namely that one needs to be “a little kinder, more tolerant, and a little muddleheaded” when dealing with matters of the family. Her forgiveness bears fruit in the form of the warm companionship and support she enjoys with Lin’s father. This sends a strong pedagogical message to the audience that it is possible for a marriage to remain intact if one is willing to forgive. In contrast, Haizao’s mother (Dwelling) adopts the role of the disciplinary mother. She attempts to beat Haizao with a coat hanger when she finds out that her daughter is pregnant with Song Siming’s child (Episode 31). She describes Haizao’s decision as “the wrong path” and is emphatic that abortion is the only way to right this wrong. She argues that abortion will allow her daughter to start life anew in a relationship she describes as “open and aboveboard,” which will culminate in marriage. When Haizao rejects her mother’s disciplining, her lover dies in a car accident and she has a miscarriage. She loses her ability to speak for two months after these double tragedies and pays the ultimate price, losing her reproductive abilities. Luo Li’s mother (Lawyers), Li Chunhua, extends this pedagogical approach by adopting the role of public counsellor as a talk show host. Li describes Luo’s profession as “wicked” because it focuses on separating the family (Episode 9). Instead, she promotes reconciliation as an alternative. She counsels couples to remain together by propounding traditional family values, such as the need for daughters-in-law to consider the filial obligations of sons when managing their relationship with their mothers-in-law (Episode 25). Her rising ratings and the effectiveness of her strategy in bringing estranged couples like Miao Jinxiu and Dong Dahai back together (Episode 26) challenges the transgressive powers of mistresses by preventing the separation of families. More importantly, as with Haizao’s and Lin’s mothers, the moral force of Li’s position and the alternatives to divorce that she suggests draw on pre-socialist and socialist understandings of family values that underscore the sanctity of marriage to the audience. By reminding errant daughters of deeply embedded cultural standards of what it means to be a woman in Chinese society, these mothers are moral exemplars who restrain the potentiality of daughters becoming mistresses. ConclusionMarket reforms have led to a transformation in understandings of womanhood in post-socialist China. Depictions of mistresses and single women as independent, economically successful, and sexually liberated underscores the emergence of liberal forms of post-socialist femininity. Although adept at navigating the new market economy, these types of post-socialist women threaten the integrity of the family and need to be controlled. Moral arguments articulated by wives and mothers restrain the potentially destructive powers of post-socialist womanhood by drawing on deeply embedded understandings of the rights of women shaped in pre-socialist China. It is by disciplining liberal forms of post-socialist femininity such that they fit back into deeply embedded gender hierarchies that social order is restored. By illuminating the moral politics undergirding relationships between women in post-socialist China, the dramas discussed underscore the continued significance of television as a pedagogical device through which desired gender norms are popularised. These portrayals of the struggles between liberal forms of post-socialist femininity and conservative pre-socialist understandings of womanhood as lived in everyday life serve to communicate the importance of protecting the integrity of the family and maintaining social stability in order for China to continue to pursue development. ReferencesAhern, Emily. “The Power and Pollution of Chinese Women.” Women in Chinese Society. Eds. Margery Wolf et al. Stanford: Stanford UP, 1975. 193–214. Brady, Anne-Marie. Marketing Dictatorship: Propaganda and Thought Work in Contemporary China. Lanham: Rowman & Littlefield, 2007. China Huading Award. “Top 100 TV Series Satisfaction Survey.” 9 Aug. 2015. Chinese Style Divorce. Writ. Wang Hailing. Dir. 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Concentrations of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in settled house dust and road dust samples collected from a core urban area of Hanoi. Levels of PAHs ranged from 830 to 3500 (median 2000) ng/g in house dust, and from 1400 to 4700 (median 1700) ng/g in road dust. Concentrations of PAHs in dust samples of this study were within the moderate range as compared with those from other countries in the world. Toxic equivalents to benzo[a]pyrene (BaP-EQs) in our samples ranged from 81 to 850 (median 330) ng BaP-EQ/g with principal contributors as BaP and dibenz[a,h]anthracene, which accounted for 69% to 93% of BaP-EQs. In almost all the samples, proportions of high-molecular-weight PAHs (HMW-PAHs with 4–6 rings) were higher than those of low-molecular-weight PAHs (LMW-PAHs with 2–3 rings), suggesting emission sources from combustion processes rather than direct contamination by petrogenic sources. 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IntroductionIn this article, I set out to accomplish two tasks. The first is to map coffee and cafés in Mainland China in different historical periods. The second is to focus on coffee and cafés in the socio-cultural milieu of contemporary China in order to understand the symbolic value of the emerging coffee/café-scape. Cafés, rather than coffee, are at the centre of this current trend in contemporary Chinese cities. With instant coffee dominating as a drink, the Chinese have developed a cultural and social demand for cafés, but have not yet developed coffee palates. Historical Coffee Map In 1901, coffee was served in a restaurant in the city of Tianjin. This restaurant, named Kiessling, was run by a German chef, a former solider who came to China with the eight-nation alliance. At that time, coffee was reserved mostly for foreign politicians and military officials as well as wealthy businessmen—very few ordinary Chinese drank it. (For more history of Kiessling, including pictures and videos, see Kiessling). Another group of coffee consumers were from the cultural elites—the young revolutionary intellectuals and writers with overseas experience. It was almost a fashion among the literary elite to spend time in cafés. However, this was negatively judged as “Western” and “bourgeois.” For example, in 1932, Lu Xun, one of the most important twentieth century Chinese writers, commented on the café fashion during 1920s (133-36), and listed the reasons why he would not visit one. He did not drink coffee because it was “foreigners’ food”, and he was too busy writing for the kind of leisure enjoyed in cafés. Moreover, he did not, he wrote, have the nerve to go to a café, and particularly not the Revolutionary Café that was popular among cultural celebrities at that time. He claimed that the “paradise” of the café was for genius, and for handsome revolutionary writers (who he described as having red lips and white teeth, whereas his teeth were yellow). His final complaint was that even if he went to the Revolutionary Café, he would hesitate going in (Lu Xun 133-36). From Lu Xun’s list, we can recognise his nationalism and resistance to what were identified as Western foods and lifestyles. It is easy to also feel his dissatisfaction with those dilettante revolutionary intellectuals who spent time in cafés, talking and enjoying Western food, rather than working. In contrast to Lu Xun’s resistance to coffee and café culture, another well-known writer, Zhang Ailing, frequented cafés when she lived in Shanghai from the 1920s to 1950s. She wrote about the smell of cakes and bread sold in Kiessling’s branch store located right next to her parents’ house (Yuyue). Born into a wealthy family, exposed to Western culture and food at a very young age, Zhang Ailing liked to spend her social and writing time in cafés, ordering her favourite cakes, hot chocolate, and coffee. When she left Shanghai and immigrated to the USA, coffee was an important part of her writing life: the smell and taste reminding her of old friends and Shanghai (Chunzi). However, during Zhang’s time, it was still a privileged and elite practice to patronise a café when these were located in foreign settlements with foreign chefs, and served mainly foreigners, wealthy businessmen, and cultural celebrities. After 1949, when the Chinese Communist Party established the People’s Republic of China, until the late 1970s, there were no coffee shops in Mainland China. It was only when Deng Xiaoping suggested neo-liberalism as a so-called “reform-and-open-up” economic policy that foreign commerce and products were again seen in China. In 1988, ten years after the implementation of Deng Xiaoping’s policy, the Nestlé coffee company made the first inroads into the mainland market, featuring homegrown coffee beans in Yunnan province (China Beverage News; Dong; ITC). Nestlé’s bottled instant coffee found its way into the Chinese market, avoiding a direct challenge to the tea culture. Nestlé packaged its coffee to resemble health food products and marketed it as a holiday gift suitable for friends and relatives. As a symbol of modernity and “the West”, coffee-as-gift meshed with the traditional Chinese cultural custom that values gift giving. It also satisfied a collective desire for foreign products (and contact with foreign cultures) during the economic reform era. Even today, with its competitively low price, instant coffee dominates coffee consumption at home, in the workplace, and on Chinese airlines. While Nestlé aimed their product at native Chinese consumers, the multinational companies who later entered China’s coffee market, such as Sara Lee, mainly targeted international hotels such as IHG, Marriott, and Hyatt. The multinationals also favoured coffee shops like Kommune in Shanghai that offered more sophisticated kinds of coffee to foreign consumers and China’s upper class (Byers). If Nestlé introduced coffee to ordinary Chinese families, it was Starbucks who introduced the coffee-based “third space” to urban life in contemporary China on a signficant scale. Differing from the cafés before 1949, Starbucks stores are accessible to ordinary Chinese citizens. The first in Mainland China opened in Beijing’s China World Trade Center in January 1999, targeting mainly white-collar workers and foreigners. Starbucks coffee shops provide a space for informal business meetings, chatting with friends, and relaxing and, with its 500th store opened in 2011, dominate the field in China. Starbucks are located mainly in the central business districts and airports, and the company plans to have 1,500 sites by 2015 (Starbucks). Despite this massive presence, Starbucks constitutes only part of the café-scape in contemporary Chinese cities. There are two other kinds of cafés. One type is usually located in universities or residential areas and is frequented mainly by students or locals working in cultural professions. A representative of this kind is Sculpting in Time Café. In November 1997, two years before the opening of the first Starbucks in Beijing, two newlywed college graduates opened the first small Sculpting in Time Café near Beijing University’s East Gate. This has been expanded into a chain, and boasts 18 branches on the Mainland. (For more about its history, see Sculpting in Time Café). Interestingly, both Starbucks and Sculpting in Time Café acquired their names from literature, Starbucks from Moby Dick, and Sculpting in Time from the Russian filmmaker Andrei Tarkovsky’s film diary of the same name. For Chinese students of literature and the arts, drinking coffee is less about acquiring more energy to accomplish their work, and more about entering a sensual world, where the aroma of coffee mixes with the sounds from the coffee machine and music, as well as the lighting of the space. More importantly, cafés with this ambience become, in themselves, cultural sites associated with literature, films, and music. Owners of this kind of café are often lovers of foreign literatures, films, and cultures, and their cafés host various cultural events, including forums, book clubs, movie screenings, and music clubs. Generally speaking, coffee served in this kind of café is simpler than in the kind discussed below. This third type of café includes those located in tourist and entertainment sites such as art districts, bar areas, and historical sites, and which are frequented by foreign and native tourists, artists and other cultural workers. If Starbucks cultivates a fast-paced business/professional atmosphere, and Sculpting in Time Cafés an artsy and literary atmosphere, this third kind of café is more like an upscale “bar” with trained baristas serving complicated coffees and emphasising their flavour. These coffee shops are more expensive than the other kinds, with an average price three times that of Starbucks. Currently, cafés of this type are found only in “first-tier” cities and usually located in art districts and tourist areas—such as Beijing’s 798 Art District and Nanluo Guxiang, Shanghai’s Tai Kang Road (a.k.a. “the art street”), and Hangzhou’s Westlake area. While Nestlé and Starbucks use coffee beans grown in Yunnan provinces, these “art cafés” are more inclined to use imported coffee beans from suppliers like Sara Lee. Coffee and Cafés in Contemporary China After just ten years, there are hundreds of cafés in Chinese cities. Why has there been such a demand for coffee or, more accurately, cafés, in such a short period of time? The first reason is the lack of “third space” environments in Mainland China. Before cafés appeared in the late 1990s, stores like KFC (which opened its first store in 1987) and McDonald’s (with its first store opened in 1990) filled this role for urban residents, providing locations where customers could experience Western food, meet friends, work, or read. In fact, KFC and McDonald’s were once very popular with college students looking for a place to study. Both stores had relatively clean food environments and good lighting. They also had air conditioning in the summer and heating in the winter, which are not provided in most Chinese university dormitories. However, since neither chain was set up to be a café and customers occupying seats for long periods while ordering minimal amounts of food or drink affected profits, staff members began to indirectly ask customers to leave after dining. At the same time, as more people were able to afford to eat at KFC and McDonald’s, their fast foods were also becoming more and more popular, especially among young people. As a consequence, both types of chain restaurant were becoming noisy and crowded and, thus, no longer ideal for reading, studying, or meeting with friends. Although tea has been a traditional drink in Chinese culture, traditional teahouses were expensive places more suitable for business meetings or for the cultural or intellectual elite. Since almost every family owns a tea set and can readily purchase tea, friends and family would usually make and consume tea at home. In recent years, however, new kinds of teahouses have emerged, similar in style to cafés, targeting the younger generation with more affordable prices and a wider range of choices, so the lack of a “third space” does not fully explain the café boom. Another factor affecting the popularity of cafés has been the development and uptake of Internet technology, including the increasing use of laptops and wireless Internet in recent years. The Internet has been available in China since the late 1990s, while computers and then laptops entered ordinary Chinese homes in the early twenty-first century. The IT industry has created not only a new field of research and production, but has also fostered new professions and demands. Particularly, in recent years in Mainland China, a new socially acceptable profession—freelancing in such areas as graphic design, photography, writing, film, music, and the fashion industry—has emerged. Most freelancers’ work is computer- and Internet-based. Cafés provide suitable working space, with wireless service, and the bonus of coffee that is, first of all, somatically stimulating. In addition, the emergence of the creative and cultural industries (which are supported by the Chinese government) has created work for these freelancers and, arguably, an increasing demand for café-based third spaces where such people can meet, talk and work. Furthermore, the flourishing of cafés in first-tier cities is part of the “aesthetic economy” (Lloyd 24) that caters to the making and selling of lifestyle experience. Alongside foreign restaurants, bars, galleries, and design firms, cafés contribute to city branding, and link a city to the global urban network. Cafés, like restaurants, galleries and bars, provide a space for the flow of global commodities, as well as for the human flow of tourists, travelling artists, freelancers, and cultural specialists. Finally, cafés provide a type of service that contributes to friendly owner/waiter-customer relations. During the planned-economy era, most stores and hotels in China were State-owned, staff salaries were not related to individual performance, and indifferent (and even unfriendly) service was common. During the economic reform era, privately owned stores and shops began to replace State-owned ones. At the same time, a large number of people from the countryside flowed into the cities seeking opportunities. Most had little if any professional training and so could only find work in factories or in the service industry. However, most café employees are urban, with better educational backgrounds, and many were already familiar with coffee culture. In addition, café owners, particularly those of places like Sculpting in Time Cafe, often invest in creating a positive, community atmosphere, learning about their customers and sharing personal experiences with their regular clients. This leads to my next point—the generation of the 1980s’ need for a social community. Cafés’ Symbolic Value—Community A demand for a sense of community among the generation of the 1980s is a unique socio-cultural phenomenon in China, which paradoxically co-exists with their desire for individualism. Mao Zedong started the “One Child Policy” in 1979 to slow the rapid population growth in China, and the generations born under this policy are often called “the lonely generations,” with both parents working full-time. At the same time, they are “the generation of me,” labelled as spoiled, self-centred, and obsessed with consumption (de Kloet; Liu; Rofel; Wang). The individuals of this generation, now aged in their 20s and 30s, constitute the primary consumers of coffee in China. Whereas individualism is an important value to them, a sense of community is also desirable in order to compensate for their lack of siblings. Furthermore, the 1980s’ generation has also benefitted from the university expansion policy implemented in 1999. Since then, China has witnessed a surge of university students and graduates who not only received scientific and other course-based knowledge, but also had a better chance to be exposed to foreign cultures through their books, music, and movies. With this interesting tension between individualism and collectivism, the atmosphere provided by cafés has fostered a series of curious temporary communities built on cultural and culinary taste. Interestingly, it has become an aspiration of many young college students and graduates to open a community-space style café in a city. One of the best examples is the new Henduoren’s (Many People’s) Café. This was a project initiated by Wen Erniu, a recent college graduate who wanted to open a café in Beijing but did not have sufficient funds to do so. She posted a message on the Internet, asking people to invest a minimum of US$316 to open a café with her. With 78 investors, the café opened in September 2011 in Beijing (see pictures of Henduoren’s Café). In an interview with the China Daily, Wen Erniu stated that, “To open a cafe was a dream of mine, but I could not afford it […] We thought opening a cafe might be many people’s dream […] and we could get together via the Internet to make it come true” (quoted in Liu 2011). Conclusion: Café Culture and (Instant) Coffee in China There is a Chinese saying that, if you hate someone—just persuade him or her to open a coffee shop. Since cafés provide spaces where one can spend a relatively long time for little financial outlay, owners have to increase prices to cover their expenses. This can result in fewer customers. In retaliation, cafés—particularly those with cultural and literary ambience—host cultural events to attract people, and/or they offer food and wine along with coffee. The high prices, however, remain. In fact, the average price of coffee in China is often higher than in Europe and North America. For example, a medium Starbucks’ caffè latte in China averaged around US$4.40 in 2010, according to the price list of a Starbucks outlet in Shanghai—and the prices has recently increased again (Xinhua 2012). This partially explains why instant coffee is still so popular in China. A bag of instant Nestlé coffee cost only some US$0.25 in a Beijing supermarket in 2010, and requires only hot water, which is accessible free almost everywhere in China, in any restaurant, office building, or household. As an habitual, addictive treat, however, coffee has not yet become a customary, let alone necessary, drink for most Chinese. Moreover, while many, especially those of the older generations, could discern the quality and varieties of tea, very few can judge the quality of the coffee served in cafés. As a result, few Mainland Chinese coffee consumers have a purely somatic demand for coffee—craving its smell or taste—and the highly sweetened and creamed instant coffee offered by companies like Nestlé or Maxwell has largely shaped the current Chinese palate for coffee. Ben Highmore has proposed that “food spaces (shops, restaurants and so on) can be seen, for some social agents, as a potential space where new ‘not-me’ worlds are encountered” (396) He continues to expand that “how these potential spaces are negotiated—the various affective registers of experience (joy, aggression, fear)—reflect the multicultural shapes of a culture (its racism, its openness, its acceptance of difference)” (396). Cafés in contemporary China provide spaces where one encounters and constructs new “not-me” worlds, and more importantly, new “with-me” worlds. While café-going communicates an appreciation and desire for new lifestyles and new selves, it can be hoped that in the near future, coffee will also be appreciated for its smell, taste, and other benefits. Of course, it is also necessary that future Chinese coffee consumers also recognise the rich and complex cultural, political, and social issues behind the coffee economy in the era of globalisation. 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This study uses an in silico screening docking model to evaluate the ACE2 inhibitory activity of natural compounds and drugs. The study collected 49 compounds and evaluated the ACE2 inhibitory effect in silico. The study results show that 11 out of the 49 compounds had stronger inhibitory activity on ACE2 than MLN-4760. Lipinski’s rule of five criteria and predictive pharmacokinetic-toxicity analysis show that eight compounds including quercetin, galangin, quisinostat, fluprofylline, spirofylline, RS 504393, TNP and GNF-5 had drug-likeness. These compounds could be potential drug for the Covid-19 treatment. Keywords SARS-CoV-2S, Covid-19, ACE2, molecular docking, in silico. References [[1] C. Wang, P.W. Horby, F.G. Hayden, G.F. Gao. A novel coronavirus outbreak of global health concern. The Lancet 395(10223) (2020) 470.[2] WHO. WHO Coronavirus Disease (COVID-19) Dashboard. WHO, 2020.[3] N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, et al. 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The globe is engulfed by one of the most extensive public health crises as COVID-19 has become a leading cause of death worldwide. COVID-19 was first detected in Wuhan, China, in December 2019, causing the severe acute respiratory syndrome. This review discusses issues related to Covid-19 vaccines, such as vaccine development targets, vaccine types, efficacy, limitations and development prospects. Keywords: Covid-19, SARS-CoV-2, vaccine, spike protein. References [1] C. Wang, P. W. Horby, F. G. Hayden, G. F. Gao, A Novel Coronavirus Outbreak of Global Health Concern, The Lancet, Vol. 395, No. 10223, 2020, pp. 470-473, https://doi.org/10.1016/S0140-6736(20)30185-9.[2] T. Singhal, A Review of Coronavirus Disease-2019 (COVID-19), The Indian Journal of Pediatrics, Vol. 87, 2020, pp. 281-286, https://doi.org/10.1007/s12098-020-03263-6.[3] World Health Organization, WHO Coronavirus (COVID-19) Dashboard, https://covid19.who.int/, (accessed on: August 21st, 2021).[4] A. 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We review our recent work on optical biosensors based on microring resonators (MRR) integrated with 4x4 multimode interference (MMI) couplers for multichannel and highly sensitive chemical and biological sensors. The proposed sensor structure has advantages of compactness, high sensitivity compared with the reported sensing structures. By using the transfer matrix method (TMM) and numerical simulations, the designs of the sensor based on silicon waveguides are optimized and demonstrated in detail. We applied our structure to detect glucose and ethanol concentrations simultaneously. A high sensitivity of 9000 nm/RIU, detection limit of 2x10-4 for glucose sensing and sensitivity of 6000nm/RIU, detection limit of 1.3x10-5 for ethanol sensing are achieved. Keywords Biological sensors, chemical sensors, optical microring resonators, high sensitivity, multimode interference, transfer matrix method, beam propagation method (BPM), multichannel sensor References [1] Vittorio M.N. 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Indonesian EFL students faced online teaching and learning in such a rapid process. Therefore, this research was carried out to search for EFL students in Indonesia about their responses on teaching and learning online. This research applied the action research method with the paradigm of quantitative descriptive approach. Data for this research was collected via an online questionnaire, distributed to one class size sample consisting of 32 students in the even semester of the 2019/2020 academic year at one of the private colleges in the West Sumatra province of Indonesia. The data were analysed by descriptive statistics, especially the percentage of each item available in the questionnaire. Findings of this research show that the respondents, or the students, had their evaluation toward the online teaching and learning. 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