Journal articles on the topic 'Guo Feng'
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1
Chen, Bing, and Bo Ning. "Hamilton cycles in almost distance-hereditary graphs." Open Mathematics 14, no. 1 (January 1, 2016): 19–28. http://dx.doi.org/10.1515/math-2016-0003.
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AbstractLet G be a graph on n ≥ 3 vertices. A graph G is almost distance-hereditary if each connected induced subgraph H of G has the property dH(x, y) ≤ dG(x, y) + 1 for any pair of vertices x, y ∈ V(H). Adopting the terminology introduced by Broersma et al. and Čada, a graph G is called 1-heavy if at least one of the end vertices of each induced subgraph of G isomorphic to K1,3 (a claw) has degree at least n/2, and is called claw-heavy if each claw of G has a pair of end vertices with degree sum at least n. In this paper we prove the following two theorems: (1) Every 2-connected, claw-heavy and almost distance-hereditary graph is Hamiltonian. (2) Every 3-connected, 1-heavy and almost distance-hereditary graph is Hamiltonian. The first result improves a previous theorem of Feng and Guo [J.-F. Feng and Y.-B. Guo, Hamiltonian cycle in almost distance-hereditary graphs with degree condition restricted to claws, Optimazation57 (2008), no. 1, 135–141]. For the second result, its connectedness condition is sharp since Feng and Guo constructed a 2-connected 1-heavy graph which is almost distance-hereditary but not Hamiltonian.
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Dorofiéiéva-Lichtmann, Viéra V. "Les Vents des Royaumes (Guo feng) : un schéma géographique." Extrême orient Extrême occident 13, no. 13 (1991): 59–91. http://dx.doi.org/10.3406/oroc.1991.1043.
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Bouali, Mohamed. "On an open problem of Feng Qi and Bai-Ni Guo." Mathematical Inequalities & Applications, no. 1 (2020): 61–69. http://dx.doi.org/10.7153/mia-2020-23-05.
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Chen, Lizhen. "Literature for Children and Beyond: Historicising the Fantastic Utopia in ‘The Country of the Red Heart’." International Research in Children's Literature 15, no. 1 (February 2022): 15–26. http://dx.doi.org/10.3366/ircl.2022.0427.
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As a major voice in children's literature in China, Feng Zikai uses his own life experience and the historical context of contemporary wars to negotiate the Chinese cultural myth of ‘The Peach Blossom Spring’ [Tao Hua Yuan]. ‘The Country of the Red Heart’ [Chi Xin Guo] is a fantastic utopia that exists parallel to our world, revealing his efforts to depict a pastoral dreamland and his subsequent disillusion in the face of the horrors of war and political strife. It is a story of fantasy as well as a political move on the part of Feng Zikai to address the historical milieu of China during the time of World War II, the Civil War, and the Korean War. Feng Zikai goes beyond the combination of Chinese-style cartoon [manhua] drawings and grotesquely fanciful plot as a war story for children. It is a modern political parable that demonstrates the vulnerability of his utopia in the first part of twentieth-century China.
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Qi, Jian-ming, Qiu-hui Chen, Wei-ling Xiong, and Wen-jun Yuan. "A Note about the General Meromorphic Solutions of the Fisher Equation." Mathematical Problems in Engineering 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/793834.
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We employ the complex method to obtain the general meromorphic solutions of the Fisher equation, which improves the corresponding results obtained by Ablowitz and Zeppetella and other authors (Ablowitz and Zeppetella, 1979; Feng and Li, 2006; Guo and Chen, 1991), andwg,i(z)are new general meromorphic solutions of the Fisher equation forc=±5i/6.Our results show that the complex method provides a powerful mathematical tool for solving great many nonlinear partial differential equations in mathematical physics.
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FU, Xiao-dong. "The Ten Methods Used by Dr. CHEN Guo-feng for Treating Allergic Rhinitis." Journal of Traditional Chinese Medicine 30, no. 3 (September 2010): 206–10. http://dx.doi.org/10.1016/s0254-6272(10)60042-8.
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Jia, Chong, Chang Dong Li, Sheng Yi Ma, and Ji He Zhou. "Studies on the Kinematics of Chinese Elite Man Hammer Athlete Throwing Technology." Applied Mechanics and Materials 568-570 (June 2014): 1930–33. http://dx.doi.org/10.4028/www.scientific.net/amm.568-570.1930.
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The purpose of this study is to provide the theoretical basis for the teaching and training of the hammer throwing and improve Chinese man hammer to reach world-class as soon as possible. This paper made a 3-D camera resolution on the top three men's hammer throwers in 2012 China Long Throw Open (Shizhu Wang, Kun Guo and Xiao Feng). With the comparative analysis on the related kinematic parameters of the world elite men's hammer throwers, it presents the main problems and gaps in China men's hammer throwers motion technology.
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Martin, Philippe. "Xingyuan Feng, Christer Ljungwall and Sujian Guo, The Political Economy of China’s Great Transformation." Journal of Chinese Political Science 22, no. 4 (September 30, 2017): 695–96. http://dx.doi.org/10.1007/s11366-017-9519-2.
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Mason, Peter G. "Fang-Ho Wan, Jian-Ying Guo, and Feng Zhang: Research on biological invasions in China." Biological Invasions 13, no. 2 (July 8, 2010): 527–29. http://dx.doi.org/10.1007/s10530-010-9832-6.
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Yuan, Wenjun, Qiuhui Chen, Jianming Qi, and Yezhou Li. "The General Traveling Wave Solutions of the Fisher Equation with Degree Three." Advances in Mathematical Physics 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/657918.
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We employ the complex method to research the integrality of the Fisher equations with degree three. We obtain the sufficient and necessary condition of the integrable of the Fisher equations with degree three and the general meromorphic solutions of the integrable Fisher equations with degree three, which improves the corresponding results obtained by Feng and Li (2006), Guo and Chen (1991), and Ağırseven and Öziş (2010). Moreover, allwg,1(z)are new general meromorphic solutions of the Fisher equations with degree three forc=±3/2. Our results show that the complex method provides a powerful mathematical tool for solving a large number of nonlinear partial differential equations in mathematical physics.
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Obenchain, Diane B. "Continuity–Guo Xiang, Chan, Cheng-Zhu Lixue, New Realism, Marxism–Feng Youlan’s Discernment of the Way." Journal of Chinese Philosophy 21, no. 3-4 (February 10, 1994): 481–519. http://dx.doi.org/10.1163/15406253-0210304018.
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Guo, Feng-Biao. "Editorial [Hot Topic: Replicating Strand Asymmetry in Bacterial and Eukaryotic Genomes (Guest Editor: Feng-Biao Guo)]." Current Genomics 13, no. 1 (March 1, 2012): 2–3. http://dx.doi.org/10.2174/138920212799034794.
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OBENCHACM, DIANE B. "CONTINUITY-GUO X1ANG, CHAN, CHENG-ZHU LIXUE, NEW REALISM, MARXISM-FENG YOULANTS DISCERNMENT OF THE WAY." Journal of Chinese Philosophy 21, no. 3-4 (September 1994): 481–519. http://dx.doi.org/10.1111/j.1540-6253.1994.tb00699.x.
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Zhou, Qi, Chun Lin He, and Qing Kui Cai. "Effect of Al2O3 Powders on Properties of Electrodeposited Ni Matrix." Advanced Materials Research 79-82 (August 2009): 631–34. http://dx.doi.org/10.4028/www.scientific.net/amr.79-82.631.
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[1] Chen Li, Wang Li-Ping, Zeng Zhi-Xiang, Xu Tao. Surf Coat Technol, 2006,201:599-605. doi:10.1016/j.surfcoat.2005.12.008 [2] Wei X Y, Zhu Z G, Prewett P D, Jiang K. Microelectron Eng, 2007,84:1256-1259. doi:10.1016/j.mee.2007.01.218 [3] Thiemig Denny, Lange Ronny, Bund Andreas. Electrochim Acta, 2007,52:7362-7371. doi:10.1016/j.electacta.2007.06.009 [4] Chang L M, An M Z, Guo H F, Shi S Y. Appl Surf Sci, 2006,53:2132-2137. doi:10.1016/j.apsusc.2006.04.018 [5] Feng Q Y, Li T J, Zhang Z T, Zhang J, Liu M, Jin J Z. Surf Coat Technol, 2007,201:6247-6252. doi:10.1016/j.surfcoat.2006.11.019 [6] Du L Z, Xu B S, Dong S Y. Wear, 2004,257:1058–1063. doi:10.1016/j.wear.2004.07.003
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Lawrence, Aamna, and Hui Ho Vanessa Chang. "Minimally invasive neural stimulation with a novel ultra-sensitive step function opsin: implications and future directions." Journal of Neurophysiology 124, no. 5 (November 1, 2020): 1312–14. http://dx.doi.org/10.1152/jn.00472.2020.
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Optogenetics has become a popular tool to probe the link between neural circuits and behavior, since the technique was first introduced in 2005. Recently, Gong et al. (Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CWH, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. Neuron 107: 38–51, 2020) developed an ultra-sensitive step-function opsin capable of activating any region of the mouse brain and cortical areas in macaques with external illumination, thus aiming toward minimally invasive light delivery. In this article, we highlight and discuss the new opsin's potential in nonhuman primate research.
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Guo, Songtao, Yantao Li, and Xiaohui Hua. "(G,s)-Transitive Graphs of Valency 7." Algebra Colloquium 23, no. 03 (June 20, 2016): 493–500. http://dx.doi.org/10.1142/s100538671600047x.
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Let X be a finite simple undirected graph and G an automorphism group of X. If G is transitive on s-arcs but not on (s+1)-arcs then X is called (G,s)-transitive. Let X be a connected (G,s)-transitive graph of a prime valency p, and Gv the vertex stabilizer of a vertex v ∈ V(X) in G. For the case p=3, the exact structure of Gv has been determined by Djoković and Miller in [Regular groups of automorphisms of cubic graphs, J. Combin. Theory (Ser. B) 29 (1980) 195 – 230]. For the case p=5, all the possibilities of Gv have been given by Guo and Feng in [A note on pentavalent s-transitive graphs, Discrete Math.312 (2012) 2214 – 2216]. In this paper, we deal with the case p=7 and determine the exact structure of the vertex stabilizer Gv.
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陳韻, 陳韻. "《春秋》微言在《新列國志》中的移轉表現淺說." 中正漢學研究 37, no. 37 (June 2021): 157–94. http://dx.doi.org/10.53106/2306036020210600370006.
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<p>處於銜接傳統與現代交替關鍵的明朝時期，人文風景展示著種種轉換的影像，或顯或隱，不論內涵與形式，都在巨細之間透露出相互呼應的消息，尤其是最能反映各類情境的通俗文學，不但吞吐即時訊息，而且提供背景資料，以及追蹤指南。因此，本論文擬連結儒家經典與通俗文學二者，探討傳統思維在時空易移下的吸納與演化。茲以精研《春秋》的「三言」（《喻世明言》、《警世通言》、《醒世恒言》）作者馮夢龍為關注主體，從轉變的角度，結合時代特質、學術取向、社會樣貌、文本體式、生命情理等多重層面，觀察其所撰《新列國志》之中，承載《春秋》的狀態，並尋繹其脈絡與意涵。</p> <p> </p><p>The Ming Dynasty was an era of alternating tradition and modernity. Popular literature was becoming more and more popular, and Feng Meng-long’s Xin Lie Guo Zhi is one of the representatives. This thesis will take Xin Lie Guo Zhi and Confucian classics Chun Que as examples to discuss the acceptance of Confucian thinking in popular literature at that time. The content includes: analysis and comparison of the characteristics of the times, social influence, writing characteristics, and humanistic care of Chun Que and Xin Lie Guo Zhi in angles of historical events, academic development, and literary performance.</p> <p> </p>
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Shaughnessy (夏含夷), Edward L. "A First Reading of the Anhui University Bamboo-Slip Shi Jing." Bamboo and Silk 4, no. 1 (January 28, 2021): 1–44. http://dx.doi.org/10.1163/24689246-00401001.
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Abstract In September, 2019, Anhui University published the first volume of Warring States bamboo-slip manuscripts in its collection. The bamboo slips were purchased by the university in 2015 on the antique market. This volume contains ninety-three slips that correspond with all of or portions of fifty-seven poems in the Guo feng 國風 (Airs of the States) section of the Shi jing 詩經 (Classic of Poetry). The manuscript is written in the script of the ancient state of Chu 楚, and thus presumably was robbed from a tomb somewhere in the territory of that state. This preliminary study of the manuscript presents close readings of six representative poems, comparing the versions in the manuscript with those of the received text. It concludes with consideration of how to understand the textual variants apparent in the manuscript, and also the significance of the manuscript for the composition and especially the transmission of the Shi jing in the pre-Qin period.
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Zhang, Chunyan. "Nature as Refuge in Chinese Film and Literature." International Journal of Social Science Studies 8, no. 4 (June 23, 2020): 163. http://dx.doi.org/10.11114/ijsss.v8i4.4908.
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In the period of 1920s and 1930s, traditional Chinese ideas and aesthetics, although embattled and in the process of being superseded by modern and Western aesthetics, did not totally disappear or die out in Chinese film and literature. For example, the image of nature continued to be constructed for its ability to relieve the misery of humanity. This is demonstrated in the films A Poet at the Edge of the Sea (1927) and Sand Washed by Waves (1936). However, because of social turmoil and turbulence of this period, the peaceful inner spirit as conveyed in the traditional culture seemed unattainable. There were more hints of social struggles in the “utopia”, as shown in the films Little Toy (1933) and Return to Nature (1936). The traditional ideas and aesthetics were also continued by some writers, such as Zhou Zuoren, Feng Wenbing, Yu Pingbo and Wang Tongzhao, who still had close spiritual connections with traditional culture. Sometimes the spirit of the “return to nature” was embedded with another mark of this period: the influence of Western culture, as shown by several of Guo Moruo’s poems.
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Ding, Shuxin, Baoxuan Hu, Xiaowen Jiang, and Qi Zhao. "The Narration of War and the Shaping of Characters in Novels: Taking Jin Yong’s The Demi-Gods and Semi-Devils and The Legend of the Condor Heroes as Examples." Journal of Education, Humanities and Social Sciences 8 (February 7, 2023): 2016–21. http://dx.doi.org/10.54097/ehss.v8i.4636.
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In the Southern Song Dynasty, there was a long confrontation between the Song and the Jin. In the later period, Song and Mongolia combined to destroy Jin, and Song was also conquered by the Mongols. The two novels of Jin Yong analyzed in this paper set in the Song Dynasty as historical background. This paper uses empirical research and literary creation theory to research The Legend of the Condor Heroes and The Demi-Gods and Semi-Devils, and discusses the influence of the war background on the characters of the protagonists Guo Jing, Yang Kang and Qiao Feng, which is reflected in three aspects: identity, views of nation and war, the fate of death. The paper demonstrates that the war profoundly affected the life trajectory of the characters, and the characters could not escape the influence of war. The wars put the three characters in a dilemma of identity choice, which was the most essential dilemma that the characters faced. In the dilemma, all three characters ended their lives in a painful way.
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이은영. "A Study on the Influence of Lie-Guo-Zhi-Zhuan(列國志傳) and Feng-Shen-Yan-Yi (封神演義)." Journal of the research of chinese novels ll, no. 26 (September 2007): 213–31. http://dx.doi.org/10.17004/jrcn.2007..26.013.
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이재홍. "A Study on the Influence of Lie-Guo-Zhi-Zhuan(列國志傳) and Feng-Shen-Yan-Yi (封神演義)." Journal of the research of chinese novels ll, no. 26 (September 2007): 233–70. http://dx.doi.org/10.17004/jrcn.2007..26.014.
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Teulon, D. A. J., and B. Xu. "Chinese language publications are important for understanding the likely impact of brown marmorated stink bug to kiwifruit." New Zealand Plant Protection 70 (July 26, 2017): 316. http://dx.doi.org/10.30843/nzpp.2017.70.75.
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Brown marmorated stink bug (BMSB) is a polyphagous pest originating from Asia but is now established in North America, Europe and recently South America. It has not established in New Zealand but is considered a signi cant biosecurity threat. Surprisingly, there is very little accessible information on its potential impact on kiwifruit, one of New Zealand’s most important horticulture crops. Articles in Chinese characters1,2,3 published in Chinese journals more than a decade ago demonstrate that BMSB is an important kiwifruit pest in China and, therefore, of concern to New Zealand’s kiwifruit industry. However, these articles were unknown to the broader BMSB research community until recently. This example reemphasises the importance of searching Chinese databases with Chinese characters, along with standard searches in international databases, to ensure a comprehensive understanding of biosecurity risks to New Zealand.
Zhang F, Chen Z, Zhang S. 2000. The occurrence and control of Halyomorpha halys in kiwifruit orchards. Northwest Horticulture 2: 38.
Guo X, Shi X. 2003. The biology and integrated management of important kiwifruit pests. China Fruits 1: 45-46.
Feng H. 2007. The occurrence and control of pests in kiwifruit orchards. Northwest Horticulture 12: 22.
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Feng, Xuelei, Fengshan Ma, Haijun Zhao, Gang Liu, and Jie Guo. "Erratum: Feng, X.; Ma, F.; Zhao, H.; Liu, G; Guo, J. Gas Multiple Flow Mechanisms and Apparent Permeability Evaluation in Shale Reservoirs. Sustainability 2019, 11, 2114." Sustainability 11, no. 13 (July 1, 2019): 3623. http://dx.doi.org/10.3390/su11133623.
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Zhang, Dong Dong. "The Political Economy of China's Great Transformation by Xingyuan Feng, Christer Ljungwall, and Sujian Guo Routledge, London, 2017 Pp. xx + 243. ISBN: 978 1 138 94400 8." Asian-Pacific Economic Literature 31, no. 1 (May 2017): 99–101. http://dx.doi.org/10.1111/apel.12184.
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Wang, Guoqian, Zhengcheng Guo, Hongling Chen, Chang Liu, Jinying Ning, and Feng Hao. "Abstract 6182: A comprehensive panel of reporter cell lines to accelerate immune-checkpoint antibody discovery." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6182. http://dx.doi.org/10.1158/1538-7445.am2022-6182.
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Abstract Anti-tumor immune therapy has achieved great success. Antibody drugs targeting PD1/PD-L1 have brought significant benefits for cancer patients. In the post-PD1/PD-L1 era, many novel targets for tumor-related immune modulation have been discovered, and tremendous efforts have been put to develop new biologics for these targets. There is an urgent need for a high-throughput functional system that mimics tumor immune microenvironment to screen antibodies. Equipped with expertise in tumor immunology and cell biology, KYinno has generated a panel of reporter cell lines to accelerate immune-checkpoint antibody discovery. The reporter system includes two types of engineered cell lines, one is CHO-K1 or 293T based aAPC (artificial antigen presenting cell) which provides both stimuli and inhibitor (ligand) signals, and the other one is Jurkat-NFAT-luciferase reporter cell line that over-expresses the drug target (receptor). In this co-culture system, the ligand-receptor complex can induce NFAT inhibitory signals. The functional antibodies can rescue the inhibitory signal by blockage of the ligand-receptor interaction. All the reporter cell lines have been well validated with benchmark antibodies. Currently, the systems cover immune modulation for TIGIT, LILRB1, LILRB2, PVRIG, Lag3, TIM3, NKG2a, NKp30, PD1, NKp46, etc. Citation Format: Guoqian Wang, Zhengcheng Guo, Hongling Chen, Chang Liu, Jinying Ning, Feng Hao. A comprehensive panel of reporter cell lines to accelerate immune-checkpoint antibody discovery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6182.
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Wu, Guojin, Jinming Liang, Feng He, Meng Zhang, Zhengcheng Guo, and Jinying Ning. "Abstract 5301: GDF-15 neutralizing antibody restores cancer-induced cachexia." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5301. http://dx.doi.org/10.1158/1538-7445.am2022-5301.
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Abstract Growth and differentiation factor 15 (GDF-15) is a member of the transforming growth factor β superfamily. Elevated GDF-15 level was often the result of pathological conditions, including autoimmune disease and cancer. Increased GDF-15 caused metabiotic disorders such as anorexia and cachexia, and GDF-15 became an attractive target for metabolic intervention. Here, we developed a humanized GDF-15 neutralizing antibody (H53E5-8V2) from hybridoma of mice immunized with GDF-15-mFc. H53E5-8V2 had high affinity to GDF-15 (Kd=0.05nM), and demonstrated a stronger binding to coated GDF-15-HIS than Ponsegnomab (Pfizer Inc.) with ELISA assay (EC50=0.33nM vs 0.73nM). H53E5-8V2 also had strong binding to cynoGDF15 (EC50=0.3nM). In ELISA blocking assay, H53E5-8V2 disrupted the interaction of GDF-15 and GFRAL with a lower concentration than Ponsegnomab (EC50=0.25nM vs. 0.5nM). In addition, H53E5-8V2 neutralized GDF-15 in the culture medium and blocked GDF-15 induced GFRAL signaling more efficiently than Ponsegnomab in reporter cell assay (EC50=0.13nM vs. 0.27nM). H53E5-8V2 was stable and had a serum half-life of 9 days in mice with a single antibody injection. And it prevented body weight decrease of the mouse with HT1080 xenograft tumor, MC38 overexpressing GDF-15, or subcutaneous injection of protein GDF-15 fused with mouse Fc at C terminal. These results suggested that H53E5-8V2 was a good candidate drug for the treatment of cachexia. Citation Format: Guojin Wu, Jinming Liang, Feng He, Meng Zhang, Zhengcheng Guo, Jinying Ning. GDF-15 neutralizing antibody restores cancer-induced cachexia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5301.
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Huang, Yuan, Feifei Zheng, Huan-Feng Duan, and Qingzhou Zhang. "Closure to “Skeletonizing Pipes in Series within Urban Water Distribution Systems Using a Transient-Based Method” by Yuan Huang, Feifei Zheng, Huan-Feng Duan, Tuqiao Zhang, Xinlei Guo, and Qingzhou Zhang." Journal of Hydraulic Engineering 146, no. 4 (April 2020): 07020004. http://dx.doi.org/10.1061/(asce)hy.1943-7900.0001727.
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Seog Jung, Bong, and Bryan W. Karney. "Discussion of “Skeletonizing Pipes in Series within Urban Water Distribution Systems Using a Transient-Based Method” by Yuan Huang, Feifei Zheng, Huan-Feng Duan, Tuqiao Zhang, Xinlei Guo, and Qingzhou Zhang." Journal of Hydraulic Engineering 146, no. 4 (April 2020): 07020003. http://dx.doi.org/10.1061/(asce)hy.1943-7900.0001728.
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Al Keyyam, Ibrahim, Yousuf S. Mohamed, Helmut Baumgart, Nasser Ghariban, and Abdelmageed Elmustafa. "Microstructure and Mechanical Properties of Rexnbmotaw Thin Films Prepared By RF Magnetron Sputtering." ECS Meeting Abstracts MA2022-02, no. 64 (October 9, 2022): 2356. http://dx.doi.org/10.1149/ma2022-02642356mtgabs.
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High Entropy Alloys (HEAs) and Refractory High-Entropy Alloys (RHEAs) are novel potential materials for high-temperature applications [1]. NbMoTaW, a RHEAs, such as the one in Fig. 1, possess superior mechanical properties, combining high strength, outstanding thermal stability, and resistance to softening at high temperatures [2]. The influence of adding Vanadium [3], Tantalum [4], and Rhenium [5] to NbMoTaW alloys on the bulk mechanical behavior was investigated by the previous studies. In this research, the effect of adding Rhenium with different (Re0, Re0.5, Re1) on the microstructure and the mechanical properties of NbMoTaW thin films will be nvestigated. The larger the enthalpy of mixing in negative values, the higher the binding force between the elements, which has been enhanced with Rhenium addition. As for the entropy of mixing, it increased from 11.53 to 13.38 for Re0 and Re1, respectively. The higher the mixture entropy suggests a more stable solid solution. This is confirmed by calculating the thermodynamic parameters proposed by Yang et. Al [6] where they suggested that a mixture with δ < 6.6 and Ω > 1.1 correspond to solid solution formation. The anticipated crystal structure for the three samples is BCC structure according to the valence electron concentration (VEC) theory, where the VEC values were less than 6.87 as suggested by Gou et. Al [7]. The RexNbMoTaW HEAs thin films are fabricated using RF magnetron sputtering. The film thickness, deposition power, and temperature impact on the films’ characteristics are studied. Field emission (FE-SEM), X-ray diffraction (XRD), and nanoindentation are used to investigate the RexNbMoTaW thin films’ crystal structure, surface morphology, and mechanical properties. The mechanical properties of the thin films will be compared with their counterpart bulk materials. References Kim, H., et al., International Journal of Refractory Metals and Hard Materials, 2019. 80: p. 286-291. Feng, X., et al., Materials Letters, 2018. 210: p. 84-87. Senkov, O.N., et al., Intermetallics, 2011. 19(5): p. 698-706. Han, Z.D., et al., Materials Science and Engineering: A, 2018. 712: p. 380-385. Zhang, J., et al., Journal of Alloys and Compounds, 2020. 827. Yang, X. and Y. Zhang, Materials Chemistry and Physics, 2012. 132(2-3): p. 233-238. Guo, S., et al., Journal of Applied Physics, 2011. 109(10): p. 103505. Figure 1
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Caradant, Lea, Nina Verdier, Gabrielle Foran, David Lepage, Arnaud Prébé, David Aymé-Perrot, and Mickaël Dollé. "The Influence of Polar Functional Groups in Hot-Melt Extruded Polymer Blend Electrolytes for Solid-State Lithium Batteries." ECS Meeting Abstracts MA2022-01, no. 2 (July 7, 2022): 210. http://dx.doi.org/10.1149/ma2022-012210mtgabs.
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Following the COP26 Summit in November 2021, more than hundred countries pledged to reach zero-emission by 2070 at the latest and the major car manufacturers committed to selling only electric vehicles by 2040. Currently, lithium-ion batteries (LIBs) are among the most widely used storage systems because of their high energy and power densities and long lifespan.1 The early LIBs are composed of intercalation electrodes, electronically isolated by an ion-conducting organic liquid electrolyte. However, the use of liquid electrolytes presents some disadvantages – especially in regard to consumer safety – related to short-circuits and potential leakages of the flammable liquid solvent. Moreover, in the case of lithium metal batteries, the combination of a liquid electrolyte and a high-capacity lithium metal anode leads to the uncontrolled deposition of lithium during the reduction, forming dendrites between the electrodes. A promising way to avoid this instability and improve battery safety is to replace the liquid electrolyte with an ion-conducting solid electrolyte.2 Among them, solid polymer electrolytes (SPEs) represent one of the most attractive alternatives due to their capacity to effectively conduct ions and higher mechanical resistance than their liquid counterparts.3 An important criterion for selecting polymers for use in SPEs is their ability to dissolve lithium salts through polar functional groups. Salt dissolution results in the replacement of ion-ion interactions in the lithium salt, with ion-dipole interactions in the polymer. The transport mechanisms of these ion-conducting materials differ from those of liquid electrolytes. Cation transport in polymer involves two steps which are considered to be dissociated or not, depending on the model chosen (Arrhenius or Vogel-Fulcher-Tammann, respectively). The application of one of these models provides interesting information on the ionic mobility dynamics in SPEs and, in particular, on the interplay between ionic jumps and polymer chain mobility. In the Arrhenius model, ionic jumps occur between coordinating sites, without taking into account the influence of segmental relaxation. Conversely, the VTF equation implies a strong relationship between these parameters. According to previous studies, higher segmental motions in the amorphous phase of polymers mainly provide ionic transport, which explains the limited ionic conductivity of SPEs at ambient temperature (less than 10-5 S/cm). Another major limitation of SPEs is primarily related to their dual role as electrolyte and binder in composite electrodes, which requires contradictory requirements to be met. Indeed, SPEs must have both sufficient flexibility to allow good interfacial contact between the electrode components and sufficient rigidity to limit short circuits. Polymer blending has emerged as an economic and effective technique to develop new SPEs which may simultaneously combine properties of each polymer and control the intrinsic properties of the resulting blend by adjusting the formulation.4 Moreover, polymer blends can be obtained by a solvent-free processing method, which reduce SPE toxicity and production time (no solvent evaporation). However, polymer blending makes both the salt dissociation processes and the ionic transport more difficult to understand as both polymers can dissolve lithium salts with their polar functional groups. Each polymer has different ionic transport properties depending on its architecture and thermal properties. Currently, no systematic survey comparing the ability of polymers with various functional groups to dissolve lithium salts in blends has thus far been conducted. In this presentation, we will discuss the salt dissociation ability of polar functional groups in various polymer blend SPEs. These groups are limited to those that are most commonly present in SPEs : ether, nitrile, carbonate, ester, alcohol and amide.5 The blends presented have been obtained by extrusion, which allows the effect of solvents on salt/polymer interactions to be neglected. In this work, coupled FTIR, EDX and 7Li NMR analyses allow the interactions between LiTFSI and the polymer blends to be determined with a good degree of certainty. Our original study combines experimental and theoretical approaches to determine effects of polymers’ lithium salt solvating ability on polymer blend electrolyte properties and represents an advancement in understanding and optimizing polymer selection for SPEs, used in lithium-ion batteries. References Xie, W., Liu, X., He, R., Li, Y., Gao, X., Li, X., Peng, Z., Feng, S., Feng, X. and Yang, S. Journal of Energy Storage 2020, 32, 101837. Chen, R., Qu, W., Guo, X., Li, L. and Wu, F. Materials Horizons 2016, 3, 487-516. Gray, F. M. Solid polymer electrolytes, VCH New Tork 1991. Caradant, L., Lepage, D., Nicolle, P., Prébé, A., Aymé-Perrot, D. and Dollé, M. ACS Applied Polymer Materials 2020, 4943-4951. Caradant, L., Verdier, N., Foran, G., Lepage, D., Prébé, A., Aymé-Perrot, D. and Dollé, M. ACS Applied Polymer Materials 2021. Figure 1
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Caradant, Lea, Nina Verdier, Gabrielle Foran, David Lepage, Arnaud Prébé, David Aymé-Perrot, and Mickaël Dollé. "The Influence of Polar Functional Groups in Melt-Blended Polymers Used As New Solid Electrolytes for Lithium Batteries." ECS Meeting Abstracts MA2022-02, no. 7 (October 9, 2022): 2423. http://dx.doi.org/10.1149/ma2022-0272423mtgabs.
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Following the COP26 Summit in November 2021, more than hundred countries pledged to reach zero-emission by 2070 at the latest and the major car manufacturers committed to selling only electric vehicles by 2040. Currently, lithium-ion batteries (LIBs) are among the most widely used storage systems because of their high energy and power densities and long lifespan.1 The early LIBs are composed of intercalation electrodes, electronically isolated by an ion-conducting organic liquid electrolyte. However, the use of liquid electrolytes presents some disadvantages – especially in regard to consumer safety – related to short-circuits and potential leakages of the flammable liquid solvent. Moreover, in the case of lithium metal batteries, the combination of a liquid electrolyte and a high-capacity lithium metal anode leads to the uncontrolled deposition of lithium during the reduction, forming dendrites between the electrodes. A promising way to avoid this instability and improve battery safety is to replace the liquid electrolyte with an ion-conducting solid electrolyte.2 Among them, solid polymer electrolytes (SPEs) represent one of the most attractive alternatives due to their capacity to effectively conduct ions and higher mechanical resistance than their liquid counterparts.3 An important criterion for selecting polymers for use in SPEs is their ability to dissolve lithium salts through polar functional groups. Salt dissolution results in the replacement of ion-ion interactions in the lithium salt, with ion-dipole interactions in the polymer. The transport mechanisms of these ion-conducting materials differ from those of liquid electrolytes. Cation transport in polymer involves two steps which are considered to be dissociated or not, depending on the model chosen (Arrhenius or Vogel-Tamman-Fulcher, respectively). The application of one of these models provides interesting information on the ionic mobility dynamics in SPEs and, in particular, on the interplay between ionic jumps and polymer chain mobility. According to previous studies, higher segmental motions in the amorphous phase of polymers mainly provide ionic transport, which explains the limited ionic conductivity of SPEs at ambient temperature (less than 10-5 S/cm). Another major limitation of SPEs is primarily related to their dual role as electrolyte and binder in composite electrodes, which requires contradictory requirements to be met. Indeed, SPEs must have both sufficient flexibility to allow good interfacial contact between the electrode components and sufficient rigidity to limit short circuits. Polymer blending has emerged as an economic and effective technique to develop new SPEs which may simultaneously combine properties of each polymer and control the intrinsic properties of the resulting blend by adjusting the formulation.4 Moreover, polymer blends can be obtained by a solvent-free processing method, which reduce SPE toxicity and production time and cost. However, polymer blending makes both the salt dissociation processes and the ionic transport more difficult to understand as both polymers can dissolve lithium salts with their polar groups. Each polymer has different ionic transport properties depending on its architecture and thermal properties. Currently, no systematic survey comparing the ability of polymers with various functional groups to dissolve lithium salts in blends has thus far been conducted. In this presentation, we will discuss the salt dissociation ability of polar functional groups in various polymer blend SPEs. These groups are limited to those that are most commonly present in SPEs : ether, nitrile, carbonate, ester, alcohol and amide.5 The blends presented have been obtained by extrusion, which allows the effect of solvents on salt/polymer interactions to be neglected. Coupled FTIR, EDX and 7Li NMR analyses allow the interactions between LiTFSI and the polymer blends to be determined with a good degree of certainty. Our original study combines experimental and theoretical approaches to determine effects of polymers’ lithium salt solvating ability on blend electrolyte properties. Finally, this survey highlights an ideal polymer couple with the most promising and complementary properties, usable as SPE for LIBs. Indeed, this blend presents encouraging properties, compared to single-polymer SPEs, such as higher ionic conductivities over a wide temperature range, as well as improved mechanical and thermal stability properties and cycling performances. References Xie, W., Liu, X., He, R., Li, Y., Gao, X., Li, X., Peng, Z., Feng, S., Feng, X. and Yang, S. Journal of Energy Storage 2020, 32, 101837. Chen, R., Qu, W., Guo, X., Li, L. and Wu, F. Materials Horizons 2016, 3, 487-516. Gray, F. M. Solid polymer electrolytes, VCH New Tork 1991. Caradant, L., Lepage, D., Nicolle, P., Prébé, A., Aymé-Perrot, D. and Dollé, M. ACS Applied Polymer Materials 2020, 4943-4951. Caradant, L., Verdier, N., Foran, G., Lepage, D., Prébé, A., Aymé-Perrot, D. and Dollé, M. ACS Applied Polymer Materials 2021. Figure 1
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Wijaya, Angeline, Timoticin Kwanda, and Jani Rahardjo. "PENERAPAN PRINSIP FENG SHUI PADA KAPLING DAN BANGUNAN RUMAH DI PERUMAHAN SURABAYA." Dimensi Utama Teknik Sipil 5, no. 1 (February 1, 2018): 8–13. http://dx.doi.org/10.9744/duts.5.1.8-13.
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Feng shui adalah sebuah ilmu yang mempelajari bagaimana cara manusia untuk hidup selaras dengan alam dan lingkungan sekitar. Prinsip feng shui pada dasarnya sederhana, karena mengikuti pola yin yang atau keseimbangan. Sehingga dengan penerapan nilai-nilai feng shui yang baik pada rumah tinggal, maka akan memberikan kenyamanan bagi penghuni rumah dan memberikan nilai serta harga jual yang lebih tinggi. Perumusan masalah dari penelitian ini adalah untuk mengetahui seberapa dalam faktor feng shui yang dipertimbangkan oleh penghuni. Kemudian mencari adanya hubungan antara unsur feng shui yang dipercaya dengan penerapan terhadap penyelesaian masalah feng shui secara desain dan non-desain. Chi square digunakan untuk melihat apakah ada hubungan antara prinsip feng shui dengan aplikasinya. Hasil yang ditemukan menunjukkan bahwa faktor feng shui yang paling dipertimbangkan oleh penghuni rumah tinggal yang bermasalah menurut prinsip feng shui adalah faktor denah rumah. Dan didapatkan hasil yang menyatakan bahwa adanya hubungan antara kepercayaan terhadap faktor feng shui dengan penerapan pada faktor bentuk kapling, faktor benda di sekitar bangunan, faktor posisi rumah terhadap jalan, faktor bentuk bangunan, faktor denah rumah, dan faktor nomor rumah, cermin feng shui dan ba gua.
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Zhang, J., X. Guo, Q. Bu, X. Shen, and Z. Feng. "AB0082 ANTI-INFLAMMATORY EFFECTS OF TOTAL SAPONINS OF PANAX JAPONICUS ON RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1173.1–1173. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3460.
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BackgroundRheumatoid arthritis (RA) is a common autoimmune disease with inflammation[1]. Total saponins of Panax japonicus (TSPJs) are effective components extracted from Panax japonicus[2]. They are known to exhibit anti-inflammatory and immunosuppressoive properties, but their effect of anti-inflammation in collagen-induced arthritis (CIA) remains unclear.ObjectivesTo investigate the anti-inflammatory targets of TSPJ predicted by bioinformatics and the verification in CIA mice.MethodsThe targets of RA are obtained in the GeneCards database. we used Cytoscape 3.7.2 software to construct a protein-protein interactions (PPI) network and obtain the hub genes. There are four effective components of TSPJ: Araloside A, chikusetsusaponin IVa, ginsenoside Rg2, and ginsenoside Ro. Through molecular docking between the screened hub genes and the four effective components of TSPJ, the possibility of TSPJ treating CIA mice can be predicted. The collagen II (CII) and complete Freund’s adjuvant (CFA) were used to induce the CIA model. After establishing the model, 32 DBA1/J mice were divided into C group (n=8), M group (n=8), L group(n=8), and H group(n=8). The L and H groups were gavaged with TSPJ at 30 mg/kg or 150 mg/kg, and the C and M groups were gavaged with normal saline. The thickness of the hind paw, number of swollen joints, and arthritis index were evaluated. After 11 days of treatment, all the mice were sacrificed after anesthesia. Sera were collected to centrifuge tubes and the levels of inflammatory factor were determined by the ELISA kit following the instruction.ResultsA gene list that enriches 263 genes was obtained by searching RA from the GeneCards database. The hub genes of the top 3 obtained from Cytoscape 3.7.2 software were tumor necrosis factor (TNF), interleukin-1β (IL-1β), and interleukin-6 (IL-6). In addition, interleukin-17A (IL-17A), a classical inflammatory index in the top 10, was selected and included in the predicted target. The results of molecular docking between the predicted target and the components of TSPJ showed that the combined pose has good stability. The numerical value of hind paw thickness, swollen joint counts, and arthritis index in the intervention groups were lower than those in the M group, suggesting TSPJ played a critical role in improving pathological changes. Compared to those of the C group, the serum levels of TNF-α, IL-1β, IL-6, and IL-17A were increased in the M group. Compared to those of the M group, the levels of TNF-α, IL-1β, IL-6, and IL-17A in the L and H groups were decreased. Compared to those of the L group, the levels of TNF-α, IL-1β, IL-6, and IL-17A in the H group were decreased. The results suggested that TSPJ may decrease the levels of TNF-α, IL-1β, IL-6, and IL-17A in CIA mice. These results suggest that TSPJ may inhibit the inflammatory effects of CIA mice.ConclusionCurrent study demonstrated a novel inhibitory effect of TSPJ on inflammation in CIA mice, and TSPJ can act on the targets predicted by bioinformatics of CIA mice, suggesting the potential of TSPJ as a therapeutic agent for RA and providing new ideas for the clinical treatment of RA.References[1]Scherer HU, Haupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun[J]. 2020;110:102400[2]Guo X, Ji J, Jose Kumar Sreena GS, et al. Computational Prediction of Antiangiogenesis Synergistic Mechanisms of Total Saponins of Panax japonicus Against Rheumatoid Arthritis. Front Pharmacol[J]. 2020;11:566129AcknowledgementsJingkai Zhang: Preparation, data presentation, and specifically writing the initial draft. Xiang Guo: Application of statistical, Verification. Qinpeng Bu and Xiaolan Shen: Conducting a research and investigation process, Provision of study materials. Zhitao Feng: Ideas, Design of methodology, and including mentorship external to the core team.Disclosure of InterestsNone declared
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Qiu, M. T., S. X. Zhang, J. Cao, J. Q. Zhang, J. Qiao, R. Zhao, M. J. Chang, et al. "AB0587 IMMUNOMODULATORY COMBINATION THERAPIES IN PATIENTS WITH DERMATOMYOSITIS /POLYMYOSITIS: A RETROSPECTIVE CROSS-SECTIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1590.1–1590. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2478.
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Background:Dermatomyositis (DM)/Polymyositis(PM) is an autoimmune disease that typically involve the striated muscle with a variable involvement of the skin and other organs1. Lymphocyte subsets disorders may contribute to the pathogenesis of DM/PM. It has been discovered that immunomodulatory drugs such as low-dose interleukin (IL)−2, rapamycin can help to regulate the lymphocyte subsets and control the disease and improve the prognosis2-4.Objectives:To investigate the levels of peripheral lymphocyte and CD4+T subsets of DM/PM patients and further to observe the regulatory effect of modulatory therapy on these cells in PM/DM at a relative large-sample size.Methods:Total 450 patients with PM/DM and 206 healthy controls (HCs) were enrolled in this study. Among these participations, 320 patients received immunomodulatory combination therapies (immunomodulatory drugs include low-dose interleukin-2, rapamycin, metformin, retinoic acid etc). The absolute numbers of T, B, NK, CD4+T, CD8+T, Th1, Th2, Th17 and Tregs in peripheral blood of these individuals were detected by flow cytometry combined with standard absolute counting beads before and after the treatment.Results:Patients with DM/PM had lower levels of total T, CD4+T, CD8+T, Th2, Th17, NK, Th1 and Tregs compared with those of HCs (P < 0.05). After immunomodulatory combination treatments, there was a dramatically increases various peripheral lymphocyte subsets such as T, B, CD4+T, CD8+T, NK, Th1, Th17 and Tregs (P < 0.05). Moreover, the increase in Tregs was much more than that in effector T cells (Teffs), resulting a rebalance of immune systems.Conclusion:The unbalance of lymphocyte cells should contribute to the pathogenesis of DM/PM patients. Immunomodulatory combination therapies could promote the proliferation and functional recovery of Tregs in patients and might help to alleviate disease activity.References:[1]Herbelet S, De Bleecker JL. Immune checkpoint failures in inflammatory myopathies: An overview. Autoimmunity reviews 2018;17(8):746-54. doi: 10.1016/j.autrev.2018.01.026 [published Online First: 2018/06/10][2]Feng M, Guo H, Zhang C, et al. Absolute reduction of regulatory T cells and regulatory effect of short-term and low-dose IL-2 in polymyositis or dermatomyositis. International immunopharmacology 2019;77:105912. doi: 10.1016/j.intimp.2019.105912 [published Online First: 2019/11/02][3]Zhang SX, Wang J, Sun HH, et al. Circulating regulatory T cells were absolutely decreased in dermatomyositis/polymyositis patients and restored by low-dose IL-2. Annals of the rheumatic diseases 2019 doi: 10.1136/annrheumdis-2019-216246 [published Online First: 2019/10/16][4]Zhao C, Chu Y, Liang Z, et al. Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients. BMC immunology 2019;20(1):32. doi: 10.1186/s12865-019-0305-0 [published Online First: 2019/09/06]Acknowledgments:NoneDisclosure of Interests:None declared
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Fu, T., Y. Yang, X. Gu, C. Dong, R. Zhao, J. Ji, Z. Xue, X. Zhang, and Z. Gu. "POS0761 INVESTIGATION ON THE EFFECT AND MECHANISM OF ABNORMALLY ACTIVATED CD8+ T CELLS FROM BONE MARROW ON HEMATOPOIETIC STEM CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 634.1–634. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3060.
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Background:SLE is an autoimmune disease characterized by the abnormal function of lymphocytes. The impairment of hematopoietic function of bone marrow participates in its pathogenesis, in which T cells play an important role. However, study on bone marrow T cells in SLE patients is very limited.Objectives:This study aims to characterize the phenotype and molecular characteristics of abnormally activated CD8+T cells in bone marrow of SLE patients and explore the mechanism of hematopoietic stem cells (HSCs) reduction caused by the abnormally activated CD8+T cells in bone marrow of patients with SLE.Methods:A total of 8 SLE patients and 5 age- and sex-matched controls were recruited in our study. Among them, 3 SLE patients and 4 donors were collected bone marrow and peripheral blood samples for Single-cell RNA sequencing (scRNA-seq) and functional studies. BM and peripheral T cell subsets were measured by flow cytometry. Plasma cytokines and secreted immunoglobulins were detected by Luminex. Disease activity of SLE patients was measured using the SLE Disease Activity Index (SLEDAI). All analyses were performed using R language and Flowjo 9.Results:In the present study, SLE patients had increased CD8+T%αβT cells and decreased CD4+T%αβT cells in bone marrow of SLE, compared to healthy controls. A large number of CD38+HLADR+CD8+T cells existed in the bone marrow and peripheral blood of SLE patients. Those patients also showed reduced number of HSCs, and with a downward trend of the numbers of peripheral red blood cells, white blood cells, neutrophils, hemoglobin, and platelets. By scRNA-seq, the CD38+HLADR+CD8+T cells contained high levels of GZMK, GZMA, PRF1, IFNG, and TNF in the bone marrow of SLE patients. the CD38+HLADR+CD8+T cells exhibited significant relationship with HSCs, white blood cells, neutrophils, and platelets.Conclusion:These findings demonstrated that the abnormally activated CD8+T cells in bone marrow can reduce the number of HSCs by the expression of killer molecules, which contributes to the impairment of hematopoietic function and the development of SLE. This project focuses on the specific bone marrow T cell subset in SLE. The completement of this project provides information for exploring the mechanism of hematopoiesis involvement.References:[1]Anderson E, Shah B, Davidson A, Furie R. Lessons learned from bone marrow failure in systemic lupus erythematosus: Case reports and review of the literature. Semin Arthritis Rheum. 2018;48(1):90-104.[2]Sun LY, Zhou KX, Feng XB, Zhang HY, Ding XQ, Jin O, Lu LW, Lau CS, Hou YY, Fan LM. Abnormal surface markers expression on bone marrow CD34+cells and correlation with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol. 2007;26(12):2073-2079.Acknowledgements:We want to thank Lu Meng, Teng Li, Wei Zhou, and Jiaxin Guo for their assistance with this study.Disclosure of Interests:None declared
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Li, Yunyun, Jianxia Chang, Yimin Wang, Aijun Guo, Lifeng Luo, Feng Ma, and Jingjing Fan. "Corrigendum: Hydrology Research 50 (1), 244–261: Spatiotemporal impacts of land use land cover changes on hydrology from the mechanism perspective using SWAT model with time-varying parameters, Yunyun Li, Jianxia Chang, Lifeng Luo, Yimin Wang, Aijun Guo, Feng Ma and Jingjing Fan, doi: 10.2166/nh.2018.006." Hydrology Research 50, no. 3 (April 5, 2019): 990. http://dx.doi.org/10.2166/nh.2019.000.
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Szkopek, Thomas, Kaiwen Hu, William Cardenas, Yi-Chi Huang, Huijing Wei, Robert-Eric Gaskell, Eli Martel, and Marta Cerruti. "(Invited) Graphene Oxide-Based Membranes: Viscoelastic Properties and Application to Broadband Microspeakers." ECS Meeting Abstracts MA2022-01, no. 12 (July 7, 2022): 850. http://dx.doi.org/10.1149/ma2022-0112850mtgabs.
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Graphene and graphene derivatives have attracted attention as materials for acoustic transduction [1-3]. Graphene oxide (GO) membranes and borate cross-linked graphene oxide (X-GO) membranes combine high stiffness, low mass density, and high loss coefficient. We show [4] that these mechanical properties are ideal for efficient, broadband, electro-acoustic transduction, where the acoustic diaphragm should be light, stiff, and internally damped. We present a quantitative comparison of the figure of merit, (E/ρ 3)1/2, where E is Young's modulus and ρ is the mass density, and the material performance index, tan δ (E/ρ 3)1/2, where tan δ is the loss coefficient. GO and X-GO exhibit high figures of merit, comparable to that of wood and exceeding that of aluminum and thermoplastics. The material performance indices of GO and X-GO exceed that of wood, thermoplastics, and aluminum. The latter are common diaphragm materials in acoustic transducers. For acoustic applications, it is important to understand the frequency dependent viscoelastic response. The complex modulus G = G' + iG'' of GO and X-GO membranes was measured by dynamic mechanical analysis and analyzed by the application of the time-temperature superposition (TTS) principle of polymer rheology. We find that X-GO shows a more than 30% increase in storage modulus G’ over the frequency range of 1 to 10 kHz, exceeding 55 GPa at 10 kHz. There is a reduction in loss coefficient tan δ = G''/G' for X-GO of ≈30% over the same frequency range, reaching tan δ = 0.04 at 10 kHz, which is approximately one order of magnitude larger than that of aluminum. A quantitative comparison of microspeaker performance was conducted at a fixed diaphragm mass m = 15-20 g and 14 mm x 8 mm size, including GO, X-GO, oak wood, polyethylene terephthalate (PET), aluminum, and titanium. Scanning laser measurements confirm pistonic operation of X-GO membranes. Microspeaker sound pressure level response was measured in both time and frequency domains. X-GO diaphragms exhibit 45% higher damping than aluminum membranes in microspeaker assemblies. Consequently, X-GO membranes enable the upshift of loudspeaker breakup frequency by 1/6 to 1/2 octave above speakers assembled with oak wood, PET, aluminum and titanium membranes. GO based materials are thus found to be an exceptional material for electro-acoustic transduction. References: [1] Q. Zhou, A. Zettl, Appl. Phys. Lett. 102, 223109 (2013). [2] A. U. Khan, G. Zeltzer, G. Speyer, Z. K. Croft, Y. Guo, H. Nagar, V. Artel, A. Levi, C. Stern, D. Naveh, G. Liu, Adv. Mat. 33, 2004053 (2021). [3] H. Tian, T.-L. Ren, D. Xie, Y.-F. Wang, C.-J. Zhou, T.-T. Feng, D. Fu, Y. Yang, P.-G. Peng, L.-G. Wang, L.-T. Liu, ACS Nano 5, 4878 (2011). [4] K. Hu, R.E.Gaskell, W. Cardenas, H. Wei, Y.-C. Huang, M. Cerruti, T. Szkopek, Adv. Func. Mat. 2107167 (2021). Figure 1
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Yang, Xin, Gao-xiang Wang, and Jian-feng Zhou. "Erratum to: CAR T Cell Therapy for Hematological Malignancies." Current Medical Science 41, no. 1 (February 2021): 187. http://dx.doi.org/10.1007/s11596-020-2280-3.
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The article “CAR T Cell Therapy for Hematological Malignancies”, written by Xin YANG, Gao-xiang WANG, Jian-feng ZHOU, was originally published electronically on the publisher’s internet portal on December 2019 without open access.
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Dubey, Siddharth, Vivek Trikha, Arvind Kumar, and Samarth Mittal. "Commentaires sur: “Cementless distal fixation modular stem without reconstruction of femoral calcar for unstable intertrochanteric fracture in patients aged 75 years or more” de G.C. Zha, J. Liu, Y. Wang, S. Feng, X.Y. Chen, K.J. Guo, J.Y. Sun publiés dans Orthop Traumatol Surg Res. 2019;105(1):35-39." Revue de Chirurgie Orthopédique et Traumatologique 105, no. 4 (June 2019): 539–40. http://dx.doi.org/10.1016/j.rcot.2019.04.021.
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Dubey, Siddharth, Vivek Tirkha, Arvind Kumar, and Samarth Mittal. "Comments on “Cementless distal fixation modular stem without reconstruction of femoral calcar for unstable intertrochanteric fracture in patients aged 75 years or more” of Zha GC, Liu J, Wang Y, Feng S, Chen XY, Guo KJ, Sun JY. Published in Orthop Traumatol Surg Res. 2019;105(1):35–39." Orthopaedics & Traumatology: Surgery & Research 105, no. 4 (June 2019): 795. http://dx.doi.org/10.1016/j.otsr.2019.04.004.
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Matysiak, Wiktor, Tomasz Tański, and Weronika Monika Smok. "Morphology and structure characterization of crystalline SnO2 1D nanostructures." Photonics Letters of Poland 12, no. 3 (September 30, 2020): 70. http://dx.doi.org/10.4302/plp.v12i3.1019.
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In recent years, many attempts have been made to improve the sensory properties of SnO2, including design of sensors based on one-dimensional nanostructures of this material, such as nanofibers, nanotubes or nanowires. One of the simpler methods of producing one-dimensional tin oxide nanomaterials is to combine the electrospinning method with a sol-gel process. The purpose of this work was to produce SnO2 nanowires using a hybrid electrospinning method combined with a heat treatment process at the temperature of 600 °C and to analyze the morphology and structure of the one-dimensional nanomaterial produced in this way. Analysis of the morphology of composite one-dimensional tin oxide nanostructures showed that smooth, homogeneous and crystalline nanowires were obtained. Full Text: PDF ReferencesN. Dharmaraj, C.H. Kim, K.W. Kim, H.Y. Kim, E.K. Suh, "Spectral studies of SnO2 nanofibres prepared by electrospinning method", Spectrochim. Acta - Part A Mol. Biomol. Spectrosc. 64, (2006) CrossRef N. Gao, H.Y. Li, W. Zhang, Y. Zhang, Y. Zeng, H. Zhixiang, ... & H. Liu, "QCM-based humidity sensor and sensing properties employing colloidal SnO2 nanowires", Sens. Actuators B Chem. 293, (2019), 129-135. CrossRef W. Ge, Y. Chang, V. Natarajan, Z. Feng, J. Zhan, X. Ma, "In2O3-SnO2 hybrid porous nanostructures delivering enhanced formaldehyde sensing performance", J.Alloys and Comp. 746, (2018) CrossRef M. Zhang, Y. Zhen, F. Sun, C. Xu, "Hydrothermally synthesized SnO2-graphene composites for H2 sensing at low operating temperature", Mater. Sci. Eng. B. 209, (2016), 37-44. CrossRef Y. Zhang, X. He, J. Li, Z. Miao, F. Huang, "Fabrication and ethanol-sensing properties of micro gas sensor based on electrospun SnO2 nanofibers", Sens. Actuators B Chem. 132, (2008), 67-73. CrossRef W.Q. Li, S.Y. Ma, J. Luo, Y.Z. Mao, L. Cheng, D.J. Gengzang, X.L. Xu, S H. Yan, "Synthesis of hollow SnO2 nanobelts and their application in acetone sensor", Mater. Lett. 132, (2014), 338-341. CrossRef E. Mudra, I. Shepa, O. Milkovic, Z. Dankova, A. Kovalcikova, A. Annusova, E. Majkova, J. Dusza, "Effect of iron doping on the properties of SnO2 nano/microfibers", Appl. Surf. Sci. 480, (2019), 876-881. CrossRef P. Mohanapriya, H. Segawa, K. Watanabe, K. Watanabe, S. Samitsu, T.S. Natarajan, N.V. Jaya, N. Ohashi, "Enhanced ethanol-gas sensing performance of Ce-doped SnO2 hollow nanofibers prepared by electrospinning", Sens. Actuators B Chem. 188, (2013), 872-878. CrossRef W.Q. Li, S.Y. Ma, Y.F. Li, X.B. Li, C.Y. Wang, X.H. Yang, L. Cheng, Y.Z. Mao, J. Luo, D.J. Gengzang, G.X. Wan, X.L. Xu, "Preparation of Pr-doped SnO2 hollow nanofibers by electrospinning method and their gas sensing properties", J.Alloys and Comp. 605, (2014), 80-88. CrossRef X.H. Xu, S.Y. Ma, X.L. Xu, T. Han, S.T. Pei, Y. Tie, P.F. Cao, W.W. Liu, B.J. Wang, R. Zhang, J.L. Zhang, "Ultra-sensitive glycol sensing performance with rapid-recovery based on heterostructured ZnO-SnO2 hollow nanotube", Mater. Lett, 273, (2020), 127967. CrossRef F. Li, X. Gao, R. Wang, T. Zhang, G. Lu, Sens. "Study on TiO2-SnO2 core-shell heterostructure nanofibers with different work function and its application in gas sensor", Actuators B Chem, 248, (2017), 812-819. CrossRef S. Bai, W. Guo, J. Sun, J. Li, Y. Tian, A. Chen, R. Luo, D. Li, "Synthesis of SnO2–CuO heterojunction using electrospinning and application in detecting of CO", Sens Actuators B Chem, 226, (2016), 96-103. CrossRef H. Du, P.J. Yao, Y. Sun, J. Wang, H. Wang, N. Yu, "Electrospinning Hetero-Nanofibers In2O3/SnO2 of Homotype Heterojunction with High Gas Sensing Activity", Sensors, 17, (2017), 1822. CrossRef X. Wang, H. Fan, P. Ren, "Electrospinning derived hollow SnO2 microtubes with highly photocatalytic property", Catal. Commun. 31, (2013), 37-41. CrossRef L. Cheng, S.Y. Ma, T.T. Wang, X.B. Li, J. Luo, W.Q. Li, Y.Z. Mao, D.J Gengzang, "Synthesis and characterization of SnO2 hollow nanofibers by electrospinning for ethanol sensing properties", Mater. Lett. 131, (2014), 23-26. CrossRef P.H. Phuoc, C.M. Hung, N.V. Toan, N.V. Duy, N.D. Hoa, N.V. Hieu, "One-step fabrication of SnO2 porous nanofiber gas sensors for sub-ppm H2S detection", Sens. Actuators A Phys. 303, (2020), 111722. CrossRef A.E. Deniz, H.A. Vural, B. Ortac, T. Uyar, "Gold nanoparticle/polymer nanofibrous composites by laser ablation and electrospinning", Matter. Lett. 65, (2011), 2941-2943. CrossRef S. Sagadevan, J. Podder, "Investigation on Structural, Surface Morphological and Dielectric Properties of Zn-doped SnO2 Nanoparticles", Mater. Res. 19, (2016), 420-425. CrossRef
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Wang, Zhen-xin, Xi-long Feng, Chengwei Liu, Jin-ming Gao, and Jianzhao Qi. "Correction: Wang et al. Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus. Antibiotics 2022, 11, 1097." Antibiotics 11, no. 11 (November 21, 2022): 1671. http://dx.doi.org/10.3390/antibiotics11111671.
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In the original publication, there were publisher errors in the names of authors Zhen-xin Wang, Xi-long Feng and Jin-ming Gao and affiliation (1) of the first, second, fourth and fifth authors (name of the Key Laboratory and city) [...]
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Ark, R., and M. Bukhari. "POS0511 USING HIP STRUCTURAL ANALYSIS MEASUREMENTS TO PREDICT FRACTURE IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 488.2–489. http://dx.doi.org/10.1136/annrheumdis-2021-eular.802.
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Background:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease and increases the risk of developing osteoporosis. Incidence of fracture is higher in this group of patients compared to the general population and can lead to increased morbidity (1). Bone strength of the proximal femur is not only linked to bone mineral density; it also depends on the geometric properties of the bone mass (2). Hip structural analysis (HSA) is a technique used to assess hip bone structure that takes geometric measurements of the femur from dual-energy X-ray absorptiometry (DEXA) images (3).Objectives:To determine whether HSA measurements help predict fracture in patients with RA.Methods:Data were collected from June 2004 to August 2017 from RA patients who underwent a DEXA scan at a District General Hospital. This included hip axis length (HAL), cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), distance from centre of femoral head to centre of femoral neck (D1) and to inter-trochanteric line (D2), mean femoral neck diameter (D3), shaft angle (A) neck/shaft angle (Θ) and proximal femur strength index (SI) and distance from centre of mass of femoral neck to superior neck margin (Y). Fracture was predicted by a series of binomial logistic regression models, adjusted for sex, age and bone mineral density (BMD). Odds ratios with 95% confidence intervals and area under the receiver operating characteristic curve (AUC) were calculated.Results:2077 patients with RA were identified, 1632 were female and the mean age was 66.7. HAL, D1, D2, D3, A, Θ and Y were not significant predictors of fracture in regression models; odds ratios are included in table 1. CSA, CSMI and SI predicted fracture risk. The AUC for CSA, CSMI and SI regression models were 0.632, 0.609 and 0.625 respectively.Table 1.Odds ratios of fracture for different HSA parameters in RA patientsHSA ParameterOdds Ratio (95% Confidence Interval)HAL1.01410 (0.99958 - 1.02883)CSMI0.99994 (0.99990 - 0.99998)CSA0.98523 (0.98065 - 0.98982)D11.01683 (0.98925 - 1.04518)D21.01286 (0.99886 - 1.02705)D31.00664 (0.96958 - 1.04511)Y1.04580 (0.98633 - 1.10886)A1.00898 (0.98878 - 1.02959)Θ1.00276 (0.98672 - 1.01906)SI0.56769 (0.43400 - 0.74258)Figure 1.Receiver operating characteristic curves for CSA (red), CSMI (green) and SI (blue). AUC for CSA was 0.632, CSMI-0.609 and SI-0.625.Conclusion:These data suggest that CSA, CSMI and SI help predict the fracture risk in patients with RA. HAL, D1, D2, D3, A, Θ and Y do not predict risk of fracture. The CSA regression model was the strongest predictor of fracture. HSA measurements can therefore help predict risk of fracture in conjunction with other factors. Limitations of the study are that it was retrospective and only studied patients who had a DEXA scan.References:[1]Xue A, Wu S, Jiang L, Feng A, Guo H, Zhao P. Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. Medicine. 2017; 96 (36): e6983. Available from: doi: 10.1097/MD.0000000000006983.[2]Faulkner KG, Wacker WK, Barden HS, Simonelli C, Burke PK, Ragi S, Del Rio L. Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int. 2006;17(4):593-9. doi: 10.1007/s00198-005-0019-4.[3]Kaptoge S, Beck TJ, Reeve J, Stone KL, Hillier TA, Cauley JA, et al. Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures. Journal of Bone and Mineral Research. 2008; 23 (12): 1892-1904. Available from: doi: https://doi.org/10.1359/jbmr.080802.Disclosure of Interests:None declared
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JIANG, KE, JIN-LONG REN, JUN-FENG GUO, ZENG WANG, LI DING, and JIA-TANG LI. "Erratum: KE JIANG, JIN-LONG REN, JUN-FENG GUO, ZENG WANG, LI DING1 & JIA-TANG LI (2020) A new species of the genus Dendrelaphis (Squamata: Colubridae) from Yunnan Province, China, with discussion of the occurrence of D. cyanochloris (Wall, 1921) in China. Zootaxa, 4743: 001–020." Zootaxa 4759, no. 4 (April 6, 2020): 600. http://dx.doi.org/10.11646/zootaxa.4759.4.13.
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Shen, X., L. Yanqun, X. Guo, W. Linfeng, J. Zhang, and Z. Feng. "AB0012 IDENTIFICATION OF NEW BIOMARKERS FOR SINOMENINE TREATMENT IN RHEUMATOID ARTHRITIS BASED ON BIOINFORMATICS ANALYSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1141.2–1141. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3555.
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BackgroundSinomenine (SIN) were extracted from Caulis Sinomenii and achieved an remarkable therapeutic effect for Rheumatoid Arthritis (RA). However, the mechanism of SIN acting on RA is not clear yet.ObjectivesTo excavate potential targets and mechanisms of SIN for RA through bioinformatics.MethodsThe microarray data were downloaded from the Gene Expression Omnibus (GEO) database. GEO2R was used to identify differentially expressed genes (DEGs) and the unique value was retained. The potential targets of active compounds from various databases were screened. Based on the overlapping genes, Cytoscape 3.7.2 software was used to construct a protein-protein interactions (PPI) network and to visualize the mechanisms of the treatment by Gene Ontology (GO) enrichment analysis Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis by DAVID database. Finally, we used AutoDockTools 1.5.6 for molecular docking.ResultsA total of 5053 DEGs and 1070 intersections were obtained, including 486 up-regulated and 584 down-regulated targets. 298 SIN targets were collected from various databases, 84 potential targets were obtained by intersecting with DEGs. There are 80 nodes and 305 edges were obtained in PPI network. Based on the degree, the top 10 target genes were AKT1, RGFR, MTOR, JAK2, NOS3, IL2, IL6, MMP9, MAPK8, HSP9OAA1. The core targets was most relevant to protein phosphorylation, signal transduction though GO analysis. The results of the KEGG enrichment analysis included PI3K-Akt signaling pathway and Neuroactive ligand-receptor interaction. Following analysis found that AKT1, EGFR, MTOR and JAK2 existed in the PI3K-Akt signaling pathway. Molecular docking was used to confirm that the binding energy of AKT1 was -7.68 kJ mol -1, EGFR was -5.33kJ mol-1, and MTOR was -4.77 kJ mol-1,JAK2 was -3.25 KJ mol-1. AKT1 and EGFR was further identified as the core targets.ConclusionPresent study show that AKT1 and EGFR may be the key targets of SIN acting on the PI3K-Akt signaling pathway, thereby inhibiting the progression of disease and improving RA.Keywords: Sinomenine; Rheumatoid Arthritis; bioinformatics;Disclosure of InterestsNone declaredFundingThis project was supported by grants from National Natural Science Foundation of China (No. 81703783 and 81503415);Identification of new biomarkers for Sinomenine treatment in Rheumatoid Arthritis based on bioinformatics analysisXL Shen1, 2L,YQ L1, 2Y,X Guo1, 2,LF Wang1, 2,JK Zhang1, 2,ZT Feng1, 2*1. Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges University, Yichang, Hubei 443002, China2. Medical College of China Three Gorges University, Yichang, Hubei 443002, China†These authors contributed equally to this work.*Authors to whom correspondence should be addressed:Correspondence: Zhitao FengE-mail: zhitao.feng@ctgu.edu.cn (Zhitao Feng)Disclosure of InterestsNone declared
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Liang, Y., H. Y. Wen, Y. Duan, Y. Liu, Z. Yu, W. Niu, and C. Gao. "AB0588 INFECTION AGGRAVATED DECREASE OF THE LEVEL OF TH17 AND TREG CELLS AND LOW-DOSE IL-2 REBALANCED TH17/TREG IN THE PERIPHERAL BLOOD OF PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1591.3–1591. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5255.
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Background:Idiopathic inflammatory myopathies (IIM) are featured by a series of clinical presentation such as proximal muscle weakness, increased serum levels of creatine kinase and other muscle enzymes and involvement of other organs and systems[1, 2], which results in high morbidity and early mortality[3]. We have known the changes of the level of Th17 and Treg cells in IIM in previous studies[4-6]. However, whether infection affects lymphocyte subsets or not and whether the effect of low-dose interleukin-2 (IL-2) can be influenced by the use of immunosuppressants or not are still unclear.Objectives:The study aimed to explore the changes of lymphocyte subsets in patients of IIM with or without important organ infection, and the restoration of Th17/Treg after receiving low-dose IL-2.Methods:A total of 118 IIM patients were enrolled and classified into infection group and non-infection group based on the important organ infection. Of them, 48 cases were treated with low dose IL-2 (5.0*105IU for 5 days). The absolute number of peripheral total T, B, CD4+T, CD8+T, NK, Th1, Th2, Th17 and Treg cell subsets were analyzed by flow cytometry combined with absolute counting beads. Clinical data, laboratory examinations and the levels of peripheral lymphocyte subsets were analyzed retrospectively.Results:In these patients, especially in the infection group, the absolute number of T, CD4+T, CD8+T, NK, Th1, Th2, Th17 and Treg cells were significantly decreased as compared with that in the healthy controls, which were significantly increased by low dose IL-2 (especially Treg cells) treatment. The levels of ESR, LDH and HBDH and the ratio of Th17/Treg were significantly lower than those before IL-2 treatment (Z=-2.237, -2.083, -2.140, -3.663,P=0.025, 0.037, 0.032, 0.000). The 48 cases who received IL-2 treatment were divided into 2 groups according to whether they used immunosuppressants. There was no significant difference in the absolute number of T, B, CD4+T, CD8+T, Th1, Th2, Th17 and Treg cells, the proportion of Th17 and Treg cells and the ratio of Th17/Treg between the 2 groups (P>0.05).Conclusion:Global decrease in lymphocyte subsets was found in IIM patients, especially those who had important organ infection. A significant re-balance of Th17/Treg was observed after receiving treatment with low-dose IL-2. Furthermore, the restoration of lymphocyte subsets showed similar degree after treatment with or without immunosuppressants. Low-dose IL-2 may become a potential therapy for IIM patients. The mechanism of lymphocyte decrease in IIM is required further to study.References:[1]Clark K E N, Isenberg D A. A review of inflammatory idiopathic myopathy focusing on polymyositis[J]. European Journal of Neurology, 2017.[2]Tieu J, Lundberg IE, Limaye V. Idiopathic inflammatory myositis. Best Pract Res Clin Rheumatol. 2016. 30(1): 149-68.[3]Mandel DE, Malemud CJ, Askari AD. Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis. Int J Mol Sci. 2017. 18(5).[4]Zhang SX, Wang J, Sun HH, et al. Circulating regulatory T cells were absolutely decreased in dermatomyositis/polymyositis patients and restored by low-dose IL-2. Ann Rheum Dis. 2019 .[5]Espinosa-Ortega F, Gómez-Martin D, Santana-De Anda K, Romo-Tena J, Villaseñor-Ovies P, Alcocer-Varela J. Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets. Clin Exp Immunol. 2015. 179(3): 520-8.[6]Feng M, Guo H, Zhang C, et al. Absolute reduction of regulatory T cells and regulatory effect of short-term and low-dose IL-2 in polymyositis or dermatomyositis. Int Immunopharmacol. 2019. 77: 105912.Acknowledgments:Thanks for the support of my teachers, classmates and my family.Disclosure of Interests:None declared
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Zhang, Yingying, Xin Liu, Liwen Liu, Jianan Chen, Qiuyue Hu, Shen Shen, Yongjian Zhou, et al. "Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma." Disease Markers 2020 (January 13, 2020): 1–17. http://dx.doi.org/10.1155/2020/2514090.
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Background. Studies show that patients with hepatocellular carcinoma (HCC) have poor prognosis, particularly when patients are diagnosed at late stages of the disease development. The flap endonuclease 1 (FEN1) gene is overexpressed in multiple malignant tumors and may promote tumor aggressiveness. However, its expression profile and functional roles in HCC are still unclear. Here, we evaluated the molecular mechanisms of FEN1 in HCC. Methods. The expression of FEN1 in HCC was evaluated using HCC mRNA expression data from TCGA and GEO databases. The expression of FEN1 was also confirmed by immunohistochemistry (IHC) using a tissue microarray (TMA) cohort with a total of 396 HCC patients. Kaplan-Meier analysis and univariate and multivariate Cox regression analyses were used to determine the correlation between FEN1 expression and survival rate of HCC patients. The molecular mechanism and biological functions of FEN1 in HCC were predicted using functional and pathway enrichment analysis in vitro experiments. Results. FEN1 was overexpressed in multiple HCC cohorts at both mRNA and protein levels. The receiver operating characteristic (ROC) curve showed that FEN1 can serve as a diagnostic predictor of HCC. Meanwhile, patients with high FEN1 expression levels showed lower overall survival (OS) and relapse-free survival (RFS) rates than those with low FEN1 expression. More importantly, we found that FEN1 elevation was an independent prognostic factor for OS and RFS in HCC patients based on univariate and multivariate analyses, indicating that FEN1 might be a potential prognostic marker in HCC. Furthermore, knocking down FEN1 resulted in suppressed cell proliferation and migration in vitro. This could have been due to regulation expressions of c-Myc, survivin, and cyclin D1 genes, indicating that FEN1 may function as an oncogene through its role in the cell cycle and DNA replication pathway. Conclusion. Our study indicated that high FEN1 expression might function as a biomarker for diagnosis and prognosis. In addition, the study confirms that FEN1 is an oncogene in HCC progression.
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Ji, Laixi, Haijun Wang, Yuxia Cao, Ping Yan, Xiaofei Jin, Peirui Nie, Chaojian Wang, et al. "Sharp-Hook Acupuncture (Feng Gou Zhen) for Patients with Periarthritis of Shoulder: A Randomized Controlled Trial." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/312309.
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TheFeng Gou Zhen(sharp-hook acupuncture) as a traditional form of ancient acupuncture is said to be particularly effective for managing periarthritis of shoulder. We conducted this randomized controlled trial to evaluate the effectiveness ofFeng Gou Zhenas an add-on compared to conventional analgesics for patients with PAS. 132 patients were randomly assigned in a 1 : 1 ratio to either a acupuncture group receiving sharp-hook acupuncture plus acupoint injection with conventional analgesics or a control group. Patients from both groups were evaluated at week 0 (baseline), week 1, and week 4. The primary outcome measure was the change from baseline shoulder pain, measured by Visual Analogue Scale at 7 days after treatment. Secondary outcome measures include the (i) function of shoulder joint and (ii) McGill pain questionnaire. The results showed that patients in acupuncture group had better pain relief and function recovery compared with control group (P<0.05) at 1 week after treatment. Moreover, there were statistical differences between two groups in VAS and shoulder joint function and McGill pain questionnaire at 4 weeks after treatment (P<0.05). Therefore, the sharp-hook acupuncture helps to relieve the pain and restore the shoulder function for patients with periarthritis of shoulder.
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Lopes, Kelvin Saldanha, Francisco Willyego Holanda Maciel, Roque Soares Martins Neto, Vilana Maria Adriano Araújo, Juscelino de Freitas Jardim, and Mardonio Rodrigues Pinto. "Aplicações e possibilidades terapêuticas do uso do biomaterial quitosana para a odontologia: revisão de literatura." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (April 20, 2020): 587–91. http://dx.doi.org/10.21270/archi.v9i6.4782.
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A quitosana, polissacarídeo linear obtido a partir do exoesqueleto de crustáceos e artrópodes, tem sido pesquisada em Odontologia por suas diversas propriedades terapêuticas. O objetivo do presente estudo foi realizar uma revisão da literatura sobre as aplicações atuais e as possibilidades terapêuticas da quitosana na odontologia. A busca foi realizada através do banco de dados eletrônico do Pubmed, utilizando os descritores Quitosana, Odontologia e Biomateriais. Foram incluídas pesquisas científicas utilizando quitosana em diversas áreas da odontologia e excluídas revisões de literatura e estudos não odontológicos, sendo selecionados 13 artigos. A quitosana induz resposta transcricional e anti-inflamatória em fibroblastos gengivais sobre citocinas inflamatórias, fatores transformadores do crescimento (TGF -β) e fatores de crescimento tumoral (TNF-α) que estão diretamente relacionados à atividade patológica periodontal. Nas infecções endodônticas persistentes, a substância atua criando ligações de hidrogênio e liberação de íons cálcio, o que potencializa a ação dos irrigadores intracanal, além de causar menos estresse oxidativo. Para a odontologia restauradora, a quitosana demonstrou eficácia como auxiliar no condicionamento da dentina e mostrou potencial para induzir a migração de odontoblastos na proteção do complexo dentino-pulpar. A substância atua como uma cura de feridas orais devido à sua capacidade de estimular a formação de fibroblastos e novos vasos sanguíneos, além de células anti-inflamatórias.
Descritores: Biopolímeros; Biomateriais; Biotecnologia.
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