Dissertations / Theses on the topic 'Guillain-Barre Syndrome'
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1
Pritchard, Jane. "Immune responses to myelin proteins in Guillain-Barre syndrome." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414411.
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MICHELAT, CORINNE. "Les polyradiculonevrites aigues de l'enfant (syndrome de guillain-barre)." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13002.
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Tam, Clarence. "Campylobacter and other pathogens as causes of Guillain-Barre syndrome." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429188.
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Merlet-Chicoine, Isabelle. "Aspects electrophysiologiques precoces du syndrome de guillain-barre : criteres pronostiques, a propos de 12 observations." Angers, 1991. http://www.theses.fr/1991ANGE1076.
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Charif, Mahmoud. "Les polyradiculonévrites aigues : étude rétrospective de 137 cas." Montpellier 1, 2000. http://www.theses.fr/2000MON11109.
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Press, Rayomand. "Immunopathogenesis of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-378-3/.
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Marliere, Christine. "Le synrome de fisher." Amiens, 1989. http://www.theses.fr/1989AMIEM058.
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Forsberg, Anette. "Guillain-Barré syndrome: disability, quality of life, illness experiences and use of healthcare /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-838-X/.
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Cuvellier, Jean-Christophe. "Efficacite des immunoglobulines intraveineuses dans le syndrome de guillain-barre de l'enfant : comparaison a un groupe controle, 21 observations." Lille 2, 1991. http://www.theses.fr/1991LIL2M184.
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GOURDIAT, ANNE. "Atteintes neurologiques au decours d'infections a campylobacter : cinq observations." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF13015.
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LAIRE, TACHE EMMANUELLE. "Echanges plasmatiques et syndrome de guillain-barre : experience remoise dans le cadre de l'etude multicentrique francaise prn 85." Reims, 1992. http://www.theses.fr/1992REIMM056.
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Barlaud, Véronique. "Les formes axonales des polyradiculonévrites inflammatoires." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M187.
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Rees, Jeremy Harry. "An investigation into the association between Campylobacter jejuni infection and Guillain-Barre syndrome." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281775.
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Maire, Olivier. "Avenir fonctionnel et rééducation du syndrome de Guillain et Barré d'évolution prolongée." Montpellier 1, 1991. http://www.theses.fr/1991MON11176.
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CORBARIEU, PERRAULT JOELLE. "Le traitement du syndrome de guillain barre en pediatrie : etude retrospective soins conventionnels versus echanges plasmatiques ; a propos de 24 cas." Toulouse 3, 1994. http://www.theses.fr/1994TOU31056.
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MIESCH, BARBARA. "Neuropathies aigues a forme axonale : une nouvelle entite ?" Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M156.
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Chetty, Sarvani. "Guillain Barre Syndrome (GBS) in Cape Town, South Africa: a descriptive outcomes cohort study." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31166.
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INTRODUCTION
Guillain-Barré syndrome (GBS) or acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is an important cause of acute severe and life-threatening weakness. It occurs worldwide and may affect all age groups, but varies widely in clinical presentation, subtype, electrophysiology, course and outcome. There is sparse literature on GBS in low and middle income countries (LMIC), and the effect, if any, of HIV on GBS. This observational cohort study aims to describe the clinical presentation and outcome of acute GBS in Cape Town, South Africa, in participants recruited into the International Guillain-Barré Syndrome Outcome Study (IGOS). A secondary aim, given the high HIV prevalence in South Africa, is to describe and compare GBS participants with and without HIV infection.
METHODS
Between 1 June 2014 and 31 January 2017, we recruited participants 18 years or older presenting to Groote Schuur Hospital in Cape Town with acute GBS (< 2 weeks onset of symptoms) who were available for 1 year follow up. We recorded demographic, clinical, laboratory, electrophysiological and treatment data at entry. At follow-up at weeks 4, 26 and 52, GBS-related complications and GBS disability scale scores (GDSs) were evaluated. A good outcome was defined as the ability to walk unaided (GDSs 2) by 6 months. The clinical presentation and outcomes of HIV-uninfected and -infected participants were compared.
RESULTS: Of 31 recruited participants, 1 participant was re-diagnosed as acute onset-CIDP and excluded from the study and 1 participant demised of an unrelated cause within the first week. 19 participants were male and the median age was 40 years. Reported antecedent infections (73%), co-morbid HIV infection (30%) and tuberculosis (15%) were frequently seen. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP; 67%) and acute motor axonal neuropathy (AMAN; 17%) were the most common phenotypes. Overall, GBS-related complications occurred in 46% of participants. The major complication was pneumonia which occurred in 23% of the total group, and all required intubation/ventilation. Other septic complications (drip site or systemic) were less common, 6% of the entire group. At entry, 83% had GDSs >4 indicating severe disability. The ability to walk unaided was regained by 37% at 4 weeks, 75% at 6 months and 79% at 1 year. Three participants remained severely affected at 1 year (GDSs of >3). There were no differences in antecedent infections, treatments given, or motor outcomes between HIV-infected and -uninfected GBS participants apart from a trend towards higher CSF protein in the HIV-infected group (p-value 0.05). AIDP was the most common GBS variant in both groups. AMAN was only seen in the HIV-uninfected group, whereas Miller Fisher 5 syndrome (MFS) was more common in the HIV-infected group. However, the numbers were too small to reach statistical significance.
CONCLUSION
Infections with HIV and tuberculosis frequently co-occurred with acute GBS, whether this reflects true disease association or merely high background disease prevalence cannot be confirmed by this study. AIDP is the most common phenotype unlike other LMIC regions such as Asia where AMAN predominates. In this cohort, 76% of participants showed good outcomes being able to walk unaided or having no/minor symptoms by 6 months. However, of the remainder only 1 showed significant recovery at 1 year. HIV participants had similar clinical presentations, complications and outcomes compared to the HIV-uninfected group. Mortality was low.
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Braun, Anne. "Syndrome de Guillain-Barre et grossesse : à propos d'un cas : revue de la littérature." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR1M149.
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BOULESTEIX, AUBERT MARIE-ANGE. "Depistage des anomalies de la conduction proximale par stimulations etagees du nerf cubital au cours du syndrome de guillain-barre." Limoges, 1989. http://www.theses.fr/1989LIMO0174.
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McLean, Mark Edward. "The incidence of Guillain-Barre syndrome in Ontario and Quebec, 1983-1989, using hospital-service databases." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7478.
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Background. Guillain-Barre syndrome (GBS) is of public health interest in Canada, as well as the rest of North America, for two main reasons. It is occasionally a vaccine-associated adverse event and is also a differential diagnosis of poliomyelitis. Objectives. (1) To ascertain the incidence of GBS in the Canadian provinces of Ontario and Quebec for the years 1983-1989, inclusive. (2) To demonstrate the feasibility of measuring the incidence of GBS through internal record linkage of Canadian hospital-service data. Results. 1,302 and 1,031 records representing GBS incident admissions in Ontario and Quebec, respectively, were identified through the record-linkage procedure. The mean annual GBS incidence after age-and-sex-standardization to the 1986 Canadian census population was 2.02 per 100,000 person-years in Ontario and 2.30 in Quebec. The incidence was higher in older age-strata in both provinces (70-80 years), and was higher in males (M:F = 1.1). Reviews of charts of incident admissions of GBS cases reveal that 26.2%-32.6% of Ontario cases and 21.0%-24.0% of Quebec cases may be false positive diagnoses. No possible false negative cases were identified through chart review. Cross linkage of records belonging to the other province with records from the other dataset revealed 0.5% false negative misclassification of Ontario incident admissions and 1.8% for Quebec. Mortality figures obtained from CMDB were in both provinces less than those obtained in the hospital service data, indicating that it is unlikely a significant number of GBS cases die before reaching hospital. Conclusions. (1) It is possible to internally link records in the HMRI and Med-Echo databases into personal histories (cases) of a condition. (2) The high percentage of false positive misclassifications discovered on examination of incident admissions raises concern about the validity of HMRI and Med-Echo data for epidemiological purposes. (Abstract shortened by UMI.)
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Lin, Hsin Hsin. "Mechanisms of Intravenous Immunoglobulin in the Treatment of Experimental Autoimmune Neuritis." University of Sydney, 2007. http://hdl.handle.net/2123/1696.
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PhDThe aims of this study were to test the efficacy of immunoglobulin and its Fab and Fc fragment in the treatment of experimental autoimmune neuritis (EAN) in Lewis rats, to investigate which portion of immunoglobulin is operative in the effect of IVIg, and to clarify the possible mechanisms by which immunoglobulin exerts its action in the treatment of rats EAN. EAN was induced by immunization with whole bovine peripheral nerve myelin. The immunized rats were randomized into groups, assessed clinically, electrophysiologically, and histologically, and intravenously injected with normal saline, albumin, human IVIg preparation, purified Fab or Fc fragments. The treatment efficacy was compared between normal saline and albumin groups, albumin and IVIg groups, albumin and Fab groups, albumin and Fc groups, Fab and Fc groups, Fab and IVIg groups, and Fc and IVIg groups. Methods of myelin isolation, antibody purification, and Western blot techniques were also applied. The results revealed that treatment with Fc fragment and IVIg at the onset of signs of disease effectively prevented further progression of disease, shortened disease duration, and facilitating recovery from illness as shown in clinical, electrophysiological and histological parameters. In the study which the efficacy of albumin and IVIg was compared, 5 out of 17 rats (29%) in the albumin group and 12 out of 17 (71%) in the IVIg group completely recovered from the clinical disease by day 30. The animals receiving IVIg treatment exhibited lower clinical scores, less prolongation of S wave latencies, better maintained S wave amplitudes, less reduction of distal motor NCVs, better maintained distal and proximal CMAP amplitudes, and lower histological grades. In the study which the efficacy of albumin, Fab fragment, Fc fragment, and IVIg was compared, 0 out of 8 (0%) in the albumin group, 1 out of 8 (13%) in the Fab group, 4 out of 8 (50%) in the Fc group, and 6 out of 9 (67%) rats in the IgG group completely recovered from the clinical disease by day 30. The animals receiving Fc fragment and IVIg treatment exhibited lower clinical scores, less prominent weight loss, less prolongation of S wave latencies, better maintained S wave amplitudes, less reduction of distal motor NCVs, better maintained distal and proximal CMAP amplitudes, and lower histological grades.
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Berdaï, Driss. "La maladie de Guillain-Barré et les échanges plasmatiques : à propos de trente cinq cas relevant de techniques de réanimation." Bordeaux 2, 1990. http://www.theses.fr/1990BOR25121.
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LIMA, MYLENE. "Manifestations neurologiques de la maladie de lyme chez l'enfant : a propos de trois observations et de leur etude critique." Toulouse 3, 1994. http://www.theses.fr/1994TOU31060.
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Lin, Hsin Hsin. "Mechanisms of Intravenous Immunoglobulin in the Treatment of Experimental Autoimmune Neuritis." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/1696.
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The aims of this study were to test the efficacy of immunoglobulin and its Fab and Fc fragment in the treatment of experimental autoimmune neuritis (EAN) in Lewis rats, to investigate which portion of immunoglobulin is operative in the effect of IVIg, and to clarify the possible mechanisms by which immunoglobulin exerts its action in the treatment of rats EAN. EAN was induced by immunization with whole bovine peripheral nerve myelin. The immunized rats were randomized into groups, assessed clinically, electrophysiologically, and histologically, and intravenously injected with normal saline, albumin, human IVIg preparation, purified Fab or Fc fragments. The treatment efficacy was compared between normal saline and albumin groups, albumin and IVIg groups, albumin and Fab groups, albumin and Fc groups, Fab and Fc groups, Fab and IVIg groups, and Fc and IVIg groups. Methods of myelin isolation, antibody purification, and Western blot techniques were also applied. The results revealed that treatment with Fc fragment and IVIg at the onset of signs of disease effectively prevented further progression of disease, shortened disease duration, and facilitating recovery from illness as shown in clinical, electrophysiological and histological parameters. In the study which the efficacy of albumin and IVIg was compared, 5 out of 17 rats (29%) in the albumin group and 12 out of 17 (71%) in the IVIg group completely recovered from the clinical disease by day 30. The animals receiving IVIg treatment exhibited lower clinical scores, less prolongation of S wave latencies, better maintained S wave amplitudes, less reduction of distal motor NCVs, better maintained distal and proximal CMAP amplitudes, and lower histological grades. In the study which the efficacy of albumin, Fab fragment, Fc fragment, and IVIg was compared, 0 out of 8 (0%) in the albumin group, 1 out of 8 (13%) in the Fab group, 4 out of 8 (50%) in the Fc group, and 6 out of 9 (67%) rats in the IgG group completely recovered from the clinical disease by day 30. The animals receiving Fc fragment and IVIg treatment exhibited lower clinical scores, less prominent weight loss, less prolongation of S wave latencies, better maintained S wave amplitudes, less reduction of distal motor NCVs, better maintained distal and proximal CMAP amplitudes, and lower histological grades.
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Castro, Fabiano Roberto de. "Efeito da crotapotina na evolução clinica da neurite experimental autoimune (EAN)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310330.
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Orientador: Leonilda Maria Barbosa dos SantosDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A Síndrome de Guillain-Barré (SGB) é uma doença desmielinizante do sistema nervoso periférico (SNP). Baseado principalmente nas similaridades clínicas e histopatológicas a Neurite Experimental Auto-imune (EAN) tem sido extensivamente usada como modelo de estudo da SGB. A EAN é uma doença auto-imune, que pode ser experimentalmente induzida em ratos geneticamente suscetíveis através da imunização com os componentes da mielina de nervos periféricos tais como os peptídeos P0 e P2 , ou ainda por transferência adotiva de lifócitos T CD4+ do tipo Th1. Diferentes tentativas de tratamentos para a SGB têm sido estudadas, dentre elas pode-se citar a plasmaferese, o uso de anticorpos monoclonais, administração de corticóides e a imunossupressão global através da administração de intérferon ß. A utilização de venenos totais de serpentes, ou frações deles, já demonstrou bons resultados na tentativa de tratamento de alguns modelos de doenças auto-imunes como a diabetes auto-imune insulino dependente, lúpus e encefalomielite experimental auto-imune (EAE). No presente trabalho foi estudado o efeito de uma fração do veneno da cascavel sul americana Crotalus durissus terrificus (Cdt), a crotapotina, no modelo de EAN. São apresentadas evidências de que tanto a administração intraperitoneal (IP) como a oral de crotapotina reduz significativamente a gravidade da EAN induzida em ratos Lewis, associada a um significativo declínio na resposta proliferativa das células T neuritogênicas, assim como diminuição de infiltrados de células mononucleares no nervo ciático dos os animais
Abstract: Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin which is a fraction of the venom of the rattlesnake Crotalus durissus terrificus, has been described as an antinflammatory that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal (IP), as well as oral administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré Syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating in the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide
Mestrado
Ciencias Basicas
Mestre em Clinica Medica
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Britto, Alexandre Paulo Machado de. "Custo-efetividade do uso de imunoglobulina intravenosa e de plasmaferese no tratamento da síndrome de Guillain-Barré no Hospital de Clínicas de Porto Alegre." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/148859.
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Objetivo: Comparar as relações de custo-efetividade de duas terapias, Imunoglubulina Intravenosa (IgIV) e Plasmaferese (PE), no tratamento da Síndrome de Guillain-Barré sob a perspectiva do sistema público (SUS). O objetivo secundário foi avaliar a adesão às recomendações da Comissão de Medicamentos do HCPA Métodos: estudo transversal com análise econômica de pacientes tratados por Síndrome de Guillain-Barré no período de junho de 2003 a junho de 2008 no Hospital de Clínicas de Porto Alegre (HCPA). Foi realizada análise de custo-efetividade do emprego de IgIV e de PE nestes pacientes, pelo método de minimização de custos, considerando-se somente os custos diretos sanitários, fornecidos pelo sistema gerencial da instituição . Foram excluídos os pacientes que usaram outro tipo de tratamento associado ou isolado. Coletaram-se os dados através da revisão dos prontuários. A gravidade da doença na internação foi classificada como: doença leve, quando caminhar foi possível; doença moderada, quando caminhar foi impossível; doença grave, quando os pacientes necessitaram de ventilação assistida. A incapacidade na alta foi estabelecida pela escala de sete pontos de Hughes. A adesão às recomendações da Comissão de Medicamentos do HCPA, objetivo secundário, foi avaliada através da dose e o esquema de prescrição da IgIV. Resultados: Vinte e cinco participantes (2 a 70 anos) foram incluídos no estudo, cinco tratados com PE, empregando-se Albumina Humana como substituto do plasma, e 20 tratados com IgIV. O custo total do tratamento de um paciente com PE foi R$10.603,88 (± 2.978,12) e o de um que recebeu IgIV foi R$ 32.103,00 (± 21.454,24). O custo total da internação foi de R$45.027,14 (± 32.750,45) para os tratados com PE e de R$ 60.844,28 (±48.590,52) para os que receberam IgIV. Em relação ao desfecho clínico principal, melhora na escala de incapacidade de sete pontos, após o tratamento com uma das alternativas escolhida, a mediana dos pacientes que internaram com grau de gravidade 3 e que foram tratados com PE foi igual a dos que receberam IgIV. Em relação à permanência hospitalar, permanência em UTI e dias de Ventilação Mecânica, não houve diferença estatisticamente significativa entre os dois tratamentos. Conclusões: Quando comparados os custos médios das duas opções terapêuticas, uma delas aparece claramente com menor custo. Quando comparados os desfechos, após o emprego de cada opção terapêutica, estes não revelam diferença. Concluímos que, no HCPA, a opção pelo procedimento Plasmaferese é mais custo efetiva do que o emprego da IgIV.Objectives: To compare the cost-effectiveness of two distinct therapies, Intravenous Immunoglobulin (IVIg) and Plasma Exchange (PE) in the treatment of Guillain-Barré Syndrome, concerning the public health care system. Compliance to the guidelines of the Pharmacy and Therapeutics Committee of the Hospital de Clínicas de Porto Alegre was a secondary objective. Methods: A cross-sectional, economical analysis was conducted, including patients treated for GBS in the period from June, 2003 through June, 2008 in Hospital de Clínicas de Porto Alegre (HCPA). The cost-effectiveness of the use of IVIg and PE in such patients was studied through the cost minimization method, considering direct medical costs only (2008 currency), yield by the management of the institution. Patients receiving treatments other than PE or IVIg were excluded. Data were collected by chart reviews. Severity of disease on admittance was classified as follows: mild disease, when the patient was able to walk; moderate disease, when the patient was unable to walk, and severe disease, when assisted ventilation was required. Disability on discharge was established by the 7-point scale of Hughes. Compliance to the guidelines of the Pharmacy and Therapeutics Committee was evaluated through the dose and prescription scheme of IVIg. Results: Twenty-five participants (2 to 70 years of age) were included in the study, 5 were submitted to treatment with PE, using human albumin as replacement for plasma, and 20 were treated with IVIg. The total treatment cost for PE in a single patient was US$6,058.85 (±1,701.78 SD), and the same expense for IVIg was US$18,344.57 (± 12,259.56 SD) (p = 0.035). Total inpatient cost was US$25,729.79 (± 18,714.54 SD) in the PE group, and US$34,768.16 (±27,766.01 SD) (p=0.530) in the IVIg group. The main clinical outcome was improvement in the 7-point disability grade scale. The median of that measure in patients admitted with a severity grade 3 treated either with PE and IVIg was the same. Secondary outcomes, such as in-hospital stay, ICU stay, and number of days on mechanical ventilation revealed no statistically significant difference between treatments. Conclusions: As the mean expenses of both therapeutic options are compared, one clearly stands-out as less onerous. Clinical outcomes, when compared, reveal no statistical difference after each treatment. We concluded that, in HCPA, plasma exchange is more cost-effective than intravenous immunoglobulin.
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Pradella, Fernando 1987. "Efeito da administração do G-CSF nos mecanismos efetores e imunorreguladores na neurite experimental autoimune induzida em ratos Lewis = Effect of the administration of the G-CSF onto the effector and immuneregulatory mechanisms of the experimental autoimmune neuritis induced in Lewis rats." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316429.
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Orientadores: Alessandro dos Santos Farias, Leonilda Maria Barbosa dos SantosDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Abstract: The abstract is available with the full electronic document
Mestrado
Imunologia
Mestre em Genética e Biologia Molecular
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Williams, Rhonda Nicole. "A study to determine victims of Guillain-Barre' syndrome attitudes and beliefs about the effectiveness of an on-line support group as a way of coping with the disease." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1998. http://digitalcommons.auctr.edu/dissertations/479.
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The purpose of this study was to examine victims of Guillain-Barre’ syndrome attitudes and beliefs about the effectiveness of the on-line support group as a way of coping with the disease. The sample for this study consisted of 10 adults from the United States, 10 from the United Kingdom, and 10 from Europe and Canada. The population in this study had attended or were presently attending a support group for Guillain-Barre’ victims. A questionnaire consisting of 35 items was administered via the internet. The variables tested were general attitudes towards support groups and beliefs about the effectiveness of the support group. The participants were asked demographic questions as well. The results were analyzed by cross-tabulation to detennine a relationship between variables. The findings indicated the participants in the study had positive attitudes and beliefs about the effectiveness of the support group.
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Kvarnström, Maria. "Mechanisms in inflammatory demyelinating diseases of the nervous system : immunological and methodological aspects /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med892s.pdf.
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Tang, Hsiang Yu, and 唐湘瑜. "Bomarkers in Guillain-Barre Syndrome." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/32017208389618660462.
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碩士長庚大學
醫學生物技術研究所
97
Guillain-barre syndrome (GBS) is an autoimmune inflammatory disease of the peripheral nervous system that characterized by demyelination. Lipid peroxidation is a major outcome of free radical-mediated injury to nervous system like multiple sclerosis patients. Although it has been hypothesized that oxidative stress is a risk factor in neuron demyelinating disease, the definitive evidence for such hypothesis in GBS is still lacking. The objectives of the current study were two folds. One was to determine oxidative damage and antioxidants and the other objective was to apply the LC/MS-based metabolomic approach to detect metabolic profiling in patients with GBS. The plasma levels of lipid peroxidation marker malondialdehyde and inflammatory marker myeloperoxidase were not significantly different between control and GBS patients. The fat-soluble antioxidants γ-tocopherol was significantly reduced in GBS patients. Vitamin E metabolites such as γ, δ, α-CEHC were not significantly different between GBS patients and controls. Based on LC/MS-based metabolomic approach, fifty-seven metabolites were significantly different between GBS patients and control samples. There molecular weights such as mass 113.0589 and 125.0147 were significantly reduced in GBS patients, mass 467.2976 and 533.3511were significantly increased in GBS pateints. These disturbances in plasma metabolites are likely due to metabolic changes in GBS disease. These metabolites may be potential biomarkers for the evaluation of GBS disease.
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Janse, van Rensburg Anna Catharina. "Die belewenis van Guillain Barre-pasiente tydens verpleging in intensiewesorgeenhede." Thesis, 2012. http://hdl.handle.net/10210/6925.
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M.Cur.The purpose of this study is to explore and describe the experiences of patients with Guillain-Barré syndrome whilst being nursed in intensive care units, in order to set guidelines for nursing. The researcher made use of the phenomenological approach within the paradigm of qualitative research. The target population consisted of 70 patients of which seven complied with the selection criteria: In-depth interviews, which were taped, were conducted with the patients. Validity and reliability were ensured by using measures as stated by Woods and Catanzaro (1988). Data-analysis was executed by means of Giorgi's method (Omery,1983) and after clearance with an external decoder, it was categorized according to the patients' internal and external environment. The Nursing Theory for the Wholeperson had been used to this purpose. The conclusions of this study indicate that patients with Guillain-Barré syndrome in intensive care units experience deprivation of sleep, pain and fear. Limited communication and loss of autonomy create frustration. Patients become lonely and bored and have a need for constant support from their family and others. Consequent upon the conclusions the researcher developed nine guidelines for the nursing of patients with Guillain-Barré syndrome. These guidelines are in support of the functional approach of the researcher and may be considered an attempt to provide research findings that are applicable to the practice of nursing.
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Jones, DA. "A study of the epidemiology, phenotypic and genotypic characteristics of Guillain Barre syndrome associated campylobacteriosis." Thesis, 2003. https://eprints.utas.edu.au/20799/7/whole_JonesDavidAdam2003.pdf.
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Guillain-Barre syndrome (GBS) is a neurological disease characterised by ascending paralysis that can lead to respiratory muscle compromise and death. Although the exact trigger of GBS is unknown, case control studies have shown that it often follows an acute infectious illness. In recent years, serological and cultural studies have suggested that Campylobacterjejuni is the infectious agent most commonly associated with the development of GBS. Culture confirmation of C. jejuni infections has been achieved in up to 50% of GBS patients, in spite of the fact that many GBS patients with antecedent Campylobacter infection are likely to have already cleared their stools of the organism by the time neurological symptoms begin. Campylobacter infection is now classified as the most common cause of bacterial food poisoning in the Western world. In Tasmania, over 400 cases are notified each year. Given this prevalence it is not clear why only a small number of patients with C. jejuni enteritis develop GBS whilst the majority do not. Two possibilities exist; the first being that susceptibility is determined by host-specific factors; the second is that bacterial strain-specific factors determine whether patients develop GBS. The aim of this investigation is to determine the importance of the second factor. The specific objectives being to define specific bacterial markers that might be used to determine those strains of Campylobacter associated with the development of GBS.
The way in which infection with C. jejuni leads to GBS is unknown, however, there is evidence suggesting that Gml ganglioside in the core of the lipopolysaccharide of certain strains of C. jejuni may stimulate an immune response to this epitope in infected patients. It is hypothesized that this immune response may then lead to an autoimmune peripheral neuropathy because the Gml in the bacteria is identical to that in the nerve cell.
This study investigated the epidemiology of Campylobacter infection within the Tasmanian community by collecting isolates from patients notified to the Department of Health in Tasmania. This culture collection was then used to develop a robust method for speciation of isolates. This included development of a multiplex PCR for the hippurate gene/16S rRNA gene with subsequent dot blot hybridisation using labeled probes. Using this system, 237 enteritis strains were identified as C. jejuni, 10 C. co/i, 2 C. lari and 1 C. upsaliensis.
C. jejuni serotype 0:19 appears to be over-represented in most published studies of GBS but campylobacters of this serotype do not account for all Campylobacter isolates from GBS patients. Potential markers of GBS-associated campylobacters investigated in the present study included the use of a Cholera Toxin Binding Assay for Gml -like epitopes in bacteria cell walls, a PCR for serotype 0:19 strains and Pulsed Field Gel Electrophoresis (PFGE). While 33% of all Tasmanian strains were found to be Gml positive, no isolates were found to belong to the serotype 0:19. Further, computer-assisted analysis of PFGE profiles showed no similarity between GBS strains of C. jejuni and Tasmanian strains of Campylobacter.
Subtractive hybridisation was used to produce a DNA library containing sequences that are over-represented in GBS-associated strains of C. jejuni. This library has been used to screen GBS and non-GBS-associated strains of C. jejuni. A unique DNA sequence, present only in the GBS-associated strains, has been identified and a PCR-based assay developed to detect this gene (Veh). The gene has homology to a sequence (Cj1013c), determined as part of the recently completed C. jejuni genome sequencing project, which is a gene of unknown function. Further studies to define gene function have been hampered by the lack of a suitable mutagenesis system for C. jejuni. Veh has been cloned in a shuttle vector to enable its mobilisation into other transfer systems.
It is hoped that in the future, identification of Campylobacter strains containing the Veh gene will lead to prompt treatment of patients infected with these strains thereby decreasing the incidence of GBS and its associated morbidity and mortality.
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Tang, Hsiang Yu, and 唐湘瑜. "Applications of liquid chromatography-mass spectrometry based metabolomics approach to redox signaling in glucose-6-phosphate dehydrogenase deficient red blood cells and potential clinical diagnosis of Guillain-Barre syndrome." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/27084892716671797251.
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Keithlin, Jessica. "A Systematic Review, Meta-Analysis and Meta-Regression of the Proportion of Campylobacter, Non- typhoidal Salmonella and E. coli O157 Cases that Develop Chronic Sequelae." Thesis, 2012. http://hdl.handle.net/10214/5198.
Full textAbstract:
Understanding of chronic sequelae development after infection with foodborne pathogens is limited and an increased understanding could assist with the development of more accurate burden of disease estimates. The purpose of this thesis was to determine via systematic review and meta-analysis of the published international literature, the proportion of cases of Salmonella, Campylobacter and E. coli O157 that will develop the chronic sequelae of reactive arthritis, haemolytic uraemic syndrome, irritable bowel syndrome, inflammatory bowel disease or Guillain Barré syndrome. This information can be used to increase our understanding of the relationship between infection and the development of long term health complications while providing a key piece of information for the development of accurate burden of disease estimates.Canadian Institutes of Health Research Institute of Population and Public Health/Public Health Agency of Canada, Applied Public Health Research Chair (awarded to Jan M. Sargeant)
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Schmitz, Sabine. "Infektionen durch Mycoplasma pneumoniae in Franken in den Jahren 2000-2003 : Untersuchungen eines Ausbruches in Ebrach sowie stationärer Patienten der Universitätskinderklinik Würzburg." Doctoral thesis, 2010. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-51713.
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Die Studie diente der retrospektiven Untersuchung des Ausbruches von Mp-Infektionen in Ebrach, Franken, der von Oktober des Jahres 2000 bis Februar 2001 andauerte. Ziel war es, die epidemiologischen Charakteristika, also Informationen zu Verteilung und Ausbreitungsweisen der Erkrankung, aber auch zu Symptomen und Befunden, Manifestationsformen und Komplikationen, Therapie und Diagnostik zu erhalten. Darüber hinaus sollten Erkenntnisse zu Patienten mit Mykoplasmeninfektionen, die in den Jahren 2000 bis 2003 in der Universitätskinderklinik Würzburg behandelt wurden, gewonnen und mit Daten der Patienten aus Ebrach verglichen werden. In Ebrach bestand bei 177 Patienten der Verdacht einer akuten Mykoplasmeninfektion. Ausgehend von einer dritten Grundschulklasse, die einige Tage geschlossen werden musste, da innerhalb von 16 Tagen 9 Schüler an einer Pneumonie und 3 Schüler an einer Bronchitis erkrankt waren, hatte sich die Infektion auf insgesamt 78 Personen, vor allem Familienmitglieder, aber auch Nachbarn und Freunde der betroffenen Schüler ausgebreitet. Die meisten Patienten klagten über Husten und Fieber. In erster Linie traten Entzündungen des unteren Respirationstraktes (50% Bronchitiden, 38,5% Pneumonien) auf. Bei 9 Patienten wurde ein Exanthem beobachtet. Eine Patientin musste wegen eines Guillain-Barré-Syndroms in der neurologischen Abteilung der Universitätsklinik Würzburg behandelt werden. In den Jahren 2000 bis 2003 bestand bei 125 Patienten der Universitätskinderklinik Würzburg der Verdacht auf Vorliegen einer Mp-Infektion. Bestätigt wurde dieser in 43 Fällen. Die Patienten waren zwischen 3 und 16 Jahre alt. Insgesamt waren etwas mehr Jungen betroffen, Komplikationen traten deutlich häufiger bei Mädchen auf. Die Patienten, die einer stationären Behandlung bedurften, wiesen schwerere Erkrankungsverläufe oder seltenere Manifestationsformen auf (65% Pneumonien, 34% Komplikationen). So wurden unter anderem 6 Patienten mit Mykoplasmen-assoziierter Fazialisparese, 4 Patienten mit Meningitis und jeweils ein Patient mit Enzephalitis, Trochlearisparese, Vestibularisausfall, Hörverlust, Perimyokarditis und Uveitis anterior und nephrotischem Syndrom beobachtet. Pathognomonische Befunde konnten weder unter den Ebracher Patienten noch in der Kinderklinik ausgemacht werden. Vielmehr spricht die Konstellation bestimmter Symptome und Untersuchungsergebnisse wie Husten, Fieber, relativ guter Allgemeinzustand bei radiologischem Pneumonienachweis oder Differenz der Blutsenkungsreaktion bei Raumtemperatur und 4°C für das Vorliegen einer Mykoplasmeninfektion. Eine deutliche Erhöhung der Inzidenz von Mykoplasmeninfektionen in der Kinderklinik im Zeitraum des Ausbruches von Ebrach war nicht zu verzeichnen. Dass Schüler als Überträger der Infektion in Familien und unter Spielkameraden fungieren, war bekannt, die Ausbreitung der Erkrankung innerhalb des Klassenzimmers ist jedoch selten in diesem Ausmaß beobachtet worden und verdient weitere Untersuchungen. Festzuhalten bleibt also, dass bei der Diagnose einer Mykoplasmeninfektion mittels serologischer Methoden mit einer verzögerten Immunantwort zu rechnen ist und deshalb häufig ein Direktnachweis der Erreger mittels PCR notwendig wird. Darüber hinaus ist die Bestimmung der Blutkörperchensenkungsgeschwindigkeit bei Raum- und Kühlschranktemperatur ein einfaches Mittel, welches aber diagnostisch zusätzlich wichtige Hinweise auf eine Infektion mit Mycoplasma pneumoniae liefern kann. Im Gegensatz dazu erbringt die klinische Untersuchung häufig keine aussagekräftigen, diagnostisch weiterführenden Ergebnisse. Wichtig bezüglich der Therapie ist die frühzeitige und ausreichend lange (10 bis 14 Tage) Gabe von gegen Mykoplasmen wirksamen Antibiotika wie vor allem Makrolid-AntibiotikaThis is a retrospective study of an outbreak of Mycoplasma pneumoniae infections between october 2000 and february 2001 in Ebrach, Franken, Germany. We wanted to get information about epidemiologic characteristics, such as spread of infection, clinical manifestations and complications, as well as influence of therapy, and possibilities of diagnostics. Furthermore we monitored patients with Mycoplasma pneumoniae infections which led to hospitalisation in the pediatric department of Würzburg university hospital and compared them to the patients in Ebrach. In Ebrach a total of 177 patients were thought to have an MP infection. It started in year 3 of primary school, where within 16 days 9 pupils suffered from pneumonia due to MP and 3 children had MP bronchitis. For this reason the pupils where not allowed to attend school for a few days. Beginning with the school children the infection reached 78 persons, mainly parents of the children but also neighbours and friends for example from the football team. Most of them suffered from coughs and fever. Manifestations were infections of the lower respiratory tract (38,5% pneumonia, 50% bronchitis), 9 patients suffered from cutaneous symptoms (exanthema). One patient had to be hospitalized because of a Guillain-Barre-syndrom. Between 2000 and 2003, 125 patients of the pediatric department of the Würzburg university hospital were thought to have MP infections. In 43 cases the MP infection was diagnosed. Patients were between 3 and 16 years old, there were bit more cases amongst males but females got more complications. Hospitalized patients showed more severe manifestatons (65% pneumonia) or complications (34%). These were for example 6 children with Bells palsy, 4 children with menigitis and one of each of the following manifestations: encephalitis, cranial nerve palsy of trochlearis and vestibularis, hearing loss, permyocarditis, uveitis anterior, nephrotic syndrom. No special symptoms which could be said to be pathognomonic were found in either Ebrach or amongst the hospitalized patients. The special constellation of pathological findings much rather suggests a diagnosis of an MP infection: cough, fever, quite good clinical condition, radiographic evidence of pneumonia, different wsg results at 37°C and 4°C. The incidence of MP infections among hospitalized patients did not increase during the time of the outbreak in Ebrach. It is already known that pupils are possible vectors but such a spread of MP infection in the classroom has seldom been observed before and needs further investigation. Serologic diagnosis needs more time because of the delayed immune response of the host and this is why pcr is often necessary. Antibiotic treatment with effective drugs such as macrolides should be taken into consideration early and administered for a long enough period