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Relevant bibliographies by topics / Guided Tissue Regeneration

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Academic literature on the topic 'Guided Tissue Regeneration'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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Journal articles on the topic "Guided Tissue Regeneration"

1

Batwa, Mohammed, Rand Bakhsh, Zainab Alghamdi, Khaled Ageely, Abdullah Alzahrani, Abdullah Alshahrani, Khalid Mujthil, et al. "Regenerative Therapies in the Treatment of Periodontal Defects." JOURNAL OF HEALTHCARE SCIENCES 03, no. 08 (2023): 254–60. http://dx.doi.org/10.52533/johs.2023.30802.

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Regenerative therapies in periodontics have shown great potential in restoring damaged periodontal tissues. Techniques such as guided tissue regeneration (GTR) and guided bone regeneration (GBR) have been effective in promoting the regeneration of periodontal ligament, cementum, and alveolar bone. These approaches create a conducive environment for cell repopulation and exclusion of non-osteogenic cells, leading to successful periodontal tissue regeneration. Tissue engineering approaches, utilizing stem cells, growth factors, and biomaterial scaffolds, have also shown promise in regenerating multiple periodontal tissues simultaneously. However, challenges such as membrane exposure and infection need to be addressed. Emerging regenerative techniques, including enamel matrix derivatives (EMDs), stem cell-based therapies, growth factor delivery systems, and gene therapies, offer innovative strategies for periodontal defect treatment. Optimization of delivery systems, refinement of biomaterials, and advancements in gene therapy and tissue-specific biomaterials may further enhance the regenerative capacity of periodontal tissues. Despite challenges, regenerative therapies have the potential to revolutionize periodontics and improve clinical outcomes by addressing the root cause of periodontal diseases and promoting long-lasting tissue regeneration.

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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (June 1, 2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.

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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa soft tissue graft, bone graft, biomodifikasi akar gigi, guided tissue regeneration sertakombinasi prosedur-prosedur di atas, termasuk prosedur bedah restoratif yang berhubungan dengan rehabilitasi oral dengan penempatan dental implan. Pada tingkat selular, regenerasi periodontal adalah proses kompleks yang membutuhkan proliferasi yang terorganisasi, differensiasi dan pengembangan berbagai tipe sel untuk membentuk perlekatan periodontal. Rasionalisasi penggunaan guided tissue regeneration sebagai membran pembatas adalah menahan epitel dan gingiva jaringan pendukung, sebagai barrier membrane mempertahankan ruang dan gigi serta menstabilkan bekuan darah. Pada makalah ini akan dibahas sekilas mengenai 1. Proses penyembuhan terapi periodontal meliputi regenerasi, repair ataupun pembentukan perlekatan baru. 2. Periodontal spesific tissue engineering. 3. Berbagai jenis membran/guided tissue regeneration yang beredar di pasaran dengan keuntungan dan kerugian sekaligus karakteristik masing-masing membran. 4. Perkembangan membran terbaru sebagai terapi regenerasi penyakit periodontal. Tujuan penulisan untuk memberi gambaran masa depan mengenai terapi regenerasi yang menjanjikan sebagai perkembangan terapi penyakit periodontal. Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.

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Villar, Cristina C., and David L. Cochran. "Regeneration of Periodontal Tissues: Guided Tissue Regeneration." Dental Clinics of North America 54, no. 1 (January 2010): 73–92. http://dx.doi.org/10.1016/j.cden.2009.08.011.

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Wagle, ShreeprasadVijay, AmitArvind Agrawal, Dinaz Bardoliwala, and Chhaya Patil. "Guided tissue regeneration." Journal of Oral Research and Review 13, no. 1 (2021): 46. http://dx.doi.org/10.4103/jorr.jorr_11_20.

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5

Dowell, P., J. Moran, and D. Quteish. "Guided tissue regeneration." British Dental Journal 171, no. 5 (September 1991): 125–27. http://dx.doi.org/10.1038/sj.bdj.4807634.

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Gilbert Triplett, R. "Guided Tissue Regeneration." Atlas of the Oral and Maxillofacial Surgery Clinics 2, no. 2 (September 1994): 93–108. http://dx.doi.org/10.1016/s1061-3315(18)30135-5.

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Karring, Thorkild. "Guided Tissue Regeneration." Advances in Dental Research 9, no. 3_suppl (November 1995): 18. http://dx.doi.org/10.1177/0895937495009003s0901.

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Gómez, Felipe. "Update on Histological Evidence of Tissue Formed by Guided Pulp Tissue Regeneration." International Journal of Medical and Surgical Sciences 3, no. 2 (October 26, 2018): 881–88. http://dx.doi.org/10.32457/ijmss.2016.021.

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The goal of regenerative endodontics is to reinstate normal pulp function in traumatized, necrotic and infected teeth that would result in reestablishment of their functions, but still fail to re-establish real pulp tissue and give unpredictable results. The aim of this review was to compile and synthesize available information on the histological evidence of tissue pulp-dentinal complex formed through guided tissue regeneration. A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were “Pulp", "Dentin", "Regeneratión", "Tissue” and "Histologic". The search yielded about 140 articles; the interest were selected and downloaded in full text. The most encouraging studies regarding guided tissue regeneration have been described in case reports of immature teeth diagnosed with irreversible pulpitis in which the histology odontoblasts type cells were observed. However, there are no studies with long-term follow up on this type of therapy. Some treatment protocols might result in undesired and unpredictable outcomes. Efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth.

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Saravanakumar, R., M. Jananni, V. Arvind Raaj, and KR Vineela. "Guided Tissue Regeneration Membrane." Annals of SBV 3, no. 2 (2014): 7–13. http://dx.doi.org/10.5005/jp-journals-10085-3202.

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Laurell, Lars, and Jan Gottlow. "Guided tissue regeneration update." International Dental Journal 48, no. 4 (August 1998): 386–98. http://dx.doi.org/10.1111/j.1875-595x.1998.tb00701.x.

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Dissertations / Theses on the topic "Guided Tissue Regeneration"

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Gottlow, Jan. "New attachment formation by guided tissue regeneration." Göteborg : Dept. of Periodontology, University of Göteborg, 1986. http://catalog.hathitrust.org/api/volumes/oclc/17242123.html.

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Hattingh, André Christiaan. "A protocol to study tissue regeneration in alveolar bony defects /." Access to E-Thesis, 1999. http://upetd.up.ac.za/thesis/available/etd-01052007-135643/.

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Umeda, Hiroo. "In situ Tissue Engineering of Canine Skull with Guided Bone Regeneration." Kyoto University, 2009. http://hdl.handle.net/2433/124318.

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NARDO, TIZIANA. "Bioactive Membranes and Nanocoatings for Guided Tissue Regeneration in Periodontal Diseases." Doctoral thesis, Politecnico di Torino, 2015. http://hdl.handle.net/11583/2614171.

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Periodontal diseases are highly prevalent in population of all ages. Initiated by bacterial accumulation at the interface of bone and soft tissue, they lead to the loss of gingival tissue adherent to the root surface and, eventually, to tooth loss. Regenerative approaches to treat periodontitis offer exciting possibilities; guided tissue/bone regeneration (GTR/GBR) approaches are promising because, through the insertion of a physical barrier, they can exclude unwanted epithelial and gingival connective tissue cells from the healing area and allow bone tissue cells to repopulate the bony defect. Different resorbable and non-resorbable membranes have been developed. Expanded polytetrafluoroethylene (ePTFE) membranes are the “gold standard” for GTR/GBR applications but they are non-resorbable and they need a second surgical operation to repair dehiscence. Biodegradable synthetic membranes avoid a second surgical operation but they show drawbacks concerning the capacity of space maintenance, early/late absorption, mechanical properties and bacterial infection during degradation. Collagen membranes have advantages related to collagen biological properties but are characterized by low mechanical strength. The “ideal” membrane for use in periodontal regenerative therapy has yet to be developed. The main purpose of this thesis was the design of biologically active products, with improved osteoconductive and antimicrobial properties, for GTR/GBR applications in periodontal diseases. In a more traditional approach, a commercially available membrane (based on PTFE) was surface modified by environmentally friendly technique to allow rapid bone re-growth and exert antimicrobial action. Binding ability of 3,4-dihydroxy-DL-phenylalanine (DOPA) to samples of any type, size and shape was exploited to improve PTFE surface properties. In particular, a hydroxyapatite nanoparticles (HAp) coating was applied by DOPA self-polymerization on PTFE surface in the presence of HAp nanoparticles, to promote the bone re-growth properties of PTFE films. Chemical composition analysis demonstrated the successful deposition of polyDOPA and HAp on coated films. Morphological and topographical characterizations further confirmed the total surface coverage causing an increase in surface roughness (39.8±5.2 nm for PTFE films vs 236.5±12.0 nm for polyDOPA/HAp coated films) and wettability (110.8±2.8° for PTFE films vs 46.1±12.4° for polyDOPA/HAp coated samples). A discontinuous HAp coating was still present after 14 days of incubation of coated PTFE films in phosphate buffered saline. Pre-osteoblastic MC3T3-E1 cells cultured on polyDOPA/HAp coated films showed a pronounced increase of cell proliferation and adhesion. Regarding the antimicrobial action, silver nanoparticles (AgNPs) have been selected due to their good antimicrobial efficacy against bacteria, viruses and other eukaryotic micro-organisms. The successful deposition of AgNPs on PTFE surface, through the functional groups of DOPA, has been demonstrated by physico-chemical and morphological analyses. Nanoparticles exhibited a diameter around 68 nm and were homogeneously distributed on the surface. In vitro cell tests with fibroblast NIH 3T3 cells showed an inhibition of cells proliferation on AgNPs functionalized films after 3 days of culture, while good cell adhesion was observed with cells randomly distributed on sample surface and extensively spread. The antimicrobial efficiency was demonstrated against S. aureus and Ag release was sustained for at least 14 days. The mussel-inspired coated PTFE membrane could find potential application as GTR/GBR strategy for the treatment of periodontal diseases. In a highly innovative approach, a bi-layered bioabsorbable membrane was developed, by the assembly of a compact and a porous layer. GTR/GBR membranes can be considered an interface-implant between gingival connective tissue/epithelium and alveolar bone tissue. Developing a multi-component structure membrane with compositional and structural gradients that meet the local functional requirements could represent a challenge. Binary blends of poly(DL-lactide-co-ε-caprolactone) (PLCL) and poly(DL-lactide-co-glycolide) (PLGA) with various compositions (100/0, 75/25, 50/50, 25/75, 0/100 wt/wt) were prepared by solvent casting technique as compact layer of the bi-layered membrane. Morphological analysis did not evidence phase separation between PLCL and PLGA and the behavior of blend glass transition temperatures as a function of composition suggested some degree of blend compatibility. However, blends elastic modulus showed a negative deviation from the additive law of mixture. In vitro cell tests with fibroblast NIH 3T3 cells showed improved cell adhesion and growth on PLCL/PLGA 25/75 blend. Due to its biocompatibility, its superior mechanical properties (E=10.2±0.6 MPa, σmax=0.8±0.0 MPa, and εmax=548.8±57.9%) and compatibility between the components, PLCL/PLGA 25/75 blend was selected for this application. Compact films were then surface modified via layer-by-layer (LbL) technique to enhance fibroblast cell response and confer antibacterial efficacy. A surface priming treatment (aminolysis) was optimized before depositing LbL coating. The following parameters were used: C=0.08 g/mL, t=8 min and T=37 °C. Then, multilayered chondroitin sulfate/chitosan (CHS/CH) coatings were deposited on the aminolysed films. The feasibility of multilayer coating was confirmed by QCM-D analysis. Further confirmations derived from water contact angle measurements (contact angle jumped alternatively between 45° and 65° depending on the outmost layer component) and FTIR-ATR analysis (appearance of absorbance peaks characteristics of CHS and CH). FTIC-labelled CH was also employed to follow LbL built up by fluorescence microscopy analysis. In vitro cell tests demonstrated the ability of coated samples to improve NIH 3T3 fibroblast adhesion and proliferation. Biocompatibility properties increased with increasing the layer number and were superior in the case of CH-terminating layers but no antibacterial activity was observed for films coated with 16 layers. Three dimensional sponge-like composite membranes fabricated by freeze-drying, with a composition similar to natural bone, and based on β-tricalcium phosphate (TCP) dispersed in a chitosan/gelatin (CH/G) network cross-linked with genipin (GP) and disodium phosphate salt (DSP) were developed as porous layer of the bi-layered device. Three membranes were developed (CH/G, CH/G+GP-DSP and CH/G/TCP+GP-DSP) and characterized. Successful double cross-linking of CH/G network was confirmed by Kaiser test, chemical and thermal analysis. All membranes showed a typical foam-like morphology with interconnected pores having an average diameter of 100-200 μm. Both cross-linking and TCP presence caused a marked increase of membrane stability in water solution, as well as of tensile modulus and maximum tensile strength (respectively, 14.9±5.1 MPa and 0.6±0.0 MPa for CH/G, and 29.4±2.7 MPa and 0.8±0.1 MPa for CH/G/TCP+GP-DSP.). Compared to CH/G samples, CH/G+GP-DSP and CH/G/TCP+GP-DSP membranes showed improved MG-63 human osteoblast-like cells response, in terms of cell viability and morphology. The assembly process of the compact and porous layer was developed based on the insertion of an intermediate adhesive layer composed by a polyvinylpyrrolidone/polyethylene glycol 70/30 wt/wt blend. Preliminary characterizations were carried out. Morphological analysis did not show changes in compact and porous layer structure due to the presence of the adhesive. The final device showed an elastic modulus of about 61 MPa in dry condition that markedly decreased in wet state (to about 5 MPa). Qualitative analysis of membrane manageability revealed its ability to adapt to mandible conformation after immersion in physiological solution. Despite the need for additional tests, the bi-layered membrane appeared promising for GTR/GBR applications.

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Gangolli, Riddhi Ajit. "A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/409954.

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Bioengineering
Ph.D.
60 % of school children have some form of untreated tooth decay or have suffered trauma to the front teeth which results in pulp damage. If left untreated, these teeth are susceptible to premature fracture/loss under daily stresses. In cases of adolescent tooth loss, teenagers cannot get dental implants until after the growth spurts; their only option is using removable dentures which lowers their quality of life. Conventional endodontic treatment (root canal treatment) is used in cases of pulp necrosis, but cannot be performed in immature permanent teeth due to major differences in tooth anatomy. Currently the American Dental Academy has approved a procedure called Regenerative Endodontic Treatment (RET) for such cases, but the outcomes are still unpredictable and the method is largely unreliable. One issue that we are trying to address in this work is the regeneration of the pulp-dentin complex (PDC), specifically the interface. Endeavors in regenerating either pulp or dentin have been successful individually, but the interface region is the anatomical and physiologic hallmark of the PDC and has not been addressed. We have proposed a biomimetic scaffold to facilitate early stage stratification of these different tissues and allow recapitulation of their interface. Tissue engineering principles and biomaterial processing techniques were used simultaneously to encourage dental pulp stem cells into mineralize selectively only on one side. This effectively allows the scaffold to serve as the interface region between the hard dentin and the soft vascular pulp.
Temple University--Theses

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Mayfield, Lisa. "Regeneration in periodontal and endosseous implant treatment." Malmö, Sweden : Dept. of Periodontology, Faculty of Odontology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39457632.html.

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Mizuno, Hirokazu, Hideaki Kagami, Junji Mase, Daiki Mizuno, and Minoru Ueda. "Efficacy of Membranous Cultured Periosteum for the Treatment of Patients with Severe Periodontitis: a Proof-of-Concept Study." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/12910.

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Moore, Edward Andrew. "Cell attachment and spreading on physical barriers used in periodontal guided tissue regeneration /." Oklahoma City : [s.n.], 2002. http://library.ouhsc.edu/epub/theses/Moore-William-A.pdf.

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Kolambkar, Yash Manohar. "Electrospun nanofiber meshes for the functional repair of bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37196.

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Bone defects caused by trauma, tumor resection or disease present a significant clinical problem. Failures in 'high risk' fractures and large bone defects have been reported to be as high as 30-50%. The drawbacks associated with current bone grafting procedures have stimulated the search for improved techniques for bone repair. Tissue engineering/regenerative medicine approaches promote tissue repair by providing a combination of physical and biological cues through structural scaffolds and bioactive agents. Though they have demonstrated significant promise for bone regeneration, very little has been translated to clinical practice. The goal of this thesis was to investigate the potential of electrospun nanofiber mesh scaffolds for bone regeneration. Nanofiber meshes were utilized in a three-pronged approach. First, we validated their ability to robustly support osteogenic cell functions, including proliferation and matrix mineralization. We also demonstrated their efficacy as a cell delivery vehicle. Second, we investigated the effects of modulating nanofiber bioactivity and orientation on stem cell programming. Our results indicate that functionalization of nanofiber meshes with a collagen-mimetic peptide enhanced the migration, proliferation and osteogenic differentiation of cells. Fiber alignment improved cell migration along the direction of fiber orientation. Finally, a nanofiber mesh based hybrid system for growth factor delivery was developed for bone repair and tested in a challenging animal model. The delivery of bone morphogenetic protein (BMP) via this system resulted in the functional restoration of limb function, and in fact proved more efficacious than the current clinical standard for BMP delivery. The studies performed in this thesis have suggested novel techniques for improving the repair of clinically challenging bone defects. They indicate that the delivery of BMP via the hybrid system may reduce the dose and side effects of BMP, thereby broadening the use of BMP based bone augmentation procedures. Therefore, this nanofiber mesh based system has the potential to become the standard of care for clinically challenging bone defects, including large bone defects, open tibial fractures, and nonunions.

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VerÃssimo, Denusa Moreira. "AvaliaÃÃo da biocompatibilidade e bioatividade de membranas colÃgeno polianiÃnico mineralizadas e reticuladas em modelos animais." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7934.

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nÃo hÃ
O objetivo desse estudo foi avaliar membranas de colÃgeno polianiÃnico (CPA) reticuladas e impregnadas com hidroxiapatita, manufaturadas pelo Departamento de FÃsica da Universidade Federal do CearÃ. Dividiu-se o trabalho em 2 etapas, onde inicialmente avaliou-se a biocompatibilidade e a biodegradaÃÃo de 6 diferentes membranas de CPA, divididas nos seguintes grupos: trÃs com 0, 25 e 75 ciclos de impregnaÃÃo com hidroxiapatita (CPA, CPA 25, CPA 75) e mais trÃs cujas membranas foram reticuladas com glutaraldeÃdo (GA) (CPA GA, CPA 25GA, CPA 75GA) inseridas em tecido subcutÃneo de ratos. AnÃlises histopatolÃgicas do infiltrado inflamatÃrio, atividade de mieloperoxidase (MPO), dosagem de citocinas, espessura de cÃpsula fibrosa, imunohistoquÃmica para metaloproteinase e biodegradaÃÃo das membranas foram avaliadas apÃs 1, 7, 15, 30, 60 e 120 dias. Posteriormente, avaliou-se o efeito das 3 melhores membranas na regeneraÃÃo Ãssea guiada usando defeito Ãsseo crÃtico em calvÃria de ratos (DOC), onde as membranas foram posicionadas sobre o defeito. FormaÃÃo Ãssea foi avaliada com base na radiografia digital (RD), tomografia computadorizada (TC) e anÃlise histolÃgica, 24 horas, 4, 8 e 12 semanas apÃs o procedimento cirÃrgico. MPO e dosagem de citocinas foram realizadas apÃs 24 horas. No subcutÃneo, as membranas reticuladas com GA mostraram espessa cÃpsula fibrosa e menor reaÃÃo inflamatÃria permanecendo intactas apÃs 120 dias. No modelo de regeneraÃÃo Ãssea em calvÃria de ratos, apÃs 12 semanas, os grupos CPA GA e CPA 25GA apresentaram reduÃÃo significativa da Ãrea radiolÃcida quando comparadas ao grupo basal. A anÃlise histolÃgica mostrou que nos grupos CPA GA e CPA 25GA as membranas ainda estavam intactas, envolvidas por uma espessa cÃpsula fibrosa e as membranas do grupo CPA 75GA apresentaram inÃcio de reabsorÃÃo. NÃo foi encontrada diferenÃa estatÃstica entre os grupos quanto a atividade MPO e citocina IL-1β. ConcluÃmos que as membranas reticuladas mostraram-se mais biocompatÃveis e se mantiveram livre de biodegradaÃÃo no perÃodo de observaÃÃo. Essas membranas induziram o fechamento dos defeitos Ãsseos e nÃo induziram reaÃÃo inflamatÃria. A impregnaÃÃo de hidroxiapatita nÃo acelerou a cicatrizaÃÃo do defeito cirÃrgico. Nossos resultados sugerem que as membranas de CPA reticuladas poderÃo ser Ãteis nos processos em que a formaÃÃo de um novo osso depende de uma duraÃÃo mais prolongada da barreira mecÃnica.
The aim of this study was to evaluate polyanionic collagen (PAC) membranes reticulated and impregnated with hydroxyapatite, manufactured by the Physics Department, Federal University of CearÃ. This study was divided into two stages, initially it was evaluated the biocompatibility and biodegradation of six different membranes of PAC, divided into the following groups: three with 0, 25 and 75 cycles of impregnation with apatite (PAC, PAC 25, PAC 75 ) and three more whose membranes were crosslinked with glutaraldehyde (GA) (GA PAC, PAC 25GA, PAC 75GA) inserted into the subcutaneous tissue of rats. Histopathological analyzes of inflammatory infiltration, myeloperoxidase activity (MPO), cytokine, thickness of fibrous capsule, immunohistochemistry for metalloproteinase and degradation of the membranes were evaluated after 1, 7, 15, 30, 60 and 120 days. Subsequently, it was evaluated the effect of the three best membranes in guided bone regeneration using bone critical defects in rat calvaria (DOC), where the membranes were placed over the defect. Bone formation was evaluated based on digital radiography (DR), computed tomography (CT) and histological analysis, 24 hours, 4, 8 and 12 weeks after surgery. MPO and cytokine were performed after 24 hours. In the subcutaneous tissue, the membranes crosslinked with GA showed thick fibrous capsule, less inflammatory reaction and remained intact after 120 days. In the bone regeneration model in rat calvaria, after 12 weeks, PAC GA and PAC 25GA groups showed significant reduction in radiolucent area compared to the baseline group. Histological analysis showed that in PAC GA and PAC 25GA groups, membranes were still intact, surrounded by a thick fibrous capsule and in PAC 75GA group, membranes showed early resorption. There was no statistical difference between groups in MPO activity and IL-1β. We conclude that the crosslinked membranes were more biocompatible and remained free from degradation during the observation period. These membranes induced closure of bone defects and did not induce inflammatory reaction. The impregnation of hydroxyapatite did not accelerate the healing of surgical defect. Our results suggest that the crosslinked membranes CPA may be useful in cases where new bone formation is dependent on a longer duration of mechanical barrier.

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Books on the topic "Guided Tissue Regeneration"

1

Hoffman, Lloyd S. Guided tissue regeneration. [Toronto: Faculty of Dentistry, University of Toronto], 1989.

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Gottlow, Jan. New attachment formation by guided tissue regeneration. Göteborg, Sweden: University of Göteborg, Faculty of Odontology, Dept. of Periodontology, 1986.

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Stocum, David L. Regenerative Biology and Medicine. Burlington: Elsevier, 2006.

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Anders, Hugoson, Lundgren Dan, Lindgren Birgitta, and Institute for Postgraduate Dental Education (Jönköping, Sweden), eds. Guided periodontal tissue regeneration: Factors significant for the predictability of a successful treatment result. Stockholm, Sweden: Förlagshuset Gothia, 1995.

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Bogdanowicz, Danielle R. Designing the Stem Cell Microenvironment for Guided Connective Tissue Regeneration. [New York, N.Y.?]: [publisher not identified], 2017.

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Daniel, Buser, ed. 20 years of guided bone regeneration in implant dentistry. 2nd ed. Hanover Park, IL: Quintessence Pub. Co., 2009.

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Krishan, Awtar. Applications of flow cytometry in stem cell research and tissue regeneration. Hoboken, N.J: John Wiley & Sons, 2010.

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Calandrelli, Luigi. Biodegradable composites for bone regeneration. New York: Nova Science Publishers, 2010.

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Raigrodski, Ariel J. Soft tissue management: The restorative perspective : putting concepts into practice. Chicago: Quintessence Publishing Co, Inc., 2015.

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Calandrelli, Luigi. Biodegradable composites for bone regeneration. Hauppauge, N.Y: Nova Science Publishers, 2009.

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Book chapters on the topic "Guided Tissue Regeneration"

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Dibart, Serge. "Guided Tissue Regeneration." In Practical Periodontal Plastic Surgery, 65–68. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119014775.ch11.

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Dumitrescu, Alexandrina L. "Guided Tissue Regeneration Barriers." In Chemicals in Surgical Periodontal Therapy, 1–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18225-9_1.

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Guess, Garrett, and Samuel Kratchman. "Guided Tissue Regeneration in Endodontic Microsurgery." In Microsurgery in Endodontics, 193–203. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119412502.ch19.

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Niemiec, Brook A., and Robert Furman. "Osseous Surgery and Guided Tissue Regeneration." In Veterinary Periodontology, 254–88. West Sussex, UK: John Wiley & Sons, Inc,., 2013. http://dx.doi.org/10.1002/9781118705018.ch18.

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Adelöw, Catharina A. M., and Peter Frey. "Synthetic Hydrogel Matrices for Guided Bladder Tissue Regeneration." In Methods in Molecular Medicine™, 125–40. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-443-8_7.

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Lin, Louis M., Domenico Ricucci, and Thomas von Arx. "Guided Tissue Regeneration in Endodontic Surgery: Principle, Efficacy, and Complications." In Complications in Endodontic Surgery, 177–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54218-3_16.

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Cortez, P. P., Yuki Shirosaki, C. M. Botelho, M. J. Simões, F. Gartner, R. M. Gil da Costa, Kanji Tsuru, et al. "Hybrid Chitosan Membranes Tested in Sheep for Guided Tissue Regeneration." In Bioceramics 20, 1265–68. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.1265.

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Chou, Chung-Hsing, Francesca Nicholls, and Michel Modo. "Image-Guided Injection and Noninvasive Monitoring of Tissue Regeneration in the Stroke-Damaged Brain." In Cell-Based Therapies in Stroke, 93–104. Vienna: Springer Vienna, 2012. http://dx.doi.org/10.1007/978-3-7091-1175-8_7.

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Ku, Ha Ra, Hyun Seon Jang, S. G. Kim, Moon Jin Jeong, Joo Cheol Park, Heung Joong Kim, Young Sun Kwon, Chong Kwan Kim, and Byung Ock Kim. "Guided Tissue Regeneration of the Mixture of Human Tooth-Ash and Plaster of Paris in Dogs." In Key Engineering Materials, 1327–30. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-422-7.1327.

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Shin, Young Min, Hee Seok Yang, and Heung Jae Chun. "Directional Cell Migration Guide for Improved Tissue Regeneration." In Advances in Experimental Medicine and Biology, 131–40. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3258-0_9.

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Conference papers on the topic "Guided Tissue Regeneration"

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Setyawati, Ernie Maduratna, and Nahdhiya Amalia Puspita Klana. "Concise review: Periodontal tissue regeneration using pericardium membrane as guided bone regeneration." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0036635.

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Shyh Ming Kuo, Shwu Jen Chang, Yun Ting Hsu, and Ta Wei Chen. "Evaluation of Alginate coated Chitosan Membrane for Guided Tissue Regeneration." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1615565.

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Widiyanti, Prihartini, and Mohammad Bagus Lazuardi. "Biological evaluation of PCL-AgNPs biocomposites as guided tissue regeneration membranes." In 5TH INTERNATIONAL CONFERENCE ON ELECTRICAL, ELECTRONIC, COMMUNICATION AND CONTROL ENGINEERING (ICEECC 2021). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0136920.

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Ishii, Katsunori, Zhenhe Ma, Yoshihisa Ninomiya, Minori Takegoshi, Toshihiro Kushibiki, Masaya Yamamoto, Monica Hinds, Yasuhiko Tabata, Ruikang K. Wang, and Kunio Awazu. "Control of guided hard-tissue regeneration using phosphorylated gelatin and OCT imaging of calcification." In Biomedical Optics (BiOS) 2007, edited by Sean J. Kirkpatrick and Ruikang K. Wang. SPIE, 2007. http://dx.doi.org/10.1117/12.701485.

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Rossmann, Jeffrey A., Ates Parlar, Khaled A. Abdel-Ghaffar, Amr M. El-Khouli, and Michael Israel. "Use of the carbon dioxide laser in guided tissue regeneration wound healing in the beagle dog." In Photonics West '96, edited by Harvey A. Wigdor, John D. B. Featherstone, Joel M. White, and Joseph Neev. SPIE, 1996. http://dx.doi.org/10.1117/12.238753.

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Krishnamoorthy, Srikumar, and Changxue Xu. "Fabrication of a Graded Micropillar Surface for Guided Cell Migration." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8332.

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Abstract The migration of cells is caused by the interaction of cells and the local microenvironment around them, such as changes in stiffness, chemical gradients etc. The local topography of substrates in contact with cells is a key factor that regulates the migration of cells. The interaction between the topography of the substrate and cells is crucial for the understanding of tissue development and regeneration. In this paper, the fabrication of a graded micropillar substrate for studying topography-based cell migration is described in detail. The fabrication protocol comprises of the utilization of dynamic maskless lithography system, capillary molding, and corona arc surface treatment. The fabricated micropillar substrate has been shown and the cells have been successfully seeded on the substrate. Guided cell migration on the substrate with graded microtopography has been demonstrated to occur from the sparser zone to the denser zone. Moreover, some examples of potential applications are provided.

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Cheng, Yu-Chen, and Pen-Hsiu Grace Chao. "A Model for Ligament Fibroblast Migration Into Provisional Matrix." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53858.

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Many strategies have been proposed to enhance the healing capability of the anterior cruciate ligament (ACL). A novel treatment option, called enhanced primary repair, places a provisional matrix at the tear site to promote cell infiltration of the wound and aims to reestablish the structure-function relationship of the ACL [1]. This approach of guided tissue regeneration offers great potential benefits of retaining the complex native tissue matrix structure, innervation, and vascularization as compared with grafts. A major aspect of this procedure is enhancing ligament fibroblast infiltration into the matrix material and promoting matrix synthesis. We have previously demonstrated that applied electric fields (EFs) enhance knee ligament fibroblast migration, alignment, and collagen gene expressions on planar substrates [2]. In the current study, we developed a new system to simulate cell infiltration from the tissue to a provisional collagen matrix. An EF was applied across the construct to investigate its effects of on ACL fibroblast migration into the provisional matrix.

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Yang, Yueh-Hsun, and Gilda A. Barabino. "Interrupted Treatment With Growth Factors in Combination With Hydrodynamic Forces Enhances ECM Deposition in Tissue-Engineered Cartilage." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53282.

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Achievement of viable engineered tissues through in-vitro cultivation in bioreactor systems requires a thorough understanding of the complex interplay between mechanical forces and biochemical cues. Briefly, bioreactors have been employed to impart mechanical stimuli to support tissue growth and development. Continuous fluid-induced shear stress, for example, has been shown to influence morphology and properties of engineered cartilage.1 Fluid flow enhances mass transfer mechanisms and simultaneously provides mechanical stimuli across or through the construct to emulate shear forces that occur in the knee or other joints. Critical biochemical factors, such as growth factors, are secreted by cells2,3 and involved in cell-to-cell signaling. Guided by these molecules, cells can communicate with each other and work synergistically to accomplish a specific task. It has also been demonstrated that the pathways of certain growth factors, such as transforming growth factor-β (TGF-β) family and insulin-like growth factor-1 (IGF-1), are responsive to shear stress, resulting in enhanced cell and tissue activities, and their expression is also up-regulated by fluid-induced shear stress.4,5 This evidence suggests their involvement in mechanotransduction mechanisms. However, a combination of mechanical and biochemical stimuli results in a complex culture environment which is not yet fully characterized. The present study was designed to obtain an understanding of the combined effects of hydrodynamic forces and growth factors on cartilage regeneration by employing a custom-designed wavy-walled bioreactor1 (WWB) and by selecting IGF-1 and TGF-β1 as two model molecules. We hypothesized that bioprocessing conditions which optimize mechanical, biochemical and compositional properties of tissue-engineered cartilage can be achieved under hydrodynamic stimuli in combination with an appropriate use of IGF-1 or TGF-β.

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Wettergreen, M., B. Bucklen, B. Starly, E. Yuksel, W. Sun, and M. A. K. Liebschner. "Unit Block Library of Basic Architectures for Use in Computer-Aided Tissue Engineering of Bone Replacement Scaffolds." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81984.

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Guided tissue regeneration focuses on the implantation of a scaffold architecture, which acts as a conduit for stimulated tissue growth. Successful scaffolds must fulfill three basic requirements: provide architecture conducive to cell attachment, support adequate fluid perfusion, and provide mechanical stability during healing and degradation. The first two of these concerns have been addressed successfully with standard scaffold fabrication techniques. In instances where load bearing implants are required, such as in treatment of the spine and long bones, application of these normal design criteria is not always feasible. The scaffold may support tissue invasion and fluid perfusion but with insufficient mechanical stability, likely collapsing after implantation as a result of the contradictory nature of the design factors involved. Addressing mechanical stability of a resorbable implant requires specific control over the scaffold design. With design and manufacturing advancements, such as rapid prototyping and other fabrication methods, research has shifted towards the optimization of scaffolds with both global mechanical properties matching native tissue, and micro-structural dimensions tailored to a site-specific defect. While previous research has demonstrated the ability to create architectures of repetitious microstructures and characterize them, the ideal implant is one that would readily be assembled in series or parallel, each location corresponding to specific mechanical and perfusion properties. The goal of this study was to design a library of implantable micro-structures (unit blocks) which may be combined piecewise, and seamlessly integrated, according to their mechanical function. Once a library of micro-structures is created, a material may be selected through interpolation to obtain the desired mechanical properties and porosity. Our study incorporated a linear, isotropic, finite element analysis on a series of various micro-structures to determine their material properties over a wide range of porosities. Furthermore, an analysis of the stress profile throughout the unit blocks was conducted to investigate the effect of the spatial distribution of the building material. Computer Aided Design (CAD) and Finite Element Analysis (FEA) hybridized with manufacturing techniques such as Solid Freeform Fabrication (SFF), is hypothesized to allow for virtual design, characterization, and production of scaffolds optimized for tissue replacement. This procedure will allow a tissue engineering approach to focus solely on the role of architectural selection by combining symmetric scaffold micro-structures in an anti-symmetric or anisotropic manner as needed. The methodology is discussed in the sphere of bone regeneration, and examples of cataloged shapes are presented. Similar principles may apply for other organs as well.

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Unrau, Bernard. "GT (Guided Tissue Regeneration) Incorporating a Modified Microgravity Surgical Chamber and Kavo-3-Mini Unit for the Treatment of Advanced Periodontal Disease Encountered in Extended Space Missions." In International Conference On Environmental Systems. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1991. http://dx.doi.org/10.4271/911337.

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Reports on the topic "Guided Tissue Regeneration"

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Cotillo, Luis, Antony Tello, Patricia Horna, Andrea Lopez, and Marco Alarcon. Efficacy of the enamel matrix derivative in guided tissue regeneration with bone substitutes in intraosseous periodontal defects: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2024. http://dx.doi.org/10.37766/inplasy2024.2.0008.

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