Academic literature on the topic 'Granuloma'
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Journal articles on the topic "Granuloma"
Mattila, Joshua T., Victoria A. Gould, Beth A. Junecko, Michael C. Bellavia, H. Jacob Borish, Alexander G. White, Pauline Maiello, et al. "Bacteria load and hypoxia contribute to glucose uptake by macrophages and T cells in cynomolgus macaque granulomas." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 50.22. http://dx.doi.org/10.4049/jimmunol.208.supp.50.22.
Full textCardoso, Marcos S., Tânia M. Silva, Mariana Resende, Rui Appelberg, and Margarida Borges. "Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas." Infection and Immunity 83, no. 9 (June 22, 2015): 3534–44. http://dx.doi.org/10.1128/iai.00144-15.
Full textHogan, Laura H., Wes Markofski, Anja Bock, Brittany Barger, James D. Morrissey, and Matyas Sandor. "Mycobacterium bovis BCG-Induced Granuloma Formation Depends on Gamma Interferon and CD40 Ligand but Does Not Require CD28." Infection and Immunity 69, no. 4 (April 1, 2001): 2596–603. http://dx.doi.org/10.1128/iai.69.4.2596-2603.2001.
Full textFitzgerald, Liam E., Naiara Abendaño, Ramon A. Juste, and Marta Alonso-Hearn. "Three-DimensionalIn VitroModels of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/623856.
Full textRumbley, Catherine A., S. Ali Zekavat, Hiroko Sugaya, Peter J. Perrin, Mohamad Ali Ramadan, and S. Michael Phillips. "The Schistosome Granuloma: Characterization of Lymphocyte Migration, Activation, and Cytokine Production." Journal of Immunology 161, no. 8 (October 15, 1998): 4129–37. http://dx.doi.org/10.4049/jimmunol.161.8.4129.
Full textHerbath, Melinda, Jeffrey S. Harding, Sarah Marcus, George Hasko, Andras Nagy, Zsuzsanna Fabry, and Matyas Sandor. "Regulators of mycobacterial granuloma formation – CCL2 and VEGF-A." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 42.7. http://dx.doi.org/10.4049/jimmunol.200.supp.42.7.
Full textDhakal, Mona, Om Prakash Dhakal, Mingma Sherpa, Amlan Gupta, and Dhurba Bhandari. "Large gastric ulcer: Result of foreign body-induced giant cell reaction." Journal of Digestive Endoscopy 04, no. 03 (July 2013): 078–81. http://dx.doi.org/10.4103/0976-5042.129974.
Full textMetwali, A., D. Elliott, R. Mathew, A. Blum, and J. V. Weinstock. "IL-2 contributes to the IL-5 response in granulomas from mice infected with Schistosoma mansoni." Journal of Immunology 150, no. 2 (January 15, 1993): 536–42. http://dx.doi.org/10.4049/jimmunol.150.2.536.
Full textTalita Shofa Adestia. "In vitro Tuberculosis Granuloma Model in M. tuberculosis H37Rv." Jurnal Biosains Pascasarjana 25, no. 1 (June 30, 2023): 66–73. http://dx.doi.org/10.20473/jbp.v25i1.2023.66-73.
Full textRakasz, Eva, Arthur M. Blum, Ahmed Metwali, David E. Elliott, Jie Li, Zuhair K. Ballas, Khurram Qadir, Richard Lynch, and Joel V. Weinstock. "Localization and Regulation of IFN-γ Production Within the Granulomas of Murine Schistosomiasis in IL-4-Deficient and Control Mice." Journal of Immunology 160, no. 10 (May 15, 1998): 4994–99. http://dx.doi.org/10.4049/jimmunol.160.10.4994.
Full textDissertations / Theses on the topic "Granuloma"
Rimoli, Caroline Fernandes [UNESP]. "Tratamento de granulomas laríngeos decorrentes de intubação endotraqueal: revisão sistemática e metanálise proporcional." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/147991.
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Introdução: os granulomas laríngeos são lesões benignas, não neoplásicas, uni ou bilaterais, de etiologia variável, que ocorrem no terço posterior das pregas vocais ou na região aritenoídea. Os sintomas são diversos, sendo o mais comum a rouquidão. Os granulomas decorrentes de intubação são altamente recidivantes e não existe consenso quanto ao melhor tratamento. Objetivo: comparar a efetividade dos tratamentos dos granulomas laríngeos decorrentes de intubação endotraqueal. Métodos: foram realizadas revisão sistemática e metanálise proporcional de estudos sobre o tratamento de granulomas laríngeos decorrentes de intubação endotraqueal, seja ele primário ou recidivante. Os critérios de elegibilidade foram: ensaios clínicos randomizados e estudos prospectivos controlados, e na ausência destes, aceitos também estudos retrospectivos e prospectivos não controlados com no mínimo cinco participantes. Os desfechos estudados foram resolução, recidiva e tempo para resolução do granuloma. Os estudos foram identificados na base de dados Pubmed, Embase, Lilacs e Cochrane. Para a análise dos dados e metanálise, utilizou-se o programa StatsDirect 3.0.121. Resultados: dentre os 578 artigos encontrados, 61 foram lidos na íntegra e seis selecionados para a revisão, totalizando 85 pacientes, com idade variando de 21 a 86 anos. Os tratamentos encontrados foram: antirrefluxo, fonoterapia, anti-inflamatórios, corticoterapia, antibioticoterapia, sulfato de zinco e cirurgia. Para o tratamento primário, foram estudados 85 pacientes, de seis estudos, divididos em dois grupos: cirúrgico ± associações (41 pacientes), com chance de resolução de 75% (IC 95%: 0,3% a 100%, I2= 90%), e risco absoluto de recidiva de 25% (IC 95%: 0,2% a 71%), e clínico (44 pacientes), com chance de resolução de 86% (IC 95%: 67% a 97%), e risco absoluto de recidiva de 14% (IC 95%: 3% a 33%). Na interpretação da metanálise, não houve diferença estatisticamente significativa entre os grupos, já que houve sobreposição dos intervalos de confiança. Três estudos, englobando 19 pacientes, estudaram o tratamento secundário (quando houve insucesso ou recidiva após o tratamento primário), sendo que três indivíduos apresentaram nova recidiva. O tempo de tratamento necessário para a resolução das lesões variou muito, desde imediato, como após as cirurgias, como até 23 meses, no caso do corticosteroide inalatório (budesonida). O sulfato de zinco levou um tempo de quatro a 12 semanas. O tratamento antirrefluxo não teve um tempo bem especificado em todos os estudos. Conclusão: não identificamos diferença estatisticamente significativa entre as modalidades de tratamento para os granulomas de intubação. Certamente, esse resultado foi influenciado pela falta de estudos mais abrangentes e criteriosos, principalmente ensaios clínicos, e também pelo número reduzido de pacientes em cada estudo. O tratamento que apresentou menor tempo médio para resolução do granuloma foi o cirúrgico, e o maior, corticosteroide (budesonida) inalatório.
Introduction: laryngeal granulomas are benign, non-neoplastic lesions that can occur unilaterally or bilaterally for various causes. They are usually located in the posterior third of the vocal folds or in the arytenoid region. Patients may present a number of symptoms, the main one being hoarseness. Post-intubation granulomas are highly recurrent and there is no consensus on the best treatment. Objective: to compare the effectiveness of treatments of laryngeal granulomas secondary to endotracheal intubation. Methods: systematic review and proportion meta-analysis of studies that address the treatment of laryngeal granulomas caused by endotracheal intubation. The eligibility criteria were: randomized controlled trials and controlled prospective studies, and in the absence of these, retrospective and prospective uncontrolled studies were also accepted, with at least five participants. The outcomes that were measured were resolution, recurrence and time to resolve the granuloma. Databases searched were Pubmed, Embase, Lilacs and Cochrane. Statistical analysis was performed with the StatsDirect version 3.0.121 software. Results: among the 578 articles found, 61 were eligible for full reading and 11 articles were included, involving 85 patients, with ages varying from 21 to 86 years). The treatments were: anti-reflux, speech therapy, anti-inflammatory drugs, corticosteroids, antibiotics, zinc sulfate and surgery. For the primary treatment, 85 patients were investigated in six studies, divided into two groups: surgical ± associations (41 patients), with chance of resolution of 75% (95% CI: 0,3% to 100%, I2= 90%), and absolute risk of recurrence of 25% (95% CI: 0,2% to 71%) and clinical (44 patients), with chance of resolution of 86% (95% CI: 67% to 97%), and absolute risk of recurrence of 14% (95% CI: 3 to 33%). In the interpretation of the meta-analysis, there was no statistical significance between the groups, since there was an overlap of confidence intervals. Three studies involving 19 patients analyzed secondary treatment (when there was failure or recidive after primary treatment). Three patients had a new recurrence. The treatment time required for the resolution of the lesions varied greatly, from immediate, as after surgery, as up to 23 months, in the case of inhaled corticosteroid (budesonide). The zinc sulfate took a time of four to 12 weeks. The antireflux treatment did not have a well-specified time in all studies. Conclusion: we have not identified a statistical significance between the treatment modalities for intubation granulomas. Certainly, this result was influenced by the lack of more comprehensive and solid studies, particularly clinical trials, and also by the small number of patients in each study. The treatment that had the lowest mean time to resolve the granuloma was surgery, and the highest was inhaled corticosteroid (budesonide).
Sado, Ricardo Yuji. "Filogenia do processo inflamatório em animais ectotérmicos: estudo comparativo entre peixes teleósteos primitivos e modernos inoculados com BCG." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-08072005-095310/.
Full textThe aim of this study was the evaluation of the histological, imunohistochemical and ultra structural aspect of the inflammatory response experimentally induced by BCG intramuscular injection in phylogenetically primitive fishes of the genera Arius sp and modern of the genera Centropomus sp, with the purpose of establishing comparative parameters of the inflammatory response between modern and primitive fishes about phylogenetic aspect. The results show differences in the inflammatory response between modern and primitive fishes. Modern fishes have the ability of organization of the lesion, with development of tipical granulomas and epithelioid cells that produce S100 protein, cytokeratin and throughout the experiment they developed desmosomic junctions; instead of primitive fishes that don?t show the ability of organization of the lesion without forming an granuloma, just giant cells that produce S100 protein. It didn?t have an expressive participation of giant cells and pigmentcontaining cells in the inflammatory reaction in genera Centropomus sp, suggesting that It is a specie-specific characteristic, in opposition to some results found in modern fishes about pigment cells participation in the inflammatory reaction of modern fishes.
Fondati, Alessandra. "Pathogenetic studies on feline eosinophilic granuloma complex." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/3658.
Full textEn aquesta tesi, es varen estudiar els signes histopatològics de les diferents lesions clíniques del EGC amb seccions de H & E i tinció tricròmica. A H & E, totes les lesiones del EGC examinades es varen caracteritzar per un infiltrat dèrmic eosinofílic, de intensitat variable, i per la presència de petits a grans focus de material eosinofìlic que amb la tinció tricròmica, semblaren estar constituïts per fibres de col·lagen normals rodejades per restes de material amb el mateix aspecte tintorial dels grànuls dels eosinòfils. Aquests resultats indiquen que les lesiones del EGC amb diferent aspecte clínic histopatològicament són indistingibles i que els focus dèrmics de material eosinofílic, petits i grans, tenen una histogènesi similar. A més, les figures amb flama, utilitzades per definir petits focus de material eosinofílic amb analogia amb les figures amb flama de la síndrome de Wells, es poden utilitzar també per parlar de dipòsits de material eosinofílic de gran tamany.
A més, es va investigar la ultraestructura de les figures en flama, petites i grans, de les lesions del EGC. Estan formades per fibrilles de col·lagen morfològicament inalterades, fibres de col·lagen parcialment separades per edema i restes cel·lulars i eosinòfils desgranulats via ECL i PMD. La ultraestructura de les figures en flama al EGC va ser similar al que es descriu a les figures en flama de la síndrome de Wells humana. Això suggereix que en el gat els eosinòfils juguen un paper primari en la formació de les figures en flama, anàlogues a les descrites als humans. A més, aquest estudi demostra que al EGC felí, en els teixits, els eosinòfils alliberen el contingut dels seus grànuls per ECL i PMD, igual que els eosinòfils tisulars humans en inflamacions mediades per eosinòfils. El mecanisme de desgranulació predominant va ser ECL.
Es va realitzar un estudi ultraestructural de eosinòfils circulants de gats amb diferents recomptes de eosinòfils i diferents malalties asociades a eosinofília. Als eosinòfils perifèrics es va observar morfologia de PMD, indicativa d'activació i desgranulació. No es va observar correlació directa entre en numero de eosinòfils que presentaven canvis de PMD i el nivell de eosinofília sanguínia. Aquesta última observació suggereix que el recompte del número total de eosinofils circulants no representa el millor criteri per avaluar la participació dels eosinòfils en una malaltia eosinofílica.
Finalment, es va realitzar un estudi sobre les proteïnes dels grànuls dels eosinòfils del gat. Es varen estudiar les proteïnes dels grànuls extretes de eosinòfils obtinguts per inducció experimental de eosinofilia peritoneal. Les proteïnes es varen analitzar per cromatografia de gel-filtració i es varen estudiar les seves activitats biològiques. Les proteïnes dels grànuls dels eosinòfils del gat tenen activitats peroxidasa, RNasa i bactericida. La EAR felina presenta una homologia de la seqüència N-terminal amb les proteïnes de la superfamília de la RNasa A, incloses les RNases de eosinòfils i la seqüència N-terminal de la MBP felina va ser homòloga a la de la MBP-1 humana i murina. Aquest resultats indiquen que les proteïnes dels grànuls del eosinòfil felí tenen un paper biològic similar als descrits als humans i a altres espècies animals i evidencien que el gat pot ser una espècie adequada per l'estudi de les malalties eosinofíliques humanes.
Despite being commonly reported, feline eosinophil-associated disorders, including EGC, are poorly understood and generally associated to immune-mediated or parasitic causes, analogous to their human counterparts. Nevertheless, cat eosinophil functions and contents, although considered similar to those of human eosinophils, are currently unknown. Hence, the objectives of this thesis were to study feline EGC and to obtain specific information on the cat eosinophil biology.
In this thesis, the histopathological features of clinically different EGC lesions were studied on H & E and trichrome stained sections. With H & E stain, all the EGC lesions examined were characterised by a dermal eosinophilic infiltration of variable intensity and the presence of small- to large-sized foci of eosinophilic debris that, with trichrome stain, appeared to consist of normally stained collagen fibres surrounded by a debris showing the same tinctorial properties as eosinophil granules. These results showed that EGC lesions with different clinical appearance are histopathologically indistinguishable and that small- and large-sized dermal foci of eosinophilic debris have similar histogenesis. Hence, the term flame figures, normally used to define small foci of eosinophilic debris by analogy with flame figures in Wells' syndrome, may be employed also to designate large-sized focal depositions of this debris.
Furthermore, the ultrastructure of small- and large-sized flame figures in EGC lesions was investigated. They comprised morphologically unaltered collagen fibrils, collagen fibres partly disrupted by oedema and cellular debris, and degranulating eosinophils via ECL and PMD. The ultrastructure of flame figures in EGC was similar to that reported in flame figures of human Wells' syndrome. This suggested that eosinophils play a primary role in flame figures formation in cats, analogous to what reported in humans. In addition, this study demonstrated that tissue eosinophils in feline EGC release their granule contents by ECL and PMD, analogous to human tissue eosinophils at sites of eosinophil-mediated inflammation. ECL was the predominant mode of degranulation.
An ultrastructural study of feline circulating eosinophils from cats with various blood eosinophil counts and different eosinophil-associated diseases was also performed. PMD morphology, indicative of eosinophil activation and degranulation, was recognised in peripheral eosinophils. No direct correlation was found between the number of eosinophils showing PMD changes and the level of blood eosinophilia. This latter finding suggested that total blood eosinophil count might not represent the best criterion to evaluate the contribution of eosinophils to the ongoing eosinophil-associated disease.
Finally, a study on cat eosinophil granule proteins was conducted. Granule proteins, extracted from cat eosinophils obtained by experimentally induced peritoneal eosinophilia, were analysed by gel-filtration chromatography and their biological activities were studied. Cat eosinophil granule proteins possessed peroxidase, RNase and bactericidal activities. Feline EAR showed N-terminal sequence homology with proteins of the RNase A superfamily, including eosinophil RNases, and the N-terminal sequence of feline MBP was homologue to that of human and murine MBP-1. These findings indicated that feline eosinophil granule proteins have biological roles similar to those reported in humans and other animal species and highlighted that the cat might represent a suitable species for studying human eosinophil-mediated diseases.
Molina, Raphael Fagnani Sanchez. "Efeito de terapias na modulação do granuloma paracoccidioidomicótico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-12012011-094302/.
Full textParacoccidioidomycosis (PCM) is a systemic mycosis that is endemic in Latin America, whose causative agent is the thermal dimorphic fungus Paracoccidioides brasiliensis (Pb). PCM is a granulomatous disease, and the formation of granulomas can be understood as a mechanism of the body to block and limit the invasiveness of the fungus or its antigenic components, once unable to lyse them. Bening forms of the disease are characterized by a localized infection, where granulomasa are compact and contain few fungi. More severe forms present loose granulomatous processes with foci of necrosis and severe fungal. Studies in which granulomatous response was developed in resistant (A/J) and susceptible (B10.A) mice to the high virulence isolate Pb18 showed the presence of different patterns of injuries related to the type of extracellular matrix (ECM) components and the different cells types in the area, suggesting a important role of these elements in the formation and constitution of the granuloma and thus the outcome of infection. In our project, we aimed to evaluate the development of granulomatous lesions in the spleen, liver, lung and omentum of mice susceptible to PCM after intraperitoneal infection with Pb18, at different periods of infection (acute and chronic) with or without treatment with drugs. These drugs have mechanisms of action closely related to the change in the balance between synthesis and degradation of collagen Thus, they interfere directly in the granuloma formation and in maintaining the viability of fungi and also with the development of fibrosis. Which is a common and devastating sequelae of numerous infections including the PCM, with the characteristic proliferation of fibroblasts and deposition of ECM. The treatments were chosen based on prior knowledge on their effects on the course of experimental murine PCM. IFN-g was chosen due to its antifibrotic effect, being an activator of macrophages in infection by P. brasiliensis and increasing the fungicidal effect of neutrophils. The antibiotic tetracycline was used because of its inhibitory effect on the synthesis of extracellular matrix, limiting antimicrobial activity and the ability of collagenase to degrade ECM. Finally, the antiinflammatory drugs Celecoxib and Lumiracoxib (inhibitors of the COX-2 enzyme) 11 were used because they cause an increase in the expression of collagen type III and type IV. We analyzed the components of the granuloma (collagen, inflammatory cells, cytokines essential for synthesis / degradation of the ECM of the granuloma, the presence of P. brasiliensis). Among the cytokines analyzed, we studied the importance of TNF-α in the formation of granulomas and regulation of matrix metalloproteinases (MMP) synthesis and function. We analyzed TGF-b because it negatively modulate the secretion of nitric oxide by macrophages and promote the accumulation of ECM and is believed to be the central mediator of the process of fibrosis in several pathologies. IFN-g was studied because of its correlation to the preferential Th1 immune response in diseases and infectious processes of fungal and bacterial infections, and also because it modulates fibroblast function.
Oliveira, Anita Santos de. "O complexo Mycobacterium avium: caracterização e patogenicidade." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5176.
Full textAs infeções provocadas por micobactérias são das doenças mais antigas que afetam a humanidade, estando descritas há mais de 4000 anos. As micobactérias ditas atípicas (NTM - "non-tuberculous mycobacteria"), nomeadamente as pertencentes ao complexo Mycobacterium avium (MAC), são ubíquas no meio ambiente, sendo impossível evitar a exposição ambiental. Estas bactérias são ingeridas através da água e alimentos, mas também inaladas através de aerossóis. Assim, uma grande parte da população já teve contato com MAC, mas nunca desenvolveu doença. O interesse pelas doenças provocadas por NTM cresceu exponencialmente com o recrudescimento global da epidemia da SIDA, pois muitas são patogénicos oportunistas. A infeção pulmonar é a forma de apresentação mais comum do MAC, mas também pode ocorrer infeção disseminada. De modo a evitar o desenvolvimento de doença oportunista recomenda-se o uso de profilaxia. A difícil eliminação do MAC pelos hospedeiros susceptíveis leva à sua permanência no interior das células fagocíticas e acaba por conduzir à formação de granuloma pulmonar. O diagnóstico diferencial baseia-se em métodos fenotípicos e genéticos. Relativamente ao tratamento, devido à sua camada exterior lipofílica, os medicamentos hidrofílicos apresentam fraca penetração. A terapia habitual utiliza uma combinação de antibióticos, para prevenir o surgimento de resistências. Infections caused by mycobacteria are of the oldest diseases affecting humanity, being described and researched about for over 4000 years. The atypical mycobacteria (NTM - "non-tuberculous mycobacteria"), in particular those belonging to the Mycobacterium avium complex (MAC), are ubiquitous in the environment, thus making it impossbile to avoid environmental exposure. These bacteria are ingested through water and foods but also through inhaled aerosols. Therefore, a large part of the population has had contact with MAC, but never developed any associated diseases. Interest in diseases caused by NTM has grown exponentially with the global resurgence of the AIDS epidemic, because many are opportunistic pathogens. Pulmonary infection is the most common form of presentation of the MAC, but can also be seen as a disseminated infection. To prevent the development of opportunistic infection it is recommended to use prophylaxis. The difficult elimination of susceptible hosts by MAC results in them staying permanently within the phagocytic cells and ultimately leads to the formation of pulmonary granuloms. Differential diagnosis is based on phenotypic and genetic methods. For the treatment, due to its lipophilic outer layer, hydrophilic drugs have poor penetration. The usual therapy uses a combination of antibiotics, to prevent emergence of resistance.
Grenå, Madeleine, and Beata Gill. "Gastrostomi : Granulombehandling vid gastrostomi hos barn och ungdomar." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165806.
Full textAim. The aim of the study was to investigate the occurrence and treatment of granulomas in children and adolescents under the age of 18 with gastrostomy in Sweden. The aim was also to investigate nurses knowledge of granulomatreatment in children and adolescents under the age of 18 with gastrostomy in Sweden. Methods. The design was of quantitative method by questionnaire. A questionnaire was sent to nurses who work in Sweden and are included in one of the following networks: Network for rehabilitation nurses, Network for rehabilitation nurses in nutrition and / or Network for nutrition nurses. Results. The severity of granuloma varied, depending on the child's general health. 52% estimated that the children developed granulomas within two months after insertion of the gastrostomy. 34% of respondents estimated that about 25% of children and adolescents with gastrostomier develop granulomas.46% used a combination of lapis and cortisone ointment as a treatment for granuloma. Conclusion.The treatments currently used for granulomas is lapis and cortisone ointment, these are used by many in combination with each other and seem to have a good result. Nurses' knowledge in the field is extensive and many have a common view that granuloma formation is often linked to the patients general health.
Clay, Hilary. "Early host-pathogen interactions during mycobacterial infection of zebrafish embryos /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5033.
Full textSignoretti, Fernanda Graziela Correa 1979. "Avaliação microbiológica de lesões periapicais crônicas associadas ao insucesso do retratamento endodôntico." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288785.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O conhecimento do perfil microbiano envolvido na periodontite apical persistente pode auxiliar no estabelecimento de protocolos mais eficazes na conduta endodôntica. Através de um relato de caso clínico e da avaliação de 20 casos de periodontite apical persistente após retratamento endodôntico, foram objetivos deste trabalho: identificar bactérias viáveis em lesões periapicais persistentes e correlacionar os achados microbiológicos com o diagnóstico histopatológico da lesão. Métodos: No relato de caso o dente foi submetido ao retratamento endodôntico através da técnica de crown-down com o uso de substância química auxiliar (clorexidina 2% gel), patência e alargamento foraminal e obturação dos canais em sessão única. Após persistência da fístula foi indicada apicectomia, que foi realizada sob magnificação e retro-obturação com MTA. O fragmento apical da raiz distal foi observado por microscopia eletrônica de varredura e foi realizada cultura microbiana da lesão curetada (capítulo 1). Foram selecionados 20 pacientes com necessidade de cirurgia parendodôntica, submetidos à coleta durante a curetagem do tecido periapical. As amostras foram processadas microbiologicamente por técnicas de cultura microbiana e enviadas para diagnóstico histológico (capítulo 2). Resultados: No capítulo 1 as seguintes espécies foram encontradas: Actinomyces naeslundii e Actinomyces meyeri, Propionibacterium propionicum, Clostridium botullinum, Parvimonas micra e Bacteroides ureolyticus; a análise em microscopia eletrônica de varredura revelou biofilme bacteriano circundante ao forame apical e superfície radicular externa. O trespasse de guta-percha no zip apical causado durante o primeiro tratamento também foi observado. A proservação radiográfica após seis meses mostrou reparo periapical aparente, o qual foi confirmado após 24 meses. No capítulo 2 foram encontrados mais cistos (13/20) do que granulomas (7/20). A cultura microbiológica e testes bioquímicos específicos puderam identificar 83 bactérias cultiváveis divididas em 33 espécies bacterianas distintas. As lesões demonstraram uma infecção de caráter misto, composta em sua maior parte por microrganismos anaeróbios estritos (80,4% em cistos e 65% em granulomas) e Gram-positivos (70,6% em cistos e 84,4% em granulomas). Embora se tenha isolado até sete espécies bacterianas em uma única lesão (granuloma), na maioria dos casos, quatro (25%) ou cinco (35%) espécies foram encontradas simultaneamente. Os dados foram analisados estatisticamente através do teste exato de Fisher e chi-quadrado de Pearson (P<.05). Conclusões: Bactérias Gram-positivas anaeróbias estritas e o biofilme extrarradicular parecem participar da etiologia do insucesso do tratamento endodôntico. O retratamento endodôntico seguido de microcirurgia periapical constitui uma alternativa de sucesso na resolução de infecções extrarradiculares persistentes (capítulo 1). Embora os cistos tenham sido mais frequentes que granulomas nos casos de insucesso do retratamento endodôntico, bactérias foram isoladas em ambos os tipos de lesão, com uma predominância de espécies gram-positivas, sugerindo que as mesmas são capazes de sobreviver fora do canal radicular e podem estar relacionadas com a persistência do processo patológico, mesmo após um retratamento endodôntico acurado (capítulo 2)
Abstract: The knowledge of the microbial profile of persistent apical periodontitis allows the development of more efficient endodontic therapy. Through the evaluation of a case report and 20 cases of persistent apical periodontitis after endodontic retreatment, the objectives of this study were: to identify viable bacteria in persistent periapical lesions and correlate microbiological findings with histopathological diagnosis. Methods: In the case report, the tooth had undergone endodontic retreatment by the crown-down technique with the use of auxiliary chemical substance (2% chlorhexidine gel), foraminal patency and enlargement and filling of root canals in a single session. After persistence of sinus tract apicoectomy was indicated, which was performed under magnification and retro-filled with MTA. Apical fragment of the distal root was observed by scanning electron microscopy and excised tissue processed for microbial identification (Chapter 1). Twenty patients requiring endodontic surgery were selected. The samples were processed by microbiological techniques from microbial culture and sent for histological diagnosis (Chapter 2). Results: In chapter 1 the following species were found: Actinomyces naeslundii and Actinomyces meyeri, Propionibacterium propionicum, botullinum Clostridium, Parvimonas micra and Bacteroides ureolyticus; SEM analysis of the root end showed bacterial biofilm surrounding the apical foramen and external root surface. Gutta-percha in the apical zip caused during the first treatment was also observed. Six months follow-up showed apparent periapical repair, which was confirmed after 24 months. In chapter 2 more cysts (13/20) than granulomas (7/20) were found. Culture tests were able to identify 83 specific cultivable bacteria divided into 33 different bacterial species. The microbial characterization showed a mixed infection, composed mostly by strict anaerobes (80.4% in cysts and granulomas in 65%) and gram-positive (70.6% in cysts and granulomas in 84.4%). Although up to seven bacterial species in a single lesion (granuloma) has been isolated, in most cases, four (25%) or five (35%) species have been found. Data were statistically analyzed using Fisher's exact test and Pearson chi-square test (P<.05). Conclusions: Gram-positive bacteria and extra-radicular biofilms seem to participate in the etiology of endodontic retreatment failure. The endodontic retreatment followed by micro-periapical surgery proved to be a successful alternative in the resolution of extra-root persistent infections (Chapter 1). Although cysts were more frequent than granulomas in cases of failure of the endodontic retreatment, bacteria were isolated from both types of lesions, with a predominance of gram-positive species, suggesting that these species can survive outside the root canal and might be related with the persistence of the pathological process even after accurate endodontic retreatment (Chapter 2)
Doutorado
Endodontia
Doutora em Clínica Odontológica
Henderson, Scott Russell. "Dissecting mechanisms of granuloma formation in ANCA-associated vasculitis." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10042084/.
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Full textBooks on the topic "Granuloma"
Strukov, A. I. Granulematoznoe vospalenie i granulematoznye bolezni. Moskva: Meditsina, 1989.
Find full textLindberg, Ronny. On granulomatous enteritis and eosinophilic granulomatosis in the horse. Uppsala: Sveriges Lantbruksuniveristet, 1985.
Find full textInternational, Conference on Sarcoidosis and Other Granulomatous Disorders (10th 1984 Baltimore Md ). Tenth International Conference on Sarcoidosis and Other granulomatous disorders. New York, N.Y: New York Academy of Sciences, 1986.
Find full textNational Fish Health Research Laboratory, ed. Systemic noninfectious granulomatoses of fishes. Kearneysville, W. Va: U.S. Fish and Wildlife Service, National Fisheries Research Center-Leetown National Fish Health Research Laboratory, 1989.
Find full textHerman, Roger L. Systemic noninfectious granulomatoses of fishes. Kearneysville, W. Va: U.S. Fish and Wildlife Service, National Fisheries Research Center-Leetown National Fish Health Research Laboratory, 1989.
Find full textFriedmann, I. Granulomas and neoplasms of the larynx. Edinburgh: Churchill Livingstone, 1988.
Find full textGeraint, James D., and Zumla Alimuddin, eds. The granulomatous disorders. Cambridge, U.K: Cambridge University Press, 1999.
Find full textJaved Ali, Mohammad. The DCR Ostium Granulomas. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-33-6126-3.
Full textA, Ferlito, ed. Granulomas and neoplasms of the larynx. Edinburgh: Churchill Livingston, 1987.
Find full textMatzdorff, Axel. Erkennung aktivierter Thrombozyten mit Hilfe des [alpha]-Granula-Membran-Proteins [Alpha-Granula-Membran-Proteins] CD62p (GMP-140). [s.l.]: [s.n.], 1999.
Find full textBook chapters on the topic "Granuloma"
Jeong, Jong Yeong. "Pyogenic Granuloma: Granuloma Pyogenicum." In Dermatology Diaries, 397–401. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1578-7_97.
Full textHofman, Paul. "Granuloma." In Infectious Disease and Parasites, 132–35. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30009-2_1036.
Full textGooch, Jan W. "Granuloma." In Encyclopedic Dictionary of Polymers, 896. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13862.
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Full textDe Schepper, A. M. A., and H. R. M. Degryse. "Eosinophilic Granuloma." In Magnetic Resonance Imaging of Bone and Soft Tissue Tumors and Their Mimics, 58–59. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0997-7_11.
Full textHenderson, William R., and Emil Y. Chi. "Eosinophilic Granuloma." In Local Invasion and Spread of Cancer, 172–77. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1093-5_14.
Full textGloster, Hugh Morris, Lauren E. Gebauer, and Rachel L. Mistur. "Granuloma Annulare." In Absolute Dermatology Review, 503–5. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-03218-4_117.
Full textGloster, Hugh Morris, Lauren E. Gebauer, and Rachel L. Mistur. "Pyogenic Granuloma." In Absolute Dermatology Review, 349. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-03218-4_75.
Full textRongioletti, Franco. "Granuloma Annulare." In Encyclopedia of Pathology, 141–44. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30006-1_427.
Full textCalonje, Eduardo, and Boštjan Luzar. "Pyogenic Granuloma." In Encyclopedia of Pathology, 289–91. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30006-1_467.
Full textConference papers on the topic "Granuloma"
Schaub, R. G., and F. P. Bell. "LIPID ACCUMULATION AND METABOLISM IN CARRAGEENAN-INDUCED GRANULOMAS COMPARED TO BLOOD MONOCYTES AND THE AORTA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643410.
Full textSikka, G. "Not All Non-Caseating Granuloma Is Sarcoidosis; Reading Between the Granuloma." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3260.
Full textOliveira, Vinicius Hoffmann de, ANA MARIA RIVABEM, GABRIELA CRISTINA LEME DE CARVALHO, SABRINA PINA FINGER, and LUCIA DE FATIMA AMORIM. "REAÇÃO GRANULOMATOSA INDUZIDA PELO SCHISTOSOMA MANSONI, UMA REVISÃO INTEGRATIVA." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/5027.
Full textRibeiro de Oliveira, Marlene, Eduardo Jorge de Souza, Amujacy Tavares Vilhena, Thaís Arnoud Nascimento, Paulo Victor Ribeiro Suzuki, Lorena Américo de Freitas, Kened Gabriel Silva dos Santos, and Quênia dos Santos Oliveira Sanches. "GRANULOMA PIOGÊNICO: RELATO DE CASO." In I Simpósio de Odontologia da Região do Lago de Tucuruí - SIMPORT 2023. Tucuruí, Pará: Even3, 2023. http://dx.doi.org/10.29327/simport.702681.
Full textPengesti, Ira, Agung Dwi Wahyu Widodo, and Jusak Nugraha. "The Effect Collagen to Granuloma Structure annd Immune Response on Granuloma Tuberculosis Invitro Models." In 2nd International Conference Postgraduate School. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0007542803560360.
Full textJain, Vikas. "Massive peripheral giant cell granuloma associated with pregnancy." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685368.
Full textViswa Abhishek, N., B. G. Prabhu, and M. B. Priyadarshini. "Intubation Granuloma-Anaesthetic Management of Airway." In ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter. Indian Society of Anaesthesiologists (ISA), 2017. http://dx.doi.org/10.18311/isacon-karnataka/2017/ep106.
Full textCardoso, Bárbara Ellen, and Samir Ribeiro De Souza. "COMPLEXO GRANULOMA EOSINOFÍLICO FELINO: RELATO DE CASO." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1846.
Full textStadlhofer, R. "Giant Cell Granuloma of the temporal bone." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686511.
Full textBajwa, M., Y. Usman, H. Youness, and A. Awab. "A Rare Case of Endobronchial Pyogenic Granuloma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2326.
Full textReports on the topic "Granuloma"
Meidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, March 1995. http://dx.doi.org/10.32747/1995.7604935.bard.
Full textKamma, Dr Prudhvi Srujan, and Dr Aishwarya Badugu. AN UNUSUAL PRESENTATION OF EXTRAPULMONARY TUBERCULOSIS AS FEVER WITH PANCYTOPENIA: A CASE REPORT. World Wide Journals, February 2023. http://dx.doi.org/10.36106/ijar/5105754.
Full textWolfenson, David, William W. Thatcher, Rina Meidan, Charles R. Staples, and Israel Flamenbaum. Hormonal and Nutritional Stretegies to Optimize Reproductive Function and Improve Fertility of Dairy Cattle during Heat Stress in Summer. United States Department of Agriculture, August 1994. http://dx.doi.org/10.32747/1994.7568773.bard.
Full textNikolov, Gueorgui, Georgi N. Georgiev, Elena Marinova, Milena Mourdjeva, and Rossitza Konakchieva. Up-regulation of MT1 and MT2 Receptors by In Vitro Melatonin and Modulation of Alpha-tubulin and Aromatase P450 Expression in Human Granulosa-lutein Cells. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2020. http://dx.doi.org/10.7546/crabs.2020.03.07.
Full textWolfenson, David, William W. Thatcher, and James E. Kinder. Regulation of LH Secretion in the Periovulatory Period as a Strategy to Enhance Ovarian Function and Fertility in Dairy and Beef Cows. United States Department of Agriculture, December 2003. http://dx.doi.org/10.32747/2003.7586458.bard.
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