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Journal articles on the topic 'Grade:min:5 and up'

Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2025

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1

Von Seg Esser, L. K., M. Tönz, B. Leskosek, and M. Turina. "Evaluation of Phospholipidic Surface Coatings ex-vivo." International Journal of Artificial Organs 17, no. 5 (1994): 294–300. http://dx.doi.org/10.1177/039139889401700507.

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To evaluate the thromboresistant properties of phospholipidic surface coatings mimicking the lipid surface of blood cells, we studied four different types of phospholipids bound onto PVC tubings in comparison to uncoated as well as heparin bonded controls. The samples analyzed included diacetylenic phospholipid coated as a monomeric treatment (A), diacetylenic phospholipid polymerised prior to being coated (B), and two types of polymeric phospholipids made using methacrylate containing monomers (C and D). A bovine (bodyweight 67 ± 3 kg) left heart bypass model (pump flow 3.2 ±0.1 l/min) was se

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Rajshekhar, Vedantam, and G. Samson Sujith Kumar. "Functional Outcome after Central Corpectomy in Poor-grade Patients with Cervical Spondylotic Myelopathy or Ossified Posterior Longitudinal Ligament." Neurosurgery 56, no. 6 (2005): 1279–85. http://dx.doi.org/10.1227/01.neu.0000159713.20597.0f.

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Abstract OBJECTIVE: We studied the long-term functional outcome in poor-grade patients (Nurick Grades 4 and 5) with cervical spondylotic myelopathy (CSM) or ossified posterior longitudinal ligament after central corpectomy (CC). We sought to determine whether there were any prognostic factors that could predict functional outcome in these patients. METHODS: Functional outcome data were collected for 72 patients (68 men and 4 women; mean age, 49.7 yr; range, 30–67 yr) with CSM (60 patients) or OPLL (12 patients) of Nurick Grades 4 (55 patients) and 5 (17 patients). Uninstrumented CC was perform

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Weller, A. S., C. E. Millard, M. A. Stroud, P. L. Greenhaff, and I. A. Macdonald. "Physiological responses to cold stress during prolonged intermittent low- and high-intensity walking." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 6 (1997): R2025—R2033. http://dx.doi.org/10.1152/ajpregu.1997.272.6.r2025.

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In a previous study [Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R226-R233, 1997], the physiological responses to 240 min of intermittent low-intensity walking exercise in a cold (+5 degrees C), wet, and windy environment (Cold) may have been influenced by a 120-min preceding phase of intermittent higher-intensity exercise. Furthermore, the physiological responses observed during this latter phase may have been different if it had been more prolonged. To address these questions, active men attempted a 360-min intermittent (15 min of rest, 45 min of exercise) exercise protoc

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Chimirala, Uma Maheshwari. "Towards a convivial tool for narrative assessment: Adapting MAIN to Gondi (Dantewada, India), Halbi and Hindi for Gondi- and Halbi-Hindi speaking bilinguals." ZAS Papers in Linguistics 64 (August 31, 2020): 77–99. http://dx.doi.org/10.21248/zaspil.64.2020.561.

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   This paper presents the adaptation of MAIN to Gondi (Dantewada), Halbi and Hindi for Gondi-Hindi and Halbi-Hindi bilinguals. The Gondi and Halbi communities and the context in which Gondi-Hindi and Halbi-Hindi bilingual children are growing up are described, and the adaptation process is outlined together with its theoretical underpinnings. Finally, results from a study of 54 Halbi-Hindi bilinguals from Grade 3 (Mean age = 8.5 years), Grade 5 (Mean age = 10.9 years) and Grade 7 (Mean age = 12.9 years) are presented. The results showed that, for the macrostructure of Grade

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Shan, Bin, Wei Xiong, and Shufen Zhang. "Dyeing Method and Properties of a Novel Blue Azo-Anthraquinone Reactive Dye on Cotton." Molecules 24, no. 7 (2019): 1334. http://dx.doi.org/10.3390/molecules24071334.

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A novel blue azo-anthraquinone reactive dye was evaluated in the dyeing of cotton by using a dip–pad–steam process. Dyeing method and properties were examined in detail and the results showed that the dyeing method consisting of dye concentration of 25 g/L, sodium carbonate of 12 g/L, dipping time of 3 min and steaming time of 30 min was the most effective when a conventional “one-dip–one-nip” process was used. The fixation of the dyes on cotton could reach up to 93.4%, the wash and rub fastness both reached grade 4 above, and the light fastness reached grade 4–5 above. Such colored cotton sho

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6

Duan, C., and W. W. Winder. "Effect of endurance training on activators of glycolysis in muscle during exercise." Journal of Applied Physiology 76, no. 2 (1994): 846–52. http://dx.doi.org/10.1152/jappl.1994.76.2.846.

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Endurance training attenuates exercise-induced increases in blood lactate at the same submaximal work rate. Three intramuscular compounds that influence muscle lactate production were measured in fasted non-trained (NT) and endurance-trained (T) rats. The T rats were subjected to a progressive endurance-training program. At the end of the program (11 wk), they were running 2 h/day at 31 m/min up a 15% grade 5 days/wk. NT and T rats were fasted for 24 h and then anesthetized (pentobarbital, iv) at rest or after running for 30 min at 21 m/min (15% grade). Blood lactate levels were significantly

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Elhamaky, Tarek R. "Small incision upper blepharoplasty in the treatment of upper eyelid solitary nasal pad fat protrusion." Journal of Cutaneous and Aesthetic Surgery 16, no. 3 (2023): 210–13. http://dx.doi.org/10.4103/jcas.jcas_33_22.

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Abstract Purpose: The aim of this article is to investigate the efficacy of small incision blepharoplasty in the treatment of upper eyelid single nasal pad fat bulge. Materials and Methods: This is a prospective study of 43 eyes of 24 patients who underwent small incision upper blepharoplasty for the treatment of solitary nasal pad fat bulge. All patients underwent a comprehensive ophthalmic examination, periorbital evaluation, and patient satisfaction evaluation using Global Aesthetic Improvement Scale (GAIS) and Blepharoplasty Outcomes Evaluation (BOE) at baseline, 1 week, 3 months, and 6 mo

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Zagriadskiǐ, E. A. "Hybrid methods treatments for III and IV grade hemorrhoids." Koloproktologia 22, no. 4 (2023): 53–61. http://dx.doi.org/10.33878/2073-7556-2023-22-4-53-61.

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Aim: to evaluate hybrid techniques in patients with stage III and IV hemorrhoids.Patients and Methods: from January 2017 to December 2021, 154 patients with external and internal hemorrhoids of the 3rd and 4th stages were treated at the Moscow Medical Center “ON CLINIC”, including men — 118 (76.6%) and women — 36 (23.4%), aged of 45.8 ± 10.3 (27–72) years. The history of the disease was 8.8 ± 2.2 (5–15) years. All patients underwait transanal dearterialization with mucopexy. With its inefficiency, a hybrid operation technique was performed.Results: all patients were operated under spinal anest

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ERTAŞ, Gülçin, Muzaffer Bedri ALTUNDAĞ, Ebru ATASEVER AKKAŞ, Hayati ABANUZ, Esra KEKİLLİ, and Fatih GÖKSEL. "Local control results in extremity soft tissue sarcomas." Journal of Health Sciences and Medicine 5, no. 6 (2022): 1736–40. http://dx.doi.org/10.32322/jhsm.1175942.

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Aim: The aim of this study is to investigate local control results and effective predictive factors in local control of extremity soft tissue sarcomas, retrospectively. Material and Method: 51 patients underwent postoperative adjuvant radiotherapy (RT) in Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital between October 2008-January 2022. Patients who underwent post-operative adjuvant RT were treated with 60-68 Gy in 2 phases from 2 Gy /day using conformal radiotherapy technique. IMA chemotherapy protocol was applied to 31.4% of the patients after radiotherapy. Results:

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Winder, W. W., H. T. Yang, and J. Arogyasami. "Liver fructose 2,6-bisphosphate in rats running at different treadmill speeds." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 255, no. 1 (1988): R38—R41. http://dx.doi.org/10.1152/ajpregu.1988.255.1.r38.

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To determine the effect of work rate on liver fructose 2,6-bisphosphate (fructose 2,6-P2), rats were run for 5 min on a treadmill up a 15% grade at 16, 21, 26, 31, and 36 m/min. The liver content of fructose 2,6-P2 decreased 25, 42, 50, 62, and 71% from resting values after 5 min of running at these work rates. The time course of the decline in liver fructose 2,6-P2 was also studied in rats run at 16 m/min for times ranging from 5 to 100 min, at 23 m/min for times ranging from 5 to 60 min, and at 31 m/min for times of 5, 10, and 20 min. The hepatic content of fructose 2,6-P2 declined significa

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Khelif, David Hamid, Clement Kintzinger, Said Taha, et al. "First results of radiotherapy after hyperbaric oxygenation with temozolomide for high-grade gliomas." Journal of Clinical Oncology 30, no. 15_suppl (2012): 2048. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.2048.

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2048 Background: The outcome of patients with high-grade gliomas remains poor despite modern therapeutic arsenal. The objective of this study was to assess the feasibility and efficacy of radiotherapy (RT) given immediately after hyperbaric oxygenation (HBO) with Stupp protocol. Methods: All patients with histologically confirmed high-grade gliomas from 2008 till 2011 coveraged at GHSR hospital were enrolled. Patients underwent Stupp protocol consisting in 60 Gy RT with a daily dose of 2 Gy for 5 days per week administrated immediately after HBO. Temozolomide (TMZ) was administrated at the dai

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Kebriaei, Partow, Roland L. Basset, Celina Ledesma, et al. "Clofarabine (Clo) Plus Busulfan (Bu) Is an Effective Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients (pts) with Acute Lymphoblastic Leukemia (ALL): Long-Term Study Results." Blood 126, no. 23 (2015): 4376. http://dx.doi.org/10.1182/blood.v126.23.4376.4376.

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Abstract Allogeneic HCT improves long-term disease control in pts with ALL, but the treatment-related mortality (TRM) associated with most myeloablative transplant conditioning regimens limits the benefits of HCT. Therefore, we investigated a novel regimen consisting of Clo combined with intravenous (i.v.) Bu in adult pts with ALL undergoing allogeneic HCT. Preliminary results were encouraging1, and we now report on long-term outcomes. Methods: Clo 40 mg/m2 was infused over 60 min, each dose followed by Bu 130 mg/m2 infused over 3 hours daily for 4 days followed by hematopoietic cell infusion

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13

Sun, D., A. Huang, A. Koller, and G. Kaley. "Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats." Journal of Applied Physiology 76, no. 5 (1994): 2241–47. http://dx.doi.org/10.1152/jappl.1994.76.5.2241.

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We aimed to test the hypothesis that as a consequence of short-term daily bouts of exercise the control of arteriolar smooth muscle by endothelium is altered. Rats ran on a treadmill once a day, 5 days/wk, for 2–4 wk (with gradually increasing intensity, up to 26 min at 22 m/min at a 1% grade by the beginning of the 3rd wk and up to 38 min at 28 m/min at a 2% grade by the beginning of the 4th wk) while a control group remained sedentary (SED). Cannulated and pressurized arterioles of rat gracilis muscle developed spontaneous myogenic tone, which was slightly enhanced in exercised (EX) compared

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Fu, You, and Ryan D. Burns. "Demographic Characteristics Related to Motor Skills in Children Aged 5-7 Years Old." International Journal of Kinesiology and Sports Science 6, no. 2 (2018): 15. http://dx.doi.org/10.7575/aiac.ijkss.v.6n.2p.15.

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Background: Motor skill is important to young children’s overall well-being. However, there has been a paucity of work examining the demographic characteristics on young children’ motor skill. Objective: The purpose of this study was to examine the differences in motor skills across socio-economic status (SES) and grade levels in elementary school children. Method: Participants were 651 kindergarten to 2nd grade children (mean age = 6.2 ± 0.9 years; 305 girls, 346 boys) recruited from two low SES schools and another two high SES schools. Selected motor skill items were measured using the Test

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15

Waldecker, Ute. "Outcome of Helal osteotomy for chronic plantar foot ulcers." Foot & Ankle Orthopaedics 3, no. 3 (2018): 2473011418S0050. http://dx.doi.org/10.1177/2473011418s00506.

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Category: Diabetes Introduction/Purpose: Chronic ulceration of the forefoot is a major problem in neuropathic and diabetic feet. Foot ulceration represents a risk factor for the development of osteomyelitis and increases the risk of amputation.The purpose of this study was to evaluate the effectiveness of Helal osteotomies concerning the development of plantar foot ulcers. Methods: Eighteen patients with a mean age of 69 years (min 55 yr, max 85 yrs) suffering from chronic, refractory ulcerations of the forefoot underwent Helal osteotomies. Demographic parameters, radiologic parameters, ulcer

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Weinberg, Robert, Lawrence Bruya, Janice Longino, and Allen Jackson. "Effect of Goal Proximity and Specificity on Endurance Performance of Primary-Grade Children." Journal of Sport and Exercise Psychology 10, no. 1 (1988): 81–91. http://dx.doi.org/10.1123/jsep.10.1.81.

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The purpose of this investigation was to test the effects of goal proximity and goal specificity on endurance performance of young children. Subjects were 130 boys and 125 girls from the fourth, fifth, and sixth grades. Children were matched on baseline performance of the 2-min sit-up test and then randomly assigned to one of the following goal setting conditions: (a) short-term goal improvement of 4% each test trial, (b) long-term goal of 20% improvement over the course of the 10-week study, (c) short-term plus long-term goal, and (d) do your best. Subjects practiced sit-ups in class every da

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Marker, J. C., D. A. Arnall, R. K. Conlee, and W. W. Winder. "Effect of adrenodemedullation on metabolic responses to high-intensity exercise." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 251, no. 3 (1986): R552—R559. http://dx.doi.org/10.1152/ajpregu.1986.251.3.r552.

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To determine the role of epinephrine in glycogenolysis during high-intensity exercise, rats were adrenodemedullated (ADM) or sham operated (SHAM) and run for either 30 min at 38 m/min or for 5 min at 27, 38, or 48 m/min up a 15% grade. At the end of exercise the rats were anesthetized by intravenous injection of pentobarbital sodium. Liver, blood, and muscle samples were obtained. Plasma epinephrine values were 5.9 and 0.3 nM for SHAM and ADM animals, respectively, after 30 min of exercise. Liver glycogen decreased by 16 and 21 mg/g in the SHAM and ADM groups, respectively, and liver cAMP incr

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Hashimoto, K., T. Arai, and H. Kurosawa. "Technical Considerations and Intermediate-Term Results with Modified Devega Tricuspid Annuloplasty." Cardiovascular Surgery 1, no. 5 (1993): 573–76. http://dx.doi.org/10.1177/096721099300100521.

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Because of unsatisfactory long-term results with current DeVega tricuspid annuloplasty, 43 patients with secondary tricuspid regurgitation associated with mitral disease were treated with a modified DeVega operation. This procedure continues the suture line to the tendon of Todaro, resulting in almost circumferential traction of the tricuspid annulus. The suture is tied securely around a 29-mm or 31-mm (for women and men, respectively) ball-shaped obturator. Atrioventricular block was not observed. One patient died during the early postoperative period. During a mean(s.d.) follow-up of 5.0(2.0

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Kazi, Omair, Eric Cotter, Shane Nho, and Dominic Carreira. "FP5.3 Tönnis 1 Hips Demonstrate Significant Clinical Improvement with Low Conversion to Total Hip Arthroplasty at Mid-Term Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome: A Multicentered Propensity Matched Analysis." Journal of Hip Preservation Surgery 12, Supplement_1 (2025): i13—i14. https://doi.org/10.1093/jhps/hnaf011.041.

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Abstract Background: Mild osteoarthritis, considered as Tönnis grade 1, may be associated with inferior outcomes following hip arthroscopy (HA). Existing studies assessing the relationship between Tönnis grade and outcomes have demonstrated a wide range of clinical improvement and survivorship. Purpose: To compare mid-term functional outcomes and survivorship following HA for femoroacetabular impingement syndrome between Tönnis grade 0 and 1 hips. Methods: Within a multicenter surgical database, hips undergoing primary HA, including labral repair, femoroplasty, and capsular repair with minimum

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Cavenagh, J. D., K. Yong, J. Byrne, et al. "The Safety, Pharmacokinetics and Pharmacodynamics of KW-2478, a Novel Hsp90 Antagonist, in Patients with B-Cell Malignancies: A First-in-Man, Phase I, Multicentre, Open-Label, Dose Escalation Study." Blood 112, no. 11 (2008): 2777. http://dx.doi.org/10.1182/blood.v112.11.2777.2777.

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Abstract Treatment of cancer cells with Hsp90 inhibitors/antagonists results in cell cycle arrest, destabilisation and apoptosis. This ability of Hsp90 antagonists to modulate tumour microenvironments and initiate the selective degradation of various factors needed for cell proliferation and survival make them potential candidates for the treatment of B-cell malignancies such as multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin’s lymphoma (NHL). KW-2478 is a novel non-ansamycin, non-purine analogue antagonist for Hsp90. This study investigated KW-2478 in patients

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Vanhellemont, Anneleen, Annemarie Coolbrandt, Evi Vandeneede, et al. "Remote Patient Monitoring for Early Detection of Cytokine Release Syndrome in Myeloma Patients: A Comparative Study between Standard Care and Remote Monitoring." Blood 144, Supplement 1 (2024): 3664. https://doi.org/10.1182/blood-2024-203013.

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Introduction: Bispecific antibodies (bsAb) against BCMA, GPRC5D and FcRH5 have shown to be highly active in relapsed and refractory multiple myeloma (RRMM). Initial bsAb use can be complicated by cytokine release syndrome (CRS). Fever is a cardinal symptom of all CRS grades and step-up dosing a mitigation strategy to prevent severe CRS. Step-up dosing requires on average 7-10 days of patient monitoring, a period during which many patients are currently still hospitalized. With the advancements in wearable technology, remote patient monitoring (RPM) offers a promising approach for early CRS det

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Iravani, Masoud, Maryam Tavakoli, Ahmad Reza Shamshiri, et al. "Fludarabine and Busulfan (FluBuP Regimen) as Myeloablative Conditioning Regimen for Allogeneic PBSCT in 71 Leukemic Patients (A Unicenteric Study)." Blood 104, no. 11 (2004): 5156. http://dx.doi.org/10.1182/blood.v104.11.5156.5156.

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Abstract Following 3 other centers in USA, Canada and Germany, we are evaluating fludarabine (40 mg/m2 on days −6 to −2) and busulfan (4 mg/kg/day on days −5 to −2) as a new conditioning regimen for allogeneic peripheral blood stem cell transplantation in leukemic patients with matched related donors. Seventy one patients were enrolled, 18 with high and 53 with standard risk (18 ALL, 35 AML, 16 CML and 2 MDS; F=29 M=42). The median patient age was 23.7 years(range, 2.4– 46.7). Cyclosporine was used as a prophylactic agent for GVHD (3mg/kg IV till +4, 10 mg/kg oral from day +5). The median foll

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Acs, Miklos, Michael Gerken, Vanessa Schmitt, et al. "Role of HIPEC after Complete Cytoreductive Surgery (CRS) in Peritoneal Recurrence of Platinum-Sensitive Recurrent Ovarian Cancer (OC): The Aim for Standardization at Two Reference Centers for CRS." Cancers 15, no. 2 (2023): 405. http://dx.doi.org/10.3390/cancers15020405.

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Background: This bicentric study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for platinum-sensitive recurrent ovarian cancer patients. Methods: The data of 88 patients with the first peritoneal recurrence of platinum-sensitive epithelial ovarian cancer who underwent CRS and HIPEC from a prospective HIPEC registry were retrospectively investigated. Endpoints were feasibility, chemotherapeutic compound, time of exposure, complications, and overall survival. Results: The median follow-up was 4.7 years (95%-CI 4.6–5.5). The median age was 5

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Hanus, Francois, Nicolas Caillet, Sylvain Gaillard, and Olivier Vassart. "Strength reduction factors for S355 to S500 steel grades under steady-state and transient-state heating." Journal of Structural Fire Engineering 11, no. 2 (2019): 137–49. http://dx.doi.org/10.1108/jsfe-01-2019-0001.

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Purpose This paper aims to describe coupon tests performed at elevated temperatures on S355 to S500 steel grades and comparison of test results with previous research studies and current EN 1993-1-2 material laws. The objective is to state if these steel grades satisfy to the current material laws and if the scope of application of these laws could be extended to S500 grades. Design/methodology/approach Two experimental programmes were launched to investigate the behaviour of S460M and S500M steel grades developed for hot-rolled sections. The first research programme was focussed on a comparis

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Ayisi, Emmanuel Nyarko, and Karel Fraňa. "The Design and Test for Degradation of Energy Density of a Silica Gel-Based Energy Storage System Using Low Grade Heat for Desorption Phase." Energies 13, no. 17 (2020): 4513. http://dx.doi.org/10.3390/en13174513.

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This paper presents the design and a short cycle repeatability test of a silica gel-based thermal energy storage system using low grade heat for the desorption phase. The system was designed to test the degradation in the energy storage density of the adsorbent material for a 2 h working period in a short number of cycles (5 cycles). Low grade heat of 70 °C is used for regeneration during the desorption phase in each cycle. It was found that a reduction of 1.6 W/kg per each cycle of energy storage was observed, up to 5 cycles. The maximal heat storage density was 292 kJ/kg at the first cycle a

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Willems, M. E., J. T. Brozinick, C. E. Torgan, M. Y. Cortez, and J. L. Ivy. "Muscle glucose uptake of obese Zucker rats trained at two different intensities." Journal of Applied Physiology 70, no. 1 (1991): 36–42. http://dx.doi.org/10.1152/jappl.1991.70.1.36.

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Exercise training reduces the muscle insulin resistance of the obese Zucker rat. The purpose of the present study was to determine whether the magnitude of this training response is exercise intensity specific. Obese Zucker rats were randomly divided into sedentary (SED), low-intensity (LI), and high-intensity (HI) exercise groups. For the LI rats, exercise training consisted of running on a rodent treadmill at 18 m/min up an 8% grade for 90 min. Rats in the HI group ran at 24 m/min up an 8% grade for four 17-min bouts with 3 min between bouts. Both exercise groups performed the same amount of

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Scully, Paul R., Kush P. Patel, Thomas A. Treibel, et al. "Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation." European Heart Journal 41, no. 29 (2020): 2759–67. http://dx.doi.org/10.1093/eurheartj/ehaa170.

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Abstract Aims Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI). We hypothesized that patients with dual aortic stenosis and cardiac amyloid pathology (AS-amyloid) would have different baseline characteristics, periprocedural and mortality outcomes. Methods and results Patients aged ≥75 with severe AS referred for TAVI at two sites underwent blinded bone scintigraphy prior to intervention (Perugini Grade 0 negative, 1–3 increasingly positive). Baseline assessment included echocardiography, electrocardiogram (

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Hurst, Denise, Eric B. Taylor, Troy D. Cline, et al. "AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats." American Journal of Physiology-Endocrinology and Metabolism 289, no. 4 (2005): E710—E715. http://dx.doi.org/10.1152/ajpendo.00155.2005.

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This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) in muscles from nontrained and endurance-trained rats. Rats were trained 5 days/wk, 2 h/day for 8 wk at a final intensity of 32 m/min up a 15% grade with 30-s sprints at 53 m/min every 10 min. Gastrocnemius muscles were stimulated in situ in trained and nontrained rats for 5 min at frequencies of 0.4/s and 1/s. Gastrocnemius LKB1 protein, a putative component of the AMPKK complex (LKB1, STRAD, and MO25), increased approximately twofold in response to training. Phosphorylation of AMP-activated protein kin

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GULER, AVCI Gulhan. "Treatment Results and Dosimetric Comparison of Synchronous Bilateral Breast Cancer with Helical Tomotherapy and Volumetric-Modulated Arc Radiotherapy." Chronicles of Precision Medical Researchers 3, no. 1 (2022): 6–10. https://doi.org/10.5281/zenodo.6371495.

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<strong>Objective:</strong> The aim of this study is to present the short-term treatment results and dosimetric comparison of patients with synchronous bilateral breast cancer (SBBC) with helical tomotherapy (HT) and volumetric-modulated arc therapy (VMAT)  by actual treatment plans. <strong>Material and Methods:</strong> Twelve patients with SBBC who were diagnosed between June 2015 and June 2018, received adjuvant bilateral breast or chest wall RT were retrospectively analyzed. Seven of the patients were irradiated in helical Tomotherapy (Hi-Art ® Version 5.1.3) (HT) and the remaini

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Maleki, A., and B. Shahmoradi. "Solar degradation of Direct Blue 71 using surface modified iron doped ZnO hybrid nanomaterials." Water Science and Technology 65, no. 11 (2012): 1923–28. http://dx.doi.org/10.2166/wst.2012.091.

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This paper reports photodegradation of Direct Blue 71 under irradiation by sunlight. We synthesized Fe:ZnO nanomaterials under mild hydrothermal conditions (P = autogenous, T = 100 °C, t = 18 h). The precursors were Fe2O3 as dopant, n-butylamine as surface modifier, NaOH as mineralizer and reagent grade ZnO. The systematic experiments on the photodegradation of Direct Blue 71 were carried out by changing different effective parameters. The variables in this study were type of nanomaterials synthesized (4 types), nanomaterial dosage (0.4–1.0 g/L), contact time (30–120 min), pH (3–11), and dye c

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Maharaj, Arun, Rikeenkumar Dhaduk, Daniel A. Mulrooney, et al. "Arterial stiffness and aortic hemodynamics as predictors for new or worsening cardiovascular events in childhood cancer survivors: A report from the St. Jude lifetime cohort." Journal of Clinical Oncology 42, no. 16_suppl (2024): e24006-e24006. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e24006.

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e24006 Background: Survival following childhood cancer has improved due to advances in treatment and supportive care. However, survivors are at high risk of cardiovascular diseases (CVDs) later in life. Aortic artery stiffening, captured by measuring the speed and magnitude of forward and reflected pulse waves, is an independent predictor of CVD and mortality in the general population. Methods: We evaluated associations between vascular function and new or worsening CVDs [coronary artery disease (CAD), cardiomyopathy, and hypertension (HTN)] among a subset (n = 249) of St. Jude Lifetime Cohort

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Ceelen, Wim, Louis Sandra, Leen Van de Sande, et al. "Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases: A first in human phase I study." Journal of Clinical Oncology 39, no. 15_suppl (2021): 4065. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4065.

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4065 Background: Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) was recently introduced in the palliative treatment of peritoneal metastases (PM). Results from preclinical experiments suggest that intraperitoneal (IP) Nab-PTX may result in superior efficacy compared to solvent based paclitaxel (PTX). We performed a phase I first-in-human trial of PIPAC using Nab-PTX in patients with PM from upper gastrointestinal, breast, or ovarian cancer. Methods: Eligible patients with biopsy-proven PM underwent up to three PIPAC treatments using Nab-PTX with a four-week interval at two univer

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Anzorov, V. A., and S. V. Moryakina. "The influence of the academic performance of students on the functional state of the cardiovascular system." BIO Web of Conferences 76 (2023): 01011. http://dx.doi.org/10.1051/bioconf/20237601011.

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The article reveals the functional state of the cardiovascular system of female students with different grades in the grade book. From the evaluation of the results of our research, we can conclude that academic performance does not lead to significant changes in the indicators of the functional state of the cardiovascular system of girls. Thus, in female students with the highest academic performance, the AP value increased to 42.6 mm Hg. Art., ADsrdin up to 98.8 mm Hg. Art. and IOC up to 4.79 1/min, and in the control girls it was 40.6; 92.2 and 4.66 respectively. The level of SOC decreased

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Winder, W. W., and H. T. Yang. "Blood collection and processing for measurement of catecholamines in exercising rats." Journal of Applied Physiology 63, no. 1 (1987): 418–20. http://dx.doi.org/10.1152/jappl.1987.63.1.418.

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We have studied the time course of the decline in plasma catecholamines in the postexercise period in rats. Male Sprague-Dawley rats were run on the treadmill for 5 min at 31 m/min up a 15% grade. At the end of the exercise the rats were quickly anesthetized by intravenous injection of pentobarbital. Blood samples were collected as soon as possible (average of 43 s), at 2 and 7 min postexercise. Plasma epinephrine decreased from 0.79 +/- 0.09 ng/ml to 0.51 +/- 0.05 after 2 min and to 0.35 +/- 0.09 after 7 min. Plasma norepinephrine decreased from 0.89 +/- 0.16 ng/ml to 0.61 +/- 0.05 after 2 mi

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Bird, M. M., and A. W. Segal. "Microinjected neutrophils retain the ability to take up bacteria." Journal of Anatomy 200, no. 5 (2002): 523–34. http://dx.doi.org/10.1046/j.1469-7580.2002.00047_30.x.

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It is now possible to microinject protein to probe specific biochemical pathways and/or cell functions in small cells such as human neutrophils (Bird et al. J.Anat.198, 2001). We have shown that these cells retain their ability to modify their F‐actin cytoskeleton following the microinjection procedure. The principal task of neutrophils is to hunt and kill bacteria by responding to chemotactic gradients which cause them to extend actin rich pseudopodia in the direction of the highest concentration of these molecules. On reaching their target the neutrophils make tight contact with the bacteria

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Laughlin, M. H., R. J. Korthuis, W. L. Sexton, and R. B. Armstrong. "Regional muscle blood flow capacity and exercise hyperemia in high-intensity trained rats." Journal of Applied Physiology 64, no. 6 (1988): 2420–27. http://dx.doi.org/10.1152/jappl.1988.64.6.2420.

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The purpose of this study was to determine the effects of high-intensity treadmill exercise training on 1) the regional distribution of muscle blood flow within and among muscles in rats during high-intensity treadmill exercise (phase I) and 2) on the total and regional hindlimb skeletal muscle blood flow capacities as measured in isolated perfused rat hindquarters during maximal papaverine vasodilation (phase II). Two groups of male Sprague-Dawley rats were trained 5 days/wk for 6 wk with a program consisting of 6 bouts/day of 2.5-min runs at 60 m/min up a 15% grade with 4.5-min rest periods

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Fuchs, Charles S., Atsushi Ohtsu, Josep Tabernero, et al. "Pembrolizumab (MK-3475) plus 5-fluorouracil (5-FU) and cisplatin for first-line treatment of advanced gastric cancer: Preliminary safety data from KEYNOTE-059." Journal of Clinical Oncology 34, no. 4_suppl (2016): 161. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.161.

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161 Background: Standard first-line treatment for advanced gastric cancer includes combination chemotherapy with a platinum agent and a fluoropyrimidine. The anti–PD-1 humanized monoclonal antibody pembrolizumab (pembro) has shown promising antitumor activity as monotherapy in patients (pts) with advanced gastric cancer. We report preliminary safety data for pts with advanced gastric cancer treated with pembro + cisplatin and 5-FU in the multicohort, phase 2 KEYNOTE-059 study (NCT02335411). Methods: Eligible pts were aged ≥ 18 y and had HER2– relapsed or metastatic gastric or gastroesophageal

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Pani, Swatirupa, Nilima Dash, B. K. Mohapatra, and S. K. Singh. "Siliceous Manganese Ore from Eastern India:A Potential Resource for Ferrosilicon-Manganese Production." High Temperature Materials and Processes 38, no. 2019 (2019): 425–35. http://dx.doi.org/10.1515/htmp-2018-0081.

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AbstractSiliceous manganese ore, associated with the banded iron formation occurs in large volume in northern Odisha, India. It is a sub-grade ore containing 21% Mn, 60% SiO2 and 3% Fe, hence do not find any use and considered as waste. Such ore does not respond to any physical beneficiation techniques because of intricate microstructure and poor liberation of Mn-phase. It could only be up-graded to 32% Mn with 36% yield and 52% recovery by processing it through mineral separator followed by WHIMS. Siliceous manganese ore along with calcite and coke in appropriate ratio, when charged to a plas

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Tse, A. N., G. Raggio, M. Morse, and N. E. Kemeny. "A phase I clinical and pharmacokinetic study of escalating doses of fixed rate and escalating infusion duration of gemcitabine given via an intrahepatic pump for patients with hepatic metastases." Journal of Clinical Oncology 24, no. 18_suppl (2006): 14035. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14035.

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14035 Background: Gemcitabine (Gem) is an attractive chemotherapeutic agent for hepatic arterial infusion (HAI) because of its broad-spectrum anti-tumor activity, high systemic clearance, and possibly high hepatic extraction. Pre-clinical models indicate that cytotoxicity of gemcitabine increases with duration of drug exposure. Methods: In this phase I trial, successive cohorts of patients (Pts) with hepatic metastases of colorectal or bile duct cancer were given HAI Gem 3 out of 4 weeks. During the dose escalation phase, increasing doses of HAI Gem (800, 1000, 1200 and 1500 mg/m2) were given

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Hutber, C. Adrian, B. B. Rasmussen, and W. W. Winder. "Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise." Journal of Applied Physiology 83, no. 6 (1997): 1917–22. http://dx.doi.org/10.1152/jappl.1997.83.6.1917.

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Hutber, C. Adrian, B. B. Rasmussen, and W. W. Winder.Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise. J. Appl. Physiol. 83(6): 1917–1922, 1997.—Muscle malonyl-CoA has been postulated to regulate fatty acid metabolism by inhibiting carnitine palmitoyltransferase 1. In nontrained rats, malonyl-CoA decreases in working muscle during exercise. Endurance training is known to increase a muscle’s reliance on fatty acids as a substrate. This study was designed to investigate whether the decline in malonyl-CoA with exercise would be greater in trained than in non

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Rio, Marc M. Montifar, and Q. Velasco Cecilia. "Cloze Reading Strategy as Enrichment of Reading Comprehension Skills among Grade 5 Learners." INTERNATIONAL JOURNAL OF SOCIAL SCIENCE HUMANITY & MANAGEMENT RESEARCH 3, no. 06 (2024): 796–803. https://doi.org/10.5281/zenodo.12580386.

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The study aimed to enhance the reading comprehension skills of Grade Five pupils using Cloze Reading. The study used one group pre-test and post-test research design under pre-experimental. One section of Grade Five Pupils, composed of forty-two(42) pupils from Talisay Elementary School, contributed to the study. In gathering data, a modified pre-test and post-test by the researcher, depending on the learning needs and the desired outcome of the study, were the tools used. It comprises four variables: Sequencing of Events, Inferring, Noting Details and Identifying the Main Idea. The results of

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Finelli, Antonio, Narhari Timilshina, Maria Komisarenko та ін. "5α-reductase inhibitors and the risk of grade reclassification for men with long-term follow-up on active surveillance for prostate cancer." Journal of Clinical Oncology 34, № 2_suppl (2016): 92. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.92.

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92 Background: The role of 5α-reductase inhibitors (5-ARIs) in prostatic diseases remains controversial because of an FDA black box label. We have previously published on the impact of 5-ARIs in men managed with active surveillance (AS), demonstrating their protective effect against progression. However, the long-term safety of 5-ARIs in the setting of AS has never been described, thus we sought to assess this. Methods: This is a single-institution, prospectively maintained, retrospective cohort study comparing men taking a 5-ARI versus no 5-ARI while on AS for PCa. Pathologic progression was

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Geyer, Lisa, Konrad Brockmeier, Christine Graf, et al. "Bubble Formation in Children and Adolescents after Two Standardised Shallow Dives." International Journal of Sports Medicine 40, no. 01 (2018): 31–37. http://dx.doi.org/10.1055/a-0777-2279.

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AbstractCirculating venous bubbles after dives are associated with symptoms of decompression sickness in adults. Up to now it is not known to what extent children and adolescents are subjected to a bubble formation during their shallow dives and if there are possible indications for that. The aim of this pilot study is to investigate whether bubbles and/or symptoms occur after standardised repeated dives performed by young divers. 28 children and adolescents (13.5±1.1 years) carried out two 25 min dives to a depth of 10 m with a 90 min surface interval. Before and after, echocardiographic data

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Youssef, M., C. Ching Hui Yee, and R. Bechara. "A35 ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) OUTCOMES IN GASTROINTESTINAL SUBMUCOSAL TUMORS (SMT): A RETROSPECTIVE STUDY." Journal of the Canadian Association of Gastroenterology 8, Supplement_1 (2025): i13—i14. https://doi.org/10.1093/jcag/gwae059.035.

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Abstract Background Gastrointestinal submucosal tumors (SMTs) range from benign entities to malignant tumors that require surveillence or resection. The role of ESD in management of SMTs remains unclear. Aims We aim to evaluate the clinical and technical outcomes of ESD in the management of SMTs. Methods This study included patients with SMTs who underwent ESD at the Kingston Health Sciences Center (KHSC) between May 2017 to September 2024. Data was collected on patient demographics and tumor characteristics including size, pathology, differentiation, depth, and lymphovascular invasion (LVI).

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Nguyen Minh, Giang, and Phuong Nguyen Kim. "Measures of gender equality education for grade 1, and 2 students at primary schools in district 5, Ho Chi Minh City." Journal of Science Educational Science 67, no. 2 (2022): 145–57. http://dx.doi.org/10.18173/2354-1075.2022-0031.

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To meet the requirements of integrating gender equality education for students in grades 1 and 2 in District 5, Ho Chi Minh City according to the renovation of the 2018 educational program, the research has proposed 5 measures including 1) Setting up educational goals for gender equality when developing lesson plans with appropriate requirements; (2) Integrating the content of gender equality education into the content of teaching other subjects and educational activities; (3) Paying attention to gender equality when implementing teaching and educational methods; (4) Ensuring gender equality w

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Mazza, Daniele, Edoardo Viglietta, Leopoldo Arioli, et al. "Surgical versus conservative management of patellar re-dislocation: clinical and radiological results at a mid-term follow-up of 5 years." MOJ Orthopedics & Rheumatology 15, no. 2 (2023): 44–48. http://dx.doi.org/10.15406/mojor.2023.15.00616.

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Background: Patellar dislocation accounts for 2–3% of all knee lesions and is the second most common cause of traumatic hemarthrosis of the knee. Proper treatment is essential to minimize long term sequelae, such as recurrent dislocation, painful subluxation, and osteoarthritis. Aim: The purposes of this perspective randomized study were: 1) to evaluate the mid-term clinical and radiological results of the Elmslie–Trillat procedure for the treatment of traumatic patellar re-dislocation; and 2) to compare the results, especially radiological osteoarthritis development, with those of non-operati

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Ludwig, Heinz, Elisabeth Rauch, Thomas Kuehr, et al. "Lenalidomide and Dexamethasone for Acute Light Chain-Induced Renal Failure: Final Results of a Phase II Study." Blood 124, no. 21 (2014): 3484. http://dx.doi.org/10.1182/blood.v124.21.3484.3484.

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Abstract Background: Acute renal failure (ARF) is a frequent complication of multiple myeloma (MM) and most frequently due to clonotypic light chains (LC) causing cast nephropathy, which is associated with fast deterioration of renal function, increased risk for infections and shortened survival. Here we present the final results of a phase II study employing lenalidomide-dexamethasone as treatment for patients with acute light-chain induced ARF. Patients and methods: 35 patients with LC-induced ARF have been enrolled. Cast nephropathy was confirmed in all 15 patients who had a renal biopsy. P

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Chaskis, Elly, Martina Silvestri, Nozar Aghakhani, Fabrice Parker, and Steven Knafo. "Management and Outcome of Recurring Low-Grade Intramedullary Astrocytomas." Cancers 16, no. 13 (2024): 2417. http://dx.doi.org/10.3390/cancers16132417.

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Intramedullary astrocytomas (IMAs) are the second most frequent intramedullary tumors in adults. Low-grade IMAs (LG-IMA, WHO grade I and II) carry a better prognosis than high-grade IMAs (HG-IMAs). However, adjuvant treatment of LG-IMAs by radiotherapy (RT) and/or chemotherapy (CT) as well as treatment of tumor recurrences remains controversial. The aim of our study was to evaluate the postoperative outcome of LG-IMAs and the management of recurring tumors. We retrospectively reviewed a series of patients operated on for IMA from 1980 to 2022 in a single neurosurgical department. We retrieved

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Pepe, Pietro, Maria Tamburo, Paolo Panella, et al. "Erectile dysfunction following hydrogel injection and hypofractionated radiotherapy for prostate cancer: Our experience in 56 cases." Archivio Italiano di Urologia e Andrologia 94, no. 2 (2022): 166–68. http://dx.doi.org/10.4081/aiua.2022.2.166.

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Introduction: The incidence of erectile dysfunction (ED) in men with organ-confined prostate cancer (PCa) submitted to hypofractionated radiotherapy (HRT) has been prospectively evaluated. Materials and methods: From April 2018 to September 2020, 56 patients (median age 70 years) with cT1c PCa were treated by HRT directed to the prostate and seminal vesicle. Median PSA was 8.3 ng/ml; 20 patients (35.7%) vs. 28 (50%) vs. 8 (22.3%) had a PCa Grade Group 1 vs. 2 vs. 3, respectively. All patients underwent hydrogel injection of Space OAR and intraprostatic fiducials before HRT. The prescription do

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Shrestha, I. N., G. P. Deo, S. K. Shrestha, S. Neupane, and B. S. Regmi. "Epidural tramadol improves the quality of pain relief during labor." Journal of Chitwan Medical College 6, no. 3 (2017): 14–19. http://dx.doi.org/10.3126/jcmc.v6i3.16694.

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To study the analgesic efficacy and side effects of Tramadol for painless labor in combination with Bupivacaine. Randomized, controlled, double blind, open prospective study conducted at Department of Obstetrics and Gynaecology, Chitwan Medical College from July 1st 2015 to June 30th 2016. 100 patients of ASA Grade I and II, aged between 20-35 years willing for epidural analgesia for labor pain were included in the study. They were divided into two groups: Group A- Control group and Group B- Study group. Subjects of Group A received 10 ml of 0.25% Bupivacaine and that of Group B received 10ml

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