Journal articles on the topic 'GPCR'
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Vidad, Ashley Ryan, Stephen Macaspac, and Ho Leung Ng. "Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation." PeerJ 9 (September 24, 2021): e12219. http://dx.doi.org/10.7717/peerj.12219.
Full textGonzález-Guede, Irene, María López-Ramos, Luis Rodríguez-Rodríguez, Lydia Abasolo, Arkaitz Mucientes, and Benjamín Fernández-Gutiérrez. "Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts." Cells 13, no. 10 (May 16, 2024): 852. http://dx.doi.org/10.3390/cells13100852.
Full textTany, Ryosuke, Yuhei Goto, Yohei Kondo, and Kazuhiro Aoki. "Quantitative live-cell imaging of GPCR downstream signaling dynamics." Biochemical Journal 479, no. 8 (April 21, 2022): 883–900. http://dx.doi.org/10.1042/bcj20220021.
Full textBaidya, Mithu, Punita Kumari, Hemlata Dwivedi-Agnihotri, Shubhi Pandey, Badr Sokrat, Silvia Sposini, Madhu Chaturvedi, et al. "Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein–coupled receptors." Journal of Biological Chemistry 295, no. 30 (May 21, 2020): 10153–67. http://dx.doi.org/10.1074/jbc.ra120.013470.
Full textChattopadhyay, Amitabha. "GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets." Advances in Biology 2014 (October 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/143023.
Full textLiu, Samuel, Preston J. Anderson, Sudarshan Rajagopal, Robert J. Lefkowitz, and Howard A. Rockman. "G Protein-Coupled Receptors: A Century of Research and Discovery." Circulation Research 135, no. 1 (June 21, 2024): 174–97. http://dx.doi.org/10.1161/circresaha.124.323067.
Full textKapolka, Nicholas J., Jacob B. Rowe, Geoffrey J. Taghon, William M. Morgan, Corin R. O’Shea, and Daniel G. Isom. "Proton-gated coincidence detection is a common feature of GPCR signaling." Proceedings of the National Academy of Sciences 118, no. 28 (July 6, 2021): e2100171118. http://dx.doi.org/10.1073/pnas.2100171118.
Full textSouthern, Craig, Jennifer M. Cook, Zaynab Neetoo-Isseljee, Debra L. Taylor, Catherine A. Kettleborough, Andy Merritt, Daniel L. Bassoni, et al. "Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors." Journal of Biomolecular Screening 18, no. 5 (February 8, 2013): 599–609. http://dx.doi.org/10.1177/1087057113475480.
Full textJu, Man-Seok, and Sang Taek Jung. "Antigen Design for Successful Isolation of Highly Challenging Therapeutic Anti-GPCR Antibodies." International Journal of Molecular Sciences 21, no. 21 (November 3, 2020): 8240. http://dx.doi.org/10.3390/ijms21218240.
Full textYan, Huan, Jingling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, and Wei Kang. "An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis." Cancers 15, no. 3 (January 25, 2023): 736. http://dx.doi.org/10.3390/cancers15030736.
Full textTu, Shisheng, Rui Xu, Mengen Wang, Xi Xie, Chenchang Bao, and Dongfa Zhu. "Identification and characterization of expression profiles of neuropeptides and their GPCRs in the swimming crab, Portunus trituberculatus." PeerJ 9 (September 15, 2021): e12179. http://dx.doi.org/10.7717/peerj.12179.
Full textTakahashi, Masaki, Ryo Amano, Michiru Ozawa, Anna Martinez, Kazumasa Akita, and Yoshikazu Nakamura. "Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2." Proceedings of the National Academy of Sciences 118, no. 18 (April 28, 2021): e2019497118. http://dx.doi.org/10.1073/pnas.2019497118.
Full textLazim, Raudah, Donghyuk Suh, Jai Woo Lee, Thi Ngoc Lan Vu, Sanghee Yoon, and Sun Choi. "Structural Characterization of Receptor–Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers." International Journal of Molecular Sciences 22, no. 6 (March 22, 2021): 3241. http://dx.doi.org/10.3390/ijms22063241.
Full textRahman, Md Mominur, Md Rezaul Islam, Sadia Afsana Mim, Nasrin Sultana, Dinesh Kumar Chellappan, Kamal Dua, Mohammad Amjad Kamal, Rohit Sharma, and Talha Bin Emran. "Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation." Oxidative Medicine and Cellular Longevity 2022 (September 21, 2022): 1–22. http://dx.doi.org/10.1155/2022/8425640.
Full textLuttrell, Louis M., and Robert J. Lefkowitz. "The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals." Journal of Cell Science 115, no. 3 (February 1, 2002): 455–65. http://dx.doi.org/10.1242/jcs.115.3.455.
Full textBerger, Miles, David W. Scheel, Hector Macias, Takeshi Miyatsuka, Hail Kim, Phuong Hoang, Greg M. Ku, et al. "Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion." Proceedings of the National Academy of Sciences 112, no. 9 (February 18, 2015): 2888–93. http://dx.doi.org/10.1073/pnas.1319378112.
Full textWang, Xiaoyan, Ning Sui, Dandan Hu, Ziwei Zhang, and Tiejun Bing. "Abstract 4712: GPCR panel establishment and application in drug discovery." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4712. http://dx.doi.org/10.1158/1538-7445.am2024-4712.
Full textKapolka, N. J., G. J. Taghon, J. B. Rowe, W. M. Morgan, J. F. Enten, N. A. Lambert, and D. G. Isom. "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery." Proceedings of the National Academy of Sciences 117, no. 23 (May 20, 2020): 13117–26. http://dx.doi.org/10.1073/pnas.2000430117.
Full textPFLEGER, Kevin D. G., and Karin A. EIDNE. "Monitoring the formation of dynamic G-protein-coupled receptor–protein complexes in living cells." Biochemical Journal 385, no. 3 (January 24, 2005): 625–37. http://dx.doi.org/10.1042/bj20041361.
Full textWakeling, Madeleine N., Douglas J. Roy, Anthony A. Nash, and James P. Stewart. "Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor." Journal of General Virology 82, no. 5 (May 1, 2001): 1187–97. http://dx.doi.org/10.1099/0022-1317-82-5-1187.
Full textParadis, Justine S., Stevenson Ly, Élodie Blondel-Tepaz, Jacob A. Galan, Alexandre Beautrait, Mark G. H. Scott, Hervé Enslen, Stefano Marullo, Philippe P. Roux, and Michel Bouvier. "Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression." Proceedings of the National Academy of Sciences 112, no. 37 (August 31, 2015): E5160—E5168. http://dx.doi.org/10.1073/pnas.1508836112.
Full textBarwell, James, Mark Wheatley, Alex C. Conner, Bruck Taddese, Shabana Vohra, Christopher A. Reynolds, and David R. Poyner. "The activation of the CGRP receptor." Biochemical Society Transactions 41, no. 1 (January 29, 2013): 180–84. http://dx.doi.org/10.1042/bst20120251.
Full textZheng, Chen, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, and Vsevolod V. Gurevich. "GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements." Cells 12, no. 12 (June 6, 2023): 1563. http://dx.doi.org/10.3390/cells12121563.
Full textEllisdon, Andrew M., and Michelle L. Halls. "Compartmentalization of GPCR signalling controls unique cellular responses." Biochemical Society Transactions 44, no. 2 (April 11, 2016): 562–67. http://dx.doi.org/10.1042/bst20150236.
Full textLorenzen, Emily, Tea Dodig-Crnković, Ilana B. Kotliar, Elisa Pin, Emilie Ceraudo, Roger D. Vaughan, Mathias Uhlèn, Thomas Huber, Jochen M. Schwenk, and Thomas P. Sakmar. "Multiplexed analysis of the secretin-like GPCR-RAMP interactome." Science Advances 5, no. 9 (September 2019): eaaw2778. http://dx.doi.org/10.1126/sciadv.aaw2778.
Full textZhao, Xiaoning, Adrie Jones, Keith R. Olson, Kun Peng, Tom Wehrman, Adam Park, Rommel Mallari, Danilo Nebalasca, Stephen W. Young, and Shou-Hua Xiao. "A Homogeneous Enzyme Fragment Complementation-Based β-Arrestin Translocation Assay for High-Throughput Screening of G-Protein-Coupled Receptors." Journal of Biomolecular Screening 13, no. 8 (July 25, 2008): 737–47. http://dx.doi.org/10.1177/1087057108321531.
Full textSutkeviciute, Ieva, and Jean-Pierre Vilardaga. "Structural insights into emergent signaling modes of G protein–coupled receptors." Journal of Biological Chemistry 295, no. 33 (June 22, 2020): 11626–42. http://dx.doi.org/10.1074/jbc.rev120.009348.
Full textSato. "Conserved 2nd Residue of Helix 8 of GPCR May Confer the Subclass-Characteristic and Distinct Roles through a Rapid Initial Interaction with Specific G Proteins." International Journal of Molecular Sciences 20, no. 7 (April 9, 2019): 1752. http://dx.doi.org/10.3390/ijms20071752.
Full textRivero-Müller, Adolfo, Yen-Yin Chou, Inhae Ji, Svetlana Lajic, Aylin C. Hanyaloglu, Kim Jonas, Nafis Rahman, Tae H. Ji, and Ilpo Huhtaniemi. "Rescue of defective G protein–coupled receptor function in vivo by intermolecular cooperation." Proceedings of the National Academy of Sciences 107, no. 5 (January 11, 2010): 2319–24. http://dx.doi.org/10.1073/pnas.0906695106.
Full textChini, Bice, and Marco Parenti. "G-protein-coupled receptors, cholesterol and palmitoylation: facts about fats." Journal of Molecular Endocrinology 42, no. 5 (January 8, 2009): 371–79. http://dx.doi.org/10.1677/jme-08-0114.
Full textZhu, Siyu, Meixian Wu, Ziwei Huang, and Jing An. "Trends in application of advancing computational approaches in GPCR ligand discovery." Experimental Biology and Medicine 246, no. 9 (February 27, 2021): 1011–24. http://dx.doi.org/10.1177/1535370221993422.
Full textCroft, Wayne, Claire Hill, Eilish McCann, Michael Bond, Manuel Esparza-Franco, Jeannette Bennett, David Rand, John Davey, and Graham Ladds. "A Physiologically Required G Protein-coupled Receptor (GPCR)-Regulator of G Protein Signaling (RGS) Interaction That Compartmentalizes RGS Activity." Journal of Biological Chemistry 288, no. 38 (July 30, 2013): 27327–42. http://dx.doi.org/10.1074/jbc.m113.497826.
Full textAgbedanu, P., No author No author, M. Brewer, No author No author, T. Day, M. Kimber, K. Anderson, S. Rasmussen, and M. Carlson. "Involvement of a putative intercellular signal-recognizing G protein-coupled receptor in the engulfment of Salmonella by the protozoan Tetrahymena." Open Veterinary Journal 5, no. 2 (2013): 69. http://dx.doi.org/10.5455/ovj.2013.v3.i2.p69.
Full textGupte, Tejas M., Rabia U. Malik, Ruth F. Sommese, Michael Ritt, and Sivaraj Sivaramakrishnan. "Priming GPCR signaling through the synergistic effect of two G proteins." Proceedings of the National Academy of Sciences 114, no. 14 (March 21, 2017): 3756–61. http://dx.doi.org/10.1073/pnas.1617232114.
Full textJiang, Yuhong, Xin Zhuo, and Canquan Mao. "G Protein-coupled Receptors in Cancer Stem Cells." Current Pharmaceutical Design 26, no. 17 (June 7, 2020): 1952–63. http://dx.doi.org/10.2174/1381612826666200305130009.
Full textVenkatakrishnan, A. J., Anthony K. Ma, Rasmus Fonseca, Naomi R. Latorraca, Brendan Kelly, Robin M. Betz, Chaitanya Asawa, Brian K. Kobilka, and Ron O. Dror. "Diverse GPCRs exhibit conserved water networks for stabilization and activation." Proceedings of the National Academy of Sciences 116, no. 8 (February 6, 2019): 3288–93. http://dx.doi.org/10.1073/pnas.1809251116.
Full textZheng, Liang-Hong, Chang-He Wang, Shu-Jiang Shang, Xiao-Yu Zhang, Ye-Shi Wang, Qi-Hui Wu, Mei-Qin Hu, et al. "Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells." American Journal of Physiology-Cell Physiology 305, no. 7 (October 1, 2013): C751—C760. http://dx.doi.org/10.1152/ajpcell.00335.2012.
Full textCheng, Han, Calli M. Lear-Rooney, Lisa Johansen, Elizabeth Varhegyi, Zheng W. Chen, Gene G. Olinger, and Lijun Rong. "Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists." Journal of Virology 89, no. 19 (July 22, 2015): 9932–38. http://dx.doi.org/10.1128/jvi.01337-15.
Full textWang, Lei, Lu Zhu, Jaroslawna Meister, Derek B. J. Bone, Sai P. Pydi, Mario Rossi, and Jürgen Wess. "Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs." Annual Review of Pharmacology and Toxicology 61, no. 1 (January 6, 2021): 421–40. http://dx.doi.org/10.1146/annurev-pharmtox-030220-121042.
Full textHou, Tianling, Yuemin Bian, Terence McGuire, and Xiang-Qun Xie. "Integrated Multi-Class Classification and Prediction of GPCR Allosteric Modulators by Machine Learning Intelligence." Biomolecules 11, no. 6 (June 11, 2021): 870. http://dx.doi.org/10.3390/biom11060870.
Full textWouters, Vasudevan, Crans, Saini, and Stove. "Luminescence- and Fluorescence-Based Complementation Assays to Screen for GPCR Oligomerization: Current State of the Art." International Journal of Molecular Sciences 20, no. 12 (June 17, 2019): 2958. http://dx.doi.org/10.3390/ijms20122958.
Full textSuteau, Valentine, Mathilde Munier, Rym Ben Boubaker, Méline Wery, Daniel Henrion, Patrice Rodien, and Claire Briet. "Identification of Dysregulated Expression of G Protein Coupled Receptors in Endocrine Tumors by Bioinformatics Analysis: Potential Drug Targets?" Cells 11, no. 4 (February 17, 2022): 703. http://dx.doi.org/10.3390/cells11040703.
Full textRozenfeld, Raphael, and Lakshmi A. Devi. "Exploring a role for heteromerization in GPCR signalling specificity." Biochemical Journal 433, no. 1 (December 15, 2010): 11–18. http://dx.doi.org/10.1042/bj20100458.
Full textWu, Na, Agnieszka M. Olechwier, Cyrill Brunner, Patricia C. Edwards, Ching-Ju Tsai, Christopher G. Tate, Gebhard F. X. Schertler, et al. "High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs." Proceedings of the National Academy of Sciences 118, no. 31 (July 29, 2021): e2024146118. http://dx.doi.org/10.1073/pnas.2024146118.
Full textZhang, Yinjie, Boyang Jason Wu, Xiaolan Yu, Ping Luo, Hao Ye, Yan Yu, Wei Han, and Jingjing Li. "Development of an Antigen-Antibody Co-Display System for Detecting Interaction of G-Protein-Coupled Receptors and Single-Chain Variable Fragments." International Journal of Molecular Sciences 22, no. 9 (April 29, 2021): 4711. http://dx.doi.org/10.3390/ijms22094711.
Full textKwon, Yong-Jun, Weontae Lee, Auguste Genovesio, and Neil Emans. "A High-Content Subtractive Screen for Selecting Small Molecules Affecting Internalization of GPCRs." Journal of Biomolecular Screening 17, no. 3 (November 15, 2011): 379–85. http://dx.doi.org/10.1177/1087057111427347.
Full textOsmond, Ronald I. W., Antony Sheehan, Romana Borowicz, Emma Barnett, Georgina Harvey, Cheryl Turner, Andrea Brown, Michael F. Crouch, and Anthony R. Dyer. "GPCR Screening via ERK 1/2: A Novel Platform for Screening G Protein–Coupled Receptors." Journal of Biomolecular Screening 10, no. 7 (September 16, 2005): 730–37. http://dx.doi.org/10.1177/1087057105277968.
Full textJastrzebska, Beata, Yaroslav Tsybovsky, and Krzysztof Palczewski. "Complexes between photoactivated rhodopsin and transducin: progress and questions." Biochemical Journal 428, no. 1 (April 28, 2010): 1–10. http://dx.doi.org/10.1042/bj20100270.
Full textNoonan, Theresa, Katrin Denzinger, Valerij Talagayev, Yu Chen, Kristina Puls, Clemens Alexander Wolf, Sijie Liu, Trung Ngoc Nguyen, and Gerhard Wolber. "Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence." Pharmaceuticals 15, no. 11 (October 22, 2022): 1304. http://dx.doi.org/10.3390/ph15111304.
Full textKotliar, Ilana B., Annika Bendes, Leo Dahl, Yuanhuang Chen, Marcus Saarinen, Emilie Ceraudo, Tea Dodig-Crnković, et al. "Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins." Science Advances 10, no. 31 (August 2, 2024). http://dx.doi.org/10.1126/sciadv.ado9959.
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