Academic literature on the topic 'GPCR'
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Journal articles on the topic "GPCR"
Vidad, Ashley Ryan, Stephen Macaspac, and Ho Leung Ng. "Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation." PeerJ 9 (September 24, 2021): e12219. http://dx.doi.org/10.7717/peerj.12219.
Full textGonzález-Guede, Irene, María López-Ramos, Luis Rodríguez-Rodríguez, Lydia Abasolo, Arkaitz Mucientes, and Benjamín Fernández-Gutiérrez. "Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts." Cells 13, no. 10 (May 16, 2024): 852. http://dx.doi.org/10.3390/cells13100852.
Full textTany, Ryosuke, Yuhei Goto, Yohei Kondo, and Kazuhiro Aoki. "Quantitative live-cell imaging of GPCR downstream signaling dynamics." Biochemical Journal 479, no. 8 (April 21, 2022): 883–900. http://dx.doi.org/10.1042/bcj20220021.
Full textBaidya, Mithu, Punita Kumari, Hemlata Dwivedi-Agnihotri, Shubhi Pandey, Badr Sokrat, Silvia Sposini, Madhu Chaturvedi, et al. "Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein–coupled receptors." Journal of Biological Chemistry 295, no. 30 (May 21, 2020): 10153–67. http://dx.doi.org/10.1074/jbc.ra120.013470.
Full textChattopadhyay, Amitabha. "GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets." Advances in Biology 2014 (October 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/143023.
Full textLiu, Samuel, Preston J. Anderson, Sudarshan Rajagopal, Robert J. Lefkowitz, and Howard A. Rockman. "G Protein-Coupled Receptors: A Century of Research and Discovery." Circulation Research 135, no. 1 (June 21, 2024): 174–97. http://dx.doi.org/10.1161/circresaha.124.323067.
Full textKapolka, Nicholas J., Jacob B. Rowe, Geoffrey J. Taghon, William M. Morgan, Corin R. O’Shea, and Daniel G. Isom. "Proton-gated coincidence detection is a common feature of GPCR signaling." Proceedings of the National Academy of Sciences 118, no. 28 (July 6, 2021): e2100171118. http://dx.doi.org/10.1073/pnas.2100171118.
Full textSouthern, Craig, Jennifer M. Cook, Zaynab Neetoo-Isseljee, Debra L. Taylor, Catherine A. Kettleborough, Andy Merritt, Daniel L. Bassoni, et al. "Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors." Journal of Biomolecular Screening 18, no. 5 (February 8, 2013): 599–609. http://dx.doi.org/10.1177/1087057113475480.
Full textJu, Man-Seok, and Sang Taek Jung. "Antigen Design for Successful Isolation of Highly Challenging Therapeutic Anti-GPCR Antibodies." International Journal of Molecular Sciences 21, no. 21 (November 3, 2020): 8240. http://dx.doi.org/10.3390/ijms21218240.
Full textYan, Huan, Jingling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, and Wei Kang. "An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis." Cancers 15, no. 3 (January 25, 2023): 736. http://dx.doi.org/10.3390/cancers15030736.
Full textDissertations / Theses on the topic "GPCR"
Blankenship, Elise. "Conserved solvent networks in GPCR activation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1458221506.
Full textPoudel, Sagar. "GPCR-Directed Libraries for High Throughput Screening." Thesis, University of Skövde, School of Humanities and Informatics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-29.
Full textGuanine nucleotide binding protein (G-protein) coupled receptors (GPCRs), the largest receptor family, is enormously important for the pharmaceutical industry as they are the target of 50-60% of all existing medicines. Discovery of many new GPCR receptors by the “human genome project”, open up new opportunities for developing novel therapeutics. High throughput screening (HTS) of chemical libraries is a well established method for finding new lead compounds in drug discovery. Despite some success this approach has suffered from the near absence of more focused and specific targeted libraries. To improve the hit rates and to maximally exploit the full potential of current corporate screening collections, in this thesis work, identification and analysis of the critical drug-binding positions within the GPCRs were done, based on their overall sequence, their transmembrane regions and their drug binding fingerprints. A proper classification based on drug binding fingerprints on the basis for a successful pharmacophore modelling and virtual screening were done, which facilities in the development of more specific and focused targeted libraries for HTS.
Majin, Wodu. "Mathematical modelling of GPCR-mediated calcium signalling." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12451/.
Full textTang, Lisa Sarah. "GPCR expressions in Saccharomyces cerevisiae : engineering transductions." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423190.
Full textMishra, Satyakam. "Frequent Subgraph Mining Analysis of GPCR Activation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1613575702373053.
Full textKiess, Alexandra. "Funktionelle Relevanz intrazellulärer Splicevarianten des Brain-specific Angiogenesis Inhibitor 2 (BAI2)." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-156171.
Full textSladek, Barbara. "Structural studies of integral membrane GPCR accessory proteins." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:09bf7ada-8e58-49f4-a979-bcd0cec95e8b.
Full textRichardson, Kathryn. "Mechanisms of GPCR signal regulation in fission yeast." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/63554/.
Full textGoddard, Alan David. "Functional analysis of GPCR signalling cascades in Schizosaccharomyces pombe." Thesis, University of Warwick, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437696.
Full textKoyama, Hiroyuki. "Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells." Kyoto University, 2016. http://hdl.handle.net/2433/215953.
Full textBooks on the topic "GPCR"
Gilchrist, Annette, ed. GPCR Molecular Pharmacology and Drug Targeting. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470627327.
Full textHeifetz, Alexander, ed. Computational Methods for GPCR Drug Discovery. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7465-8.
Full textDupré, Denis J., Terence E. Hébert, and Ralf Jockers, eds. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4765-4.
Full textAnnette, Gilchrist, ed. GPCR molecular pharmacology and drug targeting: Shifting paradigms and new directions. Hoboken, N.J: Wiley, 2010.
Find full textYona, Simon, and Martin Stacey, eds. Adhesion-GPCRs. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7913-1.
Full textStrasser, Andrea, and Hans-Joachim Wittmann. Modelling of GPCRs. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-4596-4.
Full textLebon, Guillaume, ed. Structure and Function of GPCRs. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24591-7.
Full textStrasser, Andrea. Modelling of GPCRs: A Practical Handbook. Dordrecht: Springer Netherlands, 2013.
Find full textS, Baker Gregory, and Jol H. M, eds. Stratigraphic analyses using GPR. Boulder, Colo: Geological Society of America, 2007.
Find full textBourne, H., R. Horuk, J. Kuhnke, and H. Michel, eds. GPCRs: From Deorphanization to Lead Structure Identification. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-48982-5.
Full textBook chapters on the topic "GPCR"
Manji, Husseini K., Jorge Quiroz, R. Andrew Chambers, Anthony Absalom, David Menon, Patrizia Porcu, A. Leslie Morrow, et al. "GPCR." In Encyclopedia of Psychopharmacology, 561. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1464.
Full textJones, Roger D., and Alan M. Jones. "A Proposed Mechanism for in vivo Programming Transmembrane Receptors." In Communications in Computer and Information Science, 123–37. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-57430-6_11.
Full textWu, Yiran, Jiahui Tong, Kang Ding, Qingtong Zhou, and Suwen Zhao. "GPCR Allosteric Modulator Discovery." In Advances in Experimental Medicine and Biology, 225–51. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8719-7_10.
Full textKnapp, Barbara, and Uwe Wolfrum. "Adhesion GPCR-Related Protein Networks." In Adhesion G Protein-coupled Receptors, 147–78. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41523-9_8.
Full textButcher, Adrian J., Andrew B. Tobin, and Kok Choi Kong. "Examining Site-Specific GPCR Phosphorylation." In Methods in Molecular Biology, 237–49. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-126-0_12.
Full textGilchrist, Annette, and Maria R. Mazzoni. "Traditional GPCR Pharmacology and Beyond." In Signal Transduction: Pathways, Mechanisms and Diseases, 3–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02112-1_1.
Full textStrasser, Andrea, and Hans-Joachim Wittmann. "Special Topics in GPCR Research." In Modelling of GPCRs, 105–20. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4596-4_8.
Full textMiljus, Tamara, David A. Sykes, Clare R. Harwood, Ziva Vuckovic, and Dmitry B. Veprintsev. "GPCR Solubilization and Quality Control." In Methods in Molecular Biology, 105–27. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0373-4_8.
Full textZhao, Qi, Amanda Chapman, Yan Huang, Mary Ferguson, Shannon McBride, Meghan Kelly, Michael Weiner, and Xiaofeng Li. "Ligand-Directed GPCR Antibody Discovery." In Methods in Molecular Biology, 319–42. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1811-0_19.
Full textGrinde, Ellinor, and Katharine Herrick-Davis. "Class A GPCR: Serotonin Receptors." In G-Protein-Coupled Receptor Dimers, 129–72. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_6.
Full textConference papers on the topic "GPCR"
Xie, X. "GPCR-targeted drug discovery." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399677.
Full textSadova, A. A., D. A. Dmitrieva, N. A. Safronova, M. B. Shevtsov, T. S. Kurkin, V. I. Borshevskiy, and A. V. Mishin. "PREPARATION OF GPCR ANTIBODY COMPLEX SAMPLES FOR CRYO-ELECTRON MICROSCOPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-211.
Full textBekhouche, Safia, and Yamina Mohamed Ben Ali. "Optimizing the identification of GPCR function." In SMC '19: The Second Conference of the Moroccan Classification Society. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3314074.3314082.
Full textFang, Ye, Anthony G. Frutos, and Joydeep Lahiri. "G protein-coupled receptor (GPCR) microarrays." In International Symposium on Biomedical Optics, edited by Darryl J. Bornhop, David A. Dunn, Raymond P. Mariella, Jr., Catherine J. Murphy, Dan V. Nicolau, Shuming Nie, Michelle Palmer, and Ramesh Raghavachari. SPIE, 2002. http://dx.doi.org/10.1117/12.472073.
Full textRobleto, Valeria, Ya Zhuo, Joseph Crecelius, and Adriano Marchese. "Regulation of GPCR Signaling by Sorting Nexins." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.276700.
Full textFranchini, Luca, Lindsay R. Watkins, and Cesare Orlandi. "Enhanced cAMP-based assay for GPCR deorphanization." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.148500.
Full textQiu, Wang-Ren, Xuan Xiao, and Zhen-Yu Zhang. "Using AdaboostSVM to Predict the GPCR Functional Classes." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515639.
Full textWÜTHRICH, KURT. "STUDIES OF GPCR CONFORMATIONS IN NON-CRYSTALLINE MILIEUS." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0026.
Full textROTH, BRYAN L. "THE HIDDEN PHARMACOLOGY OF THE HUMAN GPCR-OME." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0029.
Full textBrooks, Charles L. "De novo modeling of GPCR class A structures." In Distributed Processing (IPDPS). IEEE, 2009. http://dx.doi.org/10.1109/ipdps.2009.5160868.
Full textReports on the topic "GPCR"
Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, July 2003. http://dx.doi.org/10.32747/2003.7695850.bard.
Full textCampos, D. Ground penetrating radar (GPR) methods. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2012. http://dx.doi.org/10.4095/291772.
Full textKarp, Brad, and H. T. Kung. GPSR: Greedy Perimeter Stateless Routing for Wireless Networks. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada440078.
Full textNelson, S. D. EM modeling for GPIR using 3D FDTD modeling codes. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/93462.
Full textDubcovsky, Jorge, Tzion Fahima, and Ann Blechl. Positional cloning of a gene responsible for high grain protein content in tetraploid wheat. United States Department of Agriculture, September 2003. http://dx.doi.org/10.32747/2003.7695875.bard.
Full textCook, Samantha, Marissa Torres, Nathan Lamie, Lee Perren, Scott Slone, and Bonnie Jones. Automated ground-penetrating-radar post-processing software in R programming. Engineer Research and Development Center (U.S.), September 2022. http://dx.doi.org/10.21079/11681/45621.
Full textKositsky, Joel, and Peyman Milanfar. A Forward-Looking High-Resolution GPR System. Fort Belvoir, VA: Defense Technical Information Center, April 1999. http://dx.doi.org/10.21236/ada461034.
Full textReynolds, R. Michael, and Ernie Lewis. Marine ARM GPCI Investigation of Clouds Psychrometer Field Campaign Report. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1324981.
Full textLewis, Ernie R. Marine ARM GPCI Investigation of Clouds (MAGIC) Field Campaign Report. Office of Scientific and Technical Information (OSTI), December 2016. http://dx.doi.org/10.2172/1343577.
Full textDubcovsky, Jorge, Tzion Fahima, Ann Blechl, and Phillip San Miguel. Validation of a candidate gene for increased grain protein content in wheat. United States Department of Agriculture, January 2007. http://dx.doi.org/10.32747/2007.7695857.bard.
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