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1
Bognar, Katalin. "Modélisation du gout." Chambéry, 1997. http://www.theses.fr/1997CHAMS009.
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L’objectif de ce travail est la modélisation du gout ; plus précisément un des buts est la prédiction du profil sensoriel donne par un individu goutant un plat ; l'individu étant déjà connu par les résultats d'une série de dégustations exécutées auparavant. Mesurer le gout d'un plat est une activité combinée qui consiste d'une part à gouter le plat préparé et d'autre part à exprimer les perceptions éveillées. Le modèle d'un plat est lié à la recette à partir de laquelle il a été préparé. Ici ; les recettes sont exprimées dans un langage, cordon bleu, que nous avons développé, qui ressemble à un langage de programmation. Ainsi, les recettes sont représentées de façon manipulable et compréhensible. Pour mettre au point le modèle de gouteur nous avons utilisé la pratique de l'analyse sensorielle et nous utilise un certain nombre d'expériences dans le domaine des profils sensoriels. Les recettes, en cordon bleu, nous permettent de calculer ce que nous appelons le profil sensoriel de l'ordinateur. Le profil sensoriel (pour un plat) d'un gouteur est calculé à partir du profil sensoriel de l'ordinateur qui est perturbé en utilisant des connaissances préalables sur le gouteur. La comparaison des profils sensoriels estimés aux résultats expérimentaux (limites à 5 recettes et 11 assesseurs) indique qu'on peut les prédire avec une bonne précision, meilleure qu'une moyenne. De plus, l'analyse des résultats indique les profils sensoriels calculés par ordinateur sont de meilleurs prédicteurs que les individus eux-mêmes, dont les réponses changent avec le temps.
2
Glubochenko, O. V. "Spinal gout: clinical aspects." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19563.
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Piredda, Valfrido-Roland. "La protection des oeuvres gastronomiques, en droit d'auteur français." Paris 11, 2000. http://www.theses.fr/2000PA111013.
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Doit-on reconnaitre a l'oeuvre gastronomique un statut juridique autre que celui d'une simple marchandise ? on peut croire que << les oeuvres gastronomiques sont le fruit de cette faculte qu'a l'homme de forger et de saisir des concepts alimentaires originaux et de les traduire dans des mets, en vertu de son entendement mais aussi de son esprit >>. Cette position constitue le sujet d'un vaste debat: rien n'a encore ete tranche dans le domaine alimentaire et gastronomique, alors que le public se mefie des mefaits d'une industrialisation pas toujours bien maitrisee. La presente etude - en 2 parties - developpe la these qu'une protection des oeuvres gastronomiques en droit d'auteur est possible, sous certaines conditions, conceptuelles et legales. Dans une premiere partie, on rappelle que lesoeuvres gastronomiques font l'objet d'un developpement litteraire considerable puisque les sensations gustatives peuvent etre aussi exprimees par des mots. Par ailleurs, la reproduction d'images d'oeuvres a caractere gastronomique font aussi l'objet d'une protection en droit d'auteur a condition que leurs formes apparentes soient originales. Dans une deuxieme partie, on traite de cette creativitegastronomique qu'il faut valoriser mais qui possede la particularite de s'adresser au sens du gout : on tente de comprendre pourquoi le droit d'auteur a delaisse, des ses origines, certaines oeuvres dont celles de l'art gastronomique. Ensuite, il s'agit d'argumenter sur la maniere de proteger, en droit d'auteur, une creativite que de nouvelles formes de production et de commercialisation, en matiere alimentaire, exposent a un vrai pillage. Or, quand ce droit ne peut pas offrir sa protection, il devient indispensable de rechercher d'autres substituts a ce droit et de les mettre opportunement en pratique : pour cette raison, il fallait terminer cette these par un examen concis des techniques juridiques qui constituent en quelque sorte des palliatifs au droit d'auteur.
4
Андруша, Аліна Борисівна, and Alina Andrusha. "Peculiarities of gouty arthritis in smokers." Thesis, ХНМУ, 2017. http://repo.knmu.edu.ua/handle/123456789/15811.
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Course of gouty arthritis has clinical and laboratory features,
depending on the patient's smoking status. It can be assumed that smoking can
reduce the frequency of attacks of gouty arthritis and reduce the concentration of
uric acid in the blood, without affecting the urinary excretion of uric acid.
Additional research is needed to understandand and to explaine mechanisms of this
finding.
5
Howren, Alyssa. "Management of gout from the patient perspective." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62662.
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Thanassoulis, George. "Gout and allopurinol use in heart failure." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103495.
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Heart failure (HF) and gout are common medical conditions that lead to significant morbidity and mortality in Canada and the US. We conducted a population-based nested case-control study to investigate the associations between gout, allopurinol use and HF outcomes using administrative data from the province of Quebec. Our analysis demonstrates that a history of gout is associated with increased HF readmission and death in HF patients (adjusted RR 1.63; 95% confidence interval (CI) 1.48-1.80). We also show that chronic allopurinol use, a common medication for gout, is associated with reductions in adverse outcomes in HF patients with a history of gout (adjusted RR 0.69, 95% CI 0.60-0.79). Due to the observational nature of our study, residual confounding due to unknown or unmeasured confounding could still bias our findings. Herein, we present a novel method to estimate and control for such confounding by estimating the confounding risk ratio during the null induction time. Use of this method is illustrated using an example from the literature and we discuss the assumptions, limitations and statistical considerations of our method.L'insuffisance cardiaque (IC) et la goutte sont des conditions médicales fréquentes qui sont des causes importantes de morbidité et de mortalité au Canada et aux États-Unis. Nous avons entrepris une étude populationelle « case-control » avec des données administratives de la province du Québec pour investiguer l'association entre la goutte ou l'allopurinol avec le prognostic de l'IC. Notre analyse démontre qu'un antécedent de goutte est associé à une hausse du taux de réadmissions à l'hôpital pour l'IC et une augmentation de la mortalité parmi les patients avec IC (RR ajusté 1.63; 95% CI 1.48-1.80). Cependant, nous demontrons que la prise d'allopurinol est associée à une réduction de la réadmission à l'hôpital pour IC et une diminution de la mortalité (RR ajusté 0.69, 95% CI 0.60-0.79). Comme notre étude est observationelle, les facteurs confondants qui ne sont pas disponibles ou qui sont inconnus peuvent biaiser nos résultats. Nous présentons une nouvelle méthode qui permet l'estimation et le contrôle de ces facteurs confondants basée sur l'estimation du « confounding rate ratio ». Nous présentons un example utilisant cette nouvelle méthode, et nous discutons les suppositions, les limitations et les considérations statistiques de cette méthode.
7
Froloff, Nicolas. "Modélisation moléculaire des sites récepteurs du gout." Palaiseau, Ecole polytechnique, 1994. http://www.theses.fr/1994EPXX0009.
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Un grand nombre de données expérimentales sur le système gustatif périphérique suggèrent l'existence de sites récepteurs multiples, de faible affinité et de faible spécificité, responsables de la détection et de la discrimination parfaite d'un nombre illimité de molécules organiques. Selon cette hypothèse, un site récepteur gustatif peut lier de nombreuses molécules, de même qu'une molécule peut interagir avec plusieurs types de sites récepteurs. L'analyse statistique des estimations d'intensité, réalisées par plusieurs dizaines de sujets humains pour diverses molécules, permet de calculer des distances intermoléculaires biologiques, deux molécules «étant d'autant plus proches qu'elles interagissent avec des sites récepteurs communs. Au cours de cette étude, les propriétés de liaison hydrogène et d'interaction hydrophobe ont été cartographiées sur la surface d'accessibilité au solvant de 14 molécules organiques sapides, afin d'identifier des motifs communs a plusieurs molécules, potentiellement complémentaires de certains sites récepteurs gustatifs. Dans ce but, les 14 molécules ont été découpées en 240 fragments, chacun possédant en moyenne 3 zones d'interactions potentielles. Un indice de correspondance à été défini pour évaluer l'analogie de deux fragments correctement superposés. Les 75 fragments les plus représentatifs des 14 molécules ont tous été superposés deux à deux. Le tri du résultat des 2775 comparaisons a permis de déterminer 12 groupes distincts de fragments. Ces 12 types de fragments ont été utilisés pour calculer des distances intermoléculaires structurales. Nous avons alors recherché la combinaison de fragments réalisant le meilleur accord entre les distances biologiques et les distances structurales. Le résultat final est un sous-ensemble de 7 types de fragments parmi les 12, rendant au mieux compte des distances intermoléculaires biologiques (p<0,001). Ces 7 types de fragments sont de bons candidats pour être complémentaires d'autant de sites récepteurs gustatifs distincts
8
Kaushanska, O. V. "Peculiarities of gout in patients with metabolic disorders." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18590.
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Léone-Robin, Isabelle. "Paul Gout (1852-1923), architecte du gouvernement et théoricien." Paris 4, 1993. http://www.theses.fr/1993PA040223.
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Elève de Jean-Charles Laisné et d’Anatole de Baudot, Paul Gout (1852-1923) fut architecte diocésain à Troyes, à Reims, à Soissons, à Vannes et à Paris et architecte des monuments historiques de 1879 à 1923. Il entreprit de nombreux travaux de restauration des édifices anciens du sud-ouest, de l'ouest et de l'est de la France. En 1898, il fut nommé architecte en chef des monuments historiques du Mont-Saint-Michel. Directeur de l'encyclopédie d'architecture, il rédigea de nombreux articles et il publia, en 1914, la première monographie consacrée à la vie et à l'œuvre de Viollet-le-DucPaul Gout (1852-1923), after studying under Jean-Charles Laisné and Anatole de Baudot, became a diocesan architect in Troyes, Reims, Soissons, Vannes, and Paris, and an architect of the historic buildings from 1879 to 1923. He undertook to restore a lot of old edifices in the south-west, the west and the east of France. In 1898, he was promoted to the rank of chief architect of the historic buildings at Mont-Saint-Michel (Normandy). As the manager of the encyclopaedia of architecture, he wrote many articles. And in 1914, he brought out the first monograph upon Viollet-le-Duc’s life and work
10
Bobkovych, K. O. "The ways of therapeutic optimization in patients with gout." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17088.
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Kuo, Chang-Fu. "Epidemiology of gout in the United Kingdom and Taiwan." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/27828/.
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Background: Gout is the most common inflammatory arthritis worldwide. The hallmarks of initial gout presentation are acute pain, swelling, erythema and tenderness in peripheral joints but eventually unremitting arthritis, joint deformity and tophus deposition may develop with long-standing hyperuricaemia. Patients with gout suffer not only arthritis but also cardiovascular, renal, metabolic and other comorbidities. Since gout is the consequence of chronic hyperuricaemia, urate-lowering treatments (ULT) helps prevent the formation of urate crystals and promote dissolution of existing crystals. Methods: This thesis contained results from a series of observational studies relating to gout. The data sources included the Clinical Practice Research Data-link in the UK and the National Health Insurance Database in Taiwan, both of which are representative of the general population in these two countries. Six different analyses were carried out: (1) epidemiology of gout in the UK (chapter 3); (2) epidemiology of gout in Taiwan (chapter 4); (3) Nature history of gout following diagnosis in the UK (chapter 5); (4) familial aggregation and heritability of gout in Taiwan (chapter 6); (5) risk of comorbidities occurring before gout diagnosis (chapter 7) and (6) Effects of allopurinol on all-cause mortality (chapter 8). Results: This study estimated that the prevalence of gout was 2.49% in the UK in 2012 and 6.24% in Taiwan. Incidence of gout was also higher in Taiwan (3.47 per 1,000 person years in 2010) than in the UK (1.77 per 1,000 person years in 2012). The prevalence and incidence were increasing in the UK in the past decade, however, both of which remained stable in the period 2005-2010 in Taiwan. Compared with the general population, individuals with a family history of gout had a two-fold increased risk of the disease. The relative contributions of heritability, shared and non-shared environmental factors to explain phenotypic variance of gout were 35.1%, 28.1% and 36.8% in men and 17.0%, 18.5% and 64.5% in women, respectively. Patients with gout were already at higher risk of multiple comorbidities at diagnosis, furthermore, gout was associated with higher all-cause mortality. In both countries, the management of gout remains poor. Most gout patients were eligible for ULT at diagnosis or shortly after. Allopurinol, the most commonly prescribed ULT in primary care in the UK, exerted a neutral effect on all-cause mortality, which reassures the safety of the drug in terms of all-cause mortality. Conclusions: Gout is the most common inflammatory arthritis affecting one in 40 people in the UK and one in 16 people in Taiwan. It is influenced by both environmental and genetic factors. Both incidence and prevalence keep rising in the UK whilst they remain comparatively stable in Taiwan. The management in the UK remains poor. Primary care physicians should be encouraged to screen for possible existing comorbidities at diagnosis. Most patients are eligible for ULT at diagnosis or shortly after diagnosis, and given the many benefits of ULT for gout patients, early discussion of ULT with patients seems reasonable practice. Allopurinol is not associated with heightened mortality which should reassure practitioners who avoid ULT for fear of serious adverse events.
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Séradin, Jean-Yves. "La politique de lecturisation au college : de l'habitus lectoral a la culture du desir de lire." Lyon 2, 1999. http://demeter.univ-lyon2.fr:8080/sdx/theses/lyon2/1999/jyseradin.
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Cette recherche sur la pedagogie de la lecture part d'une experience de lecturisation dans un petit college rural. Deux echantillons de lyceens sont opposes. Le premier, compose d'eleves qui ont participe a cette experience, le second, d'eleves qui ont connu une autre approche de l'ecrit lors de leur passage a ce niveau d'enseignement. 11 s'agit d'abord de distinguer parmi les trente jeunes interroges ceux qui sont des "lecteurs" et ceux qui ne le sont pas, les "liseurs". Cette opposition lecteur-liseur, qui s'observe aussi dans la diachronie, permet de depasser la polysemie du mot "lecture". Le lecteur dispose d'un habitus lectoral souvent impose par lente impregnation dans un milieu socio-culturel ou l'ecrit fait sens. La competence technique, celle qui autorise la lecture rapide de textes longs, s'est alors acquise a travers une pratique de lecture qui semble "naturelle". Les autres ont a construire cet habitus. L'ecole peut-elle les aider ? le recit de pratiques lectorales de ces lyceens s'appuie sur leur derniere lecture. Croisee avec les reponses a un questionnaire et un test de lecture, l'analyse de leurs propos permet non seulement de reperer les lecteurs et les liseurs, mais aussi de remonter par induction a l'habitus. Le travail sur l'habitus lectoral, necessaire, presente des limites et l'ecole ne peut compenser le "handicap" de ceux qui ne vivent pas deja dans la culture du scriptible. Les resultats observes incitent a resserrer le lien entre pratiques pedagogiques et horizon theorique. La politique de lecturisation pourrait se concevoir comme une praxis pedagogique. L'eleve, encourage a produire de l'ecrit, aide a theoriser une production fecondee par des lectures, entrerait dans une culture du desir de lire, non pensee comme une fin en soi, mais comme un moyen pour conquerir son autonomie. Cette pedagogie de la lecture implique une redefinition du role et de la formation du professeur de francais.
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García, Melchor Emma. "Gout as an autoinflammatory disease: from cellular to genetic mechanisms." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/283643.
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La gota ha estat classificada com a malaltia autoinflamatòria pel seu caràcter autolimitat i la participació del sistema immune innat i IL-1β en la seva patogènia. Durant els últims anys, l'evidència que els cristalls d'urat monosòdic (UMS) activen l'inflamasoma NLRP3, juntament amb l'eficàcia del tractament bloquejant de IL-1 en pacients gotosos, han reafirmat el concepte de gota com a malaltia autoinflamatòria. Tot i això, algunes preguntes relatives a la seva patogènia encara no tenen resposta. La presència de cristalls d'UMS en articulacions asimptomàtiques o el perquè no tots els pacients amb hiperuricèmia desenvolupen clínica de gota en són alguns exemples. En la present tesi hem centrat la nostra atenció en el sistema mononuclear fagocític amb la hipòtesi que l'estat d'activació o maduració dels monòcits i macròfags modula la resposta inflamatòria als cristalls d'UMS.
Pel que fa als macròfags, la nostra hipòtesi és que els macròfags residents, després d'entrar en contacte amb els cristalls, adquireixen un fenotip inflamatori, sent capaços de produir citocines inflamatòries en presència d'un segon estímul. Per a demostrar-ho, hem emprat un model in vitro de macròfags derivats de monòcits humans polaritzats cap a fenotips M1 o M2 en la presència de GM-CSF o M-CSF respectivament, considerant als M2 com a model de macròfags residents a la sinovial. Tant els macròfags M1 com els M2 foren incapaços de produir IL-1β després d'estimulació amb cristalls d'UMS o LPS. Però en presència de cristalls d'UMS, els macròfags M2 van secretar IL-1β, disminuint a més la seva producció de IL-10, en rebre un segon estímul amb LPS. Inesperadament, l'àcid úric soluble va exercir un efecte supressor en ambdues citocines. Els resultats dels nostres experiments demostren que la producció de IL-1β per part dels macròfags M2 s'explica perquè els cristalls d'UMS són capaços d'activar caspasa-1 a través de l'activació de l'inflamasoma, mentre que LPS indueix la producció de la forma inactiva de pro-IL-1β i caspasa-1. La nostra anàlisi de l'inflamasoma en macròfags M1 i M2 ha mostrat trets diferencials que podrien explicar els seus diferents requeriments per a la producció de IL-1β.
Per a investigar si una major reactivitat dels monòcits enfront dels cristalls d'UMS podria explicar perquè uns individus desenvolupen gota i d'altres no, vàrem comparar l'activació de l'inflamasoma en monòcits de pacients gotosos amb controls sans. Els monòcits de pacients gotosos presentaren una major activació de l'inflamasoma en presència dels cristalls d'UMS. Per tant, els nostres resultats suggereixen que els pacients amb gota presenten una major reactivitat enfront dels cristalls d'UMS. Per a completar l'estudi vam genotipar l'exó 3 del gen NLRP3, sense trobar associació de cap polimorfisme amb la gota. Finalment, vam analitzar la distribució de diferents subpoblacions de monòcits en sang perifèrica, observant una expansió dels monòcits amb fenotip intermedi (CD14++CD16+) en pacients durant un brot d'artritis gotosa, mentre que no varen existir diferències entre pacients gotosos asimptomàtics i controls sans.Gout has been classified as an autoinflammatory disease because of its self-remitting course and the involvement of the innate immune system and IL-1β in its pathogenesis. During the last years, the evidence of NLRP3 inflammasome activation by monosodium urate (MSU) crystals and the beneficial effect of IL-1 blockade for the treatment of patients with gout, have reaffirmed the concept of gout as an autoinflammatory disease. However, some questions regarding its pathogenesis remain still unanswered. The presence of MSU crystals in asymptomatic joints or why not all individuals with hyperuricemia develop clinical gout, are some examples. In this thesis we centred our attention in the mononuclear phagocyte system with the hypothesis that the state of activation or maturation of monocytes and macrophages modulates the inflammatory response to MSU crystals. Regarding macrophages, our hypothesis is that resident macrophages, after contact with MSU crystals, acquire an inflammatory phenotype, being able to produce inflammatory cytokines in the presence of a second signal or trigger. Therefore, to test it, we used an in vitro model of human monocyte-derived macrophages polarized towards M1 or M2 phenotypes in the presence of GM-CSF and M-CSF respectively, considering M2 macrophages a model of resident synovial macrophages. M1 and M2 macrophages failed to produce IL-1β after stimulation with MSU crystals or LPS. However, in the presence of MSU, M2 macrophages produced IL-1β and decreased IL-10 secretion when LPS was added. Surprisingly, soluble uric acid had a suppressive effect for expression of both cytokines. The production of IL-1β was explained because MSU crystals increased the presence of active caspase-1, reflecting inflammasome activation, whereas LPS induced pro-IL-1β and inactive caspase-1 production. Analysis of inflammasome activation in M1 and M2 macrophages revealed differences in inflammasome proteins, that could account for their different IL-1β production. To investigate if the capacity of monocytes to react to MSU crystals could explain why some individuals develop gout, we compared the inflammasome activation induced by MSU crystals in PBMCs from gouty patients with healthy controls. PBMCs of patients with gout exhibited enhanced inflammasome activation after culture with MSU. Therefore, our results suggest that patients with gout have an increased reactivity to MSU crystals. To provide further insight, we genotyped exon 3 of NLRP3 gene in gout patients, without finding any association of gout with polymorphisms in this gene. Finally, we analyzed the distribution of different monocyte phenotypes or blood subpopulations in patients with gout. We observed an expansion of the intermediate subpopulation (CD14++CD16+) during gout flares, but no differences were observed in any of the subpopulations between asymptomatic patients and healthy controls.
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Rai, Sharan Kimberly. "Population-based epidemiologic studies of gout in British Columbia, Canada." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59088.
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Introduction: This thesis contains original analyses aimed at better understanding the burden of gout, an excruciatingly painful form of inflammatory arthritis, in the Canadian context. While gout is increasingly recognized as the most common form of inflammatory arthritis worldwide (e.g., reported prevalence of 3.9% and 2.5% in the United States and United Kingdom, respectively), no Canadian trend data are available. Objectives: 1) To evaluate the contemporary prevalence and incidence of gout over the past decade, as well as gout treatment patterns and comorbidity burden. 2) To evaluate the burden of hospitalized gout and corresponding inpatient costs as compared to rheumatoid arthritis (RA), another inflammatory joint disease known to incur substantial resource use. Methods: To address both objectives, I used PopulationData BC, a large administrative database spanning the province of British Columbia (BC). For Objective 1, I used physician and hospital visits to identify gout cases and estimate the annual trends in prevalence and incidence among the general population. I additionally used data from PharmaNet, BC’s prescription drug database, to examine gout treatment patterns (i.e., urate-lowering therapy, colchicine, glucocorticoids, and non-steroidal anti-inflammatory drugs) over the same time period. For Objective 2, I used hospital diagnoses and procedure codes to assess annual trends in hospitalizations and joint surgeries as well as inpatient costs for both gout and RA. Results: 1) Both the prevalence and incidence of gout have increased over the past decade (i.e., a 59% and 48% increase, respectively), while the prescription of gout treatment remains low. 2) The hospitalization rates for gout have doubled over the past decade, while those for RA have declined by 49%. The inpatient costs also reflected the hospitalization trends, with a 40% decrease in RA hospital costs, while gout costs more than doubled over the study period. Conclusion: Altogether, this thesis provides evidence that the burden of gout in Canada is substantial and increasing. These findings are further contrasted against the hospitalization burden of RA, which has decreased considerably over the same period. This thesis highlights the critical need to improve gout prevention and care to mitigate its rising disease burden in Canada and beyond.Medicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate
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Kratzer, James Timothy. "Reengineering a human-like uricase for the treatment of gout." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52149.
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There is an unmet medical need in the treatment of gout. This type of inflammatory arthritis can be efficiently alleviated by the enzyme uricase. This enzyme breaks down uric acid, the causative agent of gout, so it can be flushed from the body. In humans and the other great apes, uricase is a pseudogene and as such is inactive. Research on therapeutic uricases has focused on using enzymes from naturally occurring sources; however, these foreign proteins can be very antigenic and present a potentially life-threatening safety risk to patients. We address the challenges of developing a safer uricase therapeutic by exploiting evidence that, while inactive, the human pseudogene is expressed in the human body and may be recognized as self by the immune system. To develop a ﾓhuman-likeﾔ? uricase we apply the hybrid computational and experimental approach of Ancestral Sequence Reconstruction to search functional sequence space of uricase proteins to engineer an enzyme with high sequence identity to the human pseudogene, and possessing therapeutic levels of activity for the breakdown of uric acid. This dissertation describes the development and characterization of several uricase leads. The most active ancestral uricase possesses both enhanced in vitro and in vivo stability (in healthy rats) when assayed head-to-head Pegloticase, the only FDA approved uricase for the treatment of gout.
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Berger, Anne-Emmanuelle. "Gout et degout de la beaute dans l'oeuvre de rimbaud." Paris 8, 1990. http://www.theses.fr/1990PA080504.
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C'est dans son rapport polemique a l'ideologie esthetique prevalant dans le champ poetique a l'epoque ou il se met a ecrire, que nou analysons les termes ambivalents de la relation de rimbaud a la "beaute", c'est-a-dire a la poesie elle-meme, telle qu'elle se represente et s'exalte en son allegorie. Pour comprendre les enjeux de son gout degout de la beaute, nous avons recu les theoriciens de l'esthetique (aristote, kant, hegel) et leurs critiques (nietzsche, adorno, derrida). Telle que la decrit le prologue d'une saison en enfer, l'approche rimbaldienne de la beaute nous apparait comme une volonte d'en "sentir" le "corps", opposee radicalement a la demarche idealiste qui domine dans la pratique poetique de son temps. La traduction par le poete de l7insucces de son entreprise en termes d'experience negative de la bouche (la "beaute" s'avere litteralemeht "amere") nous invite a reflechir a ce qui lie l'experience esthetique et l'oralite, et, plus specifiquement, au rapport que l'exercice de la poesie entretient avec la recherche d'une satisfaction orale. En cherchant a retrouver dans et par la poesie le gout du "festin ancien", rimbaud reve peut-etre de "desublimer" les pulsions et les desirs a l'oeuvre dans l'activite lyriqueIt is in polemical stance toward the aesthetic ideology prevailing in the poetic realm at the time when he starts writing that i analyse the ambivalent terms of rimbaud's relation to "beauty", which is to say to poetry itself, as it represents ans celebrates itself in its allegory. In order to better understand what is at stake in his taste distate of beauty, i have reread the theoreticians of aesthetics (aristotle, kant, hegel) and their critics (nietzsche, adorno, derrida). As the prologue of une saison en enfer describes it, rimbaud's approach to beauty appears as a will to "sense" its "body", radically opposed to the idealism of poetic practice of the time. The translation by the poet of the failure of his endeavor in terms of a negative experience of the mouth ("beauty" is found literally "bitter") invites us to reflect on what links the esthetic experience to orality and more specifically on the relationship between the practice of poetry, in contrast to other linguistic activities, and the search for an oral feast" within and through poetry, one could say that rimbaud dreamed the "desublimation" of the desires and drives at work in the lyric
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Dogolich, O. I. "Сardiovascular risk as a comorbidity phenomenon in patients with gout." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19561.
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Hall, Mandy. "Investigation of pathological biomineralisation using Raman microscopy." Thesis, Northumbria University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384965.
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贾博慧. "痛风性关节炎的中医治疗文献研究." HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/135.
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一.背景 痛风性关节炎，属于中医“痹证”“白虎历节风”“痛风”范畴。是以高尿酸血症为生化基础，继发尿酸盐结晶沉积、关节损害、结石形成所致的急慢性关节炎，表现为关节红、肿，疼如刀绞，痛剧难忍，亦可自行缓解，常发作无常，来去如风，故名痛风，是痛风病的中、后期阶段。严重者可造成骨质破坏、关节畸形。 本病受遗传、环境和饮食习惯的影响，患病率逐年增加。现代医学治疗本病，急性期以控制症状，减轻痛苦；缓解期以降低高尿酸血症为目标，尚无根治方法；况且所用药物均有较大的毒副反应，使本病的治疗处于窘境。中医中“痛风”之名始於金元，由朱丹溪首先提出，并设专篇论述，其在〈格致余论－痛风〉中指出“痛风者，四肢百节走痛，书中谓之白虎历节风证是也”“大率因血受热，已自沸腾，其后或涉冷水，或立湿地，或扇风取凉，或卧地当风，寒凉外搏，热血得寒，污浊凝瑟所以作痛，夜则痛甚，行于阴也”。其发病以脾肾两虚为本，湿、 热、毒、为标，热毒重可生湿，湿邪盛能化热，内毒流窜经络，攻注骨节，着于经脉，终致湿热毒交互为患，证属正虚邪实。近年来中医药对痛风研究逐渐深入，主要为中药汤剂的研究较为广泛，关于针灸、推拿、拔罐等中医传统特色治疗研究逐步开展，并取得可喜成绩。 二．目的 本次研究拟通过对现有关于痛风性关节炎中医手段治疗的临床研究类文献和实、验研究类文献的搜集、整理、分析，从而对痛风性关节炎中医治疗手段的临床有效率进行统计，并对痛风性关节炎中医治疗手段的改进与发展进行探讨。 三．万法 本論文文献资料来源：中国期刊全文数据库（CNKI）。通过对中国期刊全文数据庫库（CNKI）进行标准检索，方法为：计算机检索2005年－2015年国内外关于痛风性关节炎的中医治疗文献，搜素关键宇：痛风性关节，并包含中医、中药、针刺 、针灸， gout 、gouty arthritis。 经过文章检索方法的纳入与排除，得到所研究的文献。 四,結果 搜索中医治疗痛风性关节炎综遮类文献356篇；中药类治疗文献493篇，其中中药内用临床研究类文献317篇、中药内用实验研究类文献176 篇、中药外敷类研究文献79篇；针刺、针灸类治疗研究文献183篇，排除重复19篇，剩余共计164篇。经纳入和排除后，共得可用文献145篇，其中痛风性关节炎证候分型、辩证论治类21篇，中药、针刺等各法临床类研究文献83篇，实验类研究文献4l篇。 在文献分析过程中得出结果：1.痛风性关节炎的证型为：湿热蕴结型、淤热阻滞型、痰浊阻滞型、肺气虚弱型、肝肾阴虚型等。2. 病情分期为：急性期、静止期、慢性期。3.（统计排位前三）中药内用常用方剂为：四妙九、上中下痛风汤、二陈汤；常用中药为：薏苡仁、黄柏、牛膝；常用药物类为：通络止痛类、清热燥湿解毒类、利湿化浊类；常用药对为：茯苓与薏苡仁、苍术与黄柏、山栀与黄柏；常用针刺术穴位：曲池、血海、三阴交。 研究文献中所有中医临床治疗方法均对痛风性失节炎有效，作用率100% 。并无毒、副作用。 五, 结论 中医治疗对于痛风性关节炎有良好的综合性治疗效果，强于口服西药。
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ARLES, CLAUDE. "Le gout, le culinaire et le rapport a l'objet alimentaire : etude phenomenologique, anthropologique et psychanalytique." Lyon 1, 1994. http://www.theses.fr/1994LYO1M062.
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DAURAT, DIDIER. "Effets d'une prise unique de yohimbine sur l'alliesthesie olfacto-gustative chez le volontaire sain." Toulouse 3, 1992. http://www.theses.fr/1992TOU31104.
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Anselme, Christophe. "Etude et caracterisation des problemes de mauvais gout de l'eau potable." Paris 7, 1987. http://www.theses.fr/1987PA077178.
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Kopke, Amy. "The effect of acute gout on inflammatory markers in hyperuricemic patients." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24910.
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Introduction: Gout is a painful form of acute inflammatory arthritis associated with elevated uric acid crystal deposition especially in the joints, but also in tendons and the kidney. Between 1 and 2% of Western populations are affected and in severe cases, gout sufferers can be completely incapacitated. Despite the number of gout sufferers, the high number of risk factors and high incidence of adverse drug reactions using the standard treatment regimens, little research involving gout has been done within the highly diverse multiracial and multicultural population of South Africa. Hypothesis: This study was a hypothesis generating observational study to assess whether serum levels of pro-inflammatory cytokines and acute phase protein levels could be used as markers of the gout status of a patient. Method: Thirty gout patients were enrolled onto the study and attended two visits. At the screening visit; medical history, vital signs and demographic details were collected from intercritical gout patients. At both visits, patients completed visual analogue scales; namely: subject’s assessment of pain and subject’s assessment of disease activity. A doctor completed the physician’s assessment of disease activity at both of the visits. At the end visit, patients experiencing an acute gout attack were asked to list various foods and beverages that triggered said attacks. Patients were requested to return for their second visit as soon as they experienced a gout attack, however, those patients that did not experience a gout attack were asked to return to the clinic to complete the follow up visit four months after their baseline visit. Uric acid, IL-1β, TNF-α and CRP were measured for each patient at both visits. Results: Many of the patients displayed risk factors for metabolic syndrome. The mean subject’s assessment of pain score increased from 31mm at the screening visit to 40mm at the end visit (p=0.1947; n=26), while the mean subject’s assessment of disease activity score and the mean physician’s assessment of disease activity increased from 30mm to 37mm (p=0.3196; n=26) and 23mm to 35 mm (p=0.0937; n=26) respectively. Uric acid levels decreased from 1.053mmol/L to 0.871mmol/L between visits (p=0.0926; n=25) while CRP concentrations increased significantly from 10.2mg/L to 26.6mg/L (p=0.0278, n=24). IL-1β concentrations remained similar (12.17pg/ml to 12.54pg/ml) while TNF-α concentrations decreased from 12.63pg/ml to 3.54pg/ml, however neither of these were statistically significant differences. Upon stratifying results into active and non-active patients, both IL-1β and TNF-α concentrations decreased between non-active and active patients, while CRP and urate concentrations increased. However, none of these differences were statistically significant. Conclusion: The visual analogue scales all showed an increase between the screening and final visits, although this was not statistically significant. Uric acid concentrations decreased between visits, however this increase was once again not statistically significant. There appears to be no association between inflammatory markers and the level of gout activity, although this needs to be tested in a larger sample population. Results in South African patients have confirmed results from previous studies where gout patients are at a higher risk of metabolic syndrome than the normal population. CopyrightDissertation (MSc)--University of Pretoria, 2011.
Pharmacology
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Miller, Kelly. "Improving the Evidence Based Diagnosis of Gout in the Primary Care Setting." Thesis, State University of New York at Binghamton, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10281524.
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Although gout is the most prevalent form of inflammatory arthritis, its diagnosis can be complex. To meet the gold standard for diagnosis, providers need to perform a joint aspiration and identify the presence of monosodium urate crystals (MSU) in the synovial fluid or from tophi, a challenging skill in the primary care setting. In its absence, patients have to meet several criteria before a diagnosis can be made. Not surprisingly, gout has been inconsistently diagnosed by Primary Care Providers (PCPs). Thus in 2015, the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) worked collaboratively to develop a new set of clinical criteria for the diagnosis of gout.
For this Doctor of Nursing Practice (DNP) Capstone Project, a review of the literature was conducted using the Chronic Care Model (CCM) as a guide to examine the evidence regarding the use of clinical guidelines for the diagnosis of gout in the primary care setting. Using a pretest-posttest reflexive control design, chart abstraction was performed and, subsequently, an educational session was conducted to see if a short learning lunch would increase PCP knowledge and documentation in the medical record related to use of the 2015 ACR/EULAR diagnostic criteria.
A total of 36 PCPs from six different primary care settings participated. Chart abstraction revealed that only 31 out of the 54 charts (57%) had adequate documentation to support a diagnosis of gout. A statistically significant improvement in knowledge was demonstrated for several domains of the diagnostic criteria at the posttest. Results from this project indicated that a short learning lunch was effective for increasing PCP knowledge of the 2015 ACR/EULAR gout classification criteria. Through clinical support, easier access to updated evidence based clinical guidelines, and continuing education, PCPs acquired new knowledge and skills essential for providing evidence-based, quality care to their patients.
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Reinders, Mattheus Karsien. "Practice research in the field of gout clinical pharmacology of antihyperuricemic drugs /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
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Сміян, С. І., and О. В. Соліляк. "Частота виявлення ожиріння у хворих подагрою." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35695.
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Ожиріння є патологічним станом який ускладнює перебіг багатьох захворювань. Яскравим прикладом цього є подагра.
При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/35695
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Liu, Xiao. "The role of monocytes in gouty arthritis : a thesis submitted to the Victoria University of Wellington in fulfilment of the requirements for the degree of Master of Science in Biomedical Science /." ResearchArchive@Victoria e-thesis, 2009. http://hdl.handle.net/10063/984.
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Survepalli, David George. "Foot and ankle characteristics in patients with chronic Gout: a case controlled study." AUT University, 2009. http://hdl.handle.net/10292/973.
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Introduction: Gout affects approximately 15% of Maori and Pacific men, these men being at risk of early onset, severe disease with formation of gouty tophi and joint damage. Gout most frequently affects the foot, particularly the big toe and midfoot. This disease initially presents as self-limiting attacks of severe joint inflammation, and in the presence of persistent hyperuricaemia, tophaceous disease may also develop. Tophi are collections of monosodium urate crystals surrounded by chronic inflammatory cells and connective tissue. Tophi typically occur in both subcutaneous tissues and within affected joints, and may cause pain, cosmetic problems, mechanical obstruction of joint movement, and joint destruction. Despite the predilection of gout to the foot, the impact of gout on foot function is currently unknown and only case studies relating to hallux pain, tibial sesamoid pain and longitudinal tears in peroneal tendons have been reported in the literature. The aim of this study is to assess the intra-tester reliability of certain biomechanical tests to evaluate foot structure and function (plantar pressure measurements, gait parameters, range of motion at the ankle and first MTPJ and the foot posture index) in individuals with gout and to assess the differences between disability, impairment, foot structure and function between individuals with gout and non-gout controls. Subjects: A total of 25 patients with chronic gout with a mean age of 61.2 (11.7) years old were recruited from a rheumatology clinic within the Auckland District Health Board. A further 25 age-and sex-matched controls with a mean age of 57.3 (12.2) years old were recruited from AUT University. Methods: Disability, impairment, foot structure and foot function were assessed for the gout and the control group. Disability and impairment was assessed using the Health Assessment Questionnaire, Foot Function Index, Leeds Foot Impact Scale and Lower Limb Task Questionnaire. Foot structure was investigated using the Foot Posture Index, first metatarsophangeal joint (MTPJ) dorsiflexion, ankle dorsiflexion movement, subtalar joint and midtarsal joint motion, Foot Problem Score, tophi count and muscle strength of extrinsic and intrinsic foot muscles. Foot function was investigated using an in-shoe pressure system measuring mean peak plantar pressures and pressure-time integrals. Temporal-spatial gait parameters were evaluated, as well as peripheral sensation and vibration perception threshold. Plantar pressures were assessed using the Tekscan pressure insole system, gait parameters were measured using the Gaitmat walkway system, peripheral sensation and vibration threshold were assessed using 10gm monofilament and biothesiometer respectively. Intra-tester reliability was investigated using ICC, Standard Error of Measurement and Smallest Real Difference in the gout group for key measures (Foot Posture Index, first MTPJ dorsiflexion, ankle dorsiflexion movement, peak plantar pressures, pressure-time integrals and gait parameters). To investigate the significant difference between the groups, the left and right foot in gout were compared with the left foot of the control group using ANOVA with post-hoc comparisons. Non-parametric tests were used for muscle strength, peripheral sensation and Foot Problem Score and motion at the subtalar and midtarsal joints for comparison between the groups. Walking velocity, cadence and disability and impairment scores between the groups were assessed using an independent t-test with 95% confidence intervals. Significance for all these measures was set to 0.05 except for Chi square where a significance of 0.02 was set. Results: The ICC for the intra-tester reliability was excellent with low measurement error for the measured outcomes. The gout group recorded significantly higher disability and impairment scores than controls (p<0.01). Significant differences between the two groups were recorded for vibration pressure threshold, muscle strength, Foot Problem Score, first MTPJ dorsiflexion, foot motion and gait parameters (p<0.05). Significant differences were demonstrated under the toes for mean plantar pressures and under the lateral heel, midfoot and hallux regions for pressure-time integrals in the gout cases (p<0.05). Conclusions: Individuals with gout have reduced quality of life due to greater disability and impairment. The gouty foot is slightly supinated with reduced dorsiflexion at the first MTPJ. Rearfoot and forefoot motions are limited with a high incidence of digital deformities and dermatological lesions. The foot function in gout is characterized by reduced walking velocity, cadence, step and stride length. The plantar pressures are reduced under the toes with increased duration of loading under the hallux, lateral heel and midfoot regions. Further research using three-dimensional gait analysis is recommended to quantify motion at the foot and ankle joints and also to ascertain the role of proximal joints. Future work could be undertaken to evaluate the impact of acute gout on objective measures of foot function, and to determine predictors of poor foot function in patients with this disease. This will allow further work to investigate or formulate a podiatric management plan in conjunction with pharmacological therapy to improve impairment, disability and function in chronic gout.
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Орловський, Олександр Вікторович, Александр Викторович Орловский, Oleksandr Viktorovych Orlovskyi, М. М. Шаповал, and А. В. Шищук. "Рівні С-реактивного білка та швидкості осідання еритроцитів у хворих на подагру із супутнім метаболічним синдромом." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35734.
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Sorin, Catherine, and Pierre Sorin. "Trouble du goût et carence en zinc chez le sujet âgé : essai d'une supplémentation chez vingt trois sujets âgés." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M079.
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Chandratre, Priyanka Narendra. "Health-related quality of life in gout : a primary care-based mixed methods study." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2369/.
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Background: Gout is the most prevalent inflammatory arthritis (2.5%) and may affect Health Related Quality Of Life (HRQOL) through its disease features, associated co‐morbid and sociodemographic characteristics. Methods: A systematic review of HRQOL in gout and the instruments used to measure it was performed. 1805 eligible patients in primary care were mailed a questionnaire to ascertain selfreported HRQOL (measured using Health Assessment Questionnaire Disability Index (HAQ‐DI), Short‐Form 36 Physical Function subscale (PF‐10) and Gout Impact Scale (GIS)), gout, co‐morbid and socio‐demographic characteristics. Univariate unadjusted (T‐test and analysis of variance) and multivariate adjusted (linear regression models) associations between HRQOL and independent variables were examined. Focus group interviews of participants’ perspectives towards gout and its treatments affecting HRQOL were conducted and thematic analysis performed. Results: 22 studies in the systematic review identified poor physical HRQOL in those with gout and co‐morbidities. Existing studies were limited by use of either generic or gout‐specific HRQOL questionnaires and mostly secondary care settings. 1184 completed questionnaires were received (response 65.5%). On multivariate adjusted analysis, worse generic and gout‐specific HRQOL was associated with higher attack frequency, history of oligo/polyarticular attacks, allopurinol, body pain, depression, alcohol consumption and age. HRQOL measured using the GIS only was associated with serum uric acid >360μmol/L and currently having an attack and using the PF‐10 and HAQ‐DI only with female gender, stroke and angina. The key themes arising from the qualitative interviews were the impact of gout characteristics, misunderstanding of gout and lack of information from physicians. Conclusions: HRQOL in gout is affected by disease severity, medical and psychological comorbidities and socio‐demographic characteristics. Urate‐lowering treatment should be initiated early to prevent disease progression. Co‐morbidities should be screened for and treated alongside gout. Factors associated with HRQOL differ according to the instrument used and the choice of instrument will depend upon the objectives of future research studies.
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Franco, Bernard. "Le despotisme du gout. Debats sur le modele tragique allemand en france, 1797-1814." Paris 4, 1997. http://www.theses.fr/1997PA040277.
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Apres l'echec du modele shakespearien au xviiie siecle, le systeme tragique francais cherche de nouvelles voies pour se renouveler. La reception en france de la critique de lessing, l'entreprise du nouveau theatre allemand, la place de schiller dans les adaptations melodramatiques avaient amorce un mouvement. L'emigration l'amplifie par une connaissance approfondie de la culture allemande, et des journaux d'emigres, surtout a partir de 1797, favorisent la diffusion de la litterature allemande en france. Dans ce contexte, le role de mme de stael, et, autour d'elle, du groupe de coppet, est fondamental. Le debat esthetique prend alors une dimension politique (de l'allemagne n'a pu paraitre en france qu'en 1814) et la critique de l'empire, defendant la tragedie classique, rejette tout modele etranger. Contre l'argument du gout defendu par la critique neo-classique, le groupe de coppet introduit, par l'apport d'a. W. Schlegel, les concepts de la critique romantique allemande : le genie createur est oppose a l'imitation de modeles anachroniques, et la critique, qui ne doit pas en rester a l'analyse exterieure des formes mais rechercher le centre vital de l'oeuvre, est elle-meme erigee en creation. C'est dans ce contexte que doit se comprendre le passage des theories aux realisations : les adaptations de pieces allemandes, mises a l'epreuve des theories, sont cependant decevantes. Marquees par la presence du schema classique ou melodramatique, elles presentent un decalage considerable par rapport aux conceptions dramatiques dont elles sont issuesAfter the failure of the shakespearian model in the eighteenth century, the french tragic system looks for new means of self-renewal. The reception in france of the criticism of lessing, the nouveau theatre allemand project, schiller's place in the melodramatic adaptations had triggered a trend. Emigration amplifies this movement by enabling a thorough awareness of german culture, and the expatriates' periodicals, especially from 1797 onwards, encourage the diffusion of german literature in france. In this context, the role of mme de stael and the coppet group is fundamental. The aesthetical debate then acquires a political dimension (de l'allemagne could only be published in france in 1814) and empire criticism, which defends classical tragedy, rejects all foreign models. Against the argument of taste defended by neo-classical criticism, the coppet group, inspired by a. W. Schlegel, introduces the concepts of german romantic criticism: the creative genius is set against the imitation of anachronistic models, and criticism, which must go beyond the superficial analysis of form and discover the living centre of the work, is itself set up as creation. It is in this context that the passage from theory to realization must be understood: the adaptations of german plays, testing-ground for the theories, are however disappointing. Bearing the mark of the classical or melodramatic scheme, they present a considerable discrepancy with regard to the dramatical conceptions of which they are the fruit
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Smiyan, S. I., S. V. Danchak, and U. S. Slaba. "The role of antioxidant protection in patients with gout combined with functional liver disorder." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35768.
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Gout is an inflammatory arthritis characterized by excruciating painful acute attacks. The frequent use of nonsteroidal anti-inflammatory drugs, that takes place in patients with gout, leads to lesion of the gastrointestinal tract including the liver. One of the main mechanisms of pathological changes in liver tissue is the disruption of free radical oxidation of lipids. Antioxidant system in the human body works by decreasing the effects of the free radicals that forms in the affected tissues in combination with liver disease.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35768
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Martin, William John. "Cellular inflammation in models of acute gout : a thesis submitted to the Victoria University of Wellington in fulfilment of the requirements for the degree of Doctor of Philosophy in Cellular Biology /." ResearchArchive@Victoria e-Thesis, 2008. http://hdl.handle.net/10063/896.
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Li, Lingyi. "Trends of venous thromboembolism risk before and after diagnosis of gout : a population-based study." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63308.
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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.Medicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate
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MEYER, CHRISTOPHE. "Bases moleculaires du gout sucre : flexibilite conformationnelle et relations structure-activite d'edulcorants intenses derives du saccharose." Nantes, 1994. http://www.theses.fr/1994NANT2079.
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Cette these s'inscrit dans le cadre general de l'elucidation des bases moleculaires responsables de l'activite sucree. Les travaux entrepris representent notre contribution a la caracterisation du comportement conformationnel et des relations existant entre la structure et l'activite d'edulcorants intenses derives du saccharose. Ils mettent en uvre des outils largement employes dans le domaine de la modelisation moleculaire tels que methodes de mecanique moleculaire et quantique, algorithmes de calcul theorique de grandeurs experimentales et outils statistiques d'analyse des donnees appliquee a la chimie. Un ensemble de parametres adaptes a la modelisation des glucides a d'abord ete developpe afin de completer le champ de force tripos. La reproduction des structures et du comportement conformationnel d'exemples documentes de glucides valide ces parametres qui ont ete utilises tout au long de cette etude. Deux analyses conformationnelles, confrontees aux donnees de rmn, montrent que les molecules de saccharose et de tgs (trichloro-galacto-saccharose) sont des molecules flexibles qui adoptent des conformations privilegiees en solution. La determination du comportement conformationnel de ce type de molecule constitue un prealable necessaire a toute etude de relation structure-activite. Finalement, une etude de relation structure-activite (qsar) a ete conduite sur une famille de derives halogenes du saccharose. Le glycophore et les proprietes essentielles pour l'activite sucree de ces molecules ont ete clairement precises et un modele tridimensionnel predictif de cette activite a ete propose
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Paraniuk, Yu D., and Ludmyla Viktorivna Mikulets. "Specific characteristics of the daily monitoring of the blood pressure in patients suffering from primary gout." Thesis, Материалы 70-й научной конференции студентов-медиков с международным участием "Актуальные проблемы современной медицинской науки": (Узбекистан, г. Самарканд, 27.05.2016 г.). – г. Самарканд: Изд. СамГМИ, 2016, 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10961.
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Circadian blood pressure changes were detected in the patients afflicted with gout at daily monitoring of the blood pressure conduction even in the patients without arterial hypertension clinical manifestations. Disorders of daily blood pressure rhythms are additional risk factors of cardiovascular diseases. In order to prevent cardiovascular catastrophes and to reveal the insidious arterial hypertension in the patients suffering from gout it is necessary purposeful cardiological examination.Кафедра пропедевтики внутрішніх хвороб
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Hobson, Biano. "Objective and subjective assessment of chronic disease management in General Practice. To determine the standard of care provided in the management of asthma, gout and hypothyroidism by means of a medical audit." Thesis, Stellenbosch : University of Stellenbosch, 2015. http://hdl.handle.net/10019.1/97247.
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Asthma, gout and hypothyroidism are common chronic medical disorders encountered in general practice. Optimal disease management according to standard guidelines are fundamental to disease control. This study aimed to objectively and subjectively assess the quality of care provided in a private general practice to patients with asthma, gout and hypothyroidism by means of a practice audit and questionnaire based survey. These tools proved to be an effective measure for the quality of care provided and identified areas needing improvement. Patient’s understanding of the disease process plays an important role in both patient satisfaction ratings and success of disease control. The medical audit identified and highlighted specific areas of care that can be improved. Evidence from the practice audit showed that control for asthma based on the PEFR readings, gout based on the serum uric acid reading and hypothyroidism based on a blood TSH reading, was found at 56.7%, 43.3%, and 66.7 % respectively. In addition acute attacks of asthma and gout occurred in 22.7% and 32.8% respectively. This does not represent good control. Definition of disease control for each condition is placed in the text. The survey revealed overall patient understanding for the disease processes of asthma, gout and hypothyroidism to be 69.6%, 73.3% and 66.8% respectively. The patient survey satisfaction rating for asthma, gout and hypothyroidism was 93.1%, 93.9% and 89.2% respectively. Patient suggestions for improvement included three dominant themes: better assessment of disease control, education about their chronic disease and implementation of a clearer referral process. The study concludes that disease control can be achieved if patients are educated about their chronic disease and regularly followed up to assess disease control based on standard management guidelines. Patients' disease education was a major contributing factor for satisfaction rating bias. The study confirms that in spite of high satisfaction ratings, patients are not optimally managed with substandard disease control. It would be expected that as disease education improves, the quality of care will improve, but satisfaction ratings will decrease.
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Орловський, Олександр Вікторович, Александр Викторович Орловский, Oleksandr Viktorovych Orlovskyi, Ю. І. Скоропад, and Ю. М. Сусол. "Поширеність метаболічного синдрому у хворих на подагру." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35698.
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Тяжкий перебіг хвороби майже у 2 рази частіше спостерігався у хворих із супутнім МС. Поряд із тим у хворих на МС констатовано більш ранній початок захворювання (в середньому 6,5 років), артеріальна гіпертензія у 2 рази частіше, на 50 % частіше виявляли тофусну подагру і достовірно вищий рівень сечової кислоти.
При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/35698
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Frakes, Stephanie L. "Chopin's Cantabile in Context." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357332093.
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Stöhr, Katharina [Verfasser], and Michael [Gutachter] Lell. "Dual-energy computed tomography in the diagnosis and treatment monitoring of gout / Katharina Stöhr. Gutachter: Michael Lell." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2016. http://d-nb.info/1112326804/34.
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Петрик, Е. В., and В. Б. Овсий. "Метафилактика больных подагрой, осложненной нефропатией и мочекаменной болезнью." Thesis, Сумский государственный университет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32524.
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В последние годы в мире отмечается тенденция к увеличению заболеваемости подагрой. В Украине она составляет 0,2% населения, а в США и Европе около 2%.
При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/32524
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Li, Bolan. "Raman Spectroscopic Analysis of Crystals in Synovial Fluid." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1457709368.
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Clarson, Lorna Elise. "Risk of incident vascular disease in patients with gout : an observational study in the Clinical Practice Research Datalink." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2309/.
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Gout is the most prevalent inflammatory arthritis, predominantly managed in primary care. Both hyperuricaemia (the biochemical precursor to gout) and other inflammatory arthritides, e.g. rheumatoid arthritis, have been shown to increase risk of vascular disease. This thesis aims to investigate the risk of incident cardiovascular, cerebrovascular and peripheral vascular disease in primary care gout patients. A systematic review identified 17 studies investigating gout and vascular diseases. Meta-analysis showed increased mortality from all cardiovascular and coronary heart disease. Increased incidence of, but not mortality from myocardial infarction was found. Few studies investigated the association between gout and cerebrovascular or peripheral vascular disease. A retrospective cohort study used data from the Clinical Practice Research Datalink to examine the risk of incident cardiovascular, cerebrovascular and peripheral vascular disease in 8386 gout patients and 39766 age-, gender- and practice-matched controls, in the ten years following diagnosis of gout (or matched date) using Cox proportional hazards and multilevel discrete-time event history analysis. Risk was also investigated by gender and with follow-up limited to one, two and five years. The effect of exposure to drugs used to treat both gout and vascular risk factors on the magnitude of risk was examined using a cohort and nested case-control study design. The strongest association identified was between gout and peripheral vascular disease. Women with gout had the greatest excess vascular risk and experienced a wider range of vascular events. Exposure to drugs used to manage vascular risk factors was associated with increased likelihood of a vascular event, but use of gout treatments such as allopurinol did not influence incident vascular risk. This suggests that gout patients, particularly women, should have screening for and aggressive management of vascular risk factors, although as conventional approaches may be insufficient, further research is required to establish the optimum risk reduction strategy.
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Cara, Raakhi. "Homoeopathic treatment in acute gout." Thesis, 2012. http://hdl.handle.net/10210/5866.
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M.Tech.This research was conducted to determine the effect of homoeopathic treatment on acute gout patients. Putterman (1994) conducted a research study on the effect of the homoeopathic remedy Colchicum autumnale in gout, and found partial improvement in the clinical picture of gout. No research has been conducted in South Africa on the efficacy of homoeopathic medicines in acute gout patients. This study focused on the homoeopathic Law of Similars, where a single most similar homoeopathic remedy was chosen according to the unique characteristic symptoms displayed by each participant suffering with acute gout. This was a qualitative study that used ten subjects who presented within five days of acute gout and participated in the fifteen-day study period. Participants that complied with the American College of Rheumatology (formerly American Rheumatism Association, ACR) criteria for gout were selected. Serum uric acid tests were taken on day 0 and day 6 to assess hyperuricemia. On day 0 a thorough case history and examination was taken followed by administration of the indicated remedy. Treatment efficacy was evaluated on day 1, 3 and 6, based on daily subjective impression of participant involvement, objective analysis and comparative analysis of serum uric acid. Re-examination for relapses or rebound attacks followed on day 15. In a study using allopathic remedies in acute gout, resolution of all acute gout symptoms occurred at an average of 8 days using indomethacin and 7 days using triamcinolone (Alloway et. al., 1993). In this study using homoeopathic similimum treatment, resolution of all acute gout symptoms occurred at an average of 6 days. One episode of a rebound gout attack occurred and serum uric acid decreased in 80% of patients. Homoeopathic similimum prescribing is an effective alternative treatment for acute gout. Although more research is required, the preliminary findings of this study suggest that the correct homoeopathic similimum treatment is an effective treatment for the symptoms of acute gout.
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Wu, Chien-hsing, and 吳建興. "The Relationship between Urinary Uromodulin Excretion and Chronic Kidney Disease in Gout and Non-Gout Patients." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/00543587013597875855.
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碩士國立中山大學
生物科學系研究所
101
INTRODUCTION AND AIMS: Gout is a popular disease worldwide. Traditionally, patients suffering from gout were thought to be at high risk for renal complications and people who had gout always worry about the potential risks of getting a kidney disease. The link between uromodulin (UMOD) and chronic kidney disease (CKD) has attracted much interests in the medical literature and several investigations showed UMOD had active role in CKD progression. To our knowledge, the association of urinary UMOD excretion on gout and non-gout patients with CKD has not been thoroughly investigated. METHODS: A total of 114 Taiwanese patients with stable disease activity selected from a cohort that attended our renal and rheumatology outpatient department were enrolled (Non-Gout patients: 40 ,Gout patients: 74) between Jun. 1, 2011 and Dec. 13, 2012. Patients were divided into CKD group (N=68) and non-CKD (N=46) group. CKD was defined by MDRD equation estimate glomerular filtration rate (eGFR)＜60 ml/min per 1.73m2. Their demographic data, laboratory tests including serum creatinine, serum uric acid eGFR, and urinary creatinine and UMOD level were measured. Urinary UMOD excretion was calculated as UMOD/UCR ratio. RESULTS: Using Pearson correlation analysis, urinary UMOD excretion correlated positively with eGFR in patients with Gout. In non-gout patients, urinary UMOD excretion does not correlate with eGFR. Gender, status of DM, gout and hypertension do not show significant difference between CKD group and non-CKD group. However, age (CKD group: 62.2 ± 13.8, Non-CKD group: 43.9 ± 12.8, p < 0.0001) and serum uric acid (CKD group: 8.2 ± 2.2 mg/dl, Non-CKD group: 7.2 ± 1.7 mg/dl, p <0.05) are significantly different between CKD group and non-CKD group. Urinary UMOD excretion is also statistical significantly between two groups (CKD group: 3.7± 4.8, Non-CKD group: 5.8 ± 6.1, p <0.05). Using multivariate analysis, patients with CKD and gout were associated with lower urinary UMOD excretion than those who have gout alone [Odds Ratio 0.796, 95% confidence interval: 0.665-0.934, p=0.006). Patients with CKD and gout were also more likely to be older (p < 0.001) and have higher uric acid levels (p < 0.05). In non-gout patient, urinary UMOD excretion was not associated with status of CKD instead. CONCLUSIONS: Our study indicates that UMOD might play a role in the relationship between gout and CKD. Further studies with animal model of gout and CKD are mandatory to establish fundamental pathomechanism and explore the clinical implications.
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Chen, Man-Ling, and 陳曼伶. "Association of gout and gene polymorphism." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/27424735477406204309.
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碩士國立中興大學
生命科學院碩士在職專班
91
Gout is not a single disease but a term used to describe a group of metabolic disorders characterized by tissue deposition monosodium urate (MSU) monohydrate crystals from hyperuricaemic body fluids. Major clinical manifestations include gouty arthritis, tophus, gouty nephropathy, and uric acid calaulus in the urinary tract. According to epidemiological and experimental studies, the incidence of gout is higher in men than in women. In addition to life style and eating habits, genetic factors are probably the major cause of the disease, although the exact mechanism remains to be determined. The purpose of this study was to examine whether single nucleutide polymorphisms (SNPs) of the IL-1（IL-1β promoter, IL-1βexon5, IL-1 Ra）, IL-4 and tumor necrosis factor alpha （TNFα-308）gene polymorphisms, the CAG repeats in the AR gene and the TA repeats in the ER gene were associated with gout. This study included 196 gout patients and health individuals as control subjects. Amplification of the gene markers was carried out by polymerase chain reaction (PCR). The amplified products were analyzed by restriction fragment length polymorphism (RFLP) and sequence analysis. We used SPSS10.0 to perform statistical analysis upon the data collected. No significant differents were observed in the genetic distribution, allelic frequencies or allele carriage rates of the IL-1（IL-1β promoter, IL-1βexon5, IL-1 Ra）, IL-4 and TNFα-308 gene between patients with gout and health control subjects. Additionally, we did not detect any association between IL-1(IL-1β promoter, IL-1βexon5, IL-1 Ra), IL-4 and TNFα-308 genotypes and the clinical and laboratory profiles in gout patients, except for hypertriglyceridemia. There were significant differences in the IL-1βexon 5 genotype and TNFα-308 polymorphisms between gout patients with and without hypertriglyceridemia. It was found that IL-1βexon 5 E2 gene polymorphism can trigger gout in patient with hypertriglyceridemia. It was also noted that the TNFαA gene polymorphism can trigger gout in patient with hypertriglyceridemia. While both IL-1βexon 5 E2 and TNFαA seen to cause gout, both IL-1βexon 5 E1 gene and TNFαG genes are protective factors. Associations between gout and the CAG repeats in the AR gene and the TA repeats in the ER gene were evaluated. There were no statistical differens between gout patients and the normal controls in the distribution of CAG repeats in the AR gene. But, there was a significant difference between gout patients and the normal controls in the distribution of TA repeats in the ER gene. The risk of gout in patients with 10-15 TA dinucleotide repeats is 1.75-fold and 29-fold of that in patients with 16-21 TA dinucleotide repeats and 22-27 TA dinucleotide repeats, respectively. In other words, the fewer number of TA dinucleotide repeats, the higher the rate of coming down with gout. The results of our study suggest that the IL-1βexon 5、TNFα-308 and estrogen receptor gene polymorphisms are associated with gout, and they may be candidate genetic markers for risk of gout.
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許芳瑾. "An Analysis of Gout Patients’Health Services Utilization." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/26077113512699015261.
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Chen, Ying-Chou, and 陳英州. "Proteomic Analysis of Down’s Syndrome Patients with Gout." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/06064933077946826566.
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碩士長庚大學
臨床醫學研究所
94
Background: In this study, the expression of hypoxanthine-guanine phosphoribosyl transferase (HPRT) in Down’s syndrome patients with gout (DS/G) was determined, and the possible underlying mechanisms were characterized with proteomic tools. Methods: Blood samples from DS/G patients, control and gout patients (without DS), were recruited from the rheumatology outpatient clinic. Baseline enzyme assays were recorded and RT-PCR used to identify the expression of the HPRT gene. 2-D electrophoresis and mass spectrometry were utilized to determine a plausible explanation concerning the pathogenetic mechanisms leading to the increase in uric acid levels in DS patients. Results: Two DS patients were diagnosed with gouty arthritis. Their HPRT enzyme activity was found to be slightly lower than that of the normal control. The level of HPRT expression was also slightly decreased in DS/G patients compared with the control. Serum protein profiles of these two DS/G patients revealed that haptoglobinαchain and apolipoprotein A1 (ApoA1) were both significantly downregulated. Protein expression was validated by immunoblot. Conclusion: Our results revealed that their low level of haptoglobin, related to renal dysfunction, may have affected uric acid excretion and led to gout. However, decreased ApoA1 revealed a positive correlation between defective lipid metabolism and gouty arthritis in DS/G patients.
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Chang, Shun Jen, and 章順仁. "The Epidemiological Study of Gout in Taiwan Aborigines." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/95763692592067516278.
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博士高雄醫學院
醫學研究所
86
The epidemiological study of gout in Taiwan Aborigines(1998) The Graduate Institute of MedicineThe Graduate student : Shun-Jen Chang, Adviser: Ying-Chin KoStudent No: 8381005Abstract There are three aboriginal tribes (Bunun, Paiwan and Atayal) and twonon-aborigines (Fukien-Taiwanese and Hakka ) were included as study''spopulation. This study was divided into three parts, the first subject wasto explore the hyperuricemic prevalence and related factors from the abovefive populations whose age were between five and 14 years. The secondsubject focused the adult''s gout and hyperuricemic prevalence and therelated factors. We visited the persons whose age great than 40 years bydoor to door, the gout disease was self-reported from the subject and hadbeen identified by a practical doctor. The third was to reveal the HPRT genefrom a severe gout patient who was with gout pedigree, after finding themutation from the patient, then by using PCR-RFLP method to screen hisfamilies and three tribes'' children. The results showed that (1) there were 1214 children had been includedin this study from the five tribes between Jul 1993 and Mar 1994; Overall,the hyperuricemic ( uric acid ≧ 7.5 mg/dl) prevalence was 27.3% (332/1214),the hyperuricemic rate among male was 30.4%, and 24.2% among female andthere was statistical difference among sex (186/611, 146/ 603; p<0.05). TheAtayal tribe, no matter male or female, had the highest prevalence ofhyperuricemia, the Paiwan tribe followed, and the non-Aboriginal tribes thelowest. After the preliminary and logistic regression model adjusted theconfounders, the result showed that the factors related to hyperuricemia hadage, sex, body mass index, tribes, the serum triglycerides and cholesterolconcentration. Without the interference of the living habits in adults such as tobaccosmoking, alcohol consumption and betel nut chewing, the factor of Aborigineshad major effect on serum uric acid was concluded. (2) The prevalence of gout disease among aboriginal male and female were9.3% (26/281) and 3.0% (11/371), which were significant higher than thenon-aborigines (0.4% in both male and female). The related factors of goutdisease were explored by logistic regression model, and found that theaboriginal men with hyperuricemia tended to get the gout disease. About thefactors related to hyperuricemia showed that the aborigines withtriglycerides over 170 mg/dl and the ratio of waist line over hip linegreater than 0.9 were likely to have hyperuricemia. The factor of tribe havethe major effect on the onset of gout disease was included. (3) One new mutation locate at the HPRT cDNA 152 nucleotide was foundfrom a severe gout patient (proband) whose mother originated from Tsou tribe, thus the mutation was named as HPRTTsou according to his mother''s tribe. The mutation cause the nucleotide transition from G to A which cause the 51amino acid transgression from argentine to glutamate. After that, wescreened the proband''s families, the children from Tsou''s tribes, Atayaltribe and Bunun tribe by using the PCR-RFLP method. The results showed that85.7% (6/7) of the proband''s siblings had HPRTTsou from their mother, andalso there were 50% (4/8) of the children of proband''s siblings inheritedthis mutation from their carried mother. Among the children, only twofemales had this mutation which one from Atayal tribe and one from Tsoutribe. In conclusion, no matter the hyperuricemia or gout disease, theAborigines have the higher prevalence than non-aborigines, thus the tribefactor may be considered as a most important factor. In another hand, theHPRTTsou distribute low prevalence among Atayal tribe and Tsou tribe (1.4%;1/70, 4.5%; 1/22, respectively). This study showed that both of the aboriginal children and adults havehigh prevalence of hyperuricemia, and the gout disease also predominated inthe Aborigines. Furthermore, there was a HPRT point mutation would cause theuric acid accumulated existed in the Tsou tribe''s offspring. Thus, afterexcluded the confounding factors in environment, we believe the Aboriginesmay have another gene mutation will cause the gout disease onset.