Relevant bibliographies by topics / Glycotransferase

Academic literature on the topic 'Glycotransferase'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Glycotransferase"

1

Borges, Chad R., Douglas S. Rehder, and Paolo Boffetta. "Multiplexed Surrogate Analysis of Glycotransferase Activity in Whole Biospecimens." Analytical Chemistry 85, no. 5 (February 15, 2013): 2927–36. http://dx.doi.org/10.1021/ac3035579.

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2

Zhu, Zhongyu, Boopathy Ramakrishnan, Jinyu Li, Yanping Wang, Yang Feng, Ponraj Prabakaran, Simona Colantonio, Marzena A. Dyba, Pradman K. Qasba, and Dimiter S. Dimitrov. "Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar." mAbs 6, no. 5 (September 3, 2014): 1190–200. http://dx.doi.org/10.4161/mabs.29889.

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3

Rahman, A. K. M. Shofiqur, Naoyasu Sugitani, Masahiro Hatsu, and Kazuhiro Takamizawa. "A role of xylanase, α-L-arabinofuranosidase, and xylosidase in xylan degradation." Canadian Journal of Microbiology 49, no. 1 (January 1, 2003): 58–64. http://dx.doi.org/10.1139/w02-114.

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Renewable natural resources such as xylans are abundant in many agricultural wastes. Penicillium sp. AHT-1 is a strong producer of xylanolytic enzymes. The sequential activities of its xylanase, α-L-arabinofuranosidase, and β-xylosidase on model hemicellulose oat–spelt xylan was investigated. Optimum production of the enzymes was found in culture containing oat–spelt xylan at 30°C and initial pH 7.0 after 6 days. The enzymes were partially purified by ammonium sulphate fractionation and anion-exchange chromatography on DEAE-Toyopearl 650 S. The apparent molecular mass was 21 kDa, and the protein displayed an "endo" mode of action. The xylanase exhibited glycotransferase activity. It synthesized higher oligosaccharides from the initial substrates, and xylotriose was the shortest unit of substrate transglycosylated. Xylanolytic enzymes (enzyme mixture) produced by this Penicillium sp. interacted cooperatively and sequentially in the hydrolysis of oat–spelt xylan in the following order: α-L-arabinofuranosidase [Formula: see text] xylanase [Formula: see text] β-xylosidase. All three enzymes exhibited optimal activity under the same conditions (temperature, pH, cultivation), indicating that they alone are sufficient to completely depolymerize the test xylan. Results indicate that the xylanolytic enzyme mixture of Penicillium sp. AHT-1 could be useful for bioconversion of xylan-rich plant wastes to value-added products.Key words: xylanase, enzyme purification, enzymatic hydrolysis, Penicillium sp. AHT-1.
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Alonso, Leocadio, Patrick Fox, María Calvo, and Javier Fontecha. "Effect of Beta Cyclodextrin on the Reduction of Cholesterol in Ewe’s Milk Manchego Cheese." Molecules 23, no. 7 (July 20, 2018): 1789. http://dx.doi.org/10.3390/molecules23071789.

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Beta-cyclodextrin (β-CD) is a cyclic oligosaccharide consisting of seven glucose units and is produced from starch using cyclodextrin glycotransferase enzymes to break the polysaccharide chain and forming a cyclic polysaccharide molecule. The use of β-CD in food research for reduction of cholesterol is increasing due to its affinity for non-polar molecules such as cholesterol. The aim of this study was to evaluate the feasibility of using β-CD in cholesterol removal from pasteurized ewe’s milk Manchego cheese and evaluate the effect on the main components of the milk, lipids, and flavor characteristics. Approximately 97.6% cholesterol reduction was observed in the cheese that was treated using β-CD. Physicochemical properties (fat, moisture and protein) were not changed by the β-CD treatment, except the soluble nitrogen and non-protein nitrogen that showed slight differences after the treatment. The amount of the different components of the lipid fraction (fatty acids, triglycerides and phospholipids) were similar in cheeses treated and not treated with β-CD. Flavor compound and short chain free fatty acids were not mostly significantly influenced by the effect of the β-CD. β-CD molecules are edible and nontoxic and as a result they can be used safely for cholesterol removal processing in cheese manufacturing. Therefore, the present study suggests that β-CD treatment is an effective process for cholesterol removal from Manchego cheese while preserving its properties.
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Glickman, J. Fraser, and Doug Auld. "Generic Glycotransferases Assays." Assay and Drug Development Technologies 2, no. 4 (August 1, 2004): 445. http://dx.doi.org/10.1089/1540658041850706.

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6

ZHU, Jing, Itaru WATANABE, Amanda POHOLEK, Matthew KOSS, Barbara GOMEZ, Chaowen YAN, Esperanza RECIO-PINTO, and William B. THORNHILL. "Allowed N-glycosylation sites on the Kv1.2 potassium channel S1–S2 linker: implications for linker secondary structure and the glycosylation effect on channel function." Biochemical Journal 375, no. 3 (November 1, 2003): 769–75. http://dx.doi.org/10.1042/bj20030517.

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N-glycosylation is a post-translational modification that plays a role in the trafficking and/or function of some membrane proteins. We have shown previously that N-glycosylation affected the function of some Kv1 voltage-gated potassium (K+) channels [Watanabe, Wang, Sutachan, Zhu, Recio-Pinto and Thornhill (2003) J. Physiol. (Cambridge, U.K.) 550, 51–66]. Kv1 channel S1–S2 linkers vary in length but their N-glycosylation sites are at similar relative positions from the S1 or S2 membrane domains. In the present study, by a scanning mutagenesis approach, we determined the allowed N-glycosylation sites on the Kv1.2 S1–S2 linker, which has 39 amino acids, by engineering N-glycosylation sites and assaying for glycosylation, using their sensitivity to glycosidases. The middle section of the linker (54% of linker) was glycosylated at every position, whereas both end sections (46% of linker) near the S1 or S2 membrane domains were not. These findings suggested that the middle section of the S1–S2 linker was accessible to the endoplasmic reticulum glycotransferase at every position and was in the extracellular aqueous phase, and presumably in a flexible conformation. We speculate that the S1–S2 linker is mostly a coiled-loop structure and that the strict relative position of native glycosylation sites on these linkers may be involved in the mechanism underlying the functional effects of glycosylation on some Kv1 K+ channels. The S3–S4 linker, with 16 amino acids and no N-glycosylation site, was not glycosylated when an N-glycosylation site was added. However, an extended linker, with an added N-linked site, was glycosylated, which suggested that the native linker was not glycosylated due to its short length. Thus other ion channels or membrane proteins may also have a high glycosylation potential on a linker but yet have similarly positioned native N-glycosylation sites among isoforms. This may imply that the native position of the N-glycosylation site may be important if the carbohydrate tree plays a role in the folding, stability, trafficking and/or function of the protein.
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Pejenaute-Ochoa, María Dolores, Carlos Santana-Molina, Damien P. Devos, José Ignacio Ibeas, and Alfonso Fernández-Álvarez. "Structural, Evolutionary, and Functional Analysis of the Protein O-Mannosyltransferase Family in Pathogenic Fungi." Journal of Fungi 7, no. 5 (April 23, 2021): 328. http://dx.doi.org/10.3390/jof7050328.

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Protein O-mannosyltransferases (Pmts) comprise a group of proteins that add mannoses to substrate proteins at the endoplasmic reticulum. This post-translational modification is important for the faithful transfer of nascent glycoproteins throughout the secretory pathway. Most fungi genomes encode three O-mannosyltransferases, usually named Pmt1, Pmt2, and Pmt4. In pathogenic fungi, Pmts, especially Pmt4, are key factors for virulence. Although the importance of Pmts for fungal pathogenesis is well established in a wide range of pathogens, questions remain regarding certain features of Pmts. For example, why does the single deletion of each pmt gene have an asymmetrical impact on host colonization? Here, we analyse the origin of Pmts in fungi and review the most important phenotypes associated with Pmt mutants in pathogenic fungi. Hence, we highlight the enormous relevance of these glycotransferases for fungal pathogenic development.
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8

Dejgaard, Selma Yilmaz, Ayesha Murshid, Kristina M. Dee, and John F. Presley. "Confocal Microscopy-based Linescan Methodologies for Intra-Golgi Localization of Proteins." Journal of Histochemistry & Cytochemistry 55, no. 7 (March 19, 2007): 709–19. http://dx.doi.org/10.1369/jhc.6a7090.2007.

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Localization of resident Golgi proteins to earlier ( cis) or later ( trans) Golgi compartments has traditionally required quantitative immunocytochemistry and electron microscopy, which are inaccessible to many researchers. For this reason, light microscopy has often been used, initially for localization of Golgi glycotransferases and, more recently, for other Golgi proteins (e.g., Arf1, GBF1, Rab6). Quantitation of light microscopic intra-Golgi localization can be problematic. We describe here a novel quantitative light microscopic methodology using linescans crossing the Golgi ribbon. Our method determines a localization for the unknown protein in a one-dimensional coordinate system in which 0.0 corresponds to localization of a cis marker and 1.0 to localization of a trans marker. We also describe a variant of this methodology in which Golgi morphology is simplified by nocodazole-induced dispersal into ministacks, allowing a fully automated analysis. In our assay, β1,4-galactosyltransferase-YFP and Golgin97 localize similarly to trans markers, whereas p115, GBF1, and p58-YFP are similarly near other cis markers. The medial Golgi protein α1,3–1,6-mannosidase II gives an intermediate localization in this assay. These methodologies may prove useful in instances where electron microscopy is technically difficult as well as when rapid analysis of large numbers of samples is required.
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9

Urun, Yuksel, Kathryn M. Wilson, Irene M. Shui, Edward L. Giovannucci, Brian M. Wolpin, Paul Linh Nguyen, Lorelei A. Mucci, and Toni K. Choueiri. "ABO blood group and risk of lethal prostate cancer." Journal of Clinical Oncology 32, no. 4_suppl (February 1, 2014): 69. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.69.

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69 Background: An individual’s blood group is defined by variability in glycotransferases expressed on red blood cell surface; these ABO antigens are also highly expressed on epithelial cells. Previous studies have suggested associations between ABO blood group and increased risk of epithelial cancers including gastric, pancreatic, and ovarian; however, its relationship with risk of prostate carcinoma, and its aggressiveness remains unclear. Methods: We prospectively evaluated the association between ABO blood group and risk of lethal prostate cancer in the Health Professionals Follow-up Study (HPFS) from 1996 to 2008. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models with adjustment for other risk factors and prostate-specific antigen testing. Results: During 12 years of follow-up of 26,602 men, 2,703 cases of incident prostate cancer were documented, including 289 lethal cases (prostate cancer death or distant metastases). The frequency of ABO blood type was similar between men who developed prostate cancer (37% A, 7% AB, 13% B, and 43% O) and other participants (37% A, 8% AB, 12% B, and 43% O). On multivariate analysis, blood type was not associated with overall prostate cancer incidence. However, compared to men with blood group O, those with blood group AB were significantly less likely to develop lethal prostate cancer (multivariate-adjusted HR = 0.39 [95% confidence interval {CI} = 0.18-0.85]). There was no association between type B or A compared to O with lethal disease. ABO blood type was not significantly associated with the risk of advanced stage or high-grade cancers (Gleason score 8 to 10). Conclusions: Blood group AB was associated with a lower risk of lethal prostate cancer compared to blood group O. Further studies are needed to replicate these findings and to clarify possible biological mechanisms underlying this association.
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Tatlow, Dean. "Miglustat: A glycotransferase inhibitor for Covid-19 treatment." Qeios, January 21, 2021. http://dx.doi.org/10.32388/pe4tsq.

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Dissertations / Theses on the topic "Glycotransferase"

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Azazna, Djamille. "Les bambusurils : molécules-cages pour l'encapsulation d'anions et utilisation comme nouvelles plateformes multivalentes d'intérêt biologique." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS454.

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Les bambusurils, BU[4] et BU[6], sont des oligomères cycliques apparentés aux cucurbiturils, CBs, constitués respectivement de 4 et 6 motifs glycolurils. Les bambusurils diffèrent des CBs par la présence de glycolurils difonctionnalisés.Les BU[6] ont la capacité d'encapsuler des anions dans leur cavité, propriété intéressante pour la décontamination d'effluents, par exemple.Une nouvelle famille de bambusurils, les allylbambusurils, qui possèdent des groupements allyles sur leur portail macrocyclique, a été développée. Leur post-fonctionnalisation par oxydation, métathèse croisée ou réaction thiol-ène a été étudiée. Par réaction thiol-ène, des BU[4] et BU[6], fonctionnalisés respectivement par 8 ou 12 thiols d'intérèt, ont été obtenus. Les BU[6] sont toujours isolés avec un halogènure à l’intérieur de leur cavité. Une méthode utilisant l’hexafluoroantimonate d’argent a été mise au point pour les décomplexer. L'affinité de ces nouveaux BU[6] exempts d'anion, pour différents halogénures, a été évaluée par RMN 1H.Des glycobambusurils ont été synthétisés par réaction thiol-ène en présence de sucres fonctionnalisés par des thiols. Ces glycoBUs donnent accès à des plateformes multivalentes de valence 8 pour les BU[4] et 12 pour les BU[6]. Le pouvoir inhibiteur de ces nouvelles plateformes a été testé sur l'enzyme WaaC, une heptosyltransferase présente dans la paroi bactérienne. Les tests enzymatiques montrent que ces glycobambusurils sont des plateformes multivalentes prometteuses
Bambusurils, BU[4] and BU[6] are cyclic oligomers that belong to the cucurbiturils family, CBs, assembled respectively by 4 and 6 glycoluril units. Bambusurils are different from cucurbiturils because of their difunctionalized glycolurils. BU[6] are able to encapsulate anions inside their cavity and this property can be useful for the treatment of effluents.A new family of BUs, the allylbambusurils having allyls groups on their macrocyclic portal, has been developed. Their postfunctionalization by oxidation, cross metathesis and thiol-ene coupling has been studied. BU[4] and BU[6] functionalized by respectively 8 and 12 thiols of interest have been prepared.BU[6] are always obtained with an halide inside the cavity. A method using silver hexafluoroantimonate has been developed to remove this halide. Binding constants of these new empty bambusurils have been determined towards severals halide by 1H NMR.Glycobambusurils have been synthesized by thiol- ene coupling with thiosugars. These glycoBUs can lead to multivalent platforms of valency up to 8 for BU[4] and 12 for BU[6]. Inhibition activity of these new platforms has been tested on WaaC enzyme, an heptosyltransferase found in bacterial cell wall. Enzymatic tests show that these glycobambusurils are promising multivalent platforms
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Pham, Trang Anh. "Cell wall biosynthesis in barley powdery mildew Blumeria graminis f. sp. hordei." Thesis, 2019. http://hdl.handle.net/2440/120552.

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Blumeria graminis f. sp. hordei (Bgh) is the causal agent of powdery mildew in Hordeum vulgare (barley). Bgh is an obligate biotrophic pathogen, meaning that it relies on the host for survival. The Bgh asexual life cycle initiates when airborne conidia land on the host surface and germinate. An appressorium develops and penetrates the host to form an intracellular feeding structure called a haustorium. Following successful host entry, epiphytic mycelia spread along the surface and conidiophores emerge to produce vast quantities of conidia. As the fungal cell wall is essential for survival it is an obvious target for the design of novel antifungal agents for disease control. Depending on the pathogen species, the composition of the cell wall can vary significantly. In order to advance disease control practices, it is imperative to understand the composition of the cell wall and the genes involved in cell wall metabolism. This work focuses on characterising the Bgh fungal cell wall and examining the genes responsible for its synthesis during pre-penetrative events of pathogenesis. In addition, in vitro assays have been performed to investigate the biochemical activity for a number of key biosynthetic enzymes. Permethylation glycosidic linkage analysis of the Bgh conidia cell wall has revealed their cell wall composition for the first time. The conidial cell wall of Bgh is predominantly made of glucose and has a greater proportion of galactose residues compared to other well characterised fungal cell walls. Trace amounts of xylose residues were also observed. Analysis of the Carbohydrate Active enZymes (CAZy) present within the Bgh genome was conducted to identify genes involved in cell wall metabolism, as previous CAZy annotations of the genome were incomplete. A greater number of CAZy genes were identified compared to previous studies. Many of the biochemical activities of CAZy enzymes involved in cell wall synthesis are still unknown due to the technically challenging work required. In an attempt to understand cell wall synthesis in Bgh, several genes involved in chitin and b-1,3- glucan synthesiswere heterologously expressed with the aim to confirm biochemical activity and perform in vitro enzyme kinetic assays. Following successful expression of four chitin synthases, only the class I chitin synthase was able to be expressed and purified in an active state. To examine pre-penetrative events in Bgh without any contamination from the host plant it was essential to establish an in vitro system for germination of the Bgh conidia. A previously established in vitro assay using n-hexacosanal was adapted to generate in vitro fungal material for analysis. n-Hexacosanal is a known inducer of Bgh germination and appressorial development. Profiling of the transcriptome and proteome during the appressorial germ tube stage revealed that there was a notable shift towards energy and protein production during appressorial development. Linkage analysis of the appressorial cell wall showed a significant decrease in the galactose portion of the cell wall during the appressorial stage and the appearance of novel branched xylose linkages that have not been observed in fungal pathogens previously. The use of this cultivation method demonstrates that it is possible to analyse the pre-penetrative processes of Bgh development in vitro.
Thesis (Ph.D.) -- University of Adelaide, School of Agriculture, Food & Wine, 2019
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Book chapters on the topic "Glycotransferase"

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Schomburg, Dietmar, and Dörte Stephan. "Dolichyl-diphosphooligosaccharide-protein glycotransferase." In Enzyme Handbook 12, 571–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_119.

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Conference papers on the topic "Glycotransferase"

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Zhu, Zhongyu, Ramakrishnan Boopathy, Jinyu Li, Ponraj Prabakaran, Simona Colantonio, Yang Feng, Yanping Wang, Marzena A. Dyba, and Dimiter S. Dimitrov. "Abstract 2486: Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2486.

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Reilly, John P., Nuala J. Meyer, Rui Feng, Scarlett Bellamy, Paul N. Lanken, Robert Gallop, Michael G. S. Shashaty, et al. "Blood Group A And ABO Glycotransferase Genotype Are Associated With Increased Risk Of Acute Lung Injury After Blunt Trauma." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1153.

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