Dissertations / Theses on the topic 'Glycosylation'
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Seward, Christopher M. P. "Stereoselective glycosylation chemistry." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270281.
Full textRising, Thomas W. D. F. "Glycosylation using endohexosaminidases." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436989.
Full textYassine, Hanane. "Caractérisation d’endocan murin : dualité fonctionnelle pro- ou anti-tumorale de l’endocan selon son statut de glycosylation. Etude des mécanismes d’action anti-tumorale." Thesis, Lille 2, 2014. http://www.theses.fr/2014LIL2S029/document.
Full textSolid tumor requires a supply of oxygen and nutrients for growth but also for metastasizing to another organ. Tumor angiogenesis is the phenomenon exploited by tumor to fulfill these needs. The"Tip cells" located at the end of sprouting capillaries initiate and guide the growth of neovessels. These cells are currently considered as an important therapeutic target for anti-angiogenic drugs. Many studies have identified a cluster of molecular markers selectively expressed by the \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\"Tip cells.\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\" One of these markers called “endocan”, has represented the subject of the thesis work.Endocan is a circulating proteoglycan overexpressed in many human carcinomas, and expression is often associated with poor prognosis. It is suspected to play an important role in tumor development. Through its glycan chain, endocan modulates the effect of growth factors, and also the migration of endothelial cells. My thesis work has focused on the biochemical and functional characterization of mouse endocan in order to obtain a useful animal model for better understanding of the pro tumoral activity of human endocan. The work presented in this manuscript shows that mouse endocan is a chondroitin sulfate proteoglycan but much less glycanated than human endocan. Our data indicate that combinatorial distant domains from the O-glycanation site, located within exons 1 and 2 determine the glycanation pattern of endocan. In SCID mouse model of tumor xenograft we demonstrated that mouse endocan does not exhibit a pro tumoral activity. In opposite to the human homologue, overexpression of mouse endocan in HT-29 cells delayed the tumor appearance and reduced the tumor growth rate. This tumor growth inhibition was mostly supported by non glycanated mouse endocan. Unexpectedly, human non glycanated endocan overexpressed in HT-29, A549, or K1000 cells also delayed the tumor appearance and reduced the tumor growth. Moreover, systemic delivery of human non glycanated endocan also reproduced HT-29 tumor delay. In vitro, endocan polypeptide did not affect HT-29 cell proliferation, nor cell viability.Interestingly, a stromal inflammatory reaction was observed only in tumors overexpressing endocan polypeptide. In addition, depletion of CD122+ cells was able to delete partially the tumor delaying effect of endocan polypeptide. These results reveal a novel pathway for endocan in the control of tumor growth, which involves innate immune cells
Rivinoja, A. (Antti). "Golgi pH and glycosylation." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292699.
Full textAnttonen, Katri Pauliina. "Protein glycosylation in actinomycetes." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92515.
Full textGreen, L. "Studies in glycosylation methodology." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599657.
Full textKarg, Saskia Ruth. "N-glycosylation engineering in tobacco /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17989.
Full textKameh, Homa. "Aberrant glycosylation in HEMPAS patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28786.pdf.
Full textHarthill, Jean Elizabeth. "N-glycosylation of horseradish peroxidase." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292612.
Full textKaloo, Sara. "Glycosylation of Carbohydrates by Glycosyltranferases." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508556.
Full textAllen, Alice. "IgA glycosylation in IgA nephropathy." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35028.
Full textKeenan, Tessa. "Protein O-glycosylation in Streptomyces." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/16889/.
Full textCox, Daniel. "New approaches to stereocontrolled glycosylation." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b3eb90c9-3149-4761-930f-391607ee134c.
Full textSingh, Govind Pratap. "New approaches to stereocontrolled glycosylation." Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/11126.
Full textLige, Bao. "Role of glycosylation in peanut peroxidase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0006/NQ42539.pdf.
Full textLeaney, Sarah J. "GIT : glycosylation 'via' inter/intramolecular transfer." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409812.
Full textWarren, C. E. "N-glycosylation in mice and rats." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315795.
Full textMcAulay, Kathrine. "Glycosylation of Staphylococcus aureus surface proteins." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555122.
Full textDay-Williams, Michaela Joanne. "Polar flagellum glycosylation in aeromonas caviae." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515262.
Full textHong, Sung You. "Surface glycosylation and filling of nanotubes." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509960.
Full textKong, Leopold. "HIV-1 gp120 : flexibility and glycosylation." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533859.
Full textHills, Anna E. "Control of monoclonal antibody N-glycosylation." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344101.
Full textHuffman, Jennifer Elizabeth. "Genetic analysis of protein N-glycosylation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10038.
Full textGorbea, Carlos M. "Expression and glycosylation of meprin isoforms." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-07282008-134351/.
Full textTaylor, Thomas Alex. "Investigations into novel enzymatic glycosylation methods." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:3bfd1078-79d8-4c68-83a0-0bb5343583eb.
Full textMas, Eric. "Glycosylation de la lipase sels biliaires dépendante du pancréas : Glycosylation de la lipase sels biliaires dépendante du pancréas." Aix-Marseille 2, 1995. http://www.theses.fr/1995AIX22028.
Full textZerbib, Marie. "Etude de la glycosylation de flavanols dans le raisin et incidence dans les vins." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTG051/document.
Full textFlavan-3-ols belong to a group of polyphenols present in a wide variety of plants, and particularly in grapeberries. They play an important role in defense mechanisms in plants, have a significant impact on wine organoleptic properties; and their beneficial effects on human health may help to protect against chronic diseases such as atherosclerosis. The sequence of common flavanol monomer biosynthesis is widely described in the literature, but the formation mechanisms of proanthocyanidins (PA) remain unknown. Studies show that flavanol glycosides are potential intermediates in PA polymerization and have transporter roles of monomeric units from cytoplasm to vacuole in cell, where polymerization takes place. Global screening of grapeberry flavanol glycosides were carried out at three stages of grape development and in wines of different varieties; skin and seeds were measured separately using an UPLC-DAD-ESI-MS method. The composition of the target isomers depends on different parameters such as tissue type or stage of development. The presence epi catechin monoglycoside is reported here for the first time in grapes. Using (+)-catechin 4’-O--glucoside and 7-O--glucoside hemisynthesis, several monomers were shown to -glucosides. Quantitative analysis demonstrates the evolution of flavanol glycosides in both skin and seeds during the development of three grapevine varieties. For the first time monomeric and dimeric (epi) catechin diglycosides were revealed and shown accumulate only in grape seeds during ripening. A reduction in the concentration of monomeric (epi) catechin monoglycoside was observed during grape skin development. Dimeric (epi) catechin monoglycosides accumulate after veraison and then decrease at the end of grape ripening. The extraction profiles of flavanol glycosides during red grape fermentation showed similar evolution patterns for both varieties used. The total concentration of different compound families increases during winemaking, and then decreases at the end of fermentation. Degradation of specific compounds was observed at the end of fermentation which may be explained by the activity of glycosidases from grape extracts released during fermentation and pressing
Luz, Johanna Da. "Aspects of N-glycosylation in human IgE /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-130-6.
Full textHo, Ming-Kai 1978. "Characterization of glycosylation of prolactin in galliformes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98724.
Full textCritchley, Alison. "Congenital disorders of glycosylation and disease pathogenesis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424758.
Full textAl-Ghouleh, Abeer. "The role of glycosylation in allergen recognition." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12103/.
Full textMcKenzie, Samuel Noel. "Asymmetric Control of the Diastereoselectivity of Glycosylation." Thesis, University of Canterbury. Chemistry, 2011. http://hdl.handle.net/10092/5931.
Full textMann, Alexander Charles. "Serum protein glycosylation in alcoholic liver disease." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323479.
Full textChen, Qiushi. "Mass spectrometric investigation of biomedically important glycosylation." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/56202.
Full textYuk, Inn Huam Yvonne. "Protein expression and glycosylation in CHO cells." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8201.
Full textIncludes bibliographical references (p. 193-207).
A successful mammalian cell culture process depends on sufficient expression and correct glycosylation of the recombinant product. Low product titer and inconsistent protein glycosylation constitute two major problems frequently encountered in biopharmaceutical production. Using Chinese Hamster Ovary (CHO) cells expressing recombinant human interferon-gamma (IFN-y) as the model system, this thesis investigated strategies that can potentially enhance heterologous protein expression or control the extent of protein glycosylation. There has been considerable interest in developing culture strategies to improve productivity in mammalian cell lines by limiting the cellular growth rate. An initial investigation demonstrated the difficulty in obtaining growth-arrested cells that are robust and productive. In the following study, a method to rapidly generate and isolate CHO cells that exhibit enhanced potential for use in proliferation-controlled bioprocesses was developed. By combining bicistronic retroviral technology with an appropriate selection strategy, a subpopulation was isolated from a heterogeneous cell population. To evaluate the effectiveness of this screening process, the performance of this selected subpopulation was compared with that of the original population under identical growth-arresting conditions. Important differences were observed: by contrast to the original population, the selected cells maintained consistently high viabilities and continued to stably express recombinant proteins after being growth-arrested for two weeks. Asparagine-linked (N-linked) glycosylation can significantly impact critical properties of human therapeutic proteins.
(cont.) An essential step in N-linked glycosylation is the transfer of an oligosaccharide from dolichol phosphate (Dol-P) to a potential glycosylation site on a polypeptide. Variability in the success of this reaction affects the extent of glycosylation on proteins. Radiolabeling studies showed that over the course of CHO batch culture, glycosylation precursor concentrations remained within a two-fold range, and overall protein glycosylation increased by 15-25%. Given the key role of Dol-P in glycosylation, its availability was postulated to limit glycosylation by controlling the abundance of glycosylation precursors. To test this hypothesis, the impact of Dol-P feeding on CHO cells was investigated. Although exogenous Dol-P was incorporated by CHO cells and processed into glycosylation precursors in a dose-dependent manner, Dol-P supplementation had no marked effects on the level of glycosylation precursors or on the extent of glycosylation.
by Inn Huam Yvonne Yuk.
Ph.D.
Mérit, Xavier. "Protéines G et glycosylation chez Aspergillus niger." Lyon 1, 1991. http://www.theses.fr/1991LYO10086.
Full textFernandes, Elisabete Cristina Nunes. "Humoral responses against esophageal cancer-associated glycosylation." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/11301.
Full textO cancro de esófago (CE) tem um mau prognóstico e uma baixa taxa de sobrevivência. É diagnosticado tardiamente, por endoscopia, um método invasivo que carece de especificidade e sensibilidade. Atualmente, não existem biomarcadores para melhorar a precisão do diagnóstico. A transformação maligna é acompanhada por alterações no padrão de glicosilação das células, que são utilizadas no diagnóstico não-invasivo, monitorização da doença, bem como terapêutica. Além disso, as proteínas exibindo glicosilação alterada são capazes de induzir respostas humorais. Os auto-anticorpos são uma nova geração de biomarcadores tumorais, com capacidade de amplificar alterações moleculares nos tumores. São ainda mais resistentes a proteólise o que os correspondentes epitopos. No entanto, pouco se sabe sobre a glicosilação em CE e a sua imunogenicidade. Assim, a primeira parte deste trabalho teve como objetivo identificar padrões de glicosilação no soro de doentes com CE por slot blotting. Foram considerados para este estudo os cinco antigénios tumorais Tn, sTn, T, sLea, e sLex. Verificou-se que os níveis de Tn, sTn, e do sLea estavam aumentados no soro de pacientes com EC, em comparação com um grupo de controlo, comparável em idade e género, sem doença maligna conhecida. A combinação dos antígenos Tn e sTn permitiu uma melhor discriminação entre CE e os controlos (sensibilidade de 93,8% e especificidade de 100%). A expressão destes antigénios nos tecidos de CE correspondentes, estimada por imuno-histoquímica, mostrou uma falta de correlação com as observações feitas no soro. Os dados sugerem que os padrões de glicosilação do soro são maioritariamente influenciados por proteínas não directamente secretadas ou libertadas por células tumorais, apesar de a sua contribuição não poder ser excluída. A segunda parte do trabalho visou identificar respostas humorais contra proteínas que transportam o sLea, um biomarcador associado à glicosilação com maior potencial de migração celular e metástase. A análise do perfil de IgG das amostras apresentou uma expressão aumentada de uma subclasse (IgG1) nos doentes com CE. As IgG1 produzidas de novo por indução tumoral demonstraram possuir sLea na sua estrutura, contribuindo assim para o aumento dos níveis deste antigénio no soro de doentes com EC. Ainda que os mecanismos biológicos por detrás deste evento não sejam ainda conhecidos, isso poderá permitir melhorar a sensibilidade e especificidade do teste sorológico de sLea (teste de CA19-9). Usando uma combinação de técnicas de immunoprecipiações e de Western blotting, foi ainda demonstrado, pela primeira vez, que as proteínas tumorais que transportam sLea podem induzir a produção de IgG1. A remoção do ácido siálico confirmou que a expressão de sLea era determinante para o reconhecimento de IgG1. Estas observações, bem como a identificação futura de proteínas imunogénicas transportadoras de sLea, prmitirão determinar o seu valor clínico e poderão ser um ponto de partida para o desenvolvimento de testes serológicos baseados em autoanticorpos. Em suma, eviências importantes foram encontradas com este estudo, que permitirão o desenvolvimento de testes serológicos não invasivos para a detecção de CE
Esophageal cancer (EC) has an extremely poor prognosis and decreased overall survival. It is generally diagnosed at a late stage, by endoscopy, which is invasive and lacks both specificity and sensitivity. At the moment, there are no biomarkers to improve the accuracy of diagnosis. The modification of cell glycosylation patterns is a recognized hallmark of cancer, explored in non-invasive diagnostic, therapeutic decision, disease monitoring as well as therapeutics. Moreover, abnormally glycosylated proteins have been proven capable of eliciting humoral responses. Autoantibodies are regarded as the new generation of tumor biomarkers, cable to amplifying events occurring in tumors and showing higher stability to proteolysis. Nevertheless, little is known about EC associated glycosylation nor and its immunogenicity. Based on these considerations, the first part of this work aimed to identify glycosylation patterns in serum associated with EC. Tn, sTn, T, sale, and sLex, the most studied tumors-associated carbohydrate antigens, were screened by slot blotting. The levels of Tn, sTn, and sLea antigens were found significantly increased in the serum of EC patients, when compared to a control group of matched age and gender, without known malignancy. Moreover, the combination of the Tn and sTn antigens allowed the best discrimination between EC and controls (93.8% sensitivity and 100% specificity). Still, the expression of these antigens in the corresponding EC tissues, estimated by immunohistochemistry, showed a lack of correlation with the observations made in serum. Data suggests that glycosylation patterns of serum are mostly influenced by proteins that are not directly secreted or released from tumor cells, even though their contribution cannot be excluded. The second part of the work aimed to identify humoral responses against proteins carrying the sLea, a glycosylated biomarker associated with increased potential of cellular migration and metastasis. The analysis of the IgG profile of the samples showed increased expression of IgG subclasse 1 (IgG1) in EC patients. De novo produced IgG1 were found to carry sLea, accounting for the increase in the levels of this glycan in the serum of EC patients. Even though the biological events underlying these observations remain to be clarified, this may allow improving the sensibility and specificity of the serological test for sLea (CA19-9 test). Using a combination of immunoprecipiations and western blotting techniques it was further demonstrated, for the first time, that tumor proteins carrying sLea could elicit IgG1 production. Furthermore, experiments using desialylated proteins confirmed that the expression of sLea expression was determinant for IgG1 recognition. These observations and the future identification of the immunogenic proteins carrying sLea will allow determining the clinical value of this explorative work and guiding the development of autoantibody-based serological tests. Altogether, important insights have been provided to guide the development of non-invasive serological tests for the detection of EC.
Borentain, Patrick. "Voies de la glycosylation et carcinome hépatocellulaire." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5047.
Full textGlycosylation is an enzymatic process that consists of the addition of glycosyl groups to compounds (sugars, lipids or proteins), thus modifying their properties. Glycosylation is involved in the detoxification of xenobiotics and variations in activity of enzymes responsible have been identified as a potential risk factor for cancer in particular in organs in contact with the external environment. In the first part of our work we study the impact of polymorphisms of detoxification enzyme (UGT1A7, GST and XRCC1) on the risk of hepatocellular carcinoma. We show that the combination of genetic polymorphisms of such enzymes may increase the risk of HCC. Modifications in the expression of surface glycoproteins have been observed in cancer cells and play a role in their interactions with the tumoral microenvironment. In the second part, we study the effect of inhibition of interactions of HCC cells / endothelial cells on tumor growth by blocking the interaction between sialyl Lewis x and E-selectin. First, we achieved the inhibition of the expression of sLex on the surface of HCC cells by introducing fucosyl transferase- I gene in HCC cells. In a second part of our work we used cimetidine and amiloride to inhibit the expression of E-selectin by endothelial cells. This approach resulted in inhibition of HCC cells / endothelial cells interaction and thereby tumor growth inhibition in vivo. This effect is mediated by an inhibition of tumor neoangiogenesis. This work therefore identifies genetic risk factors for HCC and allows considering another way of treatment of HCC
Wood, Alison. "N-linked protein glycosylation in Helicobacter species." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-protein-glycosylation-in-helicobacter-species(ef97ffdd-aca4-40ff-b52b-7b8ca030bc82).html.
Full textLowry, Rebecca. "Glycosylation of the Aeromonas caviae polar flagellum." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9503/.
Full textDelannoy, Philippe. "Etude des modifications de la glycosylation de la fibronectine des cellules transformées : Conséquence sur l'affinité de la fibronectine pour le collagène." Lille 1, 1989. http://www.theses.fr/1989LIL10069.
Full textLin, Chaoqi. "Synthesis and study of photoswitchable glycomacrocycles." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLN039.
Full textAs excellent photochromic molecules, azobenzene derivatives have increasing applications in the spatial and temporal photocontrol of molecular conformation, chemical reactivity, biological and pharmacological activities. In this context, an exciting attempt is introducing a photochromic motif into carbohydrate-containing macrocycles, a unique class of products with growing attention in medicinal and material science, so as to modulate their physicochemical, chemical and biologic properties by light.Two series of photoswitchable glycomacrocycles have been prepared in this thesis. The first one is obtained from 2,2’-dihydroxyazobenzene and di-O-bromoacetyl glycosides via one-pot O-alkylation approach. These macrocycles show excellent photophromic properties with high fatigue resistance. Chirality transfer from sugar to azobenzene moiety has been observed. One of the macrocycles can form organogel that responses to photo-, thermal- and mechanical stimulus. The second series of glycomacrocycles were prepared through intramolecular glycosylation by using dihydroxyazobenzene as tether. The efficiency and the stereoselective outcome of glycosylation have been investigated by modulating the nature of the linkers and the configuration of the azobenzene tether
Marchal, Ingrid. "Modification des capacités de glycosylation des cellules d'insectes." Phd thesis, Université des Sciences et Technologie de Lille - Lille I, 2001. http://tel.archives-ouvertes.fr/tel-00258437.
Full textNous nous sommes d'abord attachés à comprendre la voie de maturation des N-glycannes dans des cellules Sf9. L'utilisation d'inhibiteurs de la maturation ou du trafic intracellulaire nous a permis d'identifier des intermédiaires clés et de confirmer l'hypothèse que la maturation des N-glycannes dans les cellules d'insectes et de mammifères suivent un chemin métabolique parallèle jusqu'à la formation de l'espèce GlcNAcMan3[Fuc]GlcNAc2. Chez les insectes, cette structure est ensuite substrat d'une β-N-acétylglucosaminidase qui produit l'espèce finale Man3[Fuc]GlcNAc2.
Cette voie de maturation peut néanmoins être déviée vers la synthèse de N-glycannes de type complexe par l'addition de glycosyltransférases absentes : ainsi, l'expression d'une β1,4-galactosyltransférase permet la synthèse de l'espèce GalGlcNAcMan3[Fuc]GlcNAc2.
Notre intérêt s'est ensuite porté sur l'ingénierie de la sialylation dans les cellules d'insectes, compliquée par l'absence du donneur d'acides sialiques, le CMP-Neu5Ac. Notre stratégie a été d'exprimer la trans-sialidase de Trypanosoma cruzi sur la membrane plasmique des cellules, afin qu'elle puisse sialyler les glycoprotéines sécrétées en utilisant des donneurs du milieu. La construction exprimée grâce à un vecteur baculovirus code une enzyme active, dont une partie est retrouvée sur la membrane plasmique et sur l'enveloppe des particules virales, tandis qu'une partie, croissante avec l'infection, est soluble. Néanmoins, le système permet une sialylation quantitative d'accepteurs exogènes.
Notre étude contribue à montrer que l'ingénierie de la glycosylation dans le système baculovirus-cellules d'insectes est envisageable. Pour résoudre le problème de la sialylation, la trans-sialidase est une alternative possible aux sialyltransférases.
Alonzi, Dominic S. "Cellular Mechanism of Glycosylation Inhibition by Imino Sugars." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487138.
Full textRosenlöcher, Julia [Verfasser]. "Optimizing the glycosylation of recombinant proteins / Julia Rosenlöcher." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1112133437/34.
Full textTey, Lai-Hock. "Studies of site-selective glycosylation of dihydrofolate reductase." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55798/.
Full textHamid, Umi Marshida Abd. "Glycosylation-based approaches for potential breast cancer biomarkers." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540155.
Full textAnderson, Ross C. "Immunoassays for glycosylation of alpha-1-acid glycoprotein." Thesis, University of Sunderland, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337295.
Full textFontinopoulou, Angeliki. "Investigating the glycosylation of recombinant glycoproteins with lectins." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432779.
Full textJowett, Adrian K. "Glycosylation patterns during development of mouse molar teeth." Thesis, University of Manchester, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304035.
Full text