Relevant bibliographies by topics / Glycophagy

Academic literature on the topic 'Glycophagy'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Glycophagy"

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Mellor, Kimberley M., Upasna Varma, David I. Stapleton, and Lea M. D. Delbridge. "Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 8 (April 15, 2014): H1240—H1245. http://dx.doi.org/10.1152/ajpheart.00059.2014.

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Disturbed systemic glycemic and insulinemic status elicits cardiomyocyte metabolic stress and altered glucose handling. In diabetes, pathological myocardial glycogen accumulation occurs. Recently, evidence of a specific myocardial autophagic degradation pathway for glycogen (“glycophagy”) has been reported, differentiated from the more well-characterized protein “macrophagy” pathway. The goal of this study was to identify potential mechanisms involved in cardiac glycogen accumulation, glycophagy, and macrophagy regulation using cultured neonatal rat ventricular myocytes (NRVMs). In NRVMs, insulin-induced Akt phosphorylation was evident with 5 mM-glucose conditions (∼2.3-fold increased). Under high-glucose (30 mM) conditions, insulin-augmented phosphorylation was not observed. Accumulation of glycogen was observed in response to insulin only in high-glucose conditions (∼2-fold increase). Increased expression of the glycophagy marker starch-binding domain-containing protein-1 (STBD1, 25% increase) was observed under high-glucose and insulin conditions. Expression levels of the macrophagy markers p62 and light chain protein 3BII:I were not increased by insulin at either glucose level. Preliminary results from hearts of streptozotocin-treated diabetic rats are supportive of the findings obtained in NRVMs, suggesting diabetes induced elevated expression of STBD1 and of an additional glycophagy marker GABA(A) receptor-associated protein-like 1. Confocal microscopy demonstrated that light chain protein 3B and STBD1 immunomarkers were not colocalized in NRVMs. These findings provide the first evidence that cardiomyocyte glycophagy induction occurs under the influence of insulin and is responsive to extracellular high glucose. This study suggests that the regulation of glycogen content and glycophagy induction in the cardiomyocyte may be linked, and it is speculated that glycogen pathology in diabetic cardiomyopathy has glycophagic involvement.
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Dong, Juan, Changquan Guo, Zhaoyu Yang, Yangyang Wu, and Caiqiao Zhang. "Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens." Cells 11, no. 20 (October 18, 2022): 3270. http://dx.doi.org/10.3390/cells11203270.

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As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated. Results showed that FSH activated mitophagy and relieved mitochondrial edema in D-gal-induced senescent GCs, which was evidenced by an increased number of mitophagosomes as well as increased mitochondria-light chain 3 (LC3) colocalization. Mitophagy activation was accompanied by the activation of the AMP-activated protein kinase (AMPK) signaling pathway. Furthermore, upregulated glycophagy was demonstrated by an increased interaction of starch-binding domain protein 1 (STBD1) with GABA type A receptor-associated protein-like 1 (GABARAPL1) in D-gal-induced senescent GCs. FSH treatment further promoted glycophagy, accompanied by PI3K/AKT activation. PI3K inhibitor LY294002 and AKT inhibitor GSK690693 attenuated the effect of FSH on glycophagy and glycolysis. The inhibition of FSH-mediated autophagy attenuated the protective effect of FSH on naturally aging GC proliferation and glycolysis. The simultaneous blockage of PI3K/AKT and AMPK signaling also abolished the positive effect of FSH on naturally senescent ovarian energy regulation. These data reveal that FSH prevents chicken ovarian aging by modulating glycophagy- and mitophagy-based energy metabolism through the PI3K/AKT and AMPK pathways.
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Zhao, Hong, Mingzhu Tang, Meiqing Liu, and Linxi Chen. "Glycophagy: An emerging target in pathology." Clinica Chimica Acta 484 (September 2018): 298–303. http://dx.doi.org/10.1016/j.cca.2018.06.014.

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4

Delbridge, Lea M. D., Kimberley M. Mellor, David J. R. Taylor, and Roberta A. Gottlieb. "Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 10 (May 15, 2015): H1194—H1204. http://dx.doi.org/10.1152/ajpheart.00002.2015.

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An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly and progressing beyond a conceptualization of the autophagosome as a simple cell recycling depot. The importance of autophagy dysregulation in diabetic cardiomyopathy and in ischemic heart disease - both conditions comprising the majority of cardiac disease burden - has now become apparent. New findings have revealed that specific autophagic processes may operate in the cardiomyocyte, specialized for selective recognition and management of mitochondria and glycogen particles in addition to protein macromolecular structures. Thus mitophagy, glycophagy, and macroautophagy regulatory pathways have become the focus of intensive experimental effort, and delineating the signaling pathways involved in these processes offers potential for targeted therapeutic intervention. Chronically elevated macroautophagic activity in the diabetic myocardium is generally observed in association with structural and functional cardiomyopathy; yet there are also numerous reports of detrimental effect of autophagy suppression in diabetes. Autophagy induction has been identified as a key component of protective mechanisms that can be recruited to support the ischemic heart, but in this setting benefit may be mitigated by adverse downstream autophagic consequences. Recent report of glycophagy upregulation in diabetic cardiomyopathy opens up a novel area of investigation. Similarly, a role for glycogen management in ischemia protection through glycophagy initiation is an exciting prospect under investigation.
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Mandl, József, and Gábor Bánhegyi. "The ER – Glycogen Particle – Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy?" Pathology & Oncology Research 24, no. 4 (July 7, 2018): 821–26. http://dx.doi.org/10.1007/s12253-018-0446-0.

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Elshenawy, Dina Salem Abdelaziz, Nehal Mohammed Ramadan, Vivian Boshra Abdo, and Rehab Hamdy Ashour. "Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy." Biomedicine & Pharmacotherapy 153 (September 2022): 113382. http://dx.doi.org/10.1016/j.biopha.2022.113382.

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7

Lajoie, Jason M., and Eric V. Shusta. "Introducing glycophage arrays: Facile production, purification and patterning of glycophages." Biotechnology Journal 10, no. 1 (October 31, 2014): 20–21. http://dx.doi.org/10.1002/biot.201400591.

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8

Reichelt, M., K. Mellor, D. Stapleton, and L. Delbridge. "Glycogen Responses During Metabolic Stress are Accentuated in Female Hearts: A Role for Myocardial Glycophagy." Heart, Lung and Circulation 22 (January 2013): S63. http://dx.doi.org/10.1016/j.hlc.2013.05.150.

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Reichelt, M. E., K. M. Mellor, C. L. Curl, D. Stapleton, and L. M. D. Delbridge. "Myocardial glycophagy — A specific glycogen handling response to metabolic stress is accentuated in the female heart." Journal of Molecular and Cellular Cardiology 65 (December 2013): 67–75. http://dx.doi.org/10.1016/j.yjmcc.2013.09.014.

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10

Condello, Maria, Evelin Pellegrini, Michele Caraglia, and Stefania Meschini. "Targeting Autophagy to Overcome Human Diseases." International Journal of Molecular Sciences 20, no. 3 (February 8, 2019): 725. http://dx.doi.org/10.3390/ijms20030725.

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Autophagy is an evolutionarily conserved cellular process, through which damaged organelles and superfluous proteins are degraded, for maintaining the correct cellular balance during stress insult. It involves formation of double-membrane vesicles, named autophagosomes, that capture cytosolic cargo and deliver it to lysosomes, where the breakdown products are recycled back to cytoplasm. On the basis of degraded cell components, some selective types of autophagy can be identified (mitophagy, ribophagy, reticulophagy, lysophagy, pexophagy, lipophagy, and glycophagy). Dysregulation of autophagy can induce various disease manifestations, such as inflammation, aging, metabolic diseases, neurodegenerative disorders and cancer. The understanding of the molecular mechanism that regulates the different phases of the autophagic process and the role in the development of diseases are only in an early stage. There are still questions that must be answered concerning the functions of the autophagy-related proteins. In this review, we describe the principal cellular and molecular autophagic functions, selective types of autophagy and the main in vitro methods to detect the role of autophagy in the cellular physiology. We also summarize the importance of the autophagic behavior in some diseases to provide a novel insight for target therapies.
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Dissertations / Theses on the topic "Glycophagy"

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Balou, Gildas Rogatien. "Synthèse de glycophanes à partir du D-glucal." Thesis, Nancy 1, 2008. http://www.theses.fr/2008NAN10096/document.

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Les glycophanes sont des molécules cycliques, chirales contenant des sucres séparés par des segments hydrocarbonés. Ils sont considérés comme des hybrides de cyclophanes et de cyclodextrines. Ce travail concerne la synthèse de glycophanes symétriques à partir du D-glucal. Après la synthèse de O-glycosides insaturés et de bis-O-glycosides d’alkyle 2,3 insaturés par réarrangement de Ferrier, nous avons préparé des précurseurs bifonctionnels pour différentes réactions de macrocyclisation pour l’obtention de ces macrocycles à savoir les bis-ethers de propargyle pour la réaction de Glaser ; les azido-alcynes pour la réaction de Huisgen et les amino-acides de sucres pour le couplage peptidique. Les conditions de dilution ont permis d’obtenir des molécules-cages de symétrie C2 que nous avons déprotégées pour des essais de complexation
The aim of this work was the design and synthesis of symmetrical glycophanes from D-glucal. Glycophanes may be considered as sugar-cyclophanes hybrids. Having prepared unsaturated O-glycosides and unsaturated alkyl bis-2,3-O-glycosides by a Ferrier rearrangement, we synthetized bifunctional precursors for various reactions of macrocyclization: propargyl-ethers for the reaction of Glaser; azido-alkynes for the reaction of Huisgen and sugar amino-acids for the peptide coupling. The conditions of dilution allowed us to obtain C2 symmetric molecule-cages which were deprotected for complexation purposes
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Balou, Gildas. "Synthèse de glycophanes à partir du D-glucal." Phd thesis, Université Henri Poincaré - Nancy I, 2008. http://tel.archives-ouvertes.fr/tel-00434288.

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Les glycophanes sont des molécules cycliques, chirales contenant des sucres séparés par des segments hydrocarbonés. Ils sont considérés comme des hybrides de cyclophanes et de cyclodextrines. Ce travail concerne la synthèse de glycophanes symétriques à partir du D-glucal. Après la synthèse de O-glycosides insaturés et de bis-O-glycosides d'alkyle 2,3 insaturés par réarrangement de Ferrier, nous avons préparé des précurseurs bifonctionnels pour différentes réactions de macrocyclisation pour l'obtention de ces macrocycles à savoir les bis-ethers de propargyle pour la réaction de Glaser ; les azido-alcynes pour la réaction de Huisgen et les amino-acides de sucres pour le couplage peptidique. Les conditions de dilution ont permis d'obtenir des molécules-cages de symétrie C2 que nous avons déprotégées pour des essais de complexation.
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Book chapters on the topic "Glycophagy"

1

Ringelmann, R., and Beate Heym. "Milben-Acarus / Glycophagus." In Parasiten des Menschen, 180–81. Heidelberg: Steinkopff, 1991. http://dx.doi.org/10.1007/978-3-642-85397-5_61.

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Fujita, K., M. Mizuochi, K. Koga, and K. Ohta. "Selective One-Point Cleavage of Capped β-Cyclodextrin By Taka-Amylase A. Two-Step Synthesis of Glycophane From β-Cyclodextrin." In Proceedings of the Eighth International Symposium on Cyclodextrins, 103–6. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_22.

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