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Relevant bibliographies by topics / Glycoconjugation methods

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Journal articles
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Academic literature on the topic 'Glycoconjugation methods'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "Glycoconjugation methods"

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Park, Simon, Hsiao-Wu Hsieh, and Jacquelyn Gervay-Hague. "Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs." Molecules 23, no. 7 (2018): 1742. http://dx.doi.org/10.3390/molecules23071742.

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Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed

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Szreder, Julia, Klaudia Woźniak, Karol Erfurt, Mirosława Grymel та Gabriela Pastuch-Gawołek. "Synthesis and Preliminary Cytotoxicity Evaluation of 3-Lup-20(29)-Ene-3β,28-Diol Glycoconjugates Containing a Succinic Linker and a 1,2,3-Triazole Ring". Cancers 17, № 11 (2025): 1737. https://doi.org/10.3390/cancers17111737.

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Background: 3-Lup-20(29)-ene-3β,28-diol (betulin, BN) is a natural bioactive compound with significant synthetic and pharmacological potential. A growing body of research highlights the increasing interest in BN and its derivatives, driven by their broad biological activities (anticancer, antibacterial, anti-inflammatory, antiretroviral). However, poor bioavailability and low intracellular accumulation limit its pharmaceutical application. Methods: A promising strategy to enhance BN’s therapeutic potential is glycoconjugation. This approach improves drug bioavailability, solubility, and select

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Iorio, Anna Lisa, Elena Lenci, Chiara Marzano, et al. "HGG-05. GLUCOSE CONJUGATION FOR THE SPECIFIC TARGETING AND TREATMENT OF GLIOBLASTOMA." Neuro-Oncology 26, Supplement_4 (2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.289.

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Abstract BACKGROUND Malignant brain tumors, such as Glioblastoma (GBM), are a major challenge in oncology with a dismal prognosis. This can be in part explained by the inability to deliver more effective drugs, as Doxorubicin (DOX), into the brain because of resistance mechanisms. Malignant tumors as GBM also show an elevated glycolytic rate through glucose transporters and GLUT1 is reported to be the main mediator of BBB glucose uptake. For these reasons, we have developed an innovative approach able to increase drug efficiency and selectivity, by conjugating the anticancer agents DOX to gluc

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Iorio, A., C. Marzano, B. Tirinnanzi, et al. "P16.01.B DOXORUBICIN GLYCOSYLATION AS A NOVEL APPROACH TO SPECIFICALLY TARGET GLIOBLASTOMA." Neuro-Oncology 26, Supplement_5 (2024): v83—v84. http://dx.doi.org/10.1093/neuonc/noae144.276.

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Abstract BACKGROUND Despite recent advances in the treatment of cancer, malignant brain tumors such as Glioblastoma (GBM) are still a major challenge in oncology with a poor prognosis. This evidence can be partly explained by the inability of most drugs, such as Doxorubicin (DOX), to be delivered within the brain due to the presence of drug resistance mechanisms including the active efflux mediated by ATP-binding cassette transporters, which are overexpressed on the blood brain barrier (BBB).Malignant tumors like GBM also show a significant glycolytic rate and a high glucose request through gl

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Dziadas, Mariusz, and Henryk Jeleń. "Comparison of Dip‐it‐DART‐Orbitrap‐MS With Nitrogen Plasma to HPLC/Orbitrap‐MS in Profiling Aromatic Glycoconjugation in White Grapes." Journal of Mass Spectrometry 60, no. 5 (2025). https://doi.org/10.1002/jms.5130.

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ABSTRACTDirect analysis of aromatic glycosidic precursors in plants has posed an analytical challenge for decades. Traditional techniques, such as SPE‐GC/MS, primarily provided information on volatile aglycones released through hydrolysis. However, the application of high‐resolution mass spectrometry combined with liquid chromatography has enabled the direct analysis of intact glycosides without the need for derivatization or hydrolysis. Advances in soft ionization methods, such as DART, offer a novel approach to exploring the hidden aromatic potential in grapes without chromatographic separat

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Sarkar, Biswajit, and Narayanaswamy Jayaraman. "Glycoconjugations of Biomolecules by Chemical Methods." Frontiers in Chemistry 8 (November 4, 2020). http://dx.doi.org/10.3389/fchem.2020.570185.

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Dissertations / Theses on the topic "Glycoconjugation methods"

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Nicola, Floyd. "A novel glycoconjugation method and unexpected photo-induced site-selective protein cleavage reaction." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:aac2cbe4-76be-4238-b0ce-ce31f371cb74.

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Homogenous glycoforms of glycoproteins are one of the primary targets in glycobiology to allow for the determination of glycoprotein function and to create glycoprotein mimetics for use as therapeutic agents. Although N- and O-linked glycosylation is preferred in nature, S-linked glycoproteins are attractive synthetic targets due to their enhanced chemical stability and enzymatic resistance. This thesis reports a novel convergent method for the synthesis of S-linked glycoproteins through the site-specific ligation of 1-glycosyl thiols to olefin containing proteins. This strategy employs unnatu

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Sarkar, Biswajit. "2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5957.

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2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the glycoconjugation of amino acids, peptides and proteins. In the later part, 2,3-dideoxy sugar is used to synthesize carbohydrate macrocycle. Finally, sugar vinyl sulfoxide is used to synthesize substituted pyran via 2,6- anhydro sugar formation. Chapter 1 of the thesis is divided into two parts. The first part describes the literature on unsaturated sugar, especially 2,3-unsat

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Book chapters on the topic "Glycoconjugation methods"

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Okoth, Ronald, and Amit Basu. "Glycopolymers Prepared by Ring-Opening Metathesis Polymerization Followed by Glycoconjugation Using a Triazole-Forming “Click” Reaction." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3130-9_3.

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